{"id":10036,"date":"2025-06-02T19:05:44","date_gmt":"2025-06-02T19:05:44","guid":{"rendered":"https:\/\/csiag.eu\/?p=10036"},"modified":"2025-06-03T20:37:17","modified_gmt":"2025-06-03T20:37:17","slug":"toksisiteit-van-die-lnp-afhangende-van-die-lengte-van-die-penketting","status":"publish","type":"post","link":"https:\/\/csiag.eu\/af\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/","title":{"rendered":"Toksisiteit van LNP afhangende van die lengte van die PEG-ketting"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Inhoudsopgawe<\/p>\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/csiag.eu\/af\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Welche_LNPs_wurden_verwendet\" >Watter LNP&#039;s is gebruik?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/csiag.eu\/af\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Toxizitat_wurde_nicht_durch_Studien_uberpruft\" >Toksisiteit is nie deur studies bevestig nie<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/csiag.eu\/af\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Akkumulation_in_der_Leber\" >Akkumulasie in die lewer<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/csiag.eu\/af\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Der_Weg_in_die_Leber_und_die_Lange_der_Kette\" >Die pad na die lewer en die lengte van die ketting<\/a><\/li><\/ul><\/nav><\/div>\n<span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Leestyd<\/span> <span class=\"rt-time\"> 2<\/span> <span class=\"rt-label rt-postfix\">minute<\/span><\/span>\n<p>Hoe korter die PEG (poli\u00ebtileenglikol) ketting, hoe ho\u00ebr die toksisiteit van die LNP. BioNTech verduidelik dit in sy <a href=\"https:\/\/www.mdpi.com\/2227-9059\/9\/5\/530\" target=\"_blank\" rel=\"noreferrer noopener\">publikasie<\/a> \u201cNie-immunoterapie-toepassing van LNP-mRNA: Maksimalisering van doeltreffendheid en veiligheid\u201d vanaf 10 Mei 2021, hoewel effens anders bewoord: \u201cMaksimalisering van doeltreffendheid.\u201d<br>Die toksisiteit is gebaseer op die feit dat al drie die ioniseerbare kationiese lipiede nie bioafbreekbaar is nie en hul onvermydelike ophoping in die liggaam sitotoksiese gevolge het.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Welche_LNPs_wurden_verwendet\"><\/span>Watter LNP&#039;s is gebruik?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><em>Pfizer<\/em> \/ <em>BioNTech<\/em> \u2013 BNT162b2 \u2013 <a href=\"https:\/\/www.echelon-inc.com\/product\/alc-0315\/\" target=\"_blank\" rel=\"noreferrer noopener\">ALC-0315<\/a> (ioniseerbaar) en <a href=\"https:\/\/www.echelon-inc.com\/product\/alc-0159\/\" target=\"_blank\" rel=\"noreferrer noopener\">ALC-0159<\/a> (Gepegileer)<br><em>Moderne<\/em> \u2013 <a href=\"https:\/\/www.echelon-inc.com\/product\/sm-102\/\" target=\"_blank\" rel=\"noreferrer noopener\">SM-102<\/a> (ioniseerbaar) en <a href=\"https:\/\/www.echelon-inc.com\/product\/dmg-peg-2000\/\" target=\"_blank\" rel=\"noreferrer noopener\">PEG2000-DMG<\/a> (Gepegileer)<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"562\" src=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-1024x562.png\" alt=\"\" class=\"wp-image-10045\" srcset=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-1024x562.png 1024w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-300x165.png 300w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-768x421.png 768w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-18x10.png 18w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image.png 1456w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<p>Vir al die bogenoemde lipiede, die vervaardiger (bv. <a href=\"https:\/\/www.echelon-inc.com\/product\/alc-0315\/#tab-description\" target=\"_blank\" rel=\"noreferrer noopener\">Echelon Biosciences<\/a>) \u201c\u2026Hierdie is &#039;n reagensgraadproduk, slegs vir navorsingsgebruik.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Toxizitat_wurde_nicht_durch_Studien_uberpruft\"><\/span>Toksisiteit is nie deur studies bevestig nie<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Volgens die <a href=\"https:\/\/www.tga.gov.au\/sites\/default\/files\/foi-2389-06.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">publikasie<\/a> \u201cDie nie-kliniese evalueringsverslag BNT 162b2 mRNA COVID-19-entstof COMIRNATY\u2122\u201d van die Australiese regering \u2013 Departement van Gesondheid vanaf Januarie 2021 kan op bladsy 11 gelees word: \u201cDie toksisiteit van LNP-formulering of die nuwe hulpstowwe alleen is nie spesifiek bestudeer nie.\u201d<br>Met ander woorde, geen toksisiteitstudies is uitgevoer rakende die gebruik en effekte van die bogenoemde nuwe LNP-hulpstowwe nie.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Akkumulation_in_der_Leber\"><\/span>Akkumulasie in die lewer<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Baie geneesmiddels word gedeeltelik of volledig deur die lewer gemetaboliseer en beland in die bloedstroom. Die bogenoemde hulpstof ALC-315 versamel ook in die lewer, soos getoon deur die <a href=\"https:\/\/www.judicialwatch.org\/wp-content\/uploads\/2022\/03\/JW-v-HHS-prod-3-02418.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Gedeeltelike reaksie op navraag nr. 2021-4379<\/a> kragtens die Wet op Vryheid van Inligting (FOIA), wat die onderwerp is van die klagte in Judicial Watch, Inc. v. U.S. Department of Health and Human Services (21-cv-2418), tans hangende in die Amerikaanse Distrikshof vir die Distrik van Columbia, op bladsy 16 van 466:<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"542\" src=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-1024x542.png\" alt=\"\" class=\"wp-image-10054\" srcset=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-1024x542.png 1024w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-300x159.png 300w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-768x407.png 768w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-18x10.png 18w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3.png 1212w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>Ook genoem op bladsy 45 hierbo <a href=\"https:\/\/www.tga.gov.au\/sites\/default\/files\/foi-2389-06.pdf\" target=\"_blank\" rel=\"noopener\">Verslae<\/a>:<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"55\" src=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-1024x55.png\" alt=\"\" class=\"wp-image-10060\" srcset=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-1024x55.png 1024w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-300x16.png 300w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-768x42.png 768w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-18x1.png 18w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4.png 1218w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>Op bladsy 46 word die suiwer teoreties veronderstelde metaboliese pad uiteengesit gebaseer op in vitro-eksperimente, wat egter nie in mense geverifieer is nie.<\/p>\n\n\n\n<p>Terwyl <a href=\"https:\/\/www.statnews.com\/2017\/01\/10\/moderna-trouble-mrna\/\" target=\"_blank\" rel=\"noreferrer noopener\">Moderne<\/a> geskei van ALC-0315 weens lewerintoleransie en het die SM-platform self ontwikkel (ALC-0315 het bewys dat dit te toksies is vir geenterapie van die lewersiekte Crigler-Najjar-sindroom, so die destydse navorsingsvennoot <em>Alexion<\/em> (het die studie om veiligheidsredes gestaak), gebruik BioNTech \/ Pfizer dit steeds ten spyte daarvan dat hulle beter weet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Der_Weg_in_die_Leber_und_die_Lange_der_Kette\"><\/span>Die pad na die lewer en die lengte van die ketting<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><\/p>\n\n\n\n<p>\u2026 word vervolg \u2026<\/p>","protected":false},"excerpt":{"rendered":"<p><span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Leestyd<\/span> <span class=\"rt-time\"> 2<\/span> <span class=\"rt-label rt-postfix\">minute<\/span><\/span>Je k\u00fcrzer die PEG-Kette (Polyethylenglycol), desto h\u00f6her die Toxizit\u00e4t der LNP. Dies erkl\u00e4rt BioNTech in seiner Ver\u00f6ffentlichung &#8222;Non-Immunotherapy Application of LNP-mRNA: Maximizing Efficacy and Safety&#8220; vom 10.05.2021, wenn auch &#8211; etwas &#8211; anders formuliert: &#8222;Maximizing Efficacy&#8220;.Die Toxizit\u00e4t beruht auf der Tatsache, dass alle drei der ionisierbaren kationischen Lipide nicht biologisch abbaubar sind und ihre, damit&hellip;&nbsp;<a href=\"https:\/\/csiag.eu\/af\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/\" rel=\"bookmark\">Lees Meer \u00bb<span class=\"screen-reader-text\">Toksisiteit van LNP afhangende van die lengte van die PEG-ketting<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[628,316,1078],"tags":[5067,5066,5074,22,36,5080,5079,5069,5075,5071,4812,105,5073,5077,5070,5072,23,5076,5078,44],"class_list":["post-10036","post","type-post","status-publish","format-standard","hentry","category-corona","category-corona-blog","category-medizin","tag-alc-159","tag-alc-315","tag-alnylam","tag-biontech","tag-bnt162b2","tag-cholesterol","tag-dlin-mc3-dma","tag-dmg-peg2000","tag-elasomeran","tag-ionisierbar","tag-lnp","tag-moderna","tag-patisiran","tag-peg-lipid","tag-peg2000-dmg","tag-pegyliert","tag-pfizer","tag-phosholipid","tag-sterol","tag-tozinameran"],"modified_by":"Achim Goerner","_links":{"self":[{"href":"https:\/\/csiag.eu\/af\/wp-json\/wp\/v2\/posts\/10036","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csiag.eu\/af\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csiag.eu\/af\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csiag.eu\/af\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csiag.eu\/af\/wp-json\/wp\/v2\/comments?post=10036"}],"version-history":[{"count":0,"href":"https:\/\/csiag.eu\/af\/wp-json\/wp\/v2\/posts\/10036\/revisions"}],"wp:attachment":[{"href":"https:\/\/csiag.eu\/af\/wp-json\/wp\/v2\/media?parent=10036"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csiag.eu\/af\/wp-json\/wp\/v2\/categories?post=10036"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csiag.eu\/af\/wp-json\/wp\/v2\/tags?post=10036"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}