{"id":10036,"date":"2025-06-02T19:05:44","date_gmt":"2025-06-02T19:05:44","guid":{"rendered":"https:\/\/csiag.eu\/?p=10036"},"modified":"2025-06-03T20:37:17","modified_gmt":"2025-06-03T20:37:17","slug":"toxicita-lnp-v-zavislosti-na-delce-retizku-kolicku","status":"publish","type":"post","link":"https:\/\/csiag.eu\/cs\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/","title":{"rendered":"Toxicita LNP v z\u00e1vislosti na d\u00e9lce \u0159et\u011bzce PEG"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_83 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Obsah<\/p>\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/csiag.eu\/cs\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Welche_LNPs_wurden_verwendet\" >Kter\u00e9 LNP byly pou\u017eity?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/csiag.eu\/cs\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Toxizitat_wurde_nicht_durch_Studien_uberpruft\" >Toxicita nebyla studiemi ov\u011b\u0159ena.<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/csiag.eu\/cs\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Akkumulation_in_der_Leber\" >Hromad\u011bn\u00ed v j\u00e1trech<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/csiag.eu\/cs\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Der_Weg_in_die_Leber_und_die_Lange_der_Kette\" >Cesta do jater a d\u00e9lka \u0159et\u011bzce<\/a><\/li><\/ul><\/nav><\/div>\n<span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Doba \u010dten\u00ed<\/span> <span class=\"rt-time\"> 2<\/span> <span class=\"rt-label rt-postfix\">minuty<\/span><\/span>\n<p>\u010c\u00edm krat\u0161\u00ed je \u0159et\u011bzec PEG (polyethylenglykol), t\u00edm vy\u0161\u0161\u00ed je toxicita LNP. Spole\u010dnost BioNTech to vysv\u011btluje ve sv\u00e9m <a href=\"https:\/\/www.mdpi.com\/2227-9059\/9\/5\/530\" target=\"_blank\" rel=\"noreferrer noopener\">Publikace<\/a> \"Non-Immunotherapy Application of LNP-mRNA: Maximising Efficacy and Safety\" z 10.05.2021, i kdy\u017e pon\u011bkud jinak formulovan\u00fd: \"Maximising Efficacy\".<br>Toxicita je zalo\u017eena na skute\u010dnosti, \u017ee v\u0161echny t\u0159i ionizovateln\u00e9 kationtov\u00e9 lipidy nejsou biologicky odbourateln\u00e9 a jejich nevyhnuteln\u00e1 akumulace v t\u011ble m\u00e1 cytotoxick\u00e9 d\u016fsledky.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Welche_LNPs_wurden_verwendet\"><\/span>Kter\u00e9 LNP byly pou\u017eity?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><em>Pfizer<\/em> \/ <em>BioNTech<\/em> - BNT162b2 - <a href=\"https:\/\/www.echelon-inc.com\/product\/alc-0315\/\" target=\"_blank\" rel=\"noreferrer noopener\">ALC-0315<\/a> (ionizovateln\u00e9) a <a href=\"https:\/\/www.echelon-inc.com\/product\/alc-0159\/\" target=\"_blank\" rel=\"noreferrer noopener\">ALC-0159<\/a> (PEGylovan\u00fd)<br><em>Moderna<\/em> - <a href=\"https:\/\/www.echelon-inc.com\/product\/sm-102\/\" target=\"_blank\" rel=\"noreferrer noopener\">SM-102<\/a> (ionizovateln\u00e9) a <a href=\"https:\/\/www.echelon-inc.com\/product\/dmg-peg-2000\/\" target=\"_blank\" rel=\"noreferrer noopener\">PEG2000-DMG<\/a> (PEGylovan\u00fd)<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"562\" src=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-1024x562.png\" alt=\"\" class=\"wp-image-10045\" srcset=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-1024x562.png 1024w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-300x165.png 300w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-768x421.png 768w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-18x10.png 18w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image.png 1456w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<p>U v\u0161ech v\u00fd\u0161e uveden\u00fdch lipid\u016f v\u00fdrobci (nap\u0159. <a href=\"https:\/\/www.echelon-inc.com\/product\/alc-0315\/#tab-description\" target=\"_blank\" rel=\"noreferrer noopener\">Echelon Biosciences<\/a>) \"... Jedn\u00e1 se o v\u00fdrobek v kvalit\u011b \u010dinidla, pouze pro v\u00fdzkumn\u00e9 \u00fa\u010dely.\"<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Toxizitat_wurde_nicht_durch_Studien_uberpruft\"><\/span>Toxicita nebyla studiemi ov\u011b\u0159ena.<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Podle <a href=\"https:\/\/www.tga.gov.au\/sites\/default\/files\/foi-2389-06.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Publikace<\/a> \"Nonclinical Evaluation Report BNT 162b2 mRNA COVID-19 vaccine COMIRNATY\u2122\" australsk\u00e9 vl\u00e1dy - ministerstva zdravotnictv\u00ed z ledna 2021 si m\u016f\u017eete p\u0159e\u010d\u00edst na stran\u011b 11: \"Toxicita samotn\u00e9ho p\u0159\u00edpravku LNP nebo nov\u00fdch pomocn\u00fdch l\u00e1tek nebyla specificky studov\u00e1na.\"<br>Jin\u00fdmi slovy, nebyly provedeny \u017e\u00e1dn\u00e9 studie toxicity t\u00fdkaj\u00edc\u00ed se pou\u017eit\u00ed a \u00fa\u010dink\u016f v\u00fd\u0161e uveden\u00fdch nov\u00fdch pomocn\u00fdch l\u00e1tek LNP.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Akkumulation_in_der_Leber\"><\/span>Hromad\u011bn\u00ed v j\u00e1trech<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Mnoho l\u00e9k\u016f je \u010d\u00e1ste\u010dn\u011b nebo zcela metabolizov\u00e1no j\u00e1try a dost\u00e1v\u00e1 se do krevn\u00edho ob\u011bhu. V\u00fd\u0161e zm\u00edn\u011bn\u00e1 pomocn\u00e1 l\u00e1tka ALC-315 se tak\u00e9 kumuluje v j\u00e1trech, jak je patrn\u00e9 z obr\u00e1zku <a href=\"https:\/\/www.judicialwatch.org\/wp-content\/uploads\/2022\/03\/JW-v-HHS-prod-3-02418.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">\u010c\u00e1ste\u010dn\u00e1 odpov\u011b\u010f na ot\u00e1zku \u010d. 2021-4379<\/a> podle z\u00e1kona o svobodn\u00e9m p\u0159\u00edstupu k informac\u00edm (Freedom of Information Act - FOIA), kter\u00fd je p\u0159edm\u011btem st\u00ed\u017enosti ve v\u011bci Judicial Watch, Inc. v. U.S. Department of Health and Human Services (21-cv-2418), kter\u00e1 je v sou\u010dasn\u00e9 dob\u011b projedn\u00e1v\u00e1na u okresn\u00edho soudu USA pro okres Columbia, na stran\u011b 16 z 466:<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"542\" src=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-1024x542.png\" alt=\"\" class=\"wp-image-10054\" srcset=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-1024x542.png 1024w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-300x159.png 300w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-768x407.png 768w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-18x10.png 18w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3.png 1212w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>Uvedeno tak\u00e9 na stran\u011b 45 v\u00fd\u0161e uveden\u00e9 zpr\u00e1vy. <a href=\"https:\/\/www.tga.gov.au\/sites\/default\/files\/foi-2389-06.pdf\" target=\"_blank\" rel=\"noopener\">Zpr\u00e1vy<\/a>:<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"55\" src=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-1024x55.png\" alt=\"\" class=\"wp-image-10060\" srcset=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-1024x55.png 1024w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-300x16.png 300w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-768x42.png 768w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-18x1.png 18w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4.png 1218w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>Na stran\u011b 46 je pops\u00e1na \u010dist\u011b teoreticky p\u0159edpokl\u00e1dan\u00e1 metabolick\u00e1 cesta na z\u00e1klad\u011b experiment\u016f in vitro, kter\u00e1 v\u0161ak nebyla ov\u011b\u0159ena u lid\u00ed.<\/p>\n\n\n\n<p>Zat\u00edmco <a href=\"https:\/\/www.statnews.com\/2017\/01\/10\/moderna-trouble-mrna\/\" target=\"_blank\" rel=\"noreferrer noopener\">Moderna<\/a> ukon\u010dila v\u00fdrobu p\u0159\u00edpravku ALC-0315 z d\u016fvodu neslu\u010ditelnosti s j\u00e1try a vyvinula vlastn\u00ed platformu SM (p\u0159\u00edpravek ALC-0315 se uk\u00e1zal jako p\u0159\u00edli\u0161 toxick\u00fd pro genovou terapii jatern\u00edho onemocn\u011bn\u00ed Crigler-Najjar\u016fv syndrom, tak\u017ee tehdej\u0161\u00ed partner ve v\u00fdzkumu <em>Alexion<\/em> zastavila studii z bezpe\u010dnostn\u00edch d\u016fvod\u016f), spole\u010dnost BioNTech \/ Pfizer je proti sv\u00e9mu nejlep\u0161\u00edmu uv\u00e1\u017een\u00ed nad\u00e1le pou\u017e\u00edv\u00e1.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Der_Weg_in_die_Leber_und_die_Lange_der_Kette\"><\/span>Cesta do jater a d\u00e9lka \u0159et\u011bzce<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><\/p>\n\n\n\n<p>... bude pokra\u010dovat...<\/p>","protected":false},"excerpt":{"rendered":"<p><span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Doba \u010dten\u00ed<\/span> <span class=\"rt-time\"> 2<\/span> <span class=\"rt-label rt-postfix\">minuty<\/span><\/span>\u010c\u00edm krat\u0161\u00ed je \u0159et\u011bzec PEG (polyethylenglykol), t\u00edm vy\u0161\u0161\u00ed je toxicita LNP. Spole\u010dnost BioNTech to vysv\u011btluje ve sv\u00e9 publikaci \"Non-Immunotherapy Application of LNP-mRNA: Maximising Efficacy and Safety\" z 10.5.2021, i kdy\u017e formulovan\u00e9 - pon\u011bkud - jinak: \"Maximising Efficacy\". toxicita vych\u00e1z\u00ed ze skute\u010dnosti, \u017ee v\u0161echny t\u0159i ionizovateln\u00e9 kationtov\u00e9 lipidy jsou biologicky nerozlo\u017eiteln\u00e9, a jejich toxicita je tedy...&nbsp;<a href=\"https:\/\/csiag.eu\/cs\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/\" rel=\"bookmark\">\u010c\u00edst d\u00e1le \"<span class=\"screen-reader-text\">Toxicita LNP v z\u00e1vislosti na d\u00e9lce \u0159et\u011bzce PEG<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[628,316,1078],"tags":[5067,5066,5074,22,36,5080,5079,5069,5075,5071,4812,105,5073,5077,5070,5072,23,5076,5078,44],"class_list":["post-10036","post","type-post","status-publish","format-standard","hentry","category-corona","category-corona-blog","category-medizin","tag-alc-159","tag-alc-315","tag-alnylam","tag-biontech","tag-bnt162b2","tag-cholesterol","tag-dlin-mc3-dma","tag-dmg-peg2000","tag-elasomeran","tag-ionisierbar","tag-lnp","tag-moderna","tag-patisiran","tag-peg-lipid","tag-peg2000-dmg","tag-pegyliert","tag-pfizer","tag-phosholipid","tag-sterol","tag-tozinameran"],"modified_by":"Achim Goerner","_links":{"self":[{"href":"https:\/\/csiag.eu\/cs\/wp-json\/wp\/v2\/posts\/10036","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csiag.eu\/cs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csiag.eu\/cs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csiag.eu\/cs\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csiag.eu\/cs\/wp-json\/wp\/v2\/comments?post=10036"}],"version-history":[{"count":0,"href":"https:\/\/csiag.eu\/cs\/wp-json\/wp\/v2\/posts\/10036\/revisions"}],"wp:attachment":[{"href":"https:\/\/csiag.eu\/cs\/wp-json\/wp\/v2\/media?parent=10036"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csiag.eu\/cs\/wp-json\/wp\/v2\/categories?post=10036"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csiag.eu\/cs\/wp-json\/wp\/v2\/tags?post=10036"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}