{"id":12784,"date":"2026-02-18T13:51:00","date_gmt":"2026-02-18T13:51:00","guid":{"rendered":"https:\/\/csiag.eu\/?p=12784"},"modified":"2026-02-18T14:26:28","modified_gmt":"2026-02-18T14:26:28","slug":"fotobiomodulace-pbm","status":"publish","type":"post","link":"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/","title":{"rendered":"Fotobiomodulace (PBM)"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Obsah<\/p>\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Einleitung\" >\u00davod<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Indikationen_auf_einen_Blick\" >P\u0159ehled indikac\u00ed<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Haut_Wundheilung_Kollagen_660_nm\" >K\u016f\u017ee, hojen\u00ed ran a kolagen (660 nm)<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Ubergreifende_Reviews_Mechanismen\" >Komplexn\u00ed recenze a mechanismy<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Kollagensynthese_Hautverjungung\" >Synt\u00e9za kolagenu a omlazen\u00ed pleti<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Klinische_Studien_Wundheilung_JAAD\" >Klinick\u00e9 studie Hojen\u00ed ran (JAAD)<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Muskeln_Sport_Rehabilitation_850_nm\" >Svaly, sport a rehabilitace (850 nm)<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Skelettmuskelregeneration\" >Regenerace kostern\u00edho svalstva<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Meta-Analysen_Sportleistung_Muskelkater\" >Metaanal\u00fdzy sportovn\u00edho v\u00fdkonu a svalov\u00e9 bolestivosti<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Gehirn_Kognition_Neurologie_810%E2%80%931064_nm\" >Mozek, kognice a neurologie (810-1 064 nm)<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Mechanismen_allgemeine_Wirkungen\" >Mechanismy a obecn\u00e9 \u00fa\u010dinky<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Alzheimer_Demenz\" >Alzheimerova choroba a demence<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#TBI_Entgiftung_1064_nm\" >TBI a detoxikace (1 064 nm)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Schmerzmanagement\" >L\u00e9\u010dba bolesti<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Ubergreifende_Reviews\" >Komplexn\u00ed recenze<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Fibromyalgie\" >Fibromyalgie<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Kniearthrose_Tendinopathie\" >Osteoartr\u00f3za kolene a tendinopatie<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Neuropathischer_Schmerz\" >Neuropatick\u00e1 bolest<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Augenheilkunde_AMD\" >Oftalmologie (AMD)<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Altersbedingte_Makuladegeneration\" >V\u011bkem podm\u00edn\u011bn\u00e1 makul\u00e1rn\u00ed degenerace<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Onkologie_Mukositis\" >Onkologie a mukozitida<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Leitlinien\" >Pokyny<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Chemotherapie-induzierte_Mukositis\" >Chemoterapi\u00ed vyvolan\u00e1 mukozitida<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Kopf-Hals-Karzinome_Strahlentherapie\" >Rakovina hlavy a krku a radioterapie<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Immunsystem_Entzundung\" >Imunitn\u00ed syst\u00e9m a z\u00e1n\u011bt<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-26\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Immunmodulation\" >Imunomodulace<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-27\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Klinische_Empfehlungen\" >Klinick\u00e1 doporu\u010den\u00ed<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-28\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Allgemeine_Dosierungsregeln_Konsensus\" >Obecn\u00e1 pravidla d\u00e1vkov\u00e1n\u00ed (konsenzus)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-29\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Evidenzstarke_nach_Bereich\" >S\u00edla d\u016fkaz\u016f podle oblast\u00ed<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-30\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Kontakt_zu_PBM-Anwendern_%E2%80%93_Arzte_Kliniken\" >Kontakt s u\u017eivateli PBM - l\u00e9ka\u0159i \/ kliniky<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-31\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Augenheilkunde_%E2%80%93_Trockene_AMD_Makuladegeneration\" >Oftalmologie - Such\u00e1 AMD (makul\u00e1rn\u00ed degenerace)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-32\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Onkologie_%E2%80%93_Orale_Mukositis_Chemo-Strahlentherapiefolge\" >Onkologie - Z\u00e1n\u011bt \u00fastn\u00ed sliznice (n\u00e1sledek chemoterapie\/radioterapie)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-33\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Dermatologie_%E2%80%93_Haut_Wundheilung_Akne_Psoriasis\" >Dermatologie - k\u016f\u017ee, hojen\u00ed ran, akn\u00e9, lup\u00e9nka<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-34\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Zahnmedizin_MKG-Chirurgie\" >Stomatologie \/ \u010delistn\u00ed chirurgie<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-35\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Neurologie_Psychiatrie_%E2%80%93_Alzheimer_TBI_Depression_fruhe_Phase\" >Neurologie\/psychiatrie - Alzheimerova choroba, TBI, deprese (ran\u00e1 f\u00e1ze)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-36\" href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/#Allgemeine_Suchwerkzeuge\" >Obecn\u00e9 vyhled\u00e1vac\u00ed n\u00e1stroje<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Doba \u010dten\u00ed<\/span> <span class=\"rt-time\"> 12<\/span> <span class=\"rt-label rt-postfix\">minuty<\/span><\/span>\n<p>Komplexn\u00ed p\u0159ehled studi\u00ed 2023-2025<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Einleitung\"><\/span>\u00davod<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Fotobiomodulace (PBM), zn\u00e1m\u00e1 tak\u00e9 jako n\u00edzko\u00farov\u0148ov\u00e1 laserov\u00e1 terapie (LLLT), je neinvazivn\u00ed terapeutick\u00e1 metoda, kter\u00e1 vyu\u017e\u00edv\u00e1 sv\u011btlo specifick\u00fdch vlnov\u00fdch d\u00e9lek ke stimulaci biologick\u00fdch proces\u016f v \u017eiv\u00e9 tk\u00e1ni.<br>Hlavn\u00edm mechanismem je absorpce foton\u016f mitochondri\u00e1ln\u00edm fotoakceptorem. <em>Cytochrom c oxid\u00e1za<\/em> (CCO), co\u017e je <em>Synt\u00e9za ATP<\/em> moduluje reaktivn\u00ed formy kysl\u00edku a spou\u0161t\u00ed kask\u00e1du proces\u016f bun\u011b\u010dn\u00e9 regenerace.<\/p>\n\n\n\n<p>Terapeuticky relevantn\u00ed \u201eoptick\u00e9 okno\u201c je v rozmez\u00ed 600 a\u017e 1100 nm. T\u0159i klinicky zvl\u00e1\u0161t\u011b d\u016fle\u017eit\u00e9 vlnov\u00e9 d\u00e9lky jsou:<\/p>\n\n\n\n<p><strong>660 nm<\/strong><br>Hloubka pr\u016fniku 1-10 mm, hustota v\u00fdkonu 6-50 mW\/cm\u00b2<br>Ide\u00e1ln\u00ed pro poko\u017eku, hojen\u00ed ran a povrchov\u00e9 tk\u00e1n\u011b.<\/p>\n\n\n\n<p><strong>850 nm<\/strong><br>Hloubka pr\u016fniku a\u017e 50 mm, hustota v\u00fdkonu 50-100 mW\/cm\u00b2<br>Vhodn\u00e9 pro svaly, klouby a hlub\u0161\u00ed struktury.<\/p>\n\n\n\n<p><strong>1 050-1 064 nm<\/strong><br>Hlubok\u00fd pr\u016fnik do tk\u00e1n\u011b, hustota v\u00fdkonu 25-285 mW\/cm\u00b2 (transkrani\u00e1ln\u011b)<br>Relevantn\u00ed pro neurologii, mozkovou a oftalmologii.<\/p>\n\n\n\n<p>Z\u00e1kladn\u00ed princip stanoven\u00ed d\u00e1vky se \u0159\u00edd\u00ed <em>Arndt-Schulzova k\u0159ivka<\/em> (Hormesis):<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>P\u0159\u00edli\u0161 m\u00e1lo sv\u011btla nem\u00e1 \u017e\u00e1dn\u00fd \u00fa\u010dinek, optim\u00e1ln\u00ed d\u00e1vka stimuluje<\/li>\n\n\n\n<li>P\u0159\u00edli\u0161 velk\u00e9 mno\u017estv\u00ed m\u00e1 inhibi\u010dn\u00ed a\u017e po\u0161kozuj\u00edc\u00ed \u00fa\u010dinek na bu\u0148ky.<\/li>\n<\/ul>\n\n\n\n<p>Tento dvouf\u00e1zov\u00fd vztah vysv\u011btluje, pro\u010d je pro \u00fasp\u011b\u0161nou terapii z\u00e1sadn\u00ed spr\u00e1vn\u00e1 hustota v\u00fdkonu a energie.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Indikationen_auf_einen_Blick\"><\/span>P\u0159ehled indikac\u00ed<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>N\u00e1sleduj\u00edc\u00ed tabulka shrnuje parametry pou\u017eit\u00e9 v klinick\u00fdch studi\u00edch (vlnov\u00e1 d\u00e9lka, hustota v\u00fdkonu, hustota energie, doba trv\u00e1n\u00ed, frekvence) pro jednotliv\u00e9 oblasti l\u00e9\u010dby. <br>Zdroje: Hamblin\/Harvard (<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8355782\/\" target=\"_blank\" rel=\"noreferrer noopener\">PMC8355782<\/a>), <a href=\"https:\/\/waltpbm.org\/\" target=\"_blank\" rel=\"noopener\">Pokyny WALT<\/a>, klinick\u00e1 hodnocen\u00ed 2020-2025.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><td><strong>Indikace<\/strong><\/td><td><strong>Vlnov\u00e1 d\u00e9lka<\/strong><\/td><td><strong>Hustota v\u00fdkonu<\/strong><\/td><td><strong>Hustota energie<\/strong><\/td><td><strong>Doba trv\u00e1n\u00ed \/ sezen\u00ed<\/strong><\/td><td><strong>Frekvence<\/strong><\/td><\/tr><\/thead><tbody><tr><td>K\u016f\u017ee \/ Kolagen<\/td><td>660 nm<\/td><td>6-50 mW\/cm\u00b2<\/td><td>8-16 J\/cm\u00b2<\/td><td>10-21 min<\/td><td>2-3\u00d7 t\u00fddn\u011b<\/td><\/tr><tr><td>Hojen\u00ed ran<\/td><td>630-660 nm<\/td><td>10-50 mW\/cm\u00b2<\/td><td>4-15 J\/cm\u00b2<\/td><td>7-20 min<\/td><td>denn\u011b - 3\u00d7 t\u00fddn\u011b<\/td><\/tr><tr><td>Regenerace sval\u016f<\/td><td>808-850 nm<\/td><td>50-100 mW\/cm\u00b2<\/td><td>10-30 J\/cm\u00b2<\/td><td>5-15 min<\/td><td>p\u0159\u00edmo p\u0159ed\/po sportu<\/td><\/tr><tr><td>Chronick\u00e1 bolest<\/td><td>630-905 nm<\/td><td>40-100 mW\/cm\u00b2<\/td><td>4-10 J\/cm\u00b2<\/td><td>10-20 min<\/td><td>3\u00d7 t\u00fddn\u011b, 6-12 t\u00fddn\u016f.<\/td><\/tr><tr><td>Fibromyalgie<\/td><td>630-1 100 nm (cel\u00e9 t\u011blo)<\/td><td>prom\u011bnn\u00e1<\/td><td>1-150 J\/cm\u00b2<\/td><td>15-30 min<\/td><td>2-3\u00d7 t\u00fddn\u011b, 4-6 t\u00fddn\u016f.<\/td><\/tr><tr><td>Osteoartr\u00f3za kolene<\/td><td>630-850 nm<\/td><td>40-80 mW\/cm\u00b2<\/td><td>4-10 J\/cm\u00b2<\/td><td>10-20 min<\/td><td>3\u00d7 t\u00fddn\u011b<\/td><\/tr><tr><td>Mozek \/ Pozn\u00e1v\u00e1n\u00ed<\/td><td>810-1 064 nm (transkrani\u00e1ln\u011b)<\/td><td>25-285 mW\/cm\u00b2<\/td><td>20-60 J\/cm\u00b2<\/td><td>10-20 min<\/td><td>3\u00d7 t\u00fddn\u011b<\/td><\/tr><tr><td>AMD \/ Oko<\/td><td>590 + 660 + 850 nm<\/td><td>0,3-15 \u03bcW\/cm\u00b2 (s\u00edtnice)<\/td><td>Velmi n\u00edzk\u00e1<\/td><td>3-10 min \/ sezen\u00ed<\/td><td>3\u00d7 t\u00fddn\u011b a\u017e denn\u011b<\/td><\/tr><tr><td>Mukozitida (onkologie)<\/td><td>630-660 nm<\/td><td>10-25 mW\/cm\u00b2<\/td><td>2-6 J\/cm\u00b2<\/td><td>3-5 min \/ bod<\/td><td>denn\u011b b\u011bhem l\u00e9\u010dby<\/td><\/tr><tr><td>Imunomodulace \/ z\u00e1n\u011bt<\/td><td>650-950 nm<\/td><td>prom\u011bnn\u00e1<\/td><td>1-10 J\/cm\u00b2<\/td><td>5-15 min<\/td><td>3\u00d7 t\u00fddn\u011b<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><em>Hustota v\u00fdkonu = intenzita z\u00e1\u0159en\u00ed (mW\/cm\u00b2) na povrchu tk\u00e1n\u011b.<\/em><br><em>Hustota energie = fluence (J\/cm\u00b2) na relaci.<\/em><br><em>AMD: Hodnoty oz\u00e1\u0159en\u00ed s\u00edtnice jsou v\u00fdrazn\u011b ni\u017e\u0161\u00ed ne\u017e hodnoty na povrchu k\u016f\u017ee.<\/em><br><em><strong>N\u00e1pov\u011bda<\/strong>Neexistuje jednotn\u00fd mezin\u00e1rodn\u00ed standard - hodnoty odr\u00e1\u017eej\u00ed konsenzus z metaanal\u00fdz a doporu\u010den\u00ed WALT.<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Haut_Wundheilung_Kollagen_660_nm\"><\/span>K\u016f\u017ee, hojen\u00ed ran a kolagen (660 nm)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u010cerven\u00e9 sv\u011btlo o vlnov\u00e9 d\u00e9lce 660 nm je zvl\u00e1\u0161t\u011b \u00fa\u010dinn\u011b absorbov\u00e1no ko\u017en\u00edmi chromofory a aktivuje synt\u00e9zu kolagenu ve fibroblastech prost\u0159ednictv\u00edm zv\u00fd\u0161en\u00e9 exprese gen\u016f COL1A1 a COL3A1 a uvol\u0148ov\u00e1n\u00ed MMP-9 a NO. Hloubka pr\u016fniku: 1-10 mm (epidermis, dermis, hypodermis). Dvouf\u00e1zov\u00fd pr\u016fb\u011bh d\u00e1vky je zvl\u00e1\u0161t\u011b v\u00fdrazn\u00fd v ko\u017en\u00ed tk\u00e1ni: hustota energie nad 20 J\/cm\u00b2 m\u016f\u017ee vyvolat oxida\u010dn\u00ed stres a zp\u011btnou stimulaci kolagenu.<\/p>\n\n\n\n<p><strong>Parametry<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Vlnov\u00e1 d\u00e9lka 660 nm (tak\u00e9 630-680 nm)<\/li>\n\n\n\n<li>Hustota v\u00fdkonu 6-50 mW\/cm\u00b2 (LED: 6-30; laser: 30-50)<\/li>\n\n\n\n<li>Hustota energie 8-16 J\/cm\u00b2 (optim\u00e1ln\u00ed)<\/li>\n\n\n\n<li>Doba trv\u00e1n\u00ed 10-21 min | 3\u00d7 t\u00fddn\u011b<\/li>\n\n\n\n<li>Nejm\u00e9n\u011b 8 t\u00fddn\u016f pro omlazen\u00ed poko\u017eky; 4 t\u00fddny pro hojen\u00ed ran.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Ubergreifende_Reviews_Mechanismen\"><\/span>Komplexn\u00ed recenze a mechanismy<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>Od sv\u011btla k l\u00e9\u010den\u00ed: fotobiomodula\u010dn\u00ed terapie v l\u00e9ka\u0159sk\u00fdch oborech<\/strong><br><em>Journal of Translational Medicine (2025)<\/em><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12751248\/\" target=\"_blank\" rel=\"noopener\"> Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>Komplexn\u00ed p\u0159ehled kombinuj\u00edc\u00ed fotofyziku, mitochondri\u00e1ln\u00ed biologii a klinickou rehabilitaci. PBM p\u0159i vlnov\u00e9 d\u00e9lce 600-1 100 nm aktivuje zv\u00fd\u0161enou synt\u00e9zu ATP a \u0159\u00edzenou signalizaci ROS prost\u0159ednictv\u00edm CCO, kter\u00e1 aktivuje transkrip\u010dn\u00ed faktory (NF-\u03baB, AP-1, HIF-1\u03b1) a reguluje r\u016fstov\u00e9 faktory (TGF-\u03b2, VEGF, IGF-1). Na \u00farovni tk\u00e1n\u00ed je podporov\u00e1na proliferace fibroblast\u016f a keratinocyt\u016f, polarizace makrof\u00e1g\u016f a synt\u00e9za kolagenu. Nejd\u016fle\u017eit\u011bj\u0161\u00ed doporu\u010den\u00ed d\u00e1vky pro tk\u00e1n\u011b s n\u00edzk\u00fdm obsahem mitochondri\u00ed (k\u016f\u017ee, \u0161lachy): Hustota v\u00fdkonu &lt; 100 mW\/cm\u00b2, hustota energie 4-10 J\/cm\u00b2 v c\u00edlov\u00e9 tk\u00e1ni.<\/p>\n\n\n\n<p><strong>Odhalen\u00ed s\u00edly sv\u011btla na k\u016f\u017ei: komplexn\u00ed p\u0159ehled fotobiomodulace<\/strong><br><em>Int. J. Mol. Sci. (2024)<\/em> <a href=\"https:\/\/www.mdpi.com\/1422-0067\/25\/8\/4483\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>Narativn\u00ed p\u0159ehled klinick\u00fdch studi\u00ed (6 let) o PBM v dermatologii. Nej\u010dast\u011bji se pou\u017e\u00edvala vlnov\u00e1 d\u00e9lka 630-950 nm. Optim\u00e1ln\u00ed pro omlazen\u00ed pleti: 630-660 nm, 6-50 mW\/cm\u00b2, 8-16 J\/cm\u00b2, 3\u00d7 t\u00fddn\u011b. Dvouf\u00e1zov\u00fd \u00fa\u010dinek bikini: Nejlep\u0161\u00ed v\u00fdsledky p\u0159i m\u00edrn\u00fdch a st\u0159edn\u00edch d\u00e1vk\u00e1ch; p\u0159ed\u00e1vkov\u00e1n\u00ed (&gt; 20 J\/cm\u00b2 na povrchu k\u016f\u017ee) m\u016f\u017ee inhibovat synt\u00e9zu kolagenu nam\u00edsto jej\u00ed podpory.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Kollagensynthese_Hautverjungung\"><\/span>Synt\u00e9za kolagenu a omlazen\u00ed pleti<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>Optimalizace n\u00edzko\u00farov\u0148ov\u00e9 sv\u011bteln\u00e9 terapie pro omlazen\u00ed pleti<\/strong><br><em>SCIRP (2025)<\/em> <a href=\"https:\/\/www.scirp.org\/journal\/paperinformation?paperid=142513\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>RCT (split-face) s 830 nm + 633 nm LED. Parametry: 6,4 mW\/cm\u00b2, 8,05 J\/cm\u00b2, 21 minut na sezen\u00ed, 3\u00d7 t\u00fddn\u011b po dobu 4 t\u00fddn\u016f. V\u00fdrazn\u00e1 redukce vr\u00e1sek a zlep\u0161en\u00ed elasticity pleti. Hlavn\u00ed zji\u0161t\u011bn\u00ed: 3 sezen\u00ed t\u00fddn\u011b byla \u00fa\u010dinn\u011bj\u0161\u00ed ne\u017e 2 - frekvence siln\u011b ovlivnila v\u00fdsledek.<\/p>\n\n\n\n<p><strong>Regulace metabolismu kolagenu v k\u016f\u017ei pomoc\u00ed 660 nm LED diody<\/strong><br><em>Journal of Investigative Dermatology (klasick\u00e1 studie)<\/em><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0022202X15341749\" target=\"_blank\" rel=\"noopener\"> Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p><strong>Parametry<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>660 nm, pulzn\u00ed (sekven\u010dn\u00ed pulzn\u00ed re\u017eim LED)<\/li>\n\n\n\n<li>11 setk\u00e1n\u00ed<\/li>\n<\/ul>\n\n\n\n<p><strong>V\u00fdsledky<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>+31% Prokolagen typu 1<\/li>\n\n\n\n<li>-18% MMP-1 v tk\u00e1\u0148ov\u00fdch biopsi\u00edch.<\/li>\n\n\n\n<li>U &gt;90% testovan\u00fdch osob do\u0161lo ke sn\u00ed\u017een\u00ed hloubky vr\u00e1sek.<\/li>\n\n\n\n<li>Pro fotobiologickou \u00fa\u010dinnost byl rozhoduj\u00edc\u00ed sekven\u010dn\u00ed pr\u016fb\u011bh pulz\u016f (nikoli kontinu\u00e1ln\u00ed vlna).<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Klinische_Studien_Wundheilung_JAAD\"><\/span>Klinick\u00e9 studie Hojen\u00ed ran (JAAD)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>Fotobiomodulace CME \u010d\u00e1st II: Klinick\u00e9 aplikace v dermatologii<\/strong><br><em>Journal of the American Academy of Dermatology (2024)<\/em> <a href=\"https:\/\/www.jaad.org\/article\/S0190-9622(24)00187-7\/fulltext\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>Konsensus &gt;20 odborn\u00edk\u016f (JAAD). Parametry pro diabetick\u00e9 v\u0159edy (\u00farove\u0148 d\u016fkazu IA): 630-670 nm, 10-50 mW\/cm\u00b2, 2-6 J\/cm\u00b2, denn\u00ed aplikace nebo 3\u00d7 t\u00fddn\u011b a\u017e do uzav\u0159en\u00ed r\u00e1ny. Metaanal\u00fdza 12 RCT: plocha v\u0159edu -30,9%, -4,2 cm\u00b2 ve srovn\u00e1n\u00ed s kontrolou. Pozitivn\u011b ovlivn\u011bny v\u0161echny f\u00e1ze hojen\u00ed r\u00e1ny (z\u00e1n\u011btliv\u00e1, prolifera\u010dn\u00ed, remodela\u010dn\u00ed).<\/p>\n\n\n\n<p><strong>Vliv terapie PBM (660 nm) na hojen\u00ed ran infikovan\u00fdch zlat\u00fdm stafylokokem<\/strong><br><em>Fotobiomodul Photomed Laser Surg. (2020)<\/em> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32466696\/\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>Studie na zv\u00ed\u0159atech: 660 nm, 35 min\/den, 7 dn\u00ed. V\u00fdrazn\u011b men\u0161\u00ed r\u00e1ny (p &lt; 0,01), v\u00edce granula\u010dn\u00ed tk\u00e1n\u011b, nejvy\u0161\u0161\u00ed obsah kolagenu (stupe\u0148 3+). Markery proliferace PCNA se v\u00fdznamn\u011b zv\u00fd\u0161ily. Pozn\u00e1mka: Intenzita z\u00e1m\u011brn\u011b udr\u017eov\u00e1na na n\u00edzk\u00e9 \u00farovni - u infikovan\u00fdch ran je obzvl\u00e1\u0161t\u011b d\u016fle\u017eit\u00e9 nep\u0159ekra\u010dovat d\u00e1vku (&lt; 15 J\/cm\u00b2).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Muskeln_Sport_Rehabilitation_850_nm\"><\/span>Svaly, sport a rehabilitace (850 nm)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Bl\u00edzk\u00e9 infra\u010derven\u00e9 sv\u011btlo o vlnov\u00e9 d\u00e9lce 850 nm pronik\u00e1 a\u017e do hloubky 50 mm. Podle metaanal\u00fdzy (Baroni et al., 2019) je optim\u00e1ln\u00ed parametr pro svalov\u00e9 aplikace 810 nm, 100 mW\/cm\u00b2, 30 J\/cm\u00b2 - u tr\u00e9novan\u00fdch sportovc\u016f byl nam\u011b\u0159en p\u0159\u00edr\u016fstek s\u00edly 15%. Pokud jsou d\u00e1vky p\u0159\u00edli\u0161 vysok\u00e9 (&gt;50 J\/cm\u00b2, &gt;200 mW\/cm\u00b2), \u00fa\u010dinky se sni\u017euj\u00ed. Studie Leal-Junior et al. (2011) stanovila optim\u00e1ln\u00ed d\u00e1vku pro 810 nm na 30 J celkem (ne J\/cm\u00b2) v pr\u016fb\u011bhu 6 svalov\u00fdch bod\u016f p\u0159ed tr\u00e9ninkem.<\/p>\n\n\n\n<p><strong>Parametry<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Vlnov\u00e1 d\u00e9lka 808-850 nm<\/li>\n\n\n\n<li>Hustota v\u00fdkonu 50-100 mW\/cm\u00b2 (laser); 30-150 mW\/cm\u00b2 (LED panel)<\/li>\n\n\n\n<li>Hustota energie 10-30 J\/cm\u00b2 (sportovci); 6-10 J\/cm\u00b2 (rehabilitace)<\/li>\n\n\n\n<li>Doba trv\u00e1n\u00ed 5-15 min\/svalov\u00e1 skupina<br>Pou\u017eit\u00ed p\u0159\u00edmo p\u0159ed nebo po tr\u00e9ninku<\/li>\n\n\n\n<li>3-7\u00d7 t\u00fddn\u011b pro intenzivn\u00ed tr\u00e9nink; 2-3\u00d7 pro rehabilitaci<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Skelettmuskelregeneration\"><\/span>Regenerace kostern\u00edho svalstva<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>PBMT v regeneraci kostern\u00edho svalstva: komplexn\u00ed p\u0159ehled<\/strong><br><em>Fotodiagnostika a fotodynamick\u00e1 terapie (2025)<\/em> <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1572100025001668\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>Kl\u00ed\u010dov\u00e1 studie (Baroni 2019): 810 nm, 100 mW\/cm\u00b2, 30 J\/cm\u00b2, 6 svalov\u00fdch bod\u016f \u2192 zv\u00fd\u0161en\u00ed s\u00edly 15% u sportovc\u016f. Sn\u00ed\u017een\u00ed IL-6 o 40% s preventivn\u00ed PBM (5 J\/cm\u00b2 na potkan\u00edch holenn\u00edch svalech). Upozorn\u011bn\u00ed: Parametry ze studi\u00ed na zv\u00ed\u0159atech (nap\u0159. 5 J\/cm\u00b2) nelze p\u0159\u00edmo p\u0159en\u00e9st na \u010dlov\u011bka - lidsk\u00fd kvadriceps vy\u017eaduje vy\u0161\u0161\u00ed hustotu energie kv\u016fli v\u011bt\u0161\u00ed hloubce tk\u00e1n\u011b.<\/p>\n\n\n\n<p><strong>PBM v lidsk\u00e9 svalov\u00e9 tk\u00e1ni: v\u00fdhoda p\u0159i sportovn\u00edm v\u00fdkonu?<\/strong><br><em>J. Biophotonics (PMC) (2016)<\/em> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5167494\/\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>Systematick\u00fd p\u0159ehled v\u0161ech RCT (\u00farove\u0148 1b) a studi\u00ed p\u0159\u00edpad\u016f a kontrol (\u00farove\u0148 3b). Nej\u00fa\u010dinn\u011bj\u0161\u00ed parametry pro aplikaci na biceps: 810-850 nm, 50-100 mW\/cm\u00b2, 10-30 J\/cm\u00b2. Nejefektivn\u011bj\u0161\u00ed parametry pro kvadriceps (v\u011bt\u0161\u00ed sval, hlub\u0161\u00ed tk\u00e1\u0148): nutn\u00e9 vy\u0161\u0161\u00ed energie, up\u0159ednost\u0148ov\u00e1ny klastrov\u00e9 aplik\u00e1tory (5 diod). P\u0159edtr\u00e9ninkov\u00e1 aplikace PBM je p\u0159inejmen\u0161\u00edm rovnocenn\u00e1, \u010dasto lep\u0161\u00ed ne\u017e aplikace po tr\u00e9ninku, pokud jde o hodnoty s\u00edly.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Meta-Analysen_Sportleistung_Muskelkater\"><\/span>Metaanal\u00fdzy sportovn\u00edho v\u00fdkonu a svalov\u00e9 bolestivosti<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>\u00da\u010dinky fotomodula\u010dn\u00ed terapie DOMS: systematick\u00fd p\u0159ehled a metaanal\u00fdza<\/strong><br><em>MDPI JFMK (2025)<\/em> <a href=\"https:\/\/www.mdpi.com\/2411-5142\/10\/3\/277\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>14 studi\u00ed, vlnov\u00e9 d\u00e9lky 660-950 nm, 1-6 svalov\u00fdch bod\u016f. Optim\u00e1ln\u00ed pro sn\u00ed\u017een\u00ed DOMS: 830-850 nm, 50-100 mW\/cm\u00b2, 6-10 J\/cm\u00b2 na bod, bezprost\u0159edn\u011b po tr\u00e9ninku. V\u00fdznamn\u00e9 sn\u00ed\u017een\u00ed bolesti podle VAS ve srovn\u00e1n\u00ed s placebem; pozitivn\u00ed \u00fa\u010dinky na udr\u017een\u00ed svalov\u00e9 s\u00edly.<\/p>\n\n\n\n<p><strong>M\u016f\u017ee PBM p\u0159ed cvi\u010den\u00edm zlep\u0161it svalovou vytrvalost a podpo\u0159it regeneraci? Metaanal\u00fdza<\/strong><br><em>Lasery v l\u00e9ka\u0159stv\u00ed (2024)<\/em> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38758297\/\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>Kreatinkin\u00e1za se sn\u00ed\u017eila o 77,56 jednotek (95%-KI: -112,67 a\u017e -42,44, p &lt; 0,01). Nej\u00fa\u010dinn\u011bj\u0161\u00ed parametry: 810 nm, celkov\u00fd v\u00fdkon 200 mW, celkov\u00e1 energie 30 J do 6 bod\u016f kvadricepsu. Dvouf\u00e1zov\u00e9 zji\u0161t\u011bn\u00ed: 50 J celkov\u00e9 energie bylo m\u00e9n\u011b \u00fa\u010dinn\u00e9 ne\u017e 30 J - jasn\u00fd p\u0159\u00edklad Hormesisovy\/Arndtovy-Schulzovy k\u0159ivky.<\/p>\n\n\n\n<p><strong>PBM p\u0159ed cvi\u010den\u00edm (810 nm): Optim\u00e1ln\u00ed v\u00fdkon pro regeneraci sval\u016f<\/strong><br><em>Photomed Laser Surg (2017)<\/em> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29099680\/\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>RCT s 28 fotbalov\u00fdmi sportovci. Srovn\u00e1n\u00ed v\u00fdkonu 100, 200 a 400 mW na diodu (5 diod, 810 nm). V\u00fdsledek: 100 mW\/diodu (500 mW celkem) bylo optim\u00e1ln\u00ed. Vy\u0161\u0161\u00ed v\u00fdkon (200, 400 mW) nevykazoval lep\u0161\u00ed nebo dokonce hor\u0161\u00ed v\u00fdsledky - klasick\u00fd p\u0159\u00edklad: v\u011bt\u0161\u00ed hustota v\u00fdkonu nen\u00ed automaticky lep\u0161\u00ed.<\/p>\n\n\n\n<p><strong>\u00da\u010dinky PBM, IPC a NMES na regeneraci sval\u016f: systematick\u00fd p\u0159ehled<\/strong><br><em>Journal of Bodywork and Movement Therapies (2025)<\/em> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40954632\/\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>19 RCT, 672 \u00fa\u010dastn\u00edk\u016f. PBM p\u0159ed tr\u00e9ninkem sn\u00ed\u017eila bolest o -12,27 bodu (95%-KI -18,14 a\u017e -6,40; I\u00b2 = 48%). PBM byla jedinou metodou (oproti IPC a NMES) s v\u00fdznamn\u00fdm p\u0159\u00ednosem. Doporu\u010den\u00e9 parametry: 810-850 nm, 50-100 mW\/cm\u00b2, 6-10 J\/cm\u00b2.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Gehirn_Kognition_Neurologie_810%E2%80%931064_nm\"><\/span>Mozek, kognice a neurologie (810-1 064 nm)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Transkrani\u00e1ln\u00ed PBM mus\u00ed p\u0159ekonat n\u011bkolik biologick\u00fdch bari\u00e9r (skalp, lebe\u010dn\u00ed kosti, mozkov\u00e9 pleny, mozkom\u00ed\u0161n\u00ed mok, mozkov\u00e1 k\u016fra). Po\u017eadovan\u00e9 hustoty v\u00fdkonu jsou proto v\u00fdrazn\u011b vy\u0161\u0161\u00ed ne\u017e u povrchov\u00fdch aplikac\u00ed. Systematick\u00fd p\u0159ehled z roku 2024 (97 studi\u00ed, 2 133 zdroj\u016f) zjistil: Studie obvykle vyu\u017e\u00edvaj\u00ed ~250 mW\/cm\u00b2 na povrchu - z \u010deho\u017e se do mozkov\u00e9 tk\u00e1n\u011b dostane jen zlomek. Pro korov\u00e9 neurony: optim\u00e1ln\u00ed produkce ATP p\u0159i 25 mW\/cm\u00b2, 3 J\/cm\u00b2. K po\u0161kozen\u00ed mitochondri\u00ed doch\u00e1z\u00ed ji\u017e p\u0159i 30 J\/cm\u00b2 (p\u0159\u00edli\u0161 vysok\u00e1 d\u00e1vka = inhibi\u010dn\u00ed).<\/p>\n\n\n\n<p><strong>Parametry<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Vlnov\u00e1 d\u00e9lka 810 nm (pozn\u00e1v\u00e1n\u00ed\/Alzheimerova choroba), 1 064 nm (hlubok\u00fd pr\u016fnik\/TBI)<\/li>\n\n\n\n<li>Hustota v\u00fdkonu 25-285 mW\/cm\u00b2 na poko\u017ece hlavy (c\u00edlov\u00e1 tk\u00e1\u0148: k\u016fra mozkov\u00e1 dost\u00e1v\u00e1 zlomek t\u00e9to hodnoty).<\/li>\n\n\n\n<li>Hustota energie 20-60 J\/cm\u00b2 (povrch); 3 J\/cm\u00b2 v c\u00edlov\u00e9 tk\u00e1ni (neurony).<\/li>\n\n\n\n<li>Doba trv\u00e1n\u00ed 10-20 min | 3\u00d7 t\u00fddn\u011b (12 t\u00fddn\u016f pro RCT Alzheimerovy choroby)<\/li>\n\n\n\n<li>Nejm\u00e9n\u011b 8-12 t\u00fddn\u016f pro kognitivn\u00ed \u00fa\u010dinky; akutn\u00ed \u00fa\u010dinky od 1-2 t\u00fddn\u016f pro TBI<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Mechanismen_allgemeine_Wirkungen\"><\/span>Mechanismy a obecn\u00e9 \u00fa\u010dinky<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>Fotobiomodula\u010dn\u00ed terapie mozku: revoluce v kognitivn\u00ed dynamice<\/strong><br><em>MDPI Cells (2024)<\/em> <a href=\"https:\/\/www.mdpi.com\/2073-4409\/13\/11\/966\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>PBM aktivuje cytochrom c oxid\u00e1zu v neuron\u00e1ln\u00edch mitochondri\u00edch, zvy\u0161uje BDNF. 810 nm vykazuje siln\u011bj\u0161\u00ed aktivaci CCO ne\u017e 1 064 nm (absorp\u010dn\u00ed p\u00edk CCO p\u0159i ~810 nm). Naopak vlnov\u00e1 d\u00e9lka 1 064 nm m\u00e1 siln\u011bj\u0161\u00ed vliv na Ca\u00b2\u207a kan\u00e1ly. Shoda klinick\u00fdch parametr\u016f: 810 nm, 250 mW\/cm\u00b2 plochy, 20-60 J\/cm\u00b2, transkrani\u00e1ln\u011b na prefront\u00e1ln\u00ed k\u016f\u0159e a sp\u00e1nkov\u00e9m laloku.<\/p>\n\n\n\n<p><strong>P\u0159ehled vypr\u00e1v\u011bn\u00ed o mozku PBM: Mechanismy, d\u00e1vky, budouc\u00ed trendy<\/strong><br><em>PMC (Brain Photobiomodulation Review) (2018)<\/em> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6041198\/\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>Kl\u00ed\u010dov\u00e9 parametry: Kortik\u00e1ln\u00ed neurony (kultivovan\u00e9): 25 mW\/cm\u00b2, optim\u00e1ln\u00ed produkce ATP p\u0159i 3 J\/cm\u00b2. Vy\u0161\u0161\u00ed d\u00e1vky (10 J\/cm\u00b2) stimuluj\u00ed m\u00e9n\u011b, 30 J\/cm\u00b2 vede k po\u0161kozen\u00ed mitochondri\u00ed. Pro hlub\u0161\u00ed oblasti mozku (baz\u00e1ln\u00ed ganglia, mozkov\u00fd kmen u Parkinsonovy choroby): Doporu\u010duje se laser t\u0159\u00eddy 4 (10-15 W) nam\u00edsto t\u0159\u00eddy 3 (&lt;0,5 W), aby se do hloubky dostalo dostate\u010dn\u00e9 mno\u017estv\u00ed z\u00e1\u0159en\u00ed.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Alzheimer_Demenz\"><\/span>Alzheimerova choroba a demence<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>PBM mozku: potenci\u00e1ln\u00ed l\u00e9\u010dba Alzheimerovy a Parkinsonovy choroby<\/strong><br><em>PMC (2025)<\/em> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12321612\/\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>P\u0159edklinick\u00e9 studie: 808-810 nm, pulzn\u00ed (40 Hz), denn\u011b nebo 3\u00d7 t\u00fddn\u011b, 12 t\u00fddn\u016f. Prok\u00e1z\u00e1no sn\u00ed\u017een\u00ed amyloidu beta, ox. Stresu, neuroz\u00e1n\u011btu; lep\u0161\u00ed kognitivn\u00ed v\u00fdsledky na zv\u00ed\u0159ec\u00edm modelu. Klinick\u00e1 studie (Japonsko): pulzn\u00ed sv\u011btlo 810 nm (40 Hz), 3\u00d7 t\u00fddn\u011b, 12 t\u00fddn\u016f, v\u00fdsledek: v\u00fdznamn\u011b lep\u0161\u00ed sk\u00f3re ADAS-Cog.<\/p>\n\n\n\n<p><strong>Transkrani\u00e1ln\u00ed PBM u Alzheimerovy choroby: protokol RCT (Japonsko)<\/strong><br><em>Frontiers in Neurology (2024)<\/em> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11258032\/\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>Pln\u011b popsan\u00e9 parametry RCT: 810 nm, pulzn\u00ed 40 Hz, 250 mW\/cm\u00b2, 20 min\/sezen\u00ed, 3\u00d7 t\u00fddn\u011b, 12 t\u00fddn\u016f. M\u011b\u0159en\u00ed EEG prok\u00e1zala zlep\u0161en\u00ed alfa\/beta\/gama rytmu. Prim\u00e1rn\u00ed c\u00edlov\u00fd ukazatel ADAS-Cog (Alzheimer's Cognition Scale). Prospektivn\u00ed studie kontrolovan\u00e1 fale\u0161n\u00fdmi testy.<\/p>\n\n\n\n<p><strong>Transkrani\u00e1ln\u00ed PBM zlep\u0161uje kognitivn\u00ed funkce, posttraumatickou stresovou poruchu a post-ot\u0159esov\u00e9 symptomy<\/strong><br><em>\u010casopis Journal of Neurotrauma (2025)<\/em> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40485299\/\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>RCT, 17 pacient\u016f s TBI. Parametry: 810 nm nebo 1 064 nm, 250 mW\/cm\u00b2, 20 J\/cm\u00b2, 10 min\/sezen\u00ed. V\u00fdznamn\u00e9 zlep\u0161en\u00ed kognitivn\u00edch funkc\u00ed, posttraumatick\u00e9 stresov\u00e9 poruchy a symptom\u016f po ot\u0159esu mozku. Kontrolov\u00e1no placebem.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"TBI_Entgiftung_1064_nm\"><\/span>TBI a detoxikace (1 064 nm)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>1064 nm PBM podporuje zotaven\u00ed po TBI prost\u0159ednictv\u00edm modulace neuroz\u00e1n\u011btu<\/strong><br><em>Journal of Translational Medicine (2025)<\/em> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41204266\/\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>Model my\u0161i: 1 064 nm LED, 25 mW\/cm\u00b2, 12 min\/den (= 18 J\/cm\u00b2), 14 dn\u00ed. V\u00fdrazn\u00e9 zotaven\u00ed po TBI, zm\u00edrn\u011bn\u00ed kognitivn\u00edch a emo\u010dn\u00edch poruch. BDNF a VEGF se v o\u0161et\u0159ovan\u00e9 oblasti v\u00fdznamn\u011b zv\u00fd\u0161ily. Mechanismus: Modulace polarizace mikroglie a neuroz\u00e1n\u011btu.<\/p>\n\n\n\n<p><strong>PBM a glymfatick\u00fd syst\u00e9m: pos\u00edlen\u00ed lymfatick\u00e9 dren\u00e1\u017ee mozku<\/strong><br><em>Int. J. Mol. Sci. (2022)<\/em> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8950470\/\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>Studie na zv\u00ed\u0159atech: PBM (810 nm, 25-50 mW\/cm\u00b2) zlep\u0161uje pr\u016ftok meninge\u00e1ln\u00ed lymfy, podporuje clearance amyloidu beta prost\u0159ednictv\u00edm glymfatick\u00e9ho syst\u00e9mu. Terapeutick\u00fd v\u00fdznam: Detoxika\u010dn\u00ed funkce mozku - d\u016fle\u017eit\u00e9 pro prevenci Alzheimerovy choroby a celkov\u00e9 zdrav\u00ed mozku.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Schmerzmanagement\"><\/span>L\u00e9\u010dba bolesti<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>PBM m\u00e1 analgetick\u00fd \u00fa\u010dinek prost\u0159ednictv\u00edm n\u011bkolika mechanism\u016f: sn\u00ed\u017een\u00ed proz\u00e1n\u011btliv\u00fdch cytokin\u016f (TNF-\u03b1, IL-6, IL-1\u03b2), modulace nociceptivn\u00edch C a A\u03b4 vl\u00e1ken, zv\u00fd\u0161en\u00ed uvol\u0148ov\u00e1n\u00ed endorfinu a zlep\u0161en\u00ed lok\u00e1ln\u00ed mikrocirkulace. Pro povrchov\u00e9 bolestiv\u00e9 body (citliv\u00e9 body, spou\u0161\u0165ov\u00e9 body): posta\u010duje vlnov\u00e1 d\u00e9lka 630-660 nm. Pro hlub\u0161\u00ed muskuloskelet\u00e1ln\u00ed struktury (klouby, p\u00e1te\u0159): 780-905 nm s vy\u0161\u0161\u00ed hustotou v\u00fdkonu.<\/p>\n\n\n\n<p><strong>Parametry<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Vlnov\u00e1 d\u00e9lka 630-905 nm (v z\u00e1vislosti na hloubce bolestiv\u00e9ho m\u00edsta)<\/li>\n\n\n\n<li>Hustota v\u00fdkonu 40-100 mW\/cm\u00b2 (povrchov\u00e1: 40-60; hlubok\u00e1: 60-100)<\/li>\n\n\n\n<li>Hustota energie 4-10 J\/cm\u00b2 na bod (u fibromyalgie: a\u017e 150 J\/cm\u00b2 na cel\u00e9 t\u011blo).<\/li>\n\n\n\n<li>Doba trv\u00e1n\u00ed 10-20 min\/sezen\u00ed<\/li>\n\n\n\n<li>Frekvence 3\u00d7 t\u00fddn\u011b, 6-12 t\u00fddn\u016f; fibromyalgie: 4-6 t\u00fddn\u016f intenzivn\u00ed + n\u00e1sledn\u00e1 p\u00e9\u010de.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Ubergreifende_Reviews\"><\/span>Komplexn\u00ed recenze<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>\u00da\u010dinky PBM na v\u00edce zdravotn\u00edch v\u00fdsledk\u016f: souhrnn\u00fd p\u0159ehled RCT<\/strong><br><em>Systematick\u00e9 p\u0159ehledy (Springer) (2025)<\/em> <a href=\"https:\/\/link.springer.com\/article\/10.1186\/s13643-025-02902-3\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>15 metaanal\u00fdz, &gt;9 000 pacient\u016f, 35 koncov\u00fdch bod\u016f, 15 onemocn\u011bn\u00ed. Nejsiln\u011bj\u0161\u00ed d\u016fkazy pro fibromyalgii, posti\u017een\u00ed kolenn\u00ed osteoartr\u00f3zy a kognitivn\u00ed poruchy. Protokoly PBM se velmi li\u0161ily - neexistuje jednotn\u00fd standard, co\u017e zt\u011b\u017euje srovnatelnost. Kvalita GRADE: 17% st\u0159edn\u011b vysok\u00e1, 57% n\u00edzk\u00e1, 26% velmi n\u00edzk\u00e1.<\/p>\n\n\n\n<p><strong>PBM u chronick\u00e9 bolesti: systematick\u00fd p\u0159ehled RCT<\/strong><br><em>Frontiers in Integrative Neuroscience (2026)<\/em> <a href=\"https:\/\/www.frontiersin.org\/journals\/integrative-neuroscience\/articles\/10.3389\/fnint.2026.1717372\/full\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>14 RCT, 6 611 \u010dl\u00e1nk\u016f. Nejsiln\u011bj\u0161\u00ed v\u00fdsledky u fibromyalgie a perifern\u00edch neuropati\u00ed: v\u00fdznamn\u00e9 sn\u00ed\u017een\u00ed VAS (p = 0,010), v\u00fdznamn\u00e9 sn\u00ed\u017een\u00ed citliv\u00fdch bod\u016f (p &lt; 0,0001). Doporu\u010den\u00e9 parametry pro neuropatickou bolest: 660-830 nm, 40-80 mW\/cm\u00b2, 4-6 J\/cm\u00b2, 3\u00d7 t\u00fddn\u011b.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Fibromyalgie\"><\/span>Fibromyalgie<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>\u00da\u010dinnost PBMT u fibromyalgie: systematick\u00fd p\u0159ehled (17 studi\u00ed)<\/strong><br><em>MDPI Applied Sciences (2025)<\/em> <a href=\"https:\/\/www.mdpi.com\/2076-3417\/15\/8\/4161\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>857 \u00fa\u010dastn\u00edk\u016f. Pou\u017eit\u00e1 za\u0159\u00edzen\u00ed: n\u00edzko\u00farov\u0148ov\u00fd laser, infra\u010derven\u00e1 LED, celot\u011blov\u00e1 sv\u011bteln\u00e1 l\u016f\u017eka (NovoTHOR). Celot\u011blov\u00e1 PBM (630-1 100 nm, variabiln\u00ed fluence 1-150 J\/cm\u00b2) byla p\u0159inejmen\u0161\u00edm rovnocenn\u00e1 lok\u00e1ln\u00ed PBM. Mechanismus: Modulace oxida\u010dn\u00edho stresu, mitochondri\u00e1ln\u00ed funkce a nociceptivn\u00edch sign\u00e1ln\u00edch drah. Doporu\u010den\u00ed: U roz\u0161\u00ed\u0159en\u00fdch bolestiv\u00fdch bod\u016f se up\u0159ednost\u0148uje celot\u011blov\u00fd p\u0159\u00edstup.<\/p>\n\n\n\n<p><strong>Celot\u011blov\u00e1 PBM na bolest, QoL, kineziofobii: trojit\u011b zaslepen\u00e1 RCT, 6 m\u011bs\u00edc\u016f sledov\u00e1n\u00ed<\/strong><br><em>Frontiers in Neuroscience (2024)<\/em> <a href=\"https:\/\/www.frontiersin.org\/journals\/neuroscience\/articles\/10.3389\/fnins.2024.1264821\/full\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>42 pacient\u016f, celot\u011blov\u00e9 l\u016f\u017eko NovoTHOR (660 + 850 nm, vlastn\u00ed hustota v\u00fdkonu). 12 l\u00e9\u010debn\u00fdch sezen\u00ed. V\u00fdznamn\u00e9 sn\u00ed\u017een\u00ed bolesti v T2 (po l\u00e9\u010db\u011b), T3 (2t\u00fddenn\u00ed sledov\u00e1n\u00ed) a T4\/T5 (3 a 6 m\u011bs\u00edc\u016f). Celot\u011blov\u00e1 PBM \u0159e\u0161\u00ed syst\u00e9movou patologii fibromyalgie \u00fa\u010dinn\u011bji ne\u017e selektivn\u00ed aplikace.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Kniearthrose_Tendinopathie\"><\/span>Osteoartr\u00f3za kolene a tendinopatie<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>PBM u osteoartr\u00f3zy kolenn\u00edho kloubu: systematick\u00fd p\u0159ehled a metaanal\u00fdza (10 RCT)<\/strong><br><em>Fyzik\u00e1ln\u00ed terapie (2024)<\/em> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38775202\/\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>542 \u00fa\u010dastn\u00edk\u016f. Nej\u00fa\u010dinn\u011bj\u0161\u00ed parametry: 810-830 nm, 50-100 mW\/cm\u00b2, 4-10 J\/cm\u00b2 na prostor kolenn\u00edho kloubu, 10-20 min, 3\u00d7 t\u00fddn\u011b. M\u00edrn\u00e9 d\u016fkazy o sn\u00ed\u017een\u00ed bolesti a zlep\u0161en\u00ed funk\u010dnosti. Pozn\u00e1mka: Kolenn\u00ed kloub je hloub\u011bji ne\u017e povrch k\u016f\u017ee - proto se up\u0159ednost\u0148uje vlnov\u00e1 d\u00e9lka 810-850 nm (hlub\u0161\u00ed pr\u016fnik) p\u0159ed 660 nm.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Neuropathischer_Schmerz\"><\/span>Neuropatick\u00e1 bolest<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>PBM u neuropatick\u00e9 bolesti: mechanismy, d\u016fkazy a budouc\u00ed sm\u011bry<\/strong><br><em>Hranice fotoniky (2025)<\/em> <a href=\"https:\/\/www.frontiersin.org\/journals\/photonics\/articles\/10.3389\/fphot.2025.1730347\/full\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>660 nm aktivuje jin\u00e9 fotoakceptory ne\u017e 810-850 nm. Pro povrchovou neuropatii (nap\u0159. postherpetick\u00e1 neuralgie): 660 nm, 20-50 mW\/cm\u00b2, 4-6 J\/cm\u00b2. Pro hlubokou neuropatii (nap\u0159. diabetick\u00e1 polyneuropatie nohou): 810-830 nm, 50-100 mW\/cm\u00b2, 6-10 J\/cm\u00b2. Mechanismus: PBM navozuje neuroprotekci prost\u0159ednictv\u00edm synt\u00e9zy BDNF a potla\u010den\u00ed neuroz\u00e1n\u011btu.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Augenheilkunde_AMD\"><\/span>Oftalmologie (AMD)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Pro o\u010dn\u00ed aplikace (zejm\u00e9na u AMD) plat\u00ed zvl\u00e1\u0161tn\u00ed pravidla d\u00e1vkov\u00e1n\u00ed: Oza\u0159ovac\u00ed v\u00fdkon s\u00edtnice (to, co skute\u010dn\u011b dos\u00e1hne s\u00edtnice) je v\u00fdrazn\u011b ni\u017e\u0161\u00ed ne\u017e hustota v\u00fdkonu za\u0159\u00edzen\u00ed. Za\u0159\u00edzen\u00ed, jako jsou fotobiomodula\u010dn\u00ed br\u00fdle (LumiThera), vyza\u0159uj\u00ed sv\u011btlo p\u0159es zornici - p\u0159\u00edmo na makulu. Proto m\u016f\u017ee sta\u010dit pouh\u00fdch 0,3-15 \u03bcW\/cm\u00b2 oz\u00e1\u0159en\u00ed s\u00edtnice. Upozorn\u011bn\u00ed: Nespr\u00e1vn\u00e9 d\u00e1vkov\u00e1n\u00ed m\u016f\u017ee zp\u016fsobit po\u0161kozen\u00ed s\u00edtnice. Pou\u017e\u00edvejte pouze schv\u00e1len\u00e9 oftalmologick\u00e9 p\u0159\u00edstroje PBM!<\/p>\n\n\n\n<p><strong>Parametry<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Vlnov\u00e1 d\u00e9lka 590 nm + 660 nm + 850 nm (v\u00edce vlnov\u00fdch d\u00e9lek, nap\u0159. LIGHTSITE III)<\/li>\n\n\n\n<li>Hustota v\u00fdkonu 0,3-15 \u03bcW\/cm\u00b2 (s\u00edtnice); povrch za\u0159\u00edzen\u00ed ~600 \u03bcW\/cm\u00b2<\/li>\n\n\n\n<li>Velmi n\u00edzk\u00e1 hustota energie, pe\u010dliv\u011b kalibrovan\u00e1<\/li>\n\n\n\n<li>Doba trv\u00e1n\u00ed 3-10 min\/sezen\u00ed, 3\u00d7 t\u00fddn\u011b po dobu 3-13 m\u011bs\u00edc\u016f<\/li>\n\n\n\n<li>Dlouhodob\u00e9 pou\u017e\u00edv\u00e1n\u00ed; kontrola ka\u017ed\u00e9 3 m\u011bs\u00edce<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Altersbedingte_Makuladegeneration\"><\/span>V\u011bkem podm\u00edn\u011bn\u00e1 makul\u00e1rn\u00ed degenerace<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>LIGHTSITE III: PBM (590+660+850 nm) se such\u00fdm AMD<\/strong><br><em>RETINA Journal (2024)<\/em> <a href=\"https:\/\/journals.lww.com\/retinajournal\/fulltext\/2024\/03000\/lightsite_iii__13_month_efficacy_and_safety.14.aspx\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>100 pacient\u016f, 10 americk\u00fdch center, 13 m\u011bs\u00edc\u016f. Za\u0159\u00edzen\u00ed: LumiThera Valeda Light Delivery System. Vlnov\u00e9 d\u00e9lky: postupn\u011b 590 + 660 + 850 nm. L\u00e9\u010dba: 3\u00d7 t\u00fddn\u011b po dobu 3 m\u011bs\u00edc\u016f, pot\u00e9 opakovan\u00e9 l\u00e9\u010debn\u00e9 cykly. V\u00fdsledek: Zrakov\u00e1 ostrost +5,4 p\u00edsmene (ETDRS) oproti fale\u0161n\u00e9, &lt;1% nov\u00e9 geografick\u00e9 atrofie oproti 9,8% ve fale\u0161n\u00e9m rameni - statisticky vysoce v\u00fdznamn\u00e9.<\/p>\n\n\n\n<p><strong>PBM4AMD: Kr\u00e1tkodob\u00e1 \u00fa\u010dinnost u \u010dasn\u00e9\/st\u0159edn\u00ed formy AMD<\/strong><br><em>Oko (p\u0159\u00edroda) (2024)<\/em> <a href=\"https:\/\/www.nature.com\/articles\/s41433-024-03326-4\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>38 \u00fa\u010dastn\u00edk\u016f, 12 t\u00fddn\u016f. Parametry: 10 min\/sezen\u00ed, 3\u00d7 t\u00fddn\u011b. Zrakov\u00e1 ostrost, kontrastn\u00ed citlivost a adaptace na tmu se v\u00fdznamn\u011b zlep\u0161ily. Bezpe\u010dnost: \u017e\u00e1dn\u00e9 tepeln\u00e9 ani struktur\u00e1ln\u00ed vedlej\u0161\u00ed \u00fa\u010dinky na s\u00edtnici.<\/p>\n\n\n\n<p><strong>Pou\u017eit\u00ed PBM v oftalmologii: od stolu k l\u016f\u017eku pacienta<\/strong><br><em>Frontiers in Ophthalmology (2024)<\/em> <a href=\"https:\/\/www.frontiersin.org\/journals\/ophthalmology\/articles\/10.3389\/fopht.2024.1388602\/full\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>Vysv\u011btluje slo\u017eitou situaci s parametry v oftalmologii: rozhoduj\u00edc\u00ed je oz\u00e1\u0159en\u00ed s\u00edtnice, nikoli v\u00fdkon p\u0159\u00edstroje. R\u016fzn\u00e9 studie AMD s vlnovou d\u00e9lkou 630 nm prok\u00e1zaly v\u00fdznamn\u00e9 zlep\u0161en\u00ed stavu s\u00edtnice ji\u017e p\u0159i 15 \u03bcW\/cm\u00b2. \u017d\u00e1dn\u00e9 vedlej\u0161\u00ed \u00fa\u010dinky po dobu 15 let p\u0159i spr\u00e1vn\u00e9m d\u00e1vkov\u00e1n\u00ed - d\u016fle\u017eit\u00e9: pou\u017e\u00edvejte pouze kalibrovan\u00e9 l\u00e9ka\u0159sk\u00e9 p\u0159\u00edstroje se schv\u00e1len\u00edm pro konkr\u00e9tn\u00ed o\u010di.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Onkologie_Mukositis\"><\/span>Onkologie a mukozitida<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Z\u00e1n\u011bt \u00fastn\u00ed sliznice je nej\u010dast\u011bj\u0161\u00edm akutn\u00edm vedlej\u0161\u00edm \u00fa\u010dinkem chemoterapie\/radioterapie. PBM se aplikuje intraor\u00e1ln\u011b na \u00fastn\u00ed sliznici jako preventivn\u00ed opat\u0159en\u00ed (p\u0159ed a b\u011bhem protin\u00e1dorov\u00e9 l\u00e9\u010dby). Podle pokyn\u016f MASCC\/ISOO (2019) je PBM jedinou nefarmakologickou intervenc\u00ed s form\u00e1ln\u00edm doporu\u010den\u00edm (\u00farove\u0148 A) pro prevenci mukozitidy p\u0159i transplantaci krvetvorn\u00fdch kmenov\u00fdch bun\u011bk. Vlnov\u00e1 d\u00e9lka a d\u00e1vkov\u00e1n\u00ed jsou v t\u00e9to oblasti nejv\u00edce standardizovan\u00e9.<\/p>\n\n\n\n<p><strong>Parametry<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Vlnov\u00e1 d\u00e9lka 630-660 nm (intraor\u00e1ln\u00ed); 650 + 980 nm (kombinovan\u00e1 intra+extraor\u00e1ln\u00ed)<\/li>\n\n\n\n<li>Hustota v\u00fdkonu 10-25 mW\/cm\u00b2 (MASCC\/ISOO doporu\u010duje InGaAlP lasery 10-25 mW)<\/li>\n\n\n\n<li>Hustota energie 2-6 J\/cm\u00b2 na bod sliznice<\/li>\n\n\n\n<li>Doba trv\u00e1n\u00ed 3-5 min\/bod<br>Pou\u017e\u00edvejte denn\u011b nebo st\u0159\u00eddav\u011b b\u011bhem l\u00e9\u010dby rakoviny<\/li>\n\n\n\n<li>Frekvence Denn\u011b b\u011bhem chemoterapie\/radioterapie; nejm\u00e9n\u011b 5\u00d7 t\u00fddn\u011b<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Leitlinien\"><\/span>Pokyny<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>Pokyny pro klinickou praxi MASCC\/ISOO pro PBM a \u00fastn\u00ed mukozitidu<\/strong><br><em>Podp\u016frn\u00e1 p\u00e9\u010de pro onkologicky nemocn\u00e9 (2019)<\/em> <a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00520-019-04890-2\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>Form\u00e1ln\u00ed doporu\u010den\u00ed (nejvy\u0161\u0161\u00ed \u00farove\u0148 d\u016fkaz\u016f): Vlnov\u00e1 d\u00e9lka 632-685 nm (He-Ne nebo InGaAlP), v\u00fdkon 10-25 mW, hustota energie 2-4 J\/cm\u00b2 na bod aplikace, intraor\u00e1ln\u011b na nemocn\u00e9 oblasti. Frekvence: denn\u011b b\u011bhem chemoterapie. Pou\u017e\u00edv\u00e1 se pro: transplantaci krvetvorn\u00fdch kmenov\u00fdch bun\u011bk, chemoradioterapii hlavy a krku. \u017d\u00e1dn\u00e9 v\u00fdznamn\u00e9 vedlej\u0161\u00ed \u00fa\u010dinky po 15 letech sledov\u00e1n\u00ed.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Chemotherapie-induzierte_Mukositis\"><\/span>Chemoterapi\u00ed vyvolan\u00e1 mukozitida<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>Preventivn\u00ed PBM u chemoterapi\u00ed vyvolan\u00e9 mukozitidy dutiny \u00fastn\u00ed: systematick\u00fd p\u0159ehled RCTs<\/strong><br><em>MDPI Biomedicines (2025)<\/em> <a href=\"https:\/\/www.mdpi.com\/2227-9059\/13\/2\/268\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>13 studi\u00ed, 828 pacient\u016f. Pou\u017eit\u00e9 parametry: 630-660 nm InGaAlP diodov\u00fd laser, 10-25 mW, 2-6 J\/cm\u00b2, denn\u011b intraor\u00e1ln\u011b. U 211 vs. 128 pacient\u016f se vyvinula mukozitida (kontrola vs. PBM). 85% studi\u00ed m\u011blo n\u00edzk\u00e9 riziko zkreslen\u00ed. Preventivn\u00ed PBM v\u00fdznamn\u011b lep\u0161\u00ed ne\u017e reaktivn\u00ed l\u00e9\u010dba.<\/p>\n\n\n\n<p><strong>Prekondicionov\u00e1n\u00ed PBM p\u0159i z\u00e1n\u011btu \u00fastn\u00ed sliznice: dvojit\u011b zaslepen\u00e1 RCT<\/strong><br><em>BMC Oral Health (2025)<\/em> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11800611\/\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>45 pacient\u016f, 3 skupiny. Skupina 2: intraor\u00e1ln\u00ed 650 nm (4 J\/cm\u00b2). Skupina 3: intraor\u00e1ln\u00ed 650 nm + extraor\u00e1ln\u00ed 980 nm. Ob\u011b interven\u010dn\u00ed skupiny vykazovaly v\u00fdznamnou prevenci mukozitidy a xerostomie. V\u00fdsledek: Kombinace \u010derven\u00e9ho + infra\u010derven\u00e9ho sv\u011btla (650 + 980 nm) maxim\u00e1ln\u011b \u00fa\u010dinn\u00e1 pro celkov\u00e9 pokryt\u00ed \u00fast.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Kopf-Hals-Karzinome_Strahlentherapie\"><\/span>Rakovina hlavy a krku a radioterapie<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>PBM pro l\u00e9\u010dbu z\u00e1n\u011btu \u00fastn\u00ed sliznice u rakoviny hlavy a krku: Metaanal\u00fdza 14 RCT<\/strong><br><em>Hlava a krk (Wiley) (2024)<\/em> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38265122\/\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>869 pacient\u016f. Anal\u00fdza parametr\u016f: He-Ne a InGaAlP laser (630-660 nm), 10-25 mW, 2-6 J\/cm\u00b2, denn\u00ed aplikace b\u011bhem radioterapie vykazovala nejlep\u0161\u00ed v\u00fdsledky. Relativn\u00ed sn\u00ed\u017een\u00ed rizika mukozitidy: RR = 0,49 (p = 0,04) od 2. t\u00fddne. Sn\u00ed\u017een\u00ed bolesti: WMD = -1,09 (p &lt; 0,00001). Vysoce v\u00fdznamn\u00e1 \u00fa\u010dinnost po dobu 7 t\u00fddn\u016f radioterapie.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Immunsystem_Entzundung\"><\/span>Imunitn\u00ed syst\u00e9m a z\u00e1n\u011bt<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>PBM ovliv\u0148uje imunitn\u00ed syst\u00e9m v z\u00e1vislosti na kontextu: V z\u00e1n\u011btliv\u00e9 tk\u00e1ni m\u00e1 protiz\u00e1n\u011btliv\u00fd \u00fa\u010dinek (sni\u017euje TNF-\u03b1, IL-6, IL-1\u03b2; podporuje polarizaci makrof\u00e1g\u016f M2), ve zdrav\u00e9 tk\u00e1ni m\u00e1 stimula\u010dn\u00ed \u00fa\u010dinek. Imunomodula\u010dn\u00ed \u00fa\u010dinek byl prok\u00e1z\u00e1n v optick\u00e9m okn\u011b (650-950 nm), s d\u00e1vkov\u00fdm koridorem 1-10 J\/cm\u00b2. D\u016fle\u017eit\u00e9: Tyto d\u00e1vky jsou v\u00fdrazn\u011b ni\u017e\u0161\u00ed ne\u017e u svalov\u00fdch aplikac\u00ed - imunitn\u00ed syst\u00e9m reaguje citliv\u011bji.<\/p>\n\n\n\n<p><strong>Parametry<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Vlnov\u00e1 d\u00e9lka 650-950 nm (nej\u0161ir\u0161\u00ed \u00fa\u010dinn\u00e9 spektrum; doporu\u010den\u00e1 kombinace 660 + 850 nm)<\/li>\n\n\n\n<li>Hustota v\u00fdkonu 20-80 mW\/cm\u00b2<\/li>\n\n\n\n<li>Hustota energie 1-10 J\/cm\u00b2 (imunomodulace)<br>Vy\u0161\u0161\u00ed d\u00e1vky mohou m\u00edt imunosupresivn\u00ed \u00fa\u010dinek.<\/li>\n\n\n\n<li>Doba trv\u00e1n\u00ed 5-15 min\/sezen\u00ed<\/li>\n\n\n\n<li>3\u00d7 t\u00fddn\u011b; p\u0159i akutn\u00edm z\u00e1n\u011btu v prvn\u00edm t\u00fddnu denn\u011b<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Immunmodulation\"><\/span>Imunomodulace<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>Imunomodula\u010dn\u00ed \u00fa\u010dinky PBM: komplexn\u00ed p\u0159ehled<\/strong><br><em>Lasery v l\u00e9ka\u0159stv\u00ed (2025)<\/em> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11991943\/\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>Optim\u00e1ln\u00ed parametry pro imunomodulaci: 650-950 nm, 20-80 mW\/cm\u00b2, 1-10 J\/cm\u00b2. PBM ovliv\u0148uje dendritick\u00e9 bu\u0148ky (migrace, produkce cytokin\u016f), podporuje polarizaci makrof\u00e1g\u016f M2 a reguluje odpov\u011bdi T-bun\u011bk. D\u016fle\u017eit\u00e9 zji\u0161t\u011bn\u00ed: Pouh\u00fd 1 J\/cm\u00b2 sta\u010d\u00ed k m\u011b\u0159iteln\u00fdm imunologick\u00fdm \u00fa\u010dink\u016fm - co\u017e je mnohem m\u00e9n\u011b ne\u017e d\u00e1vky doporu\u010den\u00e9 pro svaly\/kosti.<\/p>\n\n\n\n<p><strong>\u00da\u010dinnost l\u00e9\u010dby PBM p\u0159i l\u00e9\u010db\u011b bolesti a z\u00e1n\u011btu: p\u0159ehled literatury<\/strong><br><em>PMC (2023)<\/em> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10094541\/\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>PBM 600-1 070 nm, hustota energie 1-150 J\/cm\u00b2. Optim\u00e1ln\u00ed pro potla\u010den\u00ed z\u00e1n\u011btu: 780-950 nm, 40-80 mW\/cm\u00b2, 4-10 J\/cm\u00b2, 3\u00d7 t\u00fddn\u011b. Celot\u011blov\u00e1 PBM prok\u00e1zala syst\u00e9mov\u00e9 imunitn\u00ed \u00fa\u010dinky: zlep\u0161en\u00ed kvality sp\u00e1nku, rann\u00ed ztuhlost, sn\u00ed\u017een\u00ed svalov\u00fdch k\u0159e\u010d\u00ed, psychologick\u00e9 faktory. Zvl\u00e1\u0161t\u011b d\u016fle\u017eit\u00e9 u chronick\u00fdch z\u00e1n\u011btliv\u00fdch syst\u00e9mov\u00fdch onemocn\u011bn\u00ed (nap\u0159. fibromyalgie, RA).<\/p>\n\n\n\n<p><strong>P\u0159ehled sv\u011bteln\u00fdch parametr\u016f a \u00fa\u010dinnosti PBM (Hamblin, Harvard)<\/strong><br><em>J. Biomed. Optics (PMC) (2021)<\/em> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8355782\/\" target=\"_blank\" rel=\"noopener\">Cel\u00fd text \/ PubMed<\/a><\/p>\n\n\n\n<p>Z\u00e1kladn\u00ed pr\u00e1ce na ur\u010den\u00ed parametr\u016f (Hamblin\/Harvard). Hlavn\u00ed prohl\u00e1\u0161en\u00ed: Neexistuje v\u0161eobecn\u00e1 shoda ohledn\u011b optim\u00e1ln\u00edch parametr\u016f - hustota v\u00fdkonu &lt; 100 mW\/cm\u00b2 a hustota energie 4-10 J\/cm\u00b2 v c\u00edlov\u00e9 tk\u00e1ni jsou pova\u017eov\u00e1ny za konsenzus pro konzervativn\u00ed doporu\u010den\u00ed. Dvouf\u00e1zov\u00e1 d\u00e1vkov\u00e1 odezva (Arndt-Schulz): stimulace bun\u011bk mezi 0,5-10 J\/cm\u00b2, inhibice nad ~30 J\/cm\u00b2. Tk\u00e1n\u011b s vysok\u00fdm obsahem mitochondri\u00ed (sval, nerv, srdce, mozek) vy\u017eaduj\u00ed v\u00edce energie ne\u017e tk\u00e1n\u011b s n\u00edzk\u00fdm obsahem mitochondri\u00ed (k\u016f\u017ee, \u0161lachy, chrupavky).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Klinische_Empfehlungen\"><\/span>Klinick\u00e1 doporu\u010den\u00ed<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Fotobiomodulace je prvn\u00ed neinvazivn\u00ed l\u00e9\u010debnou metodou s prok\u00e1zanou klinickou \u00fa\u010dinnost\u00ed v nejm\u00e9n\u011b 7 r\u016fzn\u00fdch l\u00e9ka\u0159sk\u00fdch oborech. S\u00edla d\u016fkaz\u016f se li\u0161\u00ed: Nejsiln\u011bj\u0161\u00ed \u00fadaje se t\u00fdkaj\u00ed z\u00e1n\u011btu \u00fastn\u00ed sliznice (sm\u011brnice MASCC\/ISOO), hojen\u00ed ran (metaanal\u00fdzy LoE I) a regenerace sval\u016f ve sportu. Oblasti mozku\/neurologie a AMD jsou velmi slibn\u00e9, ale st\u00e1le se vyv\u00edjej\u00ed.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Allgemeine_Dosierungsregeln_Konsensus\"><\/span>Obecn\u00e1 pravidla d\u00e1vkov\u00e1n\u00ed (konsenzus)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>Absorbovan\u00e1 d\u00e1vka<\/strong><br>5-50 joul\u016f celkem za sezen\u00ed (doporu\u010den\u00ed: ~25 J)<\/p>\n\n\n\n<p><strong>Vlnov\u00e1 d\u00e9lka na c\u00edl<\/strong><br>660 nm pro k\u016f\u017ei\/povrch<br>810-850 nm pro svaly\/klouby\/hlubok\u00e9 tk\u00e1n\u011b<br>1 050-1 064 nm pro mozek<\/p>\n\n\n\n<p><strong>Hustota v\u00fdkonu na hloubku<\/strong><br>K\u016f\u017ee 6-50 mW\/cm\u00b2<br>Svaly 50-100 mW\/cm\u00b2<br>Mozek (transkrani\u00e1ln\u00ed) 25-285 mW\/cm\u00b2<\/p>\n\n\n\n<p><strong>Pozorujte bif\u00e1zii<\/strong><br>Vy\u0161\u0161\u00ed d\u00e1vky nejsou automaticky lep\u0161\u00ed.<br>- K\u016f\u017ee: max. 20 J\/cm\u00b2<br>- Neurony: max. 10 J\/cm\u00b2 na c\u00edlovou tk\u00e1\u0148<br>- pro svaly: max. 30-50 J\/cm\u00b2<\/p>\n\n\n\n<p><strong>Kombinovan\u00e1 za\u0159\u00edzen\u00ed<\/strong> - 660 + 850 nm nab\u00edzej\u00ed nej\u0161ir\u0161\u00ed spektrum; vy\u017eaduj\u00ed ~ 50% del\u0161\u00ed dobu o\u0161et\u0159en\u00ed<\/p>\n\n\n\n<p><strong>Interval l\u00e9\u010dby<\/strong><br>Denn\u011b a\u017e 3\u00d7 t\u00fddn\u011b; doporu\u010duje se p\u0159est\u00e1vka ka\u017ed\u00e9 1-2 dny pro obnovu bun\u011bk.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Evidenzstarke_nach_Bereich\"><\/span>S\u00edla d\u016fkaz\u016f podle oblast\u00ed<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>Velmi siln\u00fd (LoE I, pokyny WALT\/MASCC)<\/strong><br>- Mukozitida u n\u00e1dorov\u00fdch onemocn\u011bn\u00ed<br>- Hojen\u00ed ran<br>- Kolagen\/k\u016f\u017ee<\/p>\n\n\n\n<p><strong>Siln\u00e9 (LoE I, metaanal\u00fdzy)<\/strong><br>- Regenerace sval\u016f<br>- Fibromyalgie<br>- AMD<\/p>\n\n\n\n<p><strong>M\u00edrn\u00e1 (LoE II, RCT)<\/strong><br>- Osteoartr\u00f3za kolene<br>- neuropatick\u00e1 bolest<br>- Pozn\u00e1v\u00e1n\u00ed (transkrani\u00e1ln\u00ed)<\/p>\n\n\n\n<p><strong>Ran\u00e9 (p\u0159edklinick\u00e9\/pilotn\u00ed)<\/strong><br>- Detoxikace, lymfatick\u00fd syst\u00e9m<br>- Dlouhodob\u00e9 p\u0159e\u017eit\u00ed p\u0159i rakovin\u011b<br>- 1 064 nm hlubok\u00e9 mozkov\u00e9 struktury<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Kontakt_zu_PBM-Anwendern_%E2%80%93_Arzte_Kliniken\"><\/span>Kontakt s u\u017eivateli PBM - l\u00e9ka\u0159i \/ kliniky<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Augenheilkunde_%E2%80%93_Trockene_AMD_Makuladegeneration\"><\/span>Oftalmologie - Such\u00e1 AMD (makul\u00e1rn\u00ed degenerace)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Jedn\u00e1 se o klinicky nejpokro\u010dilej\u0161\u00ed a regula\u010dn\u011b bezpe\u010dnou oblast. Za\u0159\u00edzen\u00ed&nbsp;<strong>Valeda (LumiThera)<\/strong>&nbsp;m\u00e1 certifik\u00e1t CE a od roku 2018 je schv\u00e1len v Evrop\u011b; od listopadu 2024 je schv\u00e1len FDA.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>Poskytovatel<\/th><th>M\u00edsto<\/th><th>Odkaz<\/th><\/tr><\/thead><tbody><tr><td><strong>Centrum pro makul\u00e1rn\u00ed s\u00edtnici<\/strong>&nbsp;(Prof. Dr. Hakan Kaymak - jeden z nejzku\u0161en\u011bj\u0161\u00edch u\u017eivatel\u016f na sv\u011bt\u011b, prov\u00e1d\u00ed ~10 % v\u0161ech z\u00e1krok\u016f PBM na sv\u011bt\u011b).<\/td><td>D\u00fcsseldorf<\/td><td><a href=\"https:\/\/augenchirurgie.clinic\/behandlungen\/photobiomodulation\" target=\"_blank\" rel=\"noopener\">oftalmochirurgie.clinic<\/a><\/td><\/tr><tr><td><strong>Oftalmolog Witten<\/strong>&nbsp;(Dr. Riha) - jedna z prvn\u00edch ordinac\u00ed v N\u011bmecku<\/td><td>Witten \/ NRW<\/td><td><a href=\"https:\/\/www.augenarzt-witten.de\/photobiomodulation\/\" target=\"_blank\" rel=\"noopener\">augenarzt-witten.de<\/a><\/td><\/tr><tr><td><strong>Oftalmolog Mnichov<\/strong>&nbsp;(Dr. Augsten)<\/td><td>Mnichov<\/td><td><a href=\"https:\/\/www.augenarzt-muc.de\/netzhaut\/behandlung\/valeda\/\" target=\"_blank\" rel=\"noopener\">oftalmolog-muc.de<\/a><\/td><\/tr><tr><td><strong>O\u010dn\u00ed l\u00e9ka\u0159i Gerl &amp; kolegov\u00e9<\/strong>&nbsp;(program Valeda)<\/td><td>Mnichov<\/td><td><a href=\"https:\/\/www.augenklinik.de\/behandlung\/valeda\" target=\"_blank\" rel=\"noopener\">eyeclinic.com<\/a><\/td><\/tr><tr><td><strong>Dr. Riha Oftalmologie<\/strong><\/td><td>V\u00edde\u0148 \/ AT<\/td><td><a href=\"https:\/\/dr-riha.com\/photobiomodulation\/\" target=\"_blank\" rel=\"noopener\">dr-riha.com<\/a><\/td><\/tr><tr><td><strong>O\u010dn\u00ed l\u00e9ka\u0159i Bern<\/strong>&nbsp;(CH)<\/td><td>Bern \/ CH<\/td><td><a href=\"https:\/\/www.augenaerzte-bern.ch\/leistungen\/photobiomodulation-bei-altersbedingter-makuladegeneration\/\" target=\"_blank\" rel=\"noopener\">oftalmologov\u00e9-bern.ch<\/a><\/td><\/tr><tr><td><strong>O\u010dn\u00ed klinika Bern<\/strong>&nbsp;(Prof. Garweg)<\/td><td>Bern \/ CH<\/td><td><a href=\"https:\/\/augenklinik-bern.ch\/fachpublikum\/amd-sprechstunde\/\" target=\"_blank\" rel=\"noopener\">eye-clinic-bern.ch<\/a><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Pozn\u00e1mka:<\/strong>\u00a0Tyto n\u00e1klady zpravidla nejsou hrazeny ze z\u00e1konn\u00e9ho zdravotn\u00edho poji\u0161t\u011bn\u00ed (IGeL).<br>LumiThera nab\u00edz\u00ed na sv\u00fdch webov\u00fdch str\u00e1nk\u00e1ch vyhled\u00e1va\u010d dal\u0161\u00edch center Valeda.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Onkologie_%E2%80%93_Orale_Mukositis_Chemo-Strahlentherapiefolge\"><\/span>Onkologie - Z\u00e1n\u011bt \u00fastn\u00ed sliznice (n\u00e1sledek chemoterapie\/radioterapie)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>PBM pro prevenci a l\u00e9\u010dbu z\u00e1n\u011btu \u00fastn\u00ed sliznice vych\u00e1z\u00ed z pokyn\u016f (MASCC\/ISOO) a je st\u00e1le \u010dast\u011bji za\u010dle\u0148ov\u00e1na do program\u016f onkologick\u00e9 podp\u016frn\u00e9 p\u00e9\u010de. V roce 2025\/2026 byl poprv\u00e9 vytvo\u0159en evropsk\u00fd klinick\u00fd pokyn.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>Poskytovatel<\/th><th>N\u00e1pov\u011bda<\/th><th>Odkaz<\/th><\/tr><\/thead><tbody><tr><td><strong>rj-laser.com<\/strong>&nbsp;- Platforma pro zubn\u00ed laserovou terapii s klinick\u00fdmi protokoly pro z\u00e1n\u011bt sliznic<\/td><td>Specializovan\u00fd port\u00e1l DE\/AT\/CH<\/td><td><a href=\"https:\/\/rj-laser.com\/de\/lasertherapie-mukositis-chemotherapieinduziert\" target=\"_blank\" rel=\"noopener\">rj-laser.com<\/a><\/td><\/tr><tr><td><strong>Informa\u010dn\u00ed slu\u017eba o rakovin\u011b (KID)<\/strong><\/td><td>D\u016frazn\u011b doporu\u010duje PBM jako mo\u017enost podp\u016frn\u00e9 l\u00e9\u010dby mukozitidy.<\/td><td><a href=\"https:\/\/www.krebsinformationsdienst.de\/fileadmin\/pdf-dateien\/informationsblaetter\/iblatt-mukositis-bei-krebs.pdf\" target=\"_blank\" rel=\"noopener\">krebsinformationsdienst.de<\/a><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Konkr\u00e9tn\u00ed kliniky v N\u011bmecku, kter\u00e9 b\u011b\u017en\u011b nab\u00edzej\u00ed PBM pro mukozitidu, to z\u0159\u00eddkakdy v\u00fdslovn\u011b zve\u0159ej\u0148uj\u00ed na webov\u00fdch str\u00e1nk\u00e1ch pro pacienty. L\u00e9\u010dba obvykle prob\u00edh\u00e1 jako sou\u010d\u00e1st stomatologick\u00e9 podp\u016frn\u00e9 p\u00e9\u010de ve velk\u00fdch onkologick\u00fdch centrech (nap\u0159. ve fakultn\u00edch nemocnic\u00edch).<br>Doporu\u010dujeme kontaktovat o\u0161et\u0159uj\u00edc\u00ed onkologick\u00e9 centrum nebo maxilofaci\u00e1ln\u00edho chirurga.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Dermatologie_%E2%80%93_Haut_Wundheilung_Akne_Psoriasis\"><\/span>Dermatologie - k\u016f\u017ee, hojen\u00ed ran, akn\u00e9, lup\u00e9nka<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>PBM s vyu\u017eit\u00edm sv\u011bteln\u00e9 terapie LED je zavedena v mnoha dermatologick\u00fdch ordinac\u00edch a estetick\u00fdch klinik\u00e1ch.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>Poskytovatel<\/th><th>M\u00edsto<\/th><th>Odkaz<\/th><\/tr><\/thead><tbody><tr><td><strong>Dermatologie Dr. Friedl<\/strong>&nbsp;- LED sv\u011bteln\u00e1 terapie (Medisol\u00ae) na akn\u00e9, vitiligo, lup\u00e9nku, st\u00e1rnut\u00ed k\u016f\u017ee, rakovinu b\u00edl\u00e9 k\u016f\u017ee (PDT)<\/td><td>Rakousko<\/td><td><a href=\"https:\/\/www.dermatologie-friedl.de\/leistungen\/aesthetische-medizin\/led-lichttherapie-mit-medisol-lampe\" target=\"_blank\" rel=\"noopener\">dermatology-friedl.com<\/a><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Krom\u011b toho mnoho estetick\u00fdch dermatologick\u00fdch ordinac\u00ed a laserov\u00fdch center v N\u011bmecku pou\u017e\u00edv\u00e1 PBM (nap\u0159. se syst\u00e9my Fotona). Doporu\u010dujeme vyhledat \u201edermatologie s LED sv\u011btelnou terapi\u00ed\u201c nebo \u201edermatolog s PBM\u201c s uveden\u00edm lokality.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Zahnmedizin_MKG-Chirurgie\"><\/span>Stomatologie \/ \u010delistn\u00ed chirurgie<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>PBM se \u0161iroce pou\u017e\u00edv\u00e1 ve stomatologii, nap\u0159. p\u0159i bolestech temporomandibul\u00e1rn\u00edho kloubu (CMD), poopera\u010dn\u00edm hojen\u00ed ran, implant\u00e1tech a z\u00e1n\u011btech sliznic. Ortodontist\u00e9 pou\u017e\u00edvaj\u00ed nap\u0159.&nbsp;<strong>P\u0159\u00edstroj OrthoPulse\u00ae<\/strong>&nbsp;k urychlen\u00ed pohybu zub\u016f (vlastn\u00ed aplikace, cca 600 \u20ac).<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>Poskytovatel \/ port\u00e1l<\/th><th>N\u00e1pov\u011bda<\/th><th>Odkaz<\/th><\/tr><\/thead><tbody><tr><td><strong>ZWP Online<\/strong>&nbsp;- P\u0159ehled KFO-PBM<\/td><td>Specializovan\u00fd port\u00e1l<\/td><td><a href=\"https:\/\/www.zwp-online.info\/zwpnews\/wirtschaft-und-recht\/recht\/photobiomodulation-in-der-kieferorthopadie\" target=\"_blank\" rel=\"noopener\">zwp-online.info<\/a><\/td><\/tr><tr><td><strong>Laserov\u00e9 syst\u00e9my Fotona<\/strong>&nbsp;(mo\u017enost vyhled\u00e1n\u00ed prodejce\/kliniky)<\/td><td>Zubn\u00ed a l\u00e9ka\u0159sk\u00e9 PBM, LightWalker<\/td><td><a href=\"https:\/\/www.fotona.com\/de\/treatments\/6496\/photobiomodulation-und-schmerzbehandlung\/\" target=\"_blank\" rel=\"noopener\">fotona.com<\/a><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Neurologie_Psychiatrie_%E2%80%93_Alzheimer_TBI_Depression_fruhe_Phase\"><\/span>Neurologie\/psychiatrie - Alzheimerova choroba, TBI, deprese (ran\u00e1 f\u00e1ze)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Tato oblast je st\u00e1le p\u0159edm\u011btem klinick\u00fdch zkou\u0161ek. Pravideln\u011b schv\u00e1len\u00e9 slu\u017eby pro pacienty jsou v N\u011bmecku st\u00e1le vz\u00e1cn\u00e9, nicm\u00e9n\u011b prvn\u00ed centra a studie ji\u017e existuj\u00ed.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>Poskytovatel \/ port\u00e1l<\/th><th>N\u00e1pov\u011bda<\/th><th>Odkaz<\/th><\/tr><\/thead><tbody><tr><td><strong>PBM-Photobiomodulation.eu<\/strong>&nbsp;- Evropsk\u00fd informa\u010dn\u00ed port\u00e1l s praktick\u00fdm p\u0159ehledem<\/td><td>Region DACH<\/td><td><a href=\"https:\/\/pbm-photobiomodulation.eu\/PBM\" target=\"_blank\" rel=\"noopener\">pbm-photobiomodulation.eu<\/a><\/td><\/tr><tr><td><strong>Neurofeedback Lucembursko<\/strong>&nbsp;- informuje o neurologick\u00fdch aplikac\u00edch PBM<\/td><td>LU\/DACH<\/td><td><a href=\"https:\/\/neurofeedback-luxembourg.com\/de\/photobiomodulation-ein-umfassender-leitfaden-fur-lichttherapievorteile\/\" target=\"_blank\" rel=\"noopener\">neurofeedback-luxembourg.com<\/a><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Allgemeine_Suchwerkzeuge\"><\/span>Obecn\u00e9 vyhled\u00e1vac\u00ed n\u00e1stroje<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>V\u00fdrobce LumiThera nab\u00edz\u00ed na sv\u00fdch webov\u00fdch str\u00e1nk\u00e1ch\u00a0<strong>Vyhled\u00e1v\u00e1n\u00ed polohy<\/strong>\u00a0pro praktiky spole\u010dnosti Valeda:\u00a0<a href=\"https:\/\/www.lumithera.com\/\" target=\"_blank\" rel=\"noopener\">lumithera.com<\/a><\/li>\n\n\n\n<li>Port\u00e1l\u00a0<strong>pbm-photobiomodulation.eu<\/strong>\u00a0uv\u00e1d\u00ed evropsk\u00e9 postupy<\/li>\n\n\n\n<li>Na str\u00e1nk\u00e1ch\u00a0<strong>Sv\u011btov\u00e1 asociace pro laserovou terapii (WALT)<\/strong>\u00a0nab\u00edz\u00ed glob\u00e1ln\u00ed vyhled\u00e1v\u00e1n\u00ed terapeut\u016f<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><strong>D\u016fle\u017eit\u00e9 upozorn\u011bn\u00ed:<\/strong>\u00a0\u00dahrada n\u00e1klad\u016f z prost\u0159edk\u016f povinn\u00e9ho zdravotn\u00edho poji\u0161t\u011bn\u00ed nen\u00ed v N\u011bmecku pro v\u011bt\u0161inu indikac\u00ed PBM dosud regulov\u00e1na (s v\u00fdjimkou podp\u016frn\u00e9 onkologie v n\u011bkter\u00fdch centrech).<br>PBM se pou\u017e\u00edv\u00e1 p\u0159ev\u00e1\u017en\u011b jako\u00a0<strong>Slu\u017eba IGeL<\/strong>\u00a0\u00fa\u010dtov\u00e1ny soukrom\u011b.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><em>Dokument je zalo\u017een na recenzovan\u00e9 literatu\u0159e z PubMed, PMC, Frontiers, MDPI, Springer a Nature v obdob\u00ed od 2019 do 02.2026. <\/em><br>Zobrazeno na <em>Parametry jsou p\u0159evzaty z klinick\u00fdch studi\u00ed a doporu\u010den\u00ed WALT\/MASCC.<\/em><\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>Ve\u0161ker\u00fd obsah byl sv\u011bdomit\u011b prozkoum\u00e1n a odr\u00e1\u017e\u00ed sou\u010dasn\u00fd (02.2026) publikovan\u00fd stav znalost\u00ed. M\u00e1 pouze informativn\u00ed charakter a nenahrazuje odbornou l\u00e9ka\u0159skou konzultaci.<br><br>Souvisej\u00edc\u00ed studie poskytuj\u00ed l\u00e9ka\u0159i dal\u0161\u00ed l\u00e9ka\u0159sk\u00e9 a v\u011bdeck\u00e9 informace.<\/p>\n<\/blockquote>","protected":false},"excerpt":{"rendered":"<p><span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Doba \u010dten\u00ed<\/span> <span class=\"rt-time\"> 12<\/span> <span class=\"rt-label rt-postfix\">minuty<\/span><\/span>Umfassende Studien\u00fcbersicht 2023\u20132025 Einleitung Photobiomodulation (PBM), auch bekannt als Low-Level-Lasertherapie (LLLT), ist eine nicht-invasive therapeutische Methode, die Licht bestimmter Wellenl\u00e4ngen nutzt, um biologische Prozesse in lebendem Gewebe zu stimulieren.Prim\u00e4rer Mechanismus ist die Absorption von Photonen durch den mitochondrialen Photoakzeptor Cytochrom-c-Oxidase (CCO), was die ATP-Synthese steigert, reaktive Sauerstoffspezies moduliert und eine Kaskade zellul\u00e4rer Regenerationsprozesse anst\u00f6\u00dft. Das&hellip;&nbsp;<a href=\"https:\/\/csiag.eu\/cs\/blog\/2026\/02\/18\/photobiomodulation-pbm\/\" rel=\"bookmark\">\u010c\u00edst d\u00e1le \"<span class=\"screen-reader-text\">Fotobiomodulace (PBM)<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-12784","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"modified_by":"Achim Goerner","_links":{"self":[{"href":"https:\/\/csiag.eu\/cs\/wp-json\/wp\/v2\/posts\/12784","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csiag.eu\/cs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csiag.eu\/cs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csiag.eu\/cs\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csiag.eu\/cs\/wp-json\/wp\/v2\/comments?post=12784"}],"version-history":[{"count":0,"href":"https:\/\/csiag.eu\/cs\/wp-json\/wp\/v2\/posts\/12784\/revisions"}],"wp:attachment":[{"href":"https:\/\/csiag.eu\/cs\/wp-json\/wp\/v2\/media?parent=12784"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csiag.eu\/cs\/wp-json\/wp\/v2\/categories?post=12784"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csiag.eu\/cs\/wp-json\/wp\/v2\/tags?post=12784"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}