{"id":10036,"date":"2025-06-02T19:05:44","date_gmt":"2025-06-02T19:05:44","guid":{"rendered":"https:\/\/csiag.eu\/?p=10036"},"modified":"2025-06-03T20:37:17","modified_gmt":"2025-06-03T20:37:17","slug":"%cf%84%ce%bf%ce%be%ce%b9%ce%ba%cf%8c%cf%84%ce%b7%cf%84%ce%b1-%cf%84%ce%bf%cf%85-lnp-%ce%b1%ce%bd%ce%ac%ce%bb%ce%bf%ce%b3%ce%b1-%ce%bc%ce%b5-%cf%84%ce%bf-%ce%bc%ce%ae%ce%ba%ce%bf%cf%82-%cf%84%ce%b7","status":"publish","type":"post","link":"https:\/\/csiag.eu\/el\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/","title":{"rendered":"\u03a4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd LNP \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03bc\u03ae\u03ba\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b1\u03c2 PEG"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_87_1 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 \u03c0\u03b5\u03c1\u03b9\u03b5\u03c7\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd<\/p>\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/csiag.eu\/el\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Welche_LNPs_wurden_verwendet\" >\u03a0\u03bf\u03b9\u03b1 LNP \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd;<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/csiag.eu\/el\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Toxizitat_wurde_nicht_durch_Studien_uberpruft\" >\u0397 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03c4\u03b5\u03af \u03b1\u03c0\u03cc \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/csiag.eu\/el\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Akkumulation_in_der_Leber\" >\u03a3\u03c5\u03c3\u03c3\u03ce\u03c1\u03b5\u03c5\u03c3\u03b7 \u03c3\u03c4\u03bf \u03ae\u03c0\u03b1\u03c1<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/csiag.eu\/el\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Der_Weg_in_die_Leber_und_die_Lange_der_Kette\" >\u0397 \u03b4\u03b9\u03b1\u03b4\u03c1\u03bf\u03bc\u03ae \u03c3\u03c4\u03bf \u03ae\u03c0\u03b1\u03c1 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03bc\u03ae\u03ba\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b1\u03c2<\/a><\/li><\/ul><\/nav><\/div>\n<span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">\u03a7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2<\/span> <span class=\"rt-time\"> 2<\/span> <span class=\"rt-label rt-postfix\">\u03bb\u03b5\u03c0\u03c4\u03ac<\/span><\/span>\n<p class=\"wp-block-paragraph\">\u038c\u03c3\u03bf \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b1 PEG (\u03c0\u03bf\u03bb\u03c5\u03b1\u03b9\u03b8\u03c5\u03bb\u03b5\u03bd\u03bf\u03b3\u03bb\u03c5\u03ba\u03cc\u03bb\u03b7), \u03c4\u03cc\u03c3\u03bf \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 LNP. \u0397 BioNTech \u03c4\u03bf \u03b5\u03be\u03b7\u03b3\u03b5\u03af \u03b1\u03c5\u03c4\u03cc \u03c3\u03c4\u03bf <a href=\"https:\/\/www.mdpi.com\/2227-9059\/9\/5\/530\" target=\"_blank\" rel=\"noreferrer noopener\">\u0394\u03b7\u03bc\u03bf\u03c3\u03af\u03b5\u03c5\u03c3\u03b7<\/a> \"Non-Immunotherapy Application of LNP-mRNA: Maximising Efficacy and Safety\" \u03b1\u03c0\u03cc 10.05.2021, \u03b1\u03bd \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c4\u03c5\u03c0\u03c9\u03bc\u03ad\u03bd\u03bf - \u03b5\u03bb\u03b1\u03c6\u03c1\u03ce\u03c2 - \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac: \"Maximising Efficacy\".<br>\u0397 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03cc\u03c4\u03b9 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03c4\u03c1\u03af\u03b1 \u03b9\u03bf\u03bd\u03c4\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03b1 \u03ba\u03b1\u03c4\u03b9\u03bf\u03bd\u03b9\u03ba\u03ac \u03bb\u03b9\u03c0\u03af\u03b4\u03b9\u03b1 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b2\u03b9\u03bf\u03b4\u03b9\u03b1\u03c3\u03c0\u03ce\u03bc\u03b5\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03b7 \u03b1\u03bd\u03b1\u03c0\u03cc\u03c6\u03b5\u03c5\u03ba\u03c4\u03b7 \u03c3\u03c5\u03c3\u03c3\u03ce\u03c1\u03b5\u03c5\u03c3\u03ae \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c4\u03bf\u03bd \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u03ad\u03c7\u03b5\u03b9 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c5\u03bd\u03ad\u03c0\u03b5\u03b9\u03b5\u03c2.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Welche_LNPs_wurden_verwendet\"><\/span>\u03a0\u03bf\u03b9\u03b1 LNP \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd;<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Pfizer<\/em> \/ <em>BioNTech<\/em> - BNT162b2 - <a href=\"https:\/\/www.echelon-inc.com\/product\/alc-0315\/\" target=\"_blank\" rel=\"noreferrer noopener\">ALC-0315<\/a> (\u03b9\u03bf\u03bd\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03bf) \u03ba\u03b1\u03b9 <a href=\"https:\/\/www.echelon-inc.com\/product\/alc-0159\/\" target=\"_blank\" rel=\"noreferrer noopener\">ALC-0159<\/a> (PEGylated)<br><em>Moderna<\/em> - <a href=\"https:\/\/www.echelon-inc.com\/product\/sm-102\/\" target=\"_blank\" rel=\"noreferrer noopener\">SM-102<\/a> (\u03b9\u03bf\u03bd\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03bf) \u03ba\u03b1\u03b9 <a href=\"https:\/\/www.echelon-inc.com\/product\/dmg-peg-2000\/\" target=\"_blank\" rel=\"noreferrer noopener\">PEG2000-DMG<\/a> (PEGylated)<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"562\" src=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-1024x562.png\" alt=\"\" class=\"wp-image-10045\" srcset=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-1024x562.png 1024w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-300x165.png 300w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-768x421.png 768w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-18x10.png 18w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image.png 1456w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u0393\u03b9\u03b1 \u03cc\u03bb\u03b1 \u03c4\u03b1 \u03bb\u03b9\u03c0\u03af\u03b4\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03bd\u03c9\u03c4\u03ad\u03c1\u03c9, \u03bf\u03b9 \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 (\u03c0.\u03c7. <a href=\"https:\/\/www.echelon-inc.com\/product\/alc-0315\/#tab-description\" target=\"_blank\" rel=\"noreferrer noopener\">Echelon Biosciences<\/a>) \"... \u03a0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd \u03c0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03af\u03bf\u03c5, \u03bc\u03cc\u03bd\u03bf \u03b3\u03b9\u03b1 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03c7\u03c1\u03ae\u03c3\u03b7\".<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Toxizitat_wurde_nicht_durch_Studien_uberpruft\"><\/span>\u0397 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03c4\u03b5\u03af \u03b1\u03c0\u03cc \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03bf <a href=\"https:\/\/www.tga.gov.au\/sites\/default\/files\/foi-2389-06.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">\u0394\u03b7\u03bc\u03bf\u03c3\u03af\u03b5\u03c5\u03c3\u03b7<\/a> \"Nonclinical Evaluation Report BNT 162b2 mRNA COVID-19 vaccine COMIRNATY\u2122\" \u03c4\u03b7\u03c2 \u0391\u03c5\u03c3\u03c4\u03c1\u03b1\u03bb\u03b9\u03b1\u03bd\u03ae\u03c2 \u039a\u03c5\u03b2\u03ad\u03c1\u03bd\u03b7\u03c3\u03b7\u03c2 - \u03a5\u03c0\u03bf\u03c5\u03c1\u03b3\u03b5\u03af\u03bf \u03a5\u03b3\u03b5\u03af\u03b1\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u0399\u03b1\u03bd\u03bf\u03c5\u03ac\u03c1\u03b9\u03bf \u03c4\u03bf\u03c5 2021 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b4\u03b9\u03b1\u03b2\u03ac\u03c3\u03b5\u03b9 \u03ba\u03b1\u03bd\u03b5\u03af\u03c2 \u03c3\u03c4\u03b7 \u03c3\u03b5\u03bb\u03af\u03b4\u03b1 11: \"\u0397 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03c3\u03ba\u03b5\u03c5\u03ac\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2 LNP \u03ae \u03c4\u03c9\u03bd \u03bd\u03ad\u03c9\u03bd \u03b5\u03ba\u03b4\u03cc\u03c7\u03c9\u03bd \u03b1\u03c0\u03cc \u03bc\u03cc\u03bd\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03b5\u03bd \u03bc\u03b5\u03bb\u03b5\u03c4\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac\".<br>\u039c\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03bb\u03cc\u03b3\u03b9\u03b1, \u03b4\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b9\u03b5\u03be\u03b1\u03c7\u03b8\u03b5\u03af \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03b5\u03c0\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03c9\u03bd \u03bd\u03ad\u03c9\u03bd \u03b5\u03ba\u03b4\u03cc\u03c7\u03c9\u03bd LNP \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b8\u03b7\u03ba\u03b1\u03bd \u03c0\u03b1\u03c1\u03b1\u03c0\u03ac\u03bd\u03c9.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Akkumulation_in_der_Leber\"><\/span>\u03a3\u03c5\u03c3\u03c3\u03ce\u03c1\u03b5\u03c5\u03c3\u03b7 \u03c3\u03c4\u03bf \u03ae\u03c0\u03b1\u03c1<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a0\u03bf\u03bb\u03bb\u03ac \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5\u03c1\u03b9\u03ba\u03ce\u03c2 \u03ae \u03c0\u03bb\u03ae\u03c1\u03c9\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf \u03ae\u03c0\u03b1\u03c1 \u03ba\u03b1\u03b9 \u03b5\u03b9\u03c3\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1 \u03c4\u03bf\u03c5 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2. \u03a4\u03bf \u03c0\u03c1\u03bf\u03b1\u03bd\u03b1\u03c6\u03b5\u03c1\u03b8\u03ad\u03bd \u03ad\u03ba\u03b4\u03bf\u03c7\u03bf ALC-315 \u03c3\u03c5\u03c3\u03c3\u03c9\u03c1\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c3\u03c4\u03bf \u03ae\u03c0\u03b1\u03c1, \u03cc\u03c0\u03c9\u03c2 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf <a href=\"https:\/\/www.judicialwatch.org\/wp-content\/uploads\/2022\/03\/JW-v-HHS-prod-3-02418.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">\u039c\u03b5\u03c1\u03b9\u03ba\u03ae \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c1\u03ce\u03c4\u03b7\u03c3\u03b7 \u03b1\u03c1\u03b9\u03b8. 2021-4379<\/a> \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03bd\u03cc\u03bc\u03bf \u03c0\u03b5\u03c1\u03af \u03b5\u03bb\u03b5\u03c5\u03b8\u03b5\u03c1\u03af\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7\u03c2 (FOIA), \u03bf \u03bf\u03c0\u03bf\u03af\u03bf\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03b1\u03bd\u03c4\u03b9\u03ba\u03b5\u03af\u03bc\u03b5\u03bd\u03bf \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c4\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1\u03c2 \u03c3\u03c4\u03b7\u03bd \u03c5\u03c0\u03cc\u03b8\u03b5\u03c3\u03b7 Judicial Watch, Inc. \u03ba\u03b1\u03c4\u03ac \u03a5\u03c0\u03bf\u03c5\u03c1\u03b3\u03b5\u03af\u03bf\u03c5 \u03a5\u03b3\u03b5\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u0391\u03bd\u03b8\u03c1\u03c9\u03c0\u03af\u03bd\u03c9\u03bd \u03a5\u03c0\u03b7\u03c1\u03b5\u03c3\u03b9\u03ce\u03bd \u03c4\u03c9\u03bd \u0397\u03a0\u0391 (21-cv-2418), \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03ba\u03ba\u03c1\u03b5\u03bc\u03b5\u03af \u03b5\u03c0\u03af \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c1\u03cc\u03bd\u03c4\u03bf\u03c2 \u03c3\u03c4\u03bf \u03a0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b5\u03b9\u03b1\u03ba\u03cc \u0394\u03b9\u03ba\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf \u03c4\u03c9\u03bd \u0397\u03a0\u0391 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03a0\u03b5\u03c1\u03b9\u03c6\u03ad\u03c1\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u039a\u03bf\u03bb\u03bf\u03cd\u03bc\u03c0\u03b9\u03b1, \u03c3\u03c4\u03b7 \u03c3\u03b5\u03bb\u03af\u03b4\u03b1 16 \u03b1\u03c0\u03cc 466:<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"542\" src=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-1024x542.png\" alt=\"\" class=\"wp-image-10054\" srcset=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-1024x542.png 1024w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-300x159.png 300w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-768x407.png 768w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-18x10.png 18w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3.png 1212w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u0391\u03bd\u03b1\u03c6\u03ad\u03c1\u03b5\u03c4\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b7 \u03c3\u03b5\u03bb\u03af\u03b4\u03b1 45 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03bf\u03b1\u03bd\u03b1\u03c6\u03b5\u03c1\u03b8\u03b5\u03af\u03c3\u03b1\u03c2 \u03ad\u03ba\u03b8\u03b5\u03c3\u03b7\u03c2. <a href=\"https:\/\/www.tga.gov.au\/sites\/default\/files\/foi-2389-06.pdf\" target=\"_blank\" rel=\"noopener\">\u0391\u03bd\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2<\/a>:<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"55\" src=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-1024x55.png\" alt=\"\" class=\"wp-image-10060\" srcset=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-1024x55.png 1024w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-300x16.png 300w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-768x42.png 768w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-18x1.png 18w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4.png 1218w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03c4\u03b7 \u03c3\u03b5\u03bb\u03af\u03b4\u03b1 46, \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03ac\u03c6\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03ba\u03b1\u03b8\u03b1\u03c1\u03ac \u03b8\u03b5\u03c9\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03c5\u03c0\u03bf\u03b8\u03b5\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae \u03bf\u03b4\u03cc\u03c2 \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c0\u03b5\u03b9\u03c1\u03ac\u03bc\u03b1\u03c4\u03b1 in vitro, \u03b1\u03bd \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03c5\u03c4\u03b5\u03af \u03c3\u03c4\u03bf\u03bd \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0395\u03bd\u03ce \u03c4\u03bf <a href=\"https:\/\/www.statnews.com\/2017\/01\/10\/moderna-trouble-mrna\/\" target=\"_blank\" rel=\"noreferrer noopener\">Moderna<\/a> \u03b4\u03b9\u03ad\u03ba\u03bf\u03c8\u03b5 \u03c4\u03b7\u03bd ALC-0315 \u03bb\u03cc\u03b3\u03c9 \u03b1\u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03bc\u03b5 \u03c4\u03bf \u03ae\u03c0\u03b1\u03c1 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03ad\u03c0\u03c4\u03c5\u03be\u03b5 \u03b7 \u03af\u03b4\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03bb\u03b1\u03c4\u03c6\u03cc\u03c1\u03bc\u03b1 SM (\u03b7 ALC-0315 \u03b5\u03af\u03c7\u03b5 \u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03c7\u03b8\u03b5\u03af \u03c0\u03bf\u03bb\u03cd \u03c4\u03bf\u03be\u03b9\u03ba\u03ae \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 Crigler-Najjar syndrome, \u03ad\u03c4\u03c3\u03b9 \u03ce\u03c3\u03c4\u03b5 \u03bf \u03c4\u03cc\u03c4\u03b5 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b5\u03c4\u03b1\u03af\u03c1\u03bf\u03c2 <em>Alexion<\/em> \u03c3\u03c4\u03b1\u03bc\u03ac\u03c4\u03b7\u03c3\u03b5 \u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b3\u03b9\u03b1 \u03bb\u03cc\u03b3\u03bf\u03c5\u03c2 \u03b1\u03c3\u03c6\u03b1\u03bb\u03b5\u03af\u03b1\u03c2), \u03b7 BioNTech \/ Pfizer \u03c3\u03c5\u03bd\u03b5\u03c7\u03af\u03b6\u03b5\u03b9 \u03bd\u03b1 \u03c4\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c0\u03b1\u03c1\u03ac \u03c4\u03b7\u03bd \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03ba\u03c1\u03af\u03c3\u03b7 \u03c4\u03b7\u03c2.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Der_Weg_in_die_Leber_und_die_Lange_der_Kette\"><\/span>\u0397 \u03b4\u03b9\u03b1\u03b4\u03c1\u03bf\u03bc\u03ae \u03c3\u03c4\u03bf \u03ae\u03c0\u03b1\u03c1 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03bc\u03ae\u03ba\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b1\u03c2<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">... \u03b8\u03b1 \u03c3\u03c5\u03bd\u03b5\u03c7\u03b9\u03c3\u03c4\u03b5\u03af ...<\/p>","protected":false},"excerpt":{"rendered":"<p><span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">\u03a7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2<\/span> <span class=\"rt-time\"> 2<\/span> <span class=\"rt-label rt-postfix\">\u03bb\u03b5\u03c0\u03c4\u03ac<\/span><\/span>\u038c\u03c3\u03bf \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b1 PEG (\u03c0\u03bf\u03bb\u03c5\u03b1\u03b9\u03b8\u03c5\u03bb\u03b5\u03bd\u03bf\u03b3\u03bb\u03c5\u03ba\u03cc\u03bb\u03b7), \u03c4\u03cc\u03c3\u03bf \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 LNP. \u0397 BioNTech \u03c4\u03bf \u03b5\u03be\u03b7\u03b3\u03b5\u03af \u03b1\u03c5\u03c4\u03cc \u03c3\u03c4\u03b7 \u03b4\u03b7\u03bc\u03bf\u03c3\u03af\u03b5\u03c5\u03c3\u03ae \u03c4\u03b7\u03c2 \"Non-Immunotherapy Application of LNP-mRNA: Maximising Efficacy and Safety\" \u03b1\u03c0\u03cc 10.05.2021, \u03b1\u03bd \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c4\u03c5\u03c0\u03c9\u03bc\u03ad\u03bd\u03b7 - \u03ba\u03ac\u03c0\u03c9\u03c2 - \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac: \"Maximising Efficacy\" \u0397 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03cc\u03c4\u03b9 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03c4\u03c1\u03af\u03b1 \u03b9\u03bf\u03bd\u03c4\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03b1 \u03ba\u03b1\u03c4\u03b9\u03bf\u03bd\u03b9\u03ba\u03ac \u03bb\u03b9\u03c0\u03af\u03b4\u03b9\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b7 \u03b2\u03b9\u03bf\u03b4\u03b9\u03b1\u03c3\u03c0\u03ce\u03bc\u03b5\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03b7 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03ac \u03c4\u03bf\u03c5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2...&nbsp;<a href=\"https:\/\/csiag.eu\/el\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/\" rel=\"bookmark\">\u03a0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \"<span class=\"screen-reader-text\">\u03a4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd LNP \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03bc\u03ae\u03ba\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b1\u03c2 PEG<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[628,316,1078],"tags":[5067,5066,5074,22,36,5080,5079,5069,5075,5071,4812,105,5073,5077,5070,5072,23,5076,5078,44],"class_list":["post-10036","post","type-post","status-publish","format-standard","hentry","category-corona","category-corona-blog","category-medizin","tag-alc-159","tag-alc-315","tag-alnylam","tag-biontech","tag-bnt162b2","tag-cholesterol","tag-dlin-mc3-dma","tag-dmg-peg2000","tag-elasomeran","tag-ionisierbar","tag-lnp","tag-moderna","tag-patisiran","tag-peg-lipid","tag-peg2000-dmg","tag-pegyliert","tag-pfizer","tag-phosholipid","tag-sterol","tag-tozinameran"],"modified_by":"Achim Goerner","_links":{"self":[{"href":"https:\/\/csiag.eu\/el\/wp-json\/wp\/v2\/posts\/10036","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csiag.eu\/el\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csiag.eu\/el\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csiag.eu\/el\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csiag.eu\/el\/wp-json\/wp\/v2\/comments?post=10036"}],"version-history":[{"count":0,"href":"https:\/\/csiag.eu\/el\/wp-json\/wp\/v2\/posts\/10036\/revisions"}],"wp:attachment":[{"href":"https:\/\/csiag.eu\/el\/wp-json\/wp\/v2\/media?parent=10036"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csiag.eu\/el\/wp-json\/wp\/v2\/categories?post=10036"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csiag.eu\/el\/wp-json\/wp\/v2\/tags?post=10036"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}