{"id":12268,"date":"2026-01-17T19:28:26","date_gmt":"2026-01-17T19:28:26","guid":{"rendered":"https:\/\/csiag.eu\/?p=12268"},"modified":"2026-04-13T15:35:04","modified_gmt":"2026-04-13T15:35:04","slug":"%ce%b8%ce%b5%cf%81%ce%b1%cf%80%ce%b5%ce%af%ce%b1-%cf%84%ce%b7%cf%82-%ce%b2%ce%bf%cf%81%cf%81%ce%b5%ce%bb%ce%af%cf%89%cf%83%ce%b7%cf%82-%ce%b3%ce%b9%ce%b1-%ce%b1%cf%83%ce%b8%ce%b5%ce%bd%ce%b5%ce%af","status":"publish","type":"post","link":"https:\/\/csiag.eu\/el\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/","title":{"rendered":"\u039d\u03cc\u03c3\u03bf\u03c2 \u03c4\u03bf\u03c5 Lyme - \u03a0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7 Huaier \u03b3\u03b9\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 ARLA (\u0391\u03bd\u03c4\u03b9\u03b2\u03b9\u03bf\u03c4\u03b9\u03ba\u03ac-\u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03b1\u03c1\u03b8\u03c1\u03af\u03c4\u03b9\u03b4\u03b1 Lyme)"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_87_1 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 \u03c0\u03b5\u03c1\u03b9\u03b5\u03c7\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd<\/p>\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#Pathogenese\" >\u03a0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#Herkommliche_Therapieformen\" >\u03a3\u03c5\u03bc\u03b2\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ad\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#NSAR\" >NSAIDS<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#DMARD\" >DMARD<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#Beispiel_ARLA-Patient_%E2%80%93_NSARs_und_DMARD\" >\u03a0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2 ARLA - \u039c\u03a3\u0391\u03a6 \u03ba\u03b1\u03b9 DMARDs<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#Biologika\" >\u0392\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#Huaier-Pilz_%E2%80%93_eine_Alternative\" >\u039c\u03b1\u03bd\u03b9\u03c4\u03ac\u03c1\u03b9 Huaier - \u03bc\u03b9\u03b1 \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03bb\u03cd\u03c3\u03b7;<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#NF-%CE%BAB-Pathway-Hemmung_Plasma-Membran-Signalisierung\" >\u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03bf\u03c5 \u03bc\u03bf\u03bd\u03bf\u03c0\u03b1\u03c4\u03b9\u03bf\u03cd NF-\u03ba\u0392 (\u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7 \u03bc\u03ad\u03c3\u03c9 \u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03bd\u03b7\u03c2)<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#JAKSTAT-Pathway-Modulation_Endosomal-Signalisierung_IL-6-Feedback\" >\u0394\u03b9\u03b1\u03bc\u03cc\u03c1\u03c6\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bf\u03b4\u03bf\u03cd JAK\/STAT (\u03b5\u03bd\u03b4\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7 + \u03b1\u03bd\u03b1\u03c4\u03c1\u03bf\u03c6\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7 IL-6)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#Vergleich_JAK1i_wie_Upadacitinib_vs_Huaier\" >\u03a3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7: JAK1i (\u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf upadacitinib) \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03bf\u03c5 Huaier:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#PI3KAKT-Aktivierung_Mitochondriale_Restoration_Treg-Support\" >\u0395\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 PI3K\/AKT (\u03bc\u03b9\u03c4\u03bf\u03c7\u03bf\u03bd\u03b4\u03c1\u03b9\u03b1\u03ba\u03ae \u03b1\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 + \u03c5\u03c0\u03bf\u03c3\u03c4\u03ae\u03c1\u03b9\u03be\u03b7 Treg)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#Spezifische_Effekte_bei_ARLA\" >\u03a3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd ARLA:<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#Ribosomale_Homoostase_Tanaka-Hauptfund\" >\u039f\u03bc\u03bf\u03b9\u03cc\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c1\u03b9\u03b2\u03bf\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd (\u03ba\u03cd\u03c1\u03b9\u03bf \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1 Tanaka)<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#Mechanistischer_Vergleich_Huaier_zu_Biologika\" >\u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 Huaier \u03bc\u03b5 \u03c4\u03b1 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#Dosierungsempfehlung_bei_ARLA_im_fortgeschrittenen_Stadium\" >Dosierungsempfehlung bei ARLA im fortgeschrittenen Stadium<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#Vorschlag_fur_ARLA-Dosierung\" >\u03a0\u03c1\u03cc\u03c4\u03b1\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 ARLA<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#Weitere_relevante_Beitrage_zum_Anwendungsbereich_des_Huaier-Pilzes\" >\u0386\u03bb\u03bb\u03b1 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03ac\u03c1\u03b8\u03c1\u03b1 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03bf \u03c0\u03b5\u03b4\u03af\u03bf \u03b5\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae\u03c2 \u03c4\u03bf\u03c5 \u03bc\u03b1\u03bd\u03b9\u03c4\u03b1\u03c1\u03b9\u03bf\u03cd Huaier<\/a><\/li><\/ul><\/nav><\/div>\n<span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">\u03a7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2<\/span> <span class=\"rt-time\"> 18<\/span> <span class=\"rt-label rt-postfix\">\u03bb\u03b5\u03c0\u03c4\u03ac<\/span><\/span>\n<p class=\"wp-block-paragraph\">\u0397 \u03bd\u03cc\u03c3\u03bf\u03c2 \u03c4\u03bf\u03c5 Lyme \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc <em>Borrelia burgdorferi<\/em>, \u03ad\u03bd\u03b1 \u03c3\u03c0\u03b5\u03b9\u03c1\u03bf\u03b5\u03b9\u03b4\u03ad\u03c2 \u03b2\u03b1\u03ba\u03c4\u03ae\u03c1\u03b9\u03bf \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 <em>\u0392\u03bf\u03c1\u03c1\u03b5\u03bb\u03af\u03c9\u03c3\u03b7 Lyme <\/em>(\u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae \u03c9\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c2 \u03c4\u03bf\u03c5 Lyme).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0395\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03bb\u03af\u03b3\u03b1 \u03c0\u03b1\u03b8\u03bf\u03b3\u03cc\u03bd\u03b1 \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03cc\u03c3\u03bf \u03c3\u03c5\u03bd\u03b1\u03c1\u03c0\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03cc \u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03ac\u03c0\u03bf\u03c8\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03c4\u03b9\u03c2 \u03c0\u03b9\u03bf \u03b4\u03cd\u03c3\u03ba\u03bf\u03bb\u03b5\u03c2 \u03b2\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ad\u03c2 \u03bb\u03bf\u03b9\u03bc\u03ce\u03be\u03b5\u03b9\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u0391\u03c3\u03c5\u03bd\u03ae\u03b8\u03b9\u03c3\u03c4\u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae:<\/strong> \u0393\u03c1\u03b1\u03bc\u03bc\u03b9\u03ba\u03cc \u03c7\u03c1\u03c9\u03bc\u03cc\u03c3\u03c9\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd\u03c0\u03bb\u03bf\u03ba\u03bf \u03c0\u03bb\u03b1\u03c3\u03bc\u03b9\u03b4\u03b9\u03b1\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1<\/li>\n\n\n\n<li><strong>\u0394\u03ac\u03c3\u03ba\u03b1\u03bb\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b5\u03b9\u03c3\u03b2\u03bf\u03bb\u03ae\u03c2:<\/strong> \u0391\u03bd\u03c4\u03b9\u03b3\u03bf\u03bd\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ae VlsE, \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2, \u03b2\u03b9\u03bf\u03c6\u03af\u03bb\u03bc<\/li>\n\n\n\n<li><strong>\u03a0\u03b1\u03b8\u03bf\u03b3\u03cc\u03bd\u03b1 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ce\u03bd \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03bd:<\/strong> \u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03b5\u03b9 \u03c3\u03c7\u03b5\u03b4\u03cc\u03bd \u03cc\u03bb\u03b1 \u03c4\u03b1 \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1 \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03bd<\/li>\n\n\n\n<li><strong>\u0395\u03b9\u03b4\u03b9\u03ba\u03cc\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03bc\u03bf\u03bd\u03ae:<\/strong> \u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03b5\u03b9 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b5\u03c2 \u03bb\u03bf\u03b9\u03bc\u03ce\u03be\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b1\u03c1\u03ba\u03bf\u03cd\u03bd \u03b3\u03b9\u03b1 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1<\/li>\n\n\n\n<li><strong>\u039a\u03c5\u03c1\u03b9\u03b1\u03c1\u03c7\u03af\u03b1 \u03c4\u03bf\u03c5 TLR2:<\/strong> \u03a0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03bc\u03b1\u03b6\u03b9\u03ba\u03ae \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae (\u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 4 \u03c4\u03cd\u03c0\u03bf\u03c5 Toll)<\/li>\n\n\n\n<li><strong>\u0391\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03bf \u03b4\u03c5\u03bd\u03b1\u03bc\u03b9\u03ba\u03cc:<\/strong> \u039f\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bf\u03b9\u03bc\u03ce\u03b4\u03b7 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1 (ARLA)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf\u03b9 \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf\u03b9 \u03bc\u03b5 \u03b1\u03c1\u03b8\u03c1\u03af\u03c4\u03b9\u03b4\u03b1 Lyme \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03b1\u03bd\u03c4\u03b9\u03b2\u03b9\u03bf\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 10% \u03b4\u03b5\u03bd \u03b1\u03bd\u03c4\u03b1\u03c0\u03bf\u03ba\u03c1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c0\u03c4\u03cd\u03c3\u03c3\u03bf\u03c5\u03bd \u03b1\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b3\u03bd\u03c9\u03c3\u03c4\u03cc \u03c9\u03c2 \u03b1\u03c1\u03b8\u03c1\u03af\u03c4\u03b9\u03b4\u03b1 Lyme. <strong>\u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03c3\u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03b2\u03b9\u03bf\u03c4\u03b9\u03ba\u03ac \u03b1\u03c1\u03b8\u03c1\u03af\u03c4\u03b9\u03b4\u03b1 Lyme<\/strong> (<em>ARLA<\/em>).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0391\u03c5\u03c4\u03ac \u03c4\u03b1 10% \u03c7\u03c9\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>50% \u03bc\u03b5 \u03b1\u03c5\u03b8\u03cc\u03c1\u03bc\u03b7\u03c4\u03b7 \u03cd\u03c6\u03b5\u03c3\u03b7 (\u03c0\u03c1\u03bf\u03c3\u03c9\u03c1\u03b9\u03bd\u03ae \u03ae \u03bc\u03cc\u03bd\u03b9\u03bc\u03b7 \u03cd\u03c6\u03b5\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5) \u03c3\u03b5 x \u03ad\u03c4\u03b7<\/li>\n\n\n\n<li>30% \u03c0\u03c1\u03bf\u03c2 <strong>DMARD<\/strong> (\u0391\u03bd\u03c4\u03b9\u03c1\u03b5\u03c5\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03c0\u03bf\u03c5 \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03c4\u03b7 \u03bd\u03cc\u03c3\u03bf) \/ <strong>\u0392\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac<\/strong> (<strong>\u03b4\u03c1\u03bf\u03c5\u03bd \u03ba\u03b1\u03c4\u03ac \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03c9\u03bd \u03b4\u03bf\u03bc\u03ce\u03bd-\u03c3\u03c4\u03cc\u03c7\u03c9\u03bd<\/strong> \u03c4\u03bf\u03c5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2)<\/li>\n\n\n\n<li>20% \u03c7\u03c1\u03cc\u03bd\u03b9\u03bf \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u0391\u03c1\u03c7\u03b9\u03ba\u03ac, \u03b5\u03be\u03b7\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b7 \u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 (\u03b1\u03b9\u03c4\u03af\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5), \u03bf\u03b9 \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b1 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03c5 \u03bc\u03cd\u03ba\u03b7\u03c4\u03b1 Huaier.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Pathogenese\"><\/span>\u03a0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0386\u03bc\u03b5\u03c3\u03b7 \u03b5\u03b9\u03c3\u03b2\u03bf\u03bb\u03ae:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0394\u03ad\u03c3\u03bc\u03b5\u03c5\u03c3\u03b7 \u03ba\u03bf\u03bb\u03bb\u03b1\u03b3\u03cc\u03bd\u03bf\u03c5\/\u03b4\u03b5\u03ba\u03bf\u03c1\u03af\u03bd\u03b7\u03c2 \u03bc\u03ad\u03c3\u03c9 DbpA\/B - (\u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c3\u03c4\u03bf \u03c0\u03b1\u03b8\u03bf\u03b3\u03cc\u03bd\u03bf \u03bd\u03b1 \u03c0\u03c1\u03bf\u03c3\u03ba\u03bf\u03bb\u03bb\u03ac\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b4\u03bf\u03bc\u03ad\u03c2 \u03c0\u03bb\u03bf\u03cd\u03c3\u03b9\u03b5\u03c2 \u03c3\u03b5 \u03ba\u03bf\u03bb\u03bb\u03b1\u03b3\u03cc\u03bd\u03bf, \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b5\u03b9\u03c3\u03b2\u03bf\u03bb\u03ae \u03c3\u03c4\u03bf\u03bd \u03be\u03b5\u03bd\u03b9\u03c3\u03c4\u03ae \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd \u03b1\u03c0\u03bf\u03b9\u03ba\u03b9\u03c3\u03bc\u03cc \u03c4\u03bf\u03c5 \u03c0\u03b1\u03b8\u03bf\u03b3\u03cc\u03bd\u03bf\u03c5 \u03c3\u03c4\u03bf\u03bd \u03be\u03b5\u03bd\u03b9\u03c3\u03c4\u03ae).<\/li>\n\n\n\n<li>\u0394\u03ad\u03c3\u03bc\u03b5\u03c5\u03c3\u03b7 \u03b9\u03bd\u03c9\u03b4\u03bf\u03bd\u03b5\u03ba\u03c4\u03af\u03bd\u03b7\u03c2 \u03bc\u03ad\u03c3\u03c9 BBK32 - (\u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03c5\u03bd\u03b1\u03bc\u03b9\u03ba\u03ae \u03b5\u03bd\u03af\u03c3\u03c7\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03b4\u03ad\u03c3\u03bc\u03b5\u03c5\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03b1\u03b8\u03bf\u03b3\u03cc\u03bd\u03bf\u03c5 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03bf\u03c5 \u03c3\u03c7\u03b7\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03bf\u03cd \u03c0\u03bf\u03bb\u03c5\u03bc\u03b5\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b9\u03bd\u03c9\u03b4\u03bf\u03bd\u03b5\u03ba\u03c4\u03af\u03bd\u03b7\u03c2 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03ba\u03cc \u03c6\u03bf\u03c1\u03c4\u03af\u03bf (\u03c0.\u03c7. \u03c3\u03c4\u03b7\u03bd \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1 \u03c4\u03bf\u03c5 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2): \u03cc\u03c3\u03bf \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7, \u03c4\u03cc\u03c3\u03bf \u03b9\u03c3\u03c7\u03c5\u03c1\u03cc\u03c4\u03b5\u03c1\u03b7). <\/li>\n\n\n\n<li>\u0388\u03bc\u03bc\u03b5\u03c3\u03b7 \u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b2\u03bb\u03ac\u03b2\u03b7 \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03c0\u03c5\u03c1\u03bf\u03b4\u03bf\u03c4\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0395\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 (\u03ba\u03c5\u03c1\u03af\u03b1\u03c1\u03c7\u03bf\u03c2 TLR2):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u0395\u03c0\u03b9\u03c6\u03b1\u03bd\u03b5\u03b9\u03b1\u03ba\u03ad\u03c2 \u03bb\u03b9\u03c0\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 (OspA, OspC, OspE)<\/strong> \u2192 \u0395\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 TLR2\/6 (\u03c0\u03c1\u03ce\u03b9\u03bc\u03b7 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03bf\u03c5\u03bd \u03c5\u03c0\u03b5\u03c1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ad\u03c2 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b5\u03b9\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2)<\/li>\n\n\n\n<li><strong>\u03a0\u03b5\u03c0\u03c4\u03b9\u03b4\u03bf\u03b3\u03bb\u03c5\u03ba\u03ac\u03bd\u03b5\u03c2<\/strong> \u2192 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 TLR2 (\u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7 \u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ad\u03bc\u03c6\u03c5\u03c4\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03c3\u03c4\u03b9\u03ba\u03bf\u03cd \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2)<\/li>\n\n\n\n<li>\u039f\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03bc\u03b1\u03b6\u03b9\u03ba\u03ae <strong>\u0395\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 NF-\u03ba\u0392\/MAPK<\/strong> (\u03ad\u03c7\u03b5\u03b9 \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03ad\u03bd\u03c4\u03bf\u03bd\u03b7 \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03ad\u03c1\u03c9\u03c3\u03b7&nbsp;<strong>\u03c0\u03c1\u03bf\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b5\u03b9\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03af\u03bd\u03b5\u03c2<\/strong>&nbsp;\u03cc\u03c0\u03c9\u03c2 <strong>TNF-\u03b1, IL-6 \u03ba\u03b1\u03b9 IL-1\u03b2<\/strong>, \u03c0\u03bf\u03c5 \u03b5\u03bd\u03c4\u03b5\u03af\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7 \u03b1\u03bd\u03c4\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03bd\u03cc\u03c3\u03bf Lyme)<\/li>\n\n\n\n<li>\u039c\u03b1\u03b6\u03b9\u03ba\u03ae <strong>\u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c0\u03c1\u03bf\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03c9\u03b4\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd<\/strong><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0391\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03b9\u03c3\u03b2\u03bf\u03bb\u03ae:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2<\/strong><br><em>OspE, OspF<\/em> - \u039f\u03b9 \u03b5\u03c0\u03b9\u03c6\u03b1\u03bd\u03b5\u03b9\u03b1\u03ba\u03ad\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03b2\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c3\u03b4\u03ad\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 H \u03c4\u03bf\u03c5 \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03b6\u03bf\u03c5\u03bd \u03ad\u03c4\u03c3\u03b9 \u03c4\u03b7\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2, \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03b8\u03b1 \u03ba\u03b1\u03c4\u03ad\u03c3\u03c4\u03c1\u03b5\u03c6\u03b5 \u03c4\u03bf \u03b2\u03b1\u03ba\u03c4\u03ae\u03c1\u03b9\u03bf.<br>\u039f OspF \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c0\u03b1\u03af\u03b6\u03b5\u03b9 \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03b7\u03bd \u03b1\u03c5\u03c4\u03bf\u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c3\u03af\u03b1 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03bf\u03c5 \u03b4\u03b9\u03ba\u03bf\u03cd \u03c4\u03bf\u03c5 \u03c0\u03b1\u03b8\u03bf\u03b3\u03cc\u03bd\u03bf\u03c5 \u03c3\u03c4\u03b1 \u03c4\u03c3\u03b9\u03bc\u03c0\u03bf\u03cd\u03c1\u03b9\u03b1: \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03bc\u03b5 OspF \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03c3\u03b1\u03bd \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c3\u03c0\u03b5\u03b9\u03c1\u03bf\u03c7\u03b1\u03af\u03c4\u03c9\u03bd \u03ad\u03c9\u03c2 \u03ba\u03b1\u03b9 90%. \u03a0\u03b7\u03b3\u03ae:<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC186469\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u039c\u03b5\u03c1\u03b9\u03ba\u03ae \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae \u03c4\u03b7\u03c2 Borrelia burgdorferi \u03b5\u03bd\u03c4\u03cc\u03c2 \u03c4\u03c9\u03bd \u03ba\u03c1\u03bf\u03c4\u03ce\u03bd\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c3\u03ba\u03bf\u03bb\u03bb\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03c3\u03b5 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b1 \u03bc\u03b5 OspE \u03ae OspF<\/a>)<\/li>\n\n\n\n<li><strong>\u0391\u03bd\u03c4\u03b9\u03b3\u03bf\u03bd\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ae<\/strong><br><em>VlsE - \u03bc\u03b5\u03c4\u03b1\u03b2\u03bb\u03b7\u03c4\u03ae \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b9\u03ba\u03ae \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03c5\u03c7\u03af\u03b1 \u03c0\u03bf\u03c5 \u03bc\u03bf\u03b9\u03ac\u03b6\u03b5\u03b9 \u03bc\u03b5 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u0395\u03ba\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9<\/em> &#8211; verhindert Erkennung durch das Immunsystem<\/li>\n\n\n\n<li><strong>\u03a3\u03c7\u03b7\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b2\u03b9\u03bf\u03c6\u03af\u03bb\u03bc<\/strong><br>selbst produzierte <em>\u03b5\u03be\u03c9\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03c0\u03bf\u03bb\u03c5\u03bc\u03b5\u03c1\u03ae\u03c2 \u03bf\u03c5\u03c3\u03af\u03b1<\/em> zum Eigenschutz des Erregers<\/li>\n\n\n\n<li><strong>\u0395\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b5\u03bc\u03bc\u03bf\u03bd\u03ae<\/strong><br>in Spiroch\u00e4ten-Form-Varianten (Gruppe gramnegativer, schraubenf\u00f6rmiger, anaerob oder fakultativ anaerob lebender Bakterien, u.a. auch Syphilis- und Leptospirose-Erreger) m\u00f6glich, verstecken sich innerhalb der infizierten Zelle und k\u00f6nnen dort symptomlos \u00fcber Monate und Jahre verweilen<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0391\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1 (\u03bc\u03b5\u03c4\u03b1-\u03bc\u03bf\u03bb\u03c5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u0394\u03b9\u03b1\u03c3\u03c4\u03b1\u03c5\u03c1\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd OspA \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03c9\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd (\u03c0.\u03c7. LFA-1)<\/strong><br>molekulares Mimicry: f\u00fchrt zu einer&nbsp;autoimmunologisch aufrechterhaltenen Entz\u00fcndung, auch wenn der Erreger bereits eliminiert ist.<br>\u0397 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03a4-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03b5 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ac \u03c0\u03c1\u03bf\u03b4\u03b9\u03b1\u03c4\u03b5\u03b8\u03b5\u03b9\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c5\u03c0\u03b5\u03c1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c0\u03c1\u03bf\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03c9\u03b4\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd (\u03c0.\u03c7.&nbsp;<strong>TNF\u03b1, IFN\u03b3<\/strong>) verbunden, die den Entz\u00fcndungsprozess aufrecht erh\u00e4lt<\/li>\n\n\n\n<li><strong>\u0394\u03b9\u03ac\u03b4\u03bf\u03c3\u03b7 \u03b5\u03c0\u03b9\u03c4\u03cc\u03c0\u03c9\u03bd<\/strong><br>Nach anf\u00e4nglicher Immunreaktion gegen Borrelien-Antigene wie&nbsp;<strong>OspA<\/strong>&nbsp;\u03b7 \u03b5\u03c0\u03af\u03bc\u03bf\u03bd\u03b7 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03b1\u03c0\u03bf\u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b9\u03c3\u03c4\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03ad\u03c1\u03c9\u03c3\u03b7 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u03c4\u03bf\u03c5 \u03af\u03b4\u03b9\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd.<br>\u03a3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1, \u03b1\u03c5\u03c4\u03ad\u03c2 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1, \u03bf\u03c0\u03cc\u03c4\u03b5 \u03b7 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7 \u03b5\u03c0\u03b5\u03ba\u03c4\u03b5\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bd\u03ad\u03bf\u03c5\u03c2, \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac \u03be\u03ad\u03bd\u03bf\u03c5\u03c2, \u03b1\u03bd\u03b5\u03be\u03ac\u03c1\u03c4\u03b7\u03c4\u03bf\u03c5\u03c2 \u03b1\u03c0\u03cc \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03b1 \u03b5\u03c0\u03b9\u03c4\u03cc\u03c0\u03bf\u03c5\u03c2. \u0397 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03b1\u03c5\u03c4\u03ae \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ad\u03bb\u03bb\u03b5\u03b9\u03c8\u03b7 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd&nbsp;<strong>IL-10<\/strong>&nbsp;verst\u00e4rkt, was zu einer unkontrollierten Autoimmunit\u00e4t f\u00fchren kann.<\/li>\n\n\n\n<li><strong>\u039f\u03b9 \u03b5\u03c0\u03af\u03bc\u03bf\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03bf\u03b3\u03bb\u03c5\u03ba\u03ac\u03bd\u03b5\u03c2 \u03c0\u03c5\u03c1\u03bf\u03b4\u03bf\u03c4\u03bf\u03cd\u03bd \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03a4<\/strong><br>Bestandteile der bakteriellen Zellwand des Erregers k\u00f6nnen, auch nach erfolgreicher Antibiotikatherapie, in Geweben wie Leber oder in Gelenken vereilen und stimulieren weiterhin das Immunsystem. Zudem beeinflussen sie den&nbsp;Energiestoffwechsel von Immunzellen&nbsp;und f\u00f6rdern die Produktion entz\u00fcndungsf\u00f6rdernder Proteine, was wiederum die Autoimmunit\u00e4t verst\u00e4rkt<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Herkommliche_Therapieformen\"><\/span>\u03a3\u03c5\u03bc\u03b2\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ad\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"NSAR\"><\/span>NSAIDS<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03b1 \u03bc\u03b7 \u03c3\u03c4\u03b5\u03c1\u03bf\u03b5\u03b9\u03b4\u03ae \u03b1\u03bd\u03c4\u03b9\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 (\u039c\u03a3\u0391\u03a6) \u03b5\u03af\u03bd\u03b1\u03b9 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03c0\u03bf\u03c5 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae, \u03b1\u03bd\u03b1\u03ba\u03bf\u03c5\u03c6\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03c0\u03cc\u03bd\u03bf \u03ba\u03b1\u03b9 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03c0\u03c5\u03c1\u03b5\u03c4\u03cc, \u03b1\u03bb\u03bb\u03ac, \u03c3\u03b5 \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b1 \u03ba\u03bf\u03c1\u03c4\u03b9\u03ba\u03bf\u03c3\u03c4\u03b5\u03c1\u03bf\u03b5\u03b9\u03b4\u03ae, \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c4\u03b5\u03c1\u03bf\u03b5\u03b9\u03b4\u03ae.<br>\u03a3\u03b5 \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b1 \u03c3\u03c4\u03b5\u03c1\u03bf\u03b5\u03b9\u03b4\u03ae, \u03c4\u03b1 \u039c\u03a3\u0391\u03a6 \u03b4\u03b5\u03bd \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03bc\u03cc\u03bb\u03c5\u03bd\u03c3\u03b7\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0391\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bd \u03bc\u03b7 \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ac \u03c4\u03b1 \u03ad\u03bd\u03b6\u03c5\u03bc\u03b1 COX (\u03ba\u03c5\u03ba\u03bb\u03bf\u03bf\u03be\u03c5\u03b3\u03b5\u03bd\u03ac\u03c3\u03b7)-1 \u03ba\u03b1\u03b9 COX-2 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03c5\u03bd \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03b3\u03bb\u03b1\u03bd\u03b4\u03af\u03bd\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03be\u03ac\u03bd\u03b7.<br>\u0395\u03bd\u03ce \u03b7 COX-1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03ae (\u03b1\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03b5\u03bd\u03b5\u03c1\u03b3\u03ae \u03ae \u03b1\u03bd\u03b1\u03c3\u03c4\u03b1\u03bb\u03b5\u03af, \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03c0.\u03c7. \u03ad\u03bb\u03ba\u03bf\u03c2 \u03c3\u03c4\u03bf\u03bc\u03ac\u03c7\u03bf\u03c5, \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ac \u03c0\u03c1\u03bf\u03b2\u03bb\u03ae\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03ac\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03b1\u03b9\u03bc\u03bf\u03c1\u03c1\u03b1\u03b3\u03af\u03b1), \u03b7 COX-2 \u03c1\u03c5\u03b8\u03bc\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae\u03c2.<br>\u039f \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c4\u03b7\u03c2 COX-2 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03c4\u03b1 \u03b5\u03c0\u03b9\u03b8\u03c5\u03bc\u03b7\u03c4\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1, \u03c0.\u03c7. \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u03c0\u03cc\u03bd\u03bf\u03c5, \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c0\u03c5\u03c1\u03b5\u03c4\u03bf\u03cd.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0394\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03bf\u03c5 \u03cc\u03c4\u03b9 \u03c4\u03b1 \u03bc\u03b7 \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ac \u039c\u03a3\u0391\u03a6 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bd \u03b5\u03be\u03af\u03c3\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b4\u03cd\u03bf \u03ad\u03bd\u03b6\u03c5\u03bc\u03b1, \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c4\u03b9\u03c2 \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2 (\u03c0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2) \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b8\u03b7\u03ba\u03b1\u03bd \u03c0\u03b1\u03c1\u03b1\u03c0\u03ac\u03bd\u03c9.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a4\u03b1 \u039c\u03a3\u0391\u03a6 \u03ad\u03c7\u03bf\u03c5\u03bd \u03bc\u03cc\u03bd\u03bf \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7<\/strong>. \u03a4\u03bf \u03c0\u03b1\u03b8\u03bf\u03b3\u03cc\u03bd\u03bf \u03b5\u03be\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b1\u03c1\u03cc\u03bd \u03ba\u03b1\u03b9 \u03b5\u03bd\u03b5\u03c1\u03b3\u03cc, \u03bf\u03b9 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b5\u03b9\u03c2 \u03bc\u03b5\u03c3\u03bf\u03bb\u03b1\u03b2\u03b7\u03c4\u03ad\u03c2 (\u03c0\u03c1\u03bf\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b5\u03b9\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03af\u03bd\u03b5\u03c2) \u03c3\u03c5\u03bd\u03b5\u03c7\u03af\u03b6\u03bf\u03c5\u03bd \u03bd\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03bd\u03b5\u03bc\u03c0\u03cc\u03b4\u03b9\u03c3\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b7 \u03b4\u03b9\u03ac\u03b2\u03c1\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c7\u03cc\u03bd\u03b4\u03c1\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b5\u03c7\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03bc\u03b5\u03af\u03c9\u03c4\u03b7.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03b1 \u03c0\u03b9\u03bf \u03ba\u03bf\u03b9\u03bd\u03ac \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ac \u03c4\u03c9\u03bd \u03bc\u03b7 \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ce\u03bd \u039c\u03a3\u0391\u03a6 \u03b5\u03af\u03bd\u03b1\u03b9<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0391\u03ba\u03b5\u03c4\u03c5\u03bb\u03bf\u03c3\u03b1\u03bb\u03b9\u03ba\u03c5\u03bb\u03b9\u03ba\u03cc \u03bf\u03be\u03cd<\/li>\n\n\n\n<li>\u0394\u03b9\u03ba\u03bb\u03bf\u03c6\u03b5\u03bd\u03ac\u03ba\u03b7<\/li>\n\n\n\n<li>\u0399\u03b2\u03bf\u03c5\u03c0\u03c1\u03bf\u03c6\u03b1\u03af\u03bd\u03b7<\/li>\n\n\n\n<li>\u0399\u03bd\u03b4\u03bf\u03bc\u03b5\u03b8\u03b1\u03ba\u03af\u03bd\u03b7<\/li>\n\n\n\n<li>\u039a\u03b5\u03c4\u03bf\u03c0\u03c1\u03bf\u03c6\u03b1\u03af\u03bd\u03b7<\/li>\n\n\n\n<li>Meloxicam<\/li>\n\n\n\n<li>Naproxen<\/li>\n\n\n\n<li>Piroxicam<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f\u03b9 \u03c0\u03b9\u03bf \u03ba\u03bf\u03b9\u03bd\u03ad\u03c2 \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bf\u03c5\u03c3\u03af\u03b5\u03c2 \u03c4\u03c9\u03bd \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03c9\u03bd (COX-2) \u03b5\u03af\u03bd\u03b1\u03b9<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Celecoxib<\/li>\n\n\n\n<li>Etoricoxib<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03c1\u03bf\u03c6\u03b5\u03ba\u03bf\u03be\u03af\u03bc\u03c0\u03b7 (\u03bb\u03cc\u03b3\u03c9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae\u03c2 \u03c0\u03c1\u03bf\u03c3\u03b2\u03bf\u03bb\u03ae\u03c2) \u03ba\u03b1\u03b9 \u03b7 \u03b2\u03b1\u03bb\u03b4\u03b5\u03ba\u03bf\u03be\u03af\u03bc\u03c0\u03b7 \u03b1\u03c0\u03bf\u03c3\u03cd\u03c1\u03b8\u03b7\u03ba\u03b1\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b1\u03b3\u03bf\u03c1\u03ac.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03b1 \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ac \u039c\u03a3\u0391\u03a6 COX-2 \u03b4\u03b5\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c7\u03bf\u03c1\u03b7\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c3\u03c4\u03b5\u03c6\u03b1\u03bd\u03b9\u03b1\u03af\u03b1 \u03bd\u03cc\u03c3\u03bf (\u03a3\u039d) \u03ae \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03b2\u03bf\u03bb\u03ae, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03b5\u03c5\u03bd\u03bf\u03bf\u03cd\u03bd \u03b1\u03c5\u03c4\u03ad\u03c2 \u03c4\u03b9\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5\u03c2.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"DMARD\"><\/span>DMARD<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1 \u03c4\u03c9\u03bd DMARD \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03bf\u03c5\u03c3\u03af\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b1\u03bd\u03b1\u03ba\u03bf\u03c5\u03c6\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 (\u03cc\u03c0\u03c9\u03c2 \u03c4\u03b1 \u039c\u03a3\u0391\u03a6), \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 <strong>\u03bd\u03b1 \u03b5\u03c0\u03b9\u03b2\u03c1\u03b1\u03b4\u03cd\u03bd\u03bf\u03c5\u03bd \u03ae \u03bd\u03b1 \u03c3\u03c4\u03b1\u03bc\u03b1\u03c4\u03ae\u03c3\u03bf\u03c5\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03ac \u03c4\u03b7\u03bd \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5<\/strong> \u03ba\u03b1\u03b9 \u03c4\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03b1.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Beispiel_ARLA-Patient_%E2%80%93_NSARs_und_DMARD\"><\/span>\u03a0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2 ARLA - \u039c\u03a3\u0391\u03a6 \u03ba\u03b1\u03b9 DMARDs<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u0391\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2: \u03ac\u03bd\u03b4\u03c1\u03b1\u03c2 42 \u03b5\u03c4\u03ce\u03bd \u03bc\u03b5 ARLA (\u03bc\u03bf\u03bd\u03bf\u03b1\u03c1\u03b8\u03c1\u03af\u03c4\u03b9\u03b4\u03b1 \u03b3\u03cc\u03bd\u03b1\u03c4\u03bf\u03c2 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc Lyme)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0391\u03c1\u03c7\u03b9\u03ba\u03ac:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Naproxen 500 mg 2x \u03b7\u03bc\u03b5\u03c1\u03b7\u03c3\u03af\u03c9\u03c2<\/li>\n\n\n\n<li>\u039f\u03bc\u03b5\u03c0\u03c1\u03b1\u03b6\u03cc\u03bb\u03b7 20 mg \u03bc\u03af\u03b1 \u03c6\u03bf\u03c1\u03ac \u03c4\u03b7\u03bd \u03b7\u03bc\u03ad\u03c1\u03b1 (\u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03c3\u03c4\u03bf\u03bc\u03ac\u03c7\u03bf\u03c5)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a0\u03cc\u03bd\u03bf\u03c2 7\/10<br>\u039a\u03bf\u03b9\u03bd\u03ae \u03c3\u03c5\u03bb\u03bb\u03bf\u03b3\u03ae 200 ml<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039c\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc 2 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2<\/strong>:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a0\u03cc\u03bd\u03bf\u03c2 4\/10 (\u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u201e\u03b5\u03c5\u03b5\u03be\u03af\u03b1\u201c)<br>\u039a\u03bf\u03b9\u03bd\u03ae \u03c3\u03c5\u03bb\u03bb\u03bf\u03b3\u03ae \u03b1\u03ba\u03cc\u03bc\u03b1 180 ml <br>\u039f\u03af\u03b4\u03b7\u03bc\u03b1 \u03c3\u03c7\u03b5\u03b4\u03cc\u03bd \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b1<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039a\u03bb\u03b9\u03bc\u03ac\u03ba\u03c9\u03c3\u03b7 \u03c3\u03b5 DMARD:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>+ \u03bc\u03b5\u03b8\u03bf\u03c4\u03c1\u03b5\u03be\u03ac\u03c4\u03b7 15 mg\/\u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b1<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u03ae <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>+ \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 (TNFi \u03ae JAKi)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039c\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc 8-12 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a0\u03cc\u03bd\u03bf\u03c2 0-1\/10<br>\u0391\u03c1\u03b8\u03c1\u03b9\u03ba\u03ae \u03c3\u03c5\u03bb\u03bb\u03bf\u03b3\u03ae &lt; 50 ml<br>\u0391\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2<br>\u0397 \u03cd\u03c6\u03b5\u03c3\u03b7 \u03b5\u03c0\u03b9\u03c4\u03b5\u03cd\u03c7\u03b8\u03b7\u03ba\u03b5!<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Biologika\"><\/span>\u0392\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03b1 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b2\u03b9\u03bf\u03c4\u03b5\u03c7\u03bd\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bc\u03b5\u03bd\u03b1, \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b1 \u03bc\u03cc\u03c1\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c9\u03c2 \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03bf \u03c4\u03b9\u03c2 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03b5\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2, \u03c4\u03b1 \u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03ca\u03ba\u03ac \u03bf\u03be\u03ad\u03b1 \u03ae \u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1, \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b4\u03b5\u03bd \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c7\u03bf\u03c1\u03b7\u03b3\u03b7\u03b8\u03bf\u03cd\u03bd \u03c3\u03b5 \u03bc\u03bf\u03c1\u03c6\u03ae \u03b4\u03b9\u03c3\u03ba\u03af\u03c9\u03bd \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03cc\u03c9\u03c1\u03b7\u03c2 \u03b4\u03b9\u03ac\u03c3\u03c0\u03b1\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf \u03bf\u03be\u03cd \u03c4\u03bf\u03c5 \u03c3\u03c4\u03bf\u03bc\u03ac\u03c7\u03bf\u03c5, \u03b1\u03bb\u03bb\u03ac \u03bc\u03cc\u03bd\u03bf \u03c9\u03c2 \u03c5\u03c0\u03bf\u03b4\u03cc\u03c1\u03b9\u03b5\u03c2 \u03b5\u03bd\u03ad\u03c3\u03b5\u03b9\u03c2 \u03ae \u03b5\u03b3\u03c7\u03cd\u03c3\u03b5\u03b9\u03c2. \u039c\u03cc\u03bd\u03bf \u03bf\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 JAK \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c3\u03c4\u03cc\u03bc\u03b1.<br>\u039c\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b9\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03af\u03bd\u03b5\u03c2, \u03c3\u03c4\u03bf\u03c5\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03ae \u03c3\u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2. \u0397 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03ad\u03bd\u03b1 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf (\u03c4\u03bf 1982 \u03b3\u03b9\u03b1 \u03c0\u03c1\u03ce\u03c4\u03b7 \u03c6\u03bf\u03c1\u03ac).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03c4\u03bf \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf \u03c4\u03b7\u03c2 ARLA, \u03c7\u03c9\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c4\u03ad\u03c3\u03c3\u03b5\u03c1\u03b9\u03c2 \u03b9\u03b5\u03c1\u03b1\u03c1\u03c7\u03af\u03b5\u03c2<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">1\u03b7 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae - <strong>\u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03bf\u03c5 TNF-\u03b1 (TNFi)<\/strong> - \u0391\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf 50-70% \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc 4-8 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Adalimumab<\/li>\n\n\n\n<li>Infliximab<\/li>\n\n\n\n<li>Etanercept<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">2\u03b7 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae - <strong>\u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 IL-6 (IL-6i)<\/strong> - \u0391\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c3\u03c4\u03bf 50-60% \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc 4-12 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Tocilizumab<\/li>\n\n\n\n<li>Sarilumab<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u0395\u03c0\u03af\u03c3\u03b7\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03b1\u03bd\u03c4\u03b1\u03c0\u03bf\u03ba\u03c1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd TNFi (~30-50% \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">3\u03b7 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae - <strong>\u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 JAK (JAKi) <\/strong>- \u0391\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03ae\u03b4\u03b7 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc 2-4 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 - \u03b1\u03ba\u03cc\u03bc\u03b1 \u03c3\u03b5 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7<br>\u039c\u03c0\u03bb\u03bf\u03ba\u03ac\u03c1\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd JAK1 (\u03c0\u03c1\u03c9\u03c4\u03bf\u03b3\u03b5\u03bd\u03ae, \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae), \u03c4\u03b7\u03bd JAK2 (\u03b4\u03b5\u03c5\u03c4\u03b5\u03c1\u03bf\u03b3\u03b5\u03bd\u03ae, \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae) \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd TYK2 (\u03b4\u03b5\u03c5\u03c4\u03b5\u03c1\u03bf\u03b3\u03b5\u03bd\u03ae, \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae), \u03b3\u03b9' \u03b1\u03c5\u03c4\u03cc \u03ba\u03b1\u03b9 \u03b7 STAT3 \u03b4\u03b5\u03bd \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c6\u03c9\u03c3\u03c6\u03bf\u03c1\u03c5\u03bb\u03b9\u03c9\u03b8\u03b5\u03af \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c0\u03ce\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03b1\u03bd\u03b5\u03bd\u03b5\u03c1\u03b3\u03ae \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03b5\u03be\u03b1\u03c1\u03c4\u03ce\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd IL-6 \u03b4\u03b5\u03bd \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03ac\u03c6\u03bf\u03bd\u03c4\u03b1\u03b9. \u0397 JAK3, \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ac\u03bb\u03bb\u03b7 \u03c0\u03bb\u03b5\u03c5\u03c1\u03ac, \u03b4\u03b5\u03bd \u03bc\u03c0\u03bb\u03bf\u03ba\u03ac\u03c1\u03b5\u03c4\u03b1\u03b9, \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03b3\u03b9\u03b1 \u03bc\u03b9\u03b1 \u03b2\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03ac\u03bc\u03c5\u03bd\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03c2 \u03bb\u03bf\u03af\u03bc\u03c9\u03be\u03b7\u03c2 (\u03c0\u03b7\u03b3\u03ae - \u03c0\u03bb\u03ae\u03c1\u03b5\u03c2 \u03ba\u03b5\u03af\u03bc\u03b5\u03bd\u03bf \u03bc\u03b5 \u03ba\u03cc\u03c3\u03c4\u03bf\u03c2): <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/312615\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u03a7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b1\u03c1\u03b8\u03c1\u03af\u03c4\u03b9\u03b4\u03b1 Lyme. \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b1\u03bd\u03bf\u03c3\u03bf\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03c1\u03b5\u03c5\u03bc\u03b1\u03c4\u03bf\u03b5\u03b9\u03b4\u03ae \u03b1\u03c1\u03b8\u03c1\u03af\u03c4\u03b9\u03b4\u03b1<\/a>).<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Upadacitinib<\/li>\n\n\n\n<li>Baricitinib<\/li>\n\n\n\n<li>Tofacitinib<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">4\u03b7 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae - <strong>\u0395\u03be\u03b1\u03bd\u03c4\u03bb\u03b7\u03c4\u03ad\u03c2 \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u0392<\/strong> - \u0391\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c3\u03c4\u03bf 40-50% - \u03bc\u03cc\u03bd\u03bf \u03b3\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03bc\u03b7 \u03b1\u03bd\u03c4\u03b1\u03c0\u03bf\u03ba\u03c1\u03b9\u03bd\u03cc\u03bc\u03b5\u03bd\u03bf\u03c5\u03c2 \u03c3\u03b5 TNFi + IL-6i + JAKi<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Rituximab<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Huaier-Pilz_%E2%80%93_eine_Alternative\"><\/span>\u039c\u03b1\u03bd\u03b9\u03c4\u03ac\u03c1\u03b9 Huaier - \u03bc\u03b9\u03b1 \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03bb\u03cd\u03c3\u03b7;<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf <a href=\"https:\/\/aditum.org\/journals\/international-journal-of-medical-case-reports-and-medical-research\/archive\/967\" target=\"_blank\" rel=\"noreferrer noopener\">\u039c\u03b5\u03bb\u03ad\u03c4\u03b7 Tanaka<\/a> \u03c1\u03af\u03c7\u03bd\u03b5\u03b9 \u03c6\u03c9\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03c4\u03b7\u03c2 Huaier \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03ba\u03ac\u03b8\u03b5 \u03c0\u03c1\u03bf\u03ad\u03bb\u03b5\u03c5\u03c3\u03b7\u03c2 (\u03bc\u03b5 \u03b5\u03be\u03b1\u03af\u03c1\u03b5\u03c3\u03b7 \u03c4\u03bf\u03c5\u03c2 \u03cc\u03b3\u03ba\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5 \u03b5\u03b3\u03ba\u03b5\u03c6\u03ac\u03bb\u03bf\u03c5, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03c4\u03b1 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b1 \u03bc\u03cc\u03c1\u03b9\u03b1 \u03c4\u03c9\u03bd \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03b4\u03b5\u03bd \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c0\u03b5\u03c1\u03ac\u03c3\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03b9\u03ba\u03cc \u03c6\u03c1\u03b1\u03b3\u03bc\u03cc).<br>\u03a5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03ad\u03bd\u03b1 \u03be\u03b5\u03c7\u03c9\u03c1\u03b9\u03c3\u03c4\u03cc <a href=\"https:\/\/csiag.eu\/el\/%ce%bc%ce%b1%ce%bd%ce%b9%cf%84%ce%ac%cf%81%ce%b9-huaier-%cf%83%cf%84%ce%b7-%ce%b8%ce%b5%cf%81%ce%b1%cf%80%ce%b5%ce%af%ce%b1-%cf%84%ce%bf%cf%85-%ce%ba%ce%b1%cf%81%ce%ba%ce%af%ce%bd%ce%bf%cf%85\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u03a3\u03c5\u03bd\u03b5\u03b9\u03c3\u03c6\u03bf\u03c1\u03ac<\/a>, \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bc\u03b5 <a href=\"https:\/\/csiag.eu\/el\/%ce%bc%ce%b1%ce%bd%ce%b9%cf%84%ce%ac%cf%81%ce%b9-huaier-%cf%83%cf%84%ce%b7-%ce%b8%ce%b5%cf%81%ce%b1%cf%80%ce%b5%ce%af%ce%b1-%cf%84%ce%bf%cf%85-%ce%ba%ce%b1%cf%81%ce%ba%ce%af%ce%bd%ce%bf%cf%85\/#Dosierungsempfehlung\" target=\"_blank\" rel=\"noreferrer noopener\">\u039f\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2<\/a> \u03ba\u03b1\u03b9 <a href=\"https:\/\/nutrimentas-shop.de\/products\/vitalpilz-huaier-trametes-robiniophila-fur-wissenschaftliche-zwecke\" target=\"_blank\" rel=\"noreferrer noopener\">\u03a0\u03b7\u03b3\u03ae \u03b5\u03c6\u03bf\u03b4\u03b9\u03b1\u03c3\u03bc\u03bf\u03cd<\/a> \u03c4\u03c9\u03bd \u03ba\u03cc\u03ba\u03ba\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03c3\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03bc\u03b5 32 \u03c0\u03bf\u03bb\u03c5\u03c3\u03b1\u03ba\u03c7\u03b1\u03c1\u03af\u03c4\u03b5\u03c2 %.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\"><strong>\u03a0\u03c1\u03bf\u03c3\u03bf\u03c7\u03ae<\/strong>:<br>Dosierungsempfehlungen basieren ausschlie\u00dflich auf dem unter dem o.g. Link &#8222;Bezugsquelle&#8220; aufgef\u00fchrten Produkt, da, Stand 04.2026, nur dieses \u00fcber die nachgewiesenen 32% Polysaccahride und 58% \u03b2-<mark>Glukane<\/mark> verf\u00fcgt, die auch durch unabh\u00e4ngige Analyse-Daten (siehe die Links auf der Produktseite weiter unten) best\u00e4tigt sind.<\/p>\n<\/blockquote>\n\n\n\n<p class=\"wp-block-paragraph\">\u039c\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03b1 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03c5 \u03bc\u03b1\u03bd\u03b9\u03c4\u03b1\u03c1\u03b9\u03bf\u03cd Huaier \u03ad\u03c7\u03bf\u03c5\u03bd \u03ad\u03bd\u03b1 \u03b5\u03c5\u03c1\u03cd \u03c6\u03ac\u03c3\u03bc\u03b1 \u03ba\u03b1\u03b8\u03b1\u03c1\u03ac \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03b9\u03b4\u03b9\u03bf\u03c4\u03ae\u03c4\u03c9\u03bd. \u0395\u03af\u03bd\u03b1\u03b9 \u03c3\u03b5 \u03b8\u03ad\u03c3\u03b7 \u03bd\u03b1 \u03b5\u03c0\u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03c4\u03b1 \u03bb\u03b1\u03bd\u03b8\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c3\u03c4\u03bf \u03b1\u03c1\u03c7\u03b9\u03ba\u03cc \u03c6\u03ac\u03c3\u03bc\u03b1 \u03c4\u03c9\u03bd \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ce\u03bd \u03c4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03c4\u03b1 \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1\u03c4\u03af\u03b6\u03bf\u03c5\u03bd \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b5\u03cd\u03b8\u03c5\u03bd\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03ae \u03bd\u03b1 \u03b1\u03c0\u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03c1\u03c5\u03b8\u03bc\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b1 \u03c0\u03ac\u03bd\u03c9 \u03ae \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b1 \u03ba\u03ac\u03c4\u03c9. \u038c\u03bb\u03b5\u03c2 \u03bf\u03b9 \u03c3\u03c5\u03bd\u03b8\u03ae\u03ba\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03b2\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 \u03c4\u03bf\u03c5 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd \u03b5\u03cd\u03c1\u03bf\u03c5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b1 \u03c5\u03c0\u03b5\u03c1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ad\u03c2 \u03ae \u03b1\u03bd\u03b1\u03c3\u03c4\u03b1\u03bb\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03b1 \u03c3\u03ae\u03bc\u03b1\u03c4\u03b1. \u03a4\u03b1 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03c2 Huaier \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b5 \u03b8\u03ad\u03c3\u03b7 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ae\u03c3\u03bf\u03c5\u03bd \u03b5\u03c0\u03b9\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd \u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03ac \u03c3\u03c9\u03c3\u03c4\u03ae \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03c6\u03bf\u03c1\u03ac.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03c4\u03b9\u03ba\u03bf\u03af \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b7\u03bb\u03b9\u03c3\u03bc\u03bf\u03af \u03bc\u03b5 \u03c4\u03b7\u03bd ARLA, \u03b3\u03b9' \u03b1\u03c5\u03c4\u03cc \u03ba\u03b1\u03b9 \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c4\u03ad\u03c3\u03c3\u03b5\u03c1\u03b1 \u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03b1 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ac \u03c3\u03b7\u03bc\u03b5\u03af\u03b1 \u03c0\u03b1\u03c1\u03ad\u03bc\u03b2\u03b1\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c4\u03bf Huaier \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c3\u03ba\u03ae\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03ae \u03c4\u03bf\u03c5 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 ARLA:<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"NF-%CE%BAB-Pathway-Hemmung_Plasma-Membran-Signalisierung\"><\/span>\u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03bf\u03c5 \u03bc\u03bf\u03bd\u03bf\u03c0\u03b1\u03c4\u03b9\u03bf\u03cd NF-\u03ba\u0392 (\u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7 \u03bc\u03ad\u03c3\u03c9 \u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03bd\u03b7\u03c2)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1-\u03bc\u03bf\u03bb\u03c5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03c1\u03b8\u03c1\u03af\u03c4\u03b9\u03b4\u03b1 Lyme, \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c4\u03c5\u03c7\u03ae \u03b1\u03bd\u03c4\u03b9\u03b2\u03b9\u03bf\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03c9\u03bd \u03b2\u03bf\u03c1\u03c1\u03b5\u03bb\u03af\u03c9\u03bd, \u03b7 \u03bb\u03b5\u03b3\u03cc\u03bc\u03b5\u03bd\u03b7 <em>\u03b5\u03c0\u03af\u03bc\u03bf\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03bf\u03b3\u03bb\u03c5\u03ba\u03ac\u03bd\u03b5\u03c2<\/em>, \u03c4\u03b1 \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03c5 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03bf\u03cd \u03c4\u03bf\u03b9\u03c7\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c4\u03c9\u03bd \u03bd\u03b5\u03ba\u03c1\u03ce\u03bd \u03b2\u03bf\u03c1\u03c1\u03b5\u03bb\u03af\u03c9\u03bd, \u03c3\u03c4\u03bf \u03b1\u03c1\u03b8\u03c1\u03b9\u03ba\u03cc \u03c5\u03b3\u03c1\u03cc \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03b9\u03c3\u03c4\u03cc \u03c4\u03b7\u03c2 \u03ac\u03c1\u03b8\u03c1\u03c9\u03c3\u03b7\u03c2. \u0391\u03c5\u03c4\u03ad\u03c2 \u03bf\u03b9 \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03bf\u03b3\u03bb\u03c5\u03ba\u03ac\u03bd\u03b5\u03c2 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c7\u03ce\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1, \u03b9\u03b4\u03af\u03c9\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf <em>\u03a5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2 2 \u03c4\u03cd\u03c0\u03bf\u03c5 Toll<\/em> (TLR2), \u03bf \u03bf\u03c0\u03bf\u03af\u03bf\u03c2 \u03b5\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03bc\u03b1\u03ba\u03c1\u03bf\u03c6\u03ac\u03b3\u03c9\u03bd, \u03c4\u03c9\u03bd \u03b4\u03b5\u03bd\u03b4\u03c1\u03b9\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c4\u03bf\u03c5 \u03ad\u03bc\u03c6\u03c5\u03c4\u03bf\u03c5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u038c\u03c4\u03b1\u03bd \u03bf TLR2 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03b9\u03c2 \u03b5\u03c0\u03af\u03bc\u03bf\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03bf\u03b3\u03bb\u03c5\u03ba\u03ac\u03bd\u03b5\u03c2, \u03c4\u03af\u03b8\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03ba\u03af\u03bd\u03b7\u03c3\u03b7 \u03ad\u03bd\u03b1\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c1\u03c1\u03ac\u03ba\u03c4\u03b7\u03c2 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03c4\u03b7\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03ce\u03bd <em>\u039f\u03b4\u03cc\u03c2 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7\u03c2 NF-\u03ba\u0392<\/em> \u03bf\u03b4\u03b7\u03b3\u03b5\u03af. \u0391\u03c5\u03c4\u03cc \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03cc\u03c3\u03bb\u03b7\u03c8\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03b3\u03ad\u03c9\u03bd, \u03cc\u03c0\u03c9\u03c2 \u03bf\u03b9 <em>TIRAP<\/em> \u03ba\u03b1\u03b9 <em>MyD88<\/em> \u03c3\u03c4\u03bf\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 TLR2.<br>\u0391\u03c5\u03c4\u03ad\u03c2 \u03bf\u03b9 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03b3\u03b5\u03af\u03c2 \u03c3\u03c4\u03c1\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03ad\u03bd\u03b1 \u03c3\u03cd\u03bc\u03c0\u03bb\u03b5\u03b3\u03bc\u03b1 \u03ba\u03b9\u03bd\u03b1\u03c3\u03ce\u03bd, \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03b7\u03c2 \u03c4\u03b7\u03c2 <em>\u03a3\u03cd\u03bc\u03c0\u03bb\u03b5\u03b3\u03bc\u03b1 IKK<\/em> (\u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03ba\u0392 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2), \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 <em>I\u03baB\u03b1<\/em> \u03c6\u03c9\u03c3\u03c6\u03bf\u03c1\u03c5\u03bb\u03b9\u03c9\u03bc\u03ad\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c0\u03ce\u03c2 \u03b5\u03c0\u03b9\u03c3\u03b7\u03bc\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03b3\u03b9\u03b1 \u03c0\u03c1\u03c9\u03c4\u03b5\u03b1\u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03b9\u03ba\u03bf\u03b4\u03cc\u03bc\u03b7\u03c3\u03b7. \u039c\u03b5 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03b9\u03ba\u03bf\u03b4\u03cc\u03bc\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 I\u03baB\u03b1, \u03c4\u03bf <em>\u0394\u03b9\u03bc\u03b5\u03c1\u03ad\u03c2 \u03c4\u03bf\u03c5 \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03b9\u03ba\u03bf\u03cd \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 p50\/p65<\/em> \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03b5\u03c1\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd NF-\u03ba\u0392 \u03ba\u03b1\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b5\u03c4\u03b1\u03c6\u03b5\u03c1\u03b8\u03b5\u03af \u03c3\u03c4\u03bf\u03bd \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1 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\u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae \u03c4\u03bf\u03c5\u03c2. \u0391\u03c5\u03c4\u03cc \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03b5\u03c7\u03ae, \u03b5\u03c0\u03af\u03bc\u03bf\u03bd\u03b7 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae <em>TNF-\u03b1, IL-6, IL-1\u03b2, IL-8<\/em> \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03ba\u03af\u03bd\u03b5\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03b7 <em>MCP-1<\/em> \u03ba\u03b1\u03b9 <em>KC<\/em>.<br>\u03a3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 ARLA, \u03b7 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03b1\u03c5\u03c4\u03ae \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03c4\u03bf\u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03b7. \u03a3\u03c5\u03bd\u03b5\u03c7\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2, \u03bc\u03ae\u03bd\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03cc\u03c3\u03bf \u03bf\u03b9 \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03bf\u03b3\u03bb\u03c5\u03ba\u03ac\u03bd\u03b5\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03bf\u03c5\u03bd \u03c0\u03b1\u03c1\u03bf\u03cd\u03c3\u03b5\u03c2. \u0391\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03cc \u03c0\u03c1\u03cc\u03b2\u03bb\u03b7\u03bc\u03b1: \u03b4\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03bd\u03ad\u03b1 \u03bb\u03bf\u03af\u03bc\u03c9\u03be\u03b7 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c0\u03bf\u03bb\u03b5\u03bc\u03b7\u03b8\u03b5\u03af, \u03b1\u03bb\u03bb\u03ac \u03c4\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03ba\u03bf\u03bb\u03bb\u03b7\u03bc\u03ad\u03bd\u03bf \u03c3\u03b5 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a0\u03ce\u03c2 \u03b7 Huaier \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b4\u03b9\u03b1\u03ba\u03cc\u03c8\u03b5\u03b9 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 Huaier \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bb\u03bf\u03cd\u03c3\u03b9\u03b1 \u03c3\u03b5 <em>\u03b2-\u03b3\u03bb\u03c5\u03ba\u03ac\u03bd\u03b5\u03c2<\/em> \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03bf\u03b9 <em>\u03a0\u03bf\u03bb\u03c5\u03c3\u03b1\u03ba\u03c7\u03b1\u03c1\u03af\u03c4\u03b5\u03c2<\/em>, \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c3\u03b4\u03ad\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03ad\u03bd\u03b1\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd TLR2, \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03c4\u03bf\u03c5\u03c2 \u03bb\u03b5\u03b3\u03cc\u03bc\u03b5\u03bd\u03bf\u03c5\u03c2 <em>\u03a5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2 Dectin-1<\/em> (\u0397 Dectin-1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 <em>\u03a5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2 \u03bb\u03b5\u03ba\u03c4\u03af\u03bd\u03b7\u03c2 \u03c4\u03cd\u03c0\u03bf\u03c5 C<\/em>, \u03c0\u03bf\u03c5 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03c4\u03b1 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c6\u03ac\u03b3\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b4\u03b5\u03bd\u03b4\u03c1\u03b9\u03c4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1). \u038c\u03c4\u03b1\u03bd \u03bf\u03b9 \u03b2-\u03b3\u03bb\u03c5\u03ba\u03ac\u03bd\u03b5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf Huaier \u03b4\u03b5\u03c3\u03bc\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf Dectin-1, \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c4\u03bf\u03bd NF-\u03ba\u0392, \u03b1\u03bb\u03bb\u03ac \u03bc\u03ad\u03c3\u03c9 \u03bc\u03b9\u03b1\u03c2 \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae\u03c2, \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c0\u03c1\u03bf\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03bf\u03c5\u03c2 \u03bf\u03b4\u03bf\u03cd \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7\u03c2.<br>\u0391\u03bd\u03c4\u03af \u03c4\u03bf\u03c5 \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03bf\u03cd <em>\u0394\u03b9\u03b1\u03b4\u03c1\u03bf\u03bc\u03ae TIRAP\/MyD88<\/em> \u038c\u03c0\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 TLR2, \u03b7 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc <em>Syk \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7<\/em> \u03ba\u03b1\u03b9 <em>\u039a\u03ac\u03c1\u03c4\u03b19<\/em>, \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03b5\u03af\u03b4\u03bf\u03c2 \u201e\u03c1\u03c5\u03b8\u03bc\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03bf\u03c5\u201c \u03c3\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 NF-\u03ba\u0392.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03b7 Huaier \u03b5\u03c1\u03b3\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 <em>miRNA-mediated<\/em> \u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03c0\u03bf\u03c5 \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c3\u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03af\u03b4\u03b9\u03c9\u03bd \u03c4\u03c9\u03bd \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03c4\u03bf\u03c5 NF-\u03ba\u0392. \u03a3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 microRNAs \u03c0\u03bf\u03c5 \u03c1\u03c5\u03b8\u03bc\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b1 \u03c0\u03ac\u03bd\u03c9 \u03b1\u03c0\u03cc \u03c4\u03bf Huaier (\u03cc\u03c0\u03c9\u03c2 \u03c4\u03b1 <em>miRNA-223, miRNA-146a<\/em> \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b5\u03c2), \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b1\u03c0\u03bf\u03b9\u03ba\u03bf\u03b4\u03bf\u03bc\u03ae\u03c3\u03bf\u03c5\u03bd \u03ac\u03bc\u03b5\u03c3\u03b1 \u03c4\u03bf mRNA \u03c4\u03c9\u03bd \u03c5\u03c0\u03bf\u03bc\u03bf\u03bd\u03ac\u03b4\u03c9\u03bd IKK \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 RelA (\u03c4\u03b7\u03c2 \u03c5\u03c0\u03bf\u03bc\u03bf\u03bd\u03ac\u03b4\u03b1\u03c2 p65 \u03c4\u03bf\u03c5 NF-\u03ba\u0392). \u0391\u03c5\u03c4\u03cc \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03cc \u03c3\u03cd\u03bc\u03c0\u03bb\u03b5\u03b3\u03bc\u03b1 NF-\u03ba\u0392 \u03c3\u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af, \u03b1\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03bd \u03b5\u03be\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03bc\u03bf\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03bf\u03b3\u03bb\u03c5\u03ba\u03ac\u03bd\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b4\u03b9\u03b5\u03b3\u03b5\u03af\u03c1\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd TLR2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b1\u03c5\u03c4\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03c0\u03bb\u03ae\u03c2 \u03c0\u03b1\u03c1\u03ad\u03bc\u03b2\u03b1\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 Huaier \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03c3\u03c5\u03bd\u03b5\u03c7\u03ae\u03c2 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 NF-\u03ba\u0392 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03bf\u03b3\u03bb\u03c5\u03ba\u03ac\u03bd\u03b5\u03c2 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac. \u0397 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c4\u03bf\u03c5 TNF-\u03b1 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9, \u03b7 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c4\u03b7\u03c2 IL-6 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b7 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c4\u03b7\u03c2 IL-1\u03b2 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9. \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac, \u03b1\u03c5\u03c4\u03cc \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03c4\u03b1\u03c7\u03b5\u03af\u03b1 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 C-\u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03ce\u03c3\u03b1\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 (CRP), \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03bf\u03be\u03b5\u03af\u03b1\u03c2 \u03c6\u03ac\u03c3\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd NF-\u03ba\u0392.<br>\u039c\u03b5 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf TNF-\u03b1 \u03ba\u03b1\u03b9 IL-6, \u03c0\u03bf\u03c5 \u03b4\u03c1\u03bf\u03c5\u03bd \u03c9\u03c2 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03ba\u03af\u03bd\u03b5\u03c2, \u03b7 \u03b1\u03c1\u03b8\u03c1\u03b9\u03ba\u03ae \u03c3\u03c5\u03bb\u03bb\u03bf\u03b3\u03ae \u03b1\u03c0\u03bf\u03c1\u03c1\u03bf\u03c6\u03ac\u03c4\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c4\u03b1\u03c7\u03cd\u03c4\u03b5\u03c1\u03b1, \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03c3\u03c4\u03c1\u03b1\u03c4\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03bb\u03b5\u03c5\u03ba\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03c4\u03b7\u03bd \u03ac\u03c1\u03b8\u03c1\u03c9\u03c3\u03b7. \u039f\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03c4\u03b1\u03c7\u03b5\u03af\u03b1 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bf\u03b9\u03b4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u03c0\u03cc\u03bd\u03bf\u03c5 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b9\u03c2 \u03c0\u03c1\u03ce\u03c4\u03b5\u03c2 1-2 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03c4\u03b7\u03c2 Huaier. \u0391\u03c5\u03c4\u03cc \u03c3\u03c5\u03bd\u03ac\u03b4\u03b5\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03bf\u03c5 NF-\u03ba\u0392.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"JAKSTAT-Pathway-Modulation_Endosomal-Signalisierung_IL-6-Feedback\"><\/span>\u0394\u03b9\u03b1\u03bc\u03cc\u03c1\u03c6\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bf\u03b4\u03bf\u03cd JAK\/STAT (\u03b5\u03bd\u03b4\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7 + \u03b1\u03bd\u03b1\u03c4\u03c1\u03bf\u03c6\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7 IL-6)<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">ARLA \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c5\u03c0\u03b5\u03c1\u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae <em>\u0399\u03bd\u03c4\u03b5\u03c1\u03c6\u03b5\u03c1\u03cc\u03bd\u03b5\u03c2 \u03c4\u03cd\u03c0\u03bf\u03c5 \u0399<\/em> (\u03b9\u03bd\u03c4\u03b5\u03c1\u03c6\u03b5\u03c1\u03cc\u03bd\u03b7-\u03b1 \u03ba\u03b1\u03b9 \u03b9\u03bd\u03c4\u03b5\u03c1\u03c6\u03b5\u03c1\u03cc\u03bd\u03b7-\u03b2), \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae \u03c9\u03c2 \u201e<em>\u0392\u03c1\u03cc\u03c7\u03bf\u03c2 \u03b5\u03bd\u03af\u03c3\u03c7\u03c5\u03c3\u03b7\u03c2 IFN<\/em>\u201c \u03b5\u03c0\u03b9\u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9. \u0394\u03b5\u03bd \u03c0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 TLR2 \u03c0\u03bf\u03c5 \u03bc\u03cc\u03bb\u03b9\u03c2 \u03c3\u03c5\u03b6\u03b7\u03c4\u03ae\u03c3\u03b1\u03bc\u03b5 \u03bc\u03b5 \u03c4\u03bf\u03bd NF-\u03baB. \u0391\u03bd\u03c4' \u03b1\u03c5\u03c4\u03bf\u03cd, \u03b1\u03c5\u03c4\u03cc \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03bc\u03b9\u03b1\u03c2 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bf\u03b4\u03bf\u03cd: \u03c4\u03b1 \u03b5\u03c0\u03af\u03bc\u03bf\u03bd\u03b1 \u03b2\u03bf\u03c1\u03c1\u03ad\u03bb\u03b9\u03b1 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03bf\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc <em>\u039c\u03b1\u03ba\u03c1\u03bf\u03c6\u03ac\u03b3\u03b1<\/em> \u03ba\u03b1\u03b9 <em>\u03b4\u03b5\u03bd\u03b4\u03c1\u03b9\u03c4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1<\/em> \u03c6\u03b1\u03b3\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9. \u038c\u03c4\u03b1\u03bd \u03c0\u03c1\u03bf\u03c3\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03c6\u03b1\u03b3\u03cc\u03c3\u03c9\u03bc\u03b1, \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b5\u03bd\u03b4\u03bf\u03c3\u03c9\u03bc\u03b9\u03b1\u03ba\u03bf\u03cd\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03c4\u03cd\u03c0\u03bf\u03c5 Toll, \u03b9\u03b4\u03af\u03c9\u03c2 <em>TLR7, TLR8<\/em> \u03ba\u03b1\u03b9 <em>TLR9<\/em>. \u039f\u03b9 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03b1\u03c5\u03c4\u03bf\u03af \u03b2\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c3\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5 <em>\u03b5\u03bd\u03b4\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03ac\/\u03c6\u03b1\u03b3\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03ac \u03ba\u03c5\u03c3\u03c4\u03af\u03b4\u03b9\u03b1<\/em> \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03bf RNA \u03ba\u03b1\u03b9 \u03c4\u03bf DNA \u03c4\u03b7\u03c2 Borrelia.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u038c\u03c4\u03b1\u03bd \u03bf\u03b9 TLR7\/8\/9 \u03b4\u03b9\u03b5\u03b3\u03b5\u03af\u03c1\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b2\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ac \u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03ca\u03ba\u03ac \u03bf\u03be\u03ad\u03b1, \u03c0\u03c1\u03bf\u03c3\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03b3\u03ad\u03b1 <em>MyD88<\/em> \u03ae\/\u03ba\u03b1\u03b9 <em>TRIF<\/em> \u03ba\u03b1\u03b9 \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c3\u03c4\u03b7\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b9\u03bd\u03c4\u03b5\u03c1\u03c6\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2, \u03b9\u03b4\u03af\u03c9\u03c2 \u03c4\u03c9\u03bd <em>IRF3<\/em> \u03ba\u03b1\u03b9 <em>IRF7<\/em>. \u0391\u03c5\u03c4\u03bf\u03af \u03bf\u03b9 \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03b9\u03ba\u03bf\u03af \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 IRF \u03b5\u03b9\u03c3\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03c3\u03c4\u03bf\u03bd \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03be\u03b5\u03ba\u03b9\u03bd\u03bf\u03cd\u03bd \u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae \u03c4\u03c9\u03bd \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd \u03c4\u03b7\u03c2 \u03b9\u03bd\u03c4\u03b5\u03c1\u03c6\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2 \u03c4\u03cd\u03c0\u03bf\u03c5 \u0399: \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac <em>\u0399\u03bd\u03c4\u03b5\u03c1\u03c6\u03b5\u03c1\u03cc\u03bd\u03b7-\u03b2<\/em> \u03ba\u03b1\u03b9 \u03b1\u03c5\u03c4\u03cc \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1 \u03b4\u03b5\u03c5\u03c4\u03b5\u03c1\u03b5\u03cd\u03bf\u03bd \u03ba\u03cd\u03bc\u03b1 <em>\u0399\u03bd\u03c4\u03b5\u03c1\u03c6\u03b5\u03c1\u03cc\u03bd\u03b7-\u03b1<\/em>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039c\u03cc\u03bb\u03b9\u03c2 \u03b7 IFN-\u03b1 \u03ba\u03b1\u03b9 \u03b7 IFN-\u03b2 \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03b5\u03c1\u03c9\u03b8\u03bf\u03cd\u03bd \u03c3\u03c4\u03bf \u03b1\u03c1\u03b8\u03c1\u03b9\u03ba\u03cc \u03c5\u03b3\u03c1\u03cc \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf \u03b1\u03af\u03bc\u03b1, \u03b4\u03b5\u03c3\u03bc\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03b7\u03c2 \u03b9\u03bd\u03c4\u03b5\u03c1\u03c6\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2-\u03b1\/\u03b2 (IFNAR), \u03bf \u03bf\u03c0\u03bf\u03af\u03bf\u03c2 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c3\u03c7\u03b5\u03b4\u03cc\u03bd \u03c3\u03b5 \u03cc\u03bb\u03b1 \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd \u03c4\u03c9\u03bd <em>\u03a4 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03bc\u03b1\u03ba\u03c1\u03bf\u03c6\u03ac\u03b3\u03b1<\/em> \u03ba\u03b1\u03b9 <em>\u03b1\u03c1\u03b8\u03c1\u03b9\u03ba\u03bf\u03af \u03b9\u03bd\u03bf\u03b2\u03bb\u03ac\u03c3\u03c4\u03b5\u03c2<\/em>.<br>\u0397 \u03c0\u03c1\u03cc\u03c3\u03b4\u03b5\u03c3\u03b7 \u03c4\u03bf\u03c5 IFNAR \u03c0\u03c1\u03bf\u03c3\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03b4\u03cd\u03bf \u03ba\u03b9\u03bd\u03ac\u03c3\u03b5\u03c2 \u03c3\u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1: <em>JAK1<\/em> \u03ba\u03b1\u03b9 <em>TYK2<\/em>. \u0391\u03c5\u03c4\u03ad\u03c2 \u03bf\u03b9 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b5\u03c2 \u03c6\u03c9\u03c3\u03c6\u03bf\u03c1\u03c5\u03bb\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 STAT <em>STAT1<\/em> \u03ba\u03b1\u03b9 <em>STAT2<\/em> (<strong>\u03cc\u03c7\u03b9<\/strong> <em>STAT3<\/em> \u03c3\u03c4\u03b7 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03b4\u03b9\u03b1\u03b4\u03c1\u03bf\u03bc\u03ae). \u03a4\u03bf \u03c6\u03c9\u03c3\u03c6\u03bf\u03c1\u03c5\u03bb\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf STAT1\/STAT2 \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 \u03c4\u03bf <em>IRF9<\/em> \u03ad\u03bd\u03b1 \u03c3\u03cd\u03bc\u03c0\u03bb\u03b5\u03b3\u03bc\u03b1 \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03b9\u03ba\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03c0\u03bf\u03c5 <em>ISGF3<\/em> \u03ba\u03b1\u03b9 \u03b5\u03b9\u03c3\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1 \u03c4\u03bf\u03c5 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03bf\u03c5.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03c4\u03bf\u03bd \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1 \u03c4\u03bf\u03c5 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03bf\u03c5, \u03bf ISGF3 \u03c0\u03c1\u03bf\u03c3\u03b4\u03ad\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf <em>\u03a3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03b4\u03b9\u03b5\u03b3\u03b5\u03c1\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b1\u03c0\u03cc \u03b9\u03bd\u03c4\u03b5\u03c1\u03c6\u03b5\u03c1\u03cc\u03bd\u03b7<\/em> (ISREs) \u03c3\u03c4\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ad\u03c2 \u03c0\u03c1\u03bf\u03ce\u03b8\u03b7\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd <em>\u0393\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b5\u03b3\u03b5\u03af\u03c1\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b9\u03bd\u03c4\u03b5\u03c1\u03c6\u03b5\u03c1\u03cc\u03bd\u03b7<\/em> (ISGs). \u0391\u03c5\u03c4\u03ac \u03c4\u03b1 ISGs \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03cc\u03c0\u03c9\u03c2 <em>OAS<\/em> (2\u2032,5\u2032-\u03bf\u03bb\u03b9\u03b3\u03bf\u03b1\u03b4\u03b5\u03bd\u03c5\u03bb\u03b9\u03ba\u03ae \u03c3\u03c5\u03bd\u03b8\u03b5\u03c4\u03ac\u03c3\u03b7), <em>MxA<\/em> (\u03a0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 A \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03bc\u03c5\u03be\u03bf\u03ca\u03bf\u03cd), <em>PBR<\/em> (\u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b9\u03ba\u03ae \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7 R) \u03ba\u03b1\u03b9 \u03c0\u03bf\u03bb\u03bb\u03ac \u03ac\u03bb\u03bb\u03b1. \u0391\u03c5\u03c4\u03ac \u03c4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c1\u03c5\u03b8\u03bc\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b1\u03b6\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd\u03bd \u03bc\u03b9\u03b1 \u201e\u03b1\u03bd\u03c4\u03b9-\u03b9\u03b9\u03ba\u03ae \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7\u201c \u03c3\u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1. \u0391\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03c3\u03c4\u03b9\u03ba\u03cc \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b9\u03bf\u03b3\u03b5\u03bd\u03ae \u03bb\u03bf\u03af\u03bc\u03c9\u03be\u03b7, \u03b1\u03bb\u03bb\u03ac \u03c3\u03c4\u03b7\u03bd ARLA \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03c5\u03c3\u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03c3\u03c4\u03b9\u03ba\u03cc, \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03b4\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b5\u03bd\u03b5\u03c1\u03b3\u03ae \u03b9\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 \u03bb\u03bf\u03af\u03bc\u03c9\u03be\u03b7. \u03a0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03ad\u03bd\u03b1 \u03b5\u03af\u03b4\u03bf\u03c2 \u201e\u03c8\u03b5\u03c5\u03b4\u03bf\u03cd\u03c2 \u03c3\u03c5\u03bd\u03b1\u03b3\u03b5\u03c1\u03bc\u03bf\u03cd\u201c.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf \u03c0\u03c1\u03cc\u03b2\u03bb\u03b7\u03bc\u03b1 \u03b5\u03c0\u03b9\u03b4\u03b5\u03b9\u03bd\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u03b1\u03bd\u03b1\u03c4\u03c1\u03bf\u03c6\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7\u03c2: \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03c5\u03bd \u03b9\u03bd\u03c4\u03b5\u03c1\u03c6\u03b5\u03c1\u03cc\u03bd\u03b7 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03c5\u03bd \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b9\u03bd\u03c4\u03b5\u03c1\u03c6\u03b5\u03c1\u03cc\u03bd\u03b7, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c0\u03c5\u03c1\u03bf\u03b4\u03bf\u03c4\u03b5\u03af \u03b1\u03ba\u03cc\u03bc\u03b7 \u03b9\u03c3\u03c7\u03c5\u03c1\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7 IFNAR \u03c3\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03b5\u03b9\u03c1\u03ac \u03c4\u03b7\u03c2 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae ISG, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03b5\u03b9\u03c1\u03ac \u03c4\u03b7\u03c2 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7\u03c2 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae\u03c2 IFN. \u0391\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u201e<em>\u0392\u03c1\u03cc\u03c7\u03bf\u03c2 \u03b5\u03bd\u03af\u03c3\u03c7\u03c5\u03c3\u03b7\u03c2 IFN<\/em>\u201e, \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bf\u03b9\u03bc\u03ce\u03b4\u03bf\u03c5\u03c2 ARLA. \u039f \u03b2\u03c1\u03cc\u03c7\u03bf\u03c2 \u03b1\u03c5\u03c4\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03c4\u03bf\u03c4\u03c1\u03bf\u03c6\u03bf\u03b4\u03bf\u03c4\u03bf\u03cd\u03bc\u03b5\u03bd\u03bf\u03c2: \u03b1\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03b8\u03b1\u03bd\u03ac\u03c4\u03c9\u03c3\u03b7 \u03cc\u03bb\u03c9\u03bd \u03c4\u03c9\u03bd \u03b6\u03c9\u03bd\u03c4\u03b1\u03bd\u03ce\u03bd \u03b2\u03bf\u03c1\u03c1\u03b5\u03bb\u03af\u03c9\u03bd, \u03b7 \u03bf\u03b4\u03cc\u03c2 \u03b1\u03c5\u03c4\u03ae \u03c3\u03c5\u03bd\u03b5\u03c7\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03c4\u03b1 \u03bd\u03b5\u03ba\u03c1\u03ac \u03b2\u03b1\u03ba\u03c4\u03ae\u03c1\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03ca\u03ba\u03ac \u03c4\u03bf\u03c5\u03c2 \u03bf\u03be\u03ad\u03b1 \u03b5\u03be\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c6\u03b1\u03b3\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b1, \u03b1\u03c5\u03c4\u03ae \u03b7 \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 IFN \u03c4\u03cd\u03c0\u03bf\u03c5 \u0399 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03ad\u03ba\u03c4\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03a4 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03b9\u03b4\u03af\u03c9\u03c2 \u03c4\u03c9\u03bd <em>Th1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1<\/em> \u03ba\u03b1\u03b9 \u03b1\u03c1\u03b3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 <em>Th17 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1<\/em>. \u03a4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 Th17 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03cc \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc: \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 <em>IL-6<\/em> \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 <em>TGF-\u03b2<\/em>. \u039a\u03b1\u03b9 \u03b7 IL-6 \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03c4\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd NF-\u03ba\u0392, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b5\u03b3\u03b5\u03af\u03c1\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b9\u03bd\u03c4\u03b5\u03c1\u03c6\u03b5\u03c1\u03cc\u03bd\u03b7. \u0395\u03c0\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2, \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03bf\u03b4\u03bf\u03af \u03c0\u03bf\u03c5 \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c3\u03c4\u03b7\u03bd IL-6.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039c\u03cc\u03bb\u03b9\u03c2 \u03b7 IL-6 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b1\u03c1\u03bf\u03cd\u03c3\u03b1 \u03c3\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2, \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03ba\u03ac\u03c4\u03b9 \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd: \u0397 IL-6 \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03b7\u03c2 (<em>IL-6R<\/em>) \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 \u03ad\u03bd\u03b1\u03bd \u03c3\u03c5\u03bd\u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c0\u03bf\u03c5 \u03bf\u03bd\u03bf\u03bc\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 <em>gp130<\/em> \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03a4 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03c4\u03c9\u03bd \u03b1\u03c1\u03b8\u03c1\u03b9\u03ba\u03ce\u03bd \u03b9\u03bd\u03bf\u03b2\u03bb\u03b1\u03c3\u03c4\u03ce\u03bd \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u0397 \u03c0\u03c1\u03cc\u03c3\u03b4\u03b5\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ae \u03c0\u03c1\u03bf\u03c3\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b9\u03c2 JAK1 \u03ba\u03b1\u03b9 JAK2 \u03c3\u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1. \u039f\u03b9 JAK1 \u03ba\u03b1\u03b9 JAK2 \u03c6\u03c9\u03c3\u03c6\u03bf\u03c1\u03c5\u03bb\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 STAT STAT3. \u039c\u03b5 \u03c4\u03b7 \u03c6\u03c9\u03c3\u03c6\u03bf\u03c1\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ae, \u03b7 STAT3 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b5\u03b9\u03c3\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1 \u03c4\u03bf\u03c5 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03bf\u03c5, \u03cc\u03c0\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b8\u03ad\u03c3\u03b5\u03b9\u03c2 \u03c0\u03c1\u03cc\u03c3\u03b4\u03b5\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 DNA \u03ba\u03b1\u03b9 \u03be\u03b5\u03ba\u03b9\u03bd\u03ac \u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae \u03c4\u03b7\u03c2 IL-17 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03b9\u03ba\u03bf\u03cd \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 ROR\u03b3t.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0391\u03c5\u03c4\u03cc \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03bc\u03b1\u03b6\u03b9\u03ba\u03ae \u03b5\u03c0\u03ad\u03ba\u03c4\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd Th17 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03b5\u03b9\u03c1\u03ac \u03c4\u03bf\u03c5\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03c5\u03bd \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b7 IL-17. \u0397 IL-17 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c0\u03c1\u03bf\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03c1\u03b1 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03c1\u03b8\u03c1\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b9\u03bd\u03bf\u03b2\u03bb\u03ac\u03c3\u03c4\u03b5\u03c2 (\u03c4\u03b1 \u03bb\u03b5\u03b3\u03cc\u03bc\u03b5\u03bd\u03b1 FLS - \u03b9\u03bd\u03bf\u03b2\u03bb\u03b1\u03c3\u03c4\u03bf\u03b5\u03b9\u03b4\u03ae \u03b1\u03c1\u03b8\u03c1\u03b9\u03ba\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1) \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03c5\u03bd \u03b1\u03ba\u03cc\u03bc\u03b7 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b7 IL-6. \u0391\u03c5\u03c4\u03cc \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03ad\u03bd\u03b1 \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03bf \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03b1\u03bd\u03b1\u03c4\u03c1\u03bf\u03c6\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7\u03c2: IL-6 \u2192 \u03b5\u03c0\u03ad\u03ba\u03c4\u03b1\u03c3\u03b7 Th17 \u2192 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae IL-17 \u2192 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b7 IL-6 \u03b1\u03c0\u03cc FLS \u2192 \u03b1\u03ba\u03cc\u03bc\u03b1 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b7 Th17 \u2192 \u03b1\u03ba\u03cc\u03bc\u03b1 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b7 IL-17. \u038c\u03c0\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03b2\u03c1\u03cc\u03c7\u03bf \u03b5\u03bd\u03af\u03c3\u03c7\u03c5\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 IFN, \u03b1\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03c4\u03bf\u03c4\u03c1\u03bf\u03c6\u03bf\u03b4\u03bf\u03c4\u03bf\u03cd\u03bc\u03b5\u03bd\u03bf \u03ba\u03b1\u03b9 \u03b4\u03af\u03bd\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd ARLA \u03c4\u03bf\u03bd \u03c7\u03c1\u03cc\u03bd\u03b9\u03bf, \u03b4\u03cd\u03c3\u03ba\u03bf\u03bb\u03b1 \u03b5\u03bb\u03b5\u03b3\u03c7\u03cc\u03bc\u03b5\u03bd\u03bf \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03ae\u03c1\u03b1 \u03c4\u03b7\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a0\u03ce\u03c2 \u03b7 Huaier \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b4\u03b9\u03b1\u03ba\u03cc\u03c8\u03b5\u03b9 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 Huaier \u03c0\u03b1\u03c1\u03b5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9 JAK\/STAT \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03c0\u03b9\u03bf \u03b8\u03b5\u03bc\u03b5\u03bb\u03b9\u03ce\u03b4\u03b5\u03c2 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03b1\u03c0\u03cc \u03c4\u03bf \u03bd\u03b1 \u03bc\u03c0\u03bb\u03bf\u03ba\u03ac\u03c1\u03b5\u03b9 \u03ac\u03bc\u03b5\u03c3\u03b1 \u03c4\u03b7\u03bd JAK1 \u03ae \u03c4\u03b7\u03bd JAK2 (\u03ba\u03b1\u03b8\u03ce\u03c2 <em>\u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 JAK<\/em> \u03cc\u03c0\u03c9\u03c2 <em>Upadacitinib<\/em> do). <strong>\u0391\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1, \u03bf Huaier \u03b4\u03c1\u03b1 \u03bc\u03ad\u03c3\u03c9 \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03b9\u03ba\u03ae\u03c2 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03c4\u03b7 \u03bc\u03b5\u03c3\u03bf\u03bb\u03ac\u03b2\u03b7\u03c3\u03b7 miRNA<\/strong>. \u0395\u03b9\u03b4\u03b9\u03ba\u03ac microRNAs \u03c0\u03bf\u03c5 \u03c1\u03c5\u03b8\u03bc\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03c0\u03bf\u03bb\u03c5\u03c3\u03b1\u03ba\u03c7\u03b1\u03c1\u03af\u03c4\u03b5\u03c2 Huaier \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03ad\u03c6\u03bf\u03c5\u03bd \u03ae \u03b1\u03c0\u03bf\u03b4\u03bf\u03bc\u03bf\u03cd\u03bd \u03c4\u03bf \u03af\u03b4\u03b9\u03bf \u03c4\u03bf mRNA \u03c4\u03c9\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd JAK.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0391\u03c5\u03c4\u03cc \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03b5\u03bd\u03cc\u03c2 \u03ba\u03bf\u03bc\u03c8\u03bf\u03cd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03b9\u03ba\u03bf\u03cd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd: \u03cc\u03c4\u03b1\u03bd \u03bf\u03b9 \u03c0\u03bf\u03bb\u03c5\u03c3\u03b1\u03ba\u03c7\u03b1\u03c1\u03af\u03c4\u03b5\u03c2 Huaier \u03c3\u03c5\u03bd\u03b4\u03ad\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf Dectin-1 \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b5\u03b3\u03b5\u03af\u03c1\u03bf\u03c5\u03bd \u03c4\u03bf \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf \u03bc\u03b5 \u03c3\u03ae\u03bc\u03b1\u03c4\u03b1, \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03bc\u03cc\u03bd\u03bf \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7\u03c2, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03ad\u03bd\u03b6\u03c5\u03bc\u03b1 \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1\u03c2 miRNA \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9. \u0391\u03c5\u03c4\u03ac \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c3\u03c4\u03b7 \u03b2\u03b9\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7 \u03c0\u03bf\u03bb\u03bb\u03ce\u03bd \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03b9 \u03bc\u03b7 \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03ce\u03bd miRNAs. \u039f\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03ac \u03c4\u03b1 miRNAs, \u03cc\u03c0\u03c9\u03c2 \u03c4\u03b1 <strong>miR-223, miR-146a<\/strong> \u03ba\u03b1\u03b9 <strong>miR-34a<\/strong>, \u03ad\u03c7\u03bf\u03c5\u03bd \u03b8\u03ad\u03c3\u03b5\u03b9\u03c2 \u03c0\u03c1\u03cc\u03c3\u03b4\u03b5\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b7\u03bd 3\u2032 \u03b1\u03bc\u03b5\u03c4\u03ac\u03c6\u03c1\u03b1\u03c3\u03c4\u03b7 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae (<strong>3\u2032-UTR<\/strong>) \u03b1\u03c0\u03cc <em>JAK1, JAK2<\/em> \u03ba\u03b1\u03b9 <em>STAT3 mRNA<\/em>.<br>\u038c\u03c4\u03b1\u03bd \u03b1\u03c5\u03c4\u03ac \u03c4\u03b1 miRNAs \u03c5\u03b2\u03c1\u03b9\u03b4\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03c4\u03b9\u03c2 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03c5\u03c7\u03af\u03b5\u03c2, \u03b5\u03c0\u03b9\u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf mRNA \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03b9\u03ba\u03bf\u03b4\u03cc\u03bc\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bc\u03b2\u03bf\u03bb\u03ae\u03c2 RNA \u03b1\u03c0\u03cc \u03c4\u03bf <strong>\u03a3\u03cd\u03bc\u03c0\u03bb\u03b5\u03b3\u03bc\u03b1 RISC<\/strong> (RNA-Induced Silencing Complex). \u03a4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03bf mRNA \u03b1\u03c0\u03bf\u03b9\u03ba\u03bf\u03b4\u03bf\u03bc\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03bf\u03b9 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03b4\u03b5\u03bd \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03bb\u03ad\u03bf\u03bd \u03c4\u03cc\u03c3\u03bf \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039c\u03ad\u03c3\u03b1 \u03c3\u03b5 \u03bb\u03af\u03b3\u03b5\u03c2 \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2 \u03ad\u03c9\u03c2 \u03bc\u03b9\u03b1 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b1 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03ad\u03ba\u03b8\u03b5\u03c3\u03b7 \u03c3\u03c4\u03bf Huaier, \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b1\u03c0\u03bb\u03ac <strong>\u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf JAK1-, JAK2-<\/strong> \u03ba\u03b1\u03b9 <strong>\u03a0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 STAT3<\/strong>. \u0391\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03b8\u03b5\u03bc\u03b5\u03bb\u03b9\u03ce\u03b4\u03b5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b1\u03c0\u03bb\u03ae \u03c0\u03b1\u03c1\u03b5\u03bc\u03c0\u03cc\u03b4\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2. \u03a3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03bf \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03c0\u03b1\u03b8\u03b5\u03af \u03bd\u03b1 \u03c6\u03c9\u03c3\u03c6\u03bf\u03c1\u03c5\u03bb\u03b9\u03ce\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd JAK, \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03bc\u03cc\u03c1\u03b9\u03b1 JAK \u03b3\u03b9\u03b1 \u03c6\u03c9\u03c3\u03c6\u03bf\u03c1\u03c5\u03bb\u03af\u03c9\u03c3\u03b7. \u03a4\u03bf <strong>\u0391\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd \u03c0\u03bf\u03c5 \u03b5\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd JAK<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 <strong>\u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0391\u03c5\u03c4\u03ae \u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 JAK \u03b4\u03b9\u03b1\u03ba\u03cc\u03c0\u03c4\u03b5\u03b9 \u03c4\u03bf\u03bd \u03b2\u03c1\u03cc\u03c7\u03bf \u03b5\u03bd\u03af\u03c3\u03c7\u03c5\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 IFN \u03c4\u03cd\u03c0\u03bf\u03c5 \u0399. \u0391\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03bd \u03bf\u03b9 TLR7\/8\/9 \u03c3\u03c5\u03bd\u03b5\u03c7\u03af\u03c3\u03bf\u03c5\u03bd \u03bd\u03b1 \u03b5\u03c0\u03b9\u03c7\u03b5\u03b9\u03c1\u03bf\u03cd\u03bd \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b9\u03bd\u03c4\u03b5\u03c1\u03c6\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2, \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03c5\u03bd IFN-\u03b1\/\u03b2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 JAK1\/TYK2, \u03bf\u03c0\u03cc\u03c4\u03b5 \u03b7 STAT1\/STAT2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c6\u03c9\u03c3\u03c6\u03bf\u03c1\u03c5\u03bb\u03b9\u03c9\u03b8\u03b5\u03af \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac. \u0391\u03c5\u03c4\u03cc \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 ISGF3, \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03b7 \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae \u03c4\u03bf\u03c5 ISG \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c0\u03ce\u03c2 <strong>\u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u201e\u03b1\u03bd\u03c4\u03b9-\u03b9\u03b9\u03ba\u03ae \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7\u201c<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b1, \u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd JAK1 \u03ba\u03b1\u03b9 JAK2 \u03b4\u03b9\u03b1\u03ba\u03cc\u03c0\u03c4\u03b5\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c4\u03bf\u03bd \u03b2\u03c1\u03cc\u03c7\u03bf \u03b1\u03bd\u03b1\u03c4\u03c1\u03bf\u03c6\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 IL-6. \u0391\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03bd \u03b7 IL-6 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b1\u03c1\u03bf\u03cd\u03c3\u03b1 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03c3\u03bc\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd IL-6R \u03c3\u03c4\u03b1 \u03a4 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03b7 JAK1 \u03ba\u03b1\u03b9 JAK2 \u03b3\u03b9\u03b1 \u03c6\u03c9\u03c3\u03c6\u03bf\u03c1\u03c5\u03bb\u03af\u03c9\u03c3\u03b7, \u03b5\u03c0\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03c4\u03bf STAT3 \u03c6\u03c9\u03c3\u03c6\u03bf\u03c1\u03c5\u03bb\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf. \u039c\u03b5 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b5\u03bd\u03b5\u03c1\u03b3\u03cc STAT3, \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03c4\u03b1\u03b9 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf ROR\u03b3t \u03ba\u03b1\u03b9 IL-17 \u03ba\u03b1\u03b9, \u03b5\u03c0\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2, \u03c4\u03b1 Th17 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b4\u03b5\u03bd \u03b5\u03c0\u03b5\u03ba\u03c4\u03b5\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03cc\u03c3\u03bf \u03b5\u03c0\u03b9\u03b8\u03b5\u03c4\u03b9\u03ba\u03ac. \u0391\u03c5\u03c4\u03cc \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae IL-17, \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b4\u03b9\u03ad\u03b3\u03b5\u03c1\u03c3\u03b7 \u03c4\u03bf\u03c5 FLS \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae IL-6, - \u03ba\u03b1\u03b9 \u03bf \u03b2\u03c1\u03cc\u03c7\u03bf\u03c2 \u03b4\u03b9\u03b1\u03ba\u03cc\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03b5 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03bf\u03cd\u03c2 \u03cc\u03c1\u03bf\u03c5\u03c2, \u03c4\u03bf \u03b2\u03bb\u03ad\u03c0\u03bf\u03c5\u03bc\u03b5 \u03b1\u03c5\u03c4\u03cc \u03c9\u03c2 <strong>\u039c\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd IFN-\u03b3<\/strong> (\u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 Th1, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c1\u03c5\u03b8\u03bc\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03c4\u03b7\u03bd IFN \u03c4\u03cd\u03c0\u03bf\u03c5 \u0399), <strong>\u039c\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd IL-6 <\/strong>(\u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03b1\u03bd\u03b1\u03c4\u03c1\u03bf\u03c6\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 IL-6) \u03ba\u03b1\u03b9 <strong>\u039c\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd IL-17<\/strong> (\u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2 \u03b3\u03b9\u03b1 Th17). \u0391\u03c5\u03c4\u03cc \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03c0\u03b9\u03bf \u03b1\u03c1\u03b3\u03ac \u03b1\u03c0\u03cc \u03cc,\u03c4\u03b9 \u03b7 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03bf\u03c5 NF-\u03baB (\u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03c7\u03ce\u03c1\u03b1 \u03b5\u03bd\u03c4\u03cc\u03c2 \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd) - \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 2-4 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03c5\u03bb\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd \u03c0\u03bb\u03ae\u03c1\u03c9\u03c2 \u03bf\u03b9 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03b1 miRNA, \u03b1\u03bb\u03bb\u03ac \u03cc\u03c4\u03b1\u03bd \u03c5\u03bb\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd, \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03b4\u03b9\u03b1\u03c1\u03ba\u03b5\u03af\u03c2.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Vergleich_JAK1i_wie_Upadacitinib_vs_Huaier\"><\/span><br><strong>\u03a3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7: JAK1i (\u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf upadacitinib) \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03bf\u03c5 Huaier:<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">A <strong>\u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1\u03c2 JAK1<\/strong> \u03cc\u03c0\u03c9\u03c2 <em>Upadacitinib<\/em> (\u03b5\u03bc\u03c0\u03bf\u03c1\u03b9\u03ba\u03ae \u03bf\u03bd\u03bf\u03bc\u03b1\u03c3\u03af\u03b1 Rinvoq) \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03bc\u03b5 \u03b5\u03bd\u03c4\u03b5\u03bb\u03ce\u03c2 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03cc \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u03b1\u03c0\u03cc \u03c4\u03bf Huaier, \u03c0\u03b1\u03c1\u03cc\u03bb\u03bf \u03c0\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b4\u03cd\u03bf \u03c4\u03b5\u03bb\u03b9\u03ba\u03ac \u03b4\u03b9\u03b1\u03bc\u03bf\u03c1\u03c6\u03ce\u03bd\u03bf\u03c5\u03bd \u03c4\u03b9\u03c2 \u03bf\u03b4\u03bf\u03cd\u03c2 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7\u03c2 JAK\/STAT. \u03a4\u03bf upadacitinib \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03bc\u03b9\u03ba\u03c1\u03cc \u03bc\u03cc\u03c1\u03b9\u03bf \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ac\u03bc\u03b5\u03c3\u03b1 <em>\u0398\u03ae\u03ba\u03b7 \u03b4\u03ad\u03c3\u03bc\u03b5\u03c5\u03c3\u03b7\u03c2 \u0391\u03a4\u03a1<\/em> \u03c4\u03bf <em>JAK1 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7<\/em> \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5\u03c2 \u03bc\u03c0\u03bb\u03bf\u03ba\u03ac\u03c1\u03b5\u03b9 \u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac. \u03a0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03ad\u03bd\u03b1 \u03b5\u03af\u03b4\u03bf\u03c2 \u201e\u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03ba\u03bf\u03cd \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1\u201c.<br>\u038c\u03c4\u03b1\u03bd \u03b7 JAK1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03c0\u03bb\u03bf\u03ba\u03b1\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7, \u03b4\u03b5\u03bd \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03c0\u03bb\u03ad\u03bf\u03bd \u03bd\u03b1 \u03c6\u03c9\u03c3\u03c6\u03bf\u03c1\u03c5\u03bb\u03b9\u03ce\u03c3\u03b5\u03b9 \u03c4\u03bf \u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03cd \u03c4\u03c5\u03c1\u03bf\u03c3\u03af\u03bd\u03b7 \u03c3\u03c4\u03b9\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 STAT, \u03b1\u03bd\u03b5\u03be\u03ac\u03c1\u03c4\u03b7\u03c4\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c0\u03cc\u03c3\u03bf \u03c3\u03ba\u03bb\u03b7\u03c1\u03ac \u03c0\u03c1\u03bf\u03c3\u03c0\u03b1\u03b8\u03b5\u03af \u03bf \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2 \u03bd\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd JAK. \u03a4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b3\u03c1\u03ae\u03b3\u03bf\u03c1\u03bf: \u03bc\u03cc\u03bb\u03b9\u03c2 \u03b7 upadacitinib \u03b1\u03c0\u03bf\u03c1\u03c1\u03bf\u03c6\u03b7\u03b8\u03b5\u03af \u03c3\u03c4\u03b7\u03bd \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1 \u03c4\u03bf\u03c5 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c6\u03c4\u03ac\u03c3\u03b5\u03b9 \u03c3\u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03b7 JAK1 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03c4\u03b1\u03b9. \u0391\u03c5\u03c4\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03bb\u03cc\u03b3\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03bf\u03c0\u03bf\u03af\u03bf \u03bf\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 JAK \u03ad\u03c7\u03bf\u03c5\u03bd \u03c4\u03b1\u03c7\u03b5\u03af\u03b1 \u03ad\u03bd\u03b1\u03c1\u03be\u03b7, \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 2-4 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03bc\u03ad\u03c7\u03c1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03b9\u03c3\u03b8\u03b7\u03c4\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b1\u03c5\u03c4\u03cc\u03c2 \u03bf \u03ac\u03bc\u03b5\u03c3\u03bf\u03c2 \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03bc\u03cc\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bc\u03b5\u03b9\u03bf\u03bd\u03b5\u03ba\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1. \u039f\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 JAK1 \u03b4\u03b5\u03bd \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bd \u03bc\u03cc\u03bd\u03bf \u03c4\u03b7\u03bd JAK1, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b5\u03c2 JAK \u03c3\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03cc \u03b2\u03b1\u03b8\u03bc\u03cc, \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03ac \u03c4\u03bf\u03c5\u03c2. \u0391\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u201e\u03b5\u03c0\u03b9\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03bf\u03af\u201c \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 JAK1 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03ba\u03ac\u03c0\u03bf\u03b9\u03bf \u03b2\u03b1\u03b8\u03bc\u03cc \u03c4\u03b9\u03c2 JAK2 \u03ba\u03b1\u03b9 TYK2. \u0391\u03c5\u03c4\u03cc \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 <strong>\u03a0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/strong>, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03b3\u03b9\u03b1 <strong>\u0388\u03c1\u03c0\u03b7\u03c2 \u03b6\u03c9\u03c3\u03c4\u03ae\u03c1\u03b1\u03c2<\/strong> (\u03ad\u03c1\u03c0\u03b7\u03c4\u03b1\u03c2 \u03b6\u03c9\u03c3\u03c4\u03ae\u03c1\u03b1\u03c2), \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03bf \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c4\u03b7\u03c2 JAK3 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc \u03c4\u03c9\u03bd \u03a4-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c0\u03ce\u03c2 \u03c4\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03c4\u03c9\u03bd \u03bb\u03b1\u03bd\u03b8\u03b1\u03bd\u03cc\u03bd\u03c4\u03c9\u03bd \u03b9\u03ce\u03bd, \u03cc\u03c0\u03c9\u03c2 \u03bf\u03b9 <em>Varicella zoster<\/em> \u03b1\u03c0\u03bf\u03b4\u03c5\u03bd\u03b1\u03bc\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9. \u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ac, \u03bf \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c4\u03b7\u03c2 JAK2 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 <strong>\u0395\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03b5\u03bc\u03b2\u03bf\u03bb\u03ae\u03c2<\/strong> \u03b1\u03bd\u03c4\u03af \u03c4\u03b7\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 (\u03b9\u03b4\u03af\u03c9\u03c2 \u03c4\u03b7\u03c2 baricitinib, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03c4\u03b7\u03bd JAK2 \u03c0\u03b9\u03bf \u03b9\u03c3\u03c7\u03c5\u03c1\u03ac).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Huaier<\/strong> \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03c3\u03b5 \u03b5\u03bd\u03c4\u03b5\u03bb\u03ce\u03c2 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03cc \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf. \u0394\u03b5\u03bd \u03bc\u03c0\u03bb\u03bf\u03ba\u03ac\u03c1\u03b5\u03b9 \u03ac\u03bc\u03b5\u03c3\u03b1 \u03c4\u03b7\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 JAK. \u0391\u03bd\u03c4' \u03b1\u03c5\u03c4\u03bf\u03cd <strong>\u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf<\/strong> it <strong>\u03c4\u03b7\u03bd \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 JAK<\/strong>, \u03cc\u03c4\u03b9 \u03c4\u03bf \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03b9 \u03ba\u03b1\u03b8\u03cc\u03bb\u03bf\u03c5. \u0391\u03c5\u03c4\u03cc \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03b9\u03ba\u03bf\u03b4\u03cc\u03bc\u03b7\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 mRNA \u03c4\u03b7\u03c2 JAK \u03bc\u03b5 \u03c4\u03b7 \u03bc\u03b5\u03c3\u03bf\u03bb\u03ac\u03b2\u03b7\u03c3\u03b7 miRNA. \u03a4\u03bf \u03c0\u03bb\u03b5\u03bf\u03bd\u03ad\u03ba\u03c4\u03b7\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b1\u03c5\u03c4\u03cc\u03c2 \u03bf \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03bb\u03b5\u03c0\u03c4\u03cc\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03bd\u03b4\u03b5\u03c7\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03c0\u03b9\u03bf \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc\u03c2. \u03a4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b1\u03c0\u03bb\u03ce\u03c2 \u03c1\u03c5\u03b8\u03bc\u03af\u03b6\u03bf\u03c5\u03bd \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b1 \u03ba\u03ac\u03c4\u03c9 \u03c4\u03bf \u03c0\u03cc\u03c3\u03bf JAK \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03c5\u03bd \u03b1\u03bd\u03c4\u03af \u03b3\u03b9\u03b1 \u03ad\u03bd\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bb\u03bf\u03ba\u03ac\u03c1\u03b5\u03b9 \u03b2\u03af\u03b1\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7. \u03a4\u03bf \u03bc\u03b5\u03b9\u03bf\u03bd\u03ad\u03ba\u03c4\u03b7\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b1\u03c5\u03c4\u03ae \u03b7 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03b1\u03c1\u03b3\u03ae. \u03a7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c1\u03ba\u03b5\u03c4\u03ad\u03c2 \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2 \u03ad\u03c9\u03c2 \u03bc\u03af\u03b1 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b1 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03bf\u03cd\u03bd \u03c4\u03b1 miRNAs \u03c3\u03b5 \u03b5\u03c0\u03b1\u03c1\u03ba\u03b5\u03af\u03c2 \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c1\u03ba\u03b5\u03c4\u03ad\u03c2 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03b9\u03ba\u03bf\u03b4\u03bf\u03bc\u03b7\u03b8\u03b5\u03af \u03b1\u03c1\u03ba\u03b5\u03c4\u03cc JAK mRNA \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03bc\u03b5\u03b9\u03c9\u03b8\u03bf\u03cd\u03bd \u03b1\u03b9\u03c3\u03b8\u03b7\u03c4\u03ac \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 JAK. \u0391\u03c5\u03c4\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03bb\u03cc\u03b3\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03bf\u03c0\u03bf\u03af\u03bf \u03b7 Huaier \u03ad\u03c7\u03b5\u03b9 \u03c0\u03b9\u03bf \u03b1\u03c1\u03b3\u03ae \u03ad\u03bd\u03b1\u03c1\u03be\u03b7, \u03c0\u03b9\u03b8\u03b1\u03bd\u03ce\u03c2 4-8 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03bc\u03ad\u03c7\u03c1\u03b9 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b7\u03b8\u03bf\u03cd\u03bd \u03b1\u03be\u03b9\u03bf\u03c3\u03b7\u03bc\u03b5\u03af\u03c9\u03c4\u03b5\u03c2 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03b9\u03c2 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03be\u03b1\u03c1\u03c4\u03ce\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd JAK\/STAT.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039c\u03b9\u03b1 \u03ac\u03bb\u03bb\u03b7 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03c1\u03b5\u03c8\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1. \u038c\u03c4\u03b1\u03bd \u03ad\u03bd\u03b1\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03b4\u03b9\u03b1\u03ba\u03cc\u03c0\u03c4\u03b5\u03b9 \u03c4\u03b7 \u03bb\u03ae\u03c8\u03b7 \u03c4\u03b7\u03c2 upadacitinib, \u03bf \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c4\u03b7\u03c2 JAK \u03bf\u03bb\u03bf\u03ba\u03bb\u03b7\u03c1\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b5\u03bd\u03c4\u03cc\u03c2 24-48 \u03c9\u03c1\u03ce\u03bd, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03bf \u03c7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03b7\u03bc\u03b9\u03b6\u03c9\u03ae\u03c2 \u03c4\u03b7\u03c2 upadacitinib \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03ba\u03c1\u03cc\u03c2. \u0397 JAK1 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c0\u03ac\u03bb\u03b9 \u03b5\u03bd\u03b5\u03c1\u03b3\u03ae \u03ba\u03b1\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c6\u03c9\u03c3\u03c6\u03bf\u03c1\u03c5\u03bb\u03b9\u03ce\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd STAT. \u0391\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03bf \u03b5\u03ac\u03bd \u03ad\u03bd\u03b1\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03c0\u03ac\u03c3\u03c7\u03b5\u03b9 \u03b1\u03c0\u03cc \u03bb\u03bf\u03b9\u03bc\u03ce\u03be\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03ba\u03cc\u03c8\u03b5\u03b9 \u03c4\u03b7 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae, \u03b1\u03bb\u03bb\u03ac \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03cc\u03c4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b7 \u03b7 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ae \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae \u03bb\u03ae\u03c8\u03b7. \u03a4\u03bf Huaier \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7\u03c2 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03b7 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03bf miRNA \u03b4\u03b9\u03b1\u03c1\u03ba\u03b5\u03af \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf. \u03a4\u03b1 \u03af\u03b4\u03b9\u03b1 \u03c4\u03b1 miRNA \u03ad\u03c7\u03bf\u03c5\u03bd \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03c7\u03c1\u03cc\u03bd\u03bf \u03b7\u03bc\u03b9\u03b6\u03c9\u03ae\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03bc\u03b9\u03ba\u03c1\u03ac \u03bc\u03cc\u03c1\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03b7 \u03b1\u03bd\u03ac\u03ba\u03c4\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 JAK \u03b4\u03b9\u03b1\u03c1\u03ba\u03b5\u03af \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03cc\u03c4\u03b1\u03bd \u03b7 \u03ad\u03ba\u03b8\u03b5\u03c3\u03b7 \u03c3\u03c4\u03bf Huaier \u03c3\u03c4\u03b1\u03bc\u03b1\u03c4\u03ac.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039c\u03b9\u03b1 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03c0\u03b9\u03bf \u03bb\u03b5\u03c0\u03c4\u03ae \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac \u03ad\u03b3\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03be\u03b5\u03b9\u03b4\u03af\u03ba\u03b5\u03c5\u03c3\u03b7. \u0397 upadacitinib \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03b9\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03c9\u03c2 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b7\u03bd JAK1, \u03c0\u03c1\u03ac\u03b3\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03b6\u03b5\u03b9 \u03ad\u03bd\u03c4\u03bf\u03bd\u03b1 \u03c4\u03b7\u03bd JAK1, \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03c2 \u03c4\u03b7\u03bd JAK2 \u03ba\u03b1\u03b9 \u03b5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03b1 \u03c4\u03b7\u03bd JAK3. \u0391\u03c5\u03c4\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bf \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03b7\u03c2 JAK1, \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03b7 \u03b1\u03c0\u03bf\u03c6\u03c5\u03b3\u03ae \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03bc\u03bf\u03cd \u03c4\u03b7\u03c2 JAK3 \u03c0\u03c1\u03bf\u03ba\u03b5\u03b9\u03bc\u03ad\u03bd\u03bf\u03c5 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03b7\u03b8\u03bf\u03cd\u03bd \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b1 \u03bf\u03b9 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b5\u03c2 \u03c4\u03c9\u03bd \u03a4-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd.<br>\u03a4\u03bf Huaier \u03c0\u03b9\u03b8\u03b1\u03bd\u03ce\u03c2 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd JAK1, \u03c4\u03b7\u03bd JAK2 \u03ba\u03b1\u03b9 \u03b5\u03bd\u03b4\u03b5\u03c7\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03c4\u03b7\u03bd TYK2 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03ae \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b1\u03bd\u03b1\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac, \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03c0\u03bf\u03b9\u03b1 miRNAs \u03c1\u03c5\u03b8\u03bc\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9. \u0391\u03c5\u03c4\u03cc \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03bd\u03b1 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b7 Huaier \u03ad\u03c7\u03b5\u03b9 <strong>\u03b5\u03c5\u03c1\u03cd\u03c4\u03b5\u03c1\u03b7 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 JAK<\/strong> \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03bb\u03cc \u03b3\u03b9\u03b1 \u03c0\u03c1\u03ac\u03b3\u03bc\u03b1\u03c4\u03b1 \u03cc\u03c0\u03c9\u03c2 \u03b7 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 IFN \u03c4\u03cd\u03c0\u03bf\u03c5 \u0399 (\u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c4\u03b7\u03bd TYK2), \u03b1\u03bb\u03bb\u03ac \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b4\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c4\u03b7\u03c2 JAK2 (\u03b8\u03b5\u03c9\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03b5\u03bc\u03b2\u03bf\u03bb\u03ae\u03c2).<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"PI3KAKT-Aktivierung_Mitochondriale_Restoration_Treg-Support\"><\/span>\u0395\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 PI3K\/AKT (\u03bc\u03b9\u03c4\u03bf\u03c7\u03bf\u03bd\u03b4\u03c1\u03b9\u03b1\u03ba\u03ae \u03b1\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 + \u03c5\u03c0\u03bf\u03c3\u03c4\u03ae\u03c1\u03b9\u03be\u03b7 Treg)<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u0388\u03bd\u03b1 \u03c4\u03c1\u03af\u03c4\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03c0\u03c1\u03cc\u03b2\u03bb\u03b7\u03bc\u03b1 \u03c4\u03b7\u03c2 ARLA \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b7 \u03b5\u03c0\u03af\u03bc\u03bf\u03bd\u03b7 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c0\u03c1\u03bf\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03c9\u03b4\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03b7 \u03ba\u03b1\u03c4\u03ac\u03c1\u03c1\u03b5\u03c5\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd \u03c0\u03bf\u03c5 \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03ac \u03b8\u03b1 \u03c0\u03b5\u03c1\u03b9\u03cc\u03c1\u03b9\u03b6\u03b1\u03bd \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae. \u03a4\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03bf \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03b5\u03bb\u03ad\u03b3\u03c7\u03b5\u03b9 \u03c4\u03b7 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc\u03c2 \u03c4\u03c9\u03bd \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03a4 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (<em>Tregs<\/em>), \u03b9\u03b4\u03af\u03c9\u03c2 <em>CD4+CD25+Foxp3+ <\/em>Tregs.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03c4\u03bf\u03c5\u03c2 \u03c5\u03b3\u03b9\u03b5\u03af\u03c2 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2, \u03c4\u03b1 Tregs \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03b1\u03bd\u03b1\u03c0\u03cc\u03c3\u03c0\u03b1\u03c3\u03c4\u03bf \u03bc\u03ad\u03c1\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03c1\u03bf\u03c5\u03bd \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03c9\u03b4\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd \u03cc\u03c0\u03c9\u03c2 \u03bf\u03b9 <em>IL-10<\/em> \u03ba\u03b1\u03b9 <em>TGF-\u03b2<\/em>, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03ac\u03bc\u03b5\u03c3\u03b7\u03c2 \u03b5\u03c0\u03b1\u03c6\u03ae\u03c2 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03bf\u03c5 \u03bc\u03b5 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf, \u03c0\u03c1\u03bf\u03ba\u03b5\u03b9\u03bc\u03ad\u03bd\u03bf\u03c5 \u03bd\u03b1 \u03b5\u03c0\u03ac\u03b3\u03bf\u03c5\u03bd \u03c0\u03c1\u03bf\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7 \u03a4-\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 (<em>\u039a\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03a4-\u03c6\u03bf\u03c1\u03ad\u03b1<\/em>) \u03c0\u03bf\u03c5 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03b1\u03c6\u03bf\u03cd\u03bd.<br>\u03a4\u03b1 Tregs \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ac \u03c0\u03bf\u03bb\u03cd \u03b5\u03bd\u03b5\u03c1\u03b3\u03ac \u03ba\u03b1\u03b9 \u03b2\u03b1\u03c3\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03bf\u03be\u03b5\u03b9\u03b4\u03c9\u03c4\u03b9\u03ba\u03ae \u03c6\u03c9\u03c3\u03c6\u03bf\u03c1\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd <em>\u039c\u03b9\u03c4\u03bf\u03c7\u03cc\u03bd\u03b4\u03c1\u03b9\u03b1<\/em> \u0391\u03c5\u03c4\u03cc \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ac \u03bc\u03b9\u03c4\u03bf\u03c7\u03cc\u03bd\u03b4\u03c1\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c7\u03ae \u03c0\u03b1\u03c1\u03bf\u03c7\u03ae <em>ATP<\/em>. \u03a7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c4\u03b7\u03bd \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bd\u03b1 \u03c3\u03c5\u03bd\u03b8\u03ad\u03c4\u03bf\u03c5\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2, \u03b9\u03b4\u03af\u03c9\u03c2 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03c5\u03bd \u03c4\u03bf <em>\u03a1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae <\/em>\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 Foxp3 \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ad\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03af\u03bd\u03b5\u03c2 IL-10 \u03ba\u03b1\u03b9 TGF-\u03b2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a0\u03bf\u03bb\u03bb\u03ac \u03c0\u03c1\u03ac\u03b3\u03bc\u03b1\u03c4\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03ac\u03b5\u03b9 \u03c3\u03c4\u03c1\u03b1\u03b2\u03ac \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 ARLA. \u03a0\u03c1\u03ce\u03c4\u03bf\u03bd, \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03c3\u03c5\u03bd\u03b5\u03c7\u03bf\u03cd\u03c2 \u03b4\u03b9\u03ad\u03b3\u03b5\u03c1\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd TLR2 \u03ba\u03b1\u03b9 TLR7\/8, \u03b7 <strong>\u039c\u03b9\u03c4\u03bf\u03c7\u03cc\u03bd\u03b4\u03c1\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03ba\u03b1\u03c4\u03b1\u03c0\u03bf\u03bd\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c7\u03c1\u03bf\u03bd\u03af\u03c9\u03c2<\/strong>. \u0397 \u03c3\u03c5\u03bd\u03b5\u03c7\u03ae\u03c2 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae <em>ROS<\/em> (\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ad\u03c2 \u03bf\u03be\u03c5\u03b3\u03cc\u03bd\u03bf\u03c5) \u03b1\u03c0\u03cc \u03c4\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b1 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bf\u03be\u03b5\u03b9\u03b4\u03ce\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b5\u03c3\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03ae \u03bc\u03b9\u03c4\u03bf\u03c7\u03bf\u03bd\u03b4\u03c1\u03b9\u03b1\u03ba\u03ae \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03ad\u03c6\u03bf\u03c5\u03bd \u03c4\u03b1 \u03c3\u03cd\u03bc\u03c0\u03bb\u03bf\u03ba\u03b1 \u03c4\u03b7\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b1\u03c2 \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03bd\u03af\u03c9\u03bd. \u03a4\u03bf \u03bc\u03b9\u03c4\u03bf\u03c7\u03bf\u03bd\u03b4\u03c1\u03b9\u03b1\u03ba\u03cc DNA \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bf\u03be\u03b5\u03b9\u03b4\u03c9\u03b8\u03b5\u03af, \u03bf\u03b4\u03b7\u03b3\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c3\u03b5 \u03b5\u03bb\u03b1\u03c4\u03c4\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae. \u03a4\u03b1 \u03bc\u03b9\u03c4\u03bf\u03c7\u03cc\u03bd\u03b4\u03c1\u03b9\u03b1 \u03b1\u03c0\u03bb\u03ac \u03b4\u03b5\u03bd \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03c5\u03bd \u03b1\u03c1\u03ba\u03b5\u03c4\u03cc \u0391\u03a4\u03a1 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03c4\u03c1\u03bf\u03c6\u03bf\u03b4\u03bf\u03c4\u03ae\u03c3\u03bf\u03c5\u03bd \u03cc\u03bb\u03b1 \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7 \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0394\u03b5\u03cd\u03c4\u03b5\u03c1\u03bf\u03bd, \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 <strong>\u03c7\u03c1\u03cc\u03bd\u03b9\u03bf <em>\u039a\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c3\u03c4\u03c1\u03b5\u03c2 ER<\/em><\/strong> (\u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03c4\u03b1 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03c5\u03bd \u03c3\u03c5\u03bd\u03b5\u03c7\u03ce\u03c2 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b5\u03c2 \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b7 <em>\u0399\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03bd\u03b1\u03b4\u03af\u03c0\u03bb\u03c9\u03c3\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd<\/em> \u03c4\u03bf\u03c5 <em>\u03b5\u03bd\u03b4\u03bf\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03b4\u03af\u03ba\u03c4\u03c5\u03bf<\/em> \u03ad\u03c7\u03b5\u03b9 \u03ba\u03b1\u03c4\u03b1\u03ba\u03bb\u03c5\u03c3\u03c4\u03b5\u03af), \u03c4\u03bf <em>\u0399\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd<\/em> \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ac.<br>\u03a4\u03b1 \u03c1\u03b9\u03b2\u03bf\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03b5\u03c1\u03b3\u03b1\u03bb\u03b5\u03af\u03bf \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03c4\u03bf ER \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c5\u03c0\u03cc \u03c0\u03af\u03b5\u03c3\u03b7, \u03c4\u03b1 \u03c1\u03b9\u03b2\u03bf\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b2\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c5\u03c0\u03cc \u03c0\u03af\u03b5\u03c3\u03b7. \u03a9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1, \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03b7 Foxp3, \u03b7 IL-10 \u03ba\u03b1\u03b9 \u03bf TGF-\u03b2 \u03b4\u03b5\u03bd \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c7\u03b8\u03bf\u03cd\u03bd \u03b2\u03ad\u03bb\u03c4\u03b9\u03c3\u03c4\u03b1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03c1\u03af\u03c4\u03bf\u03bd, \u03bc\u03ad\u03c3\u03b1 \u03b1\u03c0\u03cc \u03cc\u03bb\u03b1 \u03b1\u03c5\u03c4\u03ac \u03c4\u03b1 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ac \u03c0\u03c1\u03bf\u03b2\u03bb\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 <strong>Tregs<\/strong> \u03b1\u03c0\u03bb\u03cc <strong>\u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03cc<\/strong>. \u0391\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b1 Tregs \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03b1\u03ba\u03cc\u03bc\u03b7 \u03bd\u03b1 \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03c5\u03b8\u03bf\u03cd\u03bd (\u03c3\u03c5\u03c7\u03bd\u03ac \u03bc\u03ac\u03bb\u03b9\u03c3\u03c4\u03b1 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc), \u03b7 \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03ac \u03c4\u03bf\u03c5\u03c2 \u03bd\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac. \u0394\u03b5\u03bd \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03c5\u03bd \u03b1\u03c1\u03ba\u03b5\u03c4\u03ae IL-10. \u03a3\u03c5\u03bd\u03b5\u03c0\u03ce\u03c2, \u03c4\u03b1 Tregs \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b5 \u03b8\u03ad\u03c3\u03b7 \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b5\u03af\u03bb\u03bf\u03c5\u03bd \u03b5\u03c0\u03b1\u03c1\u03ba\u03ce\u03c2 \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 Th17 \u03ba\u03b1\u03b9 Th1. \u039c\u03b5 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03b7 IL-10 \u03c3\u03c4\u03bf \u03c0\u03b5\u03c1\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd, \u03c4\u03bf \u03b1\u03bd\u03c4\u03b9\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b5\u03c2 \u201e\u03c6\u03c1\u03b5\u03bd\u03ac\u03c1\u03b9\u03c3\u03bc\u03b1\u201c \u03c4\u03bf\u03c5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b4\u03b5\u03bd \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bb\u03ac\u03b2\u03b5\u03b9 \u03c7\u03ce\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03bf <strong>\u0397 \u03c0\u03c1\u03bf\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7\u03c2 \u201e\u03b5\u03c0\u03b9\u03c4\u03ac\u03c7\u03c5\u03bd\u03c3\u03b7\u201c \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a0\u03ce\u03c2 \u03bf Huaier \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\/\u03b5\u03c0\u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b5\u03b9 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f Huaier \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03c9\u03c0\u03af\u03b6\u03b5\u03b9 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03c0\u03c1\u03cc\u03b2\u03bb\u03b7\u03bc\u03b1 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03bf\u03c5 <em>\u039c\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7\u03c2 PI3K\/AKT<\/em> on. \u038c\u03c4\u03b1\u03bd \u03bf\u03b9 \u03c0\u03bf\u03bb\u03c5\u03c3\u03b1\u03ba\u03c7\u03b1\u03c1\u03af\u03c4\u03b5\u03c2 Huaier \u03c3\u03c5\u03bd\u03b4\u03ad\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 Dectin-1, \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c4\u03b1 \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9\u03b1 NF-\u03ba\u0392 \u03ba\u03b1\u03b9 \u03b9\u03bd\u03c4\u03b5\u03c1\u03c6\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd PI3K (\u03c6\u03c9\u03c3\u03c6\u03bf\u03ca\u03bd\u03bf\u03c3\u03b9\u03c4\u03b9\u03b4\u03b9\u03ba\u03ae 3-\u03ba\u03b9\u03bd\u03ac\u03c3\u03b7). \u0397 PI3K \u03ba\u03b1\u03c4\u03b1\u03bb\u03cd\u03b5\u03b9 \u03c4\u03b7 \u03c6\u03c9\u03c3\u03c6\u03bf\u03c1\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c6\u03c9\u03c3\u03c6\u03b1\u03c4\u03b9\u03b4\u03c5\u03bb\u03b9\u03bd\u03bf\u03c3\u03b9\u03c4\u03cc\u03bb\u03b7\u03c2-(4,5)-\u03b4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03c1\u03b9\u03ba\u03ae\u03c2 (<em>PIP2<\/em>) \u03c3\u03b5 \u03c6\u03c9\u03c3\u03c6\u03b1\u03c4\u03b9\u03b4\u03c5\u03bb\u03b9\u03bd\u03bf\u03c3\u03b9\u03c4\u03cc\u03bb\u03b7-(3,4,5)-\u03c4\u03c1\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03c1\u03b9\u03ba\u03ae (<em>PIP3<\/em>). \u03a4\u03bf PIP3 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u201e\u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03bf\u03c2 \u03b1\u03b3\u03b3\u03b5\u03bb\u03b9\u03bf\u03c6\u03cc\u03c1\u03bf\u03c2\u201c - \u03ad\u03bd\u03b1 \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc \u03bc\u03cc\u03c1\u03b9\u03bf \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c3\u03b5\u03bb\u03ba\u03cd\u03b5\u03b9 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c3\u03b5\u03bb\u03ba\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd PIP3 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 <em>ACT<\/em> (\u03c0\u03bf\u03c5 \u03bf\u03bd\u03bf\u03bc\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b9\u03ba\u03ae \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7 \u0392). \u0397 AKT \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b5\u03be\u03b1\u03c1\u03c4\u03ce\u03bc\u03b5\u03bd\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf 3-\u03c6\u03c9\u03c3\u03c6\u03bf\u03ca\u03bd\u03bf\u03c3\u03b9\u03c4\u03af\u03b4\u03b9\u03bf \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b9\u03ba\u03ae \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7 1 (<em>PDK1<\/em>) \u03c6\u03c9\u03c3\u03c6\u03bf\u03c1\u03c5\u03bb\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9. \u039c\u03cc\u03bb\u03b9\u03c2 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af, \u03b7 AKT \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u201e\u03ba\u03cd\u03c1\u03b9\u03bf\u03c2 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03ae\u03c2\u201c \u03c0\u03bf\u03bb\u03bb\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ce\u03bd \u03b4\u03b9\u03b5\u03c1\u03b3\u03b1\u03c3\u03b9\u03ce\u03bd. \u03a3\u03c4\u03bf \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf \u03c4\u03b7\u03c2 ARLA, \u03b4\u03cd\u03bf \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b5\u03c2 \u03c4\u03b7\u03c2 AKT \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a0\u03c1\u03ce\u03c4\u03bf\u03bd, <strong>\u03a4\u03bf AKT \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03bf mTOR<\/strong> (mechanistic Target Of Rapamycin), \u03ad\u03bd\u03b1 \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b9\u03ba\u03cc \u03c3\u03cd\u03bc\u03c0\u03bb\u03b5\u03b3\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03b5\u03bb\u03ad\u03b3\u03c7\u03b5\u03b9 \u03c4\u03b7 \u03bc\u03b5\u03c4\u03ac\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 mRNA \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03b2\u03b9\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c1\u03b9\u03b2\u03bf\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd.<br>\u038c\u03c4\u03b1\u03bd \u03c4\u03bf AKT \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03bf mTOR, \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03bf\u03c5\u03bd \u03b4\u03cd\u03bf \u03c0\u03c1\u03ac\u03b3\u03bc\u03b1\u03c4\u03b1: (1) \u03c4\u03bf mTOR \u03c6\u03c9\u03c3\u03c6\u03bf\u03c1\u03c5\u03bb\u03b9\u03ce\u03bd\u03b5\u03b9 <em>S6K<\/em> (\u03c1\u03b9\u03b2\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03ae S6 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7), \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c6\u03c9\u03c3\u03c6\u03bf\u03c1\u03c5\u03bb\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b9\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 S6 \u03c3\u03c4\u03b1 \u03c1\u03b9\u03b2\u03bf\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1, \u03bf\u03b4\u03b7\u03b3\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c3\u03b5 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2. (2) \u0397 mTOR \u03c6\u03c9\u03c3\u03c6\u03bf\u03c1\u03c5\u03bb\u03b9\u03ce\u03bd\u03b5\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 <em>4E-BP1<\/em> (4E-Binding Protein 1), \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03ad\u03c3\u03bc\u03b5\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 4E-BP1 \u03c3\u03b5 <em>eIF4E<\/em> \u03ba\u03b1\u03b9, \u03c9\u03c2 \u03b5\u03ba \u03c4\u03bf\u03cd\u03c4\u03bf\u03c5, \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03bc\u03b5\u03c4\u03ac\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd mRNA \u03c0\u03bf\u03c5 \u03b5\u03be\u03b1\u03c1\u03c4\u03ce\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd eIF4E.<br>\u03a4\u03bf \u03ba\u03b1\u03b8\u03b1\u03c1\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03bf \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03c3\u03b5 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c7\u03c1\u03cc\u03bd\u03bf. \u0393\u03b9\u03b1 \u03c4\u03bf <strong>Tregs<\/strong> \u03b1\u03c5\u03c4\u03cc \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03c0\u03bb\u03ad\u03bf\u03bd \u03bd\u03b1 <strong>\u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03c5\u03bd \u03b2\u03ad\u03bb\u03c4\u03b9\u03c3\u03c4\u03b1 IL-10 \u03ba\u03b1\u03b9 Foxp3<\/strong>, \u03c4\u03b9\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9, <strong>\u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0394\u03b5\u03cd\u03c4\u03b5\u03c1\u03bf\u03bd, <strong>\u03a4\u03bf AKT \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b7 \u03b2\u03b9\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7 \u03bd\u03ad\u03c9\u03bd \u03bc\u03b9\u03c4\u03bf\u03c7\u03bf\u03bd\u03b4\u03c1\u03af\u03c9\u03bd<\/strong>. \u0391\u03c5\u03c4\u03cc \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03c4\u03b1\u03b9 \u03b5\u03bd \u03bc\u03ad\u03c1\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 PGC1\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd AKT.<br>\u0397 PGC1\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03bb\u03b5\u03b3\u03cc\u03bc\u03b5\u03bd\u03bf\u03c2 \u201e\u03ba\u03cd\u03c1\u03b9\u03bf\u03c2 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03ae\u03c2\u201c \u03c4\u03b7\u03c2 \u03bc\u03b9\u03c4\u03bf\u03c7\u03bf\u03bd\u03b4\u03c1\u03b9\u03b1\u03ba\u03ae\u03c2 \u03b2\u03b9\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2. \u0395\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03c3\u03c5\u03bd\u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03ae\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b5\u03c1\u03b3\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03bf\u03c5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd \u03c0\u03bf\u03c5 \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03bc\u03b9\u03c4\u03bf\u03c7\u03bf\u03bd\u03b4\u03c1\u03b9\u03b1\u03ba\u03ad\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2. <br>\u039c\u03b5 \u03b5\u03bd\u03b5\u03c1\u03b3\u03cc <em>PGC1\u03b1<\/em> \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bd\u03ad\u03b1 \u03bc\u03b9\u03c4\u03bf\u03c7\u03cc\u03bd\u03b4\u03c1\u03b9\u03b1 \u03c3\u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1. \u03a3\u03b5 \u03b4\u03b9\u03ac\u03c3\u03c4\u03b7\u03bc\u03b1 \u03b1\u03c1\u03ba\u03b5\u03c4\u03ce\u03bd \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03c9\u03bd, \u03b1\u03c5\u03c4\u03cc \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03b1 Tregs \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b1\u03bd\u03b1\u03bd\u03b5\u03ce\u03c3\u03bf\u03c5\u03bd \u03c4\u03bf\u03c5\u03c2 \u03bc\u03b9\u03c4\u03bf\u03c7\u03bf\u03bd\u03b4\u03c1\u03b9\u03b1\u03ba\u03bf\u03cd\u03c2 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03bf\u03cd\u03c2 \u03c4\u03bf\u03c5\u03c2, \u03c4\u03b1 \u03c0\u03b1\u03bb\u03b9\u03ac, \u03ba\u03b1\u03c4\u03b5\u03c3\u03c4\u03c1\u03b1\u03bc\u03bc\u03ad\u03bd\u03b1 \u03bc\u03b9\u03c4\u03bf\u03c7\u03cc\u03bd\u03b4\u03c1\u03b9\u03b1 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03b8\u03af\u03c3\u03c4\u03b1\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03bd\u03ad\u03b1, \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03c4\u03b1 <strong>\u03b1\u03c0\u03bf\u03ba\u03b1\u03b8\u03af\u03c3\u03c4\u03b1\u03c4\u03b1\u03b9 \u03b7 \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd Tregs \u03bd\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03c5\u03bd \u0391\u03a4\u03a1<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039c\u03b5 \u03b2\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03bc\u03b9\u03c4\u03bf\u03c7\u03bf\u03bd\u03b4\u03c1\u03b9\u03b1\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd, \u03c4\u03b1 Tregs \u03b1\u03bd\u03b1\u03ba\u03c4\u03bf\u03cd\u03bd \u03c4\u03b7\u03bd \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bd\u03b1 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac. \u039c\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03c5\u03bd \u03be\u03b1\u03bd\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 IL-10. \u039c\u03b5 \u03c4\u03b7\u03bd IL-10 \u03c3\u03c4\u03bf \u03b1\u03c1\u03b8\u03c1\u03b9\u03ba\u03cc \u03c5\u03b3\u03c1\u03cc, \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 Th17 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03bf\u03cd\u03bd, \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 Th1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b1\u03bd\u03b1\u03c3\u03c4\u03b1\u03bb\u03bf\u03cd\u03bd \u03ba\u03b1\u03b9 \u03b7 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b9\u03bb\u03c5\u03b8\u03b5\u03af.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03bc\u03b9\u03b1 \u03b1\u03c1\u03b3\u03ae \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1, \u03b7 \u03b2\u03b9\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bd\u03ad\u03c9\u03bd \u03bc\u03b9\u03c4\u03bf\u03c7\u03bf\u03bd\u03b4\u03c1\u03af\u03c9\u03bd \u03b4\u03b9\u03b1\u03c1\u03ba\u03b5\u03af \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2, \u03b1\u03bb\u03bb\u03ac \u03b5\u03af\u03bd\u03b1\u03b9 \u03b2\u03b9\u03ce\u03c3\u03b9\u03bc\u03b7. \u0395\u03bd\u03ce \u03b7 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03bf\u03c5 NF-\u03baB \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd Huaier \u03ad\u03c7\u03b5\u03b9 \u03c4\u03b1\u03c7\u03b5\u03af\u03b1 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 (\u03b7\u03bc\u03ad\u03c1\u03b5\u03c2) \u03ba\u03b1\u03b9 \u03b7 \u03b4\u03b9\u03b1\u03bc\u03cc\u03c1\u03c6\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 JAK\/STAT \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03c3\u03bf\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03b7 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 (\u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2), \u03b7 <em>\u0395\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 PI3K\/AKT<\/em> \u03bc\u03b9\u03b1 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c0\u03b1\u03c1\u03ad\u03bc\u03b2\u03b1\u03c3\u03b7, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b4\u03b5\u03bd \u03b8\u03b1 \u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9 \u03c4\u03bf \u03b8\u03b5\u03bc\u03b5\u03bb\u03b9\u03ce\u03b4\u03b5\u03c2 <strong>\u03b1\u03c0\u03bf\u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac \u03c4\u03b9\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c5\u03bd\u03b8\u03ae\u03ba\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c7\u03ae<\/strong>.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Spezifische_Effekte_bei_ARLA\"><\/span><br><strong>\u03a3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd ARLA:<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03b5 \u03ad\u03bd\u03b1\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae ARLA \u03c3\u03c4\u03b7 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ae \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 Huaier, \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b1 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac. \u03a0\u03c1\u03ce\u03c4\u03bf\u03bd, \u03c4\u03b1 \u03bc\u03b9\u03c4\u03bf\u03c7\u03cc\u03bd\u03b4\u03c1\u03b9\u03b1 \u03c3\u03c4\u03b1 \u03b1\u03c1\u03b8\u03c1\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03c4\u03b1 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c6\u03ac\u03b3\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03a4 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b4\u03ad\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b5\u03c0\u03af\u03b8\u03b5\u03c3\u03b7. \u0397 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b1 \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03bd\u03af\u03c9\u03bd \u03b4\u03b5\u03bd \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03b2\u03ad\u03bb\u03c4\u03b9\u03c3\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b7 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7 \u0391\u03a4\u03a1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7. \u0391\u03c5\u03c4\u03cc \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03b4\u03b5\u03b9\u03c7\u03b8\u03b5\u03af \u03bc\u03b5 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03b1\u03c3\u03af\u03b5\u03c2 \u03cc\u03c0\u03c9\u03c2 <em>\u0391\u03bd\u03b1\u03bb\u03cd\u03c3\u03b5\u03b9\u03c2 \u03b9\u03c0\u03c0\u03cc\u03ba\u03b1\u03bc\u03c0\u03bf\u03c5<\/em> (\u03c0\u03bf\u03c5 \u03bc\u03b5\u03c4\u03c1\u03bf\u03cd\u03bd \u03c4\u03bf\u03c5\u03c2 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c1\u03c5\u03b8\u03bc\u03bf\u03cd\u03c2 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae\u03c2 \u0391\u03a4\u03a1). \u039f\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 ARLA \u03b5\u03af\u03c7\u03b1\u03bd \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf\u03c5\u03c2 \u03c1\u03c5\u03b8\u03bc\u03bf\u03cd\u03c2 OXPHOS \u03b1\u03c0\u03cc \u03c4\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0394\u03b5\u03cd\u03c4\u03b5\u03c1\u03bf\u03bd, \u03c4\u03b1 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03a4 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 (Tregs) \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03c5\u03ac\u03c1\u03b9\u03b8\u03bc\u03b1. \u039c\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c4\u03b1\u03c5\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd \u03bc\u03b5 \u03c4\u03b7 \u03b2\u03bf\u03ae\u03b8\u03b5\u03b9\u03b1 <em>\u039a\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03bc\u03b5\u03c4\u03c1\u03af\u03b1 \u03c1\u03bf\u03ae\u03c2<\/em> \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 CD4+CD25+Foxp3+. \u039f\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 ARLA \u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c5\u03c7\u03bd\u03ac \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03cc\u03bb\u03c5\u03c4\u03bf \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc Tregs, \u03bc\u03b5\u03c1\u03b9\u03ba\u03ad\u03c2 \u03c6\u03bf\u03c1\u03ad\u03c2 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf \u03b1\u03c0\u03cc \u03cc,\u03c4\u03b9 \u03c3\u03c4\u03b1 \u03c5\u03b3\u03b9\u03ae \u03ac\u03c4\u03bf\u03bc\u03b1. \u0398\u03b1 \u03c0\u03b5\u03c1\u03af\u03bc\u03b5\u03bd\u03b5 \u03ba\u03b1\u03bd\u03b5\u03af\u03c2 \u03cc\u03c4\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 Tregs \u03b8\u03b1 \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03c3\u03b1\u03bd \u03c3\u03b5 \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae, \u03b1\u03bb\u03bb\u03ac \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03c4\u03bf \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03bf, \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03b1\u03c5\u03c4\u03ac \u03c4\u03b1 Tregs \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ac. \u03a0\u03b1\u03c1\u03ac\u03b3\u03bf\u03c5\u03bd \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03b7 IL-10 \u03b1\u03bd\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf, \u03b7 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ae \u03c4\u03bf\u03c5\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ae \u03ba\u03b1\u03b9 \u03b5\u03c0\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03b4\u03b5\u03bd \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b5\u03bb\u03ad\u03b3\u03be\u03bf\u03c5\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c4\u03b1 \u03b1\u03c5\u03c4\u03bf\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03a4 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03c1\u03af\u03c4\u03bf\u03bd, \u03b7 \u03b1\u03bd\u03b1\u03bb\u03bf\u03b3\u03af\u03b1 IL-10\/IFN-\u03b3 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03be\u03b1\u03b9\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03b1\u03bd\u03b9\u03c3\u03cc\u03c1\u03c1\u03bf\u03c0\u03b7. \u03a3\u03c4\u03bf\u03c5\u03c2 \u03c5\u03b3\u03b9\u03b5\u03af\u03c2 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2, \u03b7 IL-10 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c4\u03bf\u03c5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03bf\u03bd \u03c4\u03cc\u03c3\u03bf \u03c5\u03c8\u03b7\u03bb\u03ae \u03cc\u03c3\u03bf \u03b7 IFN-\u03b3, \u03b1\u03bd \u03cc\u03c7\u03b9 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7. \u03a3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 ARLA, \u03b7 IFN-\u03b3 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 (\u03b5\u03ba\u03b1\u03c4\u03bf\u03bd\u03c4\u03ac\u03b4\u03b5\u03c2 \u03c6\u03bf\u03c1\u03ad\u03c2 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c3\u03c4\u03bf \u03b1\u03c1\u03b8\u03c1\u03b9\u03ba\u03cc \u03c5\u03b3\u03c1\u03cc \u03b1\u03c0\u03cc \u03cc,\u03c4\u03b9 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03c5\u03b3\u03b9\u03b5\u03af\u03c2 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2) \u03ba\u03b1\u03b9 \u03b7 IL-10 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ae. \u0391\u03c5\u03c4\u03ae \u03b7 \u03b1\u03bd\u03b9\u03c3\u03bf\u03c1\u03c1\u03bf\u03c0\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ce\u03c2 \u03ad\u03bd\u03b1\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf\u03c5\u03c2 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 \u03c4\u03b7\u03c2 \u03c3\u03bf\u03b2\u03b1\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03b7\u03c2 ARLA.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03ad\u03c4\u03b1\u03c1\u03c4\u03bf\u03bd, \u03bf\u03b9 \u03c4\u03af\u03c4\u03bb\u03bf\u03b9 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03b9. \u0391\u03c5\u03c4\u03bf\u03af \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 <em>\u0391\u03bd\u03c4\u03b9-OspA \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/em> (\u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf\u03c5 \u03c4\u03b7\u03c2 Borrelia, \u03b1\u03bb\u03bb\u03ac \u03b7 \u03b1\u03bd\u03c4\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03b5\u03c0\u03b9\u03bc\u03ad\u03bd\u03b5\u03b9), \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03c9\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u03c4\u03bf\u03c5 \u03af\u03b4\u03b9\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd \u03c4\u03bf\u03c5 \u03c7\u03cc\u03bd\u03b4\u03c1\u03bf\u03c5, \u03cc\u03c0\u03c9\u03c2 \u03bf\u03b9 <em>\u039a\u03bf\u03bb\u03bb\u03b1\u03b3\u03cc\u03bd\u03bf \u03c4\u03cd\u03c0\u03bf\u03c5 \u0399\u0399<\/em> \u03ba\u03b1\u03b9 <em>Aggrecan<\/em>, \u03bc\u03b5\u03c1\u03b9\u03ba\u03ad\u03c2 \u03c6\u03bf\u03c1\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf <em>\u03a1\u03b5\u03c5\u03bc\u03b1\u03c4\u03bf\u03b5\u03b9\u03b4\u03ae\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2<\/em> \u03ba\u03b1\u03b9 <em>\u0391\u03bd\u03c4\u03b9-CCP \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/em>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039c\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 Huaier \u03bc\u03b5 20 g\/\u03b7\u03bc\u03ad\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03b1\u03c1\u03ba\u03b5\u03c4\u03ad\u03c2 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03ad\u03c9\u03c2 \u03bc\u03ae\u03bd\u03b5\u03c2, \u03b2\u03bb\u03ad\u03c0\u03bf\u03c5\u03bc\u03b5 \u03c4\u03b9\u03c2 \u03b1\u03ba\u03cc\u03bb\u03bf\u03c5\u03b8\u03b5\u03c2 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf <strong>\u03b7 \u03bc\u03b9\u03c4\u03bf\u03c7\u03bf\u03bd\u03b4\u03c1\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03b1\u03c0\u03bd\u03bf\u03ae \u03bf\u03bc\u03b1\u03bb\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9<\/strong>. \u0391\u03c5\u03c4\u03cc \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b5\u03c4\u03c1\u03b7\u03b8\u03b5\u03af \u03bc\u03b5 \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03b9\u03c0\u03c0\u03cc\u03ba\u03b1\u03bc\u03c0\u03bf\u03c5. \u03a4\u03bf <strong><em>\u0392\u03b1\u03c3\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03c0\u03bd\u03bf\u03ae<\/em> \u03ba\u03b1\u03b9 \u03bf \u03c1\u03c5\u03b8\u03bc\u03cc\u03c2 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae\u03c2 \u0391\u03a4\u03a1 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03c4\u03b9\u03bc\u03ad\u03c2<\/strong>. \u0391\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b5\u03c4\u03c1\u03ae\u03c3\u03b9\u03bc\u03bf \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c0\u03b1\u03c1\u03b1\u03b3\u03ce\u03b3\u03b9\u03bc\u03bf. \u039f \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03bc\u03b5\u03c3\u03bf\u03bb\u03b1\u03b2\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd PI3K\/AKT \u03bc\u03b9\u03c4\u03bf\u03c7\u03bf\u03bd\u03b4\u03c1\u03b9\u03b1\u03ba\u03ae \u03b2\u03b9\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7 \u03bc\u03ad\u03c3\u03c9 \u03b5\u03c0\u03b1\u03b3\u03c9\u03b3\u03ae\u03c2 \u03c4\u03b7\u03c2 PGC1\u03b1, \u03cc\u03c0\u03c9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03ac\u03c6\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03c0\u03ac\u03bd\u03c9.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf <strong>\u03a4\u03b1 Tregs \u03b3\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ac<\/strong>. \u0391\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03b4\u03cd\u03c3\u03ba\u03bf\u03bb\u03bf \u03bd\u03b1 \u03bc\u03b5\u03c4\u03c1\u03b7\u03b8\u03b5\u03af, \u03b1\u03bb\u03bb\u03ac \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b1 \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9\u03b1: \u03b7 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae IL-10 \u03b1\u03bd\u03ac Treg \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 (\u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b5\u03c4\u03c1\u03b7\u03b8\u03b5\u03af \u03bc\u03b5 \u03c7\u03c1\u03ce\u03c3\u03b7 \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03b9\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03bc\u03b5\u03c4\u03c1\u03af\u03b1 \u03c1\u03bf\u03ae\u03c2). \u0397 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 Foxp3 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 (\u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 Foxp3 \u03b1\u03bd\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf). \u0397 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 in vitro \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b5\u03c4\u03c1\u03b7\u03b8\u03b5\u03af \u03bc\u03b5 \u03b4\u03bf\u03ba\u03b9\u03bc\u03b1\u03c3\u03af\u03b5\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2. \u038c\u03c4\u03b1\u03bd \u03c4\u03b1 Tregs \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd ARLA \u03c3\u03c5\u03bd\u03ba\u03b1\u03bb\u03bb\u03b9\u03b5\u03c1\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03a4 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03c4\u03b1 Tregs \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bd \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b1 \u03c4\u03bf\u03bd \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc \u03c4\u03c9\u03bd \u03a4 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 Huaier.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf <strong>\u039f \u03bb\u03cc\u03b3\u03bf\u03c2 IL-10\/IFN-\u03b3 \u03bf\u03bc\u03b1\u03bb\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b4\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac<\/strong>. \u03a4\u03bf \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03c4\u03b7\u03c2 IFN-\u03b3 \u03c3\u03c5\u03c7\u03bd\u03ac \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac 50-70% \u03ba\u03b1\u03b9 \u03c4\u03bf \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03c4\u03b7\u03c2 IL-10 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac 100-200%. \u0391\u03c5\u03c4\u03cc \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03b1\u03bd\u03b1\u03bb\u03bf\u03b3\u03af\u03b1 \u03c0\u03bf\u03c5 \u03bc\u03bf\u03b9\u03ac\u03b6\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03c0\u03ac\u03bb\u03b9 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae, \u03cc\u03c7\u03b9 \u03c0\u03b9\u03b1 \u03bc\u03b9\u03b1 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03bb\u03bf\u03b3\u03af\u03b1 1:100, \u03b1\u03bb\u03bb\u03ac \u03c0\u03b9\u03bf \u03ba\u03bf\u03bd\u03c4\u03ac \u03c3\u03c4\u03bf 1:1 \u03ae \u03b1\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03ba\u03c1\u03ac\u03c4\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 IL-10.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf <strong>\u039c\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c4\u03af\u03c4\u03bb\u03c9\u03bd \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd<\/strong>. \u0391\u03c5\u03c4\u03cc \u03b4\u03b9\u03b1\u03c1\u03ba\u03b5\u03af \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf, \u03c3\u03c5\u03c7\u03bd\u03ac 8-12 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2, \u03b1\u03bb\u03bb\u03ac \u03bf\u03b9 \u03c4\u03af\u03c4\u03bb\u03bf\u03b9 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ac. \u03a4\u03bf \u03b1\u03bd\u03c4\u03b9-OspA \u03c0\u03ad\u03c6\u03c4\u03b5\u03b9 \u03c0\u03c1\u03ce\u03c4\u03bf, \u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03c9\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u03c4\u03bf\u03c5 \u03c7\u03cc\u03bd\u03b4\u03c1\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03af\u03b4\u03b9\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c0\u03ad\u03c6\u03c4\u03bf\u03c5\u03bd \u03b1\u03c1\u03b3\u03cc\u03c4\u03b5\u03c1\u03b1. \u0391\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03c3\u03b7\u03bc\u03ac\u03b4\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u0392-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bb\u03cc\u03b3\u03c9 \u03c4\u03bf\u03c5 \u03bf\u03bc\u03b1\u03bb\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 \u03c4\u03c9\u03bd \u03a4-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (\u03c4\u03b1 Tregs \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bd \u03c4\u03b9\u03c2 \u03b1\u03c0\u03b1\u03bd\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c4\u03c9\u03bd \u0392-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf <strong>\u0397 \u03ba\u03bf\u03b9\u03bd\u03ae \u03c3\u03c5\u03bb\u03bb\u03bf\u03b3\u03ae \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9<\/strong>. \u0391\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03c0\u03b9\u03bf \u03bf\u03c1\u03b1\u03c4\u03cc \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03ba\u03b1\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b5\u03c4\u03c1\u03b7\u03b8\u03b5\u03af \u03bc\u03b5 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7, \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03ae \u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7 \u03ae \u03c5\u03c0\u03b5\u03c1\u03b7\u03c7\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03bc\u03b1. \u039c\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b7 IL-10 \u03ba\u03b1\u03b9 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03b7 TNF-\u03b1\/IL-6, \u03b7 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03c4\u03b1\u03be\u03af\u03b1 \u03c4\u03c9\u03bd \u03bb\u03b5\u03c5\u03ba\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03c4\u03b7\u03bd \u03ac\u03c1\u03b8\u03c1\u03c9\u03c3\u03b7 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b7 \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03c3\u03b1 \u03c3\u03c5\u03bb\u03bb\u03bf\u03b3\u03ae \u03b1\u03c0\u03bf\u03c1\u03c1\u03bf\u03c6\u03ac\u03c4\u03b1\u03b9. \u039c\u03b9\u03b1 \u03c3\u03c5\u03bb\u03bb\u03bf\u03b3\u03ae 200-300 mL \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b5\u03b9\u03c9\u03b8\u03b5\u03af \u03c3\u03b5 50-100 mL \u03ae \u03bd\u03b1 \u03b5\u03be\u03b1\u03c6\u03b1\u03bd\u03b9\u03c3\u03c4\u03b5\u03af \u03b5\u03bd\u03c4\u03b5\u03bb\u03ce\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf <strong>\u03c4\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03bd\u03b1\u03bb\u03cc\u03b3\u03c9\u03c2<\/strong>\u039f \u03c0\u03cc\u03bd\u03bf\u03c2 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9, \u03b7 \u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9, \u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03bf\u03c5\u03bd \u03be\u03b1\u03bd\u03ac \u03c4\u03b9\u03c2 \u03b1\u03c1\u03b8\u03c1\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5\u03c2. \u0397 \u03c0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b6\u03c9\u03ae\u03c2 \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b4\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac. \u03a0\u03bf\u03bb\u03bb\u03bf\u03af \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c4\u03bf\u03c5 ARLA \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03ac\u03c6\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03ba\u03ac\u03bd\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03c0\u03ac\u03bb\u03b9 \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ad\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c0\u03c1\u03ce\u03c4\u03b7 \u03c6\u03bf\u03c1\u03ac \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 (\u03bd\u03b1 \u03b1\u03bd\u03b5\u03b2\u03b1\u03af\u03bd\u03bf\u03c5\u03bd \u03c3\u03ba\u03ac\u03bb\u03b5\u03c2, \u03bd\u03b1 \u03c0\u03b7\u03b3\u03b1\u03af\u03bd\u03bf\u03c5\u03bd \u03b3\u03b9\u03b1 \u03c8\u03ce\u03bd\u03b9\u03b1, \u03bd\u03b1 \u03b1\u03b8\u03bb\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9).<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Ribosomale_Homoostase_Tanaka-Hauptfund\"><\/span>\u039f\u03bc\u03bf\u03b9\u03cc\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c1\u03b9\u03b2\u03bf\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd (\u03ba\u03cd\u03c1\u03b9\u03bf \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1 Tanaka)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf \u03c4\u03ad\u03c4\u03b1\u03c1\u03c4\u03bf \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03c0\u03b1\u03c1\u03ad\u03bc\u03b2\u03b1\u03c3\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03b5\u03c0\u03b1\u03af\u03c3\u03b8\u03b7\u03c4\u03bf \u03b1\u03bb\u03bb\u03ac \u03b4\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03bf, \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03b9\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 Tanaka \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03c9\u03bd \u03c1\u03b9\u03b2\u03bf\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd. \u0391\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af \u03b7 \u03c5\u03c0\u03cc\u03b8\u03b5\u03c3\u03b7: \u03c3\u03c4\u03b7\u03bd ARLA, \u03b7 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1, \u03b5\u03c0\u03af\u03bc\u03bf\u03bd\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd TLR2 \u03ba\u03b1\u03b9 TLR7\/8 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03c7\u03c1\u03cc\u03bd\u03b9\u03bf ER stress. \u03a4\u03bf \u03b5\u03bd\u03b4\u03bf\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03b4\u03af\u03ba\u03c4\u03c5\u03bf (ER) \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c7\u03ce\u03c2 \u03bd\u03b1 \u03b4\u03b9\u03c0\u03bb\u03ce\u03bd\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03b5\u03c1\u03ce\u03bd\u03b5\u03b9 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b5\u03c2 \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03bd\u03ad\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd, \u03ad\u03c4\u03c3\u03b9 \u03ce\u03c3\u03c4\u03b5 \u03c4\u03b1 \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c0\u03c1\u03c9\u03c4\u03b5\u03bf\u03c3\u03c4\u03b1\u03c4\u03ac\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03bd\u03b1 \u03c5\u03c0\u03b5\u03c1\u03c6\u03bf\u03c1\u03c4\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c7\u03ce\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u038c\u03c4\u03b1\u03bd \u03c4\u03bf ER \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c5\u03c0\u03cc \u03c7\u03c1\u03cc\u03bd\u03b9\u03bf \u03c3\u03c4\u03c1\u03b5\u03c2, \u03c4\u03bf \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf \u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03ac \u03bc\u03b5 \u03c4\u03b7 \u03bb\u03b5\u03b3\u03cc\u03bc\u03b5\u03bd\u03b7 \u201e\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b1\u03bd\u03b1\u03b4\u03b9\u03c0\u03bb\u03c9\u03bc\u03ad\u03bd\u03c9\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd\u201c (<em>UPR<\/em>). \u039f UPR \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2, \u03b1\u03bb\u03bb\u03ac \u03b1\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03b9 \u03c0\u03c1\u03bf\u03b2\u03bb\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c2.<br>\u0388\u03bd\u03b1 \u03bc\u03ad\u03c1\u03bf\u03c2 \u03c4\u03bf\u03c5 UPR \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c6\u03c9\u03c3\u03c6\u03bf\u03c1\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd <em>eIF2\u03b1<\/em> (\u03b5\u03c5\u03ba\u03b1\u03c1\u03c5\u03c9\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 \u03ad\u03bd\u03b1\u03c1\u03be\u03b7\u03c2 2 \u03ac\u03bb\u03c6\u03b1) \u03b1\u03c0\u03cc <em>HRI<\/em> (Heme-Regulated Inhibitor Kinase) \u03ae \u03ac\u03bb\u03bb\u03b5\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b5\u03c2. \u038c\u03c4\u03b1\u03bd \u03bf eIF2\u03b1 \u03c6\u03c9\u03c3\u03c6\u03bf\u03c1\u03c5\u03bb\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9, \u03bf \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03cc\u03c2 \u03c1\u03c5\u03b8\u03bc\u03cc\u03c2 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9. \u0391\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03c3\u03c4\u03b9\u03ba\u03cc, \u03b4\u03b9\u03cc\u03c4\u03b9 \u03c4\u03bf \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf \u03b4\u03b5\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b4\u03b9\u03c0\u03bb\u03ce\u03c3\u03b5\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03b5\u03ac\u03bd \u03c4\u03bf ER \u03b5\u03af\u03bd\u03b1\u03b9 \u03ae\u03b4\u03b7 \u03c5\u03c0\u03b5\u03c1\u03c6\u03bf\u03c1\u03c4\u03c9\u03bc\u03ad\u03bd\u03bf.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u038c\u03c4\u03b1\u03bd \u03b7 <em>\u03a1\u03c5\u03b8\u03bc\u03cc\u03c2 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd<\/em> \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ac, \u03bf\u03b9 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03ac \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c7\u03ce\u03c2 \u03c0\u03c1\u03bf\u03ba\u03b5\u03b9\u03bc\u03ad\u03bd\u03bf\u03c5 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03b7\u03b8\u03b5\u03af \u03b7 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c7\u03ae \u03b4\u03b5\u03bd \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc \u03c4\u03c1\u03cc\u03c0\u03bf. \u03a3\u03b5 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b7 IL-10, \u03bf TGF-\u03b2 \u03ba\u03b1\u03b9 \u03b7 Foxp3. \u03a0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5\u03b3\u03ac\u03bb\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03bf\u03bc\u03b9\u03ba\u03ac \u03c0\u03bf\u03bb\u03cd\u03c0\u03bb\u03bf\u03ba\u03b5\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd \u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03c1\u03b9\u03b2\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03ae \u03c0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b5\u03b9\u03bc\u03ad\u03bd\u03bf\u03c5 \u03bd\u03b1 \u03b1\u03bd\u03b1\u03b4\u03b9\u03c0\u03bb\u03c9\u03b8\u03bf\u03cd\u03bd \u03b2\u03ad\u03bb\u03c4\u03b9\u03c3\u03c4\u03b1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03c4\u03b1 \u03af\u03b4\u03b9\u03b1 \u03c4\u03b1 \u03c1\u03b9\u03b2\u03bf\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03b1\u03c6\u03bf\u03cd\u03bd \u03c5\u03c0\u03cc \u03c4\u03bf \u03c3\u03c4\u03c1\u03b5\u03c2 ER. \u039f\u03b9 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b5\u03c2 \u03c1\u03b9\u03b2\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03ad\u03c2 \u03c5\u03c0\u03bf\u03bc\u03bf\u03bd\u03ac\u03b4\u03b5\u03c2 (<em>60S<\/em>) \u03ba\u03b1\u03b9 \u03bc\u03b9\u03ba\u03c1\u03ad\u03c2 \u03c1\u03b9\u03b2\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03ad\u03c2 \u03c5\u03c0\u03bf\u03bc\u03bf\u03bd\u03ac\u03b4\u03b5\u03c2 (<em>40S<\/em>) \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03bf\u03bb\u03cd\u03c0\u03bb\u03bf\u03ba\u03b7 \u03b4\u03bf\u03bc\u03ae \u03ba\u03b1\u03b9 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7.<br>\u038c\u03c4\u03b1\u03bd \u03c4\u03bf ER \u03c5\u03c6\u03af\u03c3\u03c4\u03b1\u03c4\u03b1\u03b9 \u03c3\u03c4\u03c1\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03b9 \u03c0\u03ac\u03c1\u03b1 \u03c0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03bb\u03b1\u03bd\u03b8\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03b4\u03b9\u03c0\u03bb\u03c9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2, \u03bf\u03b9 \u03bb\u03b1\u03bd\u03b8\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03b4\u03b9\u03c0\u03bb\u03c9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03bf\u03c5\u03bd \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03c1\u03b9\u03b2\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03c4\u03b9\u03c2 \u03b2\u03bb\u03ac\u03c8\u03bf\u03c5\u03bd, \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03c0\u03bf\u03c5 \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03b5\u03b9\u03c1\u03ac \u03c4\u03bf\u03c5 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03bc\u03b7 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03bc\u03ad\u03c2 \u03c4\u03bf\u03c5 \u03c1\u03b9\u03b2\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03bf\u03cd RNA, \u03cc\u03c0\u03c9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03ad\u03b3\u03c1\u03b1\u03c8\u03b5 \u03bf Tanaka \u03c3\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c4\u03bf\u03c5 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03b5\u03bc\u03b2\u03bf\u03bb\u03b9\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 mRNA.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0395\u03ac\u03bd \u03c4\u03b1 \u03c1\u03b9\u03b2\u03bf\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c5\u03c0\u03bf\u03c3\u03c4\u03bf\u03cd\u03bd \u03b2\u03bb\u03ac\u03b2\u03b7 \u03c3\u03b5 \u03b4\u03bf\u03bc\u03b9\u03ba\u03cc \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf, \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b5\u03be\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03bf\u03cd\u03bd \u03bd\u03b1 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd\u03bd, \u03b1\u03bb\u03bb\u03ac \u03cc\u03c7\u03b9 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc \u03c4\u03c1\u03cc\u03c0\u03bf. \u0391\u03c5\u03c4\u03cc \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c3\u03b5<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u039c\u03b5\u03c4\u03b1\u03c6\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03c6\u03ac\u03bb\u03bc\u03b1\u03c4\u03b1<\/li>\n\n\n\n<li>\u03b1\u03bd\u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03bf\u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7<\/li>\n\n\n\n<li>\u03b5\u03bb\u03b1\u03c4\u03c4\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2, \u03b9\u03b4\u03af\u03c9\u03c2 \u03b4\u03bf\u03bc\u03b9\u03ba\u03ac \u03c0\u03bf\u03bb\u03cd\u03c0\u03bb\u03bf\u03ba\u03b5\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03b7 IL-10<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u0391\u03c5\u03c4\u03cc \u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac \u03c4\u03bf \u03c0\u03c1\u03cc\u03b2\u03bb\u03b7\u03bc\u03b1 \u03b1\u03c5\u03c4\u03bf\u03c4\u03c1\u03bf\u03c6\u03bf\u03b4\u03bf\u03c4\u03bf\u03cd\u03bc\u03b5\u03bd\u03bf: \u03c6\u03c4\u03c9\u03c7\u03ac \u03c1\u03b9\u03b2\u03bf\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u2192 \u03c6\u03c4\u03c9\u03c7\u03ae \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7 IL-10 \u2192 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03b7 IL-10 \u03c3\u03c4\u03bf \u03c0\u03b5\u03c1\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd \u2192 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c7\u03ae \u2192 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a0\u03ce\u03c2 \u03bf Huaier \u03b4\u03b9\u03bf\u03c1\u03b8\u03ce\u03bd\u03b5\u03b9 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 Huaier \u03b1\u03c3\u03c7\u03bf\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03bf\u03bc\u03bf\u03b9\u03cc\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c1\u03b9\u03b2\u03bf\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03c4\u03b7 \u03bc\u03b5\u03c3\u03bf\u03bb\u03ac\u03b2\u03b7\u03c3\u03b7 miRNA. \u039f Tanaka \u03c0\u03b5\u03c1\u03b9\u03ad\u03b3\u03c1\u03b1\u03c8\u03b5 \u03cc\u03c4\u03b9 <strong>Huaier<\/strong> \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7\u03c2 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03c9\u03bd miRNAs \u03c4\u03bf <strong>\u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b4\u03bf\u03bc\u03ae \u03c4\u03bf\u03c5 \u03c1\u03b9\u03b2\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03bf\u03cd RNA \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7<\/strong>. \u0391\u03c5\u03c4\u03cc \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03bc\u03ad\u03c3\u03c9 \u03c4\u03c9\u03bd \u03b1\u03ba\u03cc\u03bb\u03bf\u03c5\u03b8\u03c9\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03ce\u03bd:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a0\u03c1\u03ce\u03c4\u03bf\u03bd, \u03c4\u03bf Huaier \u03b5\u03c0\u03ac\u03b3\u03b5\u03b9 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 miRNAs \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u03c0\u03bf\u03c5 \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03c1\u03b9\u03b2\u03bf\u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2. \u0393\u03b9\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1, \u03c4\u03b1 miRNAs \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03c3\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u03c0\u03bf\u03c5 \u03c3\u03c5\u03c3\u03c3\u03c9\u03c1\u03b5\u03cd\u03bf\u03c5\u03bd \u03ba\u03b1\u03ba\u03ce\u03c2 \u03b4\u03b9\u03c0\u03bb\u03c9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03c3\u03c4\u03b1 \u03c1\u03b9\u03b2\u03bf\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0394\u03b5\u03cd\u03c4\u03b5\u03c1\u03bf\u03bd, \u03bf Huaier <strong>\u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b7\u03bd \u03b1\u03c5\u03c4\u03bf\u03c6\u03b1\u03b3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03c0\u03c1\u03c9\u03c4\u03b5\u03ac\u03c3\u03c9\u03bc\u03b1<\/strong>, \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03b9\u03ba\u03bf\u03b4\u03cc\u03bc\u03b7\u03c3\u03b7 \u03ba\u03b1\u03c4\u03b5\u03c3\u03c4\u03c1\u03b1\u03bc\u03bc\u03ad\u03bd\u03c9\u03bd \u03c1\u03b9\u03b2\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03ce\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c0\u03b1\u03bb\u03b1\u03b9\u03ce\u03bd \u03c1\u03b9\u03b2\u03bf\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd. \u0391\u03c5\u03c4\u03cc \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b5\u03bd \u03bc\u03ad\u03c1\u03b5\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd \u03b1\u03c5\u03c4\u03bf\u03c6\u03b1\u03b3\u03af\u03b1\u03c2 \u03bc\u03b5 miRNA. \u039c\u03b5 \u03c4\u03b7\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b1\u03c5\u03c4\u03bf\u03c6\u03b1\u03b3\u03af\u03b1, \u03c4\u03b1 \u03c0\u03b1\u03bb\u03b9\u03ac, \u03ba\u03b1\u03c4\u03b5\u03c3\u03c4\u03c1\u03b1\u03bc\u03bc\u03ad\u03bd\u03b1 \u03c1\u03b9\u03b2\u03bf\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c0\u03bf\u03bc\u03b1\u03ba\u03c1\u03cd\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03c1\u03af\u03c4\u03bf\u03bd, \u03b7 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 PI3K\/AKT \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd Huaier (\u03c4\u03b7\u03bd \u03bf\u03c0\u03bf\u03af\u03b1 \u03c3\u03c5\u03b6\u03b7\u03c4\u03ae\u03c3\u03b1\u03bc\u03b5 \u03c3\u03c4\u03bf \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03bf \u03c3\u03b7\u03bc\u03b5\u03af\u03bf) <strong>\u0395\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03bf mTOR<\/strong>, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b4\u03b9\u03b5\u03b3\u03b5\u03af\u03c1\u03b5\u03b9 \u03c4\u03b7 \u03bc\u03b5\u03c4\u03ac\u03c6\u03c1\u03b1\u03c3\u03b7, \u03b1\u03bb\u03bb\u03ac \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b4\u03b9\u03b5\u03b3\u03b5\u03af\u03c1\u03b5\u03b9 \u03c4\u03b7 \u03b2\u03b9\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7 \u03bd\u03ad\u03c9\u03bd \u03c1\u03b9\u03b2\u03bf\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd. \u0391\u03c5\u03c4\u03cc \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b5\u03bd\u03ce \u03c4\u03b1 \u03c0\u03b1\u03bb\u03b9\u03ac \u03c1\u03b9\u03b2\u03bf\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c0\u03bf\u03bc\u03b1\u03ba\u03c1\u03cd\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b1\u03c5\u03c4\u03bf\u03c6\u03b1\u03b3\u03af\u03b1, <strong>\u03bd\u03ad\u03b1, \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ac \u03c1\u03b9\u03b2\u03bf\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong> \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03b5\u03be\u03b1\u03c1\u03c4\u03ce\u03bc\u03b5\u03bd\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf mTOR \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7\u03c2 rRNA \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03c1\u03b9\u03b2\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03ce\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd <strong>\u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c7\u03b8\u03b5\u03af<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03b1\u03c1\u03ba\u03b5\u03c4\u03ad\u03c2 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 <strong>\u039a\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03bf\u03cd \u03c4\u03c9\u03bd \u03c1\u03b9\u03b2\u03bf\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd<\/strong>. \u03a4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03bb\u03ad\u03bf\u03bd \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ac \u03c1\u03b9\u03b2\u03bf\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03c9\u03c3\u03c4\u03ae \u03b4\u03bf\u03bc\u03ae. \u0391\u03c5\u03c4\u03cc \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b7 IL-10, \u03bf TGF-\u03b2 \u03ba\u03b1\u03b9 \u03bf Foxp3 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c3\u03c5\u03bd\u03c4\u03b5\u03b8\u03bf\u03cd\u03bd \u03be\u03b1\u03bd\u03ac \u03bc\u03b5 \u03c4\u03bf\u03bd \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc \u03c4\u03c1\u03cc\u03c0\u03bf. \u03a4\u03bf <strong>\u03a0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2<\/strong>, \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 <strong>\u0394\u03bf\u03bc\u03b9\u03ba\u03ac \u03c3\u03c9\u03c3\u03c4\u03ae \u03ba\u03b1\u03b9 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0391\u03c5\u03c4\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c0\u03b9\u03bf \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03af\u03c3\u03c9\u03c2 \u03b7 \u03c0\u03b9\u03bf \u03b1\u03c1\u03b3\u03ae \u03c0\u03b1\u03c1\u03ad\u03bc\u03b2\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 Huaier. \u03a7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 4-8 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03ae \u03ba\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 \u03b1\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c1\u03b9\u03b2\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03ae\u03c2 \u03c0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2. \u0391\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03b8\u03b5\u03bc\u03b5\u03bb\u03b9\u03ce\u03b4\u03b5\u03c2, \u03b4\u03b9\u03cc\u03c4\u03b9 \u03b1\u03c0\u03bf\u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac \u03c4\u03b7\u03bd \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03bd\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03c5\u03bd \u03c4\u03b9\u03c2 \u03af\u03b4\u03b9\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c7\u03ae.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Mechanistischer_Vergleich_Huaier_zu_Biologika\"><\/span>\u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 Huaier \u03bc\u03b5 \u03c4\u03b1 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u038c\u03c8\u03b7<\/th><th>TNFi<\/th><th>IL-6i<\/th><th>JAK1i<\/th><th>HUAIER<\/th><\/tr><\/thead><tbody><tr><td><strong>NF-\u03baB \u03bc\u03c0\u03bb\u03bf\u03ba\u03b1\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf<\/strong><\/td><td>\u0388\u03bc\u03bc\u03b5\u03c3\u03b7 (\u2193TNF)<\/td><td>\u0388\u03bc\u03bc\u03b5\u03c3\u03b7 (\u2193IL-6)<\/td><td>\u0388\u03bc\u03bc\u03b5\u03c3\u03b7 (\u2193JAK1)<\/td><td>\u0386\u03bc\u03b5\u03c3\u03b7 (\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03bf\u03c5 NF-\u03ba\u0392)<\/td><\/tr><tr><td><strong>JAK\/STAT \u03bc\u03c0\u03bb\u03bf\u03ba\u03b1\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf<\/strong><\/td><td>\u038c\u03c7\u03b9<\/td><td>\u039c\u03b5\u03c1\u03b9\u03ba\u03ae (\u03b4\u03b9\u03b1\u03b4\u03c1\u03bf\u03bc\u03ae IL-6)<\/td><td>\u039d\u0391\u0399 (\u03c0\u03bf\u03bb\u03cd \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae)<\/td><td>JA (\u03bc\u03ad\u03c3\u03c9 miRNA, \u03b1\u03c3\u03b8\u03b5\u03bd\u03ad\u03c3\u03c4\u03b5\u03c1\u03bf)<\/td><\/tr><tr><td><strong>\u0395\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 PI3K\/AKT<\/strong><\/td><td>\u038c\u03c7\u03b9<\/td><td>\u038c\u03c7\u03b9<\/td><td>\u038c\u03c7\u03b9<\/td><td>\u039d\u0391\u0399 (\u0394\u03a5\u039d\u0391\u03a4\u0391!)<\/td><\/tr><tr><td><strong>\u03a1\u03b9\u03b2\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03ae \u03c0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1<\/strong><\/td><td>\u038c\u03c7\u03b9<\/td><td>\u038c\u03c7\u03b9<\/td><td>\u038c\u03c7\u03b9<\/td><td>JA (\u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 miRNA)<\/td><\/tr><tr><td><strong>\u03a5\u03c0\u03bf\u03c3\u03c4\u03ae\u03c1\u03b9\u03be\u03b7 Treg<\/strong><\/td><td>\u0391\u03b4\u03cd\u03bd\u03b1\u03bc\u03bf<\/td><td>\u0391\u03b4\u03cd\u03bd\u03b1\u03bc\u03bf<\/td><td>\u0391\u03b4\u03cd\u03bd\u03b1\u03bc\u03b7 (\u03b7 JAK3 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03bc\u03c0\u03bb\u03bf\u03ba\u03b1\u03c1\u03b9\u03c3\u03c4\u03b5\u03af)<\/td><td>STARK (\u03bc\u03ad\u03c3\u03c9 PI3K\/AKT + \u03c1\u03b9\u03b2\u03bf\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1)<\/td><\/tr><tr><td><strong>\u0391\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 IL-10<\/strong><\/td><td>\u0395\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03bf<\/td><td>\u0395\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03bf<\/td><td>\u03a7\u03b1\u03bc\u03b7\u03bb\u03ae<\/td><td>STARK (\u03bc\u03ad\u03c3\u03c9 \u03c1\u03b9\u03b2\u03bf\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd + \u03c5\u03c0\u03bf\u03c3\u03c4\u03ae\u03c1\u03b9\u03be\u03b7 Treg)<\/td><\/tr><tr><td><strong>\u0388\u03bd\u03b1\u03c1\u03be\u03b7<\/strong><\/td><td>4-8 Wo<\/td><td>4-12 Wo<\/td><td>2-4 Wo<\/td><td>4-8 Wo (\u03ba\u03b1\u03c4' \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7)<\/td><\/tr><tr><td><strong>\u039a\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03bc\u03cc\u03bb\u03c5\u03bd\u03c3\u03b7\u03c2<\/strong><br><\/td><td>\u0391\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf<\/td><td>\u039c\u03ad\u03c4\u03c1\u03b9\u03b1<\/td><td>\u039c\u03ad\u03c4\u03c1\u03b9\u03b1<\/td><td>\u03a7\u0391\u039c\u0397\u039b\u0397 (\u03c7\u03c9\u03c1\u03af\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae!)<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Dosierungsempfehlung_bei_ARLA_im_fortgeschrittenen_Stadium\"><\/span>Dosierungsempfehlung bei ARLA im fortgeschrittenen Stadium<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>ARLA \u03c3\u03b5 \u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03bf \u03c3\u03c4\u03ac\u03b4\u03b9\u03bf \u03bc\u03b5 \u03c0\u03c1\u03bf\u03c3\u03b2\u03bf\u03bb\u03ae \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ce\u03bd \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03bd<\/strong>&nbsp;\u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af \u03c3\u03b5 \u03c3\u03bf\u03b2\u03b1\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03ac\u03c1\u03c5\u03bd\u03c3\u03b7 \u03c3\u03c4\u03b9\u03c2 \u03c0\u03b9\u03bf \u03c3\u03bf\u03b2\u03b1\u03c1\u03ad\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u03a7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c0\u03bf\u03bb\u03c5\u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03ba\u03ae \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae<\/li>\n\n\n\n<li>\u0391\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03bf \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc<\/li>\n\n\n\n<li>\u03a0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03bf\u03af \u03b1\u03c5\u03c4\u03bf\u03c4\u03c1\u03bf\u03c6\u03bf\u03b4\u03bf\u03c4\u03bf\u03cd\u03bc\u03b5\u03bd\u03bf\u03b9 \u03b2\u03c1\u03cc\u03c7\u03bf\u03b9 \u03b1\u03bd\u03b1\u03c4\u03c1\u03bf\u03c6\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7\u03c2<\/li>\n\n\n\n<li>\u039c\u03b9\u03c4\u03bf\u03c7\u03bf\u03bd\u03b4\u03c1\u03b9\u03b1\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1<\/li>\n\n\n\n<li>\u03a1\u03b9\u03b2\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03ae \u03b2\u03bb\u03ac\u03b2\u03b7<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Vorschlag_fur_ARLA-Dosierung\"><\/span>\u03a0\u03c1\u03cc\u03c4\u03b1\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 ARLA<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a3\u03cd\u03c3\u03c4\u03b1\u03c3\u03b7: 50-60g\/\u03b7\u03bc\u03ad\u03c1\u03b1<\/strong><br>\u03a7\u03c9\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 3 \u03b1\u03c0\u03bf\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2, \u03ba\u03ac\u03b8\u03b5 \u03bc\u03af\u03b1 \u03bc\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac 8 \u03c9\u03c1\u03ce\u03bd<br>\u038c\u03c0\u03c9\u03c2 \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03bc\u03b5 \u03cc\u03bb\u03b1 \u03c4\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1, \u03b7 \u03c3\u03c5\u03b3\u03ba\u03ad\u03bd\u03c4\u03c1\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03b5\u03c0\u03b9\u03b4\u03b9\u03c9\u03ba\u03cc\u03bc\u03b5\u03bd\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1. \u039a\u03b1\u03b8\u03ce\u03c2 \u03c4\u03b1 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ac \u03b4\u03b9\u03b1\u03c3\u03c0\u03ce\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03ae \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b3\u03c1\u03ae\u03b3\u03bf\u03c1\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03ac\u03c1\u03bf\u03b4\u03bf \u03c4\u03bf\u03c5 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c5, \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03bf \u03bd\u03b1 \u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03ba\u03c1\u03af\u03b2\u03b5\u03b9\u03b1 \u03c4\u03bf \u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03cc \u03b4\u03b9\u03ac\u03c3\u03c4\u03b7\u03bc\u03b1 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03c9\u03bd \u03b4\u03cc\u03c3\u03b5\u03c9\u03bd, \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03cc \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03b8' \u03cc\u03bb\u03b7 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03b7\u03bc\u03ad\u03c1\u03b1\u03c2!<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0393\u03b9\u03b1\u03c4\u03af 50 - 60 g\/d \u03b1\u03bd\u03c4\u03af \u03b3\u03b9\u03b1 \u03c0.\u03c7. 40 g\/d:<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>\u03a3\u03bf\u03b2\u03b1\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1<\/strong>: \u0397 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae \u03c0\u03bf\u03bb\u03bb\u03ce\u03bd \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af \u03c3\u03b5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c3\u03c4\u03b1\u03b4\u03af\u03bf\u03c5 IV \u03c3\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 Tanaka<\/li>\n\n\n\n<li><strong>\u03a0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03bf\u03af \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2<\/strong>: \u039a\u03b1\u03b9 \u03bf\u03b9 4 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03c9\u03c0\u03b9\u03c3\u03c4\u03bf\u03cd\u03bd \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b1<\/li>\n\n\n\n<li><strong>\u0395\u03be\u03ac\u03c1\u03c4\u03b7\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03b4\u03cc\u03c3\u03b7<\/strong>\u0397 Tanaka \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03b5\u03b9 \u03c3\u03b1\u03c6\u03ae \u03b5\u03be\u03ac\u03c1\u03c4\u03b7\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03b4\u03cc\u03c3\u03b7 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1<\/li>\n\n\n\n<li><strong>\u03a0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c2<\/strong>: \u03a5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b1\u03bd \u03bd\u03b1 \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c8\u03bf\u03c5\u03bd \u03c4\u03b1\u03c7\u03cd\u03c4\u03b5\u03c1\u03b7 \u03ad\u03bd\u03b1\u03c1\u03be\u03b7<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0394\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c3\u03c7\u03ae\u03bc\u03b1 (\u03c0\u03c1\u03cc\u03c4\u03b1\u03c3\u03b7):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u03a6\u03ac\u03c3\u03b7 1 (\u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 1-4)<\/strong><br>60g\/\u03b7\u03bc\u03ad\u03c1\u03b1 (\u03c7\u03c9\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03c3\u03b5 3x20g)<br>\u0395\u03c3\u03c4\u03af\u03b1\u03c3\u03b7: \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03bf\u03c5 NF-\u03baB, \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03bc\u03cc\u03c1\u03c6\u03c9\u03c3\u03b7\u03c2 JAK\/STAT<br>\u039a\u03cc\u03c3\u03c4\u03bf\u03c2 \/ \u03bc\u03ae\u03bd\u03b1 (\u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5) 568,- \u03b5\u03c5\u03c1\u03ce<\/li>\n\n\n\n<li><strong>\u03a6\u03ac\u03c3\u03b7 2 (\u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 5-12)<\/strong><br>50g\/\u03b7\u03bc\u03ad\u03c1\u03b1 (3\u00d716-17g)<br>\u0395\u03c3\u03c4\u03af\u03b1\u03c3\u03b7: \u03c0\u03bb\u03ae\u03c1\u03c9\u03c2 \u03ba\u03b1\u03b8\u03b9\u03b5\u03c1\u03c9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 JAK\/STAT, \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 PI3K\/AKT<br>\u039a\u03cc\u03c3\u03c4\u03bf\u03c2 \/ \u03bc\u03ae\u03bd\u03b1 (\u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5) 473,- \u03b5\u03c5\u03c1\u03ce<\/li>\n\n\n\n<li><strong>\u03a6\u03ac\u03c3\u03b7 3 (\u03bc\u03ae\u03bd\u03b5\u03c2 4-6)<\/strong><br>40g\/\u03b7\u03bc\u03ad\u03c1\u03b1 (3x13g)<br>\u0394\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7, \u03c1\u03b9\u03b2\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7<br>\u039a\u03cc\u03c3\u03c4\u03bf\u03c2 \/ \u03bc\u03ae\u03bd\u03b1 (\u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5) 379,- \u03b5\u03c5\u03c1\u03ce<\/li>\n\n\n\n<li><strong>\u039c\u03b1\u03ba\u03c1\u03bf\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03b7 \u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7<\/strong><br>20-30g\/\u03b7\u03bc\u03ad\u03c1\u03b1 (3x 7 .. 3x 10g)<br>\u039a\u03cc\u03c3\u03c4\u03bf\u03c2 \/ \u03bc\u03ae\u03bd\u03b1 (\u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5) 189 ... 284,- \u03b5\u03c5\u03c1\u03ce<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Weitere_relevante_Beitrage_zum_Anwendungsbereich_des_Huaier-Pilzes\"><\/span>\u0386\u03bb\u03bb\u03b1 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03ac\u03c1\u03b8\u03c1\u03b1 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03bf \u03c0\u03b5\u03b4\u03af\u03bf \u03b5\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae\u03c2 \u03c4\u03bf\u03c5 \u03bc\u03b1\u03bd\u03b9\u03c4\u03b1\u03c1\u03b9\u03bf\u03cd Huaier<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u0392\u03b1\u03c3\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5<\/strong> -&gt; <a href=\"https:\/\/csiag.eu\/el\/%ce%bc%ce%b1%ce%bd%ce%b9%cf%84%ce%ac%cf%81%ce%b9-huaier-%cf%83%cf%84%ce%b7-%ce%b8%ce%b5%cf%81%ce%b1%cf%80%ce%b5%ce%af%ce%b1-%cf%84%ce%bf%cf%85-%ce%ba%ce%b1%cf%81%ce%ba%ce%af%ce%bd%ce%bf%cf%85\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/csiag.eu\/huaier-pilz-in-der-krebstherapie\/<\/a><\/li>\n\n\n\n<li><strong>\u03a7\u03c1\u03cc\u03bd\u03b9\u03b5\u03c2 \u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b5\u03c2<\/strong> -&gt; <a href=\"https:\/\/csiag.eu\/el\/huaier-%ce%bc%cf%8d%ce%ba%ce%b7%cf%84%ce%b1%cf%82-%ce%b3%ce%b9%ce%b1-%cf%87%cf%81%cf%8c%ce%bd%ce%b9%ce%b5%cf%82-%ce%b1%cf%83%ce%b8%ce%ad%ce%bd%ce%b5%ce%b9%ce%b5%cf%82\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/csiag.eu\/huaier-pilz-bei-chronischen-erkrankungen\/<\/a><\/li>\n<\/ul>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">Es gibt vermeintlich &#8222;g\u00fcnstige&#8220; Anbieter von Huaier-Granulat. Unterschied zwischen dem &#8222;teuren&#8220; und &#8222;g\u00fcnstigen&#8220; Produkt ist, dass das teure aus dem Fruchtk\u00f6rper des Huaier-Pilzes gewonen wird, w\u00e4hrend das g\u00fcnstige aus dem Myzel auf z.B. Getreide hergestellt wird, dessen Wirkstoffgehalt z.T. nur ein Zehntel betr\u00e4gt und 90% an, bei der Festk\u00f6rperfermentation, unverdautem F\u00fcllstoff enth\u00e4lt.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Hingegen sind bei Fl\u00fcssigfermentation, bei dem Myzel in n\u00e4hrstoffreichen Fl\u00fcssigmedien kultiviert wird, wiederum Wirkstoffe enthalten, die nicht aus dem Fruchtk\u00f6rper gewonnen werden k\u00f6nnen.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Als &#8222;Fruchtk\u00f6rper&#8220; bezeichnet man den Pilz, wie er optisch wahrgenommen wird, als &#8222;Myzel&#8220; das Innere des Pilzes.<\/p>\n<\/blockquote>","protected":false},"excerpt":{"rendered":"<p><span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">\u03a7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2<\/span> <span class=\"rt-time\"> 18<\/span> <span class=\"rt-label rt-postfix\">\u03bb\u03b5\u03c0\u03c4\u03ac<\/span><\/span>Borreliose wird durch Borrelia burgdorferi, einem spiralf\u00f6rmigen Bakterium, das die Lyme-Borreliose (auch Lyme-Krankheit genannt) verursacht. Er ist einer der wenigen Erreger, die wissenschaftlich derart faszinierend sind und gleichzeitig die schwierigsten bakteriellen Infektionen in Immunologie und Klinik darstellen: Die meisten Menschen mit Lyme-Arthritis erfahren Heilung nach Antibiotika-Therapie. Doch etwa 10% sprechen nicht auf diese Behandlung an&hellip;&nbsp;<a href=\"https:\/\/csiag.eu\/el\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/\" rel=\"bookmark\">\u03a0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \"<span class=\"screen-reader-text\">\u039d\u03cc\u03c3\u03bf\u03c2 \u03c4\u03bf\u03c5 Lyme - \u03a0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7 Huaier \u03b3\u03b9\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 ARLA (\u0391\u03bd\u03c4\u03b9\u03b2\u03b9\u03bf\u03c4\u03b9\u03ba\u03ac-\u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03b1\u03c1\u03b8\u03c1\u03af\u03c4\u03b9\u03b4\u03b1 Lyme)<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[1078,354],"tags":[],"class_list":["post-12268","post","type-post","status-publish","format-standard","hentry","category-medizin","category-medizin-gesundheit"],"modified_by":"Achim Goerner","_links":{"self":[{"href":"https:\/\/csiag.eu\/el\/wp-json\/wp\/v2\/posts\/12268","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csiag.eu\/el\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csiag.eu\/el\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csiag.eu\/el\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csiag.eu\/el\/wp-json\/wp\/v2\/comments?post=12268"}],"version-history":[{"count":2,"href":"https:\/\/csiag.eu\/el\/wp-json\/wp\/v2\/posts\/12268\/revisions"}],"predecessor-version":[{"id":13417,"href":"https:\/\/csiag.eu\/el\/wp-json\/wp\/v2\/posts\/12268\/revisions\/13417"}],"wp:attachment":[{"href":"https:\/\/csiag.eu\/el\/wp-json\/wp\/v2\/media?parent=12268"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csiag.eu\/el\/wp-json\/wp\/v2\/categories?post=12268"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csiag.eu\/el\/wp-json\/wp\/v2\/tags?post=12268"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}