{"id":12789,"date":"2026-02-19T18:18:00","date_gmt":"2026-02-19T18:18:00","guid":{"rendered":"https:\/\/csiag.eu\/?p=12789"},"modified":"2026-02-21T06:07:24","modified_gmt":"2026-02-21T06:07:24","slug":"%ce%b8%ce%b5%cf%81%ce%b1%cf%80%ce%b5%ce%af%ce%b1-%ce%bc%ce%b5-%ce%b1%ce%bd%ce%bf%cf%83%ce%bf%cf%80%ce%bf%ce%b9%ce%b7%cf%84%ce%b9%ce%ba%ce%ac-%ce%ba%cf%8d%cf%84%cf%84%ce%b1%cf%81%ce%b1","status":"publish","type":"post","link":"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/","title":{"rendered":"\u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_86 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 \u03c0\u03b5\u03c1\u03b9\u03b5\u03c7\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd<\/p>\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Das_Immunsystem_%E2%80%93_was_macht_das\" >\u03a4\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 - \u03c4\u03b9 \u03ba\u03ac\u03bd\u03b5\u03b9;<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Was_Immunzelltherapie_macht\" >\u03a4\u03b9 \u03ba\u03ac\u03bd\u03b5\u03b9 \u03b7 \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Das_Geniale_daran\" >\u0397 \u03b9\u03b4\u03b9\u03bf\u03c6\u03c5\u0390\u03b1 \u03c4\u03bf\u03c5<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Die_drei_Typen_%E2%80%93_ganz_einfach\" >\u039f\u03b9 \u03c4\u03c1\u03b5\u03b9\u03c2 \u03c4\u03cd\u03c0\u03bf\u03b9 - \u03c0\u03bf\u03bb\u03cd \u03b1\u03c0\u03bb\u03ac<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#T-Zellen_und_ihre_Rolle\" >\u03a4 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03bf \u03c1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03bf\u03c5\u03c2<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Tumorimmunologie-Grundprinzip\" >\u0392\u03b1\u03c3\u03b9\u03ba\u03ae \u03b1\u03c1\u03c7\u03ae \u03c4\u03b7\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 \u03c4\u03c9\u03bd \u03cc\u03b3\u03ba\u03c9\u03bd<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#CAR-T-Zelltherapie_%E2%80%93_Konstruktion_und_Mechanismus\" >CAR-T \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 - \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03cc\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Molekularer_Aufbau_des_CAR\" >\u039c\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae \u03b4\u03bf\u03bc\u03ae \u03c4\u03bf\u03c5 CAR<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Herstellungsprozess_Autolog\" >\u0394\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae\u03c2 (Autologue)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Wirkmechanismus_Effektorphase\" >\u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 &amp; \u03c6\u03ac\u03c3\u03b7 effector<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#TCR-T-Zelltherapie_Die_entscheidenden_Unterschiede\" >\u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 TCR-T \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1: \u03bf\u03b9 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Warum_TCR_und_nicht_CAR_fur_intrazellulare_Antigene\" >\u0393\u03b9\u03b1\u03c4\u03af TCR \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 CAR \u03b3\u03b9\u03b1 \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03b1;<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Struktur_des_therapeutischen_TCR\" >\u0394\u03bf\u03bc\u03ae \u03c4\u03bf\u03c5 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03bf\u03cd TCR<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#TIL-Therapie_%E2%80%93_Prinzip_der_naturlichen_Tumorerkennung\" >\u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 TIL - \u03b1\u03c1\u03c7\u03ae \u03c4\u03b7\u03c2 \u03c6\u03c5\u03c3\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Biologische_Grundlage\" >\u0392\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b2\u03ac\u03c3\u03b7<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Herstellungsprozess_Lifileucel\" >\u0394\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae\u03c2 (Lifileucel)<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Herausforderungen_%E2%80%93_aktuelle_Forschungsansatze\" >\u03a0\u03c1\u03bf\u03ba\u03bb\u03ae\u03c3\u03b5\u03b9\u03c2 - \u03c4\u03c1\u03ad\u03c7\u03bf\u03c5\u03c3\u03b5\u03c2 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03bf\u03c3\u03b5\u03b3\u03b3\u03af\u03c3\u03b5\u03b9\u03c2<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Antigen-Escape\" >\u0391\u03c0\u03cc\u03b4\u03c1\u03b1\u03c3\u03b7 \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf\u03c5<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#T-Zell-Erschopfung_Exhaustion\" >\u0395\u03be\u03ac\u03bd\u03c4\u03bb\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03a4-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (\u03b5\u03be\u03ac\u03bd\u03c4\u03bb\u03b7\u03c3\u03b7)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Tumormikroumgebung_TME\" >\u039c\u03b9\u03ba\u03c1\u03bf\u03c0\u03b5\u03c1\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5 (TME)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Zytokinsturm_CRS_ICANS\" >\u039a\u03b1\u03c4\u03b1\u03b9\u03b3\u03af\u03b4\u03b1 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd (CRS) &amp; ICANS<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Allogene_%E2%80%9EOff-the-shelf%E2%80%9C-Therapien\" >\u0391\u03bb\u03bb\u03bf\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u201e\u03ad\u03c4\u03bf\u03b9\u03bc\u03b5\u03c2\u201c \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#27_Quantitative_Wirksamkeitsdaten_im_Uberblick\" >2.7 \u03a0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03ac \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03bc\u03b5 \u03bc\u03b9\u03b1 \u03bc\u03b1\u03c4\u03b9\u03ac<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Weiterfuhrende_Literatur_Ressourcen\" >\u03a0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 &amp; \u03c0\u03cc\u03c1\u03bf\u03b9<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Weltweit_zugelassene_Immunzelltherapien\" >\u03a0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-26\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Einleitung_Die_drei_grosen_Klassen\" >\u0395\u03b9\u03c3\u03b1\u03b3\u03c9\u03b3\u03ae: \u039f\u03b9 \u03c4\u03c1\u03b5\u03b9\u03c2 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b5\u03c2 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-27\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#CAR-T-ZELLTHERAPIEN\" >\u039a\u03a5\u03a4\u03a4\u0391\u03a1\u0399\u039a\u0388\u03a3 \u0398\u0395\u03a1\u0391\u03a0\u0395\u038a\u0395\u03a3 CAR-T<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-28\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Tisagenlecleucel_Kymriah%C2%AE_%E2%80%93_Novartis\" >Tisagenlecleucel (Kymriah\u00ae) - Novartis<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-29\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Axicabtagene_Ciloleucel_Yescarta%C2%AE_%E2%80%93_KiteGilead\" >Axicabtagene ciloleucel (Yescarta\u00ae) - Kite\/Gilead<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-30\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Brexucabtagene_Autoleucel_Tecartus%C2%AE_%E2%80%93_KiteGilead\" >Brexucabtagene Autoleucel (Tecartus\u00ae) - Kite\/Gilead<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-31\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Lisocabtagene_Maraleucel_Breyanzi%C2%AE_%E2%80%93_Bristol_Myers_Squibb\" >Lisocabtagene Maraleucel (Breyanzi\u00ae) - Bristol Myers Squibb<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-32\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Idecabtagene_Vicleucel_Abecma%C2%AE_%E2%80%93_Bristol_Myers_Squibb_2seventy_bio\" >Idecabtagene Vicleucel (Abecma\u00ae) - Bristol Myers Squibb \/ 2seventy bio<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-33\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Ciltacabtagene_Autoleucel_Carvykti%C2%AE_%E2%80%93_JanssenLegend_Biotech\" >Ciltacabtagene Autoleucel (Carvykti\u00ae) - Janssen\/Legend Biotech<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-34\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Obecabtagene_Autoleucel_Aucatzyl%C2%AE_%E2%80%93_Autolus_neu_112024\" >Obecabtagene Autoleucel (Aucatzyl\u00ae) - Autolus (\u03bd\u03ad\u03b1: 11.2024)<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-35\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#WELTWEIT_ZUGELASSEN_%E2%80%93_NICHT_IN_USAEU_weitere_Lander\" >\u0395\u03a0\u0399\u03a4\u03a1\u0395\u03a0\u0395\u03a4\u0391\u0399 \u03a0\u0391\u0393\u039a\u039f\u03a3\u039c\u0399\u03a9\u03a3 - \u039f\u03a7\u0399 \u03a3\u03a4\u0399\u03a3 \u0397\u03a0\u0391\/\u0395\u0395 (\u03ac\u03bb\u03bb\u03b5\u03c2 \u03c7\u03ce\u03c1\u03b5\u03c2)<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-36\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#China_NMPA_%E2%80%93_vier_zusatzliche_CAR-T-Produkte\" >\u039a\u03af\u03bd\u03b1 (NMPA) - \u03c4\u03ad\u03c3\u03c3\u03b5\u03c1\u03b1 \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03b1 CAR-T<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-37\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Indien_CDSCO\" >\u0399\u03bd\u03b4\u03af\u03b1 (CDSCO)<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-38\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#TCR-T-ZELLTHERAPIEN_zugelassen\" >\u0398\u0395\u03a1\u0391\u03a0\u0395\u0399\u0395\u03a3 \u03bc\u03b5 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 TCR-T (\u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b5\u03c2)<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-39\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Afamitresgene_Autoleucel_Tecelra%C2%AE_%E2%80%93_Adaptimmune_August_2024\" >Afamitresgene Autoleucel (Tecelra\u00ae) - Adaptimmune (\u0391\u03cd\u03b3\u03bf\u03c5\u03c3\u03c4\u03bf\u03c2 2024)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-40\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Tebentafusp-tebn_Kimmtrak%C2%AE_%E2%80%93_Immunocore_Januar_2022\" >Tebentafusp-tebn (Kimmtrak\u00ae) - Immunocore (\u0399\u03b1\u03bd\u03bf\u03c5\u03ac\u03c1\u03b9\u03bf\u03c2 2022)<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-41\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#TIL-THERAPIE_zugelassen\" >TIL-\u0398\u0395\u03a1\u0391\u03a0\u0395\u0399\u0391 (\u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7)<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-42\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Lifileucel_Amtagvi%C2%AE_%E2%80%93_Iovance_Biotherapeutics_Februar_2024\" >Lifileucel (Amtagvi\u00ae) - Iovance Biotherapeutics (\u03a6\u03b5\u03b2\u03c1\u03bf\u03c5\u03ac\u03c1\u03b9\u03bf\u03c2 2024)<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-43\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Ubersicht_aller_Immunzelltherapien_weltweit\" >\u0395\u03c0\u03b9\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 \u03cc\u03bb\u03c9\u03bd \u03c4\u03c9\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ce\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03b9\u03ce\u03bd \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-44\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Nebenwirkungen_%E2%80%93_Was_alle_Therapien_verbindet\" >\u03a0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 - \u03c4\u03b9 \u03ba\u03bf\u03b9\u03bd\u03cc \u03ad\u03c7\u03bf\u03c5\u03bd \u03cc\u03bb\u03b5\u03c2 \u03bf\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-45\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Wo_werden_diese_Therapien_in_Deutschland_angeboten\" >\u03a0\u03bf\u03cd \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03bf\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03c3\u03c4\u03b7 \u0393\u03b5\u03c1\u03bc\u03b1\u03bd\u03af\u03b1;<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-46\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Ausblick_Was_kommt_als_nachstes\" >\u03a0\u03c1\u03bf\u03bf\u03c0\u03c4\u03b9\u03ba\u03ad\u03c2: \u03a4\u03b9 \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af;<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-47\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#GKV-Erstattung_von_Immunzelltherapien_in_Deutschland\" >\u0391\u03c0\u03bf\u03b6\u03b7\u03bc\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 SHI \u03b3\u03b9\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03bc\u03b5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c3\u03c4\u03b7 \u0393\u03b5\u03c1\u03bc\u03b1\u03bd\u03af\u03b1<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-48\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#CAR-T-Zelltherapien\" >\u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd CAR-T<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-49\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#AMNOG_NUB-Verfahren\" >\u0394\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 AMNOG &amp; NUB<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-50\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Fruhe_Nutzenbewertung_durch_den_G-BA\" >\u0388\u03b3\u03ba\u03b1\u03b9\u03c1\u03b7 \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bf\u03c6\u03ad\u03bb\u03bf\u03c5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd G-BA<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-51\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Preisverhandlung_nach_%C2%A7_130b_SGB_V\" >\u0394\u03b9\u03b1\u03c0\u03c1\u03b1\u03b3\u03bc\u03ac\u03c4\u03b5\u03c5\u03c3\u03b7 \u03c4\u03b9\u03bc\u03ce\u03bd \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03bf \u00a7 130b SGB V<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-52\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#NUB-Verfahren_fur_Krankenhauser\" >\u0394\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 NUB \u03b3\u03b9\u03b1 \u03bd\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03b1<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-53\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Die_Realitat_Einzelfallantrage_und_Burokratie\" >\u0397 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1: \u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03ad\u03c2 \u03b1\u03b9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03b3\u03c1\u03b1\u03c6\u03b5\u03b9\u03bf\u03ba\u03c1\u03b1\u03c4\u03af\u03b1<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-54\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Das_%E2%80%9EPay-for-Outcome%E2%80%9C-Modell\" >\u03a4\u03bf \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03bf \u201e\u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ae \u03b3\u03b9\u03b1 \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1\u201c<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-55\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Welche_CAR-T-Produkte_sind_in_Deutschland_erstattungsfahig\" >\u03a0\u03bf\u03b9\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03b1 CAR-T \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03b9\u03bb\u03ad\u03be\u03b9\u03bc\u03b1 \u03b3\u03b9\u03b1 \u03b1\u03c0\u03bf\u03b6\u03b7\u03bc\u03af\u03c9\u03c3\u03b7 \u03c3\u03c4\u03b7 \u0393\u03b5\u03c1\u03bc\u03b1\u03bd\u03af\u03b1;<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-56\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Kimmtrak_Tebentafusp_%E2%80%93_Sonderfall\" >Kimmtrak (Tebentafusp) - \u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-57\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#TIL-Therapie_Lifileucel_Amtagvi_%E2%80%93_In_Deutschland_derzeit_NICHT_erstattungsfahig\" >\u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 TIL (Lifileucel \/ Amtagvi) - \u0395\u03c0\u03af \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c1\u03cc\u03bd\u03c4\u03bf\u03c2 \u0394\u0395\u039d \u03b1\u03c0\u03bf\u03b6\u03b7\u03bc\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u0393\u03b5\u03c1\u03bc\u03b1\u03bd\u03af\u03b1<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-58\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#TCR-T-Therapien_Afami-cel_Tecelra_%E2%80%93_In_Europa_nicht_zugelassen\" >TCR-T \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 (Afami-cel \/ Tecelra) - \u0394\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03b3\u03ba\u03c1\u03b9\u03b8\u03b5\u03af \u03c3\u03c4\u03b7\u03bd \u0395\u03c5\u03c1\u03ce\u03c0\u03b7<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-59\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Was_tun_wenn_die_Kasse_ablehnt_Rechtliche_Moglichkeiten\" >\u03a4\u03b9 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03ba\u03ac\u03bd\u03b5\u03c4\u03b5 \u03b5\u03ac\u03bd \u03b7 \u03b1\u03c3\u03c6\u03b1\u03bb\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b5\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b1 \u03b1\u03c1\u03bd\u03b7\u03b8\u03b5\u03af; \u039d\u03bf\u03bc\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-60\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Osterreich\" >\u0391\u03c5\u03c3\u03c4\u03c1\u03af\u03b1<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-61\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Schweiz\" >\u0395\u03bb\u03b2\u03b5\u03c4\u03af\u03b1<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-62\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Zusammenfassung\" >\u03a0\u03b5\u03c1\u03af\u03bb\u03b7\u03c8\u03b7<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-63\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#PKV_und_Immunzelltherapie_%E2%80%93_Die_vollstandige_Rechtslage\" >PKV \u03ba\u03b1\u03b9 \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 - \u03b7 \u03c0\u03bb\u03ae\u03c1\u03b7\u03c2 \u03bd\u03bf\u03bc\u03b9\u03ba\u03ae \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-64\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Das_rechtliche_Fundament_%C2%A7_192_VVG_und_MBKK_2009\" >\u0397 \u03bd\u03bf\u03bc\u03b9\u03ba\u03ae \u03b2\u03ac\u03c3\u03b7: \u00a7 192 VVG \u03ba\u03b1\u03b9 MB\/KK 2009<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-65\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Der_Schlusselbegriff_%E2%80%9EMedizinisch_notwendige_Heilbehandlung%E2%80%9C\" >\u039f \u03cc\u03c1\u03bf\u03c2 \u03ba\u03bb\u03b5\u03b9\u03b4\u03af: \u201e\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ac \u03b1\u03bd\u03b1\u03b3\u03ba\u03b1\u03af\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u201c<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-66\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Das_Richtungsurteil_OLG_Frankfurt_29062022_%E2%80%93_Az_7_U_14021\" >\u0397 \u03b1\u03c0\u03cc\u03c6\u03b1\u03c3\u03b7-\u03bf\u03c1\u03cc\u03c3\u03b7\u03bc\u03bf: OLG \u03a6\u03c1\u03b1\u03bd\u03ba\u03c6\u03bf\u03cd\u03c1\u03c4\u03b7\u03c2, 29.06.2022 - Ref. 7 U 140\/21<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-67\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Das_%E2%80%9Eauffallige_Missverhaltnis%E2%80%9C_nach_%C2%A7_192_Abs_2_VVG_%E2%80%93_und_warum_es_bei_CAR-T_nicht_greift\" >\u0397 \u201e\u03b5\u03bc\u03c6\u03b1\u03bd\u03ae\u03c2 \u03b4\u03c5\u03c3\u03b1\u03bd\u03b1\u03bb\u03bf\u03b3\u03af\u03b1\u201c \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03ac\u03c1\u03b8\u03c1\u03bf 192 \u03c0\u03b1\u03c1\u03ac\u03b3\u03c1\u03b1\u03c6\u03bf\u03c2 2 VVG - \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1\u03c4\u03af \u03b4\u03b5\u03bd \u03b9\u03c3\u03c7\u03cd\u03b5\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd CAR-T<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-68\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Das_Voranfrageverfahren_nach_%C2%A7_192_Abs_8_VVG_%E2%80%93_der_wichtigste_praktische_Schritt\" >\u0397 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03c4\u03b1\u03c1\u03ba\u03c4\u03b9\u03ba\u03ae\u03c2 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1\u03c2 \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03ac\u03c1\u03b8\u03c1\u03bf 192 \u03c0\u03b1\u03c1\u03ac\u03b3\u03c1\u03b1\u03c6\u03bf\u03c2 8 VVG - \u03c4\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03bf \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03cc \u03b2\u03ae\u03bc\u03b1<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-69\" href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/#Bei_Ablehnung_Rechtsmittel_und_Klage\" >\u03a3\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03b1\u03c0\u03cc\u03c1\u03c1\u03b9\u03c8\u03b7\u03c2: \u03c0\u03c1\u03bf\u03c3\u03c6\u03c5\u03b3\u03ae \u03ba\u03b1\u03b9 \u03bd\u03bf\u03bc\u03b9\u03ba\u03ad\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">\u03a7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2<\/span> <span class=\"rt-time\"> 20<\/span> <span class=\"rt-label rt-postfix\">\u03bb\u03b5\u03c0\u03c4\u03ac<\/span><\/span>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Das_Immunsystem_%E2%80%93_was_macht_das\"><\/span>\u03a4\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 - \u03c4\u03b9 \u03ba\u03ac\u03bd\u03b5\u03b9;<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03b5\u03af \u03ad\u03bd\u03b1\u03bd \u03bf\u03bb\u03cc\u03ba\u03bb\u03b7\u03c1\u03bf \u03c3\u03c4\u03c1\u03b1\u03c4\u03cc \u03b1\u03c0\u03cc \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03c5\u03c4\u03ad\u03c2, \u03bc\u03b1\u03c7\u03b7\u03c4\u03ad\u03c2 (<em>\u03a4-\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1<\/em>) \u03ba\u03b1\u03b9 \u03b2\u03bf\u03b7\u03b8\u03bf\u03cd\u03c2. \u03a0\u03b5\u03c1\u03b9\u03c0\u03bf\u03bb\u03bf\u03cd\u03bd \u03c3\u03c5\u03bd\u03b5\u03c7\u03ce\u03c2 \u03c4\u03bf \u03c3\u03ce\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03b6\u03b7\u03c4\u03bf\u03cd\u03bd \u03b5\u03b9\u03c3\u03b2\u03bf\u03bb\u03b5\u03af\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03b2\u03b1\u03ba\u03c4\u03ae\u03c1\u03b9\u03b1, \u03b9\u03bf\u03cd\u03c2, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03af\u03b4\u03b9\u03b1 \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03b3\u03c1\u03b9\u03ad\u03c8\u03b5\u03b9 - \u03c4\u03b1 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039a\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03ac, \u03c4\u03ad\u03c4\u03bf\u03b9\u03b1 \u03b1\u03bd\u03b5\u03be\u03ad\u03bb\u03b5\u03b3\u03ba\u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b5\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b3\u03c1\u03ae\u03b3\u03bf\u03c1\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03c6\u03cd\u03bb\u03b1\u03ba\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2, \u03c3\u03ba\u03bf\u03c4\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03c5\u03c0\u03bf\u03bb\u03b5\u03af\u03bc\u03bc\u03b1\u03c4\u03ac \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c0\u03bf\u03bc\u03b1\u03ba\u03c1\u03cd\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c5\u03bd\u03c4\u03af\u03b8\u03b5\u03bd\u03c4\u03b1\u03b9. \u0391\u03c5\u03c4\u03cc \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c7\u03ce\u03c2 \u03ba\u03ac\u03b8\u03b5 \u03bc\u03ad\u03c1\u03b1. \u039c\u03b5 \u03b1\u03c5\u03c4\u03cc\u03bd \u03c4\u03bf\u03bd \u03c4\u03c1\u03cc\u03c0\u03bf, \u03c4\u03b1 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03bd\u03b1 \u03b5\u03be\u03b1\u03c0\u03bb\u03c9\u03b8\u03bf\u03cd\u03bd \u03ba\u03b1\u03b9 \u03ba\u03b1\u03b8\u03af\u03c3\u03c4\u03b1\u03bd\u03c4\u03b1\u03b9 \u03b5\u03b3\u03ba\u03b1\u03af\u03c1\u03c9\u03c2 \u03b1\u03b2\u03bb\u03b1\u03b2\u03ae.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0391\u03bb\u03bb\u03ac \u03c4\u03b1 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c6\u03b5\u03c5\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03b8\u03ad\u03bb\u03bf\u03c5\u03bd \u03bd\u03b1 \u03b5\u03c0\u03b9\u03b2\u03b9\u03ce\u03c3\u03bf\u03c5\u03bd \u03c0\u03ac\u03c3\u03b7 \u03b8\u03c5\u03c3\u03af\u03b1. \u0388\u03c4\u03c3\u03b9 \u03ba\u03b1\u03bc\u03bf\u03c5\u03c6\u03bb\u03ac\u03c1\u03bf\u03bd\u03c4\u03b1\u03b9, \u03ba\u03c1\u03cd\u03b2\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03c6\u03cd\u03bb\u03b1\u03ba\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c7\u03af\u03b6\u03bf\u03c5\u03bd \u03bd\u03b1 \u03b5\u03be\u03b1\u03c0\u03bb\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c7\u03b5\u03b4\u03cc\u03bd \u03b1\u03bd\u03b5\u03be\u03ad\u03bb\u03b5\u03b3\u03ba\u03c4\u03b1. \u038c\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03ba\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03b5\u03b1\u03c5\u03c4\u03cc \u03c4\u03bf\u03c5\u03c2 \u03bc\u03b7 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03c3\u03b9\u03bc\u03bf \u03c9\u03c2 \u03b5\u03c7\u03b8\u03c1\u03cc, \u03b1\u03bb\u03bb\u03ac \u03ba\u03c1\u03b1\u03c4\u03bf\u03cd\u03bd \u03ba\u03b1\u03b9 \u03c4\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03c4\u03cc\u03c3\u03bf \u03b1\u03c0\u03b1\u03c3\u03c7\u03bf\u03bb\u03b7\u03bc\u03ad\u03bd\u03bf \u03c0\u03bf\u03c5 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03ba\u03ac\u03c0\u03bf\u03b9\u03bf \u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03cc \u03b4\u03b9\u03ac\u03c3\u03c4\u03b7\u03bc\u03b1 \u03b5\u03be\u03b1\u03bd\u03c4\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03af\u03c3\u03c9\u03c2 \u03b1\u03bd\u03b1\u03b3\u03ba\u03b1\u03c3\u03c4\u03b5\u03af \u03bd\u03b1 \u03c4\u03b5\u03bd\u03c4\u03ce\u03c3\u03b5\u03b9 \u03c4\u03b1 \u03c6\u03c4\u03b5\u03c1\u03ac \u03c4\u03bf\u03c5 - \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03c5\u03c0\u03bf\u03ba\u03cd\u03c8\u03b5\u03b9 \u03c3\u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Was_Immunzelltherapie_macht\"><\/span>\u03a4\u03b9 \u03ba\u03ac\u03bd\u03b5\u03b9 \u03b7 \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, \u03c4\u03b1 \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b1\u03c6\u03b1\u03b9\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae, \u03b5\u03be\u03bf\u03c0\u03bb\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0.\u03c7. \u03bc\u03b5 \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c4\u03b5\u03c7\u03bd\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03b1\u03bd\u03b1\u03b3\u03bd\u03ce\u03c1\u03b9\u03c3\u03b7\u03c2, \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03bc\u03b1\u03c7\u03b7\u03c4\u03b9\u03ba\u03ae \u03b4\u03cd\u03bd\u03b1\u03bc\u03b7 \u03ae \u03bc\u03b9\u03b1 \u03bd\u03ad\u03b1 \u201e\u03bf\u03c0\u03c4\u03b9\u03ba\u03ae \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03c7\u03bf\u03c5\u201c \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03ad\u03c6\u03bf\u03c5\u03bd \u03c3\u03c4\u03bf \u03c3\u03ce\u03bc\u03b1, \u03cc\u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b5\u03c0\u03b9\u03c4\u03b5\u03b8\u03bf\u03cd\u03bd \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03ad\u03c8\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03bc\u03b5 \u03c0\u03b9\u03bf \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03c4\u03c1\u03cc\u03c0\u03bf.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Das_Geniale_daran\"><\/span>\u0397 \u03b9\u03b4\u03b9\u03bf\u03c6\u03c5\u0390\u03b1 \u03c4\u03bf\u03c5<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03b5 \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03ba\u03b1\u03c4' \u03b1\u03c1\u03c7\u03ae\u03bd \u03c3\u03ba\u03bf\u03c4\u03ce\u03bd\u03b5\u03b9 \u03cc,\u03c4\u03b9 \u03b4\u03b9\u03b1\u03b9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03b3\u03c1\u03ae\u03b3\u03bf\u03c1\u03b1 (\u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b1\u03c6\u03b5\u03bd\u03cc\u03c2, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 - \u03b1\u03ba\u03bf\u03cd\u03c3\u03b9\u03b1 - \u03c4\u03c1\u03b9\u03c7\u03c9\u03c4\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ba.\u03bb\u03c0.), \u03bf\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03bc\u03b5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03bf\u03c5\u03bd \u03c3\u03b5 <strong>\u03bc\u03cc\u03bd\u03bf \u03c3\u03c4\u03b1 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1<\/strong> - \u03c4\u03bf\u03c5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03bf\u03bd \u03b8\u03b5\u03c9\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039a\u03b1\u03b8\u03ce\u03c2 \u03c4\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03b8\u03c5\u03bc\u03ac\u03c4\u03b1\u03b9 \u03c4\u03bf\u03c5\u03c2 \u03b5\u03c7\u03b8\u03c1\u03bf\u03cd\u03c2 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03b5\u03b9 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03c3\u03b5\u03b9, \u03b5\u03c0\u03b9\u03c4\u03af\u03b8\u03b5\u03c4\u03b1\u03b9 \u03b1\u03bc\u03ad\u03c3\u03c9\u03c2 \u03c3\u03c4\u03b1 \u03bd\u03ad\u03b1 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03ad\u03c6\u03b5\u03b9 \u03c3\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03bf \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03ad\u03c8\u03b5\u03b9. \u0391\u03c5\u03c4\u03cc \u03b5\u03be\u03b7\u03b3\u03b5\u03af \u03b3\u03b9\u03b1\u03c4\u03af \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03bf\u03c5\u03bd \u03bc\u03cc\u03bd\u03b9\u03bc\u03b1 \u03b1\u03c0\u03b1\u03bb\u03bb\u03b1\u03b3\u03bc\u03ad\u03bd\u03bf\u03b9 \u03b1\u03c0\u03cc \u03cc\u03b3\u03ba\u03bf\u03c5\u03c2 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03bc\u03af\u03b1 \u03bc\u03cc\u03bd\u03bf \u03ad\u03b3\u03c7\u03c5\u03c3\u03b7.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Die_drei_Typen_%E2%80%93_ganz_einfach\"><\/span>\u039f\u03b9 \u03c4\u03c1\u03b5\u03b9\u03c2 \u03c4\u03cd\u03c0\u03bf\u03b9 - \u03c0\u03bf\u03bb\u03cd \u03b1\u03c0\u03bb\u03ac<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1 CAR-T \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1: \u0397 \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03bf\u03c0\u03ae<\/strong><br>\u039b\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03a4 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 (\u03b7 \u03bc\u03b1\u03c7\u03b7\u03c4\u03b9\u03ba\u03ae \u03b4\u03cd\u03bd\u03b1\u03bc\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2) \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03ac \u03c3\u03c4\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf \u03ad\u03bd\u03b1\u03c2 \u03b5\u03bd\u03c4\u03b5\u03bb\u03ce\u03c2 \u03bd\u03ad\u03bf\u03c2 \u201e\u03b2\u03c1\u03b1\u03c7\u03af\u03bf\u03bd\u03b1\u03c2 \u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7\u03c2\u201c, \u03ad\u03bd\u03b1\u03c2 \u03c4\u03b5\u03c7\u03bd\u03b7\u03c4\u03cc\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2. \u0391\u03c5\u03c4\u03cc \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03b5\u03b9 \u03ad\u03bd\u03b1 \u03c0\u03bf\u03bb\u03cd \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03bf\u03cd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03ad\u03c6\u03b5\u03b9 \u03b1\u03c0\u03b5\u03c5\u03b8\u03b5\u03af\u03b1\u03c2 \u03c4\u03bf \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03cc \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>2 TCR T \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1: \u03a4\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b1 \u03b3\u03c5\u03b1\u03bb\u03b9\u03ac<\/strong><br>\u03a0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b1 \u03bc\u03b5 \u03c4\u03bf CAR-T, \u03b1\u03bd\u03c4\u03af \u03b3\u03b9\u03b1 \u03ad\u03bd\u03b1 \u03c4\u03b5\u03c7\u03bd\u03b7\u03c4\u03cc \u03c7\u03ad\u03c1\u03b9 \u03c0\u03bf\u03c5 \u03c0\u03b9\u03ac\u03bd\u03b5\u03b9, \u03c4\u03bf \u03a4-\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03ad\u03bd\u03b1\u03bd \u03b2\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf \u03c6\u03c5\u03c3\u03b9\u03ba\u03cc \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03b5\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b2\u03b1\u03b8\u03b9\u03ac \u03c3\u03c5\u03bd\u03b4\u03b5\u03b4\u03b5\u03bc\u03ad\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03bf \u03c3\u03ce\u03bc\u03b1. <em>\u03bc\u03ad\u03c3\u03b1 \u03c3\u03c4\u03bf<\/em> \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03bf\u03cd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03bc\u03b9\u03ba\u03c1\u03bf\u03c3\u03ba\u03bf\u03c0\u03b9\u03ba\u03ac \u03b8\u03c1\u03b1\u03cd\u03c3\u03bc\u03b1\u03c4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03c1\u03b1\u03c4\u03ac \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b1 \u03ad\u03be\u03c9.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>3\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 TIL: \u039f \u03b2\u03b5\u03c4\u03b5\u03c1\u03ac\u03bd\u03bf\u03c2<\/strong><br>\u0395\u03b4\u03ce, \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03a4 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ae\u03b4\u03b7 <em>\u03c3\u03c4\u03bf\u03bd \u03af\u03b4\u03b9\u03bf \u03c4\u03bf\u03bd \u03cc\u03b3\u03ba\u03bf<\/em> \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03c4\u03bf\u03bd \u03b3\u03bd\u03c9\u03c1\u03af\u03c3\u03b5\u03c4\u03b5. \u0395\u03be\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03b9, \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b1\u03b6\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf - \u03bb\u03af\u03b3\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b3\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b9\u03c3\u03b5\u03ba\u03b1\u03c4\u03bf\u03bc\u03bc\u03cd\u03c1\u03b9\u03b1 - \u03ba\u03b1\u03b9 \u03c3\u03c4\u03ad\u03bb\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03af\u03c3\u03c9 \u03c3\u03b5 \u03ad\u03bc\u03c0\u03b5\u03b9\u03c1\u03bf\u03c5\u03c2 \u201e\u03b2\u03b5\u03c4\u03b5\u03c1\u03ac\u03bd\u03bf\u03c5\u03c2\u201c.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"T-Zellen_und_ihre_Rolle\"><\/span>\u03a4 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03bf \u03c1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03bf\u03c5\u03c2<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03c3\u03c4\u03b9\u03ba\u03cc \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b4\u03cd\u03bf \u03ba\u03cd\u03c1\u03b9\u03bf\u03c5\u03c2 \u03c4\u03cd\u03c0\u03bf\u03c5\u03c2 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd: <strong>\u0392-\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1<\/strong> (\u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd) \u03ba\u03b1\u03b9 <strong>\u03a4-\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1<\/strong> (\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c3\u03af\u03b1). \u03a4\u03b1 \u03a4-\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c7\u03c9\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b4\u03cd\u03bf \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03bf\u03cd\u03c2, \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03c1\u03c9\u03c4\u03b1\u03c1\u03c7\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03b3\u03b9\u03b1 \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ad\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>CD8+ \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03ac \u03a4 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 (CTL)<\/strong><br>\u0391\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c3\u03cd\u03bc\u03c0\u03bb\u03bf\u03ba\u03b1 \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03c9\u03bd-MHC \u03c4\u03ac\u03be\u03b7\u03c2 \u0399 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03bc\u03bf\u03bb\u03c5\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03ae \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03bc\u03ad\u03c3\u03c9 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03a4-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (TCR) \u03ba\u03b1\u03b9 \u03b5\u03c0\u03ac\u03b3\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03ae \u03c4\u03bf\u03c5\u03c2 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03ad\u03c1\u03c9\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03c6\u03bf\u03c1\u03af\u03bd\u03b7\u03c2\/\u03b3\u03ba\u03c1\u03b1\u03bd\u03b6\u03cd\u03bc\u03bf\u03c5 \u0392 \u03ae \u03c4\u03b7\u03c2 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7\u03c2 FasL\/Fas.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>CD4+ \u03b2\u03bf\u03b7\u03b8\u03b7\u03c4\u03b9\u03ba\u03ac \u03a4 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1<\/strong><br>\u03a3\u03c5\u03bd\u03c4\u03bf\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd (IL-2, IFN-\u03b3, TNF-\u03b1) \u03ba\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03bf\u03bd\u03ae \u03c4\u03b7\u03c2 CTL-\u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0395\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b2\u03ac\u03c3\u03b7:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0392\u03b1\u03c3\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03c9\u03bd \u03a4-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd: <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK10757\/\" target=\"_blank\" rel=\"noopener\">\u0391\u03bd\u03bf\u03c3\u03bf\u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 Janeway (\u03b2\u03b9\u03b2\u03bb\u03b9\u03bf\u03b8\u03ae\u03ba\u03b7 NCBI)<\/a><\/li>\n\n\n\n<li>\u0395\u03c0\u03b9\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03be\u03ac\u03bd\u03c4\u03bb\u03b7\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03a4-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf: <a href=\"https:\/\/www.nature.com\/articles\/nri3862\" target=\"_blank\" rel=\"noopener\">Wherry &amp; Kurachi, Nature Reviews Immunology 2015<\/a><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Tumorimmunologie-Grundprinzip\"><\/span>\u0392\u03b1\u03c3\u03b9\u03ba\u03ae \u03b1\u03c1\u03c7\u03ae \u03c4\u03b7\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 \u03c4\u03c9\u03bd \u03cc\u03b3\u03ba\u03c9\u03bd<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03b4\u03b5\u03bd \u03b1\u03bd\u03b1\u03c0\u03c4\u03cd\u03c3\u03c3\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03ba\u03b5\u03bd\u03cc. \u03a4\u03bf <strong>\u0391\u03bd\u03bf\u03c3\u03bf\u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5<\/strong>-\u03ad\u03bd\u03bd\u03bf\u03b9\u03b1 (Dunn, Bruce &amp; Schreiber, 2004) \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03ac\u03c6\u03b5\u03b9 \u03c4\u03c1\u03b5\u03b9\u03c2 \u03c6\u03ac\u03c3\u03b5\u03b9\u03c2:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0395\u03be\u03ac\u03bb\u03b5\u03b9\u03c8\u03b7<\/strong><br>\u03a4\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03ad\u03c6\u03b5\u03b9 \u03c4\u03b1 \u03bc\u03b5\u03c4\u03b1\u03c3\u03c7\u03b7\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03c9\u03bd \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03cc\u03b3\u03ba\u03bf (TAA) \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03cc\u03b3\u03ba\u03bf \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03c9\u03bd (TSA). \u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03c3\u03b7 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b1\u03b3\u03bc\u03ad\u03bd\u03c9\u03bd \u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03c9\u03bd \u03bc\u03b5 \u03c4\u03b7 \u03bc\u03b5\u03c3\u03bf\u03bb\u03ac\u03b2\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 MHC-I \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b1 CTL.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0399\u03c3\u03bf\u03c1\u03c1\u03bf\u03c0\u03af\u03b1<\/strong><br>\u03a4\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03b5\u03af \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5 \u03c3\u03b5 \u03b9\u03c3\u03bf\u03c1\u03c1\u03bf\u03c0\u03af\u03b1, \u03b1\u03bb\u03bb\u03ac \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b1 \u03b5\u03c0\u03b9\u03bb\u03ad\u03b3\u03b5\u03b9 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c4\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0391\u03c0\u03cc\u03b4\u03c1\u03b1\u03c3\u03b7<\/strong><br>\u03a4\u03b1 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b4\u03b9\u03b1\u03c6\u03b5\u03cd\u03b3\u03bf\u03c5\u03bd \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03c5\u03c0\u03bf\u03c1\u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 MHC-I, \u03c4\u03b7\u03c2 \u03c5\u03c0\u03b5\u03c1\u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c3\u03b7\u03bc\u03b5\u03af\u03c9\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 (\u03c3\u03c5\u03bd\u03b4\u03ad\u03c4\u03b5\u03c2 PD-L1, CTLA-4), \u03c4\u03b7\u03c2 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd (TGF-\u03b2, IL-10) \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03c3\u03c4\u03c1\u03b1\u03c4\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7\u03c2 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03a4-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (Tregs).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0395\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b2\u03ac\u03c3\u03b7:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(02)00272-3\" target=\"_blank\" rel=\"noopener\">Dunn et al, Immunity 2002<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(13)00272-X\" target=\"_blank\" rel=\"noopener\">Chen &amp; Mellman, Immunity 2013 - \u039a\u03cd\u03ba\u03bb\u03bf\u03c2 \u03b1\u03bd\u03bf\u03c3\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5<\/a><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"CAR-T-Zelltherapie_%E2%80%93_Konstruktion_und_Mechanismus\"><\/span>CAR-T \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 - \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03cc\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Molekularer_Aufbau_des_CAR\"><\/span>\u039c\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae \u03b4\u03bf\u03bc\u03ae \u03c4\u03bf\u03c5 CAR<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f \u03c7\u03b9\u03bc\u03b1\u03b9\u03c1\u03b9\u03ba\u03cc\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf\u03c5 (CAR) \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03c3\u03c5\u03bd\u03b8\u03b5\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03bc\u03b5\u03bc\u03b2\u03c1\u03b1\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03bc\u03b5 \u03c4\u03ad\u03c3\u03c3\u03b5\u03c1\u03b9\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c4\u03bf\u03bc\u03b5\u03af\u03c2:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1. \u03c4\u03bf\u03bc\u03ad\u03b1\u03c2 \u03b5\u03be\u03c9\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b4\u03ad\u03c3\u03bc\u03b5\u03c5\u03c3\u03b7\u03c2<\/strong><br>\u039a\u03c5\u03c1\u03af\u03c9\u03c2 \u03ad\u03bd\u03b1 <strong>scFv<\/strong> (\u03bc\u03b5\u03c4\u03b1\u03b2\u03bb\u03b7\u03c4\u03cc \u03c4\u03bc\u03ae\u03bc\u03b1 \u03bc\u03bf\u03bd\u03ae\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b1\u03c2) \u03b5\u03bd\u03cc\u03c2 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03bf\u03cd \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2. \u0394\u03b5\u03c3\u03bc\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03b5\u03c5\u03b8\u03b5\u03af\u03b1\u03c2 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1\u03c2 (\u03c0.\u03c7. CD19 \u03c3\u03c4\u03b1 \u0392 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, BCMA \u03c3\u03c4\u03b1 \u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1) \u03bc\u03b5 \u03c4\u03c1\u03cc\u03c0\u03bf \u03b1\u03bd\u03b5\u03be\u03ac\u03c1\u03c4\u03b7\u03c4\u03bf \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd MHC. \u0391\u03c5\u03c4\u03ae \u03b7 \u03b1\u03bd\u03b5\u03be\u03b1\u03c1\u03c4\u03b7\u03c3\u03af\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd MHC \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03b8\u03b5\u03bc\u03b5\u03bb\u03b9\u03ce\u03b4\u03b7 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03c6\u03c5\u03c3\u03b9\u03ba\u03cc TCR.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>2. \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae \u03bc\u03b5\u03bd\u03c4\u03b5\u03c3\u03ad\u03b4\u03c9\u03bd\/\u03c3\u03c5\u03bd\u03b4\u03ad\u03c3\u03bc\u03c9\u03bd<\/strong><br>\u0395\u03cd\u03ba\u03b1\u03bc\u03c0\u03c4\u03bf\u03c2 \u03b1\u03c0\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae\u03c2 \u03c0\u03c1\u03cc\u03c3\u03b4\u03b5\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae\u03c2 \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03bd\u03b7\u03c2 (\u03c0.\u03c7. IgG4-Hinge, CD8\u03b1-Hinge). \u03a4\u03bf \u03bc\u03ae\u03ba\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03b7 \u03b5\u03c5\u03b5\u03bb\u03b9\u03be\u03af\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03bf\u03c5\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>3. \u03b4\u03b9\u03b1\u03bc\u03b5\u03bc\u03b2\u03c1\u03b1\u03bd\u03b9\u03ba\u03cc\u03c2 \u03c4\u03bf\u03bc\u03ad\u03b1\u03c2<\/strong><br>\u0391\u03b3\u03ba\u03c5\u03c1\u03bf\u03b2\u03bf\u03bb\u03b5\u03af \u03c4\u03bf CAR \u03c3\u03c4\u03b7 \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03bd\u03b7 \u03c4\u03bf\u03c5 \u03a4-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03bf\u03c5- \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03c3\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>4. \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7\u03c2<\/strong><br>\u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c0\u03c1\u03c9\u03c4\u03bf\u03b3\u03b5\u03bd\u03ae \u03c4\u03bf\u03bc\u03ad\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 (CD3\u03b6 \u03bc\u03b5 3 ITAMs) + \u03c3\u03c5\u03bd\u03b4\u03b9\u03b5\u03b3\u03b5\u03c1\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c4\u03bf\u03bc\u03b5\u03af\u03c2. \u039f\u03b9 \u03c3\u03c5\u03bd\u03b4\u03b9\u03b5\u03b3\u03b5\u03c1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ad\u03c2 \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd <strong>\u0393\u03b5\u03bd\u03b9\u03ac CAR:<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u0393\u03b5\u03bd\u03b9\u03ac<\/th><th>\u03a3\u03c5\u03bd\u03b4\u03b9\u03ad\u03b3\u03b5\u03c1\u03c3\u03b7<\/th><th>\u03a7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03b3\u03bd\u03ce\u03c1\u03b9\u03c3\u03bc\u03b1<\/th><\/tr><\/thead><tbody><tr><td>\u0393\u03b5\u03bd. 1<\/td><td>\u039c\u03cc\u03bd\u03bf CD3\u03b6<\/td><td>\u0392\u03c1\u03b1\u03c7\u03cd\u03b2\u03b9\u03b1, \u03b1\u03b4\u03cd\u03bd\u03b1\u03bc\u03bf\u03c2 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc\u03c2<\/td><\/tr><tr><td>2\u03b7 \u03b3\u03b5\u03bd\u03b9\u03ac<\/td><td>CD28 <strong>\u03ae<\/strong> 4-1BB (CD137) + CD3\u03b6<\/td><td>Kymriah=4-1BB; Yescarta=CD28<\/td><\/tr><tr><td>3\u03b7 \u03b3\u03b5\u03bd\u03b9\u03ac<\/td><td>CD28 <strong>\u03ba\u03b1\u03b9<\/strong> 4-1BB + CD3\u03b6<\/td><td>\u0399\u03c3\u03c7\u03c5\u03c1\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7, \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 CRS<\/td><\/tr><tr><td>4\u03b7 \u03b3\u03b5\u03bd\u03b9\u03ac<\/td><td>2\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf + \u03b4\u03b9\u03b1\u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf (\u03c0.\u03c7. IL-12, IL-15)<\/td><td>\u201eArmored CAR\u201c, \u03b2\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf \u03bc\u03b9\u03ba\u03c1\u03bf\u03c0\u03b5\u03c1\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd \u03cc\u03b3\u03ba\u03bf\u03c5<\/td><\/tr><tr><td>5\u03b7 \u03b3\u03b5\u03bd\u03b9\u03ac<\/td><td>2\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf + \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae IL-2R\u03b2<\/td><td>Jagged-CAR; \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03bf\u03c4\u03b9\u03ba\u03ae \u03bf\u03b4\u03cc\u03c2 JAK-STAT<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a3\u03c5\u03bd\u03b4\u03b9\u03ad\u03b3\u03b5\u03c1\u03c3\u03b7 4-1BB \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 CD28<\/strong><br>\u039f\u03b9 4-1BB-CARs (Kymriah) \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03bf\u03c5\u03bd \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b5\u03bc\u03bc\u03bf\u03bd\u03ae \u03ba\u03b1\u03b9 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b5\u03be\u03ac\u03bd\u03c4\u03bb\u03b7\u03c3\u03b7 (\u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b5\u03be\u03ac\u03bd\u03c4\u03bb\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03a4-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd), \u03bf\u03b9 CD28-CARs (Yescarta) \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03bf\u03c5\u03bd \u03c4\u03b1\u03c7\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ae \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03c0\u03c1\u03ce\u03b9\u03bc\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2, \u03b1\u03bb\u03bb\u03ac \u03c4\u03b5\u03af\u03bd\u03bf\u03c5\u03bd \u03bd\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0395\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b2\u03ac\u03c3\u03b7:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0395\u03c0\u03b9\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae\u03c2 CAR: <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMra1706169\" target=\"_blank\" rel=\"noopener\">June &amp; Sadelain, NEJM 2018<\/a><\/li>\n\n\n\n<li>\u03a3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 4-1BB \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 CD28: <a href=\"https:\/\/www.nature.com\/articles\/s41591-018-0087-0\" target=\"_blank\" rel=\"noopener\">Salter et al, Nature Medicine 2018<\/a><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Herstellungsprozess_Autolog\"><\/span>\u0394\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae\u03c2 (Autologue)<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039b\u03b5\u03c5\u03ba\u03b1\u03c6\u03b1\u03af\u03c1\u03b5\u03c3\u03b7<\/strong><br>\u0397 \u03c3\u03c5\u03bb\u03bb\u03bf\u03b3\u03ae \u03bc\u03bf\u03bd\u03bf\u03c0\u03cd\u03c1\u03b7\u03bd\u03c9\u03bd \u03b1\u03b9\u03bc\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03c9\u03bd \u03b1\u03c0\u03cc \u03c4\u03bf \u03b1\u03af\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2 \u03bc\u03ad\u03c3\u03c9 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03bf\u03cd \u03b4\u03b9\u03b1\u03c7\u03c9\u03c1\u03b9\u03c3\u03bc\u03bf\u03cd \u03c3\u03b5 \u03b4\u03b9\u03ac\u03c3\u03c4\u03b7\u03bc\u03b1 3-5 \u03c9\u03c1\u03ce\u03bd.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0395\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03a4-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd<\/strong><br>\u0394\u03b9\u03ad\u03b3\u03b5\u03c1\u03c3\u03b7 ex vivo \u03bc\u03b5 \u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03b4\u03b9\u03b1 \u03b5\u03c0\u03b9\u03ba\u03b1\u03bb\u03c5\u03bc\u03bc\u03ad\u03bd\u03b1 \u03bc\u03b5 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 anti-CD3\/anti-CD28 \u03ae \u03b1\u03bd\u03b1\u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03c3\u03c5\u03bd\u03b4\u03ad\u03c4\u03b5\u03c2- \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 IL-2 \u03ba\u03b1\u03b9 IL-7\/IL-15 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03ce\u03b8\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03bf\u03cd.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039c\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd<\/strong><br>\u0395\u03b9\u03c3\u03b1\u03b3\u03c9\u03b3\u03ae \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 CAR \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03ce\u03bd\u03c4\u03b1\u03c2:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Lentiviral vector<\/strong> (Kymriah, Breyanzi): \u03a3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ae \u03b5\u03bd\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03c3\u03b7 \u03c3\u03c4\u03bf \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03be\u03b5\u03bd\u03b9\u03c3\u03c4\u03ae- \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7<\/li>\n\n\n\n<li><strong>\u0393\u03b1\u03bc\u03bc\u03b1\u03c1\u03b5\u03c4\u03c1\u03bf\u03ca\u03b9\u03ba\u03cc\u03c2 \u03c6\u03bf\u03c1\u03ad\u03b1\u03c2<\/strong> (Yescarta, Tecartus): \u03a0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b1, \u03b1\u03bb\u03bb\u03ac \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b1\u03be\u03b9\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2 \u03bb\u03cc\u03b3\u03c9 \u03b5\u03b9\u03c3\u03b1\u03b3\u03c9\u03b3\u03ae\u03c2<\/li>\n\n\n\n<li><strong>\u03a3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c4\u03c1\u03b1\u03bd\u03c3\u03c0\u03bf\u03b6\u03bf\u03bd\u03af\u03c9\u03bd \/ mRNA<\/strong> (\u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc): \u039c\u03b7 \u03b5\u03bd\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03c3\u03b7 \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ce\u03bd \u03bb\u03cd\u03c3\u03b5\u03c9\u03bd<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0395\u03c0\u03ad\u03ba\u03c4\u03b1\u03c3\u03b7<\/strong><br>\u03a0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc\u03c2 \u03c4\u03c9\u03bd \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b1\u03b3\u03bc\u03ad\u03bd\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03b5\u03c0\u03af 7-14 \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2 \u03c3\u03b5 \u03c4\u03c5\u03c0\u03b9\u03ba\u03ac 10\u2078-10\u2079 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a0\u03bf\u03b9\u03bf\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2<\/strong><br>\u0394\u03bf\u03ba\u03b9\u03bc\u03ae \u03b3\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bc\u03b5\u03c4\u03b1\u03b3\u03c9\u03b3\u03ae\u03c2 CAR, \u03c3\u03c4\u03b5\u03b9\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1, \u03c5\u03c0\u03bf\u03bb\u03b5\u03b9\u03bc\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ac, \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf\u03c2 \u03a4-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03b9\u03c3\u03c7\u03cd\u03bf\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039a\u03c1\u03c5\u03bf\u03c3\u03c5\u03bd\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 &amp; \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac<\/strong><br>\u03c3\u03c4\u03bf \u03ba\u03ad\u03bd\u03c4\u03c1\u03bf \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039b\u03b5\u03bc\u03c6\u03bf\u03b1\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7<\/strong><br>\u039f \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 (\u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c6\u03bb\u03bf\u03c5\u03b4\u03b1\u03c1\u03b1\u03b2\u03af\u03bd\u03b7 + \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03c9\u03c3\u03c6\u03b1\u03bc\u03af\u03b4\u03b7) 2-7 \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2 \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ad\u03b3\u03c7\u03c5\u03c3\u03b7 CAR-T \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03bc\u03b5\u03b9\u03c9\u03b8\u03bf\u03cd\u03bd \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03b7\u03b8\u03b5\u03af \u201e\u03c7\u03ce\u03c1\u03bf\u03c2\u201c (\u03bb\u03b5\u03bc\u03c6\u03bf\u03b4\u03b5\u03c3\u03bc\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03b5\u03c4\u03bf\u03b9\u03bc\u03b1\u03c3\u03af\u03b1). \u0391\u03c5\u03c4\u03cc \u03c4\u03bf \u03b2\u03ae\u03bc\u03b1 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03bc\u03b1\u03b6\u03b9\u03ba\u03ac \u03c4\u03bf\u03bd \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03bc\u03bf\u03bd\u03ae \u03c4\u03c9\u03bd CAR-T \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03bf\u03bc\u03bf\u03b9\u03bf\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7\u03c2 IL-7\/IL-15.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0388\u03b3\u03c7\u03c5\u03c3\u03b7<\/strong><br>\u0395\u03bd\u03b9\u03b1\u03af\u03b1 \u03b5\u03bd\u03b4\u03bf\u03c6\u03bb\u03ad\u03b2\u03b9\u03b1 \u03ad\u03b3\u03c7\u03c5\u03c3\u03b7 CAR-T \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0397 \u03b5\u03c0\u03b9\u03c3\u03c4\u03ae\u03bc\u03b7 \u03c0\u03af\u03c3\u03c9 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03cc:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03bb\u03b5\u03bc\u03c6\u03bf\u03b1\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7\u03c2: <a href=\"https:\/\/www.nature.com\/articles\/nm1263\" target=\"_blank\" rel=\"noopener\">Gattinoni et al, Nature Medicine 2005<\/a><\/li>\n\n\n\n<li>\u0395\u03c0\u03b9\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae\u03c2: <a href=\"https:\/\/www.cell.com\/molecular-therapy-family\/molecular-therapy\/fulltext\/S1525-0016(16)45462-1\" target=\"_blank\" rel=\"noopener\">Levine et al, Molecular Therapy 2017<\/a><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wirkmechanismus_Effektorphase\"><\/span>\u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 &amp; \u03c6\u03ac\u03c3\u03b7 effector<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u039c\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03ad\u03b3\u03c7\u03c5\u03c3\u03b7, \u03c4\u03b1 CAR-T \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03bf \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf-\u03c3\u03c4\u03cc\u03c7\u03bf \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c4\u03b1 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03bf\u03c0\u03cc\u03c4\u03b5 \u03c3\u03c7\u03b7\u03bc\u03b1\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7: \u03a4\u03bf CAR \u03b4\u03b5\u03c3\u03bc\u03b5\u03cd\u03b5\u03b9 \u03c4\u03bf \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf \u2192 \u03c4\u03b1 CD3\u03b6-ITAM \u03c6\u03c9\u03c3\u03c6\u03bf\u03c1\u03c5\u03bb\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u2192 \u03ba\u03b1\u03c4\u03b1\u03c1\u03c1\u03ac\u03ba\u03c4\u03b7\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2 ZAP-70\/Lck \u2192 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 NF-\u03ba\u0392, NFAT, AP-1 \u2192 \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03ad\u03c1\u03c9\u03c3\u03b7 \u03c0\u03b5\u03c1\u03c6\u03bf\u03c1\u03af\u03bd\u03b7\u03c2\/\u03b3\u03c1\u03b1\u03bd\u03b6\u03cd\u03bc\u03bf\u03c5 \u0392 (\u03ac\u03bc\u03b5\u03c3\u03b7 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03cc\u03bb\u03c5\u03c3\u03b7) + IFN-\u03b3, TNF-\u03b1 (\u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1: <strong>\u0395\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b5\u03c5\u03c1\u03b9\u03c3\u03ba\u03cc\u03bc\u03b5\u03bd\u03bf\u03c5<\/strong> - \u03bf\u03b9 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03af\u03bd\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03b5\u03c1\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03ac\u03bb\u03bb\u03b1 \u03b5\u03bd\u03b4\u03bf\u03b3\u03b5\u03bd\u03ae \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03bf\u03c5\u03bd \u03c3\u03b5 \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03ad\u03c1\u03c9\u03c3\u03b7\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd (CRS).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0395\u03c0\u03b9\u03c3\u03c4\u03ae\u03bc\u03b7:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 CAR-T: <a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.aam8871\" target=\"_blank\" rel=\"noopener\">Lim &amp; June, \u0395\u03c0\u03b9\u03c3\u03c4\u03ae\u03bc\u03b7 2017<\/a><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"TCR-T-Zelltherapie_Die_entscheidenden_Unterschiede\"><\/span>\u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 TCR-T \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1: \u03bf\u03b9 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Warum_TCR_und_nicht_CAR_fur_intrazellulare_Antigene\"><\/span>\u0393\u03b9\u03b1\u03c4\u03af TCR \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 CAR \u03b3\u03b9\u03b1 \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03b1;<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f\u03b9 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 CAR \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03bc\u03cc\u03bd\u03bf <strong>\u0395\u03c0\u03b9\u03c6\u03b1\u03bd\u03b5\u03b9\u03b1\u03ba\u03ad\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2<\/strong>. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03bf\u03c5 \u03cc\u03c4\u03b9 \u03c4\u03b1 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03cc\u03b3\u03ba\u03bf \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03b1 \u03b5\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ac (\u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03b9\u03ba\u03bf\u03af \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2, \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ac \u03ad\u03bd\u03b6\u03c5\u03bc\u03b1, \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03b1 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03cc\u03c1\u03c7\u03b5\u03c9\u03bd \u03cc\u03c0\u03c9\u03c2 \u03c4\u03b1 PRAME, MAGE-A4), \u03b7 CAR-T \u03b8\u03b1 \u03ae\u03c4\u03b1\u03bd \u03c4\u03c5\u03c6\u03bb\u03ae \u03c3\u03b5 \u03b1\u03c5\u03c4\u03bf\u03cd\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c4\u03cc\u03c7\u03bf\u03c5\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f \u03c6\u03c5\u03c3\u03b9\u03ba\u03cc\u03c2 TCR \u03ad\u03c7\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bd\u03b1 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03b5\u03b9 \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03bf\u03b9 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c7\u03ce\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd <strong>\u03a0\u03c1\u03c9\u03c4\u03b5\u03ac\u03c3\u03c9\u03bc\u03b1<\/strong> \u03b1\u03c0\u03bf\u03b9\u03ba\u03bf\u03b4\u03bf\u03bc\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03b1 \u03bc\u03ae\u03ba\u03bf\u03c5\u03c2 ~8-11 \u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03ad\u03c9\u03bd. \u0391\u03c5\u03c4\u03ac \u03c4\u03b1 \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03b1 \u03b1\u03c0\u03bf\u03b9\u03ba\u03bf\u03b4\u03bf\u03bc\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03b5\u03bd\u03b4\u03bf\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03b4\u03af\u03ba\u03c4\u03c5\u03bf \u03c3\u03b5 <strong>\u039c\u03cc\u03c1\u03b9\u03b1 MHC \u03c4\u03ac\u03be\u03b7\u03c2 \u0399 (HLA \u03c3\u03c4\u03bf\u03bd \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf)<\/strong> \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u0395\u03ba\u03b5\u03af \u03b4\u03b5\u03c3\u03bc\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03b1\u03b2-TCR, \u03ad\u03bd\u03b1\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03bd\u03b5\u03c1\u03b3\u03cc\u03c2 \u03c3\u03b5 \u03cc\u03bb\u03b1 \u03c4\u03b1 \u03c0\u03c5\u03c1\u03b7\u03bd\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0397 \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03cc\u03ba\u03bb\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03bc\u03b5 TCR<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03bf\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2 HLA: \u03ad\u03bd\u03b1\u03c2 \u03c6\u03c5\u03c3\u03b9\u03ba\u03cc\u03c2 TCR \u03c5\u03c8\u03b7\u03bb\u03ae\u03c2 \u03c3\u03c5\u03b3\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03b5\u03b9 \u03ad\u03bd\u03b1 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03bc\u03cc\u03bd\u03bf \u03c3\u03c4\u03bf \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf \u03b5\u03bd\u03cc\u03c2 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b1\u03bb\u03bb\u03b7\u03bb\u03cc\u03bc\u03bf\u03c1\u03c6\u03bf\u03c5 HLA (\u03c0.\u03c7. HLA-A*02:01, \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 40-50 % \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c5\u03ba\u03ac\u03c3\u03b9\u03bf\u03c5 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03bf\u03cd). \u0391\u03c5\u03c4\u03cc \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03cc\u03c3\u03bf \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03bf\u03af \u03bc\u03b5 \u03c4\u03bf HLA \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03bf\u03af \u03c3\u03c4\u03bf\u03bd \u03cc\u03b3\u03ba\u03bf \u03b3\u03b9\u03b1 \u03c4\u03bf \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf-\u03c3\u03c4\u03cc\u03c7\u03bf.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Struktur_des_therapeutischen_TCR\"><\/span>\u0394\u03bf\u03bc\u03ae \u03c4\u03bf\u03c5 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03bf\u03cd TCR<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03bf\u03af TCRs \u03b5\u03af\u03bd\u03b1\u03b9 \u03c9\u03c2 \u03b5\u03c0\u03af \u03c4\u03bf \u03c0\u03bb\u03b5\u03af\u03c3\u03c4\u03bf\u03bd <strong>\u0395\u03c4\u03b5\u03c1\u03bf\u03b4\u03b9\u03bc\u03b5\u03c1\u03ae \u03b1\u03b2-TCR<\/strong>, \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0391\u03bd\u03b1\u03c0\u03c4\u03cd\u03c7\u03b8\u03b7\u03ba\u03b5 \u03bc\u03ad\u03c3\u03c9 phage display \u03ae \u03b5\u03be\u03b1\u03bd\u03b8\u03c1\u03c9\u03c0\u03b9\u03c3\u03bc\u03bf\u03cd \u03c3\u03b5 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03bc\u03b5 \u03b5\u03be\u03b1\u03b9\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03c5\u03c8\u03b7\u03bb\u03ae \u03c3\u03c5\u03b3\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 (KD \u03c3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae pM). \u039f \u03c6\u03c5\u03c3\u03b9\u03ba\u03cc\u03c2 TCR \u03ad\u03c7\u03b5\u03b9 \u03bc\u03cc\u03bd\u03bf \u03bc\u03ad\u03c4\u03c1\u03b9\u03b1 \u03c3\u03c5\u03b3\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 (\u03bc\u039c), \u03ba\u03b1\u03b8\u03ce\u03c2 \u03b7 \u03c0\u03bf\u03bb\u03cd \u03c5\u03c8\u03b7\u03bb\u03ae \u03c3\u03c5\u03b3\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03b8\u03b1 \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03c3\u03b5 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1.<\/li>\n\n\n\n<li>\u03a3\u03c4\u03b1\u03b8\u03b5\u03c1\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03b1\u03ba\u03bf\u03cd\u03c3\u03b9\u03b1\u03c2 \u03c3\u03cd\u03b6\u03b5\u03c5\u03be\u03b7\u03c2 \u03bc\u03b5 \u03b5\u03bd\u03b4\u03bf\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 TCR \u03bc\u03b5 \u03c5\u03c0\u03bf\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c0\u03bf\u03bd\u03c4\u03b9\u03ba\u03bf\u03cd \u03ae \u03b4\u03b9\u03c3\u03bf\u03c5\u03bb\u03c6\u03b9\u03b4\u03b9\u03ba\u03ad\u03c2 \u03b3\u03ad\u03c6\u03c5\u03c1\u03b5\u03c2<\/li>\n\n\n\n<li>\u03bd\u03b1 \u03b5\u03b9\u03c3\u03b1\u03c7\u03b8\u03b5\u03af \u03c3\u03c4\u03b1 \u03a4 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03af\u03b4\u03b9\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2 \u03bc\u03ad\u03c3\u03c9 lentiviral transduction<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0395\u03c0\u03b9\u03c3\u03c4\u03ae\u03bc\u03b7:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03ba\u03ae \u03c3\u03c5\u03b3\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2 TCR: <a href=\"https:\/\/www.jimmunol.org\/content\/180\/9\/6116\" target=\"_blank\" rel=\"noopener\">Robbins et al, Journal of Immunology 2008<\/a><\/li>\n\n\n\n<li>\u0395\u03c0\u03b9\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd TCR-T: <a href=\"https:\/\/aacrjournals.org\/cancerimmunolres\/article\/7\/8\/1236\/469286\" target=\"_blank\" rel=\"noopener\">Dangaj et al, Cancer Immunology Research 2019<\/a><\/li>\n\n\n\n<li>\u0392\u03ac\u03c3\u03b7 MAGE-A4 TCR \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd Tecelra: <a href=\"https:\/\/aacrjournals.org\/clincancerres\/article\/25\/24\/7537\/82286\" target=\"_blank\" rel=\"noopener\">Kageyama et al, Clin Cancer Research 2019<\/a><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"TIL-Therapie_%E2%80%93_Prinzip_der_naturlichen_Tumorerkennung\"><\/span>\u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 TIL - \u03b1\u03c1\u03c7\u03ae \u03c4\u03b7\u03c2 \u03c6\u03c5\u03c3\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Biologische_Grundlage\"><\/span>\u0392\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b2\u03ac\u03c3\u03b7<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f\u03b9 \u03cc\u03b3\u03ba\u03bf\u03b9 \u03b4\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2, \u03c4\u03b1 <strong>\u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd \u03c4\u03bf\u03bd \u03cc\u03b3\u03ba\u03bf (TIL)<\/strong>. \u0391\u03c5\u03c4\u03ac \u03c4\u03b1 \u03a4 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03ae\u03b4\u03b7 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03c3\u03b5\u03b9 \u03c4\u03bf\u03bd \u03cc\u03b3\u03ba\u03bf, \u03b1\u03bb\u03bb\u03ac \u03c3\u03c5\u03c7\u03bd\u03ac \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03be\u03b1\u03bd\u03c4\u03bb\u03b7\u03bc\u03ad\u03bd\u03b1, \u03b1\u03bd\u03b5\u03bd\u03b5\u03c1\u03b3\u03ac \u03ae \u03c0\u03bf\u03bb\u03cd \u03bb\u03af\u03b3\u03b1 \u03bb\u03cc\u03b3\u03c9 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03bf\u03cd \u03bc\u03b9\u03ba\u03c1\u03bf\u03c0\u03b5\u03c1\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd\u03c4\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5 (TME). \u0397 \u03c5\u03c8\u03b7\u03bb\u03ae \u03c0\u03c5\u03ba\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 TIL \u03c3\u03c4\u03bf\u03bd \u03cc\u03b3\u03ba\u03bf \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c0\u03c1\u03cc\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c3\u03b5 \u03c0\u03bf\u03bb\u03bb\u03bf\u03cd\u03c2 \u03c4\u03cd\u03c0\u03bf\u03c5\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03b9\u03b4\u03ad\u03b1 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 TIL (\u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c0\u03c4\u03cd\u03c7\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd Steven Rosenberg \u03c3\u03c4\u03bf NCI, Bethesda, \u03c4\u03b7 \u03b4\u03b5\u03ba\u03b1\u03b5\u03c4\u03af\u03b1 \u03c4\u03bf\u03c5 1980): \u03a0\u03ac\u03c1\u03c4\u03b5 \u03b1\u03c5\u03c4\u03ac \u03c4\u03b1 \u03ae\u03b4\u03b7 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03cc\u03b3\u03ba\u03bf \u03a4-\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03b5\u03c1\u03ce\u03c3\u03c4\u03b5 \u03c4\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03cc \u03c0\u03b5\u03c1\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd, \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03c4\u03b5 \u03ba\u03b1\u03b9 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03ac\u03c3\u03c4\u03b5 \u03c4\u03b1 \u03bc\u03b1\u03b6\u03b9\u03ba\u03ac ex vivo \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03ad\u03c8\u03c4\u03b5 \u03c4\u03b1 \u03c3\u03b5 \u03c4\u03cc\u03c3\u03bf \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf\u03c5\u03c2 \u03b1\u03c1\u03b9\u03b8\u03bc\u03bf\u03cd\u03c2 \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03cd\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c0\u03b1\u03c1\u03ac \u03c4\u03b7\u03bd \u03c4\u03ac\u03c3\u03b7 \u03b5\u03be\u03ac\u03bd\u03c4\u03bb\u03b7\u03c3\u03b7\u03c2.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Herstellungsprozess_Lifileucel\"><\/span>\u0394\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae\u03c2 (Lifileucel)<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0391\u03c6\u03b1\u03af\u03c1\u03b5\u03c3\u03b7 \u03cc\u03b3\u03ba\u03bf\u03c5<\/strong><br>\u03a4\u03bf\u03c5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03bf\u03bd 1,5 cm\u00b3 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03bf\u03cd \u03b9\u03c3\u03c4\u03bf\u03cd \u03b1\u03c6\u03b1\u03b9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c7\u03b5\u03b9\u03c1\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b5\u03be\u03b5\u03c1\u03b3\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03bc\u03ad\u03c3\u03c9\u03c2 \u03c3\u03b5 <a href=\"https:\/\/www.iovance.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">Iovance Biotherapeutics, Inc.<\/a> \u03ad\u03c3\u03c4\u03b5\u03b9\u03bb\u03b5.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0391\u03c1\u03c7\u03b9\u03ba\u03ae \u03b5\u03c0\u03ad\u03ba\u03c4\u03b1\u03c3\u03b7 (\u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 11 \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2)<\/strong><br>\u039f \u03cc\u03b3\u03ba\u03bf\u03c2 \u03b4\u03b9\u03b1\u03c7\u03c9\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03b5\u03bd\u03b6\u03c5\u03bc\u03b9\u03ba\u03ac- \u03bf\u03b9 TIL \u03ba\u03b1\u03bb\u03bb\u03b9\u03b5\u03c1\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 IL-2 \u2192 Pre-REP (Pre-Rapid Expansion Protocol).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a4\u03b1\u03c7\u03b5\u03af\u03b1 \u03b5\u03c0\u03ad\u03ba\u03c4\u03b1\u03c3\u03b7 (\u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 11 \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2)<\/strong><br>\u03a4\u03b1 TILs \u03c5\u03c0\u03bf\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03bf\u03c5 CD3 (OKT3), \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b2\u03bf\u03bb\u03b7\u03bc\u03ad\u03bd\u03b1 \u03b1\u03bb\u03bb\u03bf\u03b3\u03b5\u03bd\u03ae PBMCs (\u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b4\u03c1\u03bf\u03c5\u03bd \u03c9\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b3\u03bf\u03bd\u03bf\u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1) \u03ba\u03b1\u03b9 IL-2 \u03b3\u03b9\u03b1 <strong>&gt;7,5 \u00d7 10\u2079 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1<\/strong> \u03b5\u03c0\u03b5\u03ba\u03c4\u03b5\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 (\u03b1\u03c0\u03cc \u03bc\u03b5\u03c1\u03b9\u03ba\u03ac \u03b5\u03ba\u03b1\u03c4\u03bf\u03bc\u03bc\u03cd\u03c1\u03b9\u03b1 \u03c3\u03b5 \u03b4\u03b9\u03c3\u03b5\u03ba\u03b1\u03c4\u03bf\u03bc\u03bc\u03cd\u03c1\u03b9\u03b1).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039b\u03b5\u03bc\u03c6\u03bf\u03b1\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7 &amp; \u03ad\u03b3\u03c7\u03c5\u03c3\u03b7<\/strong><br>\u038a\u03b4\u03b9\u03bf \u03bc\u03b5 \u03c4\u03bf CAR-T: \u03c0\u03c1\u03bf\u03b5\u03c4\u03bf\u03b9\u03bc\u03b1\u03c3\u03af\u03b1 \u03bc\u03b5 Flu\/Cy, \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03b5\u03c6\u03ac\u03c0\u03b1\u03be \u03ad\u03b3\u03c7\u03c5\u03c3\u03b7 TIL, \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03b1\u03c0\u03cc \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 IL-2 \u03b3\u03b9\u03b1 \u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 in vivo \u03b5\u03c0\u03ad\u03ba\u03c4\u03b1\u03c3\u03b7.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a7\u03c1\u03bf\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf<\/strong><br>\u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ac \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b1\u03c6\u03b1\u03af\u03c1\u03b5\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5 \u03ad\u03c9\u03c2 \u03c4\u03b7\u03bd \u03ad\u03b3\u03c7\u03c5\u03c3\u03b7 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 6-7 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0395\u03c0\u03b9\u03c3\u03c4\u03ae\u03bc\u03b7:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u03a4\u03bf \u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc \u03ad\u03c1\u03b3\u03bf \u03c4\u03bf\u03c5 Rosenberg: <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJM198812223192529\" target=\"_blank\" rel=\"noopener\">Rosenberg et al, NEJM 1988<\/a><\/li>\n\n\n\n<li>Lifileucel \u03a6\u03ac\u03c3\u03b7\u03c2 2 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ae \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 (C-144-01): <a href=\"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.21.02179\" target=\"_blank\" rel=\"noopener\">Chesney et al, JCO 2022<\/a><\/li>\n\n\n\n<li>\u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 5 \u03b5\u03c4\u03ce\u03bd: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40699950\/\" target=\"_blank\" rel=\"noopener\">\u03a3\u03cd\u03bd\u03bf\u03c8\u03b7 \u03ad\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 FDA 2024<\/a><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Herausforderungen_%E2%80%93_aktuelle_Forschungsansatze\"><\/span>\u03a0\u03c1\u03bf\u03ba\u03bb\u03ae\u03c3\u03b5\u03b9\u03c2 - \u03c4\u03c1\u03ad\u03c7\u03bf\u03c5\u03c3\u03b5\u03c2 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03bf\u03c3\u03b5\u03b3\u03b3\u03af\u03c3\u03b5\u03b9\u03c2<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Antigen-Escape\"><\/span>\u0391\u03c0\u03cc\u03b4\u03c1\u03b1\u03c3\u03b7 \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf\u03c5<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039f\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03bf\u03b2\u03bb\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2<\/strong><br>\u03a4\u03b1 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03c3\u03bf\u03c5\u03bd \u03ae \u03bd\u03b1 \u03c7\u03ac\u03c3\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf\u03c5-\u03c3\u03c4\u03cc\u03c7\u03bf\u03c5. \u03a3\u03c4\u03bf CD19-CAR-T, CD19-\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 30-40 % \u03c4\u03c9\u03bd \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03c9\u03bd.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039b\u03cd\u03c3\u03b7<\/strong><br>\u03a3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b9\u03c0\u03bb\u03ae\u03c2 \u03c3\u03c4\u03cc\u03c7\u03b5\u03c5\u03c3\u03b7\u03c2 (CD19+CD22, BCMA+CD38), tandem CARs, CARs \u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03c0\u03cd\u03bb\u03b7\u03c2 (\u03c0\u03cd\u03bb\u03b7 AND: \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd \u03b4\u03cd\u03bf \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03b1- \u03c0\u03cd\u03bb\u03b7 NOT: \u03c3\u03ba\u03bf\u03c4\u03ce\u03bd\u03bf\u03c5\u03bd \u03bc\u03cc\u03bd\u03bf \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf).<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.nature.com\/articles\/nm.4164\" target=\"_blank\" rel=\"noopener\">Ruella et al, Nature Medicine 2016 (CD19-Escape)<\/a><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"T-Zell-Erschopfung_Exhaustion\"><\/span>\u0395\u03be\u03ac\u03bd\u03c4\u03bb\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03a4-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (\u03b5\u03be\u03ac\u03bd\u03c4\u03bb\u03b7\u03c3\u03b7)<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039f\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03bf\u03b2\u03bb\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2<\/strong><br>\u03a4\u03b1 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03c3\u03bf\u03c5\u03bd \u03ae \u03bd\u03b1 \u03c7\u03ac\u03c3\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf\u03c5-\u03c3\u03c4\u03cc\u03c7\u03bf\u03c5. \u03a3\u03c4\u03bf CD19-CAR-T, CD19-\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 30-40 % \u03c4\u03c9\u03bd \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03c9\u03bd.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03ad\u03ba\u03b8\u03b5\u03c3\u03b7 \u03c3\u03b5 \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03b1 \u2192 \u0388\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03b4\u03b5\u03b9\u03ba\u03c4\u03ce\u03bd \u03b5\u03be\u03ac\u03bd\u03c4\u03bb\u03b7\u03c3\u03b7\u03c2 (PD-1, TIM-3, LAG-3, \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03b9\u03ba\u03cc\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 TOX) \u2192 \u0391\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039b\u03cd\u03c3\u03b7:<\/strong> \u03a3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03bc\u03b5 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03c9\u03bd \u03c3\u03b7\u03bc\u03b5\u03af\u03c9\u03bd \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5, \u03b5\u03c0\u03b9\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b5\u03c0\u03b1\u03bd\u03b1\u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03cc\u03c2 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u03c4\u03bf\u03c5 TET2, \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03bf\u03af CAR \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03b7\u03c2 \u03b3\u03b5\u03bd\u03b9\u03ac\u03c2 \u03bc\u03b5 \u03b5\u03bd\u03c3\u03c9\u03bc\u03b1\u03c4\u03c9\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03bc\u03cc \u03c4\u03c9\u03bd \u03c3\u03b7\u03bc\u03b5\u03af\u03c9\u03bd \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41586-019-1546-z\" target=\"_blank\" rel=\"noopener\">Chen et al, Nature 2019 (TET2 knockdown)<\/a><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Tumormikroumgebung_TME\"><\/span>\u039c\u03b9\u03ba\u03c1\u03bf\u03c0\u03b5\u03c1\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5 (TME)<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039f\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03bf\u03b2\u03bb\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2<\/strong><br>\u03a4\u03b1 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03c3\u03bf\u03c5\u03bd \u03ae \u03bd\u03b1 \u03c7\u03ac\u03c3\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf\u03c5-\u03c3\u03c4\u03cc\u03c7\u03bf\u03c5. \u03a3\u03c4\u03bf CD19-CAR-T, CD19-\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 30-40 % \u03c4\u03c9\u03bd \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03c9\u03bd.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f\u03b9 \u03c3\u03c5\u03bc\u03c0\u03b1\u03b3\u03b5\u03af\u03c2 \u03cc\u03b3\u03ba\u03bf\u03b9 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03c7\u03b8\u03c1\u03b9\u03ba\u03cc \u03bc\u03b9\u03ba\u03c1\u03bf\u03c0\u03b5\u03c1\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd: \u03c5\u03c0\u03bf\u03be\u03af\u03b1, \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7\u03c2, \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ad\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03af\u03bd\u03b5\u03c2 (TGF-\u03b2, IL-10), Tregs, MDSCs.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039b\u03cd\u03c3\u03b7<\/strong><br>\u0398\u03c9\u03c1\u03b1\u03ba\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 CARs \u03bc\u03b5 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 IL-12\/IL-15\/IL-18, CARs \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf PD-1, \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03bc\u03b5 anti-VEGF, \u03c4\u03bf\u03c0\u03b9\u03ba\u03ad\u03c2 \u03b5\u03bd\u03b4\u03bf\u03bf\u03b3\u03ba\u03b9\u03ba\u03ad\u03c2 \u03b5\u03bd\u03ad\u03c3\u03b5\u03b9\u03c2.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41598-017-10259-0\" target=\"_blank\" rel=\"noopener\">Yeku et al, Scientific Reports 2017 (\u0398\u03c9\u03c1\u03b1\u03ba\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b1\u03c5\u03c4\u03bf\u03ba\u03af\u03bd\u03b7\u03c4\u03bf)<\/a><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Zytokinsturm_CRS_ICANS\"><\/span>\u039a\u03b1\u03c4\u03b1\u03b9\u03b3\u03af\u03b4\u03b1 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd (CRS) &amp; ICANS<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039f\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03bf\u03b2\u03bb\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2<\/strong><br>\u03a4\u03bf CRS \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03bc\u03b1\u03b6\u03b9\u03ba\u03ae \u03b1\u03c0\u03b5\u03bb\u03b5\u03c5\u03b8\u03ad\u03c1\u03c9\u03c3\u03b7 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd (IL-6, IFN-\u03b3, IL-1\u03b2) \u03b1\u03c0\u03cc \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b1 CAR-T \u03ba\u03b1\u03b9 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c6\u03ac\u03b3\u03b1. \u03a4\u03bf \u03c3\u03bf\u03b2\u03b1\u03c1\u03cc CRS (\u03b2\u03b1\u03b8\u03bc\u03cc\u03c2 3-4) \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03b5\u03bd\u03c4\u03b1\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1. \u0397 ICANS (\u03bd\u03b5\u03c5\u03c1\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1) \u03c0\u03c1\u03bf\u03ba\u03cd\u03c0\u03c4\u03b5\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b4\u03bf\u03b8\u03b7\u03bb\u03af\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03b9\u03ba\u03bf\u03cd \u03c6\u03c1\u03b1\u03b3\u03bc\u03bf\u03cd.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0394\u03b9\u03b1\u03c7\u03b5\u03af\u03c1\u03b9\u03c3\u03b7<\/strong><br>Tocilizumab (\u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03bc\u03cc\u03c2 IL-6R), \u03ba\u03bf\u03c1\u03c4\u03b9\u03ba\u03bf\u03c3\u03c4\u03b5\u03c1\u03bf\u03b5\u03b9\u03b4\u03ae, anakinra (\u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03bc\u03cc\u03c2 IL-1)- \u03b7 \u03ad\u03b3\u03ba\u03b1\u03b9\u03c1\u03b7 \u03c0\u03b1\u03c1\u03ad\u03bc\u03b2\u03b1\u03c3\u03b7 \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4116524\/\" target=\"_blank\" rel=\"noopener\">Lee et al, Blood 2014 - \u03a3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03c4\u03b1\u03be\u03b9\u03bd\u03cc\u03bc\u03b7\u03c3\u03b7\u03c2 CRS<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.nature.com\/articles\/nrneurol.2018.138\" target=\"_blank\" rel=\"noopener\">Neelapu et al, Nature Reviews Neurology 2018 - ICANS<\/a><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Allogene_%E2%80%9EOff-the-shelf%E2%80%9C-Therapien\"><\/span>\u0391\u03bb\u03bb\u03bf\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u201e\u03ad\u03c4\u03bf\u03b9\u03bc\u03b5\u03c2\u201c \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039f\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03bf\u03b2\u03bb\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2<\/strong><br>\u03a4\u03b1 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03c3\u03bf\u03c5\u03bd \u03ae \u03bd\u03b1 \u03c7\u03ac\u03c3\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf\u03c5-\u03c3\u03c4\u03cc\u03c7\u03bf\u03c5. \u03a3\u03c4\u03bf CD19-CAR-T, CD19-\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 30-40 % \u03c4\u03c9\u03bd \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03c9\u03bd.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03b1\u03c5\u03c4\u03cc\u03bb\u03bf\u03b3\u03b7 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b4\u03b9\u03b1\u03c1\u03ba\u03b5\u03af 3-6 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03b1\u03c0\u03b1\u03bd\u03b7\u03c1\u03ae (400.000-600.000 \u20ac).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039b\u03cd\u03c3\u03b7<\/strong><br>\u0391\u03bb\u03bb\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 CAR-T \u03b1\u03c0\u03cc \u03c5\u03b3\u03b9\u03b5\u03af\u03c2 \u03b4\u03cc\u03c4\u03b5\u03c2, \u03bc\u03b5 CRISPR knockout \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b4\u03bf\u03b3\u03b5\u03bd\u03bf\u03cd\u03c2 TCR (\u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 GvHD) \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd HLA (\u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03b1\u03c0\u03cc\u03c1\u03c1\u03b9\u03c8\u03b7\u03c2).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a4\u03c1\u03ad\u03c7\u03bf\u03bd\u03c4\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1<\/strong><br>\u03a4\u03bf CTX112 (CRISPR-\u03b1\u03bb\u03bb\u03bf\u03b3\u03b5\u03bd\u03ad\u03c2 CD19-CAR-T) \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03b9 \u03c4\u03b9\u03c2 \u03c0\u03c1\u03ce\u03c4\u03b5\u03c2 \u03c0\u03bb\u03ae\u03c1\u03b5\u03b9\u03c2 \u03c5\u03c6\u03ad\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03b7 \u03a7\u039b\u039b \u03c3\u03c4\u03b7 \u03c6\u03ac\u03c3\u03b7 1.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.abb4845\" target=\"_blank\" rel=\"noopener\">Stadtmauer et al, Science 2020 - CRISPR CAR-T \u03a6\u03ac\u03c3\u03b7 1<\/a><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"27_Quantitative_Wirksamkeitsdaten_im_Uberblick\"><\/span>2.7 \u03a0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03ac \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03bc\u03b5 \u03bc\u03b9\u03b1 \u03bc\u03b1\u03c4\u03b9\u03ac<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1<\/th><th>\u0388\u03bd\u03b4\u03b5\u03b9\u03be\u03b7<\/th><th>ORR<\/th><th>\u03a0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc CR<\/th><th>\u0394\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 OS<\/th><th>\u03a0\u03b7\u03b3\u03ae<\/th><\/tr><\/thead><tbody><tr><td>Tisagenlecleucel<\/td><td>B-ALL \u03c0\u03b1\u03b9\u03b4\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae<\/td><td>81 %<\/td><td>60 %<\/td><td>NR (63 % \u03c3\u03b5 12 \u03bc\u03ae\u03bd\u03b5\u03c2)<\/td><td>NEJM 2018<\/td><\/tr><tr><td>Axicabtagene-cel<\/td><td>DLBCL 3\u03b7\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae\u03c2<\/td><td>83 %<\/td><td>58 %<\/td><td>NR (74 % \u03c3\u03b5 12 \u03bc\u03ae\u03bd\u03b5\u03c2)<\/td><td>NEJM 2017<\/td><\/tr><tr><td>Ciltacabtagene-cel<\/td><td>Mult. \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1<\/td><td>98 %<\/td><td>78 %<\/td><td>NR (&gt;80 % \u03c3\u03b5 12 \u03bc\u03ae\u03bd\u03b5\u03c2)<\/td><td>Lancet 2021<\/td><\/tr><tr><td>Lifileucel<\/td><td>\u039c\u03b5\u03bb\u03ac\u03bd\u03c9\u03bc\u03b1<\/td><td>31,4 %<\/td><td>7,5 %<\/td><td>NR (49 % \u03c3\u03b5 24 \u03bc\u03ae\u03bd\u03b5\u03c2)<\/td><td>JCO 2022<\/td><\/tr><tr><td>Afamitresgene-cel<\/td><td>\u03a3\u03c5\u03bd\u03b4\u03b5\u03c3\u03bc\u03b9\u03ba\u03cc \u03c3\u03ac\u03c1\u03ba\u03c9\u03bc\u03b1<\/td><td>43 %<\/td><td>4 %<\/td><td>16,4 \u03bc\u03ae\u03bd\u03b5\u03c2<\/td><td>Lancet 2024<\/td><\/tr><tr><td>Tebentafusp<\/td><td>\u039c\u03b5\u03bb\u03ac\u03bd\u03c9\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03c9\u03c7\u03c1\u03bf\u03cd \u03c6\u03b1\u03ba\u03bf\u03cd<\/td><td>9 % (ORR)<\/td><td>&lt;1 %<\/td><td>21,7 \u03bc\u03ae\u03bd\u03b5\u03c2<\/td><td>NEJM 2021<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><em>(NR = \u0394\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b5\u03c0\u03b9\u03c4\u03b5\u03c5\u03c7\u03b8\u03b5\u03af- OS* \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b5\u03c0\u03b9\u03c4\u03b5\u03c5\u03c7\u03b8\u03b5\u03af \u03b1\u03ba\u03cc\u03bc\u03b7)<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">*<em>OS<\/em> (<em>\u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7<\/em>\u00a0) - \u03c0.\u03c7. \u201e<em>\u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 OS 21,7<\/em>\u201e \u03cc\u03c4\u03b9 \u03bf\u03b9 \u03bc\u03b9\u03c3\u03bf\u03af \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03b5\u03af\u03c7\u03b1\u03bd \u03c0\u03b5\u03b8\u03ac\u03bd\u03b5\u03b9 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc 21,7 \u03bc\u03ae\u03bd\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03ac\u03bb\u03bb\u03bf\u03b9 \u03bc\u03b9\u03c3\u03bf\u03af \u03ae\u03c4\u03b1\u03bd \u03b1\u03ba\u03cc\u03bc\u03b7 \u03b6\u03c9\u03bd\u03c4\u03b1\u03bd\u03bf\u03af<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Weiterfuhrende_Literatur_Ressourcen\"><\/span>\u03a0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 &amp; \u03c0\u03cc\u03c1\u03bf\u03b9<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039a\u03c1\u03b9\u03c4\u03b9\u03ba\u03ad\u03c2:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.aar6711\" target=\"_blank\" rel=\"noopener\">June et al, Science 2018 - \u0395\u03c0\u03b9\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 CAR-T<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00428-019-02571-3\" target=\"_blank\" rel=\"noopener\">Rohaan et al, Virchows Arch 2019 - \u0391\u03bd\u03b1\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 TIL<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41586-019-1840-9\" target=\"_blank\" rel=\"noopener\">Stadtmauer et al, Nature 2020 - \u0391\u03bb\u03bb\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 TCR\/CAR-T<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039a\u03b1\u03c4\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae\u03c1\u03b9\u03b5\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ad\u03c2 &amp; \u03b2\u03ac\u03c3\u03b5\u03b9\u03c2 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/clinicaltrials.gov\/search?term=CAR-T+OR+TIL+OR+TCR-T&amp;recency=5\" target=\"_blank\" rel=\"noopener\">ClinicalTrials.gov - \u03cc\u03bb\u03b5\u03c2 \u03bf\u03b9 \u03b5\u03bd \u03b5\u03be\u03b5\u03bb\u03af\u03be\u03b5\u03b9 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.cancer.gov\/about-cancer\/treatment\/types\/immunotherapy\/t-cell-transfer-therapy\" target=\"_blank\" rel=\"noopener\">NCI - \u0395\u03c0\u03b9\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 \u03b1\u03bd\u03bf\u03c3\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.dgho.de\/informationen\/stellungnahmen\/gute-wissenschaftliche-praxis\/car-t-zellen\" target=\"_blank\" rel=\"noopener\">\u0393\u03b5\u03c1\u03bc\u03b1\u03bd\u03b9\u03ba\u03ae \u0395\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b1 \u0391\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 (DGHO) - \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 CAR-T<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a0\u03b7\u03b3\u03ad\u03c2 \u03c6\u03b9\u03bb\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03bf\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae (\u03b3\u03b5\u03c1\u03bc\u03b1\u03bd\u03b9\u03ba\u03ac):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.krebshilfe.de\/informieren\/ueber-krebs\/therapie\/immuntherapie\/\" target=\"_blank\" rel=\"noopener\">Krebshilfe Deutschland - \u0391\u03bd\u03bf\u03c3\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b5\u03be\u03b7\u03b3\u03b5\u03af\u03c4\u03b1\u03b9<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.kitz-heidelberg.de\/forschungsprogramme\/zell-und-gentherapie\/\" target=\"_blank\" rel=\"noopener\">KiTZ Heidelberg - \u0391\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 &amp; \u03b1\u03bd\u03bf\u03c3\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1<\/a><\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\"><em>\u03a3\u03b5 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b1\u03c0\u03cc \u03bc\u03b9\u03b1 \u03b4\u03b5\u03ba\u03b1\u03b5\u03c4\u03af\u03b1, \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03ba\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf \u03ac\u03bb\u03bc\u03b1 \u03b1\u03c0\u03cc \u03bc\u03b9\u03b1 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b9\u03b4\u03ad\u03b1 \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03c4\u03c5\u03c0\u03b9\u03ba\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 - \u03bc\u03b5 \u03c4\u03bf\u03bd \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc \u03c4\u03c9\u03bd \u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03c9\u03bd \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03c9\u03bd \u03bd\u03b1 \u03c3\u03c5\u03bd\u03b5\u03c7\u03af\u03b6\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b1\u03c7\u03b5\u03af\u03c2 \u03c1\u03c5\u03b8\u03bc\u03bf\u03cd\u03c2. \u0393\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03b9\u03bb\u03ad\u03be\u03b9\u03bc\u03bf\u03b9, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03bc\u03cc\u03bd\u03b7 \u03b4\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae.<\/em><\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Weltweit_zugelassene_Immunzelltherapien\"><\/span>\u03a0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u039a\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 02.2026<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Einleitung_Die_drei_grosen_Klassen\"><\/span>\u0395\u03b9\u03c3\u03b1\u03b3\u03c9\u03b3\u03ae: \u039f\u03b9 \u03c4\u03c1\u03b5\u03b9\u03c2 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b5\u03c2 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03ae\u03bc\u03b5\u03c1\u03b1, \u03bf \u03cc\u03c1\u03bf\u03c2 \u201e\u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u201c \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03b9 \u03c4\u03c1\u03b5\u03b9\u03c2 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03c9\u03bd \u03c3\u03c4\u03bf \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1. \u039a\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 CAR-T<\/strong> (\u039a\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03a4-\u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c7\u03b9\u03bc\u03b1\u03b9\u03c1\u03b9\u03ba\u03bf\u03cd \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf\u03c5)<br>\u0393\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ac \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b1 \u03a4-\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bc\u03b5 \u03c3\u03c5\u03bd\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03b5\u03c0\u03b9\u03c6\u03b1\u03bd\u03b5\u03b9\u03b1\u03ba\u03cc \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03b5\u03b9 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u038c\u03bb\u03b1 \u03c4\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03b3\u03ba\u03c1\u03b9\u03b8\u03b5\u03af \u03bc\u03ad\u03c7\u03c1\u03b9 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03c3\u03c4\u03c1\u03ad\u03c6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac \u03c4\u03bf\u03c5 CD19 \u03ae \u03c4\u03bf\u03c5 BCMA \u03ba\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 \u03b3\u03b9\u03b1 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>2. TCR-T \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1<\/strong> (\u03a4-\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03bf\u03af \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03a4-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd)<br>\u0393\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ac \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b1 \u03a4-\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bc\u03b5 \u03b2\u03b5\u03bb\u03c4\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf \u03c6\u03c5\u03c3\u03b9\u03ba\u03cc \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03a4-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03b5\u03b9 \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03cc\u03b3\u03ba\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03c3\u03cd\u03bc\u03c0\u03bb\u03b5\u03b3\u03bc\u03b1 HLA. \u03a0\u03c1\u03ce\u03c4\u03b7 \u03ad\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c3\u03c5\u03bc\u03c0\u03b1\u03b3\u03b5\u03af\u03c2 \u03cc\u03b3\u03ba\u03bf\u03c5\u03c2 \u03c4\u03bf 2024.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>3\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 TIL<\/strong> (\u039b\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b5\u03b9\u03c3\u03b4\u03cd\u03bf\u03c5\u03bd \u03c3\u03c4\u03bf\u03bd \u03cc\u03b3\u03ba\u03bf)<br>\u039c\u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ac \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b1 \u03a4-\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03cc\u03b3\u03ba\u03bf \u03c4\u03bf\u03c5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2, \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b1\u03b6\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b1\u03bd\u03b1\u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9. \u03a0\u03c1\u03ce\u03c4\u03b7 \u03ad\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03bc\u03b5\u03bb\u03ac\u03bd\u03c9\u03bc\u03b1 \u03c4\u03bf 2024.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039c\u03ad\u03c7\u03c1\u03b9 \u03c4\u03bf\u03bd \u0394\u03b5\u03ba\u03ad\u03bc\u03b2\u03c1\u03b9\u03bf \u03c4\u03bf\u03c5 2024, \u03bf FDA \u03b5\u03af\u03c7\u03b5 \u03b5\u03b3\u03ba\u03c1\u03af\u03bd\u03b5\u03b9 \u03ad\u03be\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 CAR-T \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03b5\u03bd\u03ce \u03b4\u03ad\u03ba\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 CAR-T \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ae\u03c4\u03b1\u03bd \u03b5\u03bc\u03c0\u03bf\u03c1\u03b9\u03ba\u03ac \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03b5\u03c2 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2. \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 TIL (Lifileucel) \u03ba\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 TCR (Afamitresgene autoleucel) - \u03bf\u03b9 \u03c0\u03c1\u03ce\u03c4\u03b5\u03c2 \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03b3\u03b9\u03b1 \u03c3\u03c5\u03bc\u03c0\u03b1\u03b3\u03b5\u03af\u03c2 \u03cc\u03b3\u03ba\u03bf\u03c5\u03c2. <a href=\"https:\/\/www.curemelanoma.org\/blog\/melanoma-clinical-trials-to-watch-fall-2025\" target=\"_blank\" rel=\"noreferrer noopener\">MRA<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"CAR-T-ZELLTHERAPIEN\"><\/span>\u039a\u03a5\u03a4\u03a4\u0391\u03a1\u0399\u039a\u0388\u03a3 \u0398\u0395\u03a1\u0391\u03a0\u0395\u038a\u0395\u03a3 CAR-T<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Tisagenlecleucel_Kymriah%C2%AE_%E2%80%93_Novartis\"><\/span>Tisagenlecleucel (Kymriah\u00ae) - <em>Novartis<\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0391\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf-\u03c3\u03c4\u03cc\u03c7\u03bf\u03c2:<\/strong> CD19 <br><strong>\u0395\u03be\u03bf\u03c5\u03c3\u03b9\u03bf\u03b4\u03bf\u03c4\u03ae\u03b8\u03b7\u03ba\u03b5:<\/strong> FDA 2017 \/ EMA 2018<br><strong>\u03a4\u03bf \u03c0\u03c1\u03ce\u03c4\u03bf CAR-T \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd \u03c0\u03bf\u03c5 \u03b5\u03b3\u03ba\u03c1\u03af\u03b8\u03b7\u03ba\u03b5 \u03c0\u03bf\u03c4\u03ad \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0395\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u03a0\u03b1\u03b9\u03b4\u03b9\u03ac \u03ba\u03b1\u03b9 \u03bd\u03b5\u03b1\u03c1\u03bf\u03af \u03b5\u03bd\u03ae\u03bb\u03b9\u03ba\u03b5\u03c2 \u03ad\u03c9\u03c2 25 \u03b5\u03c4\u03ce\u03bd: \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03bf\u03c5\u03c3\u03b1\/\u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae ALL \u0392-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (\u03bf\u03be\u03b5\u03af\u03b1 \u03bb\u03b5\u03bc\u03c6\u03bf\u03b2\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03bb\u03b5\u03c5\u03c7\u03b1\u03b9\u03bc\u03af\u03b1)<\/li>\n\n\n\n<li>\u0395\u03bd\u03ae\u03bb\u03b9\u03ba\u03b5\u03c2: \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03bf\u03bd\/\u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc \u03bb\u03ad\u03bc\u03c6\u03c9\u03bc\u03b1 \u03bc\u03b5\u03b3\u03ac\u03bb\u03c9\u03bd \u0392-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (LBCL) \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u22652 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2<\/li>\n\n\n\n<li>\u03a5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03bf\u03bd\/\u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc \u03bf\u03b6\u03ce\u03b4\u03b5\u03c2 \u03bb\u03ad\u03bc\u03c6\u03c9\u03bc\u03b1 (FL)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u039c\u03b5\u03bb\u03ad\u03c4\u03b7 ELIANA (ALL \u03c0\u03b1\u03b9\u03b4\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae): <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT02435849\" target=\"_blank\" rel=\"noopener\">NCT02435849<\/a> | <a href=\"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.21.01019\" target=\"_blank\" rel=\"noopener\">JCO 2021<\/a><\/li>\n\n\n\n<li>\u039c\u03b5\u03bb\u03ad\u03c4\u03b7 JULIET (LBCL): <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT02445248\" target=\"_blank\" rel=\"noopener\">NCT02445248<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0391\u03b4\u03b5\u03b9\u03bf\u03b4\u03bf\u03c4\u03bf\u03cd\u03c3\u03b5\u03c2 \u03b1\u03c1\u03c7\u03ad\u03c2<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>FDA<\/li>\n\n\n\n<li>EMA<\/li>\n\n\n\n<li>TGA (\u0391\u03c5\u03c3\u03c4\u03c1\u03b1\u03bb\u03af\u03b1)<\/li>\n\n\n\n<li>PMDA (\u0399\u03b1\u03c0\u03c9\u03bd\u03af\u03b1) <\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039a\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae\u03c2\/\u0399\u03c3\u03c4\u03bf\u03c3\u03b5\u03bb\u03af\u03b4\u03b1:<\/strong> <a href=\"https:\/\/www.novartis.com\/us-en\/sites\/novartis_us\/files\/kymriah.pdf\" target=\"_blank\" rel=\"noopener\">Novartis Kymriah<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a3\u03b5\u03bb\u03af\u03b4\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03bf\u03c2 FDA:<\/strong> <a href=\"https:\/\/www.fda.gov\/vaccines-blood-biologics\/kymriah\" target=\"_blank\" rel=\"noopener\">FDA Kymriah<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Axicabtagene_Ciloleucel_Yescarta%C2%AE_%E2%80%93_KiteGilead\"><\/span>Axicabtagene Ciloleucel (Yescarta\u00ae) - <em>Kite\/Gilead<\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0391\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf-\u03c3\u03c4\u03cc\u03c7\u03bf\u03c2:<\/strong> CD19<br><strong>\u0395\u03be\u03bf\u03c5\u03c3\u03b9\u03bf\u03b4\u03bf\u03c4\u03ae\u03b8\u03b7\u03ba\u03b5:<\/strong> FDA \u039f\u03ba\u03c4\u03ce\u03b2\u03c1\u03b9\u03bf\u03c2 2017 \/ EMA \u0391\u03cd\u03b3\u03bf\u03c5\u03c3\u03c4\u03bf\u03c2 2018<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0395\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u039b\u03ad\u03bc\u03c6\u03c9\u03bc\u03b1 \u03bc\u03b5\u03b3\u03ac\u03bb\u03c9\u03bd \u0392-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (DLBCL, PMBCL, HGBCL, tFL) \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u22652 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2<\/li>\n\n\n\n<li>\u03a0\u03c1\u03c9\u03c4\u03bf\u03c0\u03b1\u03b8\u03ad\u03c2 \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc DLBCL \u03ae \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae \u03b5\u03bd\u03c4\u03cc\u03c2 12 \u03bc\u03b7\u03bd\u03ce\u03bd (2\u03b7 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae)<\/li>\n\n\n\n<li>\u03a5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03bf\u03bd\/\u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc \u03bf\u03b6\u03ce\u03b4\u03b5\u03c2 \u03bb\u03ad\u03bc\u03c6\u03c9\u03bc\u03b1 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u22652 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>ZUMA-1 (LBCL, ORR 82 %): <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT02348216\" target=\"_blank\" rel=\"noopener\">NCT02348216<\/a> | <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1707447\" target=\"_blank\" rel=\"noopener\">NEJM 2017<\/a><\/li>\n\n\n\n<li>ZUMA-7 (2\u03b7\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae\u03c2 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 ASCT): <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03391466\" target=\"_blank\" rel=\"noopener\">NCT03391466<\/a><\/li>\n\n\n\n<li>ZUMA-5 (\u03bf\u03b6\u03ce\u03b4\u03b5\u03c2 \u03bb\u03ad\u03bc\u03c6\u03c9\u03bc\u03b1, ORR &gt;90 %): <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03105336\" target=\"_blank\" rel=\"noopener\">NCT03105336<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039a\u03ad\u03bd\u03c4\u03c1\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 (\u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae D\/A\/CH)<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u038c\u03bb\u03b1 \u03c4\u03b1 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03ad\u03bd\u03c4\u03c1\u03b1 \u03bc\u03b5\u03c4\u03b1\u03bc\u03bf\u03c3\u03c7\u03b5\u03cd\u03c3\u03b5\u03c9\u03bd FACT\/JACIE- \u03c3\u03c4\u03b7 \u0393\u03b5\u03c1\u03bc\u03b1\u03bd\u03af\u03b1, \u03c0.\u03c7. \u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03b9\u03b1\u03ba\u03cc \u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03cc \u039a\u03ad\u03bd\u03c4\u03c1\u03bf \u0391\u03bc\u03b2\u03bf\u03cd\u03c1\u03b3\u03bf\u03c5-Eppendorf, Charit\u00e9 \u0392\u03b5\u03c1\u03bf\u03bb\u03af\u03bd\u03bf\u03c5, LMU Klinikum M\u00fcnchen, \u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03b9\u03b1\u03ba\u03cc \u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03cc \u039a\u03ad\u03bd\u03c4\u03c1\u03bf \u03a7\u03b1\u03ca\u03b4\u03b5\u03bb\u03b2\u03ad\u03c1\u03b3\u03b7\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039a\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae\u03c2\/\u0399\u03c3\u03c4\u03bf\u03c3\u03b5\u03bb\u03af\u03b4\u03b1<\/strong>: <a href=\"https:\/\/www.yescarta.com\" target=\"_blank\" rel=\"noopener\">Gilead Yescarta<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Brexucabtagene_Autoleucel_Tecartus%C2%AE_%E2%80%93_KiteGilead\"><\/span>Brexucabtagene Autoleucel (Tecartus\u00ae) - <em>Kite\/Gilead<\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0391\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf-\u03c3\u03c4\u03cc\u03c7\u03bf\u03c2:<\/strong> CD19<br><strong>\u0395\u03be\u03bf\u03c5\u03c3\u03b9\u03bf\u03b4\u03bf\u03c4\u03ae\u03b8\u03b7\u03ba\u03b5:<\/strong> FDA \u0399\u03bf\u03cd\u03bb\u03b9\u03bf\u03c2 2020 (MCL), \u039f\u03ba\u03c4\u03ce\u03b2\u03c1\u03b9\u03bf\u03c2 2021 (ALL adult) \/ EMA \u0394\u03b5\u03ba\u03ad\u03bc\u03b2\u03c1\u03b9\u03bf\u03c2 2020<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0395\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u03a5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03bf\u03bd\/\u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc \u03bb\u03ad\u03bc\u03c6\u03c9\u03bc\u03b1 \u03b1\u03c0\u03cc \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03bc\u03b1\u03bd\u03b4\u03cd\u03b1 (MCL) \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1 BTK<\/li>\n\n\n\n<li>\u0395\u03bd\u03ae\u03bb\u03b9\u03ba\u03b5\u03c2 \u03bc\u03b5 \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03bf\u03c5\u03c3\u03b1\/\u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae ALL \u0392-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>ZUMA-2 (MCL, OS 12 \u03bc\u03ae\u03bd\u03b5\u03c2: 83 %): <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT02601313\" target=\"_blank\" rel=\"noopener\">NCT02601313<\/a><\/li>\n\n\n\n<li>ZUMA-3 (B-ALL \u03b5\u03bd\u03b7\u03bb\u03af\u03ba\u03c9\u03bd, \u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 OS 18,2 \u03bc\u03ae\u03bd\u03b5\u03c2): <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT02614066\" target=\"_blank\" rel=\"noopener\">NCT02614066<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a3\u03b5\u03bb\u03af\u03b4\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03bf\u03c2 FDA:<\/strong> <a href=\"https:\/\/www.fda.gov\/vaccines-blood-biologics\/tecartus\" target=\"_blank\" rel=\"noopener\">FDA Tecartus<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Lisocabtagene_Maraleucel_Breyanzi%C2%AE_%E2%80%93_Bristol_Myers_Squibb\"><\/span>Lisocabtagene Maraleucel (Breyanzi\u00ae) - <em>Bristol Myers Squibb<\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0391\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf-\u03c3\u03c4\u03cc\u03c7\u03bf\u03c2:<\/strong> CD19<br><strong>\u0395\u03be\u03bf\u03c5\u03c3\u03b9\u03bf\u03b4\u03bf\u03c4\u03ae\u03b8\u03b7\u03ba\u03b5:<\/strong> FDA \u03a6\u03b5\u03b2\u03c1\u03bf\u03c5\u03ac\u03c1\u03b9\u03bf\u03c2 2021 (\u03b1\u03c1\u03c7\u03b9\u03ba\u03ae) \/ \u03b5\u03ba\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 2022-2024 \/ EMA \u039f\u03ba\u03c4\u03ce\u03b2\u03c1\u03b9\u03bf\u03c2 2022<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0395\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u039b\u03ad\u03bc\u03c6\u03c9\u03bc\u03b1 \u03bc\u03b5\u03b3\u03ac\u03bb\u03c9\u03bd \u0392-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (LBCL, DLBCL, HGBCL, FL) 2\u03b7\u03c2 + 3\u03b7\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae\u03c2<\/li>\n\n\n\n<li>\u03a7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03bb\u03b5\u03c5\u03c7\u03b1\u03b9\u03bc\u03af\u03b1 (\u03a7\u039b\u039b)\/\u03bc\u03b9\u03ba\u03c1\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc \u03bb\u03b5\u03bc\u03c6\u03ce\u03b4\u03b5\u03c2 \u03bb\u03ad\u03bc\u03c6\u03c9\u03bc\u03b1 (SLL) \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u22652 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1 BTK (FDA 2024)<\/li>\n\n\n\n<li>\u039f\u03b6\u03ce\u03b4\u03b5\u03c2 \u03bb\u03ad\u03bc\u03c6\u03c9\u03bc\u03b1 (FL) \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u22652 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>TRANSFORM (DLBCL 2\u03b7\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae\u03c2): <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03575351\" target=\"_blank\" rel=\"noopener\">NCT03575351<\/a><\/li>\n\n\n\n<li>TRANSCEND-CLL-004 (CLL\/SLL): <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03331198\" target=\"_blank\" rel=\"noopener\">NCT03331198<\/a> | <a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(24)00422-7\/fulltext\" target=\"_blank\" rel=\"noopener\">Lancet 2024<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a3\u03b5\u03bb\u03af\u03b4\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03bf\u03c2 FDA:<\/strong> <a href=\"https:\/\/www.fda.gov\/vaccines-blood-biologics\/breyanzi\" target=\"_blank\" rel=\"noopener\">FDA Breyanzi<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Idecabtagene_Vicleucel_Abecma%C2%AE_%E2%80%93_Bristol_Myers_Squibb_2seventy_bio\"><\/span>Idecabtagene Vicleucel (Abecma\u00ae) - <em>Bristol Myers Squibb \/ 2seventy bio<\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0391\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf-\u03c3\u03c4\u03cc\u03c7\u03bf\u03c2:<\/strong> BCMA (\u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf \u03c9\u03c1\u03af\u03bc\u03b1\u03bd\u03c3\u03b7\u03c2 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u0392)<br><strong>\u0395\u03be\u03bf\u03c5\u03c3\u03b9\u03bf\u03b4\u03bf\u03c4\u03ae\u03b8\u03b7\u03ba\u03b5:<\/strong> FDA \u039c\u03ac\u03c1\u03c4\u03b9\u03bf\u03c2 2021 \/ EMA \u0391\u03cd\u03b3\u03bf\u03c5\u03c3\u03c4\u03bf\u03c2 2021<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0388\u03bd\u03b4\u03b5\u03b9\u03be\u03b7<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u03a5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03bf\u03bd\/\u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03cc \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u22654 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03b5\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ad\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0397 \u03c0\u03b9\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u039c\u03b5\u03bb\u03ad\u03c4\u03b7 KarMMa (ORR 73 %): <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03361748\" target=\"_blank\" rel=\"noopener\">NCT03361748<\/a> | <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2024850\" target=\"_blank\" rel=\"noopener\">NEJM 2021<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a3\u03b5\u03bb\u03af\u03b4\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03bf\u03c2 FDA:<\/strong> <a href=\"https:\/\/www.fda.gov\/vaccines-blood-biologics\/abecma\" target=\"_blank\" rel=\"noopener\">FDA Abecma<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Ciltacabtagene_Autoleucel_Carvykti%C2%AE_%E2%80%93_JanssenLegend_Biotech\"><\/span>Ciltacabtagene Autoleucel (Carvykti\u00ae) - <em>Janssen\/Legend Biotech<\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0391\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf-\u03c3\u03c4\u03cc\u03c7\u03bf\u03c2:<\/strong> BCMA (\u03b4\u03b9\u03c0\u03bb\u03ae\u03c2 \u03b4\u03ad\u03c3\u03bc\u03b5\u03c5\u03c3\u03b7\u03c2)<br><strong>\u0395\u03be\u03bf\u03c5\u03c3\u03b9\u03bf\u03b4\u03bf\u03c4\u03ae\u03b8\u03b7\u03ba\u03b5:<\/strong> FDA \u03a6\u03b5\u03b2\u03c1\u03bf\u03c5\u03ac\u03c1\u03b9\u03bf\u03c2 2022 (\u22654 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ad\u03c2), \u03c0\u03b1\u03c1\u03b1\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03b7 \u0391\u03c0\u03c1\u03af\u03bb\u03b9\u03bf\u03c2 2024 (\u22651 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae) \/ EMA \u039c\u03ac\u03b9\u03bf\u03c2 2022<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0395\u03b9\u03b4\u03b9\u03ba\u03cc \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc:<\/strong> \u039c\u03bf\u03bd\u03b1\u03b4\u03b9\u03ba\u03cc CAR \u03b4\u03b9\u03c0\u03bb\u03bf\u03cd \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03bc\u03b5 \u03b4\u03cd\u03bf \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03bc\u03bf\u03bd\u03ae\u03c2 \u03b4\u03bf\u03bc\u03ae\u03c2 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03c3\u03bc\u03b5\u03cd\u03bf\u03c5\u03bd \u03c4\u03bf BCMA- \u03b8\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03b7 \u03c0\u03b9\u03bf \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03c5\u03b5\u03bb\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03bc\u03ad\u03c7\u03c1\u03b9 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0395\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u03a5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03bf\u03bd\/\u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03cc \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u22654 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ad\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2<\/li>\n\n\n\n<li>\u0391\u03c0\u03cc \u03c4\u03bf\u03bd \u0391\u03c0\u03c1\u03af\u03bb\u03b9\u03bf \u03c4\u03bf\u03c5 2024 (FDA): \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u22651 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03b3\u03b9\u03b1 \u03bd\u03cc\u03c3\u03bf \u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03c3\u03c4\u03b7 \u03bb\u03b5\u03bd\u03b1\u03bb\u03b9\u03b4\u03bf\u03bc\u03af\u03b4\u03b7<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>CARTITUDE-1 (ORR 98 %, CR 78 %): <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03548207\" target=\"_blank\" rel=\"noopener\">NCT03548207<\/a> | <a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(21)00933-4\/fulltext\" target=\"_blank\" rel=\"noopener\">Lancet 2021<\/a><\/li>\n\n\n\n<li>CARTITUDE-4 (\u03a6\u03ac\u03c3\u03b7 3, \u03c0\u03b1\u03c1\u03ac\u03c4\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 1\u03b7\u03c2 \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae\u03c2): <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04181827\" target=\"_blank\" rel=\"noopener\">NCT04181827<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a3\u03b5\u03bb\u03af\u03b4\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03bf\u03c2 FDA:<\/strong> <a href=\"https:\/\/www.fda.gov\/vaccines-blood-biologics\/carvykti\" target=\"_blank\" rel=\"noopener\">FDA Carvykti<\/a><br><strong>\u039a\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae\u03c2:<\/strong> <a href=\"https:\/\/www.carvykti.com\" target=\"_blank\" rel=\"noopener\">carvykti.com<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Obecabtagene_Autoleucel_Aucatzyl%C2%AE_%E2%80%93_Autolus_neu_112024\"><\/span>Obecabtagene Autoleucel (Aucatzyl\u00ae) - <em>Autolus<\/em> <em>(\u03bd\u03ad\u03b1: 11.2024)<\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0391\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf-\u03c3\u03c4\u03cc\u03c7\u03bf\u03c2:<\/strong> CD19 (\u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03cc\u03c2 \u03c4\u03b1\u03c7\u03b5\u03af\u03b1\u03c2 \u03b1\u03c0\u03bf\u03b4\u03ad\u03c3\u03bc\u03b5\u03c5\u03c3\u03b7\u03c2 - \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03c0\u03c1\u03bf\u03ba\u03ac\u03c4\u03bf\u03c7\u03bf)<br><strong>\u0395\u03be\u03bf\u03c5\u03c3\u03b9\u03bf\u03b4\u03bf\u03c4\u03ae\u03b8\u03b7\u03ba\u03b5:<\/strong> FDA 8 \u039d\u03bf\u03b5\u03bc\u03b2\u03c1\u03af\u03bf\u03c5 2024<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0388\u03bd\u03b4\u03b5\u03b9\u03be\u03b7<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0395\u03bd\u03ae\u03bb\u03b9\u03ba\u03b5\u03c2 \u03bc\u03b5 \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03bf\u03c5\u03c3\u03b1\/\u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae ALL \u0392-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0395\u03b9\u03b4\u03b9\u03ba\u03cc \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc:<\/strong> \u03a4\u03bf \u03c0\u03c1\u03ce\u03c4\u03bf CAR-T \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd \u03c0\u03bf\u03c5 \u03b5\u03b3\u03ba\u03c1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c0\u03c1\u03cc\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1 REMS (\u03a3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae \u0391\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u039c\u03b5\u03af\u03c9\u03c3\u03b7\u03c2 \u039a\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5), \u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7 \u03b2\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03bd\u03ad\u03b1\u03c2 \u03ad\u03bd\u03bd\u03bf\u03b9\u03b1\u03c2 \u03b4\u03ad\u03c3\u03bc\u03b5\u03c5\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 CD19.<br><a href=\"https:\/\/www.dasgelbeblatt.de\/welt\/immunzelltherapie-heilt-ueberraschend-krebs-bei-einem-jugendlichen-zr-94168662.html\" target=\"_blank\" rel=\"noreferrer noopener\">\u03a4\u03bf \u03ba\u03af\u03c4\u03c1\u03b9\u03bd\u03bf \u03c6\u03cd\u03bb\u03bb\u03bf<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0397 \u03c0\u03b9\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u039c\u03b5\u03bb\u03ad\u03c4\u03b7 FELIX (\u03c6\u03ac\u03c3\u03b7 1\/2, \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc CR 42 % \u03c3\u03b5 3 \u03bc\u03ae\u03bd\u03b5\u03c2): <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04404660\" target=\"_blank\" rel=\"noopener\">NCT04404660<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a3\u03b5\u03bb\u03af\u03b4\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03bf\u03c2 FDA:<\/strong> <a href=\"https:\/\/www.fda.gov\/vaccines-blood-biologics\/aucatzyl\" target=\"_blank\" rel=\"noopener\">FDA Aucatzyl<\/a><br><strong>\u039a\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae\u03c2:<\/strong> <a href=\"https:\/\/www.autolus.com\" target=\"_blank\" rel=\"noopener\">autolus.com<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"WELTWEIT_ZUGELASSEN_%E2%80%93_NICHT_IN_USAEU_weitere_Lander\"><\/span>\u0395\u03a0\u0399\u03a4\u03a1\u0395\u03a0\u0395\u03a4\u0391\u0399 \u03a0\u0391\u0393\u039a\u039f\u03a3\u039c\u0399\u03a9\u03a3 - \u039f\u03a7\u0399 \u03a3\u03a4\u0399\u03a3 \u0397\u03a0\u0391\/\u0395\u0395 (\u03ac\u03bb\u03bb\u03b5\u03c2 \u03c7\u03ce\u03c1\u03b5\u03c2)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"China_NMPA_%E2%80%93_vier_zusatzliche_CAR-T-Produkte\"><\/span>\u039a\u03af\u03bd\u03b1 (NMPA) - \u03c4\u03ad\u03c3\u03c3\u03b5\u03c1\u03b1 \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03b1 CAR-T<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ac \u03ad\u03bd\u03c4\u03b5\u03ba\u03b1 \u03b1\u03c5\u03c4\u03cc\u03bb\u03bf\u03b3\u03b5\u03c2 CAR-T \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ad\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03bb\u03ac\u03b2\u03b5\u03b9 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ae \u03ad\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2. \u0395\u03c0\u03c4\u03ac \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd FDA \u03ba\u03b1\u03b9 \u03c4\u03ad\u03c3\u03c3\u03b5\u03c1\u03b9\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ba\u03b9\u03bd\u03b5\u03b6\u03b9\u03ba\u03ae NMPA, \u03cc\u03bb\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03bf\u03c5\u03c3\u03b5\u03c2\/\u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03b5\u03b9\u03b5\u03c2.<br><a href=\"https:\/\/ucla.clinicaltrials.researcherprofiles.org\/trial\/NCT06743126\" target=\"_blank\" rel=\"noreferrer noopener\">Immatics US, Inc.<\/a><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u0395\u03bc\u03c0\u03bf\u03c1\u03b9\u03ba\u03ae \u03bf\u03bd\u03bf\u03bc\u03b1\u03c3\u03af\u03b1<\/th><th>\u0395\u03bd\u03b5\u03c1\u03b3\u03cc \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc<\/th><th>\u0391\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf-\u03c3\u03c4\u03cc\u03c7\u03bf\u03c2<\/th><th>\u0388\u03bd\u03b4\u03b5\u03b9\u03be\u03b7<\/th><th>\u0395\u03be\u03bf\u03c5\u03c3\u03b9\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7<\/th><\/tr><\/thead><tbody><tr><td>Carteyva<\/td><td>Relmacabtagene autoleucel<\/td><td>BCMA<\/td><td>Mult. \u039c\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1, DLBCL<\/td><td>NMPA 2021\/2023<\/td><\/tr><tr><td>Fucaso<\/td><td>Equecabtagene autoleucel<\/td><td>BCMA<\/td><td>Mult. \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1<\/td><td>NMPA 2023<\/td><\/tr><tr><td>Yuanruida<\/td><td>Satricabtagene autoleucel<\/td><td>CD19<\/td><td>\u0392-\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc \u03bb\u03ad\u03bc\u03c6\u03c9\u03bc\u03b1<\/td><td>NMPA<\/td><\/tr><tr><td>Zever-cel<\/td><td>\u2014<\/td><td>CD19\/BCMA<\/td><td>Haematolog.<\/td><td>NMPA<\/td><\/tr><tr><td>Carvykti<\/td><td>Ciltacabtagene autoleucel<\/td><td>BCMA<\/td><td>Mult. \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1<\/td><td>NMPA 2024<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Indien_CDSCO\"><\/span>\u0399\u03bd\u03b4\u03af\u03b1 (CDSCO)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>NexCAR19<\/strong> (Actalycabtagene autoleucel) \u03b5\u03b3\u03ba\u03c1\u03af\u03b8\u03b7\u03ba\u03b5 \u03c4\u03bf\u03bd \u039f\u03ba\u03c4\u03ce\u03b2\u03c1\u03b9\u03bf \u03c4\u03bf\u03c5 2023 \u03c9\u03c2 \u03b7 \u03c0\u03c1\u03ce\u03c4\u03b7 CAR-T \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c0\u03c4\u03cd\u03c7\u03b8\u03b7\u03ba\u03b5 \u03c3\u03c4\u03b7\u03bd \u0399\u03bd\u03b4\u03af\u03b1. \u0397 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b1\u03bd\u03b1\u03c0\u03c4\u03cd\u03c7\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd ImmunoACT \u03c3\u03c4\u03bf IIT Bombay \u03ba\u03b1\u03b9 \u03ba\u03bf\u03c3\u03c4\u03af\u03b6\u03b5\u03b9 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 50.000 \u03b4\u03bf\u03bb\u03ac\u03c1\u03b9\u03b1 - \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03c4\u03bf \u03ad\u03bd\u03b1 \u03b4\u03ad\u03ba\u03b1\u03c4\u03bf \u03c4\u03c9\u03bd \u03c3\u03c5\u03b3\u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03c9\u03bd \u03b4\u03c5\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03c9\u03bd. <a href=\"https:\/\/www.dasgelbeblatt.de\/welt\/immunzelltherapie-heilt-ueberraschend-krebs-bei-einem-jugendlichen-zr-94168662.html\" target=\"_blank\" rel=\"noreferrer noopener\">\u03a4\u03bf \u03ba\u03af\u03c4\u03c1\u03b9\u03bd\u03bf \u03c6\u03cd\u03bb\u03bb\u03bf<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0388\u03bd\u03b4\u03b5\u03b9\u03be\u03b7<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u03a5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03bf\u03bd\/\u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc \u03bc\u03b7-Hodgkin \u03bb\u03ad\u03bc\u03c6\u03c9\u03bc\u03b1 \u03b1\u03c0\u03cc \u0392-\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ba\u03b1\u03b9 ALL \u03b1\u03c0\u03cc \u0392-\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039a\u03ad\u03bd\u03c4\u03c1\u03bf \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2:<\/strong> \u039d\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03bf Tata Memorial, \u0392\u03bf\u03bc\u03b2\u03ac\u03b7 <br><strong>\u039a\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae\u03c2:<\/strong> <a href=\"https:\/\/www.immunoact.com\" target=\"_blank\" rel=\"noopener\">ImmunoACT<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"TCR-T-ZELLTHERAPIEN_zugelassen\"><\/span>\u0398\u0395\u03a1\u0391\u03a0\u0395\u0399\u0395\u03a3 \u03bc\u03b5 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 TCR-T (\u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b5\u03c2)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Afamitresgene_Autoleucel_Tecelra%C2%AE_%E2%80%93_Adaptimmune_August_2024\"><\/span>Afamitresgene Autoleucel (Tecelra\u00ae) - <em>Adaptimmune<\/em> <em>(\u0391\u03cd\u03b3\u03bf\u03c5\u03c3\u03c4\u03bf\u03c2 2024)<\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03c4\u03b9\u03c2 2 \u0391\u03c5\u03b3\u03bf\u03cd\u03c3\u03c4\u03bf\u03c5 2024, \u03bf FDA \u03b5\u03bd\u03ad\u03ba\u03c1\u03b9\u03bd\u03b5 \u03c4\u03bf Afamitresgene autoleucel (Afami-cel, Tecelra) \u03c9\u03c2 \u03c4\u03b7\u03bd \u03c0\u03c1\u03ce\u03c4\u03b7 TCR T-cell \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 \u03c9\u03c2 \u03c4\u03bf \u03c0\u03c1\u03ce\u03c4\u03bf \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ac \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd T-cell \u03b3\u03b9\u03b1 \u03c3\u03c5\u03bc\u03c0\u03b1\u03b3\u03ae \u03cc\u03b3\u03ba\u03bf. <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12283372\/\" target=\"_blank\" rel=\"noreferrer noopener\">PubMed Central<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0391\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf-\u03c3\u03c4\u03cc\u03c7\u03bf\u03c2:<\/strong> MAGE-A4 (\u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03b9\u03bf \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03bf\u03cd \u03cc\u03c1\u03c7\u03b5\u03c9\u03c2), \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf HLA-A*02:01<br><strong>\u0395\u03be\u03bf\u03c5\u03c3\u03b9\u03bf\u03b4\u03bf\u03c4\u03ae\u03b8\u03b7\u03ba\u03b5:<\/strong> FDA \u0391\u03cd\u03b3\u03bf\u03c5\u03c3\u03c4\u03bf\u03c2 2024<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0388\u03bd\u03b4\u03b5\u03b9\u03be\u03b7<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0395\u03bd\u03ae\u03bb\u03b9\u03ba\u03b5\u03c2 \u03bc\u03b5 \u03b1\u03bd\u03b5\u03b3\u03c7\u03b5\u03af\u03c1\u03b7\u03c4\u03bf \u03ae \u03bc\u03b5\u03c4\u03b1\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf <strong>\u03a3\u03c5\u03bd\u03b4\u03b5\u03c3\u03bc\u03b9\u03ba\u03cc \u03c3\u03ac\u03c1\u03ba\u03c9\u03bc\u03b1<\/strong> (\u03c3\u03ac\u03c1\u03ba\u03c9\u03bc\u03b1 \u03bc\u03b1\u03bb\u03b1\u03ba\u03ce\u03bd \u03bc\u03bf\u03c1\u03af\u03c9\u03bd), \u03c0\u03c1\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03bc\u03b5 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03c3\u03b5 MAGE-A4 \u03ba\u03b1\u03b9 HLA-A*02:01<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03c4\u03b7 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ae \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03c6\u03ac\u03c3\u03b7\u03c2 2 SPEARHEAD-1, \u03bf\u03b9 \u03cc\u03b3\u03ba\u03bf\u03b9 \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u03b1\u03c1\u03b8\u03c1\u03b9\u03ba\u03cc \u03c3\u03ac\u03c1\u03ba\u03c9\u03bc\u03b1 \u03b1\u03bd\u03c4\u03b1\u03c0\u03bf\u03ba\u03c1\u03af\u03b8\u03b7\u03ba\u03b1\u03bd \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 \u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 11,6 \u03bc\u03b7\u03bd\u03ce\u03bd. \u03a3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2, \u03b4\u03b5\u03bd \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03bd\u03b1 \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03c5\u03b8\u03b5\u03af \u03cc\u03b3\u03ba\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03b1\u03c1\u03ba\u03b5\u03c4\u03ac \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1. <a href=\"https:\/\/www.clinicaltrialvanguard.com\/news\/t-knife-files-for-phase-1-trial-of-prame-t-cell-therapy\/\" target=\"_blank\" rel=\"noreferrer noopener\">Clinicaltrialvanguard<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0397 \u03c0\u03b9\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>SPEARHEAD-1 (\u03a6\u03ac\u03c3\u03b7 2): <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04044858\" target=\"_blank\" rel=\"noopener\">NCT04044858<\/a> | <a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(24)00319-2\/fulltext\" target=\"_blank\" rel=\"noopener\">Lancet \u0391\u03c0\u03c1\u03af\u03bb\u03b9\u03bf\u03c2 2024<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039a\u03ad\u03bd\u03c4\u03c1\u03bf \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 (Pioneer):<\/strong> \u039a\u03ad\u03bd\u03c4\u03c1\u03bf \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 Memorial Sloan Kettering, \u039d\u03ad\u03b1 \u03a5\u03cc\u03c1\u03ba\u03b7 - <a href=\"https:\/\/www.mskcc.org\/news\/immunotherapy-clinical-trial-shows-promise-for-treating-rare-sarcomas\" target=\"_blank\" rel=\"noopener\">\u03a0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf MSK Tecelra<\/a><br><strong>\u03a3\u03b5\u03bb\u03af\u03b4\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03bf\u03c2 FDA:<\/strong> <a href=\"https:\/\/www.fda.gov\/vaccines-blood-biologics\/tecelra\" target=\"_blank\" rel=\"noopener\">FDA Tecelra<\/a> <br><strong>\u0386\u03c1\u03b8\u03c1\u03bf \u03c4\u03bf\u03c5 NCI:<\/strong> <a href=\"https:\/\/www.cancer.gov\/news-events\/cancer-currents-blog\/2024\/fda-tecelra-synovial-sarcoma-mage-a4\" target=\"_blank\" rel=\"noopener\">cancer.gov \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 TCR<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Tebentafusp-tebn_Kimmtrak%C2%AE_%E2%80%93_Immunocore_Januar_2022\"><\/span>Tebentafusp-tebn (Kimmtrak\u00ae) - <em>Immunocore<\/em> <em>(\u0399\u03b1\u03bd\u03bf\u03c5\u03ac\u03c1\u03b9\u03bf\u03c2 2022)<\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u0394\u03b5\u03bd \u03c0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03ad\u03bd\u03b1 \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03cc \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd (\u03cc\u03c7\u03b9 \u03ad\u03bd\u03b1 \u03b5\u03b3\u03c7\u03c5\u03cc\u03bc\u03b5\u03bd\u03bf \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd \u03a4-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd), \u03b1\u03bb\u03bb\u03ac \u03b3\u03b9\u03b1 \u03bc\u03b9\u03b1 \u03b4\u03b9\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03c3\u03cd\u03bd\u03c4\u03b7\u03be\u03b7\u03c2 TCR, \u03b1\u03bb\u03bb\u03ac \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03ba\u03ac \u03b1\u03bd\u03ae\u03ba\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03bf\u03bd TCR \u03ba\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03c3\u03c5\u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03c9\u03c2 \u03c0\u03c1\u03cc\u03b4\u03c1\u03bf\u03bc\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03c4\u03b5\u03c7\u03bd\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 PRAME-TCER\u00ae.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2:<\/strong> \u03a3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03bc\u03af\u03b1 \u03c0\u03bb\u03b5\u03c5\u03c1\u03ac \u03bc\u03b5 \u03c4\u03bf \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf gp100+HLA-A*02:01 \u03c3\u03c4\u03b1 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ac\u03bb\u03bb\u03b7 \u03bc\u03b5 \u03c4\u03bf CD3 \u03c3\u03c4\u03b1 \u03a4 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 (\u03c4\u03b5\u03c7\u03bd\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 ImmTAC).<br><strong>\u0395\u03be\u03bf\u03c5\u03c3\u03b9\u03bf\u03b4\u03bf\u03c4\u03ae\u03b8\u03b7\u03ba\u03b5:<\/strong> FDA \u0399\u03b1\u03bd\u03bf\u03c5\u03ac\u03c1\u03b9\u03bf\u03c2 2022 \/ EMA \u03a6\u03b5\u03b2\u03c1\u03bf\u03c5\u03ac\u03c1\u03b9\u03bf\u03c2 2022<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0388\u03bd\u03b4\u03b5\u03b9\u03be\u03b7:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>HLA-A*02:01-\u03b8\u03b5\u03c4\u03b9\u03ba\u03bf\u03af \u03b5\u03bd\u03ae\u03bb\u03b9\u03ba\u03b5\u03c2 \u03bc\u03b5 \u03b1\u03bd\u03b5\u03b3\u03c7\u03b5\u03af\u03c1\u03b7\u03c4\u03bf \u03ae \u03bc\u03b5\u03c4\u03b1\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf <strong>\u03bc\u03b5\u03bb\u03ac\u03bd\u03c9\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03c1\u03b1\u03b3\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2<\/strong> (\u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03cc \u03bc\u03b5\u03bb\u03ac\u03bd\u03c9\u03bc\u03b1) - 1\u03b7 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0395\u03b9\u03b4\u03b9\u03ba\u03cc \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc:<\/strong> \u03a4\u03bf \u03c0\u03c1\u03ce\u03c4\u03bf \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03c0\u03bf\u03c5 \u03b5\u03b3\u03ba\u03c1\u03af\u03b8\u03b7\u03ba\u03b5 \u03c0\u03bf\u03c4\u03ad \u03b3\u03b9\u03b1 \u03c4\u03bf \u03bc\u03b5\u03bb\u03ac\u03bd\u03c9\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03c1\u03b1\u03b3\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2 \u03c7\u03b9\u03c4\u03ce\u03bd\u03b1<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c6\u03ac\u03c3\u03b7\u03c2 3 IMCgp100-202, \u03c4\u03bf tebentafusp \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03c0\u03bb\u03b5\u03bf\u03bd\u03ad\u03ba\u03c4\u03b7\u03bc\u03b1 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae\u03c2 \u03c4\u03bf\u03c5 \u03b9\u03b1\u03c4\u03c1\u03bf\u03cd (\u03c0\u03b5\u03bc\u03c0\u03c1\u03bf\u03bb\u03b9\u03b6\u03bf\u03c5\u03bc\u03ac\u03bc\u03c0\u03b7, \u03b9\u03c0\u03b9\u03bb\u03b9\u03bc\u03bf\u03c5\u03bc\u03ac\u03bc\u03c0\u03b7 \u03ae \u03b4\u03b1\u03ba\u03b1\u03c1\u03b2\u03b1\u03b6\u03af\u03bd\u03b7): \u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 OS 21,7 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 16,0 \u03bc\u03b7\u03bd\u03ce\u03bd (HR 0,51; p&lt;0,0001). \u03a4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc OS 1 \u03ad\u03c4\u03bf\u03c5\u03c2 \u03ae\u03c4\u03b1\u03bd 73 % \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 59 %. <a href=\"https:\/\/www.kitz-heidelberg.de\/das-kitz\/kitz-programme\/\" target=\"_blank\" rel=\"noreferrer noopener\">Kitz-heidelberg<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0397 \u03c0\u03b9\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>IMCgp100-202 (\u03a6\u03ac\u03c3\u03b7 3): <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03070392\" target=\"_blank\" rel=\"noopener\">NCT03070392<\/a> | <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2103485\" target=\"_blank\" rel=\"noopener\">NEJM 2021<\/a> | <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2304753\" target=\"_blank\" rel=\"noopener\">3\u03b5\u03c4\u03ae\u03c2 \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7 NEJM 2023<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a3\u03b5\u03bb\u03af\u03b4\u03b1 FDA:<\/strong> <a href=\"https:\/\/www.fda.gov\/drugs\/resources-information-approved-drugs\/fda-disco-burst-edition-fda-approves-tebentafusp-tebn-unresectable-or-metastatic-uveal-melanoma\" target=\"_blank\" rel=\"noopener\">fda.gov Kimmtrak<\/a> <br><strong>\u039a\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae\u03c2:<\/strong> <a href=\"https:\/\/www.immunocore.com\/pipeline\/kimmtrak\" target=\"_blank\" rel=\"noopener\">immunocore.com\/kimmtrak<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"TIL-THERAPIE_zugelassen\"><\/span>TIL-\u0398\u0395\u03a1\u0391\u03a0\u0395\u0399\u0391 (\u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Lifileucel_Amtagvi%C2%AE_%E2%80%93_Iovance_Biotherapeutics_Februar_2024\"><\/span>Lifileucel (Amtagvi\u00ae) - <em>Iovance Biotherapeutics<\/em> <em>(\u03a6\u03b5\u03b2\u03c1\u03bf\u03c5\u03ac\u03c1\u03b9\u03bf\u03c2 2024)<\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf Lifileucel \u03b5\u03b3\u03ba\u03c1\u03af\u03b8\u03b7\u03ba\u03b5 \u03c3\u03c4\u03b9\u03c2 16 \u03a6\u03b5\u03b2\u03c1\u03bf\u03c5\u03b1\u03c1\u03af\u03bf\u03c5 2024 \u03c9\u03c2 \u03b7 \u03c0\u03c1\u03ce\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03a4-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03b3\u03b9\u03b1 \u03c3\u03c5\u03bc\u03c0\u03b1\u03b3\u03ae \u03cc\u03b3\u03ba\u03bf \u03ba\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b7 \u03c0\u03c1\u03ce\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 TIL \u03c3\u03c4\u03b7\u03bd \u03b9\u03c3\u03c4\u03bf\u03c1\u03af\u03b1. <a href=\"https:\/\/investors.immatics.com\/news-releases\/news-release-details\/immatics-initiates-phase-12-clinical-trial-evaluate-prame-tcr\/\" target=\"_blank\" rel=\"noreferrer noopener\">Immatics N.V.<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2:<\/strong> \u039f \u03cc\u03b3\u03ba\u03bf\u03c2 \u03b1\u03c6\u03b1\u03b9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c7\u03b5\u03b9\u03c1\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ac, \u03b1\u03c0\u03bf\u03bc\u03bf\u03bd\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03cc\u03b3\u03ba\u03bf (TIL), \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b1\u03b6\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b1\u03bd\u03b1\u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03bb\u03b5\u03bc\u03c6\u03bf\u03b1\u03c0\u03bf\u03bc\u03ac\u03ba\u03c1\u03c5\u03bd\u03c3\u03b7. \u0394\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 - \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b7 \u03c6\u03c5\u03c3\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03b3\u03bd\u03ce\u03c1\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5 \u03b1\u03c0\u03cc \u03c4\u03b1 TIL.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0388\u03bd\u03b4\u03b5\u03b9\u03be\u03b7<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0395\u03bd\u03ae\u03bb\u03b9\u03ba\u03b5\u03c2 \u03bc\u03b5 \u03b1\u03bd\u03b5\u03b3\u03c7\u03b5\u03af\u03c1\u03b7\u03c4\u03bf \u03ae \u03bc\u03b5\u03c4\u03b1\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf <strong>\u039c\u03b5\u03bb\u03ac\u03bd\u03c9\u03bc\u03b1<\/strong> (\u03b4\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03bc\u03b5\u03bb\u03ac\u03bd\u03c9\u03bc\u03b1) \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 anti-PD-1 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1 BRAF\/MEK (\u03b5\u03ac\u03bd \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b1\u03c7\u03b8\u03b5\u03af \u03bf BRAF)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03c4\u03b7\u03bd 5\u03b5\u03c4\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2 \u03a6\u03ac\u03c3\u03b7\u03c2 2 C-144-01, \u03c4\u03bf Lifileucel \u03ba\u03b1\u03c4\u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b5\u03b9\u03bc\u03b5\u03bd\u03b9\u03ba\u03cc \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 31,4 % \u03ba\u03b1\u03b9 \u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 36,5 \u03bc\u03ae\u03bd\u03b5\u03c2 - \u03bc\u03b5 \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03ae\u03c3\u03b9\u03bc\u03b7 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf\u03c5\u03c2 \u03b1\u03c0\u03cc 30 \u03b1\u03bd\u03c4\u03b1\u03c0\u03bf\u03ba\u03c1\u03b9\u03bd\u03cc\u03bc\u03b5\u03bd\u03bf\u03c5\u03c2 %. <a href=\"https:\/\/dailyreporter.esmo.org\/esmo-immuno-oncology-congress-2025\/news\/next-generation-prame-directed-tcr-t-cell-therapy-shows-early-activity-in-solid-tumours\" target=\"_blank\" rel=\"noreferrer noopener\">Esmo<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0397 \u03c0\u03b9\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>C-144-01 (\u03a6\u03ac\u03c3\u03b7 2, NCT02360579): <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT02360579\" target=\"_blank\" rel=\"noopener\">ClinicalTrials<\/a> | <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40699950\/\" target=\"_blank\" rel=\"noopener\">\u03a0\u03b5\u03c1\u03af\u03bb\u03b7\u03c8\u03b7 \u03ad\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 FDA PubMed<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039a\u03ad\u03bd\u03c4\u03c1\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 (\u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae \u0397\u03a0\u0391):<\/strong> Johns Hopkins, UCLA, MD Anderson, UCSF, Memorial Sloan Kettering, Mayo Clinic<br><strong>\u0386\u03c1\u03b8\u03c1\u03bf \u03c4\u03bf\u03c5 NCI:<\/strong> <a href=\"https:\/\/www.cancer.gov\/news-events\/cancer-currents-blog\/2024\/fda-amtagvi-til-therapy-melanoma\" target=\"_blank\" rel=\"noopener\">cancer.gov \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 TIL<\/a><br><strong>\u039a\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae\u03c2:<\/strong> <a href=\"https:\/\/www.iovance.com\" target=\"_blank\" rel=\"noopener\">iovance.com<\/a><br><strong>\u03a3\u03b5\u03bb\u03af\u03b4\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03bf\u03c2 FDA:<\/strong> <a href=\"https:\/\/www.fda.gov\/vaccines-blood-biologics\/amtagvi\" target=\"_blank\" rel=\"noopener\">FDA Amtagvi<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Ubersicht_aller_Immunzelltherapien_weltweit\"><\/span>\u0395\u03c0\u03b9\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 \u03cc\u03bb\u03c9\u03bd \u03c4\u03c9\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ce\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03b9\u03ce\u03bd \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u03a0\u03c1\u03bf\u03ca\u03cc\u03bd<\/th><th>\u0395\u03bd\u03b5\u03c1\u03b3\u03cc \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc<\/th><th>\u03a4\u03cd\u03c0\u03bf\u03c2<\/th><th>\u03a3\u03c4\u03cc\u03c7\u03bf\u03c2<\/th><th>\u0388\u03bd\u03b4\u03b5\u03b9\u03be\u03b7<\/th><th>\u0395\u03be\u03bf\u03c5\u03c3\u03b9\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7<\/th><th>\u0388\u03c4\u03bf\u03c2<\/th><\/tr><\/thead><tbody><tr><td><strong>Kymriah<\/strong><\/td><td>Tisagenlecleucel<\/td><td>CAR-T<\/td><td>CD19<\/td><td>B-ALL \u03c0\u03b1\u03b9\u03b4\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae, LBCL, FL<\/td><td>FDA, EMA<\/td><td>2017<\/td><\/tr><tr><td><strong>Yescarta<\/strong><\/td><td>Axicabtagene-cel<\/td><td>CAR-T<\/td><td>CD19<\/td><td>DLBCL, PMBCL, FL, tFL<\/td><td>FDA, EMA<\/td><td>2017<\/td><\/tr><tr><td><strong>Tecartus<\/strong><\/td><td>Brexucabtagene-cel<\/td><td>CAR-T<\/td><td>CD19<\/td><td>MCL, \u03b5\u03bd\u03b7\u03bb\u03af\u03ba\u03c9\u03bd B-ALL<\/td><td>FDA, EMA<\/td><td>2020<\/td><\/tr><tr><td><strong>Breyanzi<\/strong><\/td><td>Lisocabtagene-cel<\/td><td>CAR-T<\/td><td>CD19<\/td><td>LBCL, CLL\/SLL, FL<\/td><td>FDA, EMA<\/td><td>2021<\/td><\/tr><tr><td><strong>Abecma<\/strong><\/td><td>Idecabtagene-cel<\/td><td>CAR-T<\/td><td>BCMA<\/td><td>Mult. \u039c\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1 \u22654 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ad\u03c2<\/td><td>FDA, EMA<\/td><td>2021<\/td><\/tr><tr><td><strong>Carvykti<\/strong><\/td><td>Ciltacabtagene-cel<\/td><td>CAR-T<\/td><td>BCMA<\/td><td>Mult. \u039c\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1 \u22651 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae<\/td><td>FDA, EMA, NMPA<\/td><td>2022<\/td><\/tr><tr><td><strong>Kimmtrak<\/strong><\/td><td>Tebentafusp-tebn<\/td><td>TCR-Bispecific<\/td><td>gp100+HLA<\/td><td>\u039c\u03b5\u03bb\u03ac\u03bd\u03c9\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03c9\u03c7\u03c1\u03bf\u03cd \u03c6\u03b1\u03ba\u03bf\u03cd<\/td><td>FDA, EMA<\/td><td>2022<\/td><\/tr><tr><td><strong>NexCAR19<\/strong><\/td><td>Actalycabtagene-cel<\/td><td>CAR-T<\/td><td>CD19<\/td><td>B-ALL, NHL<\/td><td>CDSCO (\u0399\u03bd\u03b4\u03af\u03b1)<\/td><td>2023<\/td><\/tr><tr><td><strong>Amtagvi<\/strong><\/td><td>Lifileucel<\/td><td>TIL<\/td><td>\u03a0\u03bf\u03bb\u03c5\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03cc<\/td><td>\u039c\u03b5\u03bb\u03ac\u03bd\u03c9\u03bc\u03b1 (\u03c3\u03c5\u03bc\u03c0\u03b1\u03b3\u03ae\u03c2 \u03cc\u03b3\u03ba\u03bf\u03c2)<\/td><td>FDA<\/td><td>2024<\/td><\/tr><tr><td><strong>Tecelra<\/strong><\/td><td>Afamitresgene-cel<\/td><td>TCR-T<\/td><td>MAGE-A4+HLA<\/td><td>\u03a3\u03c5\u03bd\u03b4\u03b5\u03c3\u03bc\u03b9\u03ba\u03cc \u03c3\u03ac\u03c1\u03ba\u03c9\u03bc\u03b1<\/td><td>FDA<\/td><td>2024<\/td><\/tr><tr><td><strong>Aucatzyl<\/strong><\/td><td>Obecabtagene-cel<\/td><td>CAR-T<\/td><td>CD19<\/td><td>\u0395\u03bd\u03b7\u03bb\u03af\u03ba\u03c9\u03bd B-ALL<\/td><td>FDA<\/td><td>2024<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Nebenwirkungen_%E2%80%93_Was_alle_Therapien_verbindet\"><\/span>\u03a0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 - \u03c4\u03b9 \u03ba\u03bf\u03b9\u03bd\u03cc \u03ad\u03c7\u03bf\u03c5\u03bd \u03cc\u03bb\u03b5\u03c2 \u03bf\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03bf\u03b9 \u03ba\u03bf\u03b9\u03bd\u03bf\u03af \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03b9:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039a\u03b1\u03c4\u03b1\u03b9\u03b3\u03af\u03b4\u03b1 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd (CRS)<\/strong><br>\u0395\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03bc\u03b5 CAR-T \u03ba\u03b1\u03b9 TCR-T- \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03bc\u03b5 TIL.<br>\u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 tocilizumab.<br>\u0391\u03c0\u03cc \u03c4\u03bf 2024 \u03c3\u03b5 \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03b5\u03c4\u03b9\u03ba\u03ad\u03c4\u03b5\u03c2 CAR-T: \u03c0\u03c1\u03bf\u03b5\u03b9\u03b4\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c3\u03b5 \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf \u03b3\u03b9\u03b1 \u03b4\u03b5\u03c5\u03c4\u03b5\u03c1\u03bf\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03b5\u03b9\u03b5\u03c2 \u03a4-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (\u03c0\u03bf\u03bb\u03cd \u03c3\u03c0\u03ac\u03bd\u03b9\u03b5\u03c2, ~3,6 % \u03b5\u03bd\u03c4\u03cc\u03c2 \u03b5\u03c4\u03ce\u03bd).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>ICANS (\u03bd\u03b5\u03c5\u03c1\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1)<\/strong><br>\u03a3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03bd\u03b5\u03c5\u03c1\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c3\u03c7\u03b5\u03c4\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03bf \u03bc\u03b5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1- \u03b3\u03bd\u03c9\u03c3\u03c4\u03cc \u03c3\u03b5 CAR-T, \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c3\u03c5\u03c7\u03bd\u03cc \u03c3\u03b5 TIL.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039a\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03c0\u03b5\u03bd\u03af\u03b5\u03c2<\/strong><br>\u0397 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b7 \u03bb\u03b5\u03bc\u03c6\u03bf\u03b1\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7 (\u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ad\u03b3\u03c7\u03c5\u03c3\u03b7) \u03ad\u03c7\u03b5\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b2\u03c1\u03b1\u03c7\u03c5\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c3\u03c4\u03bf\u03bd \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc \u03c4\u03c9\u03bd \u03b1\u03b9\u03bc\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03c9\u03bd.<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wo_werden_diese_Therapien_in_Deutschland_angeboten\"><\/span>\u03a0\u03bf\u03cd \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03bf\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03c3\u03c4\u03b7 \u0393\u03b5\u03c1\u03bc\u03b1\u03bd\u03af\u03b1;<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u038c\u03bb\u03b1 \u03c4\u03b1 \u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd FDA\/EMA \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03b1 CAR-T \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 <strong>\u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b1 \u03ba\u03ad\u03bd\u03c4\u03c1\u03b1 \u03bc\u03b5\u03c4\u03b1\u03bc\u03bf\u03c3\u03c7\u03b5\u03cd\u03c3\u03b5\u03c9\u03bd<\/strong> \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03b5\u03c5\u03bc\u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd DKMS\/EBMT:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03b9\u03b1\u03ba\u03cc \u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03cc \u039a\u03ad\u03bd\u03c4\u03c1\u03bf Hamburg-Eppendorf (UKE):<\/strong> <a href=\"https:\/\/www.uke.de\" target=\"_blank\" rel=\"noopener\">uke.de<\/a><\/li>\n\n\n\n<li><strong>Charit\u00e9 - Universit\u00e4tsmedizin Berlin:<\/strong> <a href=\"https:\/\/www.charite.de\" target=\"_blank\" rel=\"noopener\">charite.de<\/a><\/li>\n\n\n\n<li><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u039a\u03ad\u03bd\u03c4\u03c1\u03bf LMU \u03c4\u03bf\u03c5 \u039c\u03bf\u03bd\u03ac\u03c7\u03bf\u03c5:<\/strong> <a href=\"https:\/\/www.lmu-klinikum.de\" target=\"_blank\" rel=\"noopener\">lmu-klinikum.de<\/a><\/li>\n\n\n\n<li><strong>\u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03b9\u03b1\u03ba\u03cc \u039d\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03bf \u03c4\u03b7\u03c2 \u03a7\u03b1\u03ca\u03b4\u03b5\u03bb\u03b2\u03ad\u03c1\u03b3\u03b7\u03c2 \/ KiTZ:<\/strong> <a href=\"https:\/\/www.kitz-heidelberg.de\" target=\"_blank\" rel=\"noopener\">kitz-heidelberg.de<\/a> <em>(\u03b5\u03c0\u03af\u03c3\u03b7\u03c2: \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 PRAME)<\/em><\/li>\n\n\n\n<li><strong>\u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03b9\u03b1\u03ba\u03cc \u039d\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03bf \u03a6\u03c1\u03b1\u03bd\u03ba\u03c6\u03bf\u03cd\u03c1\u03c4\u03b7\u03c2:<\/strong> <a href=\"https:\/\/www.uniklinik-frankfurt.de\" target=\"_blank\" rel=\"noopener\">uniklinik-frankfurt.de<\/a><\/li>\n\n\n\n<li><strong>\u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03b9\u03b1\u03ba\u03cc \u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03cc \u039a\u03ad\u03bd\u03c4\u03c1\u03bf \u03a6\u03c1\u03ac\u03b9\u03bc\u03c0\u03bf\u03c5\u03c1\u03b3\u03ba:<\/strong> <a href=\"https:\/\/www.uniklinik-freiburg.de\" target=\"_blank\" rel=\"noopener\">uniklinik-freiburg.de<\/a><\/li>\n\n\n\n<li><strong>\u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03b9\u03b1\u03ba\u03cc \u039d\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03bf \u039d\u03c4\u03af\u03c3\u03b5\u03bb\u03bd\u03c4\u03bf\u03c1\u03c6 \/ \u0388\u03c3\u03c3\u03b5\u03bd:<\/strong> \u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf MCL\/DLBCL-CAR-T<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a0\u03bb\u03ae\u03c1\u03b7\u03c2 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf\u03c2 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03c9\u03bd \u03ba\u03ad\u03bd\u03c4\u03c1\u03c9\u03bd CAR-T:<\/strong> <a href=\"https:\/\/www.ebmt.org\/registry\/center-search\" target=\"_blank\" rel=\"noopener\">\u0391\u03bd\u03b1\u03b6\u03ae\u03c4\u03b7\u03c3\u03b7 \u03ba\u03ad\u03bd\u03c4\u03c1\u03bf\u03c5 EBMT<\/a><\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Ausblick_Was_kommt_als_nachstes\"><\/span>\u03a0\u03c1\u03bf\u03bf\u03c0\u03c4\u03b9\u03ba\u03ad\u03c2: \u03a4\u03b9 \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af;<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03bf \u03ba\u03cd\u03bc\u03b1 \u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03c9\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ce\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03b9\u03ce\u03bd \u03b1\u03bd\u03b1\u03bc\u03ad\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c6\u03b8\u03ac\u03c3\u03b5\u03b9 \u03c4\u03bf 2026-2028:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>IMA203 \/ Anzu-cel (PRAME-TCR):<\/strong> \u0394\u03bf\u03ba\u03b9\u03bc\u03ae \u03c6\u03ac\u03c3\u03b7\u03c2 3 SUPRAME \u03c3\u03b5 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 - <em>\u03a0\u03b9\u03b8\u03b1\u03bd\u03ae \u03ad\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03bc\u03b5\u03bb\u03ac\u03bd\u03c9\u03bc\u03b1 2027\/2028<\/em><\/li>\n\n\n\n<li><strong>Lifileucel + \u03c0\u03b5\u03bc\u03c0\u03c1\u03bf\u03bb\u03b9\u03b6\u03bf\u03c5\u03bc\u03ac\u03bc\u03c0\u03b7 (\u03a6\u03ac\u03c3\u03b7 3):<\/strong> \u039c\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c0\u03c1\u03ce\u03c4\u03b7\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae\u03c2 NCT05727904 - <em>\u03a0\u03b9\u03b8\u03b1\u03bd\u03ae \u03ad\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c0\u03c1\u03ce\u03c4\u03b7\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03bc\u03b5\u03bb\u03ac\u03bd\u03c9\u03bc\u03b1<\/em><\/li>\n\n\n\n<li><strong>Brenetafusp (PRISM-MEL-301):<\/strong> \u039c\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c6\u03ac\u03c3\u03b7\u03c2 3 PRAME\u00d7CD3-Bispecific - <em>\u03a0\u03b9\u03b8\u03b1\u03bd\u03ae \u03ad\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 2027<\/em><\/li>\n\n\n\n<li><strong>CAR-T \u03b3\u03b9\u03b1 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b1 \u03bd\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03b1 (\u03a3\u0395\u039b, \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7 \u03ba\u03b1\u03c4\u03ac \u03c0\u03bb\u03ac\u03ba\u03b1\u03c2):<\/strong> \u0394\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03c6\u03ac\u03c3\u03b7\u03c2 2 \u03c3\u03b5 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7- \u03b5\u03bd\u03b4\u03b5\u03c7\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03c4\u03bf \u03c0\u03c1\u03ce\u03c4\u03bf \u03bc\u03b7 \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd CAR-T<\/li>\n\n\n\n<li><strong>\u03a0\u03b1\u03b9\u03b4\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 PRAME \u03c4\u03b7\u03c2 \u03a7\u03b1\u03ca\u03b4\u03b5\u03bb\u03b2\u03ad\u03c1\u03b3\u03b7\u03c2 KiTZ:<\/strong> \u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03bf 2026 - \u03b7 \u03c0\u03c1\u03ce\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b3\u03b9\u03b1 \u03c0\u03b1\u03b9\u03b4\u03b9\u03ac \u03c3\u03c4\u03bf\u03bd \u03ba\u03cc\u03c3\u03bc\u03bf<\/li>\n<\/ul>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h1 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"GKV-Erstattung_von_Immunzelltherapien_in_Deutschland\"><\/span>\u0391\u03c0\u03bf\u03b6\u03b7\u03bc\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 SHI \u03b3\u03b9\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03bc\u03b5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c3\u03c4\u03b7 \u0393\u03b5\u03c1\u03bc\u03b1\u03bd\u03af\u03b1<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">\u039a\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 02.2026<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd\u03c0\u03bb\u03bf\u03ba\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03bf\u03b9\u03ba\u03af\u03bb\u03bb\u03b5\u03b9 \u03c3\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf \u03b2\u03b1\u03b8\u03bc\u03cc \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03b5\u03af\u03b4\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2, \u03c4\u03bf \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c3\u03c6\u03b1\u03bb\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b5\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b1. \u0394\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03ba\u03b1\u03c4' \u03b1\u03c0\u03bf\u03ba\u03bf\u03c0\u03ae\u03bd, \u03b1\u03c5\u03c4\u03cc\u03bc\u03b1\u03c4\u03b7 \u03b1\u03c0\u03bf\u03b6\u03b7\u03bc\u03af\u03c9\u03c3\u03b7, \u03cc\u03c0\u03c9\u03c2 \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03bc\u03b5 \u03c4\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b4\u03bf\u03c3\u03b9\u03b1\u03ba\u03ac \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1. \u0391\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1, \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03ad\u03bd\u03b1 \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ce\u03bd \u03c3\u03c4\u03b1\u03b4\u03af\u03c9\u03bd \u03bc\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b3\u03c1\u03b1\u03c6\u03b5\u03b9\u03bf\u03ba\u03c1\u03b1\u03c4\u03af\u03b1, \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03bf\u03b9 \u03b3\u03b9\u03b1\u03c4\u03c1\u03bf\u03af \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03ba\u03c1\u03af\u03bd\u03bf\u03c5\u03bd \u03b1\u03bd\u03bf\u03b9\u03c7\u03c4\u03ac \u03c9\u03c2 \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03cc.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"CAR-T-Zelltherapien\"><\/span>\u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd CAR-T<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0393\u03b5\u03bd\u03b9\u03ba\u03ac \u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03b5\u03c0\u03c4\u03ad\u03b1, \u03b1\u03bb\u03bb\u03ac \u03c0\u03b5\u03c1\u03af\u03c0\u03bb\u03bf\u03ba\u03b1<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"AMNOG_NUB-Verfahren\"><\/span>\u0394\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 AMNOG &amp; NUB<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1 CAR-T \u03b5\u03af\u03bd\u03b1\u03b9 <strong>\u03a6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 (ATMP)<\/strong> \u03ba\u03b1\u03b9 \u03c5\u03c0\u03cc\u03ba\u03b5\u03b9\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03b3\u03b5\u03c1\u03bc\u03b1\u03bd\u03b9\u03ba\u03cc <strong>\u0394\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 AMNOG<\/strong> (\u039d\u03cc\u03bc\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03b4\u03b9\u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03b3\u03bf\u03c1\u03ac\u03c2). \u0391\u03c5\u03c4\u03cc\u03c2 \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03b5\u03b9<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Fruhe_Nutzenbewertung_durch_den_G-BA\"><\/span>\u0388\u03b3\u03ba\u03b1\u03b9\u03c1\u03b7 \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bf\u03c6\u03ad\u03bb\u03bf\u03c5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd G-BA<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u0391\u03c0\u03cc \u03c4\u03b7\u03bd 1\u03b7 \u0399\u03b1\u03bd\u03bf\u03c5\u03b1\u03c1\u03af\u03bf\u03c5 2011, \u03b7 G-BA \u03ad\u03c7\u03b5\u03b9 \u03c4\u03bf \u03b8\u03b5\u03c3\u03bc\u03bf\u03b8\u03b5\u03c4\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03b1\u03b8\u03ae\u03ba\u03bf\u03bd \u03bd\u03b1 \u03b4\u03b9\u03b5\u03be\u03ac\u03b3\u03b5\u03b9 \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bf\u03c6\u03ad\u03bb\u03bf\u03c5\u03c2 \u03b3\u03b9\u03b1 \u03cc\u03bb\u03b1 \u03c4\u03b1 \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b1 \u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03bc\u03b5 \u03bd\u03ad\u03b5\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bf\u03c5\u03c3\u03af\u03b5\u03c2 \u03b1\u03bc\u03ad\u03c3\u03c9\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03b5\u03af\u03c3\u03bf\u03b4\u03bf \u03c3\u03c4\u03b7\u03bd \u03b1\u03b3\u03bf\u03c1\u03ac.<br>\u0395\u03be\u03b5\u03c4\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03bd \u03c4\u03bf \u03bd\u03ad\u03bf \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03ba\u03b1\u03b8\u03b9\u03b5\u03c1\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 - \u03c4\u03bf \u03bb\u03b5\u03b3\u03cc\u03bc\u03b5\u03bd\u03bf <strong>\u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03b7 \u03c3\u03c5\u03b3\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1<\/strong> - \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03b5\u03b9 \u03ad\u03bd\u03b1 \u03c0\u03bb\u03b5\u03bf\u03bd\u03ad\u03ba\u03c4\u03b7\u03bc\u03b1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039d\u03bf\u03bc\u03b9\u03ba\u03ae \u03b2\u03ac\u03c3\u03b7:<\/strong> <a href=\"https:\/\/www.gesetze-im-internet.de\/sgb_5\/__35a.html\" target=\"_blank\" rel=\"noopener\">\u00a7 \u0386\u03c1\u03b8\u03c1\u03bf 35\u03b1 SGB V - \u0391\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bf\u03c6\u03ad\u03bb\u03bf\u03c5\u03c2 \u03c4\u03c9\u03bd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd (\u03bd\u03bf\u03bc\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c4\u03cd\u03c0\u03c9\u03c3\u03b7)<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ae \u03c4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1\u03c2 G-BA:<\/strong> <a href=\"https:\/\/www.g-ba.de\/themen\/arzneimittel\/arzneimittel-richtlinie-anlagen\/nutzenbewertung-35a\/\" target=\"_blank\" rel=\"noopener\">g-ba.de - \u0395\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03c0\u03b1\u03c1\u03bf\u03c7\u03ce\u03bd AMNOG \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd \u00a7 35a SGB V<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b1\u03c5\u03c4\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03bf\u03c6\u03b5\u03bb\u03ce\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c4\u03bf \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03b5\u03ba\u03ba\u03af\u03bd\u03b7\u03c3\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03b4\u03b9\u03b1\u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b5\u03cd\u03c3\u03b5\u03b9\u03c2 \u03c4\u03b9\u03bc\u03ce\u03bd \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03b7\u03c2 GKV-Spitzenverband \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03b2\u03b9\u03bf\u03bc\u03ae\u03c7\u03b1\u03bd\u03bf\u03c5.<br>\u039f\u03b9 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ad\u03c2 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03bf\u03c5 \u03bf\u03c6\u03ad\u03bb\u03bf\u03c5\u03c2 \u03bf\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03b3\u03b5\u03c1\u03bc\u03b1\u03bd\u03b9\u03ba\u03cc \u03b4\u03b9\u03ac\u03c4\u03b1\u03b3\u03bc\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bf\u03c6\u03ad\u03bb\u03bf\u03c5\u03c2 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf \u03ba\u03b5\u03c6\u03ac\u03bb\u03b1\u03b9\u03bf 5 \u03c4\u03bf\u03c5 \u039a\u03ce\u03b4\u03b9\u03ba\u03b1 \u0394\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1\u03c2 \u03c4\u03b7\u03c2 G-BA.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f\u03b9 \u03c4\u03ad\u03c3\u03c3\u03b5\u03c1\u03b9\u03c2 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2 \u03c0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03c9\u03bd \u03c0\u03b1\u03c1\u03bf\u03c7\u03ce\u03bd \u03b5\u03af\u03bd\u03b1\u03b9:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc<\/strong> \u03a0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03b1 \u03bf\u03c6\u03ad\u03bb\u03b7<\/li>\n\n\n\n<li><strong>\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc<\/strong> \u03a0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03b1 \u03bf\u03c6\u03ad\u03bb\u03b7<\/li>\n\n\n\n<li><strong>\u039a\u03ac\u03c4\u03c9<\/strong> \u03a0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03b1 \u03bf\u03c6\u03ad\u03bb\u03b7<\/li>\n\n\n\n<li><strong>\u039a\u03b1\u03bd\u03ad\u03bd\u03b1<\/strong> \u0391\u03c0\u03bf\u03b4\u03b5\u03b4\u03b5\u03b9\u03b3\u03bc\u03ad\u03bd\u03bf \u03c0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03bf \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039f\u03b9 \u03c4\u03ad\u03c3\u03c3\u03b5\u03c1\u03b9\u03c2 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b1\u03c1\u03c7\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c4\u03cd\u03c0\u03c9\u03c3\u03b7:<\/strong> <a href=\"https:\/\/www.g-ba.de\/themen\/arzneimittel\/arzneimittel-richtlinie-anlagen\/nutzenbewertung-35a\/zusatznutzen\/\" target=\"_blank\" rel=\"noopener\">g-ba.de - \u039a\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b9\u03b8\u03ad\u03bc\u03b5\u03bd\u03b7\u03c2 \u03b1\u03be\u03af\u03b1\u03c2<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039d\u03bf\u03bc\u03b9\u03ba\u03ae \u03b2\u03ac\u03c3\u03b7 \u03c4\u03c9\u03bd \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03b9\u03ce\u03bd:<\/strong> <a href=\"https:\/\/www.gesetze-im-internet.de\/am-nutzenv\/BJNR232400010.html\" target=\"_blank\" rel=\"noopener\">AM-NutzenV \u00a7 5 \u03c0\u03b1\u03c1. 7 - \u0394\u03b9\u03ac\u03c4\u03b1\u03b3\u03bc\u03b1 \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7\u03c2 \u03c0\u03b1\u03c1\u03bf\u03c7\u03ce\u03bd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd (\u03bd\u03bf\u03bc\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c4\u03cd\u03c0\u03c9\u03c3\u03b7)<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03c0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1: \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 G-BA \u03b3\u03b9\u03b1 \u03c4\u03bf Yescarta (CAR-T):<\/strong> <a href=\"https:\/\/www.g-ba.de\/bewertungsverfahren\/nutzenbewertung\/406\/\" target=\"_blank\" rel=\"noopener\">g-ba.de - \u0394\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7\u03c2 \u03bf\u03c6\u03b5\u03bb\u03ce\u03bd Axicabtagene-Ciloleucel<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u038c\u03bb\u03b5\u03c2 \u03bf\u03b9 \u03c4\u03c1\u03ad\u03c7\u03bf\u03c5\u03c3\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03bf\u03bb\u03bf\u03ba\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b5\u03c2 \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7\u03c2 G-BA:<\/strong> <a href=\"https:\/\/www.g-ba.de\/bewertungsverfahren\/nutzenbewertung\/\" target=\"_blank\" rel=\"noopener\">g-ba.de - \u0395\u03c0\u03b9\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1\u03c2 \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7\u03c2<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Preisverhandlung_nach_%C2%A7_130b_SGB_V\"><\/span>\u0394\u03b9\u03b1\u03c0\u03c1\u03b1\u03b3\u03bc\u03ac\u03c4\u03b5\u03c5\u03c3\u03b7 \u03c4\u03b9\u03bc\u03ce\u03bd \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03bf \u00a7 130b SGB V<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u039c\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03b7\u03bd \u03b1\u03c0\u03cc\u03c6\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 G-BA \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03bf \u03c0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03bf \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03bd\u03ad\u03bf\u03c5 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5, \u03b7 GKV-Spitzenverband \u03ba\u03b1\u03b9 \u03b7 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b5\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b1 \u03b4\u03b9\u03b1\u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac \u03ba\u03b1\u03bd\u03cc\u03bd\u03b1 \u03c4\u03bf \u03bb\u03b5\u03b3\u03cc\u03bc\u03b5\u03bd\u03bf \u03c0\u03bf\u03c3\u03cc \u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae\u03c2 \u03c3\u03b5 \u03c4\u03ad\u03c3\u03c3\u03b5\u03c1\u03b9\u03c2 \u03c3\u03c5\u03bd\u03b5\u03b4\u03c1\u03b9\u03ac\u03c3\u03b5\u03b9\u03c2 \u03b4\u03b9\u03b1\u03c0\u03c1\u03b1\u03b3\u03bc\u03ac\u03c4\u03b5\u03c5\u03c3\u03b7\u03c2 \u03b5\u03bd\u03c4\u03cc\u03c2 \u03ad\u03be\u03b9 \u03bc\u03b7\u03bd\u03ce\u03bd. \u0391\u03c5\u03c4\u03cc \u03b9\u03c3\u03c7\u03cd\u03b5\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03ad\u03b2\u03b4\u03bf\u03bc\u03bf \u03bc\u03ae\u03bd\u03b1 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b1\u03b3\u03bf\u03c1\u03ac \u03c9\u03c2 \u03b7 \u03bd\u03ad\u03b1 \u03c0\u03b1\u03bd\u03b5\u03bb\u03bb\u03b1\u03b4\u03b9\u03ba\u03ae \u03c4\u03b9\u03bc\u03ae \u03b4\u03b9\u03b1\u03bd\u03bf\u03bc\u03ae\u03c2 - \u03c4\u03cc\u03c3\u03bf \u03b3\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03c6\u03b1\u03bb\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03bc\u03b5 \u03c5\u03c0\u03bf\u03c7\u03c1\u03b5\u03c9\u03c4\u03b9\u03ba\u03ae \u03b1\u03c3\u03c6\u03ac\u03bb\u03b9\u03c3\u03b7, \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03b9\u03b4\u03b9\u03ce\u03c4\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c5\u03c4\u03bf\u03c0\u03bb\u03b7\u03c1\u03c9\u03c4\u03ad\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039d\u03bf\u03bc\u03b9\u03ba\u03ae \u03b2\u03ac\u03c3\u03b7:<\/strong> <a href=\"https:\/\/www.gesetze-im-internet.de\/sgb_5\/__130b.html\" target=\"_blank\" rel=\"noopener\">\u00a7 \u00a7 130b SGB V - \u03a3\u03c5\u03bc\u03c6\u03c9\u03bd\u03af\u03b5\u03c2 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b1 \u03c0\u03bf\u03c3\u03ac \u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae\u03c2 (\u03b4\u03b9\u03b1\u03c4\u03cd\u03c0\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bd\u03cc\u03bc\u03bf\u03c5)<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ae \u03c4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1\u03c2 GKV-Spitzenverband:<\/strong> <a href=\"https:\/\/www.gkv-spitzenverband.de\/krankenversicherung\/arzneimittel\/verhandlungen_nach_amnog\/rabatt_verhandlungen_nach_amnog.jsp\" target=\"_blank\" rel=\"noopener\">gkv-spitzenverband.de - \u0394\u03b9\u03b1\u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b5\u03cd\u03c3\u03b5\u03b9\u03c2 AMNOG \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd \u00a7 130b SGB V<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0395\u03c0\u03b9\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 \u03cc\u03bb\u03c9\u03bd \u03c4\u03c9\u03bd \u03b4\u03b9\u03b1\u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b5\u03c5\u03cc\u03bc\u03b5\u03bd\u03c9\u03bd \u03c0\u03bf\u03c3\u03ce\u03bd \u03b1\u03c0\u03bf\u03b6\u03b7\u03bc\u03af\u03c9\u03c3\u03b7\u03c2 (\u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd \u03c4\u03c9\u03bd \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03c9\u03bd CAR-T):<\/strong> <a href=\"https:\/\/www.gkv-spitzenverband.de\/krankenversicherung\/arzneimittel\/verhandlungen_nach_amnog\/ebv_130b\/ebv_nach_130b.jsp\" target=\"_blank\" rel=\"noopener\">gkv-spitzenverband.de - \u03a3\u03c5\u03bc\u03c6\u03c9\u03bd\u03af\u03b5\u03c2 \u03c0\u03bf\u03c3\u03bf\u03cd \u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae\u03c2<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"NUB-Verfahren_fur_Krankenhauser\"><\/span>\u0394\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 NUB \u03b3\u03b9\u03b1 \u03bd\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03b1<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u039a\u03b1\u03b8\u03ce\u03c2 \u03bf\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 CAR-T \u03c7\u03bf\u03c1\u03b7\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bd\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03b9\u03b1\u03ba\u03ae \u03b2\u03ac\u03c3\u03b7, \u03bf\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03c5\u03c0\u03cc\u03ba\u03b5\u03b9\u03bd\u03c4\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b9\u03c2 <strong>\u0394\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 NUB<\/strong> (\u039d\u03ad\u03b5\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03ac\u03c1\u03b8\u03c1\u03bf 6 \u03c0\u03b1\u03c1\u03ac\u03b3\u03c1\u03b1\u03c6\u03bf\u03c2 2 \u03c4\u03bf\u03c5 KHEntgG).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 NUB \u03ba\u03bb\u03b5\u03af\u03bd\u03b5\u03b9 \u03c4\u03bf \u03bb\u03b5\u03b3\u03cc\u03bc\u03b5\u03bd\u03bf \u201e\u03ba\u03b5\u03bd\u03cc \u03ba\u03b1\u03b9\u03bd\u03bf\u03c4\u03bf\u03bc\u03af\u03b1\u03c2\u201c, \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03af\u03bf\u03b4\u03bf \u03c4\u03c9\u03bd \u03c4\u03c1\u03b9\u03ce\u03bd \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b5\u03c4\u03ce\u03bd \u03ad\u03c9\u03c2 \u03cc\u03c4\u03bf\u03c5 \u03bc\u03b9\u03b1 \u03bd\u03ad\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b5\u03bd\u03c3\u03c9\u03bc\u03b1\u03c4\u03c9\u03b8\u03b5\u03af \u03c0\u03bb\u03ae\u03c1\u03c9\u03c2 \u03c3\u03c4\u03bf \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03ba\u03b1\u03c4' \u03b1\u03c0\u03bf\u03ba\u03bf\u03c0\u03ae\u03bd \u03c4\u03b9\u03bc\u03ce\u03bd G-DRG.<br>\u039a\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03b1\u03c5\u03c4\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03cc\u03b4\u03bf\u03c5, \u03c4\u03b1 \u03bd\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03bd\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03b9\u03b1\u03ba\u03ad\u03c2 \u03b1\u03bc\u03bf\u03b9\u03b2\u03ad\u03c2 NUB \u03bc\u03b5 \u03c4\u03b1 \u03b1\u03c3\u03c6\u03b1\u03bb\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c4\u03b1\u03bc\u03b5\u03af\u03b1, \u03c5\u03c0\u03cc \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03cb\u03c0\u03cc\u03b8\u03b5\u03c3\u03b7 \u03cc\u03c4\u03b9 \u03c4\u03bf \u0399\u03bd\u03c3\u03c4\u03b9\u03c4\u03bf\u03cd\u03c4\u03bf \u03b3\u03b9\u03b1 \u03c4\u03bf \u03a3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u0391\u03bc\u03bf\u03b9\u03b2\u03ce\u03bd \u039d\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03c9\u03bd (InEK) \u03b1\u03c0\u03bf\u03bd\u03ad\u03bc\u03b5\u03b9 \u03c4\u03bf \u03ba\u03b1\u03b8\u03b5\u03c3\u03c4\u03ce\u03c2 1 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03b5\u03c0\u03b1\u03bd\u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03b1 \u03bd\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c5\u03c0\u03bf\u03b2\u03ac\u03bb\u03bb\u03bf\u03c5\u03bd \u03c4\u03b9\u03c2 \u03b1\u03b9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 NUB \u03c3\u03c4\u03bf InEK \u03ad\u03c9\u03c2 \u03c4\u03b9\u03c2 31 \u039f\u03ba\u03c4\u03c9\u03b2\u03c1\u03af\u03bf\u03c5 \u03ba\u03ac\u03b8\u03b5 \u03ad\u03c4\u03bf\u03c5\u03c2. \u03a4\u03bf InEK \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03cd\u03b5\u03b9 \u03c4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03ae\u03c2 \u03c4\u03bf\u03c5 \u03ad\u03c9\u03c2 \u03c4\u03bf \u03c4\u03ad\u03bb\u03bf\u03c2 \u0399\u03b1\u03bd\u03bf\u03c5\u03b1\u03c1\u03af\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03bf\u03c5 \u03ad\u03c4\u03bf\u03c5\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0393\u03b9\u03b1 \u03c4\u03b1 \u0391\u03a4\u039c\u03a1 (\u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bc\u03ad\u03bd\u03c9\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03b9\u03ce\u03bd) - \u03c3\u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03cc\u03bb\u03b1 \u03c4\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03b1 CAR-T \u03ba\u03b1\u03b9 TCR-T - \u03b9\u03c3\u03c7\u03cd\u03b5\u03b9 \u03b7 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03b7 \u03c0\u03c1\u03bf\u03b8\u03b5\u03c3\u03bc\u03af\u03b1 \u03c5\u03c0\u03bf\u03b2\u03bf\u03bb\u03ae\u03c2 \u03b1\u03b9\u03c4\u03ae\u03c3\u03b5\u03c9\u03bd \u03c3\u03c4\u03b9\u03c2 30 \u0391\u03c0\u03c1\u03b9\u03bb\u03af\u03bf\u03c5 \u03ba\u03ac\u03b8\u03b5 \u03ad\u03c4\u03bf\u03c5\u03c2, \u03b5\u03ba\u03c4\u03cc\u03c2 \u03b5\u03ac\u03bd \u03b7 \u03b1\u03af\u03c4\u03b7\u03c3\u03b7 \u03ad\u03c7\u03b5\u03b9 \u03ae\u03b4\u03b7 \u03c5\u03c0\u03bf\u03b2\u03bb\u03b7\u03b8\u03b5\u03af \u03ad\u03c9\u03c2 \u03c4\u03b9\u03c2 31 \u039f\u03ba\u03c4\u03c9\u03b2\u03c1\u03af\u03bf\u03c5.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0395\u03c0\u03af\u03c3\u03b7\u03bc\u03b7 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 NUB (InEK):<\/strong> <a href=\"https:\/\/www.g-drg.de\/neue-untersuchungs-und-behandlungsmethoden-nub\/drg\" target=\"_blank\" rel=\"noopener\">g-drg.de - \u0394\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 NUB \u03b3\u03b9\u03b1 \u0391\u03a4\u039c\u03a0<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0394\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 NUB (GKV-Spitzenverband):<\/strong> <a href=\"https:\/\/www.gkv-spitzenverband.de\/krankenversicherung\/krankenhaeuser\/drg_system\/neue_untersuchungs_und_behandlungsmethoden_nub\/neue_untersuchungs_und_behandlungsmethoden_nub.jsp\" target=\"_blank\" rel=\"noopener\">gkv-spitzenverband.de - NUB \u03c3\u03c4\u03b1 \u03bd\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03b1<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039b\u03b5\u03c0\u03c4\u03bf\u03bc\u03b5\u03c1\u03ae\u03c2 \u03b5\u03c0\u03b5\u03be\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1\u03c2 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03b5\u03b9\u03b4\u03b9\u03ba\u03cc \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03c3\u03bc\u03cc ATMP:<\/strong> <a href=\"https:\/\/reimbursement.institute\/nub-antrag\/\" target=\"_blank\" rel=\"noopener\">\u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae \u03c7\u03c1\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd.\u03b9\u03bd\u03c3\u03c4\u03b9\u03c4\u03bf\u03cd\u03c4\u03bf - \u0394\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1\u03c2 NUB<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0395\u03c0\u03b9\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 AOK NUB 2025 (\u03bc\u03b5 \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c4\u03c1\u03ad\u03c7\u03bf\u03c5\u03c3\u03b1 \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7):<\/strong> <a href=\"https:\/\/www.aok.de\/gp\/krankenhaus\/verguetung-drg\/nub\" target=\"_blank\" rel=\"noopener\">aok.de\/gp - NUB \u03c3\u03c4\u03b7 \u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae<\/a><\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Die_Realitat_Einzelfallantrage_und_Burokratie\"><\/span>\u0397 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1: \u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03ad\u03c2 \u03b1\u03b9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03b3\u03c1\u03b1\u03c6\u03b5\u03b9\u03bf\u03ba\u03c1\u03b1\u03c4\u03af\u03b1<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a0\u03b1\u03c1\u03ac \u03c4\u03b1 \u03c0\u03bf\u03c3\u03ac \u03b1\u03c0\u03bf\u03b6\u03b7\u03bc\u03af\u03c9\u03c3\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b1\u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9, \u03b7 \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c0\u03b9\u03bf \u03c0\u03b5\u03c1\u03af\u03c0\u03bb\u03bf\u03ba\u03b7 \u03b1\u03c0\u03cc \u03cc,\u03c4\u03b9 \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03bf\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03bc\u03bf\u03b9 \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03c3\u03bc\u03bf\u03af.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039c\u03ad\u03c7\u03c1\u03b9 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1, \u03c4\u03b1 \u03ba\u03ad\u03bd\u03c4\u03c1\u03b1 \u03ad\u03c0\u03c1\u03b5\u03c0\u03b5 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ac \u03bd\u03b1 \u03c5\u03c0\u03bf\u03b2\u03ac\u03bb\u03bf\u03c5\u03bd \u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03ae \u03b1\u03af\u03c4\u03b7\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03ba\u03ac\u03bb\u03c5\u03c8\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03cc\u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c5\u03c0\u03bf\u03c7\u03c1\u03b5\u03c9\u03c4\u03b9\u03ba\u03ae \u03b1\u03c3\u03c6\u03ac\u03bb\u03b9\u03c3\u03b7 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2.<br>\u0394\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c4\u03c5\u03c0\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7, \u03b1\u03c5\u03c4\u03cc\u03bc\u03b1\u03c4\u03b7 \u03ba\u03ac\u03bb\u03c5\u03c8\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03cc\u03c3\u03c4\u03bf\u03c5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03c5\u03c0\u03bf\u03c7\u03c1\u03b5\u03c9\u03c4\u03b9\u03ba\u03ae \u03b1\u03c3\u03c6\u03ac\u03bb\u03b9\u03c3\u03b7 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a0\u03b7\u03b3\u03ae:<\/strong> <a href=\"https:\/\/www.krebsinformationsdienst.de\/fachkreise\/nachrichten\/detail\/update-car-t-zell-therapie\" target=\"_blank\" rel=\"noopener\">\u03a5\u03c0\u03b7\u03c1\u03b5\u03c3\u03af\u03b1 \u0395\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf DKFZ - \u0395\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7 CAR-T: \u0394\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03b5\u03bd\u03b9\u03b1\u03af\u03b1\u03c2 \u03b1\u03af\u03c4\u03b7\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bc\u03c6\u03c9\u03bd\u03af\u03b5\u03c2 \u03ad\u03ba\u03c0\u03c4\u03c9\u03c3\u03b7\u03c2<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039a\u03b1\u03b8\u03ce\u03c2 \u03ad\u03bd\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd CAR-T \u03ba\u03bf\u03c3\u03c4\u03af\u03b6\u03b5\u03b9 \u03b1\u03c1\u03ba\u03b5\u03c4\u03ad\u03c2 \u03b5\u03ba\u03b1\u03c4\u03bf\u03bd\u03c4\u03ac\u03b4\u03b5\u03c2 \u03c7\u03b9\u03bb\u03b9\u03ac\u03b4\u03b5\u03c2 \u03b5\u03c5\u03c1\u03ce, \u03bf\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03c3\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03ba\u03ac\u03bb\u03c5\u03c8\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03cc\u03c3\u03c4\u03bf\u03c5\u03c2 \u03c0\u03c1\u03b9\u03bd \u03be\u03b5\u03ba\u03b9\u03bd\u03ae\u03c3\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1. \u039f \u03b5\u03c0\u03b9\u03ba\u03b5\u03c6\u03b1\u03bb\u03ae\u03c2 \u03b9\u03b1\u03c4\u03c1\u03cc\u03c2 Dr. Veit B\u00fccklein \u03b1\u03c0\u03cc \u03c4\u03bf LMU Klinikum M\u00fcnchen \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03ac\u03c6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03c3\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9: \u201e\u03a0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03ce\u03c3\u03bf\u03c5\u03bc\u03b5 \u03ad\u03bd\u03b1\u03bd \u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03c3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03ce\u03c3\u03bf\u03c5\u03bc\u03b5 \u03c0\u03bf\u03bb\u03bb\u03ac, \u03c0\u03bf\u03bb\u03bb\u03ac \u03ad\u03b3\u03b3\u03c1\u03b1\u03c6\u03b1, \u03b1\u03c0\u03cc \u03c4\u03bf \u0391 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03bf\u03c5 \u03b3\u03b9\u03b1\u03c4\u03c1\u03bf\u03cd \u03ad\u03c9\u03c2 \u03c4\u03bf \u0396 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03c3\u03c5\u03b3\u03ba\u03ad\u03bd\u03c4\u03c1\u03c9\u03c3\u03b7 \u03cc\u03bb\u03c9\u03bd \u03c4\u03c9\u03bd \u03b5\u03c5\u03c1\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd\u201c. \u0397 \u03b5\u03c0\u03af\u03c3\u03b7\u03bc\u03b7 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03bf\u03bd\u03bf\u03bc\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u201e\u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03b1\u03af\u03c4\u03b7\u03c3\u03b7\u03c2 \u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae\u03c2 \u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03ce\u03bd \u03b4\u03b1\u03c0\u03b1\u03bd\u03ce\u03bd\u201c.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a0\u03b7\u03b3\u03ae:<\/strong> <a href=\"https:\/\/pharma-fakten.de\/news\/car-t-zelltherapie-zukunftsversprechen-versus-burokratiemonster\/\" target=\"_blank\" rel=\"noopener\">Pharma facts - CAR-T: \u0397 \u03c5\u03c0\u03cc\u03c3\u03c7\u03b5\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bc\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03bf\u03c2 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03bf\u03c5 \u03c4\u03ad\u03c1\u03b1\u03c4\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03b3\u03c1\u03b1\u03c6\u03b5\u03b9\u03bf\u03ba\u03c1\u03b1\u03c4\u03af\u03b1\u03c2 (LMU Klinikum M\u00fcnchen, \u03a3\u03b5\u03c0\u03c4\u03ad\u03bc\u03b2\u03c1\u03b9\u03bf\u03c2 2024)<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03ba\u03b1\u03b8\u03b7\u03b3\u03ae\u03c4\u03c1\u03b9\u03b1 Dr. Marion Subklewe, \u03b5\u03c0\u03b9\u03ba\u03b5\u03c6\u03b1\u03bb\u03ae\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03bf\u03b3\u03c1\u03ac\u03bc\u03bc\u03b1\u03c4\u03bf\u03c2 CAR-T \u03c3\u03c4\u03bf LMU Klinikum M\u00fcnchen, \u03c3\u03c5\u03bd\u03bf\u03c8\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ae: \u201e\u0395\u03c1\u03b3\u03b1\u03b6\u03cc\u03bc\u03b1\u03c3\u03c4\u03b5 \u03bc\u03b5 \u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03b1. \u0394\u03b5\u03bd \u03ba\u03b1\u03c4\u03b1\u03bb\u03b1\u03b2\u03b1\u03af\u03bd\u03c9 \u03b3\u03b9\u03b1\u03c4\u03af \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c5\u03c0\u03bf\u03b2\u03ac\u03bb\u03bb\u03c9 \u03ba\u03ac\u03b8\u03b5 \u03c6\u03bf\u03c1\u03ac \u03be\u03b5\u03c7\u03c9\u03c1\u03b9\u03c3\u03c4\u03ae \u03b1\u03af\u03c4\u03b7\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03ad\u03bd\u03b1 \u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u201c. \u039f\u03b9 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b5\u03c2 \u03b1\u03c0\u03bf\u03b6\u03b7\u03bc\u03af\u03c9\u03c3\u03b7\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03b5\u03c0\u03af \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c1\u03cc\u03bd\u03c4\u03bf\u03c2 \u201e\u03ad\u03bd\u03b1 \u03bc\u03ad\u03c3\u03bf \u03c0\u03bf\u03c5 \u03b4\u03c5\u03c3\u03c7\u03b5\u03c1\u03b1\u03af\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03bf\u03b4\u03bf\u201c.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a0\u03b7\u03b3\u03ae:<\/strong> <a href=\"https:\/\/pharma-fakten.de\/news\/car-t-zelltherapien-optimale-versorgung-sieht-anders-aus\/\" target=\"_blank\" rel=\"noopener\">Pharma facts - CAR-T: \u0397 \u03b2\u03ad\u03bb\u03c4\u03b9\u03c3\u03c4\u03b7 \u03c6\u03c1\u03bf\u03bd\u03c4\u03af\u03b4\u03b1 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae (\u0391\u03c0\u03c1\u03af\u03bb\u03b9\u03bf\u03c2 2025)<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f \u03ba\u03b1\u03b8\u03b7\u03b3\u03b7\u03c4\u03ae\u03c2 Dr. Michael Hallek, \u03b4\u03b9\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae\u03c2 \u03c4\u03b7\u03c2 \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u0399 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u0395\u03c3\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03ae \u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03c3\u03c4\u03bf \u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03b9\u03b1\u03ba\u03cc \u039d\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03bf \u03c4\u03b7\u03c2 \u039a\u03bf\u03bb\u03c9\u03bd\u03af\u03b1\u03c2, \u03c0\u03c1\u03bf\u03c4\u03b5\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03bb\u03cd\u03c3\u03b7 \u03b8\u03b1 \u03ae\u03c4\u03b1\u03bd \u03bd\u03b1 \u03b1\u03bd\u03b1\u03c4\u03b5\u03b8\u03bf\u03cd\u03bd \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03bf\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03bc\u03b5 CAR-T \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c3\u03b5 \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b1 \u03ba\u03ad\u03bd\u03c4\u03c1\u03b1 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03b9\u03ce\u03c3\u03bf\u03c5\u03bd \u03c4\u03bf \u03ad\u03c1\u03b3\u03bf \u03c4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03b4\u03b5\u03af\u03be\u03bf\u03c5\u03bd \u03b1\u03c0\u03bf\u03b4\u03b5\u03b4\u03b5\u03b9\u03b3\u03bc\u03ad\u03bd\u03b7 \u03b5\u03c0\u03b9\u03c4\u03c5\u03c7\u03af\u03b1, \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03bd\u03b1 \u03b4\u03bf\u03b8\u03b5\u03af \u03c3\u03b5 \u03b1\u03c5\u03c4\u03ac \u03c4\u03b1 \u03ba\u03ad\u03bd\u03c4\u03c1\u03b1 \u03c4\u03bf \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03bf \u03c7\u03ad\u03c1\u03b9 \u03c3\u03c4\u03b7 \u03bb\u03ae\u03c8\u03b7 \u03b1\u03c0\u03bf\u03c6\u03ac\u03c3\u03b5\u03c9\u03bd \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1: \u201e\u03a4\u03cc\u03c4\u03b5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af\u03c4\u03b5 \u03bd\u03b1 \u03be\u03b5\u03c7\u03ac\u03c3\u03b5\u03c4\u03b5 \u03c4\u03b7 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03b1\u03bd\u03b1\u03b8\u03b5\u03ce\u03c1\u03b7\u03c3\u03b7\u03c2, \u03b4\u03b9\u03cc\u03c4\u03b9 \u03c0\u03bf\u03b9\u03bf\u03c2 \u03ac\u03bb\u03bb\u03bf\u03c2 \u03b5\u03ba\u03c4\u03cc\u03c2 \u03b1\u03c0\u03cc \u03b5\u03bc\u03ac\u03c2 \u03c5\u03c0\u03bf\u03c4\u03af\u03b8\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b8\u03b1 \u03ba\u03c1\u03af\u03bd\u03b5\u03b9 \u03b1\u03bd \u03bc\u03b9\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c9\u03c3\u03c4\u03ae \u03ae \u03cc\u03c7\u03b9;\u201c.\u201c<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a0\u03b7\u03b3\u03ae:<\/strong> <a href=\"https:\/\/pharma-fakten.de\/news\/car-t-zelltherapie-woran-es-noch-fehlt\/\" target=\"_blank\" rel=\"noopener\">Pharma facts - CAR-T: \u03a4\u03b9 \u03bb\u03b5\u03af\u03c0\u03b5\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b1 (\u0395\u03ba\u03b4\u03ae\u03bb\u03c9\u03c3\u03b7 \u03a0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03b9\u03b1\u03ba\u03cc \u039d\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03bf \u039a\u03bf\u03bb\u03c9\u03bd\u03af\u03b1\u03c2, \u0399\u03bf\u03cd\u03bb\u03b9\u03bf\u03c2 2025)<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0391\u03c0\u03cc \u03c4\u03b7 \u03c3\u03ba\u03bf\u03c0\u03b9\u03ac \u03c4\u03c9\u03bd \u03c0\u03b1\u03bd\u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03b9\u03b1\u03ba\u03ce\u03bd \u03bd\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03c9\u03bd, \u03c4\u03bf \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc \u03b4\u03b9\u03b1\u03c1\u03b8\u03c1\u03c9\u03c4\u03b9\u03ba\u03cc \u03c0\u03c1\u03cc\u03b2\u03bb\u03b7\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03bf \u03bd\u03bf\u03bc\u03bf\u03b8\u03ad\u03c4\u03b7\u03c2 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03ba\u03b1\u03bb\u03cd\u03c8\u03b5\u03b9 \u03c4\u03bf \u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03cc \u03ba\u03b5\u03bd\u03cc \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03b7\u03c2 \u03ad\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03b5\u03bd\u03cc\u03c2 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u03b5\u03b3\u03b3\u03c5\u03b7\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b4\u03b9\u03ba\u03b1\u03b9\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae\u03c2 \u03c4\u03c9\u03bd \u03bd\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03c9\u03bd. \u03a3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bd\u03ad\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03ce\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03b9\u03ce\u03bd, \u03bf \u03bf\u03b9\u03ba\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03cc\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b1 \u03bd\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd \u03c5\u03c8\u03b7\u03bb\u03cc\u03c2 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b5 \u03b8\u03ad\u03c3\u03b7 \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03b2\u03ac\u03bb\u03bb\u03bf\u03c5\u03bd \u03c0\u03c1\u03bf\u03ba\u03b1\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a0\u03b7\u03b3\u03ae:<\/strong> <a href=\"https:\/\/www.uniklinika.de\/gesundheitspolitischethemen\/car-t-zelltherapie\/\" target=\"_blank\" rel=\"noopener\">Uniklinika.de - \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd CAR-T: \u03b6\u03ae\u03c4\u03b7\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 \u03b1\u03c0\u03bf\u03b6\u03b7\u03bc\u03af\u03c9\u03c3\u03b7\u03c2<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f\u03b9 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c5\u03bd\u03ad\u03c0\u03b5\u03b9\u03b5\u03c2 \u03b1\u03c5\u03c4\u03ce\u03bd \u03c4\u03c9\u03bd \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03b5\u03c1\u03ae\u03c3\u03b5\u03c9\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b5\u03c4\u03c1\u03ae\u03c3\u03b9\u03bc\u03b5\u03c2: \u03b7 \u03b1\u03bd\u03b1\u03bc\u03bf\u03bd\u03ae \u03b5\u03bd\u03cc\u03c2 \u03bc\u03ae\u03bd\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 CAR-T \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c5\u03be\u03ae\u03c3\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ae \u03b8\u03bd\u03b7\u03c3\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03c4\u03ac 6,2%. \u039f\u03c0\u03bf\u03b9\u03b1\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03c3\u03b2\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd CAR-T \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03ac\u03bc\u03b5\u03c3\u03bf \u03b1\u03bd\u03c4\u03af\u03ba\u03c4\u03c5\u03c0\u03bf \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c4\u03c5\u03c7\u03af\u03b1 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a0\u03b7\u03b3\u03ae:<\/strong> <a href=\"https:\/\/pharma-fakten.de\/news\/car-t-zelltherapien-optimale-versorgung-sieht-anders-aus\/\" target=\"_blank\" rel=\"noopener\">Pharma-Fakten \/ \u0399\u03bd\u03c3\u03c4\u03b9\u03c4\u03bf\u03cd\u03c4\u03bf IQVIA - CAR-T: \u0397 \u03b2\u03ad\u03bb\u03c4\u03b9\u03c3\u03c4\u03b7 \u03c6\u03c1\u03bf\u03bd\u03c4\u03af\u03b4\u03b1 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae (\u03bc\u03b5 \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac \u03c3\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c4\u03b7\u03c2 IQVIA)<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03ac\u03bb\u03bb\u03bf \u03b4\u03b9\u03b1\u03c1\u03b8\u03c1\u03c9\u03c4\u03b9\u03ba\u03cc \u03c0\u03c1\u03cc\u03b2\u03bb\u03b7\u03bc\u03b1: \u03c0\u03ac\u03bd\u03c9 \u03b1\u03c0\u03cc 160 \u03bd\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c5\u03c0\u03bf\u03b2\u03ac\u03bb\u03b5\u03b9 \u03b1\u03b9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 NUB \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 CAR-T - \u03b1\u03bb\u03bb\u03ac \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac \u03c4\u03bf\u03c5\u03c2 \u03b4\u03cc\u03b8\u03b7\u03ba\u03b5 \u03bc\u03cc\u03bd\u03bf \u03c4\u03bf \u03ba\u03b1\u03b8\u03b5\u03c3\u03c4\u03ce\u03c2 NUB 4, \u03c0\u03c1\u03ac\u03b3\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03bf \u0399\u039a\u0391 \u03b4\u03b5\u03bd \u03c5\u03c0\u03bf\u03c7\u03c1\u03b5\u03bf\u03cd\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c8\u03b5\u03b9 \u03c4\u03bf \u03ba\u03cc\u03c3\u03c4\u03bf\u03c2 \u03c9\u03c2 \u03bc\u03ad\u03c1\u03bf\u03c2 \u03c4\u03c9\u03bd \u03c3\u03c5\u03bc\u03c6\u03c9\u03bd\u03b9\u03ce\u03bd NUB.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a0\u03b7\u03b3\u03ae:<\/strong> <a href=\"https:\/\/www.vdek.com\/magazin\/ausgaben\/2018-1112\/politik_car_t_zelltherapie.html\" target=\"_blank\" rel=\"noopener\">VDEK - \u0395\u03c0\u03b1\u03bd\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1: \u03ba\u03b1\u03b8\u03b5\u03c3\u03c4\u03ce\u03c2 NUB \u03ba\u03b1\u03b9 \u03b8\u03ad\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c0\u03bf\u03b6\u03b7\u03bc\u03af\u03c9\u03c3\u03b7\u03c2 \u03bc\u03b5 CAR-T<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f \u03ba\u03b1\u03b8\u03b7\u03b3\u03b7\u03c4\u03ae\u03c2 Subklewe \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03ac\u03c6\u03b5\u03b9 \u03ad\u03bd\u03b1 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c0\u03b1\u03c1\u03ac\u03bb\u03bf\u03b3\u03bf \u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03cc \u03c0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae \u03bd\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03b9\u03b1\u03ba\u03ae \u03b6\u03c9\u03ae: \u201e\u03a0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03bc\u03bf\u03c5 \u03bb\u03ad\u03bd\u03b5 \u03cc\u03c4\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03bf\u03bd\u03c4\u03ac \u03bc\u03bf\u03c5 24 \u03ce\u03c1\u03b5\u03c2 \u03c4\u03bf 24\u03c9\u03c1\u03bf, \u03c0\u03b1\u03c1\u03cc\u03bb\u03bf \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03ad\u03c7\u03c9 \u03c7\u03c1\u03b5\u03b9\u03b1\u03c3\u03c4\u03b5\u03af \u03c0\u03bf\u03c4\u03ad \u03ad\u03bd\u03b1\u03bd \u03c4\u03b1 \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03c0\u03ad\u03bd\u03c4\u03b5 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1\u201c.\u201c<br>\u039f\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03bf\u03b9\u03bf\u03c4\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c1\u03b8\u03c1\u03c9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03c0\u03b1\u03b9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03bd\u03cc\u03b7\u03bc\u03b1, \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03c0\u03b9\u03c4\u03c1\u03b1\u03c0\u03b5\u03af \u03bd\u03b1 \u03be\u03b5\u03c6\u03cd\u03b3\u03bf\u03c5\u03bd \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf, \u03cc\u03c0\u03c9\u03c2 \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a0\u03b7\u03b3\u03ae:<\/strong> <a href=\"https:\/\/pharma-fakten.de\/news\/car-t-zelltherapie-zukunftsversprechen-versus-burokratiemonster\/\" target=\"_blank\" rel=\"noopener\">Pharma facts - CAR-T: \u0397 \u03c5\u03c0\u03cc\u03c3\u03c7\u03b5\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bc\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03bf\u03c2 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03bf\u03c5 \u03c4\u03ad\u03c1\u03b1\u03c4\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03b3\u03c1\u03b1\u03c6\u03b5\u03b9\u03bf\u03ba\u03c1\u03b1\u03c4\u03af\u03b1\u03c2<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0395\u03c0\u03b9\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03ba\u03ad\u03bd\u03c4\u03c1\u03c9\u03bd CAR-T \u03c3\u03c4\u03b7 \u0393\u03b5\u03c1\u03bc\u03b1\u03bd\u03af\u03b1<\/strong> (\u03b3\u03b9\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03c0\u03ad\u03bc\u03c0\u03bf\u03bd\u03c4\u03b5\u03c2 \u03b9\u03b1\u03c4\u03c1\u03bf\u03cd\u03c2):<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.novartis.com\/de-de\/uebersicht-behandelnder-car-t-zentren-deutschland\" target=\"_blank\" rel=\"noopener\">Novartis - \u0395\u03c0\u03b9\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03ba\u03ad\u03bd\u03c4\u03c1\u03c9\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 CAR-T \u03c3\u03c4\u03b7 \u0393\u03b5\u03c1\u03bc\u03b1\u03bd\u03af\u03b1 (Kymriah)<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.lmu-klinikum.de\/aktuelles\/pressemitteilungen\/funf-jahre-car-t-zelltherapie-am-lmu-klinikum-nbsp\/c52167393f8351f2\" target=\"_blank\" rel=\"noopener\">LMU Klinikum M\u00fcnchen - \u03a0\u03ad\u03bd\u03c4\u03b5 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 CAR-T: \u03a0\u03c1\u03cc\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b1\u03c6\u03ae<\/a> <\/li>\n\n\n\n<li><a href=\"https:\/\/www.dkfz.de\/de\/presse\/pressemitteilungen\/2020\/dkfz-pm-20-40-CAR-T-Zell-Therapien-erhebliche-Kostenersparnis-moeglich.php\" target=\"_blank\" rel=\"noopener\">DKFZ - \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 CAR T-cell: \u03b5\u03be\u03bf\u03b9\u03ba\u03bf\u03bd\u03cc\u03bc\u03b7\u03c3\u03b7 \u03ba\u03cc\u03c3\u03c4\u03bf\u03c5\u03c2 \u03bc\u03ad\u03c3\u03c9 \u03b5\u03c3\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03ae\u03c2 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae\u03c2<\/a><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Das_%E2%80%9EPay-for-Outcome%E2%80%9C-Modell\"><\/span>\u03a4\u03bf \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03bf \u201e\u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ae \u03b3\u03b9\u03b1 \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1\u201c<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"> (\u03b1\u03c0\u03bf\u03b6\u03b7\u03bc\u03af\u03c9\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03b5\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b1\u03c0\u03cc\u03b4\u03bf\u03c3\u03b7)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a9\u03c2 \u03ba\u03b1\u03b9\u03bd\u03bf\u03c4\u03cc\u03bc\u03bf\u03c2 \u03b5\u03bd\u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 \u03bb\u03cd\u03c3\u03b7, \u03c4\u03b1 \u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03ac \u03c4\u03b1\u03bc\u03b5\u03af\u03b1 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b9\u03c3\u03b7\u03c2 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2 \u03c3\u03c5\u03bc\u03c6\u03ce\u03bd\u03b7\u03c3\u03b1\u03bd \u03c4\u03b1 \u03bb\u03b5\u03b3\u03cc\u03bc\u03b5\u03bd\u03b1 <strong>\u03a3\u03c5\u03bc\u03b2\u03ac\u03c3\u03b5\u03b9\u03c2 \"\u03a0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ae \u03b3\u03b9\u03b1 \u03b1\u03c0\u03cc\u03b4\u03bf\u03c3\u03b7<\/strong> \u03ba\u03bb\u03b5\u03b9\u03c3\u03c4\u03ac:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 Novartis \u03ba\u03b1\u03b9 \u03b7 GWQ ServicePlus \u03c3\u03c5\u03bd\u03ae\u03c8\u03b1\u03bd \u03ad\u03bd\u03b1 \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03bf \u03b1\u03c0\u03bf\u03b6\u03b7\u03bc\u03af\u03c9\u03c3\u03b7\u03c2 \u03b2\u03ac\u03c3\u03b5\u03b9 \u03b5\u03c0\u03b9\u03b4\u03cc\u03c3\u03b5\u03c9\u03bd \u03b3\u03b9\u03b1 \u03c4\u03bf Kymriah, \u03c4\u03b7\u03bd \u03c0\u03c1\u03ce\u03c4\u03b7 \u03c3\u03c5\u03bc\u03c6\u03c9\u03bd\u03af\u03b1 \u03c4\u03bf\u03c5 \u03b5\u03af\u03b4\u03bf\u03c5\u03c2 \u03c4\u03b7\u03c2 \u03c3\u03c4\u03b7 \u0393\u03b5\u03c1\u03bc\u03b1\u03bd\u03af\u03b1:<br>\u0397 Novartis \u03b8\u03b1 \u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03ad\u03c8\u03b5\u03b9 \u03bc\u03ad\u03c1\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03ba\u03cc\u03c3\u03c4\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03b5\u03ac\u03bd \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03c0\u03b5\u03b8\u03ac\u03bd\u03b5\u03b9 \u03b1\u03c0\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b5\u03bd\u03c4\u03cc\u03c2 \u03ba\u03b1\u03b8\u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03cc\u03b4\u03bf\u03c5 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1. <br>\u0397 \u03c0\u03b1\u03c1\u03ac\u03bc\u03b5\u03c4\u03c1\u03bf\u03c2 \u03ad\u03ba\u03b2\u03b1\u03c3\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03cc\u03bc\u03b5\u03bd\u03bf\u03c5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03bf \u03b1\u03c5\u03c4\u03cc \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03bf: \u03b7 Techniker Krankenkasse \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b1 \u03c4\u03b1\u03bc\u03b5\u03af\u03b1 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b9\u03c3\u03b7\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03b1\u03c2 \u03c5\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c4\u03c9\u03bd \u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b1\u03bd \u03c4\u03bf \u03c0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1 \u03bc\u03b5 \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b5\u03c2 \u03c3\u03c5\u03bc\u03c6\u03c9\u03bd\u03af\u03b5\u03c2.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Welche_CAR-T-Produkte_sind_in_Deutschland_erstattungsfahig\"><\/span>\u03a0\u03bf\u03b9\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03b1 CAR-T \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03b9\u03bb\u03ad\u03be\u03b9\u03bc\u03b1 \u03b3\u03b9\u03b1 \u03b1\u03c0\u03bf\u03b6\u03b7\u03bc\u03af\u03c9\u03c3\u03b7 \u03c3\u03c4\u03b7 \u0393\u03b5\u03c1\u03bc\u03b1\u03bd\u03af\u03b1;<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u03a0\u03c1\u03bf\u03ca\u03cc\u03bd<\/th><th>\u0388\u03bd\u03b4\u03b5\u03b9\u03be\u03b7<\/th><th>\u039a\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 GKV<\/th><\/tr><\/thead><tbody><tr><td><strong>Kymriah<\/strong> (Tisagenlecleucel)<\/td><td>\u03a0\u03b1\u03b9\u03b4\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae B-ALL, DLBCL, FL<\/td><td>\u2705 \u03a0\u03bf\u03c3\u03cc \u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae\u03c2 \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b1\u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 (\u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03a3\u03b5\u03c0\u03c4\u03ad\u03bc\u03b2\u03c1\u03b9\u03bf 2019)<\/td><\/tr><tr><td><strong>Yescarta<\/strong> (Axicabtagene-cel)<\/td><td>DLBCL, PMBCL, FL, tFL<\/td><td>\u2705 \u0394\u03b9\u03b1\u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03c0\u03bf\u03c3\u03cc \u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae\u03c2<\/td><\/tr><tr><td><strong>Tecartus<\/strong> (Brexucabtagene-cel)<\/td><td>MCL, \u03b5\u03bd\u03b7\u03bb\u03af\u03ba\u03c9\u03bd B-ALL<\/td><td>\u0394\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 NUB \u03c3\u03b5 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7\/\u03bf\u03bb\u03bf\u03ba\u03bb\u03b7\u03c1\u03ce\u03b8\u03b7\u03ba\u03b5<\/td><\/tr><tr><td><strong>Breyanzi<\/strong> (Lisocabtagene-cel)<\/td><td>DLBCL, CLL, FL<\/td><td>\u0395\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u0395\u039c\u0391- \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 NUB<\/td><\/tr><tr><td><strong>Abecma<\/strong> (Idecabtagene-cel)<\/td><td>\u03a0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03cc \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1<\/td><td>\u0395\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u0395\u039c\u0391- \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 NUB<\/td><\/tr><tr><td><strong>Carvykti<\/strong> (Ciltacabtagene-cel)<\/td><td>\u03a0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03cc \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1<\/td><td>\u0395\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u0395\u039c\u0391- \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 NUB<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03cb\u03c0\u03cc\u03b8\u03b5\u03c3\u03b7 \u03c3\u03b5 \u03ba\u03ac\u03b8\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7<\/strong><br>\u03a4\u03bf \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03ba\u03ad\u03bd\u03c4\u03c1\u03bf \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u03c0\u03bb\u03b7\u03c1\u03bf\u03cd\u03bd \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae\u03c1\u03b9\u03b1 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae \u03b4\u03b9\u03b1\u03c3\u03c6\u03ac\u03bb\u03b9\u03c3\u03b7\u03c2 \u03c0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 ATMP \u03c4\u03bf\u03c5 G-BA<\/li>\n\n\n\n<li>\u0394\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd FACT\/JACIE<\/li>\n\n\n\n<li>\u03ba\u03b1\u03b9 \u03bd\u03b1 \u03c0\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03c9\u03c2 \u03ba\u03ad\u03bd\u03c4\u03c1\u03bf CAR-T.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u039c\u03cc\u03bd\u03bf \u03c4\u03cc\u03c4\u03b5 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c3\u03c5\u03bc\u03c6\u03c9\u03bd\u03b7\u03b8\u03bf\u03cd\u03bd \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03c4\u03b9\u03bc\u03bf\u03bb\u03bf\u03b3\u03b7\u03b8\u03bf\u03cd\u03bd \u03c4\u03b1 \u03c4\u03ad\u03bb\u03b7 NUB.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Kimmtrak_Tebentafusp_%E2%80%93_Sonderfall\"><\/span>Kimmtrak (Tebentafusp) - \u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf Kimmtrak \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03b1\u03bb\u03bb\u03ac \u03ad\u03bd\u03b1 <strong>\u0392\u03b9\u03bf\u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae<\/strong> \u03ba\u03b1\u03b9 \u03c5\u03c0\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 AMNOG \u03cc\u03c0\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5. \u03a7\u03bf\u03c1\u03b7\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b5\u03be\u03c9\u03bd\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03b9\u03b1\u03ba\u03ae \u03b2\u03ac\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03b6\u03b7\u03bc\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03c9\u03bd \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03bd \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03bf\u03b4\u03ce\u03bd \u03c7\u03c1\u03ad\u03c9\u03c3\u03b7\u03c2, \u03b1\u03bb\u03bb\u03ac \u03bc\u03cc\u03bd\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7 (<strong>HLA-A*02:01-\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03bc\u03b5\u03bb\u03ac\u03bd\u03c9\u03bc\u03b1 \u03c4\u03bf\u03c5 uveal<\/strong>, \u03c0\u03c1\u03ce\u03c4\u03b7 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"TIL-Therapie_Lifileucel_Amtagvi_%E2%80%93_In_Deutschland_derzeit_NICHT_erstattungsfahig\"><\/span>\u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 TIL (Lifileucel \/ Amtagvi) - \u0395\u03c0\u03af \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c1\u03cc\u03bd\u03c4\u03bf\u03c2 \u0394\u0395\u039d \u03b1\u03c0\u03bf\u03b6\u03b7\u03bc\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u0393\u03b5\u03c1\u03bc\u03b1\u03bd\u03af\u03b1<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0391\u03c5\u03c4\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c0\u03b9\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u0397\u03a0\u0391.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 \u03b5\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b1 <em>Iovance<\/em> \u03b1\u03c0\u03ad\u03c3\u03c5\u03c1\u03b5 \u03c4\u03b7\u03bd \u03b1\u03af\u03c4\u03b7\u03c3\u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7\u03c2 \u03ac\u03b4\u03b5\u03b9\u03b1\u03c2 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1\u03c2 \u03c3\u03c4\u03bf\u03bd \u0395\u039c\u0391 \u03c3\u03c4\u03b9\u03c2 22 \u0399\u03bf\u03c5\u03bb\u03af\u03bf\u03c5 2025. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f EMA \u03b5\u03af\u03c7\u03b5 \u03b1\u03bd\u03b7\u03c3\u03c5\u03c7\u03af\u03b5\u03c2 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b7\u03bd \u03ba\u03cd\u03c1\u03b9\u03b1 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ad\u03c2 \u03b1\u03bd\u03b7\u03c3\u03c5\u03c7\u03af\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03c3\u03c4\u03b7\u03ba\u03b5 \u03bc\u03b5 \u03b8\u03b1\u03bd\u03ac\u03c4\u03bf\u03c5\u03c2.<br>\u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03bf \u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03c4\u03ae\u03c2 \u03b4\u03b5\u03bd \u03b5\u03af\u03c7\u03b5 \u03b5\u03c0\u03b1\u03c1\u03ba\u03ae \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03af\u03c9\u03c3\u03b7 GMP. <a href=\"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2025.43.16_suppl.TPS2673\" target=\"_blank\" rel=\"noreferrer noopener\">\u0391\u03bc\u03b5\u03c1\u03b9\u03ba\u03b1\u03bd\u03b9\u03ba\u03ae \u0395\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b1 \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u039f\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0397 Iovance \u03b1\u03bd\u03b1\u03c0\u03c4\u03cd\u03c3\u03c3\u03b5\u03b9 \u03b5\u03c0\u03af \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c1\u03cc\u03bd\u03c4\u03bf\u03c2 \u03bc\u03b9\u03b1 \u03bd\u03ad\u03b1 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 \u03c4\u03bf\u03bd EMA \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03bb\u03ac\u03b2\u03b5\u03b9 \u03ac\u03b4\u03b5\u03b9\u03b1 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1\u03c2 \u03c3\u03c4\u03b7\u03bd \u0395\u0395 \u03b3\u03b9\u03b1 \u03c4\u03bf Amtagvi. \u0393\u03b9\u03b1 \u03c4\u03bf \u0397\u03bd\u03c9\u03bc\u03ad\u03bd\u03bf \u0392\u03b1\u03c3\u03af\u03bb\u03b5\u03b9\u03bf, \u03b7 \u03ad\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03b1\u03bd\u03b1\u03bc\u03ad\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c4\u03bf \u03c0\u03c1\u03ce\u03c4\u03bf \u03b5\u03be\u03ac\u03bc\u03b7\u03bd\u03bf \u03c4\u03bf\u03c5 2026- \u03b7 \u0391\u03c5\u03c3\u03c4\u03c1\u03b1\u03bb\u03af\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03c7\u03bf\u03c1\u03b7\u03b3\u03ae\u03c3\u03b5\u03b9 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03ba\u03b1\u03c4\u03ac \u03c0\u03c1\u03bf\u03c4\u03b5\u03c1\u03b1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1. <a href=\"https:\/\/www.globenewswire.com\/de\/news-release\/2025\/03\/27\/3050384\/0\/en\/Immatics-Announces-Full-Year-2024-Financial-Results-and-Business-Update.html\" target=\"_blank\" rel=\"noreferrer noopener\">GlobeNewswire<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u0393\u03b5\u03c1\u03bc\u03b1\u03bd\u03af\u03b1:<\/strong> \u03a4\u03bf Lifileucel \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03af \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c1\u03cc\u03bd\u03c4\u03bf\u03c2 \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03bf \u03c3\u03c4\u03b7\u03bd \u0395\u0395 <strong>\u0394\u03b5\u03bd \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03ad\u03c6\u03b5\u03c4\u03b1\u03b9<\/strong>. \u039f\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03c0\u03b9\u03b8\u03c5\u03bc\u03bf\u03cd\u03bd \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03b5\u03c0\u03af \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c1\u03cc\u03bd\u03c4\u03bf\u03c2 \u03bd\u03b1 \u03c4\u03b7 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c3\u03c4\u03b9\u03c2 \u0397\u03a0\u0391, \u03bc\u03b5 \u03b4\u03b9\u03ba\u03ac \u03c4\u03bf\u03c5\u03c2 \u03ad\u03be\u03bf\u03b4\u03b1 \u03ae \u03c3\u03c4\u03bf \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03b4\u03bf\u03ba\u03b9\u03bc\u03ce\u03bd.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"TCR-T-Therapien_Afami-cel_Tecelra_%E2%80%93_In_Europa_nicht_zugelassen\"><\/span>TCR-T \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 (Afami-cel \/ Tecelra) - \u0394\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03b3\u03ba\u03c1\u03b9\u03b8\u03b5\u03af \u03c3\u03c4\u03b7\u03bd \u0395\u03c5\u03c1\u03ce\u03c0\u03b7<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf Afamitresgene autoleucel (Tecelra) \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03af \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c1\u03cc\u03bd\u03c4\u03bf\u03c2 <strong>\u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03c4\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c3\u03c4\u03b9\u03c2 \u0397\u03a0\u0391<\/strong> (FDA, \u0391\u03cd\u03b3\u03bf\u03c5\u03c3\u03c4\u03bf\u03c2 2024). \u0394\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03c5\u03c0\u03bf\u03b2\u03bb\u03b7\u03b8\u03b5\u03af \u03b1\u03ba\u03cc\u03bc\u03b7 \u03b1\u03af\u03c4\u03b7\u03c3\u03b7 \u03c3\u03c4\u03bf\u03bd EMA.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03c5\u03bd\u03b5\u03c0\u03ce\u03c2, \u03c3\u03c4\u03b7 \u0393\u03b5\u03c1\u03bc\u03b1\u03bd\u03af\u03b1 \u03b9\u03c3\u03c7\u03cd\u03bf\u03c5\u03bd \u03c4\u03b1 \u03b5\u03be\u03ae\u03c2: \u03ba\u03b1\u03bc\u03af\u03b1 \u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae \u03c7\u03c1\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd, \u03ba\u03b1\u03bc\u03af\u03b1 \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03cc\u03c3\u03b2\u03b1\u03c3\u03b7, \u03bc\u03cc\u03bd\u03bf \u03bc\u03ad\u03c3\u03c9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03b4\u03bf\u03ba\u03b9\u03bc\u03ce\u03bd \u03ae \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03c9\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ce\u03bd \u03b4\u03bf\u03ba\u03b9\u03bc\u03ce\u03bd (\u03cc\u03c0\u03c9\u03c2 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 Mailo \u03c3\u03c4\u03bf KiTZ \u03c4\u03b7\u03c2 \u03a7\u03b1\u03ca\u03b4\u03b5\u03bb\u03b2\u03ad\u03c1\u03b3\u03b7\u03c2).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Was_tun_wenn_die_Kasse_ablehnt_Rechtliche_Moglichkeiten\"><\/span>\u03a4\u03b9 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03ba\u03ac\u03bd\u03b5\u03c4\u03b5 \u03b5\u03ac\u03bd \u03b7 \u03b1\u03c3\u03c6\u03b1\u03bb\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b5\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b1 \u03b1\u03c1\u03bd\u03b7\u03b8\u03b5\u03af; \u039d\u03bf\u03bc\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0395\u03ac\u03bd \u03ad\u03bd\u03b1\u03c2 \u03bd\u03cc\u03bc\u03b9\u03bc\u03bf\u03c2 \u03b1\u03c3\u03c6\u03b1\u03bb\u03b9\u03c3\u03c4\u03ae\u03c2 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2 \u03b1\u03c1\u03bd\u03b7\u03b8\u03b5\u03af \u03bd\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c8\u03b5\u03b9 \u03c4\u03bf \u03ba\u03cc\u03c3\u03c4\u03bf\u03c2 \u03bc\u03b9\u03b1\u03c2 \u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u0395\u039c\u0391 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2, \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03bf\u03b9 \u03b1\u03ba\u03cc\u03bb\u03bf\u03c5\u03b8\u03b5\u03c2 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0388\u03bd\u03c3\u03c4\u03b1\u03c3\u03b7 (\u00a7 78 SGB V)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u03a5\u03c0\u03bf\u03b2\u03ac\u03bb\u03b5\u03c4\u03b5 \u03b5\u03b3\u03b3\u03c1\u03ac\u03c6\u03c9\u03c2 \u03ad\u03bd\u03c3\u03c4\u03b1\u03c3\u03b7 \u03b5\u03bd\u03c4\u03cc\u03c2 4 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03c9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b1\u03c0\u03cc\u03c1\u03c1\u03b9\u03c8\u03b7.<\/li>\n\n\n\n<li>\u0397 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03bf \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc\u03c2 \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03c0\u03b9\u03c3\u03c5\u03bd\u03ac\u03c8\u03bf\u03c5\u03bd \u03bb\u03b5\u03c0\u03c4\u03bf\u03bc\u03b5\u03c1\u03ae \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03ad\u03ba\u03b8\u03b5\u03c3\u03b7.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039a\u03bf\u03b9\u03bd\u03c9\u03bd\u03b9\u03ba\u03ae \u03b4\u03b9\u03ba\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0395\u03ac\u03bd \u03b7 \u03b1\u03c0\u03cc\u03c6\u03b1\u03c3\u03b7 \u03b5\u03be\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae, \u03ba\u03b1\u03c4\u03b1\u03b8\u03ad\u03c3\u03c4\u03b5 \u03c0\u03c1\u03bf\u03c3\u03c6\u03c5\u03b3\u03ae \u03c3\u03c4\u03bf \u03b1\u03c1\u03bc\u03cc\u03b4\u03b9\u03bf \u03ba\u03bf\u03b9\u03bd\u03c9\u03bd\u03b9\u03ba\u03cc \u03b4\u03b9\u03ba\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf.<\/li>\n\n\n\n<li>\u03a3\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03b1\u03c0\u03b5\u03b9\u03bb\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b6\u03c9\u03ae \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03b9\u03ce\u03bd, \u03ad\u03bd\u03b1 <strong>\u03c0\u03c1\u03bf\u03c3\u03c9\u03c1\u03b9\u03bd\u03ae \u03bd\u03bf\u03bc\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c3\u03af\u03b1<\/strong> \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c5\u03c0\u03bf\u03b2\u03bb\u03b7\u03b8\u03b5\u03af \u03b1\u03af\u03c4\u03b7\u03c3\u03b7, <br>\u03c4\u03bf \u03b4\u03b9\u03ba\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c4\u03ac\u03be\u03b5\u03b9 \u03c0\u03c1\u03bf\u03c3\u03c9\u03c1\u03b9\u03bd\u03ac \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03bb\u03b7\u03c8\u03b7 \u03c4\u03c9\u03bd \u03b4\u03b9\u03ba\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03b5\u03be\u03cc\u03b4\u03c9\u03bd.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u00a7 \u03a4\u03bc\u03ae\u03bc\u03b1 2 (1\u03b1) SGB V (\u03c8\u03ae\u03c6\u03b9\u03c3\u03bc\u03b1 Nikolaus)<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03b1\u03c0\u03b5\u03b9\u03bb\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b6\u03c9\u03ae \u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03ad\u03bb\u03bb\u03b5\u03b9\u03c8\u03b7\u03c2 \u03ba\u03b1\u03b8\u03b9\u03b5\u03c1\u03c9\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2, \u03bf\u03b9 \u03b1\u03c3\u03c6\u03b1\u03bb\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03b9 \u03b4\u03b9\u03ba\u03b1\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03bc\u03b7 \u03ba\u03b1\u03b8\u03b9\u03b5\u03c1\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, \u03b5\u03ac\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03c0\u03c1\u03bf\u03bf\u03c0\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03ae \u03b1\u03b9\u03c3\u03b8\u03b7\u03c4\u03ae\u03c2 \u03b1\u03bd\u03b1\u03ba\u03bf\u03cd\u03c6\u03b9\u03c3\u03b7\u03c2. \u0391\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03cc \u03bd\u03bf\u03bc\u03b9\u03ba\u03cc \u03bc\u03ad\u03c3\u03bf \u03b3\u03b9\u03b1 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03bf\u03b9 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03c1\u03bf\u03c3\u03c0\u03ac\u03b8\u03b5\u03b9\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03bf\u03af \u03c0\u03cc\u03c1\u03bf\u03b9:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.g-ba.de\/themen\/arzneimittel\/arzneimittel-richtlinie-anlagen\/nutzenbewertung-131e\/\" target=\"_blank\" rel=\"noopener\">G-BA \u03b5\u03ba\u03c4\u03b9\u03bc\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03bf\u03c6\u03ad\u03bb\u03bf\u03c5\u03c2 \u03c4\u03c9\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03b9\u03ce\u03bd \u03bc\u03b5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.dgho.de\/arbeitskreise\/a-g\/drg-gesundheitsoekonomie\/nub-2025\/nub-2025\" target=\"_blank\" rel=\"noopener\">\u03a0\u03c1\u03cc\u03c4\u03c5\u03c0\u03b1 DGHO NUB 2025<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.krebsinformationsdienst.de\/fachkreise\/nachrichten\/detail\/update-car-t-zell-therapie\" target=\"_blank\" rel=\"noopener\">\u03a5\u03c0\u03b7\u03c1\u03b5\u03c3\u03af\u03b1 \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf DKFZ - CAR-T \u03ba\u03b1\u03b9 GKV<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pharma-fakten.de\/news\/car-t-zelltherapie-woran-es-noch-fehlt\/\" target=\"_blank\" rel=\"noopener\">\u03a6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ac \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c4\u03b1: CAR-T<\/a><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Osterreich\"><\/span>\u0391\u03c5\u03c3\u03c4\u03c1\u03af\u03b1<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0391\u03c5\u03c3\u03c4\u03c1\u03af\u03b1:<\/strong> \u0397 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 CAR-T \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03ae\u03c6\u03b8\u03b7\u03ba\u03b5 \u03c3\u03c4\u03bf\u03bd \u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf \u03c5\u03c0\u03b7\u03c1\u03b5\u03c3\u03b9\u03ce\u03bd \u03c4\u03bf\u03c5 LKF \u03c3\u03c4\u03b7\u03bd \u0391\u03c5\u03c3\u03c4\u03c1\u03af\u03b1 \u03c4\u03b7\u03bd 1\u03b7 \u0399\u03b1\u03bd\u03bf\u03c5\u03b1\u03c1\u03af\u03bf\u03c5 2020 (\u03bf\u03bc\u03ac\u03b4\u03b1 MEL22.30: \u201e\u03a7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd\u201c) - \u03b5\u03c0\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03c1\u03c5\u03b8\u03bc\u03af\u03c3\u03c4\u03b7\u03ba\u03b5 \u03bd\u03c9\u03c1\u03af\u03c4\u03b5\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03b1\u03c6\u03ad\u03c3\u03c4\u03b5\u03c1\u03b1 \u03b1\u03c0\u03cc \u03cc,\u03c4\u03b9 \u03c3\u03c4\u03b7 \u0393\u03b5\u03c1\u03bc\u03b1\u03bd\u03af\u03b1. <a href=\"https:\/\/www.clinicaltrialvanguard.com\/news\/t-knife-files-for-phase-1-trial-of-prame-t-cell-therapy\/\" target=\"_blank\" rel=\"noreferrer noopener\">Clinicaltrialvanguard<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Schweiz\"><\/span>\u0395\u03bb\u03b2\u03b5\u03c4\u03af\u03b1<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0395\u03bb\u03b2\u03b5\u03c4\u03af\u03b1:<\/strong> \u0391\u03c0\u03bf\u03b6\u03b7\u03bc\u03af\u03c9\u03c3\u03b7 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03bf\u03c5 KVG (\u03bd\u03cc\u03bc\u03bf\u03c2 \u03c0\u03b5\u03c1\u03af \u03b1\u03c3\u03c6\u03ac\u03bb\u03b9\u03c3\u03b7\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03b1\u03c2) \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03ad\u03bd\u03c4\u03b1\u03be\u03b7 \u03c3\u03c4\u03bf\u03bd \u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf \u03b5\u03b9\u03b4\u03b9\u03ba\u03bf\u03c4\u03ae\u03c4\u03c9\u03bd \u03c4\u03bf\u03c5 FOPH- \u03b3\u03b9\u03b1 \u03c4\u03b1 \u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd EMA \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03b1 CAR-T \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03c4\u03b1\u03c1\u03c7\u03ae\u03bd \u03b4\u03c5\u03bd\u03b1\u03c4\u03ae, \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03c9\u03bd \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03c9\u03bd.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Zusammenfassung\"><\/span>\u03a0\u03b5\u03c1\u03af\u03bb\u03b7\u03c8\u03b7<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1<\/th><th>\u0388\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u0395\u0395<\/th><th>\u0395\u03c0\u03b9\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae SHI \u0393\u03b5\u03c1\u03bc\u03b1\u03bd\u03af\u03b1<\/th><\/tr><\/thead><tbody><tr><td>CAR-T (Kymriah, Yescarta, Tecartus, Breyanzi, Abecma, Carvykti)<\/td><td>\u039d\u03b1\u03b9 (EMA)<\/td><td>\u0392\u03b1\u03c3\u03b9\u03ba\u03ac \u03bd\u03b1\u03b9 - \u03b1\u03bb\u03bb\u03ac \u03bc\u03ad\u03c3\u03c9 \u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03ce\u03bd \u03b1\u03b9\u03c4\u03ae\u03c3\u03b5\u03c9\u03bd\/NUB, \u03bc\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b3\u03c1\u03b1\u03c6\u03b5\u03b9\u03bf\u03ba\u03c1\u03b1\u03c4\u03af\u03b1.<\/td><\/tr><tr><td>Kimmtrak (Tebentafusp)<\/td><td>\u039d\u03b1\u03b9 (EMA)<\/td><td>\u039d\u03b1\u03b9 (\u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 AMNOG, \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03ac \u03b9\u03b1\u03c4\u03c1\u03b5\u03af\u03b1)<\/td><\/tr><tr><td>Lifileucel \/ Amtagvi (TIL)<\/td><td>\u038c\u03c7\u03b9 (\u03b7 \u03b1\u03af\u03c4\u03b7\u03c3\u03b7 EMA \u03b1\u03c0\u03bf\u03c3\u03cd\u03c1\u03b8\u03b7\u03ba\u03b5 \u03c4\u03bf\u03bd \u0399\u03bf\u03cd\u03bb\u03b9\u03bf \u03c4\u03bf\u03c5 2025)<\/td><td>\u038c\u03c7\u03b9<\/td><\/tr><tr><td>Afami-cel \/ Tecelra (TCR-T)<\/td><td>\u038c\u03c7\u03b9 (\u03bc\u03cc\u03bd\u03bf FDA)<\/td><td>\u038c\u03c7\u03b9<\/td><\/tr><tr><td>PRAME-TCR (IMA203, \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc)<\/td><td>\u038c\u03c7\u03b9 (\u03a6\u03ac\u03c3\u03b7 3)<\/td><td>\u038c\u03c7\u03b9 - \u03bc\u03cc\u03bd\u03bf \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae\u03c2 \u03c3\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03cc \u03c0\u03bf\u03bb\u03b9\u03c4\u03b9\u03ba\u03cc \u03c0\u03c1\u03cc\u03b2\u03bb\u03b7\u03bc\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9: \u039c\u03ad\u03c7\u03c1\u03b9 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1, \u03b4\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03ad\u03bd\u03b1 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03bb\u03cc \u03bd\u03bf\u03bc\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03c7\u03c1\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03bf\u03c4\u03b9\u03ba\u03cc \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c4\u03b1\u03c7\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03be\u03b9\u03cc\u03c0\u03b9\u03c3\u03c4\u03b7 \u03b1\u03c0\u03b5\u03b9\u03ba\u03cc\u03bd\u03b9\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ce\u03bd \u03c4\u03c9\u03bd \u03ba\u03b1\u03b9\u03bd\u03bf\u03c4\u03cc\u03bc\u03c9\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03b9\u03ce\u03bd \u03c3\u03c4\u03bf \u03b3\u03b5\u03c1\u03bc\u03b1\u03bd\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1. \u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c7\u03c1\u03b5\u03b9\u03b1\u03c3\u03c4\u03bf\u03cd\u03bd \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03bc\u03ad\u03c7\u03c1\u03b9 \u03c4\u03bf \u03ba\u03cc\u03c3\u03c4\u03bf\u03c2 \u03bc\u03b9\u03b1\u03c2 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b1\u03b9\u03bd\u03bf\u03c4\u03bf\u03bc\u03af\u03b1\u03c2 \u03bd\u03b1 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c4\u03bf\u03c0\u03c4\u03c1\u03b9\u03c3\u03c4\u03b5\u03af \u03c3\u03c9\u03c3\u03c4\u03ac \u03c3\u03c4\u03bf \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03ba\u03b1\u03c4' \u03b1\u03c0\u03bf\u03ba\u03bf\u03c0\u03ae\u03bd \u03b1\u03bd\u03ac \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7.<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"PKV_und_Immunzelltherapie_%E2%80%93_Die_vollstandige_Rechtslage\"><\/span>PKV \u03ba\u03b1\u03b9 \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 - \u03b7 \u03c0\u03bb\u03ae\u03c1\u03b7\u03c2 \u03bd\u03bf\u03bc\u03b9\u03ba\u03ae \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u039a\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7: \u03a6\u03b5\u03b2\u03c1\u03bf\u03c5\u03ac\u03c1\u03b9\u03bf\u03c2 2026<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Das_rechtliche_Fundament_%C2%A7_192_VVG_und_MBKK_2009\"><\/span>\u0397 \u03bd\u03bf\u03bc\u03b9\u03ba\u03ae \u03b2\u03ac\u03c3\u03b7: \u00a7 192 VVG \u03ba\u03b1\u03b9 MB\/KK 2009<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b9\u03c3\u03b7\u03c2 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ce\u03bd \u03b5\u03be\u03cc\u03b4\u03c9\u03bd, \u03bf \u03b1\u03c3\u03c6\u03b1\u03bb\u03b9\u03c3\u03c4\u03ae\u03c2 \u03c5\u03c0\u03bf\u03c7\u03c1\u03b5\u03bf\u03cd\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03b6\u03b7\u03bc\u03b9\u03ce\u03c3\u03b5\u03b9 \u03c4\u03b1 \u03ad\u03be\u03bf\u03b4\u03b1 \u03b3\u03b9\u03b1 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ac \u03b1\u03bd\u03b1\u03b3\u03ba\u03b1\u03af\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bb\u03cc\u03b3\u03c9 \u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2 \u03ae \u03c4\u03c9\u03bd \u03c3\u03c5\u03bd\u03b5\u03c0\u03b5\u03b9\u03ce\u03bd \u03b1\u03c4\u03c5\u03c7\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c3\u03c4\u03bf \u03b2\u03b1\u03b8\u03bc\u03cc \u03c0\u03bf\u03c5 \u03ad\u03c7\u03b5\u03b9 \u03c3\u03c5\u03bc\u03c6\u03c9\u03bd\u03b7\u03b8\u03b5\u03af. \u039f \u03b1\u03c3\u03c6\u03b1\u03bb\u03b9\u03c3\u03c4\u03ae\u03c2 \u03b4\u03b5\u03bd \u03c5\u03c0\u03bf\u03c7\u03c1\u03b5\u03bf\u03cd\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03b2\u03ac\u03bb\u03b5\u03b9 \u03c0\u03b1\u03c1\u03bf\u03c7\u03ad\u03c2 \u03b5\u03ac\u03bd \u03c4\u03b1 \u03ad\u03be\u03bf\u03b4\u03b1 \u03b3\u03b9\u03b1 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03c0\u03b5\u03c1\u03af\u03b8\u03b1\u03bb\u03c8\u03b7 \u03ae \u03ac\u03bb\u03bb\u03b5\u03c2 \u03c0\u03b1\u03c1\u03bf\u03c7\u03ad\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03bc\u03c6\u03b1\u03bd\u03ce\u03c2 \u03b4\u03c5\u03c3\u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b9\u03c2 \u03c0\u03b1\u03c1\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 \u03c0\u03b1\u03c1\u03bf\u03c7\u03ad\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039d\u03bf\u03bc\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c4\u03cd\u03c0\u03c9\u03c3\u03b7 \u00a7 192 VVG (\u03c0\u03bb\u03ae\u03c1\u03b7\u03c2):<\/strong> <a href=\"https:\/\/dejure.org\/gesetze\/VVG\/192.html\" target=\"_blank\" rel=\"noopener\">dejure.org - \u03a4\u03bc\u03ae\u03bc\u03b1 192 VVG \u03a4\u03c5\u03c0\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03c1\u03bf\u03c7\u03ad\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03c3\u03c6\u03b1\u03bb\u03b9\u03c3\u03c4\u03ae<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0395\u03c0\u03af\u03c3\u03b7\u03bc\u03b5\u03c2 \u03c3\u03c5\u03bd\u03b8\u03ae\u03ba\u03b5\u03c2 \u03b4\u03b5\u03b9\u03b3\u03bc\u03b1\u03c4\u03bf\u03bb\u03b7\u03c8\u03af\u03b1\u03c2 MB\/KK 2009 (PDF, PKV-Verband):<\/strong> <a href=\"https:\/\/www.pkv.de\/fileadmin\/user_upload\/PKV\/3_PDFs\/ABV_und_MB\/MB-KK.pdf\" target=\"_blank\" rel=\"noopener\">pkv.de - MB\/KK 2009 \u03b4\u03b5\u03b9\u03b3\u03bc\u03b1\u03c4\u03bf\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03bf\u03af \u03cc\u03c1\u03bf\u03b9<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039f\u03b9 \u03c5\u03c0\u03bf\u03c7\u03c1\u03b5\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03c9\u03bd \u03b9\u03b4\u03b9\u03c9\u03c4\u03b9\u03ba\u03ce\u03bd \u03b1\u03c3\u03c6\u03b1\u03bb\u03b9\u03c3\u03c4\u03ce\u03bd \u03c5\u03b3\u03b5\u03af\u03b1\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03bf\u03c7\u03ae \u03c0\u03b1\u03c1\u03bf\u03c7\u03ce\u03bd \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03cc \u03c4\u03bf \u03c4\u03b9\u03bc\u03bf\u03bb\u03cc\u03b3\u03b9\u03bf \u03c0\u03bf\u03c5 \u03b5\u03c0\u03b9\u03bb\u03ad\u03b3\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03cc\u03c1\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5 \u03c4\u03b9\u03bc\u03bf\u03bb\u03bf\u03b3\u03af\u03bf\u03c5. \u03a3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03ac\u03c1\u03b8\u03c1\u03bf 192 \u03c0\u03b1\u03c1. 1 VVG \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 \u03c4\u03bf\u03bd MB\/KK, \u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03ad\u03c6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b1 \u03ad\u03be\u03bf\u03b4\u03b1 \u03b3\u03b9\u03b1 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ac \u03b1\u03bd\u03b1\u03b3\u03ba\u03b1\u03af\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bb\u03cc\u03b3\u03c9 \u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2 \u03ae \u03c4\u03c9\u03bd \u03c3\u03c5\u03bd\u03b5\u03c0\u03b5\u03b9\u03ce\u03bd \u03b1\u03c4\u03c5\u03c7\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0395\u03c0\u03b5\u03be\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c5\u03c0\u03bf\u03c7\u03c1\u03ad\u03c9\u03c3\u03b7\u03c2 \u03c0\u03b1\u03c1\u03bf\u03c7\u03ce\u03bd PKV \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03ac\u03c1\u03b8\u03c1\u03bf 192 VVG:<\/strong> <a href=\"https:\/\/www.legal-plus.eu\/die-leistungspflicht-der-privaten-krankenversicherung-pkv-wann-und-wofuer-muss-die-pkv-zahlen\/\" target=\"_blank\" rel=\"noopener\">legal-plus.eu - \u0397 \u03c5\u03c0\u03bf\u03c7\u03c1\u03ad\u03c9\u03c3\u03b7 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ae\u03c2 \u03c4\u03bf\u03c5 PKV: \u03a0\u03cc\u03c4\u03b5 \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c0\u03bf\u03b9\u03bf \u03bb\u03cc\u03b3\u03bf \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c0\u03bb\u03b7\u03c1\u03ce\u03c3\u03b5\u03b9 \u03bf PKV;<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Der_Schlusselbegriff_%E2%80%9EMedizinisch_notwendige_Heilbehandlung%E2%80%9C\"><\/span>\u039f \u03cc\u03c1\u03bf\u03c2 \u03ba\u03bb\u03b5\u03b9\u03b4\u03af: \u201e\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ac \u03b1\u03bd\u03b1\u03b3\u03ba\u03b1\u03af\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u201c<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03ac\u03b3\u03b9\u03b1 \u03bd\u03bf\u03bc\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03bf\u03c5\u03c2 \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03bf\u03c5\u03c2 \u03cc\u03c1\u03bf\u03c5\u03c2 MB\/KK \u03ba\u03b1\u03b9 \u03c4\u03bf \u03ac\u03c1\u03b8\u03c1\u03bf 192 VVG, \u03b7 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03b3\u03ba\u03b1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c5\u03c6\u03af\u03c3\u03c4\u03b1\u03c4\u03b1\u03b9 \u03b5\u03ac\u03bd \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03b7, \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b5\u03b9\u03bc\u03b5\u03bd\u03b9\u03ba\u03ac \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ac \u03c0\u03bf\u03c1\u03af\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03b3\u03bd\u03ce\u03c3\u03b5\u03b9\u03c2, \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03b3\u03bd\u03ce\u03c1\u03b9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b9\u03b1\u03c2 \u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2, \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03b4\u03b5\u03af\u03bd\u03c9\u03c3\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03ae \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03ba\u03bf\u03cd\u03c6\u03b9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd. \u039a\u03b1\u03b8\u03bf\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03ac\u03bd, \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b3\u03bd\u03ce\u03bc\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03c1\u03bc\u03cc\u03b4\u03b9\u03bf\u03c5 \u03b9\u03b1\u03c4\u03c1\u03bf\u03cd \u03ba\u03b1\u03c4\u03ac \u03c4\u03bf \u03c7\u03c1\u03cc\u03bd\u03bf \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2, \u03c4\u03bf \u03bc\u03ad\u03c4\u03c1\u03bf \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03bd\u03b1\u03b3\u03ba\u03b1\u03af\u03bf \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03b1 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ac \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03b1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039d\u03bf\u03bc\u03b9\u03ba\u03ae \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7: \u039f\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c4\u03b7\u03c2 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03b1\u03b3\u03ba\u03b1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b9\u03b4\u03b9\u03c9\u03c4\u03b9\u03ba\u03ae \u03b1\u03c3\u03c6\u03ac\u03bb\u03b9\u03c3\u03b7 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2:<\/strong> <a href=\"https:\/\/kanzlei-neue-kraeme.de\/erstattung-kostenintensiver-behandlungsmassnahmen-in-der-pkv\/\" target=\"_blank\" rel=\"noopener\">kanzlei-neue-kraeme.de - \u0391\u03c0\u03bf\u03b6\u03b7\u03bc\u03af\u03c9\u03c3\u03b7 \u03bc\u03ad\u03c4\u03c1\u03c9\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03ad\u03bd\u03c4\u03b1\u03c3\u03b7\u03c2 \u03ba\u03cc\u03c3\u03c4\u03bf\u03c5\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b9\u03b4\u03b9\u03c9\u03c4\u03b9\u03ba\u03ae \u03b1\u03c3\u03c6\u03ac\u03bb\u03b9\u03c3\u03b7 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0395\u03ba\u03c4\u03cc\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03b9\u03ba\u03ae \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae, \u03b7 \u03b9\u03b4\u03b9\u03c9\u03c4\u03b9\u03ba\u03ae \u03b1\u03c3\u03c6\u03ac\u03bb\u03b9\u03c3\u03b7 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2 \u03b1\u03c0\u03bf\u03b6\u03b7\u03bc\u03b9\u03ce\u03bd\u03b5\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03c7\u03b8\u03b5\u03af \u03b5\u03be\u03af\u03c3\u03bf\u03c5 \u03c5\u03c0\u03bf\u03c3\u03c7\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ac\u03be\u03b7 \u03ae \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03b4\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03bb\u03cd\u03c3\u03b7. \u0391\u03c5\u03c4\u03ad\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03ad\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03ae \u03ba\u03b1\u03b9\u03bd\u03bf\u03c4\u03cc\u03bc\u03b5\u03c2 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9 \u03c0\u03bf\u03c5 \u03b8\u03b5\u03c9\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03b5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03b5\u03b9\u03b4\u03b9\u03ba\u03bf\u03cd\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a3\u03cd\u03bd\u03b4\u03b5\u03c3\u03bc\u03bf\u03c2 PKV: \u0395\u03c0\u03af\u03c3\u03b7\u03bc\u03b7 \u03b5\u03c0\u03b5\u03be\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c0\u03b1\u03c1\u03bf\u03c7\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03b6\u03b7\u03bc\u03af\u03c9\u03c3\u03b7\u03c2 (\u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd \u03c4\u03c9\u03bd \u03ba\u03b1\u03b9\u03bd\u03bf\u03c4\u03cc\u03bc\u03c9\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03b9\u03ce\u03bd):<\/strong> <a href=\"https:\/\/www.pkv.de\/wissen\/private-krankenversicherung\/leistungen-und-erstattung\/\" target=\"_blank\" rel=\"noopener\">pkv.de - \u03a0\u03b1\u03c1\u03bf\u03c7\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03b6\u03b7\u03bc\u03b9\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b9\u03b4\u03b9\u03c9\u03c4\u03b9\u03ba\u03ae \u03b1\u03c3\u03c6\u03ac\u03bb\u03b9\u03c3\u03b7 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Das_Richtungsurteil_OLG_Frankfurt_29062022_%E2%80%93_Az_7_U_14021\"><\/span>\u0397 \u03b1\u03c0\u03cc\u03c6\u03b1\u03c3\u03b7-\u03bf\u03c1\u03cc\u03c3\u03b7\u03bc\u03bf: OLG \u03a6\u03c1\u03b1\u03bd\u03ba\u03c6\u03bf\u03cd\u03c1\u03c4\u03b7\u03c2, 29.06.2022 - Ref. 7 U 140\/21<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u0391\u03c5\u03c4\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ae \u03ba\u03c1\u03af\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03b6\u03b7\u03bc\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b9\u03b4\u03b9\u03c9\u03c4\u03b9\u03ba\u03ce\u03bd \u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03c3\u03b5\u03c9\u03bd \u03c5\u03b3\u03b5\u03af\u03b1\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03bc\u03b5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c3\u03c4\u03b7 \u0393\u03b5\u03c1\u03bc\u03b1\u03bd\u03af\u03b1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 \u03c5\u03c0\u03cc\u03b8\u03b5\u03c3\u03b7\u03c2<\/strong><br>\u0388\u03bd\u03b1\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03b5\u03af\u03c7\u03b5 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b5\u03af \u03bc\u03b5 \u03bc\u03b7 \u03c7\u03b5\u03b9\u03c1\u03bf\u03c5\u03c1\u03b3\u03ae\u03c3\u03b9\u03bc\u03bf \u03cc\u03b3\u03ba\u03bf \u03c3\u03c4\u03bf \u03c0\u03ac\u03b3\u03ba\u03c1\u03b5\u03b1\u03c2. \u039c\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c4\u03c5\u03c7\u03af\u03b1 \u03c4\u03b7\u03c2 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2, \u03b1\u03c0\u03bf\u03c6\u03ac\u03c3\u03b9\u03c3\u03b5 \u03bd\u03b1 \u03bc\u03b7\u03bd \u03b5\u03c6\u03b1\u03c1\u03bc\u03cc\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ba\u03b1\u03b8\u03b9\u03b5\u03c1\u03c9\u03bc\u03ad\u03bd\u03b7 \u03c0\u03b1\u03c1\u03b7\u03b3\u03bf\u03c1\u03b7\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c0\u03c1\u03bf\u03c3\u03ad\u03c6\u03b5\u03c1\u03b5 \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c0\u03c1\u03cc\u03b3\u03bd\u03c9\u03c3\u03b7 \u03b5\u03c0\u03b9\u03c4\u03c5\u03c7\u03af\u03b1\u03c2, \u03ba\u03b1\u03b9 \u03b1\u03bd\u03c4' \u03b1\u03c5\u03c4\u03bf\u03cd \u03b5\u03c0\u03ad\u03bb\u03b5\u03be\u03b5 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03b4\u03b5\u03bd\u03b4\u03c1\u03b9\u03c4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1. \u0389\u03b8\u03b5\u03bb\u03b5 \u03bd\u03b1 \u03b4\u03b9\u03b5\u03ba\u03b4\u03b9\u03ba\u03ae\u03c3\u03b5\u03b9 \u03c4\u03bf \u03ba\u03cc\u03c3\u03c4\u03bf\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b9\u03b4\u03b9\u03c9\u03c4\u03b9\u03ba\u03ae \u03c4\u03bf\u03c5 \u03b1\u03c3\u03c6\u03b1\u03bb\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b5\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b1 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2 - \u03b1\u03bb\u03bb\u03ac \u03b1\u03c5\u03c4\u03ae \u03b1\u03c1\u03bd\u03ae\u03b8\u03b7\u03ba\u03b5 \u03bd\u03b1 \u03c0\u03bb\u03b7\u03c1\u03ce\u03c3\u03b5\u03b9 \u03c4\u03bf \u03c3\u03cd\u03bd\u03bf\u03bb\u03bf \u03c4\u03c9\u03bd \u03b5\u03be\u03cc\u03b4\u03c9\u03bd.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039a\u03c1\u03af\u03c3\u03b7<\/strong><br>\u0397 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03b4\u03b5\u03bd\u03b4\u03c1\u03b9\u03c4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03ad\u03bd\u03bd\u03bf\u03b9\u03b1 \u03c4\u03c9\u03bd \u03cc\u03c1\u03c9\u03bd \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03bf\u03cd \u03ba\u03cc\u03c3\u03c4\u03bf\u03c5\u03c2 (MB\/KK 2009) \u03c4\u03c9\u03bd \u03b9\u03b4\u03b9\u03c9\u03c4\u03b9\u03ba\u03ce\u03bd \u03b5\u03c4\u03b1\u03b9\u03c1\u03b5\u03b9\u03ce\u03bd \u03b1\u03c3\u03c6\u03ac\u03bb\u03b9\u03c3\u03b7\u03c2 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2. \u0395\u03ac\u03bd \u03bc\u03b9\u03b1 \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c0\u03c1\u03ce\u03c4\u03b7\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae\u03c2 \u03b4\u03b5\u03bd \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b8\u03c5\u03bc\u03b7\u03c4\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03c4\u03c5\u03c7\u03af\u03b1 \u03b3\u03b9\u03b1 \u03ad\u03bd\u03b1 \u03ac\u03c4\u03bf\u03bc\u03bf \u03c0\u03bf\u03c5 \u03c0\u03ac\u03c3\u03c7\u03b5\u03b9 \u03b1\u03c0\u03cc \u03cc\u03b3\u03ba\u03bf \u03c0\u03bf\u03c5 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03ad\u03c6\u03b5\u03b9 \u03c4\u03b7 \u03b6\u03c9\u03ae \u03c4\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03af\u03b1\u03c4\u03bf\u03c2, \u03bf \u03b1\u03c3\u03c6\u03b1\u03bb\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c2 \u03b4\u03b5\u03bd \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c0\u03b5\u03bc\u03c6\u03b8\u03b5\u03af \u03c3\u03b5 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03b7\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae\u03c2 \u03bc\u03b5 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c0\u03c1\u03cc\u03b3\u03bd\u03c9\u03c3\u03b7 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2. \u0391\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b6\u03b7\u03c4\u03ae\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ac\u03bc\u03b5\u03c3\u03b7 \u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03ae \u03c4\u03bf\u03c5 \u03ba\u03cc\u03c3\u03c4\u03bf\u03c5\u03c2 \u03bc\u03b9\u03b1\u03c2 \u03bd\u03ad\u03b1\u03c2, \u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ac \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2, \u03b5\u03ac\u03bd, \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03c3\u03c4\u03b9\u03b3\u03bc\u03ae \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2, \u03b1\u03c5\u03c4\u03ae \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03cc\u03c7\u03b9 \u03b5\u03bd\u03c4\u03b5\u03bb\u03ce\u03c2 \u03b1\u03c0\u03bf\u03bc\u03b1\u03ba\u03c1\u03c5\u03c3\u03bc\u03ad\u03bd\u03b7 \u03c0\u03c1\u03bf\u03bf\u03c0\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03c4\u03c5\u03c7\u03af\u03b1\u03c2 \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03c5\u03bd\u03ae\u03b8\u03b7 \u03c0\u03b1\u03c1\u03b7\u03b3\u03bf\u03c1\u03b7\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a0\u03bb\u03ae\u03c1\u03b7\u03c2 \u03c3\u03c5\u03b6\u03ae\u03c4\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03cc\u03c6\u03b1\u03c3\u03b7\u03c2 (DATEV Magazin):<\/strong> <a href=\"https:\/\/www.datev-magazin.de\/nachrichten-steuern-recht\/recht\/private-krankenversicherung-muss-bei-inoperablem-tumor-nach-gescheiterter-chemotherapie-kosten-einer-alternativtherapie-mit-dendritischen-zellen-tragen-81762\" target=\"_blank\" rel=\"noopener\">datev-magazin.de - OLG \u03a6\u03c1\u03b1\u03bd\u03ba\u03c6\u03bf\u03cd\u03c1\u03c4\u03b7\u03c2: \u0397 PKV \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03bd\u03b1\u03bb\u03ac\u03b2\u03b5\u03b9 \u03c4\u03bf \u03ba\u03cc\u03c3\u03c4\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03bc\u03b5 \u03b4\u03b5\u03bd\u03b4\u03c1\u03b9\u03c4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0395\u03c0\u03b1\u03bd\u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03cc\u03c6\u03b1\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03bf\u03bc\u03b9\u03ba\u03ae\u03c2 \u03b9\u03c3\u03c7\u03cd\u03bf\u03c2 (\u0399\u03b1\u03bd\u03bf\u03c5\u03ac\u03c1\u03b9\u03bf\u03c2 2023):<\/strong> <a href=\"https:\/\/transkript.de\/artikel\/2023\/krankenkasse-muss-zelltherapie-zahlen\/\" target=\"_blank\" rel=\"noopener\">transkript.de - \u0397 \u03b1\u03c3\u03c6\u03b1\u03bb\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b5\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b1 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c0\u03bb\u03b7\u03c1\u03ce\u03bd\u03b5\u03b9 \u03b3\u03b9\u03b1 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 (\u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03af\u03c9\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03bd\u03bf\u03bc\u03b9\u03ba\u03ae\u03c2 \u03b9\u03c3\u03c7\u03cd\u03bf\u03c2)<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0391\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03ba\u03c1\u03af\u03c3\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03bd\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03b1 (IWW Verg\u00fctungsrecht):<\/strong> <a href=\"https:\/\/www.iww.de\/cb\/recht\/verguetungsrecht-schulmedizinische-behandlung-erfolglos-pkvmuss-kosten-der-alternativtherapie-tragen-f149155\" target=\"_blank\" rel=\"noopener\">iww.de - \u0397 PKV \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03bd\u03b1\u03bb\u03ac\u03b2\u03b5\u03b9 \u03c4\u03bf \u03ba\u03cc\u03c3\u03c4\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Haufe: \u03a3\u03cd\u03bd\u03c4\u03bf\u03bc\u03b7 \u03c0\u03b5\u03c1\u03af\u03bb\u03b7\u03c8\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03cc\u03c6\u03b1\u03c3\u03b7\u03c2:<\/strong> <a href=\"https:\/\/www.haufe.de\/recht\/weitere-rechtsgebiete\/inoperabler-tumor-uebernahme-von-alternativtherapie-durch-pkv_216_571650.html\" target=\"_blank\" rel=\"noopener\">haufe.de - \u0391\u03bd\u03b5\u03b3\u03c7\u03b5\u03af\u03c1\u03b7\u03c4\u03bf\u03c2 \u03cc\u03b3\u03ba\u03bf\u03c2: \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c0\u03bf\u03c5 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd PKV<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039b\u03b5\u03c0\u03c4\u03bf\u03bc\u03b5\u03c1\u03ae\u03c2 \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03c1\u03af\u03c3\u03b7\u03c2 (J\u00f6hnke &amp; Reichow Rechtsanw\u00e4lte):<\/strong> <a href=\"https:\/\/joehnke-reichow.de\/2024\/07\/17\/kostenerstattung-bei-einer-dendritischen-zellbehandlung-olg-frankfurt\/\" target=\"_blank\" rel=\"noopener\">joehnke-reichow.de - \u0395\u03c0\u03b9\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae \u03b4\u03b1\u03c0\u03b1\u03bd\u03ce\u03bd \u03b3\u03b9\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03b4\u03b5\u03bd\u03b4\u03c1\u03b9\u03c4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, OLG Frankfurt<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039d\u03bf\u03bc\u03b9\u03ba\u03ae \u03b9\u03c3\u03c7\u03cd\u03c2:<\/strong> \u03a3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03bf \u0391\u03bd\u03ce\u03c4\u03b1\u03c4\u03bf \u03a0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b5\u03b9\u03b1\u03ba\u03cc \u0394\u03b9\u03ba\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf \u03c4\u03b7\u03c2 \u0388\u03c3\u03c3\u03b7\u03c2, \u03b7 \u03c0\u03c1\u03bf\u03b8\u03b5\u03c3\u03bc\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03ac\u03c3\u03ba\u03b7\u03c3\u03b7 \u03ad\u03c6\u03b5\u03c3\u03b7\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03bb\u03ae\u03be\u03b5\u03b9, \u03c0\u03c1\u03ac\u03b3\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03b1\u03c0\u03cc\u03c6\u03b1\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03bf\u03bc\u03b9\u03ba\u03ac \u03b4\u03b5\u03c3\u03bc\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u0399\u03b1\u03bd\u03bf\u03c5\u03ac\u03c1\u03b9\u03bf \u03c4\u03bf\u03c5 2023.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Das_%E2%80%9Eauffallige_Missverhaltnis%E2%80%9C_nach_%C2%A7_192_Abs_2_VVG_%E2%80%93_und_warum_es_bei_CAR-T_nicht_greift\"><\/span>\u0397 \u201e\u03b5\u03bc\u03c6\u03b1\u03bd\u03ae\u03c2 \u03b4\u03c5\u03c3\u03b1\u03bd\u03b1\u03bb\u03bf\u03b3\u03af\u03b1\u201c \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03ac\u03c1\u03b8\u03c1\u03bf 192 \u03c0\u03b1\u03c1\u03ac\u03b3\u03c1\u03b1\u03c6\u03bf\u03c2 2 VVG - \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1\u03c4\u03af \u03b4\u03b5\u03bd \u03b9\u03c3\u03c7\u03cd\u03b5\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd CAR-T<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf \u03b2\u03ac\u03c1\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03cc\u03b4\u03b5\u03b9\u03be\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03cd\u03c0\u03b1\u03c1\u03be\u03b7\u03c2 \u03b5\u03bc\u03c6\u03b1\u03bd\u03bf\u03cd\u03c2 \u03b4\u03c5\u03c3\u03b1\u03bd\u03b1\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 \u03c6\u03ad\u03c1\u03b5\u03b9 \u03bf \u03b1\u03c3\u03c6\u03b1\u03bb\u03b9\u03c3\u03c4\u03ae\u03c2. \u03a5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c3\u03c5\u03bc\u03c6\u03c9\u03bd\u03af\u03b1 \u03cc\u03c4\u03b9 \u03b7 \u03c3\u03c5\u03bd\u03ae\u03b8\u03b7\u03c2 \u03b1\u03be\u03af\u03b1 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c1\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03b7\u03c2 \u03c5\u03c0\u03b7\u03c1\u03b5\u03c3\u03af\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03b8\u03bf\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03b7 \u03c4\u03b9\u03bc\u03ae \u03b3\u03b9\u03b1 \u03c4\u03bf \u03b5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03bf \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03cc \u03ba\u03cc\u03c3\u03c4\u03bf\u03c2. \u0395\u03c6\u03b1\u03c1\u03bc\u03cc\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7 \u03bd\u03bf\u03bc\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 \u039f\u03bc\u03bf\u03c3\u03c0\u03bf\u03bd\u03b4\u03b9\u03b1\u03ba\u03bf\u03cd \u0394\u03b9\u03ba\u03b1\u03c3\u03c4\u03b7\u03c1\u03af\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b1 \u03b1\u03b4\u03b9\u03ba\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c4\u03bf\u03ba\u03bf\u03b3\u03bb\u03c5\u03c6\u03af\u03b1\u03c2, \u03b7 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03b3\u03bf\u03c1\u03ac\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03bf \u03bc\u03ad\u03c3\u03bf \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03c0\u03c1\u03bf\u03c3\u03b4\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03cc \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b5\u03b9\u03bc\u03b5\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b1\u03be\u03af\u03b1\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0394\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03bf\u03c5 \u03cc\u03c4\u03b9 \u03bf\u03b9 CAR-T \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03c4\u03b9\u03bc\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c3\u03c5\u03b3\u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03bf \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 (250.000-600.000 \u03b5\u03c5\u03c1\u03ce), \u03bc\u03b9\u03b1 \u201e\u03b5\u03bc\u03c6\u03b1\u03bd\u03ae\u03c2 \u03b1\u03bd\u03b9\u03c3\u03bf\u03c1\u03c1\u03bf\u03c0\u03af\u03b1\u201c \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03ba\u03c5\u03c1\u03c9\u03b8\u03b5\u03af \u03b1\u03c0\u03cc \u03bc\u03b9\u03b1 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03b5\u03b8\u03bd\u03bf\u03cd\u03c2 \u03b1\u03b3\u03bf\u03c1\u03ac\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039d\u03bf\u03bc\u03b9\u03ba\u03ae \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u201e\u03b5\u03bc\u03c6\u03b1\u03bd\u03bf\u03cd\u03c2 \u03b4\u03c5\u03c3\u03b1\u03bd\u03b1\u03bb\u03bf\u03b3\u03af\u03b1\u03c2\u201c \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03ac\u03c1\u03b8\u03c1\u03bf 192 \u03c0\u03b1\u03c1\u03ac\u03b3\u03c1\u03b1\u03c6\u03bf\u03c2 2 VVG:<\/strong> <a href=\"https:\/\/www.kunzrechtsanwaelte.de\/aktuelles\/urteile\/versicherung-und-haftung\/krankenversicherung\" target=\"_blank\" rel=\"noopener\">kunzrechtsanwaelte.de - \u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03b1\u03bd\u03ae \u03b4\u03c5\u03c3\u03b1\u03bd\u03b1\u03bb\u03bf\u03b3\u03af\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03ad\u03bd\u03bd\u03bf\u03b9\u03b1 \u03c4\u03bf\u03c5 \u00a7 192 \u03c0\u03b1\u03c1. 2 VVG<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Das_Voranfrageverfahren_nach_%C2%A7_192_Abs_8_VVG_%E2%80%93_der_wichtigste_praktische_Schritt\"><\/span>\u0397 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03c4\u03b1\u03c1\u03ba\u03c4\u03b9\u03ba\u03ae\u03c2 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1\u03c2 \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03ac\u03c1\u03b8\u03c1\u03bf 192 \u03c0\u03b1\u03c1\u03ac\u03b3\u03c1\u03b1\u03c6\u03bf\u03c2 8 VVG - \u03c4\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03bf \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03cc \u03b2\u03ae\u03bc\u03b1<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u0391\u03c0\u03cc \u03c4\u03b7 \u03c3\u03c4\u03b9\u03b3\u03bc\u03ae \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c8\u03b9\u03bc\u03bf \u03cc\u03c4\u03b9 \u03c4\u03bf \u03b1\u03bd\u03b1\u03bc\u03b5\u03bd\u03cc\u03bc\u03b5\u03bd\u03bf \u03ba\u03cc\u03c3\u03c4\u03bf\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03b8\u03b1 \u03c5\u03c0\u03b5\u03c1\u03b2\u03b5\u03af \u03c4\u03b1 2.000 \u03b5\u03c5\u03c1\u03ce, \u03bf\u03b9 \u03b1\u03c3\u03c6\u03b1\u03bb\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03b9 \u03b4\u03b9\u03ba\u03b1\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7 \u03b4\u03ad\u03c3\u03bc\u03b5\u03c5\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03cc\u03c3\u03c4\u03bf\u03c5\u03c2 \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03ac\u03c1\u03b8\u03c1\u03bf 192 \u03c0\u03b1\u03c1\u03ac\u03b3\u03c1\u03b1\u03c6\u03bf\u03c2 8 VVG. \u0395\u03bd\u03c4\u03cc\u03c2 4 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03c9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c5\u03c0\u03bf\u03b2\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03c0\u03c1\u03cc\u03b2\u03bb\u03b5\u03c8\u03b7\u03c2 \u03ba\u03cc\u03c3\u03c4\u03bf\u03c5\u03c2, \u03b7 \u03b1\u03c3\u03c6\u03b1\u03bb\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b5\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03c3\u03b5\u03b9 \u03ae \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c1\u03c1\u03af\u03c8\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03bb\u03b7\u03c8\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03cc\u03c3\u03c4\u03bf\u03c5\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0395\u03ac\u03bd \u03bf\u03b9 \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b5\u03c2 \u03b4\u03b5\u03bd \u03c0\u03b1\u03c1\u03b1\u03c3\u03c7\u03b5\u03b8\u03bf\u03cd\u03bd \u03b5\u03bd\u03c4\u03cc\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03bf\u03b8\u03b5\u03c3\u03bc\u03af\u03b1\u03c2, \u03bf \u03b1\u03c3\u03c6\u03b1\u03bb\u03b9\u03c3\u03c4\u03ae\u03c2 \u03b8\u03b5\u03c9\u03c1\u03b5\u03af \u03cc\u03c4\u03b9 \u03b7 \u03c0\u03c1\u03bf\u03b2\u03bb\u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03b7 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03c0\u03b5\u03c1\u03af\u03b8\u03b1\u03bb\u03c8\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03b1\u03b3\u03ba\u03b1\u03af\u03b1 \u03bc\u03ad\u03c7\u03c1\u03b9\u03c2 \u03cc\u03c4\u03bf\u03c5 \u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03c7\u03b8\u03b5\u03af \u03c4\u03bf \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03bf. \u0391\u03c5\u03c4\u03cc <strong>\u039c\u03c5\u03b8\u03bf\u03c0\u03bb\u03b1\u03c3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7\u03c2<\/strong> \u03c3\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03bc\u03b7 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03bc\u03ad\u03c3\u03bf \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c3\u03af\u03b1\u03c2 \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0394\u03b9\u03b1\u03c4\u03cd\u03c0\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bd\u03cc\u03bc\u03bf\u03c5 \u00a7 192 \u03c0\u03b1\u03c1. 8 VVG (\u03c5\u03c0\u03bf\u03c7\u03c1\u03ad\u03c9\u03c3\u03b7 \u03b5\u03ba \u03c4\u03c9\u03bd \u03c0\u03c1\u03bf\u03c4\u03ad\u03c1\u03c9\u03bd \u03b5\u03c1\u03ce\u03c4\u03b7\u03c3\u03b7\u03c2):<\/strong> <a href=\"https:\/\/dejure.org\/gesetze\/VVG\/192.html\" target=\"_blank\" rel=\"noopener\">dejure.org - \u0386\u03c1\u03b8\u03c1\u03bf 192 (8) VVG<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2: \u03a0\u03c1\u03bf\u03ba\u03b1\u03c4\u03b1\u03c1\u03ba\u03c4\u03b9\u03ba\u03ae \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03bf PKV \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b5\u03bd\u03c4\u03b1\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1:<\/strong> <a href=\"https:\/\/www.pkv-inhalte.de\/pkv-bu-av-blog\/pkv-versichert-und-teure-behandlung-steht-bevor-wie-geht-man-richtig-vor\/\" target=\"_blank\" rel=\"noopener\">pkv-inhalte.de - \u0391\u03c3\u03c6\u03ac\u03bb\u03b9\u03c3\u03b7 PKV \u03ba\u03b1\u03b9 \u03b1\u03ba\u03c1\u03b9\u03b2\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1: \u03a0\u03bf\u03b9\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c3\u03c9\u03c3\u03c4\u03ae \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7;<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039d\u03bf\u03bc\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c5\u03bd\u03ad\u03c0\u03b5\u03b9\u03b5\u03c2 \u03b5\u03c3\u03c6\u03b1\u03bb\u03bc\u03ad\u03bd\u03c9\u03bd \u03ae \u03b5\u03bb\u03bb\u03b9\u03c0\u03ce\u03bd \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03b9\u03ce\u03bd PKV:<\/strong> <a href=\"https:\/\/www.versicherungsrechtsiegen.de\/krankenhauskosten-zusatzversicherung-kostenerstattung-fuer-aufenthalt-in-privatklinik\/\" target=\"_blank\" rel=\"noopener\">versicherungsrechtsiegen.de - \u0394\u03ad\u03c3\u03bc\u03b5\u03c5\u03c3\u03b7 \u03ba\u03cc\u03c3\u03c4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u00a7 192 \u03c0\u03b1\u03c1. 8 VVG \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ac\u03be\u03b7<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Bei_Ablehnung_Rechtsmittel_und_Klage\"><\/span>\u03a3\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03b1\u03c0\u03cc\u03c1\u03c1\u03b9\u03c8\u03b7\u03c2: \u03c0\u03c1\u03bf\u03c3\u03c6\u03c5\u03b3\u03ae \u03ba\u03b1\u03b9 \u03bd\u03bf\u03bc\u03b9\u03ba\u03ad\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf \u03b6\u03ae\u03c4\u03b7\u03bc\u03b1 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae\u03c2 \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ac\u03c1\u03b8\u03c1\u03bf\u03c5 192 VVG, \u03c4\u03c9\u03bd \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03c9\u03bd \u03cc\u03c1\u03c9\u03bd MB\/KK \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03bc\u03ad\u03c1\u03bf\u03c5\u03c2 \u03c4\u03b9\u03bc\u03bf\u03bb\u03bf\u03b3\u03b9\u03b1\u03ba\u03ce\u03bd \u03c1\u03b7\u03c4\u03c1\u03ce\u03bd. \u039f \u03ba\u03b1\u03b8\u03bf\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03bf\u03c0\u03bf\u03b9\u03ae\u03b8\u03b7\u03ba\u03b5 \u03bb\u03cc\u03b3\u03c9 \u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03bd \u03ae\u03c4\u03b1\u03bd \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ac \u03b1\u03bd\u03b1\u03b3\u03ba\u03b1\u03af\u03b1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03b1\u03c0\u03cc\u03c1\u03c1\u03b9\u03c8\u03b7\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf PKV, \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03bf\u03b9 \u03b1\u03ba\u03cc\u03bb\u03bf\u03c5\u03b8\u03b5\u03c2 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0388\u03bd\u03c3\u03c4\u03b1\u03c3\u03b7 \u03bc\u03b5 \u03c0\u03bb\u03ae\u03c1\u03b7 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03cc \u03c6\u03ac\u03ba\u03b5\u03bb\u03bf<\/strong> (\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b3\u03bd\u03c9\u03bc\u03ac\u03c4\u03b5\u03c5\u03c3\u03b7, \u03c0\u03c1\u03c9\u03c4\u03cc\u03ba\u03bf\u03bb\u03bb\u03bf \u03b5\u03c0\u03b9\u03c4\u03c1\u03bf\u03c0\u03ae\u03c2 \u03cc\u03b3\u03ba\u03bf\u03c5, \u03b4\u03b9\u03b5\u03b8\u03bd\u03ae\u03c2 \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2, \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03ba\u03cc\u03c3\u03c4\u03bf\u03c5\u03c2)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0391\u03b3\u03c9\u03b3\u03ae \u03b5\u03bd\u03ce\u03c0\u03b9\u03bf\u03bd \u03c4\u03bf\u03c5 \u03b1\u03c3\u03c4\u03b9\u03ba\u03bf\u03cd \u03b4\u03b9\u03ba\u03b1\u03c3\u03c4\u03b7\u03c1\u03af\u03bf\u03c5<\/strong> (\u03cc\u03c7\u03b9 \u03ba\u03bf\u03b9\u03bd\u03c9\u03bd\u03b9\u03ba\u03cc \u03b4\u03b9\u03ba\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf, \u03b1\u03c5\u03c4\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c5\u03c0\u03bf\u03c7\u03c1\u03b5\u03c9\u03c4\u03b9\u03ba\u03ae \u03b1\u03c3\u03c6\u03ac\u03bb\u03b9\u03c3\u03b7 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2) \u03bc\u03b5 \u03b1\u03af\u03c4\u03b7\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c0\u03c1\u03bf\u03c3\u03c9\u03c1\u03b9\u03bd\u03ae \u03b4\u03b9\u03b1\u03c4\u03b1\u03b3\u03ae \u03c3\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03b5\u03c0\u03b5\u03af\u03b3\u03bf\u03c5\u03c3\u03b1\u03c2 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a0\u03bb\u03ae\u03c1\u03b7\u03c2 \u03bf\u03b4\u03b7\u03b3\u03cc\u03c2: PKV, \u03b1\u03bd\u03c4\u03af\u03c1\u03c1\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03bd\u03bf\u03bc\u03b9\u03ba\u03ad\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2:<\/strong> <a href=\"https:\/\/kanzlei-neue-kraeme.de\/erstattung-kostenintensiver-behandlungsmassnahmen-in-der-pkv\/\" target=\"_blank\" rel=\"noopener\">kanzlei-neue-kraeme.de - \u0391\u03c0\u03bf\u03b6\u03b7\u03bc\u03af\u03c9\u03c3\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03b9\u03ce\u03bd \u03ad\u03bd\u03c4\u03b1\u03c3\u03b7\u03c2 \u03ba\u03cc\u03c3\u03c4\u03bf\u03c5\u03c2 \u03c3\u03c4\u03bf \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf \u03c4\u03b7\u03c2 \u03b9\u03b4\u03b9\u03c9\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b9\u03c3\u03b7\u03c2 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0386\u03c1\u03bd\u03b7\u03c3\u03b7 \u03b9\u03b4\u03b9\u03c9\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b9\u03c3\u03b7\u03c2 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03bf\u03c7\u03ce\u03bd: \u03bd\u03bf\u03bc\u03b9\u03ba\u03ac \u03b2\u03ae\u03bc\u03b1\u03c4\u03b1 \u03bc\u03b5 \u03bc\u03b9\u03b1 \u03bc\u03b1\u03c4\u03b9\u03ac:<\/strong> <a href=\"https:\/\/kva-plus.de\/ablehnung-der-kostenuebernahme-durch-die-pkv-und-beihilfe\/\" target=\"_blank\" rel=\"noopener\">kva-plus.de - \u0391\u03c0\u03cc\u03c1\u03c1\u03b9\u03c8\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03ac\u03bb\u03c5\u03c8\u03b7\u03c2 \u03c4\u03c9\u03bd \u03b4\u03b1\u03c0\u03b1\u03bd\u03ce\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b9\u03b4\u03b9\u03c9\u03c4\u03b9\u03ba\u03ae \u03b1\u03c3\u03c6\u03ac\u03bb\u03b9\u03c3\u03b7 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03ba\u03c1\u03b1\u03c4\u03b9\u03ba\u03ae \u03b5\u03bd\u03af\u03c3\u03c7\u03c5\u03c3\u03b7<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p><span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">\u03a7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2<\/span> <span class=\"rt-time\"> 20<\/span> <span class=\"rt-label rt-postfix\">\u03bb\u03b5\u03c0\u03c4\u03ac<\/span><\/span>Das Immunsystem &#8211; was macht das? Das Immunsystem unterh\u00e4lt eine ganze Armee von Kundschaftern, K\u00e4mpfern (T-Zellen) und Helfern. Sie patrouillieren st\u00e4ndig durch den K\u00f6rper und suchen nach Eindringlingen, wie Bakterien, Viren, aber auch wild gewordene k\u00f6rpereigene Zellen &#8211; Krebszellen. Normalerweise werden solch randalierende Zellen von den W\u00e4chtern des immunsystems schnell entdeckt, abget\u00f6tet, deren \u00dcberreste abtransportiert&hellip;&nbsp;<a href=\"https:\/\/csiag.eu\/el\/blog\/2026\/02\/19\/immunzelltherapie\/\" rel=\"bookmark\">\u03a0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \"<span class=\"screen-reader-text\">\u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[5584,1078,354],"tags":[],"class_list":["post-12789","post","type-post","status-publish","format-standard","hentry","category-krebs","category-medizin","category-medizin-gesundheit"],"modified_by":"Achim Goerner","_links":{"self":[{"href":"https:\/\/csiag.eu\/el\/wp-json\/wp\/v2\/posts\/12789","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csiag.eu\/el\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csiag.eu\/el\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csiag.eu\/el\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csiag.eu\/el\/wp-json\/wp\/v2\/comments?post=12789"}],"version-history":[{"count":0,"href":"https:\/\/csiag.eu\/el\/wp-json\/wp\/v2\/posts\/12789\/revisions"}],"wp:attachment":[{"href":"https:\/\/csiag.eu\/el\/wp-json\/wp\/v2\/media?parent=12789"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csiag.eu\/el\/wp-json\/wp\/v2\/categories?post=12789"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csiag.eu\/el\/wp-json\/wp\/v2\/tags?post=12789"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}