{"id":5951,"date":"2023-12-15T11:56:22","date_gmt":"2023-12-15T11:56:22","guid":{"rendered":"https:\/\/csiag.eu\/?p=5951"},"modified":"2026-02-14T13:18:49","modified_gmt":"2026-02-14T13:18:49","slug":"suspected-prostate-pancreas-ca","status":"publish","type":"post","link":"https:\/\/csiag.eu\/en\/blog\/2023\/12\/15\/verdacht-auf-prostata-pankreas-ca\/","title":{"rendered":"Suspected prostate CA\/pancreas CA?"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_83 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of contents<\/p>\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/csiag.eu\/en\/blog\/2023\/12\/15\/verdacht-auf-prostata-pankreas-ca\/#Sulforaphan\" >Sulforaphane<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/csiag.eu\/en\/blog\/2023\/12\/15\/verdacht-auf-prostata-pankreas-ca\/#Glucoraphanin\" >Glucoraphanin<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/csiag.eu\/en\/blog\/2023\/12\/15\/verdacht-auf-prostata-pankreas-ca\/#Wirkstoffgehalt\" >Active ingredient content<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/csiag.eu\/en\/blog\/2023\/12\/15\/verdacht-auf-prostata-pankreas-ca\/#Ausgewachsene_Brokkolikopfe_%E2%80%93_100g_Frischgewicht\" >Adult broccoli heads - 100g fresh weight<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/csiag.eu\/en\/blog\/2023\/12\/15\/verdacht-auf-prostata-pankreas-ca\/#Brokkolisprossen_3-5_Tage_gekeimt\" >Broccoli sprouts (sprouted for 3-5 days)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/csiag.eu\/en\/blog\/2023\/12\/15\/verdacht-auf-prostata-pankreas-ca\/#Brokkolisamen_ungekeimtroh\" >Broccoli seeds (unsprouted\/raw)<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/csiag.eu\/en\/blog\/2023\/12\/15\/verdacht-auf-prostata-pankreas-ca\/#Verfugbare_Praparate_auf_dem_Markt\" >Preparations available on the market<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/csiag.eu\/en\/blog\/2023\/12\/15\/verdacht-auf-prostata-pankreas-ca\/#Praparate_mit_Glucoraphanin_mit_Myrosinase\" >Preparations with glucoraphanin with myrosinase<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/csiag.eu\/en\/blog\/2023\/12\/15\/verdacht-auf-prostata-pankreas-ca\/#Praparate_mit_Sprossen-PulverGranulat\" >Preparations with sprout powder\/granules<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/csiag.eu\/en\/blog\/2023\/12\/15\/verdacht-auf-prostata-pankreas-ca\/#Praparate_mit_Sprossen-Extrakt\" >Preparations with sprout extract<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/csiag.eu\/en\/blog\/2023\/12\/15\/verdacht-auf-prostata-pankreas-ca\/#Stabilisiertes_Sulforaphan_hochste_Bioverfugbarkeit\" >Stabilized sulforaphane (highest bioavailability)<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/csiag.eu\/en\/blog\/2023\/12\/15\/verdacht-auf-prostata-pankreas-ca\/#Dosierungsempfehlungen\" >Dosage recommendations<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/csiag.eu\/en\/blog\/2023\/12\/15\/verdacht-auf-prostata-pankreas-ca\/#Optimierung_der_Sulforaphan-Bildung\" >Optimization of sulforaphane formation<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/csiag.eu\/en\/blog\/2023\/12\/15\/verdacht-auf-prostata-pankreas-ca\/#Qualitatskriterien\" >Quality criteria<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/csiag.eu\/en\/blog\/2023\/12\/15\/verdacht-auf-prostata-pankreas-ca\/#Darmgesundheit_ist_Voraussetzung\" >Gut health is a prerequisite<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/csiag.eu\/en\/blog\/2023\/12\/15\/verdacht-auf-prostata-pankreas-ca\/#Wirkung\" >Effect<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/csiag.eu\/en\/blog\/2023\/12\/15\/verdacht-auf-prostata-pankreas-ca\/#Studien\" >Studies<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/csiag.eu\/en\/blog\/2023\/12\/15\/verdacht-auf-prostata-pankreas-ca\/#Prostata-CA\" >Prostate CA<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/csiag.eu\/en\/blog\/2023\/12\/15\/verdacht-auf-prostata-pankreas-ca\/#Pankreas-CA\" >Pancreas CA<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Reading time<\/span> <span class=\"rt-time\"> 6<\/span> <span class=\"rt-label rt-postfix\">minutes<\/span><\/span>\n<p>If prostate CA or pancreatic CA (carcinoma) is suspected, a biopsy will either provide the longed-for relief or sobering confirmation of the suspected diagnosis.<\/p>\n\n\n\n<p>But what can you do to prevent it effectively or even, in the early stages, to avoid an operation with significant consequences and stress?<\/p>\n\n\n\n<p>The Heidelberg University Clinic was already addressing this question regarding prostate CA before 2013 as part of its own <a href=\"https:\/\/www.klinikum.uni-heidelberg.de\/chirurgische-klinik-zentrum\/allgemein-viszeral-und-transplantationschirurgie\/forschung\/pankreasforschung\/sektion-pankreaskarzinomforschung\/ag-molekulare-onkochirurgie\/patienteninformationen\" target=\"_blank\" rel=\"noreferrer noopener\">Research<\/a> within this <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4059031\/\" target=\"_blank\" rel=\"noreferrer noopener\">Pilot study evaluating broccoli sprouts in advanced pancreatic cancer (POUDER trial) \u2013 study protocol for a randomized controlled trial<\/a> (as of June 3, 2014) got to the bottom. Other researchers have also addressed this question.<\/p>\n\n\n\n<p>There is now a significant body of evidence to confirm this <a href=\"#Studien_P\" target=\"_blank\" data-type=\"internal\" data-id=\"#Studien_P\" rel=\"noreferrer noopener\">Studies<\/a> resort to this, which turns the initially vague glimmer of hope into a clear and unmistakable light at the end of the tunnel.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>In addition, the i.v. administration of 75g vitamin C (in parallel with chemotherapy) in stage IV pancreatic cancer has been shown to reduce the risk of cancer in this randomized controlled trial. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2213231724003537\" target=\"_blank\" rel=\"noreferrer noopener\">study<\/a> the mortality risk by 54 %.<\/p>\n<\/blockquote>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Sulforaphan\"><\/span>Sulforaphane<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Initially, hope rested on the extract <em>Sulforaphane<\/em> of broccoli seeds. For the first time in 1990 <em>Sulforaphane<\/em> at the <em>Johns Hopkins School of Medicine<\/em> isolated from broccoli in order to investigate its anticarcinogenic effects in more detail.<\/p>\n\n\n\n<p>This effect, which was initially only hoped for, has now been confirmed: <em>Sulforaphane<\/em> can prevent the development of cancer cells and initiate apoptosis, the cell death of cancer cells from different types of cancer.<\/p>\n\n\n\n<p><em>Sulforaphane<\/em> is an isothiocyanate, a mustard oil obtained from enzymatic hydrolysis of the mustard oil glycoside <em>Glucoraphanin<\/em> is obtained.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Glucoraphanin\"><\/span>Glucoraphanin<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Glucoraphanin is the stable precursor (glucosinolate) of sulforaphane. Through the enzyme <em>Myrosinase<\/em> glucoraphanin is converted into the biologically active sulforaphane during chewing, slicing or in the intestine. Unlike sulforaphane, glucoraphanin is heat and storage stable.<\/p>\n\n\n\n<p>The enzyme myrosinase is stable in the range of 30 - 35 \u00b0C, sulforaphane up to 40 \u00b0C and glucoraphanin up to around 100 \u00b0C. Temperatures above this lead to degradation (decomposition) of the active ingredients and thus to a partial or complete loss of effectiveness.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wirkstoffgehalt\"><\/span>Active ingredient content<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>The active ingredient content of different types of broccoli varies, as do growing conditions such as soil, minerals, climate, harvest time and storage conditions. <\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Ausgewachsene_Brokkolikopfe_%E2%80%93_100g_Frischgewicht\"><\/span>Adult broccoli heads - 100g fresh weight<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img decoding=\"async\" width=\"1024\" height=\"428\" src=\"https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-1024x428.png\" alt=\"\" class=\"wp-image-12653\" style=\"aspect-ratio:2.3925506664232246;width:595px;height:auto\" srcset=\"https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-1024x428.png 1024w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-300x125.png 300w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-768x321.png 768w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-1536x642.png 1536w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-18x8.png 18w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image.png 1664w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Brokkolisprossen_3-5_Tage_gekeimt\"><\/span>Broccoli sprouts (sprouted for 3-5 days)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Broccoli sprouts contain 10 to 100 times more glucoraphanin than full-grown broccoli heads:<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img decoding=\"async\" width=\"1024\" height=\"238\" src=\"https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-1-1024x238.png\" alt=\"\" class=\"wp-image-12654\" style=\"aspect-ratio:4.302741750123133;width:593px;height:auto\" srcset=\"https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-1-1024x238.png 1024w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-1-300x70.png 300w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-1-768x179.png 768w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-1-1536x357.png 1536w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-1-18x4.png 18w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-1.png 1668w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Brokkolisamen_ungekeimtroh\"><\/span><strong>Broccoli seeds (unsprouted\/raw)<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img decoding=\"async\" width=\"1024\" height=\"283\" src=\"https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-2-1024x283.png\" alt=\"\" class=\"wp-image-12655\" style=\"aspect-ratio:3.618390169819136;width:585px;height:auto\" srcset=\"https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-2-1024x283.png 1024w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-2-300x83.png 300w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-2-768x212.png 768w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-2-1536x425.png 1536w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-2-18x5.png 18w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-2.png 1670w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Verfugbare_Praparate_auf_dem_Markt\"><\/span><strong>Preparations available on the market<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Praparate_mit_Glucoraphanin_mit_Myrosinase\"><\/span><strong>Preparations with glucoraphanin with myrosinase<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>These preparations contain the stable precursor glucoraphanin and the enzyme myrosinase, so that sulforaphane is only formed \u201eon site\u201c in the body.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img decoding=\"async\" width=\"1024\" height=\"403\" src=\"https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-3-1024x403.png\" alt=\"\" class=\"wp-image-12656\" style=\"aspect-ratio:2.5410122164048867;width:587px;height:auto\" srcset=\"https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-3-1024x403.png 1024w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-3-300x118.png 300w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-3-768x302.png 768w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-3-1536x604.png 1536w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-3-18x7.png 18w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-3.png 1668w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img decoding=\"async\" width=\"1024\" height=\"267\" src=\"https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-4-1024x267.png\" alt=\"\" class=\"wp-image-12657\" style=\"aspect-ratio:3.835223531133387;width:589px;height:auto\" srcset=\"https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-4-1024x267.png 1024w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-4-300x78.png 300w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-4-768x201.png 768w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-4-1536x401.png 1536w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-4-18x5.png 18w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-4.png 1670w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Praparate_mit_Sprossen-PulverGranulat\"><\/span>Preparations with sprout powder\/granules<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img decoding=\"async\" width=\"1024\" height=\"374\" src=\"https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-5-1024x374.png\" alt=\"\" class=\"wp-image-12658\" style=\"aspect-ratio:2.7379857918930215;width:585px;height:auto\" srcset=\"https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-5-1024x374.png 1024w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-5-300x110.png 300w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-5-768x281.png 768w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-5-1536x561.png 1536w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-5-18x7.png 18w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-5.png 1670w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Praparate_mit_Sprossen-Extrakt\"><\/span>Preparations with sprout extract<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img decoding=\"async\" width=\"1024\" height=\"316\" src=\"https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-6-1024x316.png\" alt=\"\" class=\"wp-image-12659\" style=\"aspect-ratio:3.2405564142194745;width:585px;height:auto\" srcset=\"https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-6-1024x316.png 1024w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-6-300x93.png 300w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-6-768x237.png 768w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-6-1536x474.png 1536w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-6-18x6.png 18w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-6.png 1664w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Stabilisiertes_Sulforaphan_hochste_Bioverfugbarkeit\"><\/span>Stabilized sulforaphane (highest bioavailability)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img decoding=\"async\" width=\"1024\" height=\"188\" src=\"https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-7-1024x188.png\" alt=\"\" class=\"wp-image-12660\" style=\"aspect-ratio:5.446950015587655;width:585px;height:auto\" srcset=\"https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-7-1024x188.png 1024w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-7-300x55.png 300w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-7-768x141.png 768w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-7-1536x282.png 1536w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-7-18x3.png 18w, https:\/\/csiag.eu\/wp-content\/uploads\/2023\/12\/image-7.png 1668w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Dosierungsempfehlungen\"><\/span>Dosage recommendations<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Scientific studies typically use:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Preventive<br>5-25 mg sulforaphane per day<\/li>\n\n\n\n<li>Therapeutic<br>30-90 mg sulforaphane per day<br>Corresponds to approx. 0.4 mg sulforaphane per kg body weight<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Optimierung_der_Sulforaphan-Bildung\"><\/span><strong>Optimization of sulforaphane formation<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Myrosinase is destroyed at &gt; 60\u00b0C<br>Broccoli only raw or briefly steamed (&lt; 5 minutes at &lt; 60\u00b0C)<\/li>\n\n\n\n<li>Chew thoroughly<br>activates myrosinase<\/li>\n\n\n\n<li>After cutting, wait approx. 40-90 minutes before heating <br>triples the sulforaphane content<\/li>\n\n\n\n<li>alternative<br>Add mustard powder to the cooked broccoli (provides myrosinase)<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Qualitatskriterien\"><\/span>Quality criteria<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Glucoraphanin + myrosinase<br>preferred (highest stability)<\/li>\n\n\n\n<li>Laboratory-tested batches <br>with salary slips<\/li>\n\n\n\n<li>Made from broccoli seeds or sprouts<br>Highest content<\/li>\n\n\n\n<li>Stabilized sulforaphane (prostaphane)<br>Highest bioavailability, but only available in Europe<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Darmgesundheit_ist_Voraussetzung\"><\/span>Gut health is a prerequisite<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>The intestine plays the most important role in the conversion of glucoraphanin into sulforaphane. If the intestinal flora is disturbed, the conversion of the supplied glucoraphanin into the required sulforaphane cannot take place to a sufficient extent.<\/p>\n\n\n\n<p>One possibility is a bowel cleansing \/ detoxification \/ bowel treatment or, if this would be too much of a burden for health reasons, the use of preparations with <em>Myrosinase<\/em> necessary.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wirkung\"><\/span>Effect<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>While well-known antioxidants such as vitamin C, E, \u03b2-carotene neutralize free radicals directly <em>Sulforaphane<\/em> another, more effective way.<\/p>\n\n\n\n<p>It activates phase II enzymes, which trigger the body&#039;s own defense mechanisms of an antioxidant nature. <em>Sulforaphane<\/em> destroyed <em>Microtubules<\/em>, the cytoskeleton, as well as essential metabolic pathways of the tumor cells and thus leads to their destruction.<\/p>\n\n\n\n<p>In addition to these effects, which are important for carcinomas, wait <em>Sulforaphane<\/em> with other positive properties.<br>This is intended, among other things, to combat the germ responsible for stomach ulcers <em>Helicobacter pylori<\/em>, as well as other germs that have become resistant to conventional antibiotics, can be effective.<br>A beneficial effect on total cholesterol, LDL and triglycerides, as well as liver enzymes has also been described.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"Studien_P\"><span class=\"ez-toc-section\" id=\"Studien\"><\/span>Studies<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Historical discovery - 1997<br><a href=\"https:\/\/www.sciencedaily.com\/releases\/1997\/09\/970919062654.htm\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.sciencedaily.com\/releases\/1997\/09\/970919062654.htm<\/a><\/li>\n\n\n\n<li>John Hopkins - 2023<br><a href=\"https:\/\/hub.jhu.edu\/magazine\/2023\/spring\/broccoli-sprouts-health-research\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/hub.jhu.edu\/magazine\/2023\/spring\/broccoli-sprouts-health-research\/<\/a><\/li>\n\n\n\n<li>Traka et al, - 2013<br><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3666090\/\" data-type=\"link\" data-id=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3666090\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3666090\/<\/a><\/li>\n\n\n\n<li>Mithen - 2013 - Acta Horticulturae<br><a href=\"https:\/\/www.researchgate.net\/publication\/284250534_Development_and_commercialisation_of_&#039;Beneforte&#039;_broccoli_and_potential_health_benefits\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.researchgate.net\/publication\/284250534_Development_and_commercialisation_of_&#8217;Beneforte&#8217;_broccoli_and_potential_health_benefits<\/a><\/li>\n\n\n\n<li>Qualitative analyses of the University of M\u00fcnster - Hensel &amp; Lechtenberg - 2020 (main publication)<br><a href=\"https:\/\/www.thieme-connect.de\/products\/ejournals\/html\/10.1055\/a-1126-9287\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.thieme-connect.de\/products\/ejournals\/html\/10.1055\/a-1126-9287<\/a><\/li>\n\n\n\n<li>Lechtenberg et al. (2023) - Sprouted seeds<br><a href=\"https:\/\/www.thieme-connect.com\/products\/ejournals\/abstract\/10.1055\/a-2179-8902\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.thieme-connect.com\/products\/ejournals\/abstract\/10.1055\/a-2179-8902<\/a><\/li>\n\n\n\n<li>Publication list<br><a href=\"https:\/\/www.uni-muenster.de\/Chemie.pb\/forschung\/NEM-Botanicals\/Publikationsliste_NEM-Botanicals.html\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.uni-muenster.de\/Chemie.pb\/forschung\/NEM-Botanicals\/Publikationsliste_NEM-Botanicals.html<\/a><\/li>\n\n\n\n<li>Bioavailability study 2019<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31261930\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/31261930\/<\/a><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Prostata-CA\"><\/span>Prostate CA<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>16.09.2025 - <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12451241\/\" target=\"_blank\" rel=\"noreferrer noopener\">Sulforaphane as a potential therapeutic agent: a comprehensive analysis of clinical trials and mechanistic insights<\/a><br>Prostate cancer studies showed that sulforaphane altered the expression of oncogenic genes in prostate tissue but did not reduce PSA levels in plasma - Full text<\/li>\n\n\n\n<li>24.11.2023 - <a href=\"https:\/\/www.frontiersin.org\/journals\/oncology\/articles\/10.3389\/fonc.2023.1251895\/full\" target=\"_blank\" rel=\"noreferrer noopener\">Efficacy and tolerability of sulforaphane in the therapeutic management of cancers<\/a><br>Different dosing regimens, sulforaphane treatment led to statistically significant changes in several important genes and histological biomarkers<br>Full text<\/li>\n\n\n\n<li>16.06.2023 - <a href=\"https:\/\/www.frontiersin.org\/journals\/oncology\/articles\/10.3389\/fonc.2023.1168321\/full\" target=\"_blank\" rel=\"noreferrer noopener\">Anticancer properties of sulforaphane: current insights at the molecular level<\/a><br>Full text<\/li>\n\n\n\n<li>10.04.2023 - <a href=\"https:\/\/www.mdpi.com\/1422-0067\/24\/8\/6979\" target=\"_blank\" rel=\"noreferrer noopener\">Sulforaphane and Its Protective Role in Prostate Cancer: A Mechanistic Approach<\/a><br>Review of mechanisms of action<br>Full text<\/li>\n\n\n\n<li>23.01.23 - <a href=\"Sulforaphane: An emergent anti-cancer stem cell agent\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.frontiersin.org\/journals\/oncology\/articles\/10.3389\/fonc.2023.1089115\/full<\/a><br>Full text<\/li>\n\n\n\n<li>20.04.2021 - <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33877541\/\" target=\"_blank\" rel=\"noreferrer noopener\">Sulforaphane as a Promising Natural Molecule for Cancer Prevention and Treatment <\/a><br>in addition to the abridged version linked here, unfortunately only available in full text - for a fee<\/li>\n\n\n\n<li>18.11.2020 - <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33218199\/\" target=\"_blank\" rel=\"noreferrer noopener\">Sulforaphane Reduces Prostate Cancer Cell Growth and Proliferation In Vitro by Modulating the Cdk-Cyclin Axis and Expression of the CD44 Variants 4, 5, and 7<\/a><br>specialized study provides deeper insights<br>Full text<\/li>\n\n\n\n<li>15.04.2019 - <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0002916522031719\" target=\"_blank\" rel=\"noreferrer noopener\">Transcriptional changes in prostate of men on active surveillance after a 12-mo glucoraphanin-rich broccoli intervention<\/a><br>RNA sequencing showed dose-dependent inhibition of oncogenic signaling pathways including TGF-\u03b2, KRAS, NF-\u03baB and Notch<\/li>\n\n\n\n<li>03.08.2015 - <a href=\"https:\/\/aacrjournals.org\/cancerpreventionresearch\/article\/8\/8\/712\/50472\/Effect-of-Sulforaphane-in-Men-with-Biochemical\" target=\"_blank\" rel=\"noreferrer noopener\">Effect of Sulforaphane in Men with Biochemical Recurrence after Radical Prostatectomy<\/a><br>PSA doubling time was 86% longer in the sulforaphane group (28.9 months) than in the placebo group (15.5 months)<br>Full text<\/li>\n<\/ul>\n\n\n\n<p>For those who do not speak medical English, please refer to the German-language and basic publications from the Heidelberg University Hospital mentioned at the beginning.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Pankreas-CA\"><\/span>Pancreas CA<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>Notice<\/strong>: If you have advanced pancreatic cancer, you should talk to your doctor, as high-dose broccoli sprout supplements can increase nausea and vomiting during chemotherapy.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>04.12.2024 - <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11617590\/\" target=\"_blank\" rel=\"noreferrer noopener\">Anti-Cancer Effect of Sulforaphane in Human Pancreatic Cancer Cells Mia PaCa-2<\/a><br>Sulforaphane inhibits GSK-3\u03b2 activity by phosphorylating Ser9; inactivation of GSK-3\u03b2 increases apoptosis through \u03b2-catenin\/caspase-3\/PRAR and NF-\u03baB\/BCL-2 signaling pathways - available in full text<\/li>\n\n\n\n<li>29.08.2024 - <a href=\"https:\/\/www.frontiersin.org\/journals\/oncology\/articles\/10.3389\/fonc.2024.1442737\/full\" target=\"_blank\" rel=\"noreferrer noopener\">Sulforaphane regulates cell proliferation and induces apoptotic cell death mediated by ROS-cell cycle arrest in pancreatic cancer cells<\/a><br>Sulforaphane induces apoptosis through ROS cell cycle arrest, also available as full text<\/li>\n\n\n\n<li>24.11.2023) - <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10710291\/\" target=\"_blank\" rel=\"noreferrer noopener\">Efficacy and tolerability of sulforaphane in the therapeutic management of cancers: a systematic review of randomized controlled trials<\/a> <br>freely available full text publication<\/li>\n\n\n\n<li>27.06.2019 - <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7211206\/\" target=\"_blank\" rel=\"noopener\">Broccoli sprout supplementation in patients with advanced pancreatic cancer is difficult despite positive effects-results from the POUDER pilot study<\/a><br><strong>Dosage:<\/strong> 15 capsules daily with 90 mg\/508 \u03bcmol sulforaphane and 180 mg\/411 \u03bcmol glucoraphanin for up to 1 year<br><strong>Results:<\/strong> Lower mean mortality rate in the treatment group during the first 6 months (day 30: 0%\/18%)<br><strong>Restrictions:<\/strong> High discontinuation rate (72%), some patients had difficulty with 15 capsules daily<\/li>\n\n\n\n<li>05.05.2019 - <a href=\"https:\/\/www.cell.com\/molecular-therapy-family\/oncology\/fulltext\/S2372-7705(19)30047-6\" target=\"_blank\" rel=\"noreferrer noopener\">Sulforaphane Induces miR135b-5p and Its Target Gene, RASAL2, thereby Inhibiting the Progression of Pancreatic Cancer<\/a><br>also describes the disruption of the miR135b-5p\/RASAL2 signaling pathway, which is important for tumor growth, and is available in full text free of charge<\/li>\n\n\n\n<li>22.01.2014) <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4039235\/\" target=\"_blank\" rel=\"noreferrer noopener\">Sulforaphane counteracts aggressiveness of pancreatic cancer driven by dysregulated Cx43-mediated gap junctional intercellular communication<\/a><br>deals with the dysregulation (disruption) of the communication pathway between tumor cells by sulforaphane, also available free of charge in full text<\/li>\n\n\n\n<li>01.12.2013 - <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3386376\/\" target=\"_blank\" rel=\"noreferrer noopener\">Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50<sup>Cdc37<\/sup>\u00a0complex and direct interactions with amino acid residues of Hsp90<\/a><br>in free full text version<\/li>\n\n\n\n<li>23.03.2012 - <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3386376\/\" target=\"_blank\" rel=\"noreferrer noopener\">Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50Cdc37 complex<\/a><br>Sulforaphane disrupts the Hsp90 complex and induces degradation of Hsp90 client proteins<br>Full text<\/li>\n\n\n\n<li>29.08.2011 - <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3850054\/\" target=\"_blank\" rel=\"noreferrer noopener\">Sulforaphane Potentiates the Efficacy of 17-AAG Against Pancreatic Cancer<\/a><br>Co-administration of sulforaphane and 17-AAG in the xenograft model resulted in over 70% inhibition of tumor growth, while 17-AAG alone suppressed only 50%<br>Full text<\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p><span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Reading time<\/span> <span class=\"rt-time\"> 6<\/span> <span class=\"rt-label rt-postfix\">minutes<\/span><\/span>If a prostate CA or pancreatic CA (carcinoma) is suspected, a biopsy either brings the longed-for relief or sobering confirmation of the suspected diagnosis. But what can be done to effectively prevent or even, in the early stages, to avoid an operation with significant consequences and stress? This is the question that the Heidelberg University Clinic is addressing with regard to prostate...&nbsp;<a href=\"https:\/\/csiag.eu\/en\/blog\/2023\/12\/15\/verdacht-auf-prostata-pankreas-ca\/\" rel=\"bookmark\">Read More \"<span class=\"screen-reader-text\">Suspected prostate CA\/pancreas CA?<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[1078,354,2811,2812],"tags":[2818,2844,2832,2831,2825,2837,2826,1462,2846,2824,2833,2834,2842,2843,2835,2838,2839,2840,2827,2814,2813,2816,2815,2841,183,2822,2823,2830,2829,1470,1747,2817,2836,2819,2820,2828,2845,2821],"class_list":["post-5951","post","type-post","status-publish","format-standard","hentry","category-medizin","category-medizin-gesundheit","category-pankreas-ca","category-prostata-ca","tag-antioxidantien","tag-apoptose","tag-carcinom","tag-carcinome","tag-forschung","tag-gesamtcholesterin","tag-glucoraphanin","tag-helicobacter-pylori","tag-hydrolyse","tag-isothiocyanat","tag-karzinom","tag-karzinome","tag-keim","tag-keime","tag-ldl","tag-leberenzyme","tag-magengeschwuer","tag-magengeschwuere","tag-mikrotubuli","tag-pankreas","tag-pankreas-ca","tag-prostata","tag-prostata-ca","tag-resistent","tag-resistenz","tag-senfoel","tag-senfoelglykosid","tag-signalwege","tag-stoffwechselwege","tag-studie","tag-studien","tag-sulforaphan","tag-triglyceride","tag-vitamin-c","tag-vitamin-e","tag-zellskelett","tag-zelltod","tag--carotin"],"modified_by":"Achim Goerner","_links":{"self":[{"href":"https:\/\/csiag.eu\/en\/wp-json\/wp\/v2\/posts\/5951","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csiag.eu\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csiag.eu\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csiag.eu\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csiag.eu\/en\/wp-json\/wp\/v2\/comments?post=5951"}],"version-history":[{"count":0,"href":"https:\/\/csiag.eu\/en\/wp-json\/wp\/v2\/posts\/5951\/revisions"}],"wp:attachment":[{"href":"https:\/\/csiag.eu\/en\/wp-json\/wp\/v2\/media?parent=5951"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csiag.eu\/en\/wp-json\/wp\/v2\/categories?post=5951"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csiag.eu\/en\/wp-json\/wp\/v2\/tags?post=5951"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}