{"id":10036,"date":"2025-06-02T19:05:44","date_gmt":"2025-06-02T19:05:44","guid":{"rendered":"https:\/\/csiag.eu\/?p=10036"},"modified":"2025-06-03T20:37:17","modified_gmt":"2025-06-03T20:37:17","slug":"az-lnp-toxicitasa-a-csaplanc-hosszatol-fueggoen","status":"publish","type":"post","link":"https:\/\/csiag.eu\/hu\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/","title":{"rendered":"Az LNP toxicit\u00e1sa a PEG-l\u00e1nc hossz\u00e1t\u00f3l f\u00fcgg\u0151en"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Tartalomjegyz\u00e9k<\/p>\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/csiag.eu\/hu\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Welche_LNPs_wurden_verwendet\" >Milyen LNP-ket haszn\u00e1ltak?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/csiag.eu\/hu\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Toxizitat_wurde_nicht_durch_Studien_uberpruft\" >A toxicit\u00e1st nem igazolt\u00e1k vizsg\u00e1latokkal.<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/csiag.eu\/hu\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Akkumulation_in_der_Leber\" >Felhalmoz\u00f3d\u00e1s a m\u00e1jban<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/csiag.eu\/hu\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Der_Weg_in_die_Leber_und_die_Lange_der_Kette\" >A m\u00e1jba vezet\u0151 \u00fat \u00e9s a l\u00e1nc hossza<\/a><\/li><\/ul><\/nav><\/div>\n<span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Olvas\u00e1si id\u0151<\/span> <span class=\"rt-time\"> 2<\/span> <span class=\"rt-label rt-postfix\">percek<\/span><\/span>\n<p>Min\u00e9l r\u00f6videbb a PEG-l\u00e1nc (polietil\u00e9nglikol), ann\u00e1l nagyobb az LNP toxicit\u00e1sa. A BioNTech ezt a <a href=\"https:\/\/www.mdpi.com\/2227-9059\/9\/5\/530\" target=\"_blank\" rel=\"noreferrer noopener\">Kiadv\u00e1ny<\/a> \"Non-Immunotherapy Application of LNP-mRNA: Maximising Efficacy and Safety\" (Az LNP-mRNS nem immunter\u00e1pi\u00e1s alkalmaz\u00e1sa: a hat\u00e9konys\u00e1g \u00e9s a biztons\u00e1g maximaliz\u00e1l\u00e1sa), 10.05.2021, b\u00e1r - kiss\u00e9 - m\u00e1sk\u00e9pp fogalmazva: \"Maximising Efficacy\".<br>A toxicit\u00e1s alapja az a t\u00e9ny, hogy mindh\u00e1rom ioniz\u00e1lhat\u00f3 kationos lipid nem biol\u00f3giailag leboml\u00f3, \u00e9s a szervezetben val\u00f3 elker\u00fclhetetlen felhalmoz\u00f3d\u00e1suknak citotoxikus k\u00f6vetkezm\u00e9nyei vannak.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Welche_LNPs_wurden_verwendet\"><\/span>Milyen LNP-ket haszn\u00e1ltak?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><em>Pfizer<\/em> \/ <em>BioNTech<\/em> - BNT162b2 - <a href=\"https:\/\/www.echelon-inc.com\/product\/alc-0315\/\" target=\"_blank\" rel=\"noreferrer noopener\">ALC-0315<\/a> (ioniz\u00e1lhat\u00f3) \u00e9s <a href=\"https:\/\/www.echelon-inc.com\/product\/alc-0159\/\" target=\"_blank\" rel=\"noreferrer noopener\">ALC-0159<\/a> (PEGil\u00e1lt)<br><em>Moderna<\/em> - <a href=\"https:\/\/www.echelon-inc.com\/product\/sm-102\/\" target=\"_blank\" rel=\"noreferrer noopener\">SM-102<\/a> (ioniz\u00e1lhat\u00f3) \u00e9s <a href=\"https:\/\/www.echelon-inc.com\/product\/dmg-peg-2000\/\" target=\"_blank\" rel=\"noreferrer noopener\">PEG2000-DMG<\/a> (PEGil\u00e1lt)<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"562\" src=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-1024x562.png\" alt=\"\" class=\"wp-image-10045\" srcset=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-1024x562.png 1024w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-300x165.png 300w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-768x421.png 768w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-18x10.png 18w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image.png 1456w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<p>A fent eml\u00edtett valamennyi lipid eset\u00e9ben a gy\u00e1rt\u00f3k (pl. <a href=\"https:\/\/www.echelon-inc.com\/product\/alc-0315\/#tab-description\" target=\"_blank\" rel=\"noreferrer noopener\">Echelon Biosciences<\/a>) \"... Ez egy reagens min\u0151s\u00e9g\u0171 term\u00e9k, kiz\u00e1r\u00f3lag kutat\u00e1si c\u00e9lra.\"<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Toxizitat_wurde_nicht_durch_Studien_uberpruft\"><\/span>A toxicit\u00e1st nem igazolt\u00e1k vizsg\u00e1latokkal.<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>A <a href=\"https:\/\/www.tga.gov.au\/sites\/default\/files\/foi-2389-06.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Kiadv\u00e1ny<\/a> Az ausztr\u00e1l korm\u00e1ny - Eg\u00e9szs\u00e9g\u00fcgyi Miniszt\u00e9rium 2021. janu\u00e1ri \"BNT 162b2 mRNS COVID-19 vakcina COMIRNATY\u2122 nem klinikai \u00e9rt\u00e9kel\u00e9si jelent\u00e9se\" c\u00edm\u0171, 2021. janu\u00e1ri kiadv\u00e1ny\u00e1nak 11. oldal\u00e1n olvashat\u00f3: \"Az LNP formul\u00e1ci\u00f3 vagy az \u00faj seg\u00e9danyagok toxicit\u00e1s\u00e1t \u00f6nmag\u00e1ban nem vizsg\u00e1lt\u00e1k k\u00fcl\u00f6n\".<br>M\u00e1s sz\u00f3val, a fent eml\u00edtett \u00faj LNP seg\u00e9danyagok haszn\u00e1lat\u00e1r\u00f3l \u00e9s hat\u00e1sair\u00f3l nem v\u00e9geztek toxicit\u00e1si vizsg\u00e1latokat.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Akkumulation_in_der_Leber\"><\/span>Felhalmoz\u00f3d\u00e1s a m\u00e1jban<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Sok gy\u00f3gyszer r\u00e9szben vagy teljesen a m\u00e1jban metaboliz\u00e1l\u00f3dik, \u00e9s a v\u00e9r\u00e1ramba ker\u00fcl. A fent eml\u00edtett ALC-315 seg\u00e9danyag is felhalmoz\u00f3dik a m\u00e1jban, amint az a <a href=\"https:\/\/www.judicialwatch.org\/wp-content\/uploads\/2022\/03\/JW-v-HHS-prod-3-02418.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">R\u00e9szleges v\u00e1lasz a 2021-4379. sz. k\u00e9rd\u00e9sre<\/a> az inform\u00e1ci\u00f3szabads\u00e1gr\u00f3l sz\u00f3l\u00f3 t\u00f6rv\u00e9ny (FOIA) alapj\u00e1n, amely a Judicial Watch, Inc. kontra U.S. Department of Health and Human Services (21-cv-2418) \u00fcgyben beny\u00fajtott panasz t\u00e1rgy\u00e1t k\u00e9pezi, amely jelenleg az U.S. District Court for the District of Columbia el\u0151tt van folyamatban, a 466. oldal 16. oldal\u00e1n:<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"542\" src=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-1024x542.png\" alt=\"\" class=\"wp-image-10054\" srcset=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-1024x542.png 1024w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-300x159.png 300w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-768x407.png 768w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-18x10.png 18w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3.png 1212w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>A fent eml\u00edtett jelent\u00e9s 45. oldal\u00e1n is szerepel. <a href=\"https:\/\/www.tga.gov.au\/sites\/default\/files\/foi-2389-06.pdf\" target=\"_blank\" rel=\"noopener\">Jelent\u00e9sek<\/a>:<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"55\" src=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-1024x55.png\" alt=\"\" class=\"wp-image-10060\" srcset=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-1024x55.png 1024w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-300x16.png 300w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-768x42.png 768w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-18x1.png 18w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4.png 1218w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>A 46. oldalon in vitro k\u00eds\u00e9rletek alapj\u00e1n felv\u00e1zolj\u00e1k a puszt\u00e1n elm\u00e9letileg felt\u00e9telezett metabolikus \u00fatvonalat, b\u00e1r ezt embereken nem ellen\u0151rizt\u00e9k.<\/p>\n\n\n\n<p>M\u00edg a <a href=\"https:\/\/www.statnews.com\/2017\/01\/10\/moderna-trouble-mrna\/\" target=\"_blank\" rel=\"noreferrer noopener\">Moderna<\/a> a m\u00e1j inkompatibilit\u00e1s miatt le\u00e1ll\u00edtotta az ALC-0315-\u00f6t, \u00e9s saj\u00e1t maga fejlesztette ki az SM platformot (az ALC-0315 t\u00fal m\u00e9rgez\u0151nek bizonyult a Crigler-Najjar szindr\u00f3ma m\u00e1jbetegs\u00e9g g\u00e9nter\u00e1pi\u00e1j\u00e1hoz, \u00edgy az akkori kutat\u00e1si partnere <em>Alexion<\/em> biztons\u00e1gi okokb\u00f3l le\u00e1ll\u00edtotta a vizsg\u00e1latot), a BioNTech \/ Pfizer a jobb bel\u00e1t\u00e1sa ellen\u00e9re tov\u00e1bbra is haszn\u00e1lja \u0151ket.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Der_Weg_in_die_Leber_und_die_Lange_der_Kette\"><\/span>A m\u00e1jba vezet\u0151 \u00fat \u00e9s a l\u00e1nc hossza<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><\/p>\n\n\n\n<p>... folytat\u00f3dik ...<\/p>","protected":false},"excerpt":{"rendered":"<p><span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Olvas\u00e1si id\u0151<\/span> <span class=\"rt-time\"> 2<\/span> <span class=\"rt-label rt-postfix\">percek<\/span><\/span>Min\u00e9l r\u00f6videbb a PEG-l\u00e1nc (polietil\u00e9nglikol), ann\u00e1l nagyobb az LNP toxicit\u00e1sa. A BioNTech ezt a \"Non-Immunotherapy Application of LNP-mRNA: Maximising Efficacy and Safety\" c\u00edm\u0171, 2021.05.10-i publik\u00e1ci\u00f3j\u00e1ban magyar\u00e1zza, b\u00e1r - n\u00e9mileg - m\u00e1sk\u00e9pp fogalmazva: \"Maximising Efficacy\" A toxicit\u00e1s alapja, hogy mindh\u00e1rom ioniz\u00e1lhat\u00f3 kationos lipid biol\u00f3giailag nem leboml\u00f3, ez\u00e9rt toxicit\u00e1suk...&nbsp;<a href=\"https:\/\/csiag.eu\/hu\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/\" rel=\"bookmark\">Olvass tov\u00e1bb \"<span class=\"screen-reader-text\">Az LNP toxicit\u00e1sa a PEG-l\u00e1nc hossz\u00e1t\u00f3l f\u00fcgg\u0151en<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[628,316,1078],"tags":[5067,5066,5074,22,36,5080,5079,5069,5075,5071,4812,105,5073,5077,5070,5072,23,5076,5078,44],"class_list":["post-10036","post","type-post","status-publish","format-standard","hentry","category-corona","category-corona-blog","category-medizin","tag-alc-159","tag-alc-315","tag-alnylam","tag-biontech","tag-bnt162b2","tag-cholesterol","tag-dlin-mc3-dma","tag-dmg-peg2000","tag-elasomeran","tag-ionisierbar","tag-lnp","tag-moderna","tag-patisiran","tag-peg-lipid","tag-peg2000-dmg","tag-pegyliert","tag-pfizer","tag-phosholipid","tag-sterol","tag-tozinameran"],"modified_by":"Achim Goerner","_links":{"self":[{"href":"https:\/\/csiag.eu\/hu\/wp-json\/wp\/v2\/posts\/10036","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csiag.eu\/hu\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csiag.eu\/hu\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csiag.eu\/hu\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csiag.eu\/hu\/wp-json\/wp\/v2\/comments?post=10036"}],"version-history":[{"count":0,"href":"https:\/\/csiag.eu\/hu\/wp-json\/wp\/v2\/posts\/10036\/revisions"}],"wp:attachment":[{"href":"https:\/\/csiag.eu\/hu\/wp-json\/wp\/v2\/media?parent=10036"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csiag.eu\/hu\/wp-json\/wp\/v2\/categories?post=10036"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csiag.eu\/hu\/wp-json\/wp\/v2\/tags?post=10036"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}