{"id":12718,"date":"2026-02-17T18:46:40","date_gmt":"2026-02-17T18:46:40","guid":{"rendered":"https:\/\/csiag.eu\/?p=12718"},"modified":"2026-02-17T20:56:03","modified_gmt":"2026-02-17T20:56:03","slug":"%e3%83%a2%e3%82%ac%e3%83%89-%e3%83%a2%e3%82%b0%e6%8a%97%e4%bd%93%e9%96%a2%e9%80%a3%e7%96%be%e6%82%a3","status":"publish","type":"post","link":"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/","title":{"rendered":"MOGAD - MOG\u6297\u4f53\u95a2\u9023\u75be\u60a3"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u76ee\u6b21<\/p>\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Was_ist_MOGAD\" >MOGAD\u3068\u306f\uff1f<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Was_geht_bei_MOGAD_schief\" >MOGAD\u306e\u4f55\u304c\u554f\u984c\u306a\u306e\u304b\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Wo_im_Korper_passiert_das\" >\u3053\u308c\u306f\u4f53\u306e\u3069\u3053\u3067\u8d77\u3053\u308b\u306e\u304b\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Wie_verlauft_die_Erkrankung\" >\u75c5\u6c17\u306f\u3069\u306e\u3088\u3046\u306b\u9032\u884c\u3059\u308b\u306e\u3067\u3059\u304b\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Wie_haufig_ist_MOGAD\" >MOGAD\u306f\u3069\u306e\u304f\u3089\u3044\u4e00\u822c\u7684\u306a\u306e\u3067\u3059\u304b\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Was_lost_MOGAD_aus\" >\u4f55\u304cMOGAD\u3092\u8a98\u767a\u3059\u308b\u306e\u304b\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Wie_wird_MOGAD_behandelt\" >MOGAD\u306e\u6cbb\u7642\u6cd5\u306f\uff1f<\/a><\/li><\/ul><\/li><\/ul><\/li>\u3002<li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Wissenschaftliche_Einleitung_und_Definition\" >\u79d1\u5b66\u7684\u306a\u5c0e\u5165\u3068\u5b9a\u7fa9<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Abgrenzung_von_MOGAD_NMOSD_und_MS\" >MOGAD\u3001NMOSD\u3001MS\u306e\u9451\u5225<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#MOG-Protein_%E2%80%93_Struktur_und_physiologische_Funktion\" >MOG\u30bf\u30f3\u30d1\u30af\u8cea - \u69cb\u9020\u3068\u751f\u7406\u6a5f\u80fd<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Strukturdomanen\" >\u69cb\u9020\u30c9\u30e1\u30a4\u30f3<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Physiologische_Funktionen\" >\u751f\u7406\u7684\u6a5f\u80fd<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Pathogenese_und_Immunpathologie\" >\u75c5\u56e0\u3068\u514d\u75ab\u75c5\u7406\u5b66<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Trigger_und_initiale_Aktivierung\" >\u30c8\u30ea\u30ac\u30fc\u3068\u521d\u56de\u8d77\u52d5<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#T-Zell-vermittelte_Pathogenese\" >T\u7d30\u80de\u3092\u4ecb\u3057\u305f\u75c5\u56e0<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Phase_1_%E2%80%93_Periphere_Aktivierung\" >\u30d5\u30a7\u30fc\u30ba1 - \u672b\u68a2\u306e\u6d3b\u6027\u5316<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Phase_2_%E2%80%93_BHS-Penetration\" >\u30d5\u30a7\u30fc\u30ba2 - BHS\u306e\u6d78\u900f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Phase_3_%E2%80%93_Perivaskulare_Reaktivierung\" >\u30d5\u30a7\u30fc\u30ba3-\u8840\u7ba1\u5468\u56f2\u306e\u518d\u6d3b\u6027\u5316<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#B-Zell-_und_Antikorper-vermittelte_Pathogenese\" >B\u7d30\u80de\u304a\u3088\u3073\u6297\u4f53\u3092\u4ecb\u3057\u305f\u75c5\u56e0<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Molekulare_Signalwege_und_Effektormechanismen\" >\u5206\u5b50\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3068\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u6a5f\u69cb<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Signalweg_1_%E2%80%93_Klassischer_Komplementweg_CDC\" >\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def1 - \u53e4\u5178\u7684\u88dc\u4f53\u7d4c\u8def\uff08CDC\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Signalweg_2_%E2%80%93_Fc%CE%B3-Rezeptor-Weg_FcR-vermittelt\" >\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def2 - Fc\u03b3\u53d7\u5bb9\u4f53\u7d4c\u8def\uff08FcR\u3092\u4ecb\u3057\u305f\u7d4c\u8def\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Signalweg_3_%E2%80%93_IL-6JAK-STAT3-Weg\" >\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def3 - IL-6\/JAK-STAT3\u7d4c\u8def<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Signalweg_4_%E2%80%93_MAPK-_und_AKT-Signalwege_B-Zellen\" >\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def4 - MAPK\u304a\u3088\u3073AKT\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\uff08B\u7d30\u80de\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Signalweg_5_%E2%80%93_Th17-Zytokin-Netzwerk_im_ZNS\" >\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def5-\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306b\u304a\u3051\u308bTh17\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30cd\u30c3\u30c8\u30ef\u30fc\u30af<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-26\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Signalwege_%E2%80%93_Ubersicht\" >\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def - \u6982\u8981<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-27\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Relevante_Rezeptoren_und_Zielmolekule\" >\u95a2\u9023\u53d7\u5bb9\u4f53\u3068\u6a19\u7684\u5206\u5b50<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-28\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#MOG_selbst_als_Zielstruktur_kein_klassischer_Rezeptor\" >\u6a19\u7684\u69cb\u9020\u3068\u3057\u3066\u306eMOG\u305d\u306e\u3082\u306e\uff08\u53e4\u5178\u7684\u306a\u53d7\u5bb9\u4f53\u3067\u306f\u306a\u3044\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-29\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Fc%CE%B3-Rezeptoren_Fc%CE%B3R\" >Fc\u03b3\u53d7\u5bb9\u4f53\uff08Fc\u03b3R\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-30\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Neonataler_Fc-Rezeptor_FcRn\" >\u65b0\u751f\u5150Fc\u53d7\u5bb9\u4f53\uff08FcRn\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-31\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#IL-6-Rezeptor_IL-6R%CE%B1_gp130\" >IL-6\u53d7\u5bb9\u4f53 (IL-6R\u03b1 \/ gp130)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-32\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#T-Zell-Rezeptor_TCR_und_Kostimulationsmolekule\" >T\u7d30\u80de\u53d7\u5bb9\u4f53\uff08TCR\uff09\u3068\u30b3\u30b9\u30c8\u523a\u6fc0\u5206\u5b50<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-33\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Komplementrezeptoren\" >\u88dc\u4f53\u53d7\u5bb9\u4f53<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-34\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Histopathologie_und_ZNS-Lasionsmuster\" >\u75c5\u7406\u7d44\u7e54\u5b66\u304a\u3088\u3073\u4e2d\u67a2\u795e\u7d4c\u7cfb\u75c5\u5909\u30d1\u30bf\u30fc\u30f3<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-35\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Klinische_Manifestationen_und_Phanotypen\" >\u81e8\u5e8a\u75c7\u72b6\u3068\u8868\u73fe\u578b<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-36\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Diagnostik\" >\u8a3a\u65ad<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-37\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Therapeutische_Strategien\" >\u6cbb\u7642\u6226\u7565<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-38\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Akuttherapie_Schubbehandlung\" >\u6025\u6027\u671f\u6cbb\u7642\uff08\u518d\u767a\u6cbb\u7642\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-39\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Prophylaktische_Langzeittherapie\" >\u4e88\u9632\u7684\u9577\u671f\u7642\u6cd5<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-40\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Klinische_Studien_%E2%80%93_2024%E2%80%932026\" >\u81e8\u5e8a\u8a66\u9a13 - 2024-2026<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-41\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Neue_und_zukunftige_Therapiekonzepte\" >\u65b0\u3057\u3044\u3001\u305d\u3057\u3066\u672a\u6765\u306e\u6cbb\u7642\u30b3\u30f3\u30bb\u30d7\u30c8<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-42\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#BTK-Inhibitoren_Bruton-Tyrosin-Kinase\" >BTK\u963b\u5bb3\u5264\uff08\u30d6\u30eb\u30c8\u30f3\u578b\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-43\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Toleranzinduktion_MOG-Tolerisierung\" >\u5bdb\u5bb9\u8a98\u5c0e\uff08MOG\u5bdb\u5bb9\u5316\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-44\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Komplementinhibitoren\" >\u88dc\u4f53\u963b\u5bb3\u5264<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-45\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Anti-Neonatal-Fc-Rezeptor-Strategien\" >\u6297\u65b0\u751f\u5150Fc\u30ec\u30bb\u30d7\u30bf\u30fc\u6226\u7565<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-46\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Autologe_hamatopoetische_Stammzelltransplantation_aHSCT\" >\u81ea\u5bb6\u9020\u8840\u5e79\u7d30\u80de\u79fb\u690d\uff08aHSCT\uff09<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-47\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Biomarker_und_Verlaufsmonitoring\" >\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u8ffd\u8de1\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-48\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Prognose_und_Besonderheiten\" >\u4e88\u60f3\u3068\u7279\u96c6<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-49\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Zusammenfassung_und_Ausblick\" >\u7dcf\u62ec\u3068\u5c55\u671b<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-50\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Atherischer_Ole_%E2%80%93_Wirkstoffe_nach_Signalwegen_geordnet\" >\u30a8\u30c3\u30bb\u30f3\u30b7\u30e3\u30eb\u30aa\u30a4\u30eb - \u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u5225\u306b\u5206\u985e\u3055\u308c\u305f\u6709\u52b9\u6210\u5206<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-51\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Weihrauch_Boswellia_serrata_%E2%80%93_AKBA_und_Incensolacetat\" >\u30d5\u30e9\u30f3\u30ad\u30f3\u30bb\u30f3\u30b9\uff08Boswellia serrata\uff09 - AKBA\u304a\u3088\u3073\u9162\u9178\u30a4\u30f3\u30bb\u30f3\u30bd\u30fc\u30eb<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-52\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Therapeutisch_relevante_AKBA-Zieldosen\" >AKBA\u306e\u6cbb\u7642\u76ee\u7684\u7528\u91cf<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-53\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Umrechnung_auf_375_mg_AKBA_jeKapsel\" >1\u30ab\u30d7\u30bb\u30eb\u3042\u305f\u308aAKBA 37.5mg\u3078\u306e\u63db\u7b97<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-54\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Wichtige_Einnahmehinweise\" >\u6442\u53d6\u306b\u95a2\u3059\u308b\u91cd\u8981\u306a\u6307\u793a<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-55\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Schwarzer_Pfeffer_oral\" >\u30d6\u30e9\u30c3\u30af\u30da\u30c3\u30d1\u30fc\uff08\u7d4c\u53e3\uff09<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-56\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Schwarzer_Pfeffer_Inhalation\" >\u30d6\u30e9\u30c3\u30af\u30da\u30c3\u30d1\u30fc\uff08\u5438\u5165\uff09<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-57\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Copaiba-Ol_oral_%E2%80%93_NUR_doTERRA\" >\u30b3\u30d1\u30a4\u30d0\u30aa\u30a4\u30eb\uff08\u7d4c\u53e3\uff09-\u30c9\u30c6\u30e9\u793e\u306e\u307f<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-58\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#MOGAD-spezifische_Dosierungstabelle_doTERRA_Copaiba_525_BCP\" >MOGAD\u5c02\u7528\u670d\u7528\u8868\uff08doTERRA \u30b3\u30d1\u30a4\u30d052.5 % BCP\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-59\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#MOGAD-Phasen-adaptierte_Dosierung\" >MOGAD\u76f8\u9806\u6295\u4e0e<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-60\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Phase_1_Akuter_Schub_erste_2%E2%80%934_Wochen\" >\u7b2c1\u6bb5\u968e\uff1a\u6025\u6027\u5897\u60aa\u671f\uff08\u6700\u521d\u306e2\uff5e4\u9031\u9593\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-61\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Phase_2_Schubremission_Erhaltung_langfristig\" >\u30d5\u30a7\u30fc\u30ba2\uff1a\u518d\u767a\u5bdb\u89e3\uff0f\u7dad\u6301\uff08\u9577\u671f\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-62\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Phase_3_Monophasischer_Verlauf_Titer_fallend\" >\u7b2c3\u6bb5\u968e\uff1a\u5358\u76f8\u30b3\u30fc\u30b9\uff08\u529b\u4fa1\u4f4e\u4e0b\uff09<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-63\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Quellen\" >\u60c5\u5831\u6e90<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-64\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Copaiba-Ol_Inhalation\" >\u30b3\u30d1\u30a4\u30d0\u30aa\u30a4\u30eb\uff08\u5438\u5165\uff09<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-65\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Zieldosen_und_benotigte_Tropfenzahl\" >\u76ee\u6a19\u6295\u4e0e\u91cf\u3068\u5fc5\u8981\u6ef4\u6570<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-66\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Synergistische_MOGAD-Strategie_Multi-Target\" >\u76f8\u4e57\u7684MOGAD\u6226\u7565\uff08\u30de\u30eb\u30c1\u30bf\u30fc\u30b2\u30c3\u30c8\uff09<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-67\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Wichtige_MOGAD-spezifische_Hinweise\" >MOGAD\u56fa\u6709\u306e\u91cd\u8981\u60c5\u5831<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-68\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#%CE%B1-Asaron_Kalmus-Ol_Acorus_calamus_%E2%80%93_direkt_oligodendrozytenprotektiv\" >\u03b1-\u30a2\u30b5\u30ed\u30f3\uff08\u30ab\u30e9\u30de\u30b9\u6cb9\u3001Acorus calamus\uff09 - \u76f4\u63a5\u7684\u306a\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u4fdd\u8b77\u4f5c\u7528\u304c\u3042\u308b\u3002<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-69\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Geraniumol_Pelargonium_graveolens_%E2%80%93_Neuroinflammation_und_NO\" >\u30bc\u30e9\u30cb\u30a6\u30e0\u6cb9\uff08Pelargonium graveolens\uff09 - \u795e\u7d4c\u708e\u75c7\u3068NO<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-70\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Teebaum-Ol_Melaleuca_alternifolia_%E2%80%93_Mikroglia-Modulation\" >\u30c6\u30a3\u30fc\u30c4\u30ea\u30fc\u30aa\u30a4\u30eb\uff08\u30e1\u30e9\u30ec\u30a6\u30ab\u30fb\u30aa\u30eb\u30bf\u30f3\u30c6\u30a3\u30d5\u30a9\u30ea\u30a2\uff09-\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u8abf\u7bc0\u4f5c\u7528<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-71\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Wirkstoffubersicht_nach_MOGAD-Signalwegen\" >MOGAD\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306b\u3088\u308b\u6d3b\u6027\u7269\u8cea\u306e\u6982\u8981<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-72\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Quellen_und_weiterfuhrende_Literatur\" >\u60c5\u5831\u6e90\u3068\u53c2\u8003\u6587\u732e<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">\u8aad\u66f8\u6642\u9593<\/span> <span class=\"rt-time\"> 17<\/span> <span class=\"rt-label rt-postfix\">\u8b70\u4e8b\u9332<\/span><\/span>\n<p class=\"wp-block-paragraph\"><em>\u30df\u30a8\u30ea\u30f3\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u6297\u4f53\u95a2\u9023\u75be\u60a3<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Was_ist_MOGAD\"><\/span>MOGAD\u3068\u306f\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u96fb\u6c17\u30b1\u30fc\u30d6\u30eb\u306f\u8ab0\u3082\u304c\u77e5\u3063\u3066\u3044\u308b\uff1a\u30b1\u30fc\u30d6\u30eb\u306f\u3001\u30b1\u30fc\u30d6\u30eb\u675f\u306e\u500b\u3005\u306e\u5c0e\u4f53\u3092\u4e92\u3044\u306b\u5206\u96e2\u3059\u308b\u7d76\u7e01\u4f53\u3092\u5099\u3048\u3066\u304a\u308a\u3001\u30b1\u30fc\u30d6\u30eb\u5185\u306e\u4fe1\u53f7\u304c\u4e92\u3044\u306b\u5e72\u6e09\u3059\u308b\u3053\u3068\u306a\u304f\u3001A\u304b\u3089B\u3078\u6b6a\u307f\u306a\u304f\u5c4a\u304f\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u308b\u3002.<br>\u810a\u9ac4\u306b\u306f\u3001\u305d\u306e\u3088\u3046\u306a\u30b1\u30fc\u30d6\u30eb\u306e\u675f\u304c\u4f55\u672c\u3082\u675f\u306b\u306a\u3063\u3066\u3044\u308b\u3002\u305d\u308c\u3089\u306f\u3001\u8133\u304b\u3089\u306e\u795e\u7d4c\u4fe1\u53f7\u3092\u3001\u4f53\u5185\u306e\u69d8\u3005\u306a\u5668\u5b98\u3001\u7b4b\u8089\u3001 \u7d44\u7e54\u306a\u3069\u306b\u4f1d\u3048\u308b\u3002\u30b1\u30fc\u30d6\u30eb\u306e\u7d76\u7e01\u4f53\u306f\u30d7\u30e9\u30b9\u30c1\u30c3\u30af\u3001\u7e54\u7269\u3001\u307e\u305f\u306f\u7279\u6b8a\u306a\u6750\u6599\u3067\u3067\u304d\u3066\u3044\u308b\u304c\u3001\u810a\u9ac4\u306e\u7d76\u7e01\u5c64\u306f\u7279\u6b8a\u306a\u6750\u6599\u3067\u3067\u304d\u3066\u3044\u308b\u3002 <strong>\u30df\u30a8\u30ea\u30f3\u5c64<\/strong>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Was_geht_bei_MOGAD_schief\"><\/span>MOGAD\u306e\u4f55\u304c\u554f\u984c\u306a\u306e\u304b\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">MOGAD\u306e\u5834\u5408\u3001\u4f53\u5185\u306e\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u304c\u91cd\u5927\u306a\u9593\u9055\u3044\u3092\u72af\u3059\u3002 <strong>\u3053\u306e\u7d76\u7e01\u5c64\u306e\u5916\u5074\u306b\u3042\u308b\u7279\u5b9a\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u5bfe\u3059\u308b\u6297\u4f53<\/strong>, \u3044\u308f\u3086\u308b. <strong>MOG<\/strong>-\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b\u3002\u6297\u4f53\u306f\u5b9f\u969b\u306b\u306f\u3001\u30a6\u30a4\u30eb\u30b9\u3084\u7d30\u83cc\u306a\u3069\u306e\u75c5\u539f\u4f53\u3092\u8a8d\u8b58\u3057\u3001\u30de\u30fc\u30af\u3057\u3001\u7834\u58ca\u3059\u308b\u8eab\u4f53\u306e\u5b88\u8b77\u795e\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u3001MOGAD\u3067\u306f\u3001\u6297\u4f53\u304c\u8aa4\u3063\u3066\u4f53\u5185\u306e\u5065\u5eb7\u306a\u7d44\u7e54\u3001\u3064\u307e\u308a\u795e\u7d4c\u7dda\u7dad\u306e\u7d76\u7e01\u4f53\u306b\u5411\u3051\u3089\u308c\u3066\u3057\u307e\u3046\u306e\u3060\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30b1\u30fc\u30d6\u30eb\u306b\u4f8b\u3048\u308b\u3068\u3001\u7d76\u7e01\u4f53\u306b\u50b7\u3092\u3064\u3051\u305f\u308a\u3001\u524a\u3063\u305f\u308a\u3001\u8150\u98df\u3055\u305b\u305f\u308a\u3059\u308b\u3088\u3046\u306a\u3082\u306e\u3067\u3001\u7d76\u7e01\u4f53\u306b\u7a74\u304c\u958b\u304d\u3001\u96fb\u6c17\u4fe1\u53f7\u304c\u76ee\u7684\u5730\u306b\u304d\u308c\u3044\u306b\u5c4a\u304b\u306a\u304f\u306a\u3063\u305f\u308a\u3001\u307e\u3063\u305f\u304f\u5c4a\u304b\u306a\u304f\u306a\u3063\u305f\u308a\u3059\u308b\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wo_im_Korper_passiert_das\"><\/span>\u3053\u308c\u306f\u4f53\u306e\u3069\u3053\u3067\u8d77\u3053\u308b\u306e\u304b\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">MOGAD\u306f\u5c02\u3089\u3001\u6b21\u306e\u3053\u3068\u306b\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3002 <strong>\u4e2d\u67a2\u795e\u7d4c\u7cfb<\/strong>, \u3059\u306a\u308f\u3061\u3001\u8133\u3001\u810a\u9ac4\u3001\u8996\u795e\u7d4c\u3067\u3042\u308b\u3002\u3069\u306e\u90e8\u4f4d\u304c\u4fb5\u3055\u308c\u308b\u304b\u306b\u3088\u3063\u3066\u3001\u3055\u307e\u3056\u307e\u306a\u75c7\u72b6\u304c\u73fe\u308c\u308b\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8996\u795e\u7d4c<\/strong> - \u7a81\u7136\u306e\u8996\u529b\u4f4e\u4e0b\u3001\u304b\u3059\u307f\u76ee\u3001\u76ee\u306e\u75db\u307f\uff08\u7247\u76ee\u3060\u3051\u306e\u3053\u3068\u304c\u591a\u3044\u304c\u3001\u4e21\u76ee\u540c\u6642\u306b\u8d77\u3053\u308b\u3053\u3068\u3082\u3042\u308b\u3002\uff09<\/li>\n\n\n\n<li><strong>\u810a\u9ac4<\/strong> - \u9ebb\u75fa\u3001\u3057\u3073\u308c\u3001\u6392\u5c3f\u969c\u5bb3\u306a\u3069\u306e\u75c7\u72b6<\/li>\n\n\n\n<li><strong>\u8133\uff1a<\/strong> \u932f\u4e71\u3001\u3066\u3093\u304b\u3093\u767a\u4f5c\u3001\u5354\u8abf\u904b\u52d5\u969c\u5bb3<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wie_verlauft_die_Erkrankung\"><\/span>\u75c5\u6c17\u306f\u3069\u306e\u3088\u3046\u306b\u9032\u884c\u3059\u308b\u306e\u3067\u3059\u304b\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">MOGAD\u306f\u901a\u5e38\u3001\u6b21\u306e\u3088\u3046\u306a\u5f62\u3067\u9032\u884c\u3059\u308b\u3002 <strong>\u30d7\u30c3\u30b7\u30e5<\/strong>. .\u708e\u75c7\u304c\u6d3b\u767a\u3067\u75c7\u72b6\u304c\u51fa\u308b\u6642\u671f\u304c\u3042\u308a\u3001\u305d\u306e\u9593\u306b\u9759\u304b\u306a\u6642\u671f\u304c\u65ad\u7d9a\u7684\u306b\u3042\u308b\u3002.<br>\u767a\u75c7\u5f8c\u3001\u591a\u304f\u306e\u60a3\u8005\u306f\u9a5a\u304f\u307b\u3069\u3088\u304f\u56de\u5fa9\u3057\u3001\u4f8b\u3048\u3070MS\u3088\u308a\u3082\u3088\u304f\u306a\u308b\u3002\u3053\u308c\u306f\u3001\u795e\u7d4c\u7dda\u7dad\u305d\u306e\u3082\u306e\u304c\u3001\u90e8\u5206\u7684\u306b\u518d\u751f\u3059\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u7d76\u7e01\u5c64\u3088\u308a\u3082\u3001\u6c38\u4e45\u7684\u306a\u640d\u50b7\u3092\u53d7\u3051\u308b\u53ef\u80fd\u6027\u304c\u4f4e\u3044\u3053\u3068\u304c\u591a\u3044\u304b\u3089\u3067\u3042\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7f79\u60a3\u8005\u306e\u7d04\u534a\u6570\u306f\u3001\u751f\u6daf\u306b\u4e00\u5ea6\u3057\u304b\u518d\u71c3\u3092\u7d4c\u9a13\u3057\u306a\u3044\u3002\u6b8b\u308a\u306e\u534a\u6570\u306f\u518d\u767a\u3092\u7e70\u308a\u8fd4\u3057\u3001\u653e\u7f6e\u3059\u308c\u3070\u6c38\u4e45\u7684\u306a\u6a5f\u80fd\u969c\u5bb3\u306b\u3064\u306a\u304c\u308b\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wie_haufig_ist_MOGAD\"><\/span>MOGAD\u306f\u3069\u306e\u304f\u3089\u3044\u4e00\u822c\u7684\u306a\u306e\u3067\u3059\u304b\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">MOGAD\u306f\u307e\u308c\u3067\u3001\u63a8\u5b9a\u3055\u308c\u3066\u3044\u308b\u3060\u3051\u3067\u3042\u308b\u3002 <strong>10\u4e07\u4eba\u4e2d1-2\u4eba<\/strong> \u75c5\u6c17\u306b\u306a\u308b\u3002\u795e\u7d4c\u7cfb\u306e\u4ed6\u306e\u591a\u304f\u306e\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3068\u306f\u7570\u306a\u308a\u3001\u5973\u6027\u3068\u7537\u6027\u304c\u307b\u307c\u540c\u6570\u7f79\u60a3\u3059\u308b\u3002\u5b50\u4f9b\u3082\u767a\u75c7\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u3001\u591a\u304f\u306e\u5834\u5408\u3001\u932f\u4e71\u3068\u767a\u71b1\u3092\u4f34\u3046\u8133\u306e\u5e83\u7bc4\u306a\u708e\u75c7\u3068\u3057\u3066\u73fe\u308c\u308b\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Was_lost_MOGAD_aus\"><\/span>\u4f55\u304cMOGAD\u3092\u8a98\u767a\u3059\u308b\u306e\u304b\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u6700\u521d\u306e\u30a8\u30d4\u30bd\u30fc\u30c9\u306b\u7d9a\u304f\u3053\u3068\u304c\u591a\u3044\u3002 <strong>\u611f\u67d3\u75c7<\/strong> \u5148\u306b\u3002\u8eab\u4f53\u306f\u75c5\u539f\u4f53\u3068\u6226\u3044\u3001\u81ea\u5206\u306e\u8eab\u4f53\u306e\u69cb\u9020\u3092\u6575\u3068\u9593\u9055\u3048\u3066\u3057\u307e\u3046\u3002\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u306f\u3044\u308f\u3070\u9593\u9055\u3063\u305f\u6a19\u7684\u3092\u653b\u6483\u3059\u308b\u3053\u3068\u3092\u5b66\u7fd2\u3057\u3001\u6c7a\u3057\u3066\u6b62\u307e\u3089\u306a\u3044\u3002\u6b63\u78ba\u306a\u539f\u56e0\u306f\u307e\u3060\u5b8c\u5168\u306b\u306f\u89e3\u660e\u3055\u308c\u3066\u3044\u306a\u3044\u3002. <\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wie_wird_MOGAD_behandelt\"><\/span>MOGAD\u306e\u6cbb\u7642\u6cd5\u306f\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u73fe\u5728\u3001MOGAD\u306b\u5bfe\u3057\u3066\u7279\u306b\u8a8d\u53ef\u3055\u308c\u305f\u85ac\u306f\u306a\u3044\u3002\u3072\u3068\u3064\u306f <strong>\u6025\u6027\u767a\u4f5c<\/strong> \u3092\u5927\u91cf\u306b\u6295\u4e0e\u3059\u308b\u3002 <strong>\u30b3\u30eb\u30c1\u30be\u30f3\u8f38\u6db2<\/strong>, \u3053\u308c\u306f\u708e\u75c7\u3092\u7d20\u65e9\u304f\u93ae\u3081\u308b\u3002\u305d\u308c\u3067\u3082\u4e0d\u5341\u5206\u306a\u5834\u5408\u306f <strong>\u8840\u6db2\u6d17\u6d44<\/strong> (<em>\u30d7\u30e9\u30ba\u30de\u30d5\u30a7\u30ec\u30fc\u30b7\u30b9<\/em>)\u6709\u5bb3\u306a\u6297\u4f53\u3092\u8840\u6db2\u304b\u3089\u76f4\u63a5\u9664\u53bb\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u306b\u5bfe\u3057\u3066 <strong>\u518d\u767a\u4e88\u9632<\/strong> \u6297\u4f53\u7523\u751f\u7d30\u80de\u3092\u6e1b\u5c11\u3055\u305b\u308b\u7269\u8cea\u306a\u3069\u3001\u514d\u75ab\u7cfb\u3092\u843d\u3061\u7740\u304b\u305b\u308b\u305f\u3081\u306b\u69d8\u3005\u306a\u85ac\u5264\u304c\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u3002\u73fe\u5728\u3001\u3088\u308a\u6a19\u7684\u3092\u7d5e\u3063\u305f\u65b0\u85ac\u304c\u3044\u304f\u3064\u304b\u81e8\u5e8a\u8a66\u9a13\u4e2d\u3067\u3042\u308a\u3001\u4eca\u5f8c\u6570\u5e74\u3067\u8a8d\u53ef\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wissenschaftliche_Einleitung_und_Definition\"><\/span>\u79d1\u5b66\u7684\u306a\u5c0e\u5165\u3068\u5b9a\u7fa9<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">\u306b\u3064\u3044\u3066 <strong>MOG\u6297\u4f53\u95a2\u9023\u75be\u60a3\uff08MOGAD\uff09<\/strong> \u82f1\u8a9e\u3060\uff1a <em>\u30df\u30a8\u30ea\u30f3\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u6297\u4f53\u95a2\u9023\u75be\u60a3<\/em> \u306f\u3001\u4e2d\u67a2\u795e\u7d4c\u7cfb\uff08CNS\uff09\u306e\u307e\u308c\u306a\u708e\u75c7\u6027\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3067\u3042\u308a\u30012018\u5e74\u4ee5\u964d\u3001\u72ec\u81ea\u306e\u8a3a\u65ad\u57fa\u6e96\u3092\u6301\u3064\u72ec\u7acb\u3057\u305f\u75be\u60a3\u3068\u3057\u3066\u8a8d\u8b58\u3055\u308c\u3066\u3044\u308b\u3002\u4ee5\u524d\u306f\u591a\u767a\u6027\u786c\u5316\u75c7\uff08MS\uff09\u307e\u305f\u306f\u8996\u795e\u7d4c\u810a\u9ac4\u708e\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u969c\u5bb3\uff08NMOSD\uff09\u306e\u5909\u7a2e\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u305f\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u306b\u5bfe\u3059\u308b\u81ea\u5df1\u6297\u4f53\uff08IgG\uff09\u304c\u75c5\u7684\u306b\u7523\u751f\u3055\u308c\u308b\u3002 <strong>\u30df\u30a8\u30ea\u30f3\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\uff08MOG\uff09<\/strong>, \u306f\u3001\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306b\u5b58\u5728\u3059\u308b\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u306e\u30df\u30a8\u30ea\u30f3\u9798\u306e\u6700\u5916\u5c64\u306b\u3042\u308b\u819c\u8cab\u901a\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b\u3002\u3053\u308c\u3089\u306e\u6297\u4f53\u306f\u30df\u30a8\u30ea\u30f3\u9798\u3092\u50b7\u5bb3\u3057\u3001\u7279\u5fb4\u7684\u306a\u7d30\u80de\u5468\u56f2\u306e\u8131\u9ac4\u3092\u5f15\u304d\u8d77\u3053\u3059\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u81e8\u5e8a\u7684\u306b\u306f\u3001MOGAD\u306f\u4e3b\u306b\u8996\u795e\u7d4c\u708e\u3001\u6a2a\u65ad\u6027\u810a\u9ac4\u708e\u3001\u6025\u6027\u6563\u5728\u6027\u8133\u810a\u9ac4\u708e\uff08ADEM\uff09\u3068\u3057\u3066\u73fe\u308c\u308b\u3002\u3053\u306e\u75be\u60a3\u306f\u901a\u5e38\u518d\u767a\u6027\u3067\u3001\u8996\u795e\u7d4c\u3001\u810a\u9ac4\u3001\u307e\u308c\u306b\u8133\u3092\u4fb5\u3059\u3002\u767a\u75c7\u5e74\u9f62\u306e\u4e2d\u592e\u5024\u306f30\uff5e35\u6b73\u3067\u3001NMOSD\u3068\u306f\u5bfe\u7167\u7684\u306b\u3001\u5973\u6027\u3082\u7537\u6027\u3082\u307b\u307c\u540c\u3058\u983b\u5ea6\u3067\u7f79\u60a3\u3059\u308b\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Abgrenzung_von_MOGAD_NMOSD_und_MS\"><\/span>MOGAD\u3001NMOSD\u3001MS\u306e\u9451\u5225<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><td><strong>\u7279\u5fb4<\/strong><\/td><td><strong>\u30e2\u30ac\u30c9<\/strong><\/td><td><strong>AQP4+ NMOSD<\/strong><\/td><td><strong>\u591a\u767a\u6027\u786c\u5316\u75c7<\/strong><\/td><\/tr><\/thead><tbody><tr><td>\u6a19\u7684\u6297\u539f<\/td><td>MOG\uff08\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\uff09<\/td><td>\u30a2\u30af\u30a2\u30dd\u30ea\u30f3-4\uff08\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\uff09<\/td><td>\u7279\u7570\u7684\u81ea\u5df1\u6297\u4f53\u306a\u3057<\/td><\/tr><tr><td>\u6297\u4f53\u306e\u30a2\u30a4\u30bd\u30bf\u30a4\u30d7<\/td><td>IgG1\uff08\u524d\uff09<\/td><td>IgG1\uff08\u524d\uff09<\/td><td>\u30aa\u30ea\u30b4\u30af\u30ed\u30fc\u30ca\u30ebIgG\uff08CSF\uff09<\/td><\/tr><tr><td>\u4e00\u6b21\u7d30\u80de\u306e\u640d\u50b7<\/td><td>\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\uff0f\u30df\u30a8\u30ea\u30f3<\/td><td>\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\uff08\u4e00\u6b21\uff09<\/td><td>\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8<\/td><\/tr><tr><td>\u7d44\u7e54\u5b66<\/td><td>\u7d30\u80de\u5468\u56f2\u8131\u9ac4\u3001CD4+\uff08CD4+\u306e\u5834\u5408<\/td><td>\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u75c5\u5909\u3001\u9846\u7c92\u7403<\/td><td>\u8ef8\u5468\u56f2\u6591<\/td><\/tr><tr><td>\u6027\u5225\uff08\u7537\uff1a\u5973\uff09<\/td><td>~1:1<\/td><td>~9:1<\/td><td>~3:1<\/td><\/tr><tr><td>\u88dc\u4f53\u6d3b\u6027\u5316<\/td><td>\u4e2d\u7a0b\u5ea6\uff08MAC\u672a\u6e80\uff09<\/td><td>\u5f37\u529b\uff08MAC\u30d5\u30a9\u30fc\u30e1\u30fc\u30b7\u30e7\u30f3\uff09<\/td><td>\u4f4e\u3044<\/td><\/tr><tr><td>\u8133\u810a\u9ac4\u6db2\u4e2d\u306eOKB<\/td><td>\u307e\u308c (&lt;10%)<\/td><td>\u6642\u3005<\/td><td>\u983b\u7e41 (&gt;90%)<\/td><\/tr><tr><td>\u30b3\u30fc\u30b9<\/td><td>\u518d\u767a\u3092\u7e70\u308a\u8fd4\u3059\u3002<\/td><td>\u7a81\u304d\u51fa\u305f\u5f62\u3001\u969c\u5bb3\u3092\u84c4\u7a4d<\/td><td>\u3057\u3070\u3057\u3070\u5f37\u3044<\/td><\/tr><tr><td>\u8a8d\u5b9a\u7642\u6cd5<\/td><td>\u306a\u3057\uff082026\u5e74\u73fe\u5728\uff09<\/td><td>\u30a8\u30af\u30ea\u30ba\u30de\u30d6\u3001\u30a6\u30d6\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\u3001\u30b5\u30c8\u30e9\u30ea\u30ba\u30de\u30d6<\/td><td>\u591a\u304f\u306eDMT<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h1 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"MOG-Protein_%E2%80%93_Struktur_und_physiologische_Funktion\"><\/span>MOG\u30bf\u30f3\u30d1\u30af\u8cea - \u69cb\u9020\u3068\u751f\u7406\u6a5f\u80fd<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">MOG(\u30df\u30a8\u30ea\u30f3\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea)\u306f <strong>I\u578b\u819c\u8cab\u901a\u30bf\u30f3\u30d1\u30af\u8cea<\/strong> \u5168\u9577218\u30a2\u30df\u30ce\u9178\u3067\u3001\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306b\u306e\u307f\u767a\u73fe\u3057\u3066\u3044\u308b\u3002\u514d\u75ab\u30b0\u30ed\u30d6\u30ea\u30f3\u30b9\u30fc\u30d1\u30fc\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u4e00\u54e1\u3067\u3042\u308a\u3001\u30df\u30a8\u30ea\u30f3\u30bf\u30f3\u30d1\u30af\u8cea\u5168\u4f53\u306b\u5360\u3081\u308b\u5272\u5408\u306f0.01-0.05 %\u7a0b\u5ea6\u3067\u3001\u91cf\u7684\u306b\u306f\u5c11\u306a\u3044\u304c\u3001\u514d\u75ab\u5b66\u7684\u306b\u975e\u5e38\u306b\u91cd\u8981\u306a\u30df\u30a8\u30ea\u30f3\u9798\u306e\u69cb\u6210\u8981\u7d20\u3067\u3042\u308b\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Strukturdomanen\"><\/span>\u69cb\u9020\u30c9\u30e1\u30a4\u30f3<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7d30\u80de\u5916Ig-V\u69d8\u30c9\u30e1\u30a4\u30f3\uff08AS 1-120\uff09\uff1aMOG-IgG\u306e\u6700\u3082\u91cd\u8981\u306a\u30a8\u30d4\u30c8\u30fc\u30d7\u7d50\u5408\u90e8\u4f4d\u3067\u3042\u308bCC'\u30eb\u30fc\u30d7\u9818\u57df\uff08Pro42, His103, Ser104\uff09\u3092\u542b\u3080\u3002<\/li>\n\n\n\n<li>\u4e00\u91cd\u819c\u8cab\u901a\u3089\u305b\u3093\uff1a\u30df\u30a8\u30ea\u30f3\u819c\u306b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u56fa\u5b9a\u3059\u308b<\/li>\n\n\n\n<li>\u77ed\u3044\u7d30\u80de\u8ceaC\u672b\u7aef\u30c9\u30e1\u30a4\u30f3\uff1a\u7d30\u80de\u9aa8\u683c\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Physiologische_Funktionen\"><\/span>\u751f\u7406\u7684\u6a5f\u80fd<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u63a5\u7740\u5206\u5b50\uff1a\u30df\u30a8\u30ea\u30f3\u9798\u306e\u69cb\u9020\u7684\u5b8c\u5168\u6027\u3092\u5a92\u4ecb\u3057\u3001\u304a\u305d\u3089\u304f\u30df\u30a8\u30ea\u30f3\u30e9\u30e1\u30e9\u3092\u5727\u7e2e\u3059\u308b\u3002<\/li>\n\n\n\n<li>\u88dc\u4f53\u7cfb\u306eC1q\u3068\u306e\u76f8\u4e92\u4f5c\u7528\uff08\u751f\u7406\u5b66\u7684\uff09<\/li>\n\n\n\n<li>\u795e\u7d4c\u6210\u9577\u56e0\u5b50\uff08NGF\uff09\u3068\u306e\u76f8\u4e92\u4f5c\u7528<\/li>\n\n\n\n<li>\u98a8\u75b9\u30a6\u30a4\u30eb\u30b9\u53d7\u5bb9\u4f53\uff08\u611f\u67d3\u5f8cADEM\u306b\u81e8\u5e8a\u7684\u306b\u95a2\u9023\u3059\u308b\uff09<\/li>\n\n\n\n<li>\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u306b\u304a\u3051\u308b\u5fae\u5c0f\u7ba1\u306e\u5b89\u5b9a\u5316<\/li>\n\n\n\n<li>\u767a\u73fe\uff1a\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u5206\u5316\u306e\u5f8c\u671f\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">MOG-IgG\u81ea\u5df1\u6297\u4f53\u306f\u4e3b\u306b\u4ee5\u4e0b\u306e\u3082\u306e\u3092\u8a8d\u8b58\u3059\u308b\u3002 <strong>\u30b3\u30f3\u30d5\u30a9\u30e1\u30fc\u30b7\u30e7\u30f3\u30fb\u30a8\u30d4\u30c8\u30fc\u30d7<\/strong> \u7d30\u80de\u5916\u30c9\u30e1\u30a4\u30f3\u306eMOG\u306f\u30df\u30a8\u30ea\u30f3\u9798\u306e\u4e00\u756a\u5916\u5074\u306e\u8868\u9762\u306b\u9732\u51fa\u3057\u3066\u3044\u308b\u305f\u3081\u3001\u5faa\u74b0\u3057\u3066\u3044\u308b\u6297\u4f53\u3084\u514d\u75ab\u8907\u5408\u4f53\u306b\u76f4\u63a5\u30a2\u30af\u30bb\u30b9\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Pathogenese_und_Immunpathologie\"><\/span>\u75c5\u56e0\u3068\u514d\u75ab\u75c5\u7406\u5b66<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">MOGAD\u306e\u767a\u75c7\u306f\u3001\u672b\u68a2\u514d\u75ab\u306e\u6d3b\u6027\u5316\u3001\u8840\u6db2\u8133\u95a2\u9580\uff08BBB\uff09\u3092\u901a\u904e\u3059\u308b\u79fb\u52d5\u3001\u4e2d\u67a2\u795e\u7d4c\u7cfb\u5c40\u6240\u306e\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u6a5f\u69cb\u3092\u542b\u3080\u591a\u6bb5\u968e\u30d7\u30ed\u30bb\u30b9\u3067\u3042\u308b\u3002T\u7d30\u80de\u3082B\u7d30\u80de\u3082\u5358\u72ec\u3067\u306f\u5341\u5206\u306a\u75c5\u539f\u6027\u3092\u793a\u3055\u306a\u3044\u304c\u3001\u9069\u5fdc\u514d\u75ab\u7cfb\u306e\u4e21\u8005\u306e\u76f8\u4e57\u7684\u76f8\u4e92\u4f5c\u7528\u304c\u75c5\u6c17\u3092\u5f15\u304d\u8d77\u3053\u3059\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Trigger_und_initiale_Aktivierung\"><\/span>\u30c8\u30ea\u30ac\u30fc\u3068\u521d\u56de\u8d77\u52d5<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e3b\u306a\u521d\u671f\u8a98\u56e0\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3042\u308b\u3002 <strong>\u611f\u67d3\u75c7<\/strong> \u3092\u8b70\u8ad6\u3057\u305f\uff1aMOGAD\u60a3\u8005\u306e37-70 %\u306b\u611f\u67d3\u6027\u524d\u99c6\u75c7\u72b6\u304c\u8a8d\u3081\u3089\u308c\u3066\u3044\u308b\uff08NMOSD\u306e15-35 %\u3088\u308a\u3082\u983b\u5ea6\u304c\u9ad8\u3044\uff09\u3002\u305d\u306e\u6a5f\u5e8f\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3042\u308b\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5206\u5b50\u6a21\u5023 - \u75c5\u539f\u4f53\u306e\u30a8\u30d4\u30c8\u30fc\u30d7\u304cMOG\u306eCC'\u30eb\u30fc\u30d7\u9818\u57df\u3068\u69cb\u9020\u7684\u306b\u985e\u4f3c\u3057\u3066\u3044\u308b\u3002<\/li>\n\n\n\n<li>\u508d\u89b3\u8005\u306e\u6d3b\u6027\u5316 - \u975e\u7279\u7570\u7684\u708e\u75c7\u53cd\u5fdc\u306b\u3088\u308a\u3001\u4f11\u7720\u72b6\u614b\u306e\u81ea\u5df1\u53cd\u5fdc\u6027\u30ea\u30f3\u30d1\u7403\u304c\u6d3b\u6027\u5316\u3055\u308c\u308b\u3002<\/li>\n\n\n\n<li>\u5fae\u751f\u7269\u8d85\u6297\u539f\u306b\u3088\u308b\u30dd\u30ea\u30af\u30ed\u30fc\u30ca\u30ebB\u7d30\u80de\u6d3b\u6027\u5316<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u907a\u4f1d\u7684\u7d20\u56e0\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u304c\u3001\u7279\u5b9a\u306e\u30ea\u30b9\u30af\u30cf\u30d7\u30ed\u30bf\u30a4\u30d7\u306f\u6c7a\u5b9a\u7684\u306b\u7279\u5b9a\u3055\u308c\u3066\u3044\u306a\u3044\u3002MS\u3068\u306f\u5bfe\u7167\u7684\u306b\u3001\u4e00\u8cab\u3057\u305fHLA\u3068\u306e\u95a2\u9023\u306f\u5831\u544a\u3055\u308c\u3066\u3044\u306a\u3044\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"T-Zell-vermittelte_Pathogenese\"><\/span>T\u7d30\u80de\u3092\u4ecb\u3057\u305f\u75c5\u56e0<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">MOGAD\u306e\u767a\u75c7\u306b\u306fMOG\u7279\u7570\u7684CD4+ T\u7d30\u80de\u304c\u4e0d\u53ef\u6b20\u3067\u3042\u308b\u3002\u52d5\u7269\u30e2\u30c7\u30eb(EAE)\u3067\u306f\u3001\u6297\u4f53\u5358\u72ec\u3067\u306f\u75c5\u539f\u6027\u3092\u793a\u3055\u306a\u3044\uff1b\u5171\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u3068\u3057\u3066\u8133\u539f\u6027T\u7d30\u80de\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002CD4+\u7d4c\u8def\u306f\u3044\u304f\u3064\u304b\u306e\u6bb5\u968e\u304b\u3089\u306a\u308b\uff1a<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Phase_1_%E2%80%93_Periphere_Aktivierung\"><\/span>\u30d5\u30a7\u30fc\u30ba1 - \u672b\u68a2\u306e\u6d3b\u6027\u5316<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">MOG\u30da\u30d7\u30c1\u30c9\u306f\u3001\u6297\u539f\u63d0\u793a\u7d30\u80de(APC)\u306b\u3088\u3063\u3066\u3001\u4ee5\u4e0b\u306e\u7d4c\u8def\u3067\u7523\u751f\u3055\u308c\u308b\u3002 <strong>MHC-II\u5206\u5b50<\/strong> \u30ca\u30a4\u30fc\u30d6CD4+ T\u7d30\u80de\u306b\u5bfe\u3059\u308b\u6ce8\u76ee\u3059\u3079\u304d\u3053\u3068 <em>MOG\u30da\u30d7\u30c1\u30c9\u306f\u672b\u68a2\u306eMHC II\u5206\u5b50\u306b\u76f4\u63a5\u7d50\u5408\u3067\u304d\u308b<\/em>, \u3055\u3089\u306b\u51e6\u7406\u3059\u308b\u3053\u3068\u306a\u304f\u3002\u3053\u308c\u306f\u672b\u68a2\u795e\u7d4c\u7cfb\u306e\u95a2\u4e0e\u3092\u8aac\u660e\u3067\u304d\u308b\u3060\u308d\u3046\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e92\u3044\u306b\u72ec\u7acb\u3057\u3066EAE\u3092\u8a98\u5c0e\u3067\u304d\u308b\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u7d30\u80de\u30b5\u30d6\u30bb\u30c3\u30c8\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3042\u308b\u3002 <strong>Th1\u3001Th17\u3001Th9<\/strong>. .Th17\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08IL-17\u3001IL-21\uff09\u306f\u526a\u65ad\u30a8\u30d4\u30bd\u30fc\u30c9\u3067\u8457\u3057\u304f\u4e0a\u6607\u3059\u308b\u305f\u3081\u3001Th17\u7d30\u80de\u306fMOGAD\u306b\u7279\u306b\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Phase_2_%E2%80%93_BHS-Penetration\"><\/span>\u30d5\u30a7\u30fc\u30ba2 - BHS\u306e\u6d78\u900f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u6d3b\u6027\u5316CD4+ T\u7d30\u80de\u306f\u3001\u7279\u5b9a\u306e\u63a5\u7740\u5206\u5b50\uff08\u30a4\u30f3\u30c6\u30b0\u30ea\u30f3\u3001\u30bb\u30ec\u30af\u30c1\u30f3\uff09\u304a\u3088\u3073\u30b1\u30e2\u30ab\u30a4\u30f3\u53d7\u5bb9\u4f53\uff08\u7279\u306b <strong>CCR6<\/strong>)\u306b\u7d50\u5408\u3057\u3001\u4e2d\u67a2\u795e\u7d4c\u7cfb\u3078\u306e\u4fb5\u5165\u3092\u53ef\u80fd\u306b\u3059\u308b\u3002CCR6+ Th17\u7d30\u80de\u306f\u3001\u8108\u7d61\u53e2\u3067\u69cb\u6210\u7684\u306b\u767a\u73fe\u3057\u3066\u3044\u308bCCL20\u306b\u7d50\u5408\u3057\u3001\u305d\u308c\u3092\u4ecb\u3057\u3066\u30af\u30e2\u819c\u4e0b\u8154\u306b\u4fb5\u5165\u3059\u308b\u3002.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u30e1\u30bf\u30ed\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\uff08MMP-2\u3001MMP-9\uff09<br>BBB\u306e\u57fa\u5e95\u819c\u306e\u52a3\u5316<\/li>\n\n\n\n<li>\u597d\u4e2d\u7403NET\uff08\u597d\u4e2d\u7403\u7d30\u80de\u5916\u30c8\u30e9\u30c3\u30d7\uff09<br>\u30a4\u30cb\u30b7\u30a8\u30fc\u30b7\u30e7\u30f3\u671f\u306eT\u7d30\u80de\u306b\u30b3\u30b9\u30c6\u30a3\u30df\u30e5\u30ec\u30a4\u30c8\u30ea\u30fc\u30b7\u30b0\u30ca\u30eb\u3092\u4f9b\u7d66\u3059\u308b\u3002<\/li>\n\n\n\n<li>\u8840\u5c0f\u677f<br>\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3068\u63a5\u7740\u5206\u5b50\u3092\u901a\u3058\u3066\u3001CD4+ T\u7d30\u80de\u306e\u5897\u6b96\u3068Th1\/Th17\u3078\u306e\u5206\u5316\u3092\u4fc3\u9032\u3059\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Phase_3_%E2%80%93_Perivaskulare_Reaktivierung\"><\/span>\u30d5\u30a7\u30fc\u30ba3-\u8840\u7ba1\u5468\u56f2\u306e\u518d\u6d3b\u6027\u5316<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u8840\u7ba1\u5468\u56f2\u8154\u3068\u30af\u30e2\u819c\u4e0b\u8154\u3067\u306f\u3001MOG\u7279\u7570\u7684T\u7d30\u80de\u304cMOG\u3092\u8ca0\u8377\u3057\u305fAPC\uff08\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u3001\u6a39\u72b6\u7d30\u80de\uff09\u306b\u3088\u3063\u3066\u518d\u6d3b\u6027\u5316\u3055\u308c\u308b\u3002\u3053\u306e\u518d\u6d3b\u6027\u5316\u304c\u5b9f\u969b\u306e\u708e\u75c7\u30ab\u30b9\u30b1\u30fc\u30c9\u306e\u5f15\u304d\u91d1\u3068\u306a\u308b\uff1a\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u5206\u6ccc\u3001\u3055\u3089\u306a\u308b\u767d\u8840\u7403\u306e\u52d5\u54e1\u3001\u305d\u3057\u3066\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u306e\u640d\u50b7\u3067\u3042\u308b\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"B-Zell-_und_Antikorper-vermittelte_Pathogenese\"><\/span>B\u7d30\u80de\u304a\u3088\u3073\u6297\u4f53\u3092\u4ecb\u3057\u305f\u75c5\u56e0<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">MOG\u7279\u7570\u7684B\u7d30\u80de\u3068\u5f62\u8cea\u7d30\u80de\u306f\u3001\u75c5\u539f\u6027IgG1\u81ea\u5df1\u6297\u4f53\u306e\u4e3b\u306a\u7523\u751f\u7d30\u80de\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u3001B\u7d30\u80de\u306e\u5f79\u5272\u306f\u6297\u4f53\u7523\u751f\u306b\u3068\u3069\u307e\u3089\u306a\u3044\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6297\u539f\u63d0\u793a - B\u7d30\u80de\u306fBCR\u3092\u4ecb\u3057\u3066MOG\u306e\u30b3\u30f3\u30d5\u30a9\u30e1\u30fc\u30b7\u30e7\u30f3\u30a8\u30d4\u30c8\u30fc\u30d7\uff08CC'\u30eb\u30fc\u30d7\u306epro42\u3001his103\u3001ser104\uff09\u3068\u7d50\u5408\u3057\u3001T\u7d30\u80de\u306eAPC\u3068\u3057\u3066\u50cd\u304f\u3053\u3068\u304c\u3067\u304d\u308b\u3002<\/li>\n\n\n\n<li>Th17\u5206\u5316\u306e\u4fc3\u9032 - B\u7d30\u80de\u306fIL-6\u3092\u5206\u6ccc\u3057\u3001TGF-\u03b2\u3068\u3068\u3082\u306bTh17\u5206\u5316\u3092\u4fc3\u9032\u3059\u308b\u3002<\/li>\n\n\n\n<li>MAPK\u304a\u3088\u3073AKT\u30b7\u30b0\u30ca\u30eb\u306e\u6d3b\u6027\u5316 - BCR\u3068MOG\u306e\u7d50\u5408\u306b\u3088\u308a\u3001\u3053\u308c\u3089\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u304c\u7d30\u80de\u5185\u3067\u6d3b\u6027\u5316\u3055\u308c\u308b\u3002<\/li>\n\n\n\n<li>\u7d30\u80de\u5185\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u5897\u52a0 - \u30b9\u30c8\u30ec\u30b9\u95a2\u9023\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30ab\u30b9\u30b1\u30fc\u30c9\u306e\u6d3b\u6027\u5316\u306b\u3064\u306a\u304c\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u307b\u3068\u3093\u3069\u306eMOG-IgG\u6297\u4f53\u306f\u672b\u68a2\u3067\u7523\u751f\u3055\u308c\u308b\uff08\u9ac4\u6db2\u4e2d\u306e\u30aa\u30ea\u30b4\u30af\u30ed\u30fc\u30ca\u30eb\u30d0\u30f3\u30c9\u306f\u75c7\u4f8b\u306e\uff5e10 %\u306e\u307f\u3001MS\u306f\uff5e90 %\uff09\u3002\u6297\u4f53\u306f <strong>\u4e8c\u4fa1\u7d50\u5408<\/strong> \u3092MOG\u306b\u7d50\u5408\u3055\u305b\u308b\u3068\u3001\u4e21\u65b9\u306eFab\u30a2\u30fc\u30e0\u304c\u96a3\u63a5\u3059\u308b2\u3064\u306eMOG\u5206\u5b50\u306b\u540c\u6642\u306b\u7d50\u5408\u3059\u308b\u3002\u3053\u306e\u305f\u3081\u3001NMOSD\u306b\u304a\u3051\u308bAQP4-IgG\u306e\u4e00\u4fa1\u7d50\u5408\u3068\u6bd4\u8f03\u3057\u3066\u3001C1q\u306e\u30ea\u30af\u30eb\u30fc\u30c8\u52b9\u7387\u304c\u4f4e\u304f\u306a\u308b\u3002.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Molekulare_Signalwege_und_Effektormechanismen\"><\/span>\u5206\u5b50\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3068\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u6a5f\u69cb<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Signalweg_1_%E2%80%93_Klassischer_Komplementweg_CDC\"><\/span>\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def1 - \u53e4\u5178\u7684\u88dc\u4f53\u7d4c\u8def\uff08CDC\uff09<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">MOG-IgG1\uff08\u304a\u3088\u3073MOG-IgG3\uff09\u304c\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u306eMOG\u306b\u7d50\u5408\u3059\u308b\u3068\u3001\u4ee5\u4e0b\u306e\u3053\u3068\u304c\u8d77\u3053\u308b\u3002 <strong>\u30af\u30e9\u30b7\u30c3\u30af\u30fb\u30b3\u30f3\u30d7\u30ea\u30e1\u30f3\u30bf\u30eb\u30fb\u30eb\u30fc\u30c8<\/strong> \u304c\u6d3b\u6027\u5316\u3055\u308c\u308b\u3002\u3057\u304b\u3057\u3001MOGAD\u306b\u304a\u3051\u308b\u88dc\u4f53\u306e\u6d3b\u6027\u5316\u306fAQP4+ NMOSD\u3088\u308a\u3082\u5f31\u3044\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>C1q\u304c\u7d50\u5408\u3057\u305fIgG1\u6297\u4f53\u306eFc\u90e8\u5206\u306b\u7d50\u5408 \u2192 C1r\u3068C1s\u306e\u6d3b\u6027\u5316<\/li>\n\n\n\n<li>C4\u306e\u5207\u65ad \u2192 C4a + C4b; C4b + C2 \u2192 C3\u30b3\u30f3\u30d0\u30fc\u30bf\u30fc\u30bc\uff08C4b2a\uff09<\/li>\n\n\n\n<li>C3\u306e\u5207\u65ad\u2192C3a\uff08\u30a2\u30ca\u30d5\u30a3\u30e9\u30c8\u30ad\u30b7\u30f3\uff09\uff0bC3b\uff08\u30aa\u30d7\u30bd\u30cb\u30f3\uff09<\/li>\n\n\n\n<li>C3b\u2192C5\u30b3\u30f3\u30d0\u30fc\u30bf\u30fc\u30bc\u2192C5\u306e\u5207\u65ad\u2192C5a\uff08\u5f37\u529b\u306a\u30a2\u30ca\u30d5\u30a3\u30e9\u30c8\u30ad\u30b7\u30f3\uff09\uff0bC5b<\/li>\n\n\n\n<li>C5b\uff0bC6\u3001C7\u3001C8\u3001C9\u2192\u819c\u653b\u6483\u8907\u5408\u4f53\uff08MAC\u3001C5b-9\uff09\uff1a\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u306e\u76f4\u63a5\u6eb6\u89e3<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u91cd\u8981\uff1aMOGAD\u60a3\u8005\u306e\u9ac4\u6db2\u3067\u306f\u3001C3a\u3068C5a\u306f\u6709\u610f\u306b\u5897\u52a0\u3057\u3066\u3044\u308b\uff08AQP4+ NMOSD\u3068\u540c\u7a0b\u5ea6\uff09\u304c\u3001MAC\u8907\u5408\u4f53\uff08C5b-9\uff09\u306f\u6709\u610f\u306b\u5897\u52a0\u3057\u3066\u3044\u306a\u3044\u3002 <strong>\u8457\u3057\u304f\u4f4e\u3044<\/strong> NMOSD\u3088\u308a\u3082\u591a\u3044\u3002\u3053\u308c\u306f\u3001C1q\u30af\u30e9\u30b9\u30bf\u30ea\u30f3\u30b0\u306e\u52b9\u7387\u304c\u4f4e\u3044\u4e8c\u4fa1IgG\u7d50\u5408\u3068\u3001\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u4e0a\u306e\u88dc\u4f53\u5236\u5fa1\u56e0\u5b50\u306e\u5bc6\u5ea6\u304c\u6bd4\u8f03\u7684\u4f4e\u3044\uff08CR1\u3001MCP\u3001HRF\u304c\u4ed6\u306e\u7d30\u80de\u578b\u3088\u308a\u5c11\u306a\u3044\uff09\u3053\u3068\u306b\u3088\u308b\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Signalweg_2_%E2%80%93_Fc%CE%B3-Rezeptor-Weg_FcR-vermittelt\"><\/span>\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def2 - Fc\u03b3\u53d7\u5bb9\u4f53\u7d4c\u8def\uff08FcR\u3092\u4ecb\u3057\u305f\u7d4c\u8def\uff09<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">LMU\u306e\u7814\u7a76(Mader, Kawakami, Meinl, 2024 PNAS)\u306f\u3001Fc\u03b3\u53d7\u5bb9\u4f53(Fc\u03b3R)\u3092\u4ecb\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u3001Fc\u03b3R\u3092\u4ecb\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002 <strong>\u30df\u30a8\u30ea\u30f3\u640d\u50b7\u306e\u7d0450 %<\/strong> \u3057\u305f\u304c\u3063\u3066\u88dc\u4f53\u306e\u6d3b\u6027\u5316\u3068\u540c\u30ec\u30d9\u30eb\u3067\u3042\u308b\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Fc\u03b3RIII<\/strong> (<strong>CD16<\/strong>)\u306eNK\u7d30\u80de\u304a\u3088\u3073\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u5bfe\u3059\u308b\u4f5c\u7528<br>MOG\u7d50\u5408IgG1\u306eFc\u90e8\u5206\u3068\u7d50\u5408 \u2192 ADCC\uff08\u6297\u4f53\u4f9d\u5b58\u6027\u7d30\u80de\u50b7\u5bb3\u4f5c\u7528\uff09<\/li>\n\n\n\n<li><strong>Fc\u03b3RI\/II\/III<\/strong> \u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3068\u5358\u7403\u306b\u3064\u3044\u3066<br>MOG-\u30aa\u30d7\u30bd\u30cb\u30f3\u5316\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u65ad\u7247\u306e\u8caa\u98df\uff08ADCP\uff09<\/li>\n\n\n\n<li>\u6c7a\u5b9a\u7684\uff1a\u7b2c\u4e8c\u306eFcR\u30d1\u30b9\u30e1\u30ab\u30cb\u30ba\u30e0<br>\u88dc\u4f53\u7d4c\u8def\u3092\u4ecb\u3055\u305a\u3001Fc\u30ec\u30bb\u30d7\u30bf\u30fc\u306e\u307f\u3092\u4ecb\u3057\u3066T\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3092\u4fc3\u9032\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>Fc\u03b3R<\/strong> \u6a39\u72b6\u7d30\u80de\u306b\u3064\u3044\u3066<br>MOG-IgG\u3092\u8ca0\u8377\u3057\u305f\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u6297\u539f\u306e\u51e6\u7406\u3068MOG\u7279\u7570\u7684T\u7d30\u80de\u3078\u306e\u63d0\u793a\u3092\u4fc3\u9032\u3059\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u81e8\u5e8a\u7684\u610f\u5473\uff1a2\u3064\u306e\u72ec\u7acb\u3057\u305f\u767a\u75c7\u7d4c\u8def\u304c\u5b58\u5728\u3059\u308b\u305f\u3081\u3001\u6cbb\u7642\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u3082\u306e\u3067\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3002 <strong>\u3069\u3061\u3089\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3082<\/strong> \u6700\u5927\u9650\u306e\u52b9\u679c\u3092\u5f97\u308b\u305f\u3081\u306b\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Signalweg_3_%E2%80%93_IL-6JAK-STAT3-Weg\"><\/span>\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def3 - IL-6\/JAK-STAT3\u7d4c\u8def<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">IL-6\u306fMOGAD\u514d\u75ab\u75c5\u614b\u306e\u4e2d\u5fc3\u7684\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\u3067\u3042\u308a\u3001\u3044\u304f\u3064\u304b\u306e\u30ec\u30d9\u30eb\u3067\u4f5c\u7528\u3059\u308b\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">IL-6\u306f\u305d\u306e\u30ec\u30bb\u30d7\u30bf\u30fc\uff08IL-6R\u03b1\/gp130\u8907\u5408\u4f53\uff09\u306b\u7d50\u5408\u3059\u308b\u3002 <strong>JAK1\/2\u306e\u30ea\u30f3\u9178\u5316<\/strong> \u3092\u30ea\u30fc\u30c9\u3059\u308b\u3002\u3053\u308c\u306f\u4e3b\u306b\u4ee5\u4e0b\u3092\u6d3b\u6027\u5316\u3055\u305b\u308b\u3002 <strong>\u30b9\u30bf\u30c3\u30c8\u30b9\u30ea\u30fc<\/strong>, \u306e\u8ee2\u5199\u56e0\u5b50\u3068\u3057\u3066\u50cd\u304f\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Th17\u5206\u5316<\/strong><br>IL-6\uff0bTGF-\u03b2\u2192ROR\u03b3t\u767a\u73fe\u2192IL-17A\/F\u7523\u751f\uff1bIL-6\uff0bIL-23\u2192Th17\u8868\u73fe\u578b\u306e\u7dad\u6301<\/li>\n\n\n\n<li><strong>\u8449\u72b6T\u30d8\u30eb\u30d1\u30fc\u7d30\u80de<\/strong> (<strong>Tfh<\/strong>)<br>IL-6 \u2192 STAT3 \u2192 Bcl6\u306e\u767a\u73fe \u2192 \u80da\u4e2d\u5fc3B\u7d30\u80de\u306e\u6210\u719f\u3068IgG\u30af\u30e9\u30b9\u30b9\u30a4\u30c3\u30c1<\/li>\n\n\n\n<li><strong>B\u7d30\u80de\u304b\u3089\u5f62\u8cea\u7d30\u80de\u3078\u306e\u6210\u719f<\/strong><br>IL-6\u306fSTAT3\/Blimp-1\u8ef8\u3092\u4ecb\u3057\u3066\u5206\u5316\u3092\u4fc3\u9032\u3059\u308b<\/li>\n\n\n\n<li><strong>Treg\u6a5f\u80fd\u306e\u6291\u5236<\/strong><br>IL-6\u306fFoxP3\u306e\u767a\u73fe\u3092\u963b\u5bb3\u3057\u3001Treg\/Th17\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u708e\u75c7\u3078\u3068\u30b7\u30d5\u30c8\u3055\u305b\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u6cbb\u7642\u3068\u306e\u95a2\u9023IL-6\u906e\u65ad\u85ac\uff08\u30c8\u30b7\u30ea\u30ba\u30de\u30d6\u3001\u30b5\u30c8\u30e9\u30ea\u30ba\u30de\u30d6\u306a\u3069\uff09\u306f\u3053\u306e\u30b5\u30a4\u30af\u30eb\u3092\u65ad\u3061\u5207\u308b\u3002. <strong><em>\u30b5\u30c8\u30e9\u30ea\u30ba\u30de\u30d6<\/em><\/strong> (\u6297IL-6R\uff09\u306f\u73fe\u5728\u3001MOGAD\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7b2c3\u76f8METEOROID\u8a66\u9a13\u3067\u691c\u8a0e\u3055\u308c\u3066\u3044\u308b\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Signalweg_4_%E2%80%93_MAPK-_und_AKT-Signalwege_B-Zellen\"><\/span>\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def4 - MAPK\u304a\u3088\u3073AKT\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\uff08B\u7d30\u80de\uff09<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">B\u7d30\u80de\u3067\u6d3b\u6027\u5316\u3055\u308c\u308bMOG\u30b3\u30f3\u30d5\u30a9\u30e1\u30fc\u30b7\u30e7\u30f3\u30a8\u30d4\u30c8\u30fc\u30d7\u3078\u306eBCR\u7d50\u5408\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>MAPK\u30d1\u30b9<\/strong> (<strong>MEK\/ERK<\/strong>)<br>B\u7d30\u80de\u306e\u5897\u6b96\u3068\u5206\u5316\u306e\u4fc3\u9032<\/li>\n\n\n\n<li><strong>PI3K\/AKT\u30d1\u30b9<\/strong><br>\u7d30\u80de\u306e\u751f\u5b58\u3068B\u7d30\u80de\u304b\u3089\u5f62\u8cea\u7d30\u80de\u3078\u306e\u5206\u5316<\/li>\n\n\n\n<li><strong>\u30ab\u30eb\u30b7\u30a6\u30e0\u6d41\u5165<\/strong><br>\u30ab\u30eb\u30b7\u30cb\u30e5\u30fc\u30ea\u30f3\/NFAT\u8ef8\u306e\u6d3b\u6027\u5316\u2192\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u7523\u751f<\/li>\n\n\n\n<li><strong>NK\u7d30\u80de\u306e\u6d3b\u6027\u5316<\/strong><br>BCR-MOG\u7d50\u5408\u306fNK\u7d30\u80de\u3092\u4ecb\u3059\u308b\u7d30\u80de\u50b7\u5bb3\u6027\u3092\u8a98\u5c0e\u3059\u308b<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Signalweg_5_%E2%80%93_Th17-Zytokin-Netzwerk_im_ZNS\"><\/span>\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def5-\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306b\u304a\u3051\u308bTh17\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30cd\u30c3\u30c8\u30ef\u30fc\u30af<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e2d\u67a2\u795e\u7d4c\u7cfb\u3067\u306f\u3001Th17\u7d30\u80de\u306f\u8907\u6570\u306e\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\u3092\u901a\u3058\u3066\u708e\u75c7\u74b0\u5883\u3092\u7dad\u6301\u3057\u3066\u3044\u308b\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>IL-17A\u3068IL-17F<\/strong><br>\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3068\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u3092\u6d3b\u6027\u5316\u3059\u308b\u3002\u597d\u4e2d\u7403\u3092\u30ea\u30af\u30eb\u30fc\u30c8\u3059\u308b\u30b1\u30e2\u30ab\u30a4\u30f3\uff08CXCL-1\/5\/8\uff09\u306e\u653e\u51fa\u3092\u8a98\u5c0e\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>IL-21<\/strong> (\u30aa\u30fc\u30c8\u304a\u3088\u3073\u30d1\u30e9\u30af\u30ea\u30f3\uff09<br>Th17\u5206\u5316\u3092\u4fc3\u9032\u3059\u308b\uff1bB\u7d30\u80de\u5206\u5316\u3068IgG\u30af\u30e9\u30b9\u30b9\u30a4\u30c3\u30c1\uff08\u7279\u306bIgG1\uff09\u3092\u4fc3\u9032\u3059\u308b<\/li>\n\n\n\n<li><strong>IL-22<\/strong><br>BBB\u306e\u5b8c\u5168\u6027\u306e\u8abf\u7bc0\u969c\u5bb3<\/li>\n\n\n\n<li><strong>GM-CSF<\/strong> (<strong>IL-23\u7d4c\u7531<\/strong>)<br>\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u3068\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3092\u6d3b\u6027\u5316\u3057\u3001\u5c40\u6240\u7684\u306a\u8131\u9ac4\u3092\u4fc3\u9032\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>CXCL13<\/strong><br>\u8840\u7ba1\u5468\u56f2\u8154\u306b\u304a\u3051\u308bB\u7d30\u80de\u306e\u8d70\u5316\u6027 \u2192 \u5c40\u6240\u6297\u4f53\u7523\u751f<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Signalwege_%E2%80%93_Ubersicht\"><\/span>\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def - \u6982\u8981<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><td><strong>\u4fe1\u53f7\u7d4c\u8def<\/strong><\/td><td><strong>\u4e3b\u8981\u5206\u5b50<\/strong><\/td><td><strong>\u52b9\u679c<\/strong><\/td><td><strong>\u6cbb\u7642\u30bf\u30fc\u30b2\u30c3\u30c8<\/strong><\/td><\/tr><\/thead><tbody><tr><td>\u30af\u30e9\u30b7\u30c3\u30af\u306a\u88dc\u5b8c\u30eb\u30fc\u30c8<\/td><td>C1q\u3001C3\u3001C5\u3001MAC\uff08C5b-9\uff09<\/td><td>\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u306e\u76f4\u63a5\u6eb6\u89e3<\/td><td>C5\u963b\u5bb3\u85ac\uff08\u30a8\u30af\u30ea\u30ba\u30de\u30d6\uff09\u3001C3\u963b\u5bb3\u85ac<\/td><\/tr><tr><td>Fc\u03b3R\u30d1\u30b9\uff08ADCC\/ADCP\uff09<\/td><td>Fc\u03b3RI\/II\/III\u3001NK\u7d30\u80de\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8<\/td><td>\u7d30\u80de\u6bd2\u6027\u3001\u8caa\u98df\u3001T\u7d30\u80de\u5897\u5f37<\/td><td>FcRn\u963b\u5bb3\u5264\uff08IgG\u5206\u89e3\uff09\u3001FcR\u906e\u65ad\u5264<\/td><\/tr><tr><td>IL-6\/JAK-STAT3<\/td><td>IL-6\u3001IL-6R\u03b1\u3001gp130\u3001JAK1\/2\u3001STAT3\u3001ROR\u03b3t<\/td><td>Th17\u5206\u5316\u3001B\u7d30\u80de\u6210\u719f\u3001IgG\u7523\u751f<\/td><td>\u6297IL-6R\u85ac\uff08\u30c8\u30b7\u30ea\u30ba\u30de\u30d6\u3001\u30b5\u30c8\u30e9\u30ea\u30ba\u30de\u30d6\uff09<\/td><\/tr><tr><td>PI3K\/ACT\/MAPK\uff08B\u7d30\u80de\uff09<\/td><td>BTK\u3001PI3K\u3001ACT\u3001ERK\u3001NFAT<\/td><td>B\u7d30\u80de\u6d3b\u6027\u5316\u3001\u5f62\u8cea\u7d30\u80de\u6210\u719f<\/td><td>BTK\u963b\u5bb3\u5264\uff08\u30a4\u30d6\u30eb\u30c1\u30cb\u30d6\u3001\u30c8\u30ec\u30d6\u30eb\u30c1\u30cb\u30d6\uff09<\/td><\/tr><tr><td>Th17\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30cd\u30c3\u30c8\u30ef\u30fc\u30af<\/td><td>IL-17\u3001IL-21\u3001IL-22\u3001GM-CSF\u3001CXCL13<\/td><td>BBB\u306e\u640d\u50b7\u3001\u767d\u8840\u7403\u306e\u52d5\u54e1\u3001\u8131\u9ac4<\/td><td>\u6297IL-17\u3001\u6297IL-21<\/td><\/tr><tr><td>FcRn-IgG\u306e\u30ea\u30b5\u30a4\u30af\u30eb<\/td><td>FcRn\uff08\u65b0\u751f\u5150Fc\u30ec\u30bb\u30d7\u30bf\u30fc\uff09<\/td><td>IgG\u534a\u6e1b\u671f\u306e\u5ef6\u9577<\/td><td>\u6297FcRn\uff08\u30ed\u30b6\u30ce\u30ea\u30ad\u30b7\u30ba\u30de\u30d6\uff09<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h1 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Relevante_Rezeptoren_und_Zielmolekule\"><\/span>\u95a2\u9023\u53d7\u5bb9\u4f53\u3068\u6a19\u7684\u5206\u5b50<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"MOG_selbst_als_Zielstruktur_kein_klassischer_Rezeptor\"><\/span>\u6a19\u7684\u69cb\u9020\u3068\u3057\u3066\u306eMOG\u305d\u306e\u3082\u306e\uff08\u53e4\u5178\u7684\u306a\u53d7\u5bb9\u4f53\u3067\u306f\u306a\u3044\uff09<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">MOGAD\u3067\u306f\u3001MOG\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u53d7\u5bb9\u4f53\u3068\u3057\u3066\u3067\u306f\u306a\u304f\u3001\u6297\u539f\u3068\u3057\u3066\u50cd\u304f\u3002\u305d\u308c\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u4ee5\u4e0b\u306e\u76f8\u4e92\u4f5c\u7528\u306f\u75c5\u614b\u751f\u7406\u5b66\u7684\u306b\u91cd\u8981\u3067\u3042\u308b\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>C1q\u7d50\u5408<\/strong><br>MOG\u306f\u751f\u7406\u7684\u306bC1q\u3068\u7d50\u5408\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u3001\u3053\u308c\u304c\u75c5\u7684\u306a\u6297\u4f53\u88ab\u8986\u306e\u5834\u5408\u306b\u306f\u88dc\u4f53\u306e\u6d3b\u6027\u5316\u306b\u3064\u306a\u304c\u308b\u3002<\/li>\n\n\n\n<li><strong>DC\u30b5\u30a4\u30f3 (cd209)<\/strong><br>\u6a39\u72b6\u7d30\u80de\u4e0a\u306e\u30ec\u30af\u30c1\u30f3\u53d7\u5bb9\u4f53\u3002MOG\u3068\u7d50\u5408\u3057\u3001\u6297\u539f\u63d0\u793a\u306b\u5bc4\u4e0e\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u98a8\u75b9\u30a6\u30a4\u30eb\u30b9\u53d7\u5bb9\u4f53<\/strong>_<br>MOG\u306f\u98a8\u75b9\u30a6\u30a4\u30eb\u30b9\u306e\u4fb5\u5165\u5206\u5b50\u3067\u3042\u308a\u3001\u5c0f\u5150\u306e\u611f\u67d3\u5f8cADEM\u3092\u8aac\u660e\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Fc%CE%B3-Rezeptoren_Fc%CE%B3R\"><\/span>Fc\u03b3\u53d7\u5bb9\u4f53\uff08Fc\u03b3R\uff09<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u514d\u75ab\u7d30\u80de\u4e0a\u306eFc\u03b3\u30ec\u30bb\u30d7\u30bf\u30fc\u306f\u3001IgG1\u3092\u4ecb\u3057\u305f\u30c0\u30e1\u30fc\u30b8\u306e\u4e2d\u5fc3\u7684\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u3067\u3042\u308b\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Fc\u03b3RI (CD64)<\/strong><br>\u9ad8\u89aa\u548c\u6027\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u304a\u3088\u3073\u6a39\u72b6\u7d30\u80de\u4e0a\uff1bADCP\u304a\u3088\u3073\u6297\u539f\u63d0\u793a\u306e\u4ef2\u4ecb<\/li>\n\n\n\n<li><strong>Fc\u03b3RIII (CD16)<\/strong><br>\u4f4e\u89aa\u548c\u6027\u3001NK\u7d30\u80de\u4e0a\uff1bMOG\u30aa\u30d7\u30bd\u30cb\u30f3\u5316\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u306b\u5bfe\u3059\u308bADCC\u306e\u4e3b\u8981\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc<\/li>\n\n\n\n<li><strong>Fc\u03b3RIIA\/B (CD32A\/B)<\/strong><br>\u6d3b\u6027\u5316\u307e\u305f\u306f\u6291\u5236\uff1bB\u7d30\u80de\u6d3b\u6027\u5316\u304a\u3088\u3073\u8caa\u98df\u306e\u8abf\u7bc0<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Neonataler_Fc-Rezeptor_FcRn\"><\/span>\u65b0\u751f\u5150Fc\u53d7\u5bb9\u4f53\uff08FcRn\uff09<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">FcRn\uff08\u03b22m\/FcRn-\u03b1\u8907\u5408\u4f53\uff09\u306fIgG\u6297\u4f53\u306e\u7d30\u80de\u5185\u30ea\u30b5\u30a4\u30af\u30eb\u3092\u62c5\u3063\u3066\u3044\u308b\u3002\u9178\u6027\u5316\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\uff08pH6.0\uff09\u3067IgG\u3068\u7d50\u5408\u3057\u3001\u30ea\u30bd\u30bd\u30fc\u30e0\u3067\u306e\u5206\u89e3\u3092\u963b\u6b62\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001IgG\u306e\u534a\u6e1b\u671f\u3092\u7d0421\u65e5\u307e\u3067\u5ef6\u9577\u3059\u308b\u3002.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>MOGAD\u3067\u306f\u3001FcRn\u304c\u75c5\u539f\u6027MOG-IgG1\u306e\u6301\u7d9a\u7684\u306a\u5faa\u74b0\u3092\u5f15\u304d\u8d77\u3053\u3059\u3002<\/li>\n\n\n\n<li>\u306b\u3088\u308b\u6cbb\u7642\u59a8\u5bb3 <em>\u30ed\u30b6\u30ce\u30ea\u30ad\u30b7\u30ba\u30de\u30d6<\/em> (\u6297FcRn IgG4\uff09\uff1a\u30ea\u30bd\u30bd\u30fc\u30e0\u3067\u306eIgG\u5206\u89e3\u3092\u5f37\u5236\u3057\u3001\u8840\u6f3f\u4e2dIgG\u3092\uff5e50%\u4f4e\u4e0b\u3055\u305b\u308b\u3002<\/li>\n\n\n\n<li>FcRn\u767a\u73fe-\u4e0a\u76ae\u7d30\u80de\u3001\u5185\u76ae\u7d30\u80de\u3001\u5358\u7403\u3001\u809d\u7d30\u80de<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"IL-6-Rezeptor_IL-6R%CE%B1_gp130\"><\/span>IL-6\u53d7\u5bb9\u4f53 (IL-6R\u03b1 \/ gp130)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">IL-6\u30ec\u30bb\u30d7\u30bf\u30fc\u306f\u30ea\u30ac\u30f3\u30c9\u7d50\u5408\u03b1\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\uff08IL-6R\u03b1\u3001CD126\uff09\u3068\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u5171\u53d7\u5bb9\u4f53gp130\uff08IL-6R\u03b2\u3001CD130\uff09\u304b\u3089\u306a\u308b\u3002\u4e8c\u3064\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u69d8\u5f0f\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30af\u30e9\u30b7\u30c3\u30af\u30fb\u30b7\u30b0\u30ca\u30eb<\/strong><br>T\u7d30\u80de\u3001B\u7d30\u80de\u3001\u5358\u7403\u4e0a\u306e\u819c\u7d50\u5408\u578bIL-6R\u03b1\u2192IL-6\/IL-6R\u03b1\/gp130\u8907\u5408\u4f53\u2192JAK1\/2\u2192STAT3\u3001STAT1\u3001MAPK\u3001PI3K\/AKT<\/li>\n\n\n\n<li><strong>\u30c8\u30e9\u30f3\u30b9\u30b7\u30b0\u30ca\u30eb<\/strong><br>\u53ef\u6eb6\u6027IL-6R\u03b1\uff08sIL-6R\uff09\u306fIL-6\u3068\u7d50\u5408\u3057\u3001\u819c\u7d50\u5408\u578bIL-6R\u03b1\u3092\u6301\u305f\u306a\u3044\u7d30\u80de\uff08BBB\u306e\u5185\u76ae\u7d30\u80de\u306a\u3069\uff09\u3067\u3082gp130\u3092\u6d3b\u6027\u5316\u3059\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u95a2\u9023\u3059\u308b\u4e0b\u6d41\u52b9\u679c\uff1aROR\u03b3t\u767a\u73fe\uff08Th17\uff09\u3001Bcl-6\uff08Tfh\u304a\u3088\u3073\u80da\u4e2d\u5fc3\uff09\u3001Blimp-1\uff08\u5f62\u8cea\u7d30\u80de\uff09\u3001FoxP3\u306e\u6291\u5236\uff08Treg\uff09\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"T-Zell-Rezeptor_TCR_und_Kostimulationsmolekule\"><\/span>T\u7d30\u80de\u53d7\u5bb9\u4f53\uff08TCR\uff09\u3068\u30b3\u30b9\u30c8\u523a\u6fc0\u5206\u5b50<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>TCR\/MHC-II-MOG\u30da\u30d7\u30c1\u30c9\u8907\u5408\u4f53<\/strong><br>MOG\u7279\u7570\u7684CD4+ T\u7d30\u80de\u306e\u4e2d\u5fc3\u7684\u6d3b\u6027\u5316\u8ef8<\/li>\n\n\n\n<li><strong>CD28\/B7<\/strong><br>T\u7d30\u80de\u6d3b\u6027\u5316\u306b\u304a\u3051\u308b\u30b3\u30b9\u30c8\u523a\u6fc0<\/li>\n\n\n\n<li><strong>CCR6\/CCL20\u8ef8<\/strong><br>Th17\u7d30\u80de\u4e0a\u306eCCR6\u304c\u8108\u7d61\u53e2\u3067CCL20\u3068\u7d50\u5408\u2192\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306b\u4fb5\u5165<\/li>\n\n\n\n<li><strong>CXCR3\/CXCL10<\/strong><br>\u708e\u75c7\u9818\u57df\u306b\u304a\u3051\u308bTh1\u7d30\u80de\u306e\u8d70\u5316\u6027<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Komplementrezeptoren\"><\/span>\u88dc\u4f53\u53d7\u5bb9\u4f53<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>C1qR<\/strong><br>\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u819c\u4e0a\u306e\u514d\u75ab\u8907\u5408\u4f53\u3068C1q\u306e\u7d50\u5408\u3092\u5a92\u4ecb\u3059\u308b<\/li>\n\n\n\n<li><strong>C3aR <\/strong>\u305d\u3057\u3066<strong> C5aR1 (CD88)<\/strong><br>\u30df\u30af\u30ed\u30b0\u30ea\u30a2\uff0f\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u4e0a\u306e\u30a2\u30ca\u30d5\u30a3\u30e9\u30c8\u30ad\u30b7\u30f3\u53d7\u5bb9\u4f53 \u2192 \u708e\u75c7\u4fc3\u9032\u6d3b\u6027\u5316<\/li>\n\n\n\n<li><strong>\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u306e\u88dc\u4f53\u5236\u5fa1\u56e0\u5b50<\/strong><br>CR1(CD35)\u3001MCP(CD46)\u3001HRF(CD59)\u306f\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u3067\u306f\u767a\u73fe\u304c\u4f4e\u304f\u3001\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3088\u308a\u3082\u88dc\u4f53\u306b\u3088\u308b\u640d\u50b7\u3092\u53d7\u3051\u3084\u3059\u3044\u3002<\/li>\n<\/ul>\n\n\n\n<h1 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Histopathologie_und_ZNS-Lasionsmuster\"><\/span>\u75c5\u7406\u7d44\u7e54\u5b66\u304a\u3088\u3073\u4e2d\u67a2\u795e\u7d4c\u7cfb\u75c5\u5909\u30d1\u30bf\u30fc\u30f3<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">MOGAD\u75c5\u5909\u306f\u3001\u75c5\u7406\u7d44\u7e54\u5b66\u7684\u306bMS\u3084NMOSD\u3068\u306f\u6839\u672c\u7684\u306b\u7570\u306a\u3063\u3066\u3044\u308b\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9759\u8108\u6027\u8131\u9ac4<\/strong><br>\u75c5\u5909\u306f\u5c0f\u3055\u306a\u9759\u8108\u306e\u5468\u56f2\u306b\u96c6\u4e2d\u7684\u306b\u5f62\u6210\u3055\u308c\u308b\uff08\u9759\u8108\u5468\u56f2\u30d1\u30bf\u30fc\u30f3\uff09\u3002MS\u306e\u5178\u578b\u7684\u306a\u300c\u4e2d\u5fc3\u9759\u8108\u5fb4\u5019\u300d\u306fMRI\u3067\u306f\u8a8d\u3081\u3089\u308c\u306a\u3044\u3002<\/li>\n\n\n\n<li><strong>CD4\uff0b T\u7d30\u80de\u6d78\u6f64<\/strong><br>\u512a\u52e2\u306a\u708e\u75c7\u7d30\u80de\u30d1\u30bf\u30fc\u30f3\u306fCD4+ T\u7d30\u80de\u3068\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3067\u3001\u597d\u4e2d\u7403\u306f\u5c11\u306a\u304f\u3001\u597d\u9178\u7403\u9846\u7c92\u7403\u306f\u307b\u3068\u3093\u3069\u306a\u3044\uff08AQP4+ NMOSD\u3068\u306f\u7570\u306a\u308b\uff09\u3002<\/li>\n\n\n\n<li><strong>\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u306e\u640d\u50b7<\/strong> (\u4e00\u6b21)<br>\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u304c\u4e3b\u306b\u640d\u50b7\u3092\u53d7\u3051\u308bNMOSD\u3068\u306f\u5bfe\u7167\u7684\u306b\u3001MOGAD\u306f\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u306e\u5909\u6027\u3092\u7279\u5fb4\u3068\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>C9\u30cd\u30aa\u6c88\u6bbf<\/strong><br>NMOSD\u3088\u308a\u5f31\u3044\u3082\u306e\u306e\u3001\u75c5\u5909\u90e8\u3067MAC\uff08\u7d42\u672b\u88dc\u4f53\u8907\u5408\u4f53\uff09\u304c\u691c\u51fa\u3055\u308c\u308b\u3002<\/li>\n\n\n\n<li><strong>\u76f8\u5bfe\u7684\u306a\u8ef8\u7d22\u4fdd\u5b58<\/strong><br>\u6025\u6027\u767a\u4f5c\u3067\u306f\u3001\u8ef8\u7d22\u306e\u640d\u50b7\u306fMS\u3088\u308a\u3082\u8efd\u5fae\u3067\u3042\u308b\u3053\u3068\u304c\u591a\u304f\u3001\u3053\u306e\u3053\u3068\u304c\u3057\u3070\u3057\u3070\u826f\u597d\u306a\u81e8\u5e8a\u7684\u56de\u5fa9\u3092\u3082\u305f\u3089\u3059\u3002<\/li>\n\n\n\n<li><strong>\u76ae\u8cea\u75c5\u5909<\/strong><br>\u9ac4\u819c\u708e\u304a\u3088\u3073\u76ae\u8cea\u8131\u9ac4\uff08ADEM\u578b\u306b\u591a\u3044\uff09<\/li>\n<\/ul>\n\n\n\n<h1 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Klinische_Manifestationen_und_Phanotypen\"><\/span>\u81e8\u5e8a\u75c7\u72b6\u3068\u8868\u73fe\u578b<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">MOGAD\u306f\u81e8\u5e8a\u7684\u306b\u4e0d\u5747\u4e00\u3067\u3042\u308b\u3002\u91cd\u8981\u306a\u8868\u73fe\u578b<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><td><strong>\u8868\u73fe\u578b<\/strong><\/td><td><strong>\u983b\u5ea6<\/strong><\/td><td><strong>\u81e8\u5e8a\u7684\u7279\u5fb4<\/strong><\/td><td><strong>MRI\u5c02\u9580\u5206\u91ce<\/strong><\/td><\/tr><\/thead><tbody><tr><td>\u8996\u795e\u7d4c\u708e\uff08ON\uff09<\/td><td>\u6700\u3082\u4e00\u822c\u7684\uff08\u7d0450%\uff09<\/td><td>\u3057\u3070\u3057\u3070\u4e21\u5074\u6027\u3001\u8996\u529b\u4f4e\u4e0b\u3001\u5f8c\u773c\u623f\u3001\u75db\u307f\u3092\u4f34\u3046\u773c\u7403\u904b\u52d5\u3002\u773c\u7403\u904b\u52d5<\/td><td>\u9577\u3044\u8996\u795e\u7d4c\u75c5\u5909\u3001\u795e\u7d4c\u5468\u56f2\u9020\u5f71\u5264\u96c6\u7a4d<\/td><\/tr><tr><td>\u6a2a\u65ad\u6027\u810a\u9ac4\u708e<\/td><td>\u7d0430%<\/td><td>\u7e26\u65ad\u6027\u810a\u9ac4\u708e\uff08LETM\uff09\u3001\u611f\u899a\/\u904b\u52d5\u3001\u8180\u80f1\u969c\u5bb3<\/td><td>\u7e26\u578bT2\u75c5\u5909\u3001H2\u75c7\u5019\u7fa4\uff08\u300c\u30ec\u30f3\u30ba\u72b6\u300d\uff09\u3002<\/td><\/tr><tr><td>\u6025\u6027\u6563\u5728\u6027\u8133\u810a\u9ac4\u708e<\/td><td>\u5c0f\u5150\u306b\u591a\u3044\u75c7\u72b6<\/td><td>\u8133\u75c7\u3001\u591a\u5de3\u6027\u795e\u7d4c\u969c\u5bb3\u6b20\u640d<\/td><td>\u4e21\u5074\u3001\u5927\u5bb9\u7a4d\u306eT2\u75c5\u5909\u3001\u5927\u8133\u57fa\u5e95\u6838\u306b\u3082\u767a\u751f<\/td><\/tr><tr><td>\u8133\u5e79\u8133\u708e<\/td><td>\u7d0415%<\/td><td>\u8907\u8996\u3001\u904b\u52d5\u5931\u8abf\u3001\u5f8c\u9762\u9818\u57df\u75c7\u5019\u7fa4\uff08\u3057\u3083\u3063\u304f\u308a\u3001\u5614\u5410\uff09<\/td><td>\u8133\u5e79\uff0f\u5c0f\u8133T2\u75c5\u5909<\/td><\/tr><tr><td>\u76ae\u8cea\u8133\u708e<\/td><td>\u3088\u308a\u5e0c\u5c11<\/td><td>\u3066\u3093\u304b\u3093\u767a\u4f5c\u3001\u932f\u4e71<\/td><td>\u76ae\u8ceaFLAIR\u4fe1\u53f7\u306e\u5909\u5316<\/td><\/tr><tr><td>\u30af\u30ea\u30aa\u30f3<\/td><td>\u3088\u308a\u5e0c\u5c11<\/td><td>\u6162\u6027\u518d\u767a\u6027\u708e\u75c7\u8996\u795e\u7d4c\u969c\u5bb3<\/td><td>\u6301\u7d9a\u7684\u306a\u8996\u795e\u7d4c\u640d\u50b7<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h1 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Diagnostik\"><\/span>\u8a3a\u65ad<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">\u8a3a\u65ad\u57fa\u6e96\uff08Banwell et al\u3001, <em>\u30e9\u30f3\u30bb\u30c3\u30c8\u795e\u7d4c\u5b66<\/em> 2023\u5e74\uff09\u304c\u5fc5\u8981\u3067\u3042\u308b\uff1a <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">(1) \u30bb\u30eb\u30d9\u30fc\u30b9\u30a2\u30c3\u30bb\u30a4\uff08CBA\uff09\u3092\u7528\u3044\u305f\u8840\u6e05\u307e\u305f\u306f\u8133\u810a\u9ac4\u6db2\u4e2d\u306eMOG-IgG\u306e\u691c\u51fa<br>(2) \u9069\u5207\u306a\u81e8\u5e8a\u8868\u73fe\u578b<br>(3) \u4ee3\u66ff\u8a3a\u65ad\u306e\u9664\u5916\u3002.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7d30\u80de\u30d9\u30fc\u30b9\u306e\u514d\u75ab\u86cd\u5149\u691c\u67fb\uff08CBA\uff09<\/strong><br>\u5929\u7136\u306b\u6298\u308a\u7573\u307e\u308c\u305f\u819c\u7d50\u5408\u578bMOG\uff08\u30d2\u30c8MOG\u3092\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30c8\u3057\u305fHEK293\u7d30\u80de\uff09\u3092\u7528\u3044\u3066\u3001\u7acb\u4f53\u69cb\u9020\u306b\u4f9d\u5b58\u3057\u305f\u30a8\u30d4\u30c8\u30fc\u30d7\u3092\u691c\u51fa\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>ELISA\u304a\u3088\u3073\u30e9\u30a4\u30f3\uff0f\u30b9\u30c8\u30ea\u30c3\u30d7\u30fb\u30d6\u30ed\u30c3\u30c8<\/strong><br>\u76f4\u9396\u30a8\u30d4\u30c8\u30fc\u30d7\u304c\u8a8d\u8b58\u3055\u308c\u308b\u305f\u3081\u3001MOGAD\u306e\u4fe1\u983c\u6027\u306f\u4f4e\u3044<\/li>\n\n\n\n<li><strong>IgG\u30b5\u30d6\u30af\u30e9\u30b9<\/strong><br>\u4e3b\u306bIgG1\u3001\u6642\u306bIgG2\u3001IgG3\u3001IgG4\u3002\u6392\u4ed6\u7684IgG3\u967d\u6027\u306f\u8a3a\u65ad\u306e\u843d\u3068\u3057\u7a74\u3067\u3042\u308b\uff08Jarius 2024\uff09\u3002<\/li>\n\n\n\n<li><strong>\u6ef4\u5b9a\u30ad\u30cd\u30c6\u30a3\u30af\u30b9<\/strong><br>\u9ad8\u529b\u4fa1\u306e\u6301\u7d9a\u306f\u518d\u767a\u30ea\u30b9\u30af\u3068\u76f8\u95a2\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u9152\u985e<\/strong><br>\u8840\u7403\u6e1b\u5c11\u306e\u53ef\u80fd\u6027\uff1b\u30aa\u30ea\u30b4\u30af\u30ed\u30fc\u30ca\u30eb\u30d0\u30f3\u30c9\u306f\u307e\u308c\uff08&lt;10 %\uff09\u3001IgG\u306e\u9ac4\u8154\u5185\u5408\u6210\u306f\u307e\u308c\u3002<\/li>\n\n\n\n<li><strong>\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc<\/strong><br>\u75be\u60a3\u6d3b\u52d5\u6027\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u306esNfL\uff08\u8840\u6e05\u30cb\u30e5\u30fc\u30ed\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u8efd\u9396\uff09\uff1b\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u75c5\u5909\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u306esGFAP\uff08\u30b0\u30ea\u30a2\u7dda\u7dad\u9178\u6027\u30bf\u30f3\u30d1\u30af\u8cea<\/li>\n<\/ul>\n\n\n\n<h1 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Therapeutische_Strategien\"><\/span>\u6cbb\u7642\u6226\u7565<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Akuttherapie_Schubbehandlung\"><\/span>\u6025\u6027\u671f\u6cbb\u7642\uff08\u518d\u767a\u6cbb\u7642\uff09<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">MOGAD\u518d\u767a\u306e\u6a19\u6e96\u6cbb\u7642\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9ad8\u7528\u91cf <em>\u30e1\u30c1\u30eb\u30d7\u30ec\u30c9\u30cb\u30be\u30ed\u30f3<\/em> (HDMP)<\/strong><br>1000mg\u30921\u65e51\u56de\u70b9\u6ef4\u9759\u6ce8\u30015\u65e5\u9593 - \u30d5\u30a1\u30fc\u30b9\u30c8\u30e9\u30a4\u30f3<\/li>\n\n\n\n<li><em><strong>\u30d7\u30e9\u30ba\u30de\u30d5\u30a7\u30ec\u30fc\u30b7\u30b9\uff0f\u514d\u75ab\u5438\u7740<\/strong><\/em><br>HDMP\u306e\u52b9\u679c\u304c\u4e0d\u5341\u5206\u306a\u5834\u5408\uff1b\u8840\u6f3f\u304b\u3089MOG-IgG\u3092\u9664\u53bb\u3059\u308b\uff1b5-7\u30b5\u30a4\u30af\u30eb\uff08\u30ec\u30c8\u30ed\u30b9\u30da\u30af\u30c6\u30a3\u30d6\u306a\u30c7\u30fc\u30bf\u3067\u306f\u3001\u7d0450-70%\u306e\u75c7\u4f8b\u3067\u6709\u52b9\u6027\u3092\u793a\u3059\uff09<\/li>\n\n\n\n<li><strong><em>\u514d\u75ab\u30b0\u30ed\u30d6\u30ea\u30f3\u9759\u8108\u6ce8\u5c04<\/em> (IVIG\uff09<\/strong><br>2g\/kg\u30925\u65e5\u9593\u304b\u3051\u3066\u6295\u4e0e\uff1bHDMP\u306b\u53cd\u5fdc\u3057\u306a\u3044\u5834\u5408\u3001\u304a\u3088\u3073\u30d7\u30e9\u30b9\u30de\u30d5\u30a7\u30ec\u30fc\u30b7\u30b9\u5f8c\u306e\u30aa\u30d7\u30b7\u30e7\u30f3\u3068\u3057\u3066\uff1bFcRn\u98fd\u548c\u304a\u3088\u3073Fc\u03b3R\u7af6\u5408\u3092\u4ecb\u3057\u3066\u6709\u52b9\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u30b3\u30eb\u30c1\u30b3\u30b9\u30c6\u30ed\u30a4\u30c9\u306e\u6f38\u6e1b<\/strong><br>MOGAD\uff08\u983b\u56de\u306e\u30b9\u30c6\u30ed\u30a4\u30c9\u4f9d\u5b58\u75c7\uff09\u306b\u304a\u3044\u3066\u7279\u306b\u91cd\u8981 - \u6025\u6fc0\u306a\u6e1b\u91cf\u306f\u30ea\u30d0\u30a6\u30f3\u30c9\u30a8\u30d4\u30bd\u30fc\u30c9\u306e\u5f15\u304d\u91d1\u3068\u306a\u308a\u3046\u308b<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Prophylaktische_Langzeittherapie\"><\/span>\u4e88\u9632\u7684\u9577\u671f\u7642\u6cd5<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">(\u9069\u5fdc\u5916\u3001\u627f\u8a8d\u3055\u308c\u305f\u88fd\u5264\u306a\u3057 - 2026\u5e74\uff09\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u9577\u671f\u6cbb\u7642\u306e\u9069\u5fdc\u306f\u500b\u5225\u7684\u3067\u3042\u308a\u3001\u3059\u3079\u3066\u306e\u60a3\u8005\u306b\u9577\u671f\u6cbb\u7642\u304c\u5fc5\u8981\u306a\u308f\u3051\u3067\u306f\u306a\u3044\u3002\u8981\u56e0\uff1a\u518d\u767a\u7387\u3001\u518d\u767a\u306e\u91cd\u75c7\u5ea6\u3001MOG-IgG\u4fa1\u306e\u6301\u7d9a\u3001\u8868\u73fe\u578b\u306e\u5371\u967a\u56e0\u5b50\u3002.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><td><strong>\u7269\u8cea<\/strong><\/td><td><strong>\u4f5c\u7528\u30e1\u30ab\u30cb\u30ba\u30e0<\/strong><\/td><td><strong>\u30c7\u30fc\u30bf\u72b6\u6cc1<\/strong><\/td><td><strong>\u8a3c\u62e0\u30ec\u30d9\u30eb<\/strong><\/td><\/tr><\/thead><tbody><tr><td>\u30a2\u30b6\u30c1\u30aa\u30d7\u30ea\u30f3<\/td><td>\u30d7\u30ea\u30f3\u5408\u6210\u963b\u5bb3\uff08TPMT\u4f9d\u5b58\u6027\uff09\uff1bT\u7d30\u80de\u304a\u3088\u3073B\u7d30\u80de\u306e\u5897\u6b96\u3092\u963b\u5bb3\u3059\u308b\u3002<\/td><td>\u30ec\u30c8\u30ed\u30b9\u30da\u30af\u30c6\u30a3\u30d6\u7814\u7a76\uff1b\u56fd\u5185RCT\u5b9f\u65bd\u4e2d\uff08\u30d5\u30e9\u30f3\u30b9\u3001TOMATO\u7814\u7a76\uff09<\/td><td>IIb-III\uff08\u9069\u5fdc\u5916\uff09<\/td><\/tr><tr><td>\u30df\u30b3\u30d5\u30a7\u30ce\u30fc\u30eb\u9178\u30e2\u30d5\u30a7\u30c1\u30eb\uff08MMF\uff09<\/td><td>\u30a4\u30ce\u30b7\u30f3\u4e00\u30ea\u30f3\u9178\u30c7\u30d2\u30c9\u30ed\u30b2\u30ca\u30fc\u30bc\u963b\u5bb3\u5264\uff1b\u30ea\u30f3\u30d1\u7403\u5897\u6b96\u6291\u5236\u4f5c\u7528<\/td><td>\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\u3088\u308a\u518d\u767a\u4e88\u9632\u52b9\u679c\u306f\u4f4e\u3044\u3002<\/td><td>III\uff08\u9069\u5fdc\u5916\uff09<\/td><\/tr><tr><td>\u30ea\u30c4\u30ad\u30b7\u30de\u30d6<\/td><td>\u6297CD20 \u2192 B\u7d30\u80de\u67af\u6e07\uff1bMOG-IgG\u7523\u751f\u6291\u5236<\/td><td>\u6700\u5927\u898f\u6a21\u306e\u30ec\u30c8\u30ed\u30b9\u30da\u30af\u30c6\u30a3\u30d6\u30b3\u30db\u30fc\u30c8\uff1b\u52b9\u679c\u7684\u3067\u306f\u3042\u308b\u304c\u3001\u3059\u3079\u3066\u306e\u4eba\u306b\u6709\u52b9\u3068\u306f\u9650\u3089\u306a\u3044\uff1b\u611f\u67d3\u30ea\u30b9\u30af\u306e\u5897\u52a0<\/td><td>IIb\uff08\u9069\u5fdc\u5916\uff09<\/td><\/tr><tr><td>\u30c8\u30b7\u30ea\u30ba\u30de\u30d6<\/td><td>\u6297IL-6R\u03b1\uff08iv\uff09\uff1aIL-6\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\uff08JAK\/STAT3\uff09\u3092\u906e\u65ad\u3057\u3001Th17\/\u5f62\u8cea\u7d30\u80de\u3092\u6291\u5236\u3059\u308b\u3002<\/td><td>\u80af\u5b9a\u7684\u306a\u30ec\u30c8\u30ed\u30b9\u30da\u30af\u30c6\u30a3\u30d6\u30c7\u30fc\u30bf\uff1bNMOSD\u306eRCT\u7d50\u679c\u306f\u80af\u5b9a\u7684\uff08TANGO\uff09<\/td><td>IIb\uff08\u9069\u5fdc\u5916\uff09<\/td><\/tr><tr><td>IVIG\uff08\u9759\u8108\u5185\/\u76ae\u4e0b\uff09<\/td><td>Fc\u53d7\u5bb9\u4f53\u98fd\u548c\u5ea6\uff1bMOG-IgG\u4e2d\u548c\uff1bFcRn\u98fd\u548c\u5ea6<\/td><td>\u30ec\u30c8\u30ed\u30b9\u30da\u30af\u30c6\u30a3\u30d6\u306a\u30c7\u30fc\u30bf\u306f\u80af\u5b9a\u7684\u3067\u3042\u308b\u3002<\/td><td>IIb\uff08\u9069\u5fdc\u5916\uff09<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Klinische_Studien_%E2%80%93_2024%E2%80%932026\"><\/span>\u81e8\u5e8a\u8a66\u9a13 - 2024-2026<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u521d\u3081\u3066\u3001MOGAD\u306b\u3064\u3044\u3066\u3044\u304f\u3064\u304b\u306e\u7121\u4f5c\u70ba\u5316\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u7b2c3\u76f8\u8a66\u9a13\u304c\u9032\u884c\u4e2d\u3067\u3042\u308a\u3001\u30af\u30e9\u30b9I\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u5f97\u3089\u308c\u308b\u3068\u671f\u5f85\u3055\u308c\u3066\u3044\u308b\uff1a<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><td><strong>\u7814\u7a76<\/strong><\/td><td><strong>\u7269\u8cea<\/strong><\/td><td><strong>\u30e1\u30ab\u30cb\u30ba\u30e0<\/strong><\/td><td><strong>\u5bfe\u8c61\u8005<\/strong><\/td><td><strong>\u30b9\u30c6\u30fc\u30bf\u30b9<\/strong><\/td><\/tr><\/thead><tbody><tr><td>\u30b3\u30b9\u30e2\u30c3\u30b0<\/td><td>\u30ed\u30b6\u30ce\u30ea\u30ad\u30b7\u30ba\u30de\u30d6\uff08UCB7665\uff09<\/td><td>\u6297FcRn IgG4-mAb\uff1aIgG\u306e\u30ea\u30b5\u30a4\u30af\u30eb\u3092\u963b\u5bb3\u2192IgG\u306e\u5206\u89e3\u3092\u4fc3\u9032\u3001MOG IgG\u529b\u4fa1\u3092\u4f4e\u4e0b \uff5e50 %<\/td><td>\u6210\u4eba\uff0818\u6b73\u4ee5\u4e0a\uff09\u3001\u518d\u767a\u6027\u30011\u56de\u4ee5\u4e0a\u306e\u518d\u767a\/12\u30f5\u6708\u4ee5\u4e0a<\/td><td>\u30d5\u30a7\u30fc\u30ba3\u3001\u56fd\u969b\u5171\u540c\uff1b\u53f2\u4e0a\u521d\u306eMOGAD\u30d5\u30a7\u30fc\u30ba3\u8a66\u9a13<\/td><\/tr><tr><td>\u30e1\u30c6\u30aa\u30ed\u30a4\u30c9<\/td><td>\u30b5\u30c8\u30e9\u30ea\u30ba\u30de\u30d6\uff08\u6297IL-6R sc.\uff09<\/td><td>\u6297IL-6R\uff08\u76ae\u4e0b\uff09\uff1bJAK\/STAT3\u3092\u963b\u5bb3 \u2192 Th17\u5206\u5316\u3001B\u7d30\u80de\u6210\u719f\u3001IgG\u7523\u751f<\/td><td>\u6210\u4eba\uff0b\u9752\u5e74\uff0812\u6b73\u4ee5\u4e0a\uff09\uff1b\u518d\u767a\u6027\u3067\u3001\u305d\u306e\u524d\u306b1\u56de\u4ee5\u4e0a\u306e\u518d\u767a\u304c\u3042\u308b\u3002<\/td><td>\u30d5\u30a7\u30fc\u30ba3\u3001\u56fd\u969b\u3001\u7d99\u7d9a\u4e2d<\/td><\/tr><tr><td>TOMATO<\/td><td>\u30a2\u30b6\u30c1\u30aa\u30d7\u30ea\u30f3<\/td><td>\u30d7\u30ea\u30f3\u5408\u6210\u963b\u5bb3\uff1b\u5e83\u7bc4\u306a\u514d\u75ab\u6291\u5236\u4f5c\u7528<\/td><td>\u30d5\u30e9\u30f3\u30b9\u306e\u591a\u65bd\u8a2d\u5171\u540c\u7814\u7a76\uff1b\u6210\u4ebaMOGAD\u60a3\u8005<\/td><td>\u7b2c3\u76f8\u5168\u56fdRCT<\/td><\/tr><tr><td>MOGwAI<\/td><td>\u7279\u5b9a\u305b\u305a\uff08\u89b3\u5bdf\u7684\uff09<\/td><td>\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u7814\u7a76\uff1a\u9032\u884c\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u306eMOG-IgG\u529b\u4fa1\u3001sNfL\u3001sGFAP\u3001sCD83\u306e\u691c\u8a3c<\/td><td>\u56fd\u969b\u30b3\u30db\u30fc\u30c8\u7814\u7a76<\/td><td>\u7d99\u7d9a\u4e2d<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Neue_und_zukunftige_Therapiekonzepte\"><\/span>\u65b0\u3057\u3044\u3001\u305d\u3057\u3066\u672a\u6765\u306e\u6cbb\u7642\u30b3\u30f3\u30bb\u30d7\u30c8<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd1\u5e74\u306e\u5206\u5b50\u751f\u7269\u5b66\u7684\u77e5\u898b\u306b\u57fa\u3065\u304d\u3001MOGAD\u306b\u5bfe\u3059\u308b\u4ee5\u4e0b\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u8b70\u8ad6\u3055\u308c\u3066\u3044\u308b\uff1a<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"BTK-Inhibitoren_Bruton-Tyrosin-Kinase\"><\/span>BTK\u963b\u5bb3\u5264\uff08\u30d6\u30eb\u30c8\u30f3\u578b\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\uff09<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">BTK\u306fB\u7d30\u80de\u53d7\u5bb9\u4f53\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30ab\u30b9\u30b1\u30fc\u30c9\uff08PI3K\/ACT\/MAPK\uff09\u306e\u4e2d\u5fc3\u7684\u30ad\u30ca\u30fc\u30bc\u3067\u3042\u308b\u3002. <strong><em>\u30c8\u30ec\u30d6\u30eb\u30c1\u30cb\u30d6<\/em><\/strong> \u306a\u3069\u306eBTK\u963b\u5bb3\u5264\u304cMS\u3084NMOSD\u306e\u7814\u7a76\u6bb5\u968e\u306b\u3042\u308a\u3001MOGAD\u306b\u3064\u3044\u3066\u306f\u81e8\u5e8a\u8a66\u9a13\u4e2d\u3067\u3042\u308b\u3002MOGAD\u306f\u81e8\u5e8a\u8a66\u9a13\u4e2d\u3002B\u7d30\u80de\u6d3b\u6027\u5316\u3068\u30df\u30a8\u30ed\u30a4\u30c9\u7d30\u80de\uff08\u30df\u30af\u30ed\u30b0\u30ea\u30a2-BTK\uff09\u306e\u4e21\u65b9\u3092\u963b\u5bb3\u3059\u308b\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Toleranzinduktion_MOG-Tolerisierung\"><\/span>\u5bdb\u5bb9\u8a98\u5c0e\uff08MOG\u5bdb\u5bb9\u5316\uff09<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u6297\u539f\u7279\u7570\u7684\u5bdb\u5bb9\u8a98\u5c0e\uff08MOG\u30da\u30d7\u30c1\u30c9\u3084\u30ca\u30ce\u7c92\u5b50\u3092\u7528\u3044\u305f\u30a2\u30d7\u30ed\u30fc\u30c1\u306a\u3069\uff09\u306f\u6709\u671b\u306a\u30b3\u30f3\u30bb\u30d7\u30c8\u3067\u3042\u308b\u3002\u305d\u306e <strong><em>\u30ac\u30c6\u30a3\u30fb\u30b8\u30e3\u30af\u30bd\u30f3\u6148\u5584\u8ca1\u56e3<\/em><\/strong> \u6cbb\u7642\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\u306e\u7814\u7a76\u3092\u4fc3\u9032\u3059\u308b\u3002\u5229\u70b9\uff1a\u4e16\u754c\u7684\u306a\u514d\u75ab\u6291\u5236\u304c\u306a\u3044\u3001, <strong>MOG\u81ea\u5df1\u53cd\u5fdc\u6027\u306e\u9078\u629e\u7684\u9664\u53bb<\/strong>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Komplementinhibitoren\"><\/span>\u88dc\u4f53\u963b\u5bb3\u5264<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u88dc\u4f53\u306e\u6d3b\u6027\u5316\uff08C3a\u3001C5a\u3001MAC\uff09\u306fMOGAD\u75c5\u5909\u3067\u691c\u51fa\u53ef\u80fd\u3067\u3042\u308b\u3053\u3068\u304b\u3089\u3001\u6b21\u306e\u3053\u3068\u304c\u8003\u3048\u3089\u308c\u308b\u3002 <strong><em>\u30a8\u30af\u30ea\u30ba\u30de\u30d6<\/em> (\u6297C5)<\/strong> \u307e\u305f\u306fC3\u963b\u5bb3\u5264\u304c\u7406\u8ad6\u7684\u306b\u306f\u6709\u52b9\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u3001MAC\u8907\u5408\u4f53\uff08C5b-9\uff09\u304c\u5f62\u6210\u3055\u308c\u308b\u7a0b\u5ea6\u306f\u3001NMOSD\u3088\u308a\u3082MOGAD\u306e\u65b9\u304c\u306f\u308b\u304b\u306b\u4f4e\u3044\u306e\u3067\uff08\u3053\u3053\u3067 <em>\u30a8\u30af\u30ea\u30ba\u30de\u30d6<\/em> \u304c\u8a8d\u53ef\u3055\u308c\u3066\u3044\u308b\uff09\u3001\u81e8\u5e8a\u7684\u95a2\u9023\u6027\u306f\u4e0d\u660e\u3067\u3042\u308b\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Anti-Neonatal-Fc-Rezeptor-Strategien\"><\/span>\u6297\u65b0\u751f\u5150Fc\u30ec\u30bb\u30d7\u30bf\u30fc\u6226\u7565<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u4ed6 <em>\u30ed\u30b6\u30ce\u30ea\u30ad\u30b7\u30ba\u30de\u30d6<\/em> \u307e\u305f <strong><em>\u30a8\u30d5\u30ac\u30eb\u30c1\u30ae\u30e2\u30c9<\/em><\/strong> (FcRn\u3092\u7af6\u5408\u7684\u306b\u906e\u65ad\u3059\u308bIgG-Fc\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\uff09\u3092\u3001\u4ed6\u306eIgG\u4ecb\u5728\u6027\u75be\u60a3\u306b\u7528\u3044\u308b\u3002FcRn\u906e\u65ad\u306e\u75c5\u614b\u30e1\u30ab\u30cb\u30ba\u30e0\u306fMOG-IgG\u30ec\u30d9\u30eb\u3092\u76f4\u63a5\u4f4e\u4e0b\u3055\u305b\u308b\u306e\u3067\u3001\u3053\u308c\u306f\u7279\u306b\u6a19\u7684\u6307\u5411\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u3042\u308b\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Autologe_hamatopoetische_Stammzelltransplantation_aHSCT\"><\/span>\u81ea\u5bb6\u9020\u8840\u5e79\u7d30\u80de\u79fb\u690d\uff08aHSCT\uff09<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u91cd\u7be4\u306a\u96e3\u6cbb\u6027\u306e\u75c7\u4f8b\u306b\u5bfe\u3057\u3066\u306f\u3001\u9020\u8840\u5e79\u7d30\u80de\u79fb\u690d\u304c\u6cbb\u7652\u306e\u53ef\u80fd\u6027\u306e\u3042\u308b\u6cbb\u7642\u6cd5\u3067\u3042\u308b\uff1a\u6df1\u3044\u514d\u75ab\u5207\u9664\u3068\u514d\u75ab\u7cfb\u306e\u518d\u69cb\u7bc9\u306b\u3088\u308a\u3001\u81ea\u5df1\u53cd\u5fdc\u6027T\u7d30\u80de\u3068B\u7d30\u80de\u306e\u30af\u30ed\u30fc\u30f3\u3092\u6392\u9664\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002MOGAD\u306b\u95a2\u3059\u308b\u30c7\u30fc\u30bf\u306f\u975e\u5e38\u306b\u9650\u3089\u308c\u3066\u3044\u308b\u3002.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Biomarker_und_Verlaufsmonitoring\"><\/span>\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u8ffd\u8de1\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306b\u57fa\u3065\u304f\u6cbb\u7642\u6cd5\u306e\u6c7a\u5b9a\u306f\u3001\u73fe\u5728\u306e\u7814\u7a76\u306e\u76ee\u6a19\u3067\u3042\u308b\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>MOG-IgG\u529b\u4fa1\uff08\u8840\u6e05\uff09<\/strong><br>\u6301\u7d9a\u6027\u306f\u518d\u767a\u30ea\u30b9\u30af\u3068\u76f8\u95a2\u3059\u308b\uff1b\u5358\u76f8\u6027\u30b3\u30fc\u30b9\u306e\u5834\u5408\u3001\u3057\u3070\u3057\u3070\u529b\u4fa1\u306f\u81ea\u7136\u306b\u4f4e\u4e0b\u3059\u308b\uff1b\u6cbb\u7642\u6cd5\u306e\u6c7a\u5b9a\u306f\u5171\u540c\u6c7a\u5b9a\u56e0\u5b50\u3068\u306a\u308b<\/li>\n\n\n\n<li><strong>\u8840\u6e05\u30cb\u30e5\u30fc\u30ed\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u30e9\u30a4\u30c8\uff08sNfL\uff09<\/strong><br>\u8ef8\u7d22\u640d\u50b7\u306e\u30de\u30fc\u30ab\u30fc\uff1b\u518d\u767a\u6642\u306b\u4e0a\u6607\uff1b\u6cbb\u7642\u53cd\u5fdc\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u6b63\u5e38\u5316<\/li>\n\n\n\n<li><strong>\u8840\u6e05GFAP\uff08sGFAP\uff09<\/strong><br>\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306e\u6d3b\u6027\u5316\uff1bMOGAD\u3067\u306fNMOSD\u3088\u308a\u4f4e\u3044\uff1b\u88dc\u5b8c\u7684\u306a\u60c5\u5831\u3092\u63d0\u4f9b\u3067\u304d\u308b\u3002<\/li>\n\n\n\n<li><strong>sCD83<\/strong><br>\u65b0\u305f\u306a\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u5019\u88dc\uff08\u691c\u8a3c\u4e2d\uff09\uff1b\u6a39\u72b6\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3068\u514d\u75ab\u6d3b\u6027\u306e\u30de\u30fc\u30ab\u30fc\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u8133\u810a\u9ac4\u6db2\u306e\u7d30\u80de\u6570\u3068\u86cb\u767d\u8cea<\/strong><br>\u7a81\u767a\u6027\u767a\u75b9\u6642\u306e\u8840\u5c0f\u677f\u5897\u591a\uff1b\u6cbb\u7642\u5f8c\u6b63\u5e38\u5316<\/li>\n<\/ul>\n\n\n\n<h1 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Prognose_und_Besonderheiten\"><\/span>\u4e88\u60f3\u3068\u7279\u96c6<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">AQP4+\u306eNMOSD\u3068\u6bd4\u8f03\u3059\u308b\u3068\u3001MOGAD\u306f\u6b21\u306e\u3088\u3046\u306a\u50be\u5411\u304c\u3042\u308b\u3002 <strong>\u3088\u308a\u597d\u307e\u3057\u3044\u4e88\u60f3<\/strong>, \u7279\u306bON\u5f8c\u306e\u8996\u529b\u56de\u5fa9\u304c\u826f\u3044\u3002\u3057\u304b\u3057\u3001\u4ee5\u4e0b\u306e\u70b9\u304c\u91cd\u8981\u3067\u3042\u308b\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5358\u76f8\u9032\u884c<\/strong><br>\u60a3\u8005\u306e\u7d0450%\uff1b\u591a\u304f\u306e\u5834\u5408\u3001\u529b\u4fa1\u306f\u81ea\u7136\u306b\u4f4e\u4e0b\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u30b9\u30e9\u30b9\u30c8\u578b\u306e\u9032\u884c<\/strong><br>\u7d0450%\uff1b\u3088\u308a\u9ad8\u3044\u529b\u4fa1\u304c\u6301\u7d9a\uff1b\u7d2f\u7a4d\u969c\u5bb3\u84c4\u7a4d\u306e\u53ef\u80fd\u6027\u304c\u3042\u308b\u304c\u3001NMOSD\u3088\u308a\u9045\u3044\u3002<\/li>\n\n\n\n<li><strong>\u30d7\u30ed\u30b0\u30ec\u30c3\u30b7\u30d6\u30b3\u30fc\u30b9\u306a\u3057<\/strong><br>MS\u3068\u306f\u5bfe\u7167\u7684\u306b\u3001\u518d\u767a\u3092\u4f34\u308f\u306a\u3044\u7de9\u3084\u304b\u306a\u9032\u884c\u306f\u5831\u544a\u3055\u308c\u3066\u3044\u306a\u3044\u3002<\/li>\n\n\n\n<li><strong>\u30b9\u30c6\u30ed\u30a4\u30c9\u904e\u654f\u75c7\u3068\u30b9\u30c6\u30ed\u30a4\u30c9\u4f9d\u5b58\u75c7<\/strong><br>\u3057\u304b\u3057\u3001\u591a\u304f\u306e\u60a3\u8005\u306f\u526f\u814e\u76ae\u8cea\u30b9\u30c6\u30ed\u30a4\u30c9\u306b\u975e\u5e38\u306b\u3088\u304f\u53cd\u5fdc\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u5c0f\u5150\u7279\u96c6<\/strong><br>ADEM\u306f\u5c0f\u5150\uff0810\u6b73\u672a\u6e80\uff09\u306e\u521d\u767a\u75c7\u72b6\u3068\u3057\u3066\u6700\u3082\u591a\u3044\uff1b\u4e88\u5f8c\u306f\u826f\u597d\u306a\u3053\u3068\u304c\u591a\u3044\u304c\u3001\u518d\u767a\u306e\u30ea\u30b9\u30af\u304c\u3042\u308b\u3002<\/li>\n\n\n\n<li><strong>\u598a\u5a20\uff1a\u8584\u3044\u30c7\u30fc\u30bf<\/strong><br>\u598a\u5a20\u4e2d\u306e\u518d\u767a\u30ea\u30b9\u30af\u306f\u4e00\u822c\u306b\u5897\u52a0\u3057\u306a\u3044\u304c\u3001\u7523\u5f8c\u306f\u30ea\u30b9\u30af\u56e0\u5b50\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\uff08MS\u3068\u985e\u4f3c\uff09\u3002<\/li>\n<\/ul>\n\n\n\n<h1 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Zusammenfassung_und_Ausblick\"><\/span>\u7dcf\u62ec\u3068\u5c55\u671b<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">MOGAD\u306f\u72ec\u7acb\u3057\u305f\u3001\u6297\u4f53\u3092\u4ecb\u3059\u308bCNS\u306e\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3067\u3042\u308a\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u4e3b\u306a\u7279\u5fb4\u304c\u3042\u308b\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u3068\u30df\u30a8\u30ea\u30f3\u9798\u306e\u5916\u5074\u306b\u3042\u308bMOG\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u6a19\u7684\u6297\u539f\u3067\u3042\u308b<\/li>\n\n\n\n<li>\u75c5\u539f\u6027MOG-IgG1\u81ea\u5df1\u6297\u4f53\u306f\u3001\u88dc\u4f53\u6d3b\u6027\u5316\uff08CDC\u3001\u7d0450%\uff09\u3068Fc\u03b3R\u7d50\u5408\uff08ADCC\/ADCP\u3001\u7d0450%\uff09\u3068\u3044\u30462\u3064\u306e\u4e26\u884c\u3057\u305f\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u7d4c\u8def\u3092\u4ecb\u3057\u3066\u30df\u30a8\u30ea\u30f3\u3092\u50b7\u5bb3\u3059\u308b\u3002<\/li>\n\n\n\n<li>\u3055\u3089\u306b\u3001\u6297\u4f53\u306fFc\u03b3R\u6a5f\u69cb\u3092\u4ecb\u3057\u3066T\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3092\u5f37\u5316\u3059\u308b\u3002<\/li>\n\n\n\n<li>IL-6\/JAK\/STAT3\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306fTh17\u306e\u5206\u5316\u3068\u5f62\u8cea\u7d30\u80de\u306e\u6210\u719f\u3092\u4fc3\u9032\u3057\u3001\u91cd\u8981\u306a\u6cbb\u7642\u6a19\u7684\u3067\u3042\u308b<\/li>\n\n\n\n<li>\u73fe\u5728\u3001\u627f\u8a8d\u3055\u308c\u305f\u6cbb\u7642\u6cd5\u306f\u306a\u3044\uff082026\u5e742\u6708\u73fe\u5728\uff09\u3002\u6700\u521d\u306e\u7b2c3\u76f8RCT\u304c\u9032\u884c\u4e2d\uff08cosMOG\u3068\u30ed\u30b6\u30ce\u30ea\u30ad\u30b7\u30ba\u30de\u30d6\u3001METEOROID\u3068\u30b5\u30c8\u30e9\u30ea\u30ba\u30de\u30d6\uff09\u3002<\/li>\n\n\n\n<li>\u6cbb\u7642\u6cd5\u306f\u30ea\u30b9\u30af\u306b\u9069\u5fdc\u3057\u305f\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306b\u57fa\u3065\u304f\u6226\u7565\u306e\u65b9\u5411\u306b\u5411\u304b\u3063\u3066\u3044\u308b<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd1\u5e74\u306e\u6700\u3082\u91cd\u8981\u306a\u7814\u7a76\u9032\u5c55\u306f\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306b\u3088\u308b\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u6a5f\u69cb\uff08\u88dc\u4f53\u5bfeFcR\u7d4c\u8def\uff09\u306e\u6b63\u78ba\u306a\u89e3\u8aad\u3067\u3042\u308b\u3002 <strong>\u30de\u30a4\u30f3\u30eb\u3001\u30de\u30c0\u30fc\u3001\u5ddd\u4e0a\uff08LMU\u30df\u30e5\u30f3\u30d8\u30f3\uff09<\/strong>, \u3053\u308c\u306f\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u76f4\u63a5\u7684\u306a\u610f\u5473\u3092\u6301\u3064\uff1a\u6700\u9069\u306a\u6cbb\u7642\u6cd5\u306f\u3001IgG\u7523\u751f\uff08\u6297CD20\u3001FcRn\u963b\u5bb3\u5264\uff09\u3060\u3051\u3067\u306a\u304f\u3001\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u6a5f\u69cb\uff08\u88dc\u4f53\u3001Fc\u03b3R\uff09\u3084Th17\/IL-6\u8ef8\u306b\u3082\u5bfe\u51e6\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5bdb\u5bb9\u5c0e\u5165\u6226\u7565\u3068BTK\u963b\u5bb3\u5264\u306f\u3001\u4eca\u5f8c\u6570\u5e74\u306e\u3046\u3061\u306b\u81e8\u5e8a\u8a66\u9a13\u304c\u884c\u308f\u308c\u308b\u3067\u3042\u308d\u3046\u3001\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u57fa\u3065\u3044\u305f\u5c06\u6765\u306e\u6cbb\u7642\u539f\u5247\u3067\u3042\u308b\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Atherischer_Ole_%E2%80%93_Wirkstoffe_nach_Signalwegen_geordnet\"><\/span>\u30a8\u30c3\u30bb\u30f3\u30b7\u30e3\u30eb\u30aa\u30a4\u30eb - \u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u5225\u306b\u5206\u985e\u3055\u308c\u305f\u6709\u52b9\u6210\u5206<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u6d3b\u6027\u7269\u8cea\u306f\u3001MOGAD\u75c5\u614b\u751f\u7406\u306b\u304a\u3051\u308b\u653b\u6483\u30dd\u30a4\u30f3\u30c8\u306b\u5f93\u3063\u3066\u5206\u985e\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002MOGAD\u306b\u306f3\u3064\u306e\u4e3b\u8ef8\u304c\u3042\u308b\u305f\u3081\u3001\u3053\u308c\u306f\u6975\u3081\u3066\u91cd\u8981\u3067\u3042\u308b\uff1a <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Th17\/IL-6<\/strong><\/li>\n\n\n\n<li><strong>\u88dc\u4f53\u7cfb\uff0f\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u306e\u4fdd\u8b77<\/strong><\/li>\n\n\n\n<li><strong>\u30ec\u30df\u30a8\u30ea\u30f3\u5316\uff0fOPC\u5206\u5316<\/strong>.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Weihrauch_Boswellia_serrata_%E2%80%93_AKBA_und_Incensolacetat\"><\/span>\u30d5\u30e9\u30f3\u30ad\u30f3\u30bb\u30f3\u30b9\uff08Boswellia serrata\uff09 - AKBA\u304a\u3088\u3073\u9162\u9178\u30a4\u30f3\u30bb\u30f3\u30bd\u30fc\u30eb<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">BCP\u306b\u3088\u308c\u3070\u3001\u3053\u308c\u306fMOGAD\u306e\u5019\u88dc\u3068\u3057\u3066\u6700\u3082\u79d1\u5b66\u7684\u306b\u7acb\u8a3c\u3055\u308c\u305f\u3082\u306e\u3067\u3042\u308a\u3001\u305d\u306e\u52b9\u679c\u306e\u5e45\u306f\u7fa4\u3092\u629c\u3044\u3066\u3044\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>AKBA\uff083-O-\u30a2\u30bb\u30c1\u30eb-11-\u30b1\u30c8-\u03b2-\u30dc\u30b9\u30a6\u30a7\u30ea\u30f3\u9178\uff09<\/strong> \u304c\u4e3b\u306a\u6d3b\u6027\u539f\u7406\u3067\u3042\u308b\u3002AKBA\u306b\u306f\u3001\u6297\u611f\u67d3\u4f5c\u7528\u3001\u6297\u816b\u760d\u4f5c\u7528\u3001\u6297\u9178\u5316\u4f5c\u7528\u3001\u795e\u7d4c\u4fdd\u8b77\u4f5c\u7528\u306a\u3069\u3001\u8907\u6570\u306e\u751f\u7406\u4f5c\u7528\u304c\u3042\u308b\u3053\u3068\u304c\u8a3c\u660e\u3055\u308c\u3066\u3044\u308b\u3002\u795e\u7d4c\u306e\u4fee\u5fa9\u3068\u518d\u751f\u3092\u4fc3\u9032\u3057\u3001\u865a\u8840\u6027\u8133\u640d\u50b7\u304b\u3089\u4fdd\u8b77\u3057\u3001\u795e\u7d4c\u708e\u75c7\u3092\u6291\u5236\u3057\u3001\u8a18\u61b6\u969c\u5bb3\u3092\u6539\u5584\u3059\u308b\u3002. <a href=\"https:\/\/www.ean.org\/research\/resources\/neurology-updates\/detail\/complement-dependent-and-independent-pathomechanisms-of-myelin-oligodendrocyte-glycoprotein-mog-abs-implications-for-therapeutic-strategies-in-mog-antibody-associated-disease-mogad\" target=\"_blank\" rel=\"noreferrer noopener\">\u6b27\u5dde\u795e\u7d4c\u5b66\u4f1a<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>AKBA\u306fSTAT3\u3092\u963b\u5bb3\u3059\u308b<\/strong> STAT3\u306fIL-6\/JAK\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u4e3b\u8981\u306a\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u8ee2\u5199\u56e0\u5b50\u3067\u3042\u308a\u3001MOGAD\u306b\u304a\u3051\u308bTh17\u306e\u5206\u5316\u3068\u5f62\u8cea\u7d30\u80de\u306e\u6210\u719f\u3092\u4fc3\u9032\u3059\u308b\u3002\u52a0\u3048\u3066\u3001AKBA\u306b\u3088\u308bNrf2\/HO-1\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u306f\u3001\u9178\u5316\u30c0\u30e1\u30fc\u30b8\u3092\u8efd\u6e1b\u3057\u3001\u8131\u9ac4\u3092\u9632\u304e\u3001\u518d\u9ac4\u5316\u3092\u4fc3\u9032\u3059\u308b\u65b9\u5411\u6027\u3092\u63d0\u4f9b\u3059\u308b\u3002. <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.nanolett.9b02220\" target=\"_blank\" rel=\"noreferrer noopener\">ACS\u51fa\u7248\u7269<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">AKBA\u306f\u30015-LOX\u306815-LOX\u306e\u30a2\u30ed\u30b9\u30c6\u30ea\u30c3\u30af\u8abf\u7bc0\u3092\u901a\u3058\u3066\u30ed\u30a4\u30b3\u30c8\u30ea\u30a8\u30f3\u306e\u5f62\u6210\u3092\u963b\u5bb3\u3059\u308b\u3068\u540c\u6642\u306b\u3001SPM\uff08Specialised Pro-Resolving Mediators\uff09\u306e\u7523\u751f\u3092\u523a\u6fc0\u3059\u308b\u5206\u5b50\u30b9\u30a4\u30c3\u30c1\u3068\u3057\u3066\u50cd\u304f\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u514d\u75ab\u53cd\u5fdc\u3092\u7a4d\u6975\u7684\u306b\u6b21\u306e\u65b9\u5411\u306b\u30b7\u30d5\u30c8\u3055\u305b\u308b\u3002 <strong>\u708e\u75c7\u306e\u89e3\u6d88<\/strong>, \u6e1b\u8870\u3060\u3051\u3067\u306a\u304f\u3002. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39133885\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u30d1\u30d6\u30b3\u30e1<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u9162\u9178\u30a4\u30f3\u30bb\u30f3\u30bd\u30fc\u30eb<\/strong> (\u4e73\u9999\u7cbe\u6cb9\u306e\u63ee\u767a\u6027\u6210\u5206\u3067\u3042\u308bBHS\u306f\u3001PPAR-\u03b3\u3068\u540c\u69d8\u306b\u30cb\u30e5\u30fc\u30ed\u30f3\u306eTRPV3\u30c1\u30e3\u30f3\u30cd\u30eb\u3092\u6d3b\u6027\u5316\u3059\u308b - \u4e73\u9999\u6210\u5206\u306f\u3001\u708e\u75c7\u8a98\u767a\u5f8c\u306e\u8133\u306eIL-6\u3001TNF-\u03b1\u304a\u3088\u3073GFAP\uff08\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u6d3b\u6027\u5316\u306e\u30de\u30fc\u30ab\u30fc\uff09\u3092\u6709\u610f\u306b\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002. <a href=\"https:\/\/www.neurology.org\/doi\/10.1212\/NXI.0000000000200293\" target=\"_blank\" rel=\"noreferrer noopener\">\u795e\u7d4c\u5b66<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u54c1\u8cea\u306b\u95a2\u3059\u308b\u91cd\u8981\u306a\u6ce8\u610f\u4e8b\u9805\uff1a<\/strong> \u30dc\u30b9\u30a6\u30a7\u30ea\u30a2\u88fd\u54c1\u306e\u54c1\u8cea\u306b\u306f\u304b\u306a\u308a\u306e\u5dee\u304c\u3042\u308a\u3001\u4e00\u90e8\u306e\u88fd\u54c1\uff08H15 Ayurmedica\u00ae\u306a\u3069\uff09\u306e\u5206\u6790\u3067\u306f\u3001\u7279\u5fb4\u7684\u306a\u30dc\u30b9\u30a6\u30a7\u30ea\u30c3\u30af\u9178\u306f\u5fae\u91cf\uff080.31 mg AKBA\uff09\u3057\u304b\u542b\u307e\u308c\u3066\u3044\u306a\u304b\u3063\u305f\u3002\u5bfe\u7167\u7684\u306b\u3001\u30dc\u30b9\u30a6\u30a7\u30ea\u30a2\u30b5\u30f3\u00ae\uff087.51mg\uff09\u3084\u30b5\u30e9\u30ad\u00ae\u9320\uff087.88mg\uff09\u306e\u3088\u3046\u306a\u88fd\u54c1\u306f\u3001\u304b\u306a\u308a\u306e\u91cf\u306eAKBA\u3068\u305d\u308c\u306b\u5bfe\u5fdc\u3059\u308b\u5f37\u529b\u306a\u85ac\u7406\u52b9\u679c\u3092\u793a\u3057\u305f\u3002. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34358086\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u708e\u75c7\u3092\u8abf\u7bc0\u3059\u308b\u30d5\u30e9\u30f3\u30ad\u30f3\u30bb\u30f3\u30b9\u7cfb\u30ec\u30e1\u30c7\u30a3\u30fc\u306e\u30dc\u30b9\u30a6\u30a7\u30ea\u30f3\u9178\u542b\u91cf\u3068\u95a2\u9023\u85ac\u7406\u6d3b\u6027\u306e\u89e3\u6790<\/a> \u305d\u3057\u3066 <a href=\"https:\/\/www.frontiersin.org\/journals\/immunology\/articles\/10.3389\/fimmu.2025.1530977\/full\" target=\"_blank\" rel=\"noreferrer noopener\">\u30d5\u30ed\u30f3\u30c6\u30a3\u30a2<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30c9\u30c6\u30e9\u306e\u88fd\u54c1 <strong><a href=\"https:\/\/media.doterra.com\/us\/en\/pips\/frankincense-boswellic-acid-complex.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">\u30d5\u30e9\u30f3\u30ad\u30f3\u30bb\u30f3\u30b9\u30fb\u30dc\u30b9\u30a6\u30a7\u30eb\u9178\u30b3\u30f3\u30d7\u30ec\u30c3\u30af\u30b9<\/a><\/strong> AKBA*37.5mg\u542b\u6709<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Therapeutisch_relevante_AKBA-Zieldosen\"><\/span>AKBA\u306e\u6cbb\u7642\u76ee\u7684\u7528\u91cf<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u81e8\u5e8a\u304a\u3088\u3073\u524d\u81e8\u5e8a\u7814\u7a76\u304b\u3089\u3001\u6b21\u306e\u3088\u3046\u306a\u56f3\u5f0f\u304c\u6d6e\u304b\u3073\u4e0a\u304c\u3063\u3066\u304d\u305f\uff1a<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u30a2\u30d7\u30ea\u30b1\u30fc\u30b7\u30e7\u30f3\u306e\u76ee\u7684<\/th><th>AKBA\u306e1\u65e5\u6295\u4e0e\u91cf<\/th><th>\u30bd\u30fc\u30b9<\/th><\/tr><\/thead><tbody><tr><td>\u6297\u708e\u75c7\uff08\u5168\u822c\uff09<\/td><td>100-200mg<\/td><td>\u30d2\u30c8\u8a66\u9a13 \u95a2\u7bc0\/\u8178<\/td><\/tr><tr><td>NF-\u03baB \/ STAT3 \u963b\u5bb3\uff08\u795e\u7d4c\u708e\u75c7\uff09<\/td><td>200-400 mg<\/td><td>\u52d5\u7269\u30e2\u30c7\u30eb\u3001\u7d30\u80de\u57f9\u990a<\/td><\/tr><tr><td>\u6700\u9069\u306aCNS\u52b9\u679c\uff08\u30d0\u30ea\u30a2\u901a\u904e\u6027\uff09<\/td><td>200-300 mg<\/td><td>\u5b9f\u9a13\u30c7\u30fc\u30bf<\/td><\/tr><tr><td>\u5fcd\u5bb9\u6027\u306e\u9ad8\u30441\u65e5\u6700\u9ad8\u7528\u91cf<\/td><td>400-600 mg<\/td><td>\u8010\u6027\u7814\u7a76<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Umrechnung_auf_375_mg_AKBA_jeKapsel\"><\/span>1\u30ab\u30d7\u30bb\u30eb\u3042\u305f\u308aAKBA 37.5mg\u3078\u306e\u63db\u7b97<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>AKBA\u306e1\u65e5\u76ee\u6a19\u6295\u4e0e\u91cf<\/th><th>\u5358\u4f4d\/\u65e5<\/th><th>\u5b9f\u7528\u7684\u306a\u30b9\u30ad\u30fc\u30e0<\/th><\/tr><\/thead><tbody><tr><td>150 mg<\/td><td>4\u30e6\u30cb\u30c3\u30c8<\/td><td>\u671d2\u56de\uff0b\u5915\u65b92\u56de<\/td><\/tr><tr><td>200 mg<\/td><td><strong>5-6\u30e6\u30cb\u30c3\u30c8<\/strong><\/td><td>\u671d3\u56de\uff0b\u5915\u65b92\uff5e3\u56de<\/td><\/tr><tr><td>300 mg<\/td><td>8\u30e6\u30cb\u30c3\u30c8<\/td><td>\u671d4\u56de\uff0b\u5915\u65b94\u56de<\/td><\/tr><tr><td>400 mg<\/td><td>10\uff5e11\u53f0<\/td><td>1\u65e53\uff5e4\u30e6\u30cb\u30c3\u30c8<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30a8\u30f3\u30c8\u30ea\u30fc\u63a8\u5968\uff1a<\/strong> <strong>1\u65e54\u30e6\u30cb\u30c3\u30c8\uff08\uff1d150mg\u306eAKBA\uff09<\/strong>, \u30922\u3064\u306e\u30ae\u30d5\u30c8\u306b\u5206\u3051\u305f\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2\u9031\u9593\u5f8c\uff08\u5fcd\u5bb9\u6027\u304c\u826f\u597d\u306a\u5834\u5408\uff09\u30016\u5358\u4f4d\uff08\uff1d225mg\uff09\u306b\u5897\u91cf\u3059\u308b\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wichtige_Einnahmehinweise\"><\/span>\u6442\u53d6\u306b\u95a2\u3059\u308b\u91cd\u8981\u306a\u6307\u793a<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u8102\u80aa\u306f\u91cd\u8981\u3060\uff1a<\/strong> AKBA\u306f\u89aa\u6cb9\u6027\u304c\u9ad8\u3044\u3002 <strong>\u30d0\u30a4\u30aa\u30a2\u30d9\u30a4\u30e9\u30d3\u30ea\u30c6\u30a3\u304c2\uff5e3\u500d\u5411\u4e0a<\/strong>, \u8102\u80aa\u5206\u306e\u591a\u3044\u98df\u4e8b\u3068\u4e00\u7dd2\u306b\u6442\u308b\u3068\u3088\u3044\u3002\u30aa\u30ea\u30fc\u30d6\u30aa\u30a4\u30eb\u3001\u30a2\u30dc\u30ab\u30c9\u3001\u307e\u305f\u306f\u4e3b\u98df\u304c\u7406\u60f3\u7684\u3067\u3059\u3002\u7a7a\u8179\u6642\u306b\u6442\u53d6\u3059\u308b\u3068\u5438\u53ce\u7387\u304c\u6975\u7aef\u306b\u4f4e\u4e0b\u3059\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30bf\u30a4\u30df\u30f3\u30b0\u3060\uff1a<\/strong> AKBA\u306e\u534a\u6e1b\u671f\u306f\u7d046\u6642\u9593\u3067\u3042\u308b\u3002 <strong>1\u65e52\uff5e3\u56de<\/strong> \u3053\u308c\u306f\u3001\u5747\u4e00\u306a\u52b9\u679c\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306b\u30011\u56de\u306e\u6295\u4e0e\u3088\u308a\u3082\u7406\u306b\u304b\u306a\u3063\u3066\u3044\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>BCP\u3068\u306e\u4f75\u7528\uff1a<\/strong> AKBA\uff08STAT3\/NF-\u03baB\u8ef8\uff09\u3068BCP\uff08CB2\/Th17\u8ef8\uff09\u306f\u3001MOGAD\u306e\u7570\u306a\u308b\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306b\u5bfe\u5fdc\u3057\u3001\u76f8\u4e57\u7684\u306b\u4f5c\u7528\u3059\u308b\u3002\u85ac\u7406\u5b66\u7684\u76f8\u4e92\u4f5c\u7528\u306f\u77e5\u3089\u308c\u3066\u3044\u306a\u3044\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u80c3\u306e\u8010\u6027\uff1a<\/strong> \u30dc\u30b9\u30a6\u30a7\u30ea\u30a2\u306f\u4e00\u822c\u7684\u306b\u975e\u5e38\u306b\u5fcd\u5bb9\u6027\u304c\u9ad8\u3044\u3002\u9ad8\u7528\u91cf\u3067\u308f\u305a\u304b\u306a\u80c3\u523a\u6fc0\u304c\u8d77\u3053\u308b\u3053\u3068\u306f\u7a00\u3067\u3042\u308b\u3002\u305d\u306e\u305f\u3081\u3001\u5fc5\u305a\u98df\u4e8b\u3068\u4e00\u7dd2\u306b\u670d\u7528\u3059\u308b\u304b\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u4e00\u6642\u7684\u306b\u670d\u7528\u91cf\u3092\u6e1b\u3089\u3057\u3066\u304f\u3060\u3055\u3044\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Schwarzer_Pfeffer_oral\"><\/span>\u30d6\u30e9\u30c3\u30af\u30da\u30c3\u30d1\u30fc\uff08\u7d4c\u53e3\uff09<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u9ed2\u80e1\u6912\u6cb9\u306e\u4e3b\u306a\u6709\u52b9\u6210\u5206\u03b2-\u30ab\u30ea\u30aa\u30d5\u30a3\u30ec\u30f3\uff08BCP\uff09(<em>\u9ed2\u80e1\u6912<\/em>)\u306f\u3001\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3IL-6\u3001TNF-\u03b1\u3001IL-17\u3001IFN-\u03b3\u3001Th17\u306e\u8ee2\u5199\u56e0\u5b50(ROR-\u03b3t)\u3068Th1\u306e\u8ee2\u5199\u56e0\u5b50(T-bet)\u3092\u6e1b\u5c11\u3055\u305b\u3001\u6297\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3TGF-\u03b21\u3001IL-10\u3001IL-4\u3001Th2\u306e\u8ee2\u5199\u56e0\u5b50(GATA3)\u3068Treg\u306e\u8ee2\u5199\u56e0\u5b50(Foxp3)\u3092\u6709\u610f\u306b\u5897\u52a0\u3055\u305b\u308b\u3002\u3053\u308c\u3089\u306e\u52b9\u679c\u306f\u3001CB2\u53d7\u5bb9\u4f53\u306e\u6d3b\u6027\u5316\u3068\u53b3\u5bc6\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CB2\u53d7\u5bb9\u4f53\u3068\u518d\u9ac4\u9798\u5316\u306f\u3001\u30e1\u30ab\u30cb\u30ba\u30e0\u7684\u306b\u76f4\u63a5\u7684\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3002CB2\u30a2\u30b4\u30cb\u30ba\u30e0\u306fOPC\u306e\u6210\u719f\u3092\u4fc3\u9032\u3057\u3001\u6b21\u4e16\u4ee3CB2\u30a2\u30b4\u30cb\u30b9\u30c8\uff08Yhhu4952\uff09\u306f\u8133\u6881\u306e\u30df\u30a8\u30ea\u30f3\u5869\u57fa\u6027\u30bf\u30f3\u30d1\u30af\u8cea\uff08MBP\uff09\u306e\u767a\u73fe\u3068\u6210\u719f\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u306e\u5272\u5408\u3092\u6709\u610f\u306b\u5897\u52a0\u3055\u305b\u305f\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30d6\u30e9\u30c3\u30af\u30da\u30c3\u30d1\u30fc\u306e\u7528\u6cd5\u30fb\u7528\u91cf\uff1a20 ...200mg\/\u65e5-20tr.\/\u65e5\u306b\u76f8\u5f53\u3059\u308b\u306e\u3067\u30018\u6642\u9593\u3054\u3068\u306b7trp.\u3092\uff08\u3088\u308a\u9ad8\u3044\u8840\u6f3f\u4e2d\u6fc3\u5ea6\u306e\u305f\u3081\u306b\u306f6\u6642\u9593\u3054\u3068\u306b5trp.\u3092\uff09\u30ad\u30e3\u30ea\u30a2\u30aa\u30a4\u30eb\u306b\u6eb6\u304b\u3057\u3066\u30ab\u30d7\u30bb\u30eb\u306b\u5165\u308c\u3066\u670d\u7528\u3059\u308b\u306e\u304c\u3088\u3044\u3002\u9ad8\u8102\u80aa\u306e\u98f2\u98df\u7269\u3068\u4e00\u7dd2\u306b\u6442\u53d6\u3059\u308b\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Schwarzer_Pfeffer_Inhalation\"><\/span>\u30d6\u30e9\u30c3\u30af\u30da\u30c3\u30d1\u30fc\uff08\u5438\u5165\uff09<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u7528\u6cd5\u30fb\u7528\u91cf: \u65e5\u4e2d\u30014\u6642\u9593\u3054\u3068\u306b3\u6ef4\uff08\u534a\u6e1b\u671f\u306f2-4\u6642\u9593\uff09\u309220\u5206\u9593\u3001\u52a0\u71b1\u3055\u308c\u305f\u30c7\u30a3\u30d5\u30e5\u30fc\u30b6\u30fc\u306e\u30ea\u30ad\u30d1\u30c3\u30c9\u306b\u5438\u5165\u3057\u3001\u6df1\u547c\u5438\u306e\u305f\u3073\u306b\u7d045-8\u79d2\u9593\u606f\u3092\u6b62\u3081\u307e\u3059\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u9ed2\u80e1\u6912\u306b\u306f\u8208\u596e\u4f5c\u7528\u304c\u3042\u308a\u3001\u7761\u7720\u3092\u59a8\u3052\u308b\u3053\u3068\u304c\u3042\u308b\u3002\u3053\u306e\u5834\u5408\u3001\u591c\u9593\u306e\u6563\u5e03\u306f\u907f\u3051\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u547c\u5438\u5668\u304c\u523a\u6fc0\u3055\u308c\u305f\u308a\uff08\u4e7e\u71e5\uff09\u3001\u982d\u75db\u304c\u751f\u3058\u305f\u308a\u3057\u305f\u5834\u5408\uff1a\u7528\u91cf\u3092\u6e1b\u3089\u3059\u304b\u3001\u9593\u9694\u3092\u3042\u3051\u308b\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Copaiba-Ol_oral_%E2%80%93_NUR_doTERRA\"><\/span>\u30b3\u30d1\u30a4\u30d0\u30aa\u30a4\u30eb\uff08\u7d4c\u53e3\uff09-\u30c9\u30c6\u30e9\u793e\u306e\u307f<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">52.6 % BCP - 1\u6ef4\u3042\u305f\u308a14.7mg\u306eBCP\u306b\u76f8\u5f53 - BCP\u306f\u89aa\u6cb9\u6027\u3067\u3042\u308b\u305f\u3081\u3001\u5fc5\u305a\u9ad8\u8102\u80aa\u306e\u98f2\u98df\u7269\u3068\u4e00\u7dd2\u306b\u670d\u7528\u3059\u308b\u3053\u3068\uff01<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u81e8\u5e8a\u5b89\u5168\u6027\u8a66\u9a13\u306b\u3088\u308c\u3070\u3001\u4f53\u91cd\u306b\u57fa\u3065\u304f\u63a8\u5968\u7528\u91cf\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3042\u308b\uff1a<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"MOGAD-spezifische_Dosierungstabelle_doTERRA_Copaiba_525_BCP\"><\/span>MOGAD\u5c02\u7528\u670d\u7528\u8868\uff08doTERRA \u30b3\u30d1\u30a4\u30d052.5 % BCP\uff09<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u4f53\u91cd<\/th><th><strong>\u81ea\u7136\u4fdd\u8b77<\/strong> (0.4mg\/kg\uff09<\/th><th><strong>\u30a2\u30af\u30c6\u30a3\u30d6\u30fb\u30b9\u30e9\u30b9\u30c8<\/strong> (mg\/kg\uff09<\/th><th><strong>\u96c6\u4e2d\u6cbb\u7642<\/strong> (mg\/kg\uff09<\/th><\/tr><\/thead><tbody><tr><td><strong>50\u30ad\u30ed<\/strong><\/td><td>20 mg = <strong>1-2\u6ef4<\/strong><\/td><td>50 mg = <strong>3-4\u6ef4<\/strong><\/td><td>75mg\uff1d\uff1d\u3002 <strong>5\u6ef4<\/strong><\/td><\/tr><tr><td><strong>60\u30ad\u30ed<\/strong><\/td><td>24mg\uff1d\uff1d\u3002 <strong>2\u6ef4<\/strong><\/td><td>60mg\uff1d\uff1d\u3002 <strong>4\u6ef4<\/strong><\/td><td>90 mg = <strong>6\u6ef4<\/strong><\/td><\/tr><tr><td><strong>70\u30ad\u30ed<\/strong><\/td><td>28 mg = <strong>2\u6ef4<\/strong><\/td><td>70 mg = <strong>5\u6ef4<\/strong><\/td><td>105 mg = <strong>7\u6ef4<\/strong><\/td><\/tr><tr><td><strong>80\u30ad\u30ed<\/strong><\/td><td>32\u30df\u30ea\u30b0\u30e9\u30e0 <strong>2\u6ef4<\/strong><\/td><td>80 mg = <strong>5-6\u6ef4<\/strong><\/td><td>120mg\uff1d\uff1d\u3002 <strong>8\u6ef4<\/strong><\/td><\/tr><tr><td><strong>90\u30ad\u30ed<\/strong><\/td><td>36\u30df\u30ea\u30b0\u30e9\u30e0 <strong>2-3\u6ef4<\/strong><\/td><td>90 mg = <strong>6\u6ef4<\/strong><\/td><td>135\u30df\u30ea\u30b0\u30e9\u30e0 <strong>9\u6ef4<\/strong><\/td><\/tr><tr><td><strong>100\u30ad\u30ed<\/strong><\/td><td>40mg\uff1d\uff1d\u3002 <strong>3\u6ef4<\/strong><\/td><td>100 mg = <strong>7\u6ef4<\/strong><\/td><td>150 mg = <strong>10\u6ef4<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"MOGAD-Phasen-adaptierte_Dosierung\"><\/span>MOGAD\u76f8\u9806\u6295\u4e0e<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Phase_1_Akuter_Schub_erste_2%E2%80%934_Wochen\"><\/span><strong>\u7b2c1\u6bb5\u968e\uff1a\u6025\u6027\u5897\u60aa\u671f\uff08\u6700\u521d\u306e2\uff5e4\u9031\u9593\uff09<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30bf\u30fc\u30b2\u30c3\u30c8<\/strong> \u7a4d\u6975\u7684\u306aTh17\u6291\u5236\u3001IL-6\u306e\u6e1b\u5c11<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6295\u4e0e\u91cf\uff1a<\/strong> 1.0\uff5e1.5mg\/kg\/\u65e5<\/li>\n\n\n\n<li><strong>\u5272\u308a\u5f53\u3066\uff1a<\/strong> 1\u65e53\u56de\uff08CB2\u53d7\u5bb9\u4f53\u306e\u6301\u7d9a\u7684\u6d3b\u6027\u5316\u306b\u6700\u9069\uff09<\/li>\n\n\n\n<li><strong>\u4f8b 70\u30ad\u30ed\uff1a<\/strong> 1\u65e55\uff5e7\u6ef4\u30012+2+3\u6ef4\u306e\u5272\u5408\u3067\u6ef4\u4e0b\u3059\u308b<\/li>\n\n\n\n<li><strong>\u30b3\u30f3\u30d3\u30cd\u30fc\u30b7\u30e7\u30f3\uff1a<\/strong> AKBA\uff08STAT3\u963b\u5bb3\u306e\u305f\u3081200\uff5e300mg\/\u65e5\uff09\uff0b\u9ad8\u7528\u91cf\u30b3\u30eb\u30c1\u30be\u30f3\uff08\u6a19\u6e96\uff09\u3092\u4f75\u7528<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Phase_2_Schubremission_Erhaltung_langfristig\"><\/span><strong>\u30d5\u30a7\u30fc\u30ba2\uff1a\u518d\u767a\u5bdb\u89e3\uff0f\u7dad\u6301\uff08\u9577\u671f\uff09<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30bf\u30fc\u30b2\u30c3\u30c8<\/strong> \u518d\u767a\u9632\u6b62\u3001\u6297\u708e\u75c7\u4f5c\u7528\u306e\u6301\u7d9a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6295\u4e0e\u91cf\uff1a<\/strong> 1\u65e50.4\uff5e0.7mg\/kg<\/li>\n\n\n\n<li><strong>\u5272\u308a\u5f53\u3066\uff1a<\/strong> 1\u65e52\u56de<\/li>\n\n\n\n<li><strong>\u4f8b 70\u30ad\u30ed\uff1a<\/strong> 1\u65e52\uff5e3\u6ef4\u30011+2\u307e\u305f\u306f2+2\u3068\u3057\u3066\u6ef4\u4e0b\u3059\u308b\u3002<\/li>\n\n\n\n<li><strong>\u30b3\u30f3\u30d3\u30cd\u30fc\u30b7\u30e7\u30f3\uff1a<\/strong> AKBA\u3068\u4f75\u7528\uff08150mg\/\u65e5\uff09 \u30aa\u30d7\u30b7\u30e7\u30f3<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Phase_3_Monophasischer_Verlauf_Titer_fallend\"><\/span><strong>\u7b2c3\u6bb5\u968e\uff1a\u5358\u76f8\u30b3\u30fc\u30b9\uff08\u529b\u4fa1\u4f4e\u4e0b\uff09<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30bf\u30fc\u30b2\u30c3\u30c8<\/strong> \u795e\u7d4c\u4fdd\u8b77\u3001\u518d\u9ac4\u9798\u5316<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6295\u4e0e\u91cf\uff1a<\/strong> 1\u65e50.2\uff5e0.4mg\/kg<\/li>\n\n\n\n<li><strong>\u5272\u308a\u5f53\u3066\uff1a<\/strong> 1\u65e51\uff5e2\u56de<\/li>\n\n\n\n<li><strong>\u4f8b 70\u30ad\u30ed\uff1a<\/strong> 1\u65e51\uff5e2\u6ef4<\/li>\n\n\n\n<li><strong>\u30d0\u30e9\u30f3\u30b9\u8abf\u6574\u53ef\u80fd<\/strong> 6\uff5e12\u30f5\u6708\u9593\u306e\u5b89\u5b9a\u3057\u305f\u8840\u6e05\u53cd\u5fdc\u9670\u6027\u5f8c<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Quellen\"><\/span>\u60c5\u5831\u6e90<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6bd2\u6027\uff08700 mg\/kg NOAEL\uff09<\/strong><br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27358239\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/27358239\/<\/a><\/li>\n\n\n\n<li><strong>EAE\u30e2\u30c7\u30eb\uff08\u6709\u52b92.5\uff5e5 mg\/kg\uff09<\/strong><br><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10377147\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10377147\/<\/a><\/li>\n\n\n\n<li><strong>\u30d2\u30c8\u8a66\u9a13\uff08100mg\u306f\u5b89\u5168\uff09<\/strong><br><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9104399\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9104399\/<\/a><\/li>\n\n\n\n<li><strong>\u81e8\u5e8a\u8a66\u9a13\uff08\u6709\u52b9126mg\/\u65e5\uff09<\/strong><br><a href=\"https:\/\/accurateclinic.com\/accurate-education-terpenes-caryophyllene\/\" target=\"_blank\" rel=\"noopener\">https:\/\/accurateclinic.com\/accurate-education-terpenes-caryophyllene\/<\/a><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Copaiba-Ol_Inhalation\"><\/span>\u30b3\u30d1\u30a4\u30d0\u30aa\u30a4\u30eb\uff08\u5438\u5165\uff09<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u6700\u592738% BCP\u306e\u30d6\u30e9\u30c3\u30af\u30da\u30c3\u30d1\u30fc\u306b\u52a0\u3048\u3001\u6700\u592787% BCP\u306e\u30b3\u30d1\u30a4\u30d0\u30aa\u30a4\u30eb\u306f\u306f\u308b\u304b\u306b\u5f37\u529b\u3067\u3042\u308b\u305f\u3081\u3001\u5438\u5165\u306b\u6700\u9069\u3067\u3042\u308b\u3002.<br>\u30c7\u30a3\u30d5\u30e5\u30fc\u30b6\u30fc\u306f\u901a\u5e38\u3001\u4f4e\u6e29\u8d85\u97f3\u6ce2\uff08US\uff09\u5674\u9727\u3067\u4f5c\u52d5\u3059\u308b\u3002\u3057\u304b\u3057\u3001BCP\u306f\u7d04130 \u00b0C\u304b\u3089\u3057\u304b\u6c17\u5316\u305b\u305a\u3001180 \u00b0C\u4ee5\u4e0a\u3067\u71c3\u713c\u3059\u308b\u3002\u305d\u306e\u305f\u3081\u3001\u52a0\u71b1\u53ef\u80fd\u3067\u6e29\u5ea6\u5236\u5fa1\u53ef\u80fd\u306a\u30c7\u30a3\u30d5\u30e5\u30fc\u30b6\u30fc\u3092\u4f7f\u7528\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\uff08\u4f8b\u3048\u3070\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u3082\u306e\uff09\u3002. <a href=\"https:\/\/storz-bickel.com\" target=\"_blank\" rel=\"noreferrer noopener\">\u30dc\u30eb\u30b1\u30fc\u30ce\u30fb\u30af\u30e9\u30b7\u30c3\u30af\u3001\u30dc\u30eb\u30b1\u30fc\u30ce\u30fb\u30cf\u30a4\u30d6\u30ea\u30c3\u30c9\u3001\u30de\u30a4\u30c6\u30a3+\u306e\u3044\u305a\u308c\u304b<\/a>)\u306e\u7d04270\uff5e415\u30e6\u30fc\u30ed\u306e\u4fa1\u683c\u5e2f\u3067\u3001\u6e29\u5ea6\u306f\u3067\u304d\u308b\u3060\u3051\u6b63\u78ba\u306b160\u2103\u306b\u8a2d\u5b9a\u3059\u308b\u3053\u3068\uff08\u8d64\u5916\u7dda\u6e29\u5ea6\u8a08\u3067\u78ba\u8a8d\uff09\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">BCP\u542b\u6709\u91cf69 %\u306e\u30b3\u30d1\u30a4\u30d0\u30aa\u30a4\u30eb\uff08\u30c9\u30c6\u30e9\u793e\uff09\u306e\u63a8\u5968\u6442\u53d6\u91cf - 1\u6ef4\u4e2d\u306b18.6mg\u306eBCP\u3092\u542b\u6709\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">BCP\u306e\u534a\u6e1b\u671f\u306f2\uff5e4\u6642\u9593\u3067\u3042\u308b\u3002\u6709\u52b9\u6210\u5206\u306e\u6fc3\u5ea6\u3092\u3067\u304d\u308b\u3060\u3051\u4e00\u5b9a\u306b\u3059\u308b\u305f\u3081\u3001\u4e0a\u8a18\u306e\u3088\u3046\u306b4\u6642\u9593\u3054\u3068\u306b4\u6ef4\uff08\u7d04200mg\u306eBCP\u306b\u76f8\u5f53\uff09\u3092\u5438\u5165\u3059\u308b\u3002\u591c\u9593\u306f\u30c7\u30a3\u30d5\u30e5\u30fc\u30b6\u30fc\u3092\u30d9\u30c3\u30c9\u306e\u8fd1\u304f\u3067\u4f5c\u52d5\u3055\u305b\u3066\u304a\u304f\u3053\u3068\u3082\u3067\u304d\u308b\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Zieldosen_und_benotigte_Tropfenzahl\"><\/span>\u76ee\u6a19\u6295\u4e0e\u91cf\u3068\u5fc5\u8981\u6ef4\u6570<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u76ee\u6a19BCP\u6295\u4e0e\u91cf<\/th><th>\u30b3\u30d1\u30a4\u30d0\u30aa\u30a4\u30eb<\/th><th>\u7dcf\u6cb9\u5206(mg)<\/th><\/tr><\/thead><tbody><tr><td>BCP20mg\uff08\u958b\u59cb\u7528\u91cf\uff09<\/td><td><strong>~1\u6ef4<\/strong><\/td><td>~29 mg<\/td><\/tr><tr><td>50mg\u306eBCP<\/td><td><strong>~3\u6ef4<\/strong><\/td><td>~72mg<\/td><\/tr><tr><td>BCP100mg\uff08\u6cbb\u7642\u7528\uff09<\/td><td><strong>~5\uff5e6\u6ef4<\/strong><\/td><td>~145\u30df\u30ea\u30b0\u30e9\u30e0<\/td><\/tr><tr><td>BCP120mg\uff081\u65e5\u306e\u4e0a\u9650\u91cf\uff09<\/td><td><strong>~6\uff5e7\u6ef4<\/strong><\/td><td>~174mg<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u6a19\u7684\u5438\u5165BCP<\/th><th>\u30ea\u30ad\u30c3\u30c9\u30d1\u30c3\u30c9\u4e0a\u306e\u30aa\u30a4\u30eb\u91cf<\/th><th>\u30c9\u30ed\u30c3\u30d7\u30b9<\/th><\/tr><\/thead><tbody><tr><td>~BCP20mg\u5438\u5165<\/td><td>~40mg\u306e\u30aa\u30a4\u30eb\uff08\uff5e78mg\/0.69\uff09<\/td><td><strong>2-3\u6ef4<\/strong><\/td><\/tr><tr><td>~BCP\u5438\u516550mg<\/td><td>~100mg\u306e\u30aa\u30a4\u30eb<\/td><td><strong>4\uff5e5\u6ef4<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Synergistische_MOGAD-Strategie_Multi-Target\"><\/span>\u76f8\u4e57\u7684MOGAD\u6226\u7565\uff08\u30de\u30eb\u30c1\u30bf\u30fc\u30b2\u30c3\u30c8\uff09<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">MOGAD\u306b\u306f3\u3064\u306e\u75c5\u614b\u6a5f\u5e8f\u304c\u3042\u308b\u305f\u3081\u3001\u3053\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u3044\u305f\u7d44\u307f\u5408\u308f\u305b\u306f\u3001\u7d50\u679c\u3068\u3057\u3066\u305d\u3046\u306a\u308b\uff1a<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u6709\u52b9\u6210\u5206<\/th><th>\u6295\u4e0e\u91cf<\/th><th>\u4fe1\u53f7\u7d4c\u8def<\/th><th>MOGAD\u306e\u95a2\u9023\u6027<\/th><\/tr><\/thead><tbody><tr><td><strong>BCP\uff08\u7d4c\u53e3\uff09<\/strong><\/td><td>0.4-1.5 mg\/kg<\/td><td>CB2\u2192Th17\u2193\u3001IL-6\u2193\u3001Nrf2\/HO-1\u2191\u3002<\/td><td>\u2605\u2605\u2605\u2605\u2605<\/td><\/tr><tr><td><strong>AKBA\uff08\u7d4c\u53e3\uff09<\/strong><\/td><td>200\uff5e400mg\/\u65e5<\/td><td>STAT3\u2193\u3001NF-\u03baB\u2193\u30015-LOX\u2193\u3002<\/td><td>\u2605\u2605\u2605\u2605\u2605<\/td><\/tr><tr><td><strong>BCP\uff08\u5438\u5165\u3001160 \u00b0C\uff09<\/strong><\/td><td>2-3\u6ef4\u30011\u65e52\u56de<\/td><td>\u30ea\u30f3\u30d3\u30c3\u30af\u6027\u3001\u6025\u901f\u306a\u4e2d\u67a2\u795e\u7d4c\u7cfb\u3078\u306e\u6d78\u900f<\/td><td>\u2605\u2605\u2605<\/td><\/tr><tr><td><strong>\u30d5\u30e9\u30f3\u30ad\u30f3\u30bb\u30f3\u30b9\u30aa\u30a4\u30eb\uff08\u5438\u5165\uff09<\/strong><\/td><td>3\uff5e4\u6ef4\u30011\u65e52\u56de<\/td><td>\u9162\u9178\u30a4\u30f3\u30bb\u30f3\u30bd\u30fc\u30eb \u2192 TRPV3, PPAR-\u03b3<\/td><td>\u2605\u2605\u2605<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e4\u672c\u67f1\u306e\u6226\u7565\u306f\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u3082\u306e\u3060\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Th17\/IL-6<\/strong> (BCP\u7d4c\u53e3\uff0bAKBA\uff09<\/li>\n\n\n\n<li><strong>\u30b9\u30bf\u30c3\u30c8\u30b9\u30ea\u30fc<\/strong> (AKBA)<\/li>\n\n\n\n<li><strong>\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u306e\u4fdd\u8b77<\/strong> \uff08BCP\u306eNrf2\u6d3b\u6027\u5316\uff09<\/li>\n\n\n\n<li><strong>\u8fba\u7e01\u5909\u8abf<\/strong> \u5438\u5165<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wichtige_MOGAD-spezifische_Hinweise\"><\/span>MOGAD\u56fa\u6709\u306e\u91cd\u8981\u60c5\u5831<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>\u5358\u5264\u7642\u6cd5\u306a\u3057<\/strong> - BCP\/AKBA\u306f <strong>\u5f93\u6765\u7642\u6cd5\u3078\u306e\u8ffd\u52a0\u7642\u6cd5<\/strong><br>(\u6025\u6027\u671f\u306b\u306f\u30b3\u30eb\u30c1\u30be\u30f3\u3001\u5fc5\u8981\u3067\u3042\u308c\u3070\u4e88\u9632\u7684\u306b\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\/MMF\/IVIG\u3092\u6295\u4e0e\uff09-\u6c7a\u3057\u3066\u4ee3\u66ff\u7642\u6cd5\u3067\u306f\u306a\u3044<\/li>\n\n\n\n<li><strong>\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\uff1a<\/strong>\n<ul class=\"wp-block-list\">\n<li>3\uff5e6\u30f5\u6708\u3054\u3068\u306eMOG-IgG\u6297\u4f53\u4fa1<\/li>\n\n\n\n<li>\u6d3b\u6027\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u306esNfL\uff08\u30cb\u30e5\u30fc\u30ed\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u30e9\u30a4\u30c8<\/li>\n\n\n\n<li>\u529b\u4fa1\u304c\u6052\u5e38\u7684\u306b\u4f4e\u4e0b\u3057\u305f\u5834\u5408\u306f\u3001\u6295\u4e0e\u91cf\u306e\u6e1b\u91cf\u3092\u691c\u8a0e\u3059\u308b\u3002<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u30b9\u30e9\u30b9\u30c8\u30c8\u30ea\u30ac\u30fc\u3092\u898b\u308b<\/strong> - \u611f\u67d3\u75c7\u304c\u4e3b\u306a\u5f15\u304d\u91d1<br>\u611f\u67d3\u75c7\u306e\u5834\u5408\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u6295\u4e0e\u3059\u308b <strong>\u4e00\u6642\u7684\u306b1.5mg\/kg\u306b\u5897\u91cf<\/strong> \u4e88\u9632<\/li>\n\n\n\n<li><strong>\u30b3\u30d1\u30a4\u30d0\u306e\u809d\u81d3\u5024<\/strong> - 1mg\/kg\u4ee5\u4e0a\u30923\u30f5\u6708\u4ee5\u4e0a\u6295\u4e0e\u3057\u305f\u5834\u5408<br>ALT\/AST\u30923\u30ab\u6708\u3054\u3068\u306b\u30c1\u30a7\u30c3\u30af\u3059\u308b<\/li>\n\n\n\n<li><strong>\u30d6\u30e9\u30c3\u30af\u30da\u30c3\u30d1\u30fc\u306e\u4ee3\u66ff\u54c1<\/strong> - \u30b3\u30d1\u30a4\u30d0\u304c\u6c17\u306b\u306a\u308b\u65b9\u3078\uff1a\u30d6\u30e9\u30c3\u30af\u30da\u30c3\u30d1\u30fc\u30aa\u30a4\u30eb\uff0825-38 % BCP\uff09<br>\u6b21\u306b\u3001\u6ef4\u4e0b\u6570\u00d72\u3092\u8a08\u7b97\u3059\u308b\u3002<\/li>\n<\/ol>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%CE%B1-Asaron_Kalmus-Ol_Acorus_calamus_%E2%80%93_direkt_oligodendrozytenprotektiv\"><\/span>\u03b1-\u30a2\u30b5\u30ed\u30f3\uff08\u30ab\u30e9\u30de\u30b9\u6cb9\u3001, <em>\u83d6\u84b2<\/em>) - \u76f4\u63a5\u7684\u306b\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u3092\u4fdd\u8b77\u3059\u308b\u3002<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u3092\u6301\u3064\u6570\u5c11\u306a\u3044\u6709\u52b9\u6210\u5206\u306e\u3072\u3068\u3064\u3067\u3042\u308b\u3002 <strong>\u76f4\u63a5\u30ec\u30df\u30a8\u30ea\u30f3\u5316\u52b9\u679c<\/strong> \u306f <em><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37146420\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u03b1-\u30a2\u30b5\u30ed\u30f3<\/a><\/strong><\/em>. .\u4f4e\u9178\u7d20\u865a\u8840\u5f8c\u306e\u6210\u719f\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u306e\u55aa\u5931\u306b\u3088\u308b\u9ac4\u9798\u5f62\u6210\u4e0d\u5168\u3092\u3001\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306b\u304a\u3051\u308bPPAR-\u03b3\u306e\u30a2\u30c3\u30d7\u30ec\u30ae\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3068\u6d3b\u6027\u5316\u306b\u3088\u3063\u3066\u6539\u5584\u3059\u308b\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fcGLT-1\u306e\u767a\u73fe\u304c\u5897\u52a0\u3057\u3001\u904e\u5270\u306a\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u304c\u7d30\u80de\u5916\u7a7a\u9593\u304b\u3089\u9664\u53bb\u3055\u308c\u308b\u3002\u3053\u306e\u3088\u3046\u306a\u904e\u5270\u306a\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u306f\u3001\u305d\u3046\u3067\u306a\u3051\u308c\u3070OPC\u306b\u304a\u3044\u3066\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u5a92\u4ecb\u6027\u306e\u8208\u596e\u6bd2\u6027\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u305d\u306e\u5206\u5316\u3092\u963b\u5bb3\u3057\u3001\u7d30\u80de\u6b7b\u3092\u8a98\u5c0e\u3059\u308b\u3067\u3042\u308d\u3046\u3002. <a href=\"https:\/\/www.klinikum.uni-heidelberg.de\/neurologische-klinik\/neurologie-und-poliklinik\/forschung\/neuroimmunology\/ag-molekulare-neuroimmunologie\/mog-enzephalomyelitis\" target=\"_blank\" rel=\"noreferrer noopener\">\u30cf\u30a4\u30c7\u30eb\u30d9\u30eb\u30af\u5927\u5b66\u75c5\u9662<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u795e\u7d4c\u5b66\u306b\u304a\u3051\u308bPPARy <a href=\"https:\/\/www.frontiersin.org\/journals\/neuroscience\/articles\/10.3389\/fnins.2022.1060515\/pdf\" target=\"_blank\" rel=\"noreferrer noopener\">\u30d5\u30ed\u30f3\u30c6\u30a3\u30a2\u7de8\u96c6\u90e8 2022<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6ce8\u76ee\u3057\u3066\u307b\u3057\u3044\uff1a<\/strong> \u7523\u5730\u306b\u3088\u3063\u3066\u3001\u30ab\u30e9\u30de\u30b9\u6cb9\u306b\u542b\u307e\u308c\u308b\u03b2-\u30a2\u30b5\u30ed\u30f3\u306e\u91cf\u306f\u7570\u306a\u308b\u304c\u3001\u3053\u308c\u306f\u5909\u7570\u539f\u6027\u306b\u5206\u985e\u3055\u308c\u308b\u3002\u552f\u4e00 <strong>\u03b2-\u30a2\u30b5\u30ed\u30f3\u3092\u542b\u307e\u306a\u3044\u54c1\u8cea<\/strong> (Acorus calamus var. americanus\uff09\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u73fe\u72b6\uff082026\u5e742\u6708\uff09\u3067\u306f\u3001\u5e02\u5834\u306b\u51fa\u56de\u308b\u3053\u3068\u306f\u306a\u3044\u3002.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Geraniumol_Pelargonium_graveolens_%E2%80%93_Neuroinflammation_und_NO\"><\/span>\u30bc\u30e9\u30cb\u30a6\u30e0\u30fb\u30aa\u30a4\u30eb<em>\u30da\u30e9\u30eb\u30b4\u30cb\u30a6\u30e0<\/em>\u795e\u7d4c\u708e\u75c7\u3068NO<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7922935\/\" rel=\"nofollow noopener\" target=\"_blank\">\u30bc\u30e9\u30cb\u30a6\u30e0\u6cb9<\/a> \u306f\u3001\u795e\u7d4c\u708e\u75c7\u304c\u75c5\u614b\u751f\u7406\u306e\u4e00\u90e8\u3067\u3042\u308b\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u304a\u3044\u3066\u6709\u7528\u3067\u3042\u308d\u3046\u3002.<br>\u4e3b\u306a\u6709\u52b9\u6210\u5206 <em>\u30b7\u30c8\u30ed\u30cd\u30ed\u30fc\u30eb<\/em> \u306f\u9ad8\u6fc3\u5ea6\u3067\u512a\u308c\u305fNO\u7523\u751f\u6291\u5236\u6d3b\u6027\u3092\u793a\u3057\u305f\u304c\u3001\u3053\u308c\u306f\u6210\u5206\u9593\u306e\u76f8\u4e57\u4f5c\u7528\u304c\u6c7a\u5b9a\u7684\u3067\u3042\u308b\u3002.<br>\u30b7\u30c8\u30ed\u30cd\u30ed\u30fc\u30eb\u306f\u307e\u305f\u3001MOGAD\u306b\u304a\u3051\u308b\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u6d3b\u6027\u5316\u306b\u76f4\u63a5\u95a2\u4fc2\u3059\u308bNF-\u03baB\u3092\u963b\u5bb3\u3059\u308b\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Teebaum-Ol_Melaleuca_alternifolia_%E2%80%93_Mikroglia-Modulation\"><\/span>\u30c6\u30a3\u30fc\u30c4\u30ea\u30fc\u30aa\u30a4\u30eb<em>\u30aa\u30eb\u30bf\u30cb\u30d5\u30a9\u30ea\u30a2<\/em>\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u8abf\u7bc0<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10350368\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u30c6\u30a3\u30fc\u30c4\u30ea\u30fc\u30aa\u30a4\u30eb<\/a> \u304a\u3088\u3073\u305d\u306e\u4e3b\u6210\u5206\u306f\u3001AChE\u304a\u3088\u3073BChE\u306a\u3089\u3073\u306bLOX\u3092\u963b\u5bb3\u3059\u308b\u3002\u6297\u9178\u5316\u4f5c\u7528\u3001\u795e\u7d4c\u708e\u75c7\u6291\u5236\u4f5c\u7528\u3001AChE\/BChE\u963b\u5bb3\u4f5c\u7528\u306b\u3088\u308b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u6700\u9069\u5316\u306f\u3001\u7dcf\u5408\u7684\u306a\u6226\u7565\u3068\u3057\u3066\u795e\u7d4c\u7d30\u80de\u6b7b\u306e\u4e88\u9632\u306b\u52b9\u679c\u7684\u306b\u5bc4\u4e0e\u3059\u308b\u3002.<br>\u30c6\u30eb\u30d4\u30cd\u30f3-4-\u30aa\u30fc\u30eb\uff08\u4e3b\u306a\u6709\u52b9\u6210\u5206\uff09\u306f\u3001\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306eM1\u5206\u6975\u5316\u3082\u7279\u7570\u7684\u306b\u963b\u5bb3\u3059\u308b\u3002.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wirkstoffubersicht_nach_MOGAD-Signalwegen\"><\/span>MOGAD\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306b\u3088\u308b\u6d3b\u6027\u7269\u8cea\u306e\u6982\u8981<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u6709\u52b9\u6210\u5206<\/th><th>\u30aa\u30a4\u30eb\u30bd\u30fc\u30b9<\/th><th>MOGAD\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def<\/th><th>\u8a3c\u62e0\u306e\u5f37\u3055<\/th><\/tr><\/thead><tbody><tr><td><strong>\u03b2-\u30ab\u30ea\u30aa\u30d5\u30a3\u30ec\u30f3\uff08BCP\uff09<\/strong><\/td><td>\u30d6\u30e9\u30c3\u30af\u30da\u30c3\u30d1\u30fc\u3001\u30b3\u30d1\u30a4\u30d0<\/td><td>CB2\u2192Nrf2\/HO-1\u3001PPAR-\u03b3\uff1bTh17\u2193\u3001IL-6\u2193\u3002<\/td><td>EAE\u30e2\u30c7\u30eb<\/td><\/tr><tr><td><strong>AKBA<\/strong><\/td><td>\u30d5\u30e9\u30f3\u30ad\u30f3\u30bb\u30f3\u30b9<em>\u30dc\u30b9\u30a6\u30a7\u30ea\u30a2\u30bb\u30e9\u30fc\u30bf<\/em>)<\/td><td>STAT3\u2193\u3001NF-\u03baB\u2193\u30015-LOX\u2193\u3001SPM\u2191\u3001Nrf2\/HO-1\u2191\u3002<\/td><td>CNS\u7814\u7a76<\/td><\/tr><tr><td><strong>\u9162\u9178\u30a4\u30f3\u30bb\u30f3\u30bd\u30fc\u30eb<\/strong><\/td><td>\u30d5\u30e9\u30f3\u30ad\u30f3\u30bb\u30f3\u30b9\uff08\u63ee\u767a\u6027\u90e8\u5206\uff09<\/td><td>TRPV3\u3001PPAR-\u03b3\u3001IL-6\u2193\u3001GFAP\u2193\u3002<\/td><td>\u52d5\u7269\u30e2\u30c7\u30eb<\/td><\/tr><tr><td><strong>\u03b1-\u30a2\u30b5\u30ed\u30f3<\/strong><\/td><td>\u30ab\u30e9\u30de\u30b9<em>\u83d6\u84b2<\/em>)<\/td><td>PPAR-\u03b3 \u2192 GLT-1\u2191 \u2192 OPC\u4fdd\u8b77\u3001\u76f4\u63a5\u518d\u9ac4\u9798\u5316<\/td><td>\u4f4e\u9178\u7d20\u30e2\u30c7\u30eb<\/td><\/tr><tr><td><strong>\u30ea\u30ca\u30ed\u30fc\u30eb<\/strong><\/td><td>\u30e9\u30d9\u30f3\u30c0\u30fc\u3001\u30ec\u30e2\u30f3\u30d0\u30fc\u30e0<\/td><td>NMDA\u8abf\u7bc0\u3001SERT\u3001\u795e\u7d4c\u4fdd\u8b77<\/td><td>\u2605\u2605\u2605<\/td><\/tr><tr><td><strong>1,8-\u30b7\u30cd\u30aa\u30fc\u30eb<\/strong><\/td><td>\u30e6\u30fc\u30ab\u30ea\u3001\u30ed\u30fc\u30ba\u30de\u30ea\u30fc<\/td><td>AChE\u963b\u5bb3\u3001\u6297\u9178\u5316\u4f5c\u7528<\/td><td>\u8133\u5185\u3067\u8a3c\u660e\u3055\u308c\u305f\uff09\u2605\u2605\u2605\u2605\uff08\u8133\u5185\u3067\u8a3c\u660e\u3055\u308c\u305f<\/td><\/tr><tr><td><strong>\u30b7\u30c8\u30ed\u30cd\u30ed\u30fc\u30eb<\/strong><\/td><td>\u30bc\u30e9\u30cb\u30a6\u30e0<\/td><td>NO\u2193\u3001NF-\u03baB\u2193\u3001\u76f8\u4e57\u52b9\u679c<\/td><td>\u2605\u2605<\/td><\/tr><tr><td><strong>\u30c6\u30eb\u30d4\u30cd\u30f3-4-\u30aa\u30fc\u30eb<\/strong><\/td><td>\u30c6\u30a3\u30fc\u30c4\u30ea\u30fc<\/td><td>\u30df\u30af\u30ed\u30b0\u30ea\u30a2 M1\u2193\u3001LOX\u2193\u3001AChE\u2193\u3002<\/td><td>\u2605\u2605<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Quellen_und_weiterfuhrende_Literatur\"><\/span><strong>\u60c5\u5831\u6e90\u3068\u53c2\u8003\u6587\u732e<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Banwell B et al - Lancet Neurol.<\/strong> \u8a3a\u65ad\u57fa\u6e96 MOGAD<br><strong>PubMed\uff08\u7121\u6599\uff09\uff1a<\/strong> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36706773\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/36706773\/<\/a> <br><strong>ScienceDirect\uff08\u6284\u9332\u306f\u7121\u6599\u3001\u5168\u6587\u306f\u6709\u6599\uff09\uff1a<\/strong> <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1474442222004318\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1474442222004318<\/a> <br><strong>DOI\uff1a<\/strong> <a href=\"https:\/\/doi.org\/10.1016\/S1474-4422(22)00431-8\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1016\/S1474-4422(22)00431-8<\/a><\/li>\n\n\n\n<li><strong>Mader S et al - PNAS 2023<\/strong> <em>(\u6ce8\uff1a\u672c\u6587\u4e2d\u3067\u306f \u201ePNAS 2024 \"\u3068\u8868\u8a18\u3057\u3066\u3044\u308b\u304c\u3001\u6b63\u3057\u304f\u306f2023\u5e743\u6708\u3067\u3042\u308b\u3002\uff09<\/em> LMU\u30df\u30e5\u30f3\u30d8\u30f3\u3001\u88dc\u4f53\u5bfeFcR\u306e\u75c5\u7406\u30e1\u30ab\u30cb\u30ba\u30e0<br><strong>PNAS\u5168\u6587\uff08\u7121\u6599\uff09\uff1a<\/strong> <a href=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2300648120\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2300648120<\/a> <br><strong>LMU\u306e\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\uff08\u89e3\u8aac\u4ed8\u304d\uff09\uff1a<\/strong> <a href=\"https:\/\/www.med.lmu.de\/bmc\/en\/news\/latest-news\/news-overview\/news\/autoimmune-disease-mogad-insights-into-pathomechanisms.html\" target=\"_blank\" rel=\"noopener\">https:\/\/www.med.lmu.de\/bmc\/en\/news\/latest-news\/news-overview\/news\/autoimmune-disease-mogad-insights-into-pathomechanisms.html<\/a> <br><strong>EAN\u306e\u89e3\u8aac\uff1a<\/strong> <a href=\"https:\/\/www.ean.org\/research\/resources\/neurology-updates\/detail\/complement-dependent-and-independent-pathomechanisms-of-myelin-oligodendrocyte-glycoprotein-mog-abs-implications-for-therapeutic-strategies-in-mog-antibody-associated-disease-mogad\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.ean.org\/research\/resources\/neurology-updates\/detail\/complement-dependent-and-independent-pathomechanisms-of-myelin-oligodendrocyte-glycoprotein-mog-abs-implications-for-therapeutic-strategies-in-mog-antibody-associated-disease-mogad<\/a> <\/li>\n\n\n\n<li><strong>Kaneko K et al - Neurol Neuroimmunol Neuroinflamm.2024;11(5):e200293<\/strong> CSF\u88dc\u4f53\u6d3b\u6027\u5316<br>\u8ad6\u6587e200293\u306f <strong>\u76f4\u63a5\u306b\u306f\u898b\u3064\u304b\u3089\u306a\u3044<\/strong> - \u305f\u3060\u3057\u3001\u540c\u53f7\u306b\u63b2\u8f09\u3055\u308c\u305fMOGAD\u306e\u95a2\u9023\u7dcf\u8aac\uff08Moseley\/Zamvil\u306b\u3088\u308be200275\uff09\u306f\u5165\u624b\u53ef\u80fd\u3067\u3042\u308b\uff1a<br><strong>Neurology NXI\uff08e200275\u3001\u540c\u53f7\uff09\uff1a<\/strong> <a href=\"https:\/\/www.neurology.org\/doi\/10.1212\/NXI.0000000000200275\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.neurology.org\/doi\/10.1212\/NXI.0000000000200275<\/a> <br><strong>\u91d1\u5b502024 MOGAD CSF\u3092PubMed\u3067\u691c\u7d22\uff1a<\/strong> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38996203\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/38996203\/<\/a> <em>(e200275\u306b\u3064\u306a\u304c\u308b - e200293\u306b\u3064\u3044\u3066\u306fPubMed\u3067\u306e\u76f4\u63a5\u691c\u7d22\u3092\u63a8\u5968\uff09\u3002<\/em><\/li>\n\n\n\n<li><strong>Cho EB et al - Front Immunol.<\/strong> \u88dc\u5b8c\u30d1\u30bf\u30fc\u30f3 MOGAD\u5bfeNMOSD<br><strong>Frontiers\uff08\u5168\u6587\u7121\u6599\uff09\uff1a<\/strong> <a href=\"https:\/\/doi.org\/10.3389\/fimmu.2024.1320094\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.3389\/fimmu.2024.1320094<\/a> <em>(\u76f4\u63a5\u30a2\u30af\u30bb\u30b9\u53ef\u80fd\u306aDOI\uff09<\/em><\/li>\n\n\n\n<li><strong>Frontiers Immunol.<\/strong> <em>(\u4e00\u822c\u7684\u306b\u6587\u66f8\u3067\u8a00\u53ca\u3055\u308c\u3066\u3044\u308b\u306e\u306f\u3001\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\uff0f\u30d1\u30b9\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u95a2\u3059\u308b\u6982\u8aac\u8a18\u4e8b\u3067\u3042\u308b\uff09\u3002<\/em><br><strong>Frontiers Immunol.2025\uff08Sun\u3089\u3001PMID 40406135\uff09\uff1a<\/strong> <a href=\"https:\/\/doi.org\/10.3389\/fimmu.2025.1535571\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.3389\/fimmu.2025.1535571<\/a><\/li>\n\n\n\n<li><strong>PMC 2023 - \u75c5\u614b\u751f\u7406\u5b66\u7dcf\u8ad6 MOGAD<\/strong><br><strong>PMC\u30d5\u30eb\u30c6\u30ad\u30b9\u30c8\uff08\u7121\u6599\uff09\uff1a<\/strong> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9597055\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9597055\/<\/a><\/li>\n\n\n\n<li><strong>PMC 2024 - \u81e8\u5e8a\u75c7\u72b6\u3001\u75c5\u614b\u3001\u6cbb\u7642\u306b\u95a2\u3059\u308b\u6700\u65b0\u30ec\u30d3\u30e5\u30fc<\/strong><br><strong>PubMed\/PMC\uff08Trewin\u3089\u3001Autoimmun Rev 2025\uff09\uff1a<\/strong> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39577549\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/39577549\/<\/a><br><strong>PMC\u30d5\u30eb\u30c6\u30ad\u30b9\u30c8\uff1a<\/strong> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9294102\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9294102\/<\/a> <em>(\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u7642\u6cd5 NMOSD\/MOGAD\uff09<\/em><\/li>\n\n\n\n<li><strong>St\u00f6gbauer J et al - Autoimmunity Reviews 2025;103970<\/strong> \u6cbb\u7642\u7684\u30a2\u30d7\u30ed\u30fc\u30c1 \u6210\u4ebaMOGAD<br><strong>ScienceDirect\uff08\u30aa\u30fc\u30d7\u30f3\u30a2\u30af\u30bb\u30b9\u3001\u5168\u6587\u7121\u6599\uff09\uff1a<\/strong> <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1568997225002319\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1568997225002319<\/a> <br><strong>DOI\uff1a<\/strong> <a href=\"https:\/\/doi.org\/10.1016\/j.autrev.2025.103970\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1016\/j.autrev.2025.103970<\/a> <br><strong>\u30c9\u30a4\u30c4\u8a9e\u306e\u8981\u7d04\uff1a<\/strong> <a href=\"https:\/\/www.reine-nervensache.de\/therapieansaetze-bei-mogad-von-der-akutbehandlung-zur-langfristigen-strategie\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.reine-nervensache.de\/therapieansaetze-bei-mogad-von-der-akutbehandlung-zur-langfristigen-strategie\/<\/a> <\/li>\n\n\n\n<li><strong>\u65b0\u85ac2025\u5e74\u306b\u95a2\u3059\u308b\u5c02\u9580\u5bb6\u306e\u610f\u898b - \u81e8\u5e8a\u8a66\u9a13\u306e\u72b6\u6cc1<\/strong><br><strong>Tandfonline\uff08\u6284\u9332\u306f\u7121\u6599\u3001\u5168\u6587\u306f\u6709\u6599\uff09\uff1a<\/strong> <a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14728214.2025.2565189\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14728214.2025.2565189<\/a><br><strong>DOI\uff1a<\/strong> <a href=\"https:\/\/doi.org\/10.1080\/14728214.2025.2565189\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1080\/14728214.2025.2565189<\/a><br><\/li>\n\n\n\n<li><strong>NEMOS\u7814\u7a76\u4f1a<\/strong> <a href=\"https:\/\/www.nemos-net.de\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.nemos-net.de<\/a><br><\/li>\n\n\n\n<li><strong>\u60a3\u8005\u6307\u5411\u306e\u8a66\u9a13\u6982\u8981\uff08cosMOG\/METEOROID\uff09\uff1a<\/strong><br>MOG\u30d7\u30ed\u30b8\u30a7\u30af\u30c8 <a href=\"https:\/\/mogproject.org\/clinical-trials\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/mogproject.org\/clinical-trials\/<\/a><br>ClinicalTrials.gov - cosMOG - \u30af\u30ea\u30cb\u30ab\u30eb\u30fb\u30c8\u30e9\u30a4\u30a2\u30eb\u30ba\u30fb\u30b4\u30d6 <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05063162\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/clinicaltrials.gov\/study\/NCT05063162<\/a><\/li>\n<\/ul>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">\u3059\u3079\u3066\u306e\u5185\u5bb9\u306f\u3001\u826f\u5fc3\u7684\u306b\u8abf\u67fb\u3055\u308c\u3001\u73fe\u5728\uff082026\u5e742\u6708\uff09\u516c\u8868\u3055\u308c\u3066\u3044\u308b\u77e5\u8b58\u3092\u53cd\u6620\u3057\u305f\u3082\u306e\u3067\u3059\u3002\u3053\u308c\u306f\u60c5\u5831\u63d0\u4f9b\u306e\u307f\u3092\u76ee\u7684\u3068\u3057\u305f\u3082\u306e\u3067\u3042\u308a\u3001\u5c02\u9580\u7684\u306a\u533b\u7642\u76f8\u8ac7\u306b\u4ee3\u308f\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002.<br>\u3059\u3079\u3066\u306e\u63a8\u5968\u7528\u91cf\u306f\u3001\u4e3b\u6cbb\u533b\u3068\u5408\u610f\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3002. <br>\u30ea\u30f3\u30af\u3055\u308c\u305f\u7814\u7a76\u306f\u3001\u958b\u696d\u533b\u306b\u3055\u3089\u306a\u308b\u533b\u5b66\u7684\u30fb\u79d1\u5b66\u7684\u60c5\u5831\u3092\u63d0\u4f9b\u3059\u308b\u3002.<\/p>\n<\/blockquote>","protected":false},"excerpt":{"rendered":"<p><span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">\u8aad\u66f8\u6642\u9593<\/span> <span class=\"rt-time\"> 17<\/span> <span class=\"rt-label rt-postfix\">\u8b70\u4e8b\u9332<\/span><\/span>Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease Was ist MOGAD? Jeder kennt elektrische Leitungen: Sie sind mit einer Isolierung versehen, die die einzelne Leiter im Kableb\u00fcndel von einander trennt, damit die Signale in ihnen einander nicht st\u00f6ren und unverf\u00e4lscht von A nach B gelangen.Das R\u00fcckenmark beinhaltet einen ganzen Strang vieler solcher Kabelb\u00fcndel. Sie leiten die Nervensignale vom Gehirn zu den verschiednen Organen,Muskeln, Geweben, etc. im K\u00f6rper. W\u00e4hrend beim Kabel die Isolierung auf Kunststoffen, Textilien oder speziellen Materialien besteht, wird die Isolierschicht Myelinschicht. Was geht bei MOGAD schief? Bei MOGAD macht das eigene Immunsystem einen folgenreichen Fehler: Es produziert f\u00e4lschlicherweise Antik\u00f6rper gegen ein bestimmtes Eiwei\u00df auf der Au\u00dfenseite dieser Isolierschicht, das sog. MOG-Protein.&hellip;&nbsp;<a href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/\" rel=\"bookmark\">\u7d9a\u304d\u3092\u8aad\u3080 \"<span class=\"screen-reader-text\">MOGAD - MOG\u6297\u4f53\u95a2\u9023\u75be\u60a3<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[1078,354],"tags":[94,5721,5717,5720,5714,5713,5711,5715,5719,5716,77,90,5712,5718],"class_list":["post-12718","post","type-post","status-publish","format-standard","hentry","category-medizin","category-medizin-gesundheit","tag-antikoerper","tag-bcp","tag-glykoprotein","tag-igg","tag-mog","tag-mogad","tag-molekulare-signalwege","tag-myelin","tag-myelinscheide","tag-oligodendrozyten","tag-pathophysiologie","tag-rezeptoren","tag-therapiekonzepte","tag-transmebranprotein"],"modified_by":"Achim Goerner","_links":{"self":[{"href":"https:\/\/csiag.eu\/ja\/wp-json\/wp\/v2\/posts\/12718","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csiag.eu\/ja\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csiag.eu\/ja\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csiag.eu\/ja\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csiag.eu\/ja\/wp-json\/wp\/v2\/comments?post=12718"}],"version-history":[{"count":0,"href":"https:\/\/csiag.eu\/ja\/wp-json\/wp\/v2\/posts\/12718\/revisions"}],"wp:attachment":[{"href":"https:\/\/csiag.eu\/ja\/wp-json\/wp\/v2\/media?parent=12718"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csiag.eu\/ja\/wp-json\/wp\/v2\/categories?post=12718"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csiag.eu\/ja\/wp-json\/wp\/v2\/tags?post=12718"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}