{"id":12789,"date":"2026-02-19T18:18:00","date_gmt":"2026-02-19T18:18:00","guid":{"rendered":"https:\/\/csiag.eu\/?p=12789"},"modified":"2026-02-21T06:07:24","modified_gmt":"2026-02-21T06:07:24","slug":"%e5%85%8d%e7%96%ab%e7%b4%b0%e8%83%9e%e7%99%82%e6%b3%95","status":"publish","type":"post","link":"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/","title":{"rendered":"\u514d\u75ab\u7d30\u80de\u7642\u6cd5"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u76ee\u6b21<\/p>\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Das_Immunsystem_%E2%80%93_was_macht_das\" >\u514d\u75ab\u30b7\u30b9\u30c6\u30e0 - \u305d\u306e\u50cd\u304d\u3068\u306f\uff1f<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Was_Immunzelltherapie_macht\" >\u514d\u75ab\u7d30\u80de\u7642\u6cd5\u306f\u4f55\u3092\u3059\u308b\u306e\u304b<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Das_Geniale_daran\" >\u305d\u306e\u5929\u624d<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Die_drei_Typen_%E2%80%93_ganz_einfach\" >3\u3064\u306e\u30bf\u30a4\u30d7 - \u975e\u5e38\u306b\u30b7\u30f3\u30d7\u30eb<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#T-Zellen_und_ihre_Rolle\" >T\u7d30\u80de\u3068\u305d\u306e\u5f79\u5272<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Tumorimmunologie-Grundprinzip\" >\u816b\u760d\u514d\u75ab\u5b66\u306e\u57fa\u672c\u539f\u7406<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#CAR-T-Zelltherapie_%E2%80%93_Konstruktion_und_Mechanismus\" >CAR-T\u7d30\u80de\u7642\u6cd5 - \u30c7\u30b6\u30a4\u30f3\u3068\u30e1\u30ab\u30cb\u30ba\u30e0<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Molekularer_Aufbau_des_CAR\" >CAR\u306e\u5206\u5b50\u69cb\u9020<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Herstellungsprozess_Autolog\" >\u88fd\u9020\u5de5\u7a0b\uff08\u30aa\u30fc\u30c8\u30ed\u30fc\u30b0\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Wirkmechanismus_Effektorphase\" >\u4f5c\u7528\u6a5f\u5e8f\u3068\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u76f8<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#TCR-T-Zelltherapie_Die_entscheidenden_Unterschiede\" >TCR-T\u7d30\u80de\u7642\u6cd5\uff1a\u91cd\u8981\u306a\u9055\u3044<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Warum_TCR_und_nicht_CAR_fur_intrazellulare_Antigene\" >\u306a\u305c\u7d30\u80de\u5185\u6297\u539f\u306b\u306fCAR\u3067\u306f\u306a\u304fTCR\u306a\u306e\u304b\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Struktur_des_therapeutischen_TCR\" >\u6cbb\u7642\u7528TCR\u306e\u69cb\u9020<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#TIL-Therapie_%E2%80%93_Prinzip_der_naturlichen_Tumorerkennung\" >TIL\u7642\u6cd5-\u81ea\u7136\u816b\u760d\u691c\u51fa\u306e\u539f\u7406<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Biologische_Grundlage\" >\u751f\u7269\u5b66\u7684\u57fa\u790e<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Herstellungsprozess_Lifileucel\" >\u88fd\u9020\u5de5\u7a0b\uff08\u30ea\u30d5\u30a3\u30ea\u30e5\u30fc\u30bb\u30eb\uff09<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Herausforderungen_%E2%80%93_aktuelle_Forschungsansatze\" >\u8ab2\u984c - \u73fe\u5728\u306e\u7814\u7a76\u30a2\u30d7\u30ed\u30fc\u30c1<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Antigen-Escape\" >\u6297\u539f\u30a8\u30b9\u30b1\u30fc\u30d7<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#T-Zell-Erschopfung_Exhaustion\" >T\u7d30\u80de\u6d88\u8017\uff08\u75b2\u5f0a\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Tumormikroumgebung_TME\" >\u816b\u760d\u5fae\u5c0f\u74b0\u5883\uff08TME\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Zytokinsturm_CRS_ICANS\" >\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30b9\u30c8\u30fc\u30e0\uff08CRS\uff09\u3068ICANS<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Allogene_%E2%80%9EOff-the-shelf%E2%80%9C-Therapien\" >\u540c\u7a2e\u300c\u65e2\u88fd\u300d\u7642\u6cd5<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#27_Quantitative_Wirksamkeitsdaten_im_Uberblick\" >2.7 \u5b9a\u91cf\u7684\u6709\u52b9\u6027\u30c7\u30fc\u30bf\u4e00\u89a7<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Weiterfuhrende_Literatur_Ressourcen\" >\u305d\u306e\u4ed6\u306e\u8cc7\u6599<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Weltweit_zugelassene_Immunzelltherapien\" >\u4e16\u754c\u7684\u306b\u627f\u8a8d\u3055\u308c\u305f\u514d\u75ab\u7d30\u80de\u7642\u6cd5<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-26\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Einleitung_Die_drei_grosen_Klassen\" >\u306f\u3058\u3081\u306b\uff1a3\u3064\u306e\u4e3b\u8981\u30af\u30e9\u30b9<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-27\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#CAR-T-ZELLTHERAPIEN\" >\u30ab\u30fcT\u7d30\u80de\u7642\u6cd5<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-28\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Tisagenlecleucel_Kymriah%C2%AE_%E2%80%93_Novartis\" >Tisagenlecleucel\uff08Kymriah\u00ae\uff09-\u30ce\u30d0\u30eb\u30c6\u30a3\u30b9<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-29\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Axicabtagene_Ciloleucel_Yescarta%C2%AE_%E2%80%93_KiteGilead\" >\u30a2\u30af\u30b7\u30ab\u30d6\u30bf\u30b8\u30a7\u30f3\u30fb\u30b7\u30ed\u30ed\u30a4\u30bb\u30eb\uff08\u30a4\u30a8\u30b9\u30ab\u30eb\u30bf\u00ae\uff09 - \u30ab\u30a4\u30c8\uff0f\u30ae\u30ea\u30a2\u30c9\u793e<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-30\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Brexucabtagene_Autoleucel_Tecartus%C2%AE_%E2%80%93_KiteGilead\" >Brexucabtagene Autoleucel\uff08Tecartus\u00ae\uff09-\u30ab\u30a4\u30c8\uff0f\u30ae\u30ea\u30a2\u30c9\u793e<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-31\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Lisocabtagene_Maraleucel_Breyanzi%C2%AE_%E2%80%93_Bristol_Myers_Squibb\" >\u30ea\u30be\u30ab\u30d6\u30bf\u30b8\u30a7\u30f3\u30fb\u30de\u30e9\u30ec\u30a6\u30bb\u30eb\uff08\u30d6\u30ea\u30a2\u30f3\u30b8\u00ae\uff09 - \u30d6\u30ea\u30b9\u30c8\u30eb\u30fb\u30de\u30a4\u30e4\u30fc\u30ba \u30b9\u30af\u30a4\u30d6<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-32\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Idecabtagene_Vicleucel_Abecma%C2%AE_%E2%80%93_Bristol_Myers_Squibb_2seventy_bio\" >\u30a4\u30c7\u30ab\u30d6\u30bf\u30b8\u30a7\u30f3\u30fb\u30d3\u30af\u30ea\u30e5\u30fc\u30bb\u30eb\uff08\u30a2\u30d9\u30af\u30de\u00ae\uff09 - \u30d6\u30ea\u30b9\u30c8\u30eb\u30fb\u30de\u30a4\u30e4\u30fc\u30ba \u30b9\u30af\u30a4\u30d6 \/ 2seventy bio<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-33\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Ciltacabtagene_Autoleucel_Carvykti%C2%AE_%E2%80%93_JanssenLegend_Biotech\" >Ciltacabtagene Autoleucel (Carvykti\u00ae) - \u30e4\u30f3\u30bb\u30f3\/\u30ec\u30b8\u30a7\u30f3\u30c9\u30fb\u30d0\u30a4\u30aa\u30c6\u30c3\u30af<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-34\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Obecabtagene_Autoleucel_Aucatzyl%C2%AE_%E2%80%93_Autolus_neu_112024\" >\u30aa\u30d9\u30ab\u30d6\u30bf\u30b8\u30a7\u30f3\u30cc\u30fb\u30aa\u30fc\u30c8\u30ea\u30e5\u30fc\u30bb\u30eb (Aucatzyl\u00ae) - Autolus (new: 11.2024)<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-35\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#WELTWEIT_ZUGELASSEN_%E2%80%93_NICHT_IN_USAEU_weitere_Lander\" >\u30ef\u30fc\u30eb\u30c9\u30ef\u30a4\u30c9\u3067\u4f7f\u7528\u53ef\u80fd - USA\/EU\uff08\u305d\u306e\u4ed6\u306e\u56fd\uff09\u3067\u306f\u4f7f\u7528\u4e0d\u53ef<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-36\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#China_NMPA_%E2%80%93_vier_zusatzliche_CAR-T-Produkte\" >\u4e2d\u56fd\uff08NMPA\uff09-4\u3064\u306eCAR-T\u88fd\u54c1\u304c\u8ffd\u52a0\u3055\u308c\u308b<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-37\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Indien_CDSCO\" >\u30a4\u30f3\u30c9\uff08CDSCO\uff09<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-38\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#TCR-T-ZELLTHERAPIEN_zugelassen\" >TCR-T\u7d30\u80de\u7642\u6cd5\uff08\u516c\u8a8d\uff09<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-39\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Afamitresgene_Autoleucel_Tecelra%C2%AE_%E2%80%93_Adaptimmune_August_2024\" >\u30a2\u30d5\u30a1\u30df\u30c8\u30ec\u30b9\u907a\u4f1d\u5b50\u30aa\u30fc\u30c8\u30ed\u30a4\u30bb\u30eb\uff08\u30c6\u30bb\u30eb\u30e9\u00ae\uff09 - \u30a2\u30c0\u30d7\u30c6\u30a3\u30df\u30e5\u30fc\u30f3\uff082024\u5e748\u6708\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-40\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Tebentafusp-tebn_Kimmtrak%C2%AE_%E2%80%93_Immunocore_Januar_2022\" >Tebentafusp-tebn (Kimmtrak\u00ae) - \u30a4\u30e0\u30ce\u30b3\u30a2 (2022\u5e741\u6708)<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-41\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#TIL-THERAPIE_zugelassen\" >TIL-THERAPY\uff08\u8a8d\u53ef\u6e08\u307f\uff09<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-42\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Lifileucel_Amtagvi%C2%AE_%E2%80%93_Iovance_Biotherapeutics_Februar_2024\" >Lifileucel (Amtagvi\u00ae) - Iovance Biotherapeutics (2024\u5e742\u6708)<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-43\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Ubersicht_aller_Immunzelltherapien_weltweit\" >\u5168\u4e16\u754c\u306e\u514d\u75ab\u7d30\u80de\u6cbb\u7642\u306e\u6982\u8981<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-44\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Nebenwirkungen_%E2%80%93_Was_alle_Therapien_verbindet\" >\u526f\u4f5c\u7528-\u3059\u3079\u3066\u306e\u7642\u6cd5\u306b\u5171\u901a\u3059\u308b\u3082\u306e<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-45\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Wo_werden_diese_Therapien_in_Deutschland_angeboten\" >\u30c9\u30a4\u30c4\u3067\u306f\u3069\u306e\u3088\u3046\u306a\u6cbb\u7642\u304c\u884c\u308f\u308c\u3066\u3044\u308b\u306e\u3067\u3059\u304b\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-46\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Ausblick_Was_kommt_als_nachstes\" >\u5c55\u671b\uff1a\u6b21\u306e\u5c55\u671b\u306f\uff1f<\/a><\/li><\/ul><\/li>\u3002<li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-47\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#GKV-Erstattung_von_Immunzelltherapien_in_Deutschland\" >\u30c9\u30a4\u30c4\u306b\u304a\u3051\u308b\u514d\u75ab\u7d30\u80de\u6cbb\u7642\u306eSHI\u511f\u9084<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-48\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#CAR-T-Zelltherapien\" >CAR-T\u7d30\u80de\u7642\u6cd5<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-49\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#AMNOG_NUB-Verfahren\" >AMNOG\u3068NUB\u306e\u624b\u9806<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-50\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Fruhe_Nutzenbewertung_durch_den_G-BA\" >G-BA\u306b\u3088\u308b\u65e9\u671f\u5229\u76ca\u67fb\u5b9a<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-51\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Preisverhandlung_nach_%C2%A7_130b_SGB_V\" >SGB\u7b2c130b\u6761\u306b\u57fa\u3065\u304f\u4fa1\u683c\u4ea4\u6e09 V<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-52\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#NUB-Verfahren_fur_Krankenhauser\" >\u75c5\u9662\u306eNUB\u624b\u7d9a\u304d<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-53\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Die_Realitat_Einzelfallantrage_und_Burokratie\" >\u73fe\u5b9f\uff1a\u500b\u5225\u306e\u7533\u8acb\u3068\u5b98\u50da\u4e3b\u7fa9<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-54\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Das_%E2%80%9EPay-for-Outcome%E2%80%9C-Modell\" >\u6210\u679c\u5831\u916c\u300d\u30e2\u30c7\u30eb<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-55\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Welche_CAR-T-Produkte_sind_in_Deutschland_erstattungsfahig\" >\u30c9\u30a4\u30c4\u3067\u306f\u3001\u3069\u306eCAR-T\u88fd\u54c1\u304c\u4fdd\u967a\u511f\u9084\u306e\u5bfe\u8c61\u3068\u306a\u308a\u307e\u3059\u304b\uff1f<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-56\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Kimmtrak_Tebentafusp_%E2%80%93_Sonderfall\" >\u30ad\u30e0\u30c8\u30e9\u30c3\u30af\uff08\u30c6\u30d9\u30f3\u30bf\u30d5\u30b9\u30d7\uff09 - \u7279\u5225\u306a\u30b1\u30fc\u30b9<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-57\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#TIL-Therapie_Lifileucel_Amtagvi_%E2%80%93_In_Deutschland_derzeit_NICHT_erstattungsfahig\" >TIL\u7642\u6cd5\uff08Lifileucel\/Amtagvi\uff09 - \u73fe\u5728\u30c9\u30a4\u30c4\u3067\u306f\u4fdd\u967a\u511f\u9084\u3055\u308c\u3066\u3044\u306a\u3044\u3002<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-58\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#TCR-T-Therapien_Afami-cel_Tecelra_%E2%80%93_In_Europa_nicht_zugelassen\" >TCR-T\u7642\u6cd5\uff08Afami-cel \/ Tecelra\uff09 - \u6b27\u5dde\u3067\u306f\u672a\u627f\u8a8d<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-59\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Was_tun_wenn_die_Kasse_ablehnt_Rechtliche_Moglichkeiten\" >\u4fdd\u967a\u4f1a\u793e\u306b\u65ad\u3089\u308c\u305f\u3089\u3069\u3046\u3059\u308b\uff1f\u6cd5\u7684\u9078\u629e\u80a2<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-60\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Osterreich\" >\u30aa\u30fc\u30b9\u30c8\u30ea\u30a2<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-61\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Schweiz\" >\u30b9\u30a4\u30b9<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-62\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Zusammenfassung\" >\u6982\u8981<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-63\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#PKV_und_Immunzelltherapie_%E2%80%93_Die_vollstandige_Rechtslage\" >PKV\u3068\u514d\u75ab\u7d30\u80de\u7642\u6cd5-\u5b8c\u5168\u306a\u6cd5\u7684\u72b6\u6cc1<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-64\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Das_rechtliche_Fundament_%C2%A7_192_VVG_und_MBKK_2009\" >\u6cd5\u7684\u6839\u62e0\uff1aVVG192\u6761\u304a\u3088\u3073MB\/KK2009\u6761<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-65\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Der_Schlusselbegriff_%E2%80%9EMedizinisch_notwendige_Heilbehandlung%E2%80%9C\" >\u30ad\u30fc\u30ef\u30fc\u30c9\u306f \u201e\u533b\u5b66\u7684\u306b\u5fc5\u8981\u306a\u6cbb\u7642\u201c<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-66\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Das_Richtungsurteil_OLG_Frankfurt_29062022_%E2%80%93_Az_7_U_14021\" >\u753b\u671f\u7684\u306a\u5224\u6c7a\uff1a \u30d5\u30e9\u30f3\u30af\u30d5\u30eb\u30c8\u9ad8\u7b49\u5f01\u52d9\u5b98\u4e8b\u52d9\u6240\u30012022\u5e746\u670829\u65e5-\u5be9\u5224\u756a\u53f77 U 140\/21<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-67\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Das_%E2%80%9Eauffallige_Missverhaltnis%E2%80%9C_nach_%C2%A7_192_Abs_2_VVG_%E2%80%93_und_warum_es_bei_CAR-T_nicht_greift\" >VVG\u7b2c192\u6761\u7b2c2\u9805\u306b\u3088\u308b\u300c\u9855\u8457\u306a\u4e0d\u91e3\u308a\u5408\u3044\u300d-CAR-T\u306b\u9069\u7528\u3055\u308c\u306a\u3044\u7406\u7531<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-68\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Das_Voranfrageverfahren_nach_%C2%A7_192_Abs_8_VVG_%E2%80%93_der_wichtigste_praktische_Schritt\" >VVG\u7b2c192\u6761(8)\u306b\u5f93\u3063\u305f\u4e88\u5099\u8abf\u67fb\u624b\u7d9a\u304d-\u6700\u3082\u91cd\u8981\u306a\u5b9f\u52d9\u30b9\u30c6\u30c3\u30d7<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-69\" href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/#Bei_Ablehnung_Rechtsmittel_und_Klage\" >\u4e0d\u5408\u683c\u306e\u5834\u5408\uff1a\u7570\u8b70\u7533\u3057\u7acb\u3066\u3068\u6cd5\u7684\u63aa\u7f6e<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">\u8aad\u66f8\u6642\u9593<\/span> <span class=\"rt-time\"> 20<\/span> <span class=\"rt-label rt-postfix\">\u8b70\u4e8b\u9332<\/span><\/span>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Das_Immunsystem_%E2%80%93_was_macht_das\"><\/span>\u514d\u75ab\u30b7\u30b9\u30c6\u30e0 - \u305d\u306e\u50cd\u304d\u3068\u306f\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u514d\u75ab\u7cfb\u306f\u3001\u65a5\u5019\u3084\u6226\u95d8\u54e1(<em>T\u7d30\u80de<\/em>)\u3068\u30d8\u30eb\u30d1\u30fc\u3067\u3042\u308b\u3002\u5f7c\u3089\u306f\u5e38\u306b\u4f53\u5185\u3092\u30d1\u30c8\u30ed\u30fc\u30eb\u3057\u3001\u7d30\u83cc\u3084\u30a6\u30a4\u30eb\u30b9\u306a\u3069\u306e\u4fb5\u5165\u8005\u3092\u63a2\u3059\u3060\u3051\u3067\u306a\u304f\u3001\u66b4\u8d70\u3057\u305f\u4f53\u5185\u306e\u7d30\u80de\u3001\u3064\u307e\u308a\u30ac\u30f3\u7d30\u80de\u3082\u63a2\u3059\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u901a\u5e38\u3001\u3053\u306e\u3088\u3046\u306a\u66b4\u308c\u307e\u308f\u308b\u7d30\u80de\u306f\u3001\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u306e\u756a\u4eba\u306b\u3088\u3063\u3066\u3059\u3050\u306b\u767a\u898b\u3055\u308c\u3001\u6bba\u3055\u308c\u3001\u305d\u306e\u6b8b\u9ab8\u306f\u53d6\u308a\u9664\u304b\u308c\u3066\u5206\u89e3\u3055\u308c\u308b\u3002\u3053\u308c\u306f\u6bce\u65e5\u7d76\u3048\u9593\u306a\u304f\u884c\u308f\u308c\u3066\u3044\u308b\u3002\u3053\u3046\u3057\u3066\u3001\u307b\u3068\u3093\u3069\u306e\u304c\u3093\u7d30\u80de\u306f\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u306b\u3088\u3063\u3066\u62e1\u6563\u3092\u963b\u6b62\u3055\u308c\u3001\u307b\u3069\u306a\u304f\u7121\u5bb3\u5316\u3055\u308c\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u304b\u3057\u3001\u304c\u3093\u7d30\u80de\u306f\u4f55\u3068\u3057\u3066\u3082\u751f\u304d\u5ef6\u3073\u3088\u3046\u3068\u3059\u308b\u305f\u3081\u3001\u5275\u610f\u5de5\u592b\u3092\u51dd\u3089\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u81ea\u3089\u3092\u30ab\u30e2\u30d5\u30e9\u30fc\u30b8\u30e5\u3057\u3001\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u306e\u5b88\u8b77\u8005\u304b\u3089\u52b9\u679c\u7684\u306b\u8eab\u3092\u96a0\u3057\u3001\u307b\u3068\u3093\u3069\u6b6f\u6b62\u3081\u3092\u304b\u3051\u305a\u306b\u5e83\u304c\u308a\u7d9a\u3051\u308b\u3002\u6575\u3067\u3042\u308b\u3053\u3068\u3092\u8a8d\u8b58\u3055\u305b\u306a\u3044\u3060\u3051\u3067\u306a\u304f\u3001\u514d\u75ab\u7cfb\u3092\u5fd9\u3057\u304f\u3055\u305b\u308b\u306e\u3067\u3001\u3042\u308b\u6642\u671f\u304c\u904e\u304e\u308b\u3068\u3001\u514d\u75ab\u7cfb\u306f\u75b2\u5f0a\u3057\u3001\u7fbd\u3092\u4f38\u3070\u3055\u3056\u308b\u3092\u5f97\u306a\u304f\u306a\u308a\u3001\u304c\u3093\u306b\u5c48\u3059\u308b\u3053\u3068\u3055\u3048\u3042\u308b\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Was_Immunzelltherapie_macht\"><\/span>\u514d\u75ab\u7d30\u80de\u7642\u6cd5\u306f\u4f55\u3092\u3059\u308b\u306e\u304b<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u514d\u75ab\u7d30\u80de\u7642\u6cd5\u3067\u306f\u3001\u514d\u75ab\u7d30\u80de\u306f\u60a3\u8005\u304b\u3089\u53d6\u308a\u51fa\u3055\u308c\u3001\u3088\u308a\u512a\u308c\u305f\u8a8d\u8b58\u6280\u8853\u3001\u3088\u308a\u9ad8\u3044\u6226\u95d8\u529b\u3001\u3042\u308b\u3044\u306f\u65b0\u3057\u3044\u300c\u6a19\u7684\u5149\u5b66\u7cfb\u300d\u306a\u3069\u3092\u5099\u3048\u3001\u4f53\u5185\u306b\u623b\u3055\u308c\u308b\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Das_Geniale_daran\"><\/span>\u305d\u306e\u5929\u624d<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u5316\u5b66\u7642\u6cd5\u306f\u539f\u5247\u7684\u306b\u5206\u88c2\u306e\u65e9\u3044\u3082\u306e\u3059\u3079\u3066\uff08\u304c\u3093\u7d30\u80de\u3060\u3051\u3067\u306a\u304f\u3001\u6bdb\u6bcd\u7d30\u80de\u3084\u8178\u7ba1\u7d30\u80de\u306a\u3069\uff09\u3092\u6bba\u3059\u304c\u3001\u514d\u75ab\u7d30\u80de\u7642\u6cd5\u306f\u6b21\u306e\u3088\u3046\u306a\u3082\u306e\u3092\u6a19\u7684\u306b\u3059\u308b\u3002 <strong>\u304c\u3093\u7d30\u80de\u306e\u307f<\/strong> - \u5c11\u306a\u304f\u3068\u3082\u7406\u8ad6\u4e0a\u306f\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u514d\u75ab\u7cfb\u306f\u8a8d\u8b58\u3057\u305f\u6575\u3092\u8a18\u61b6\u3057\u3066\u3044\u308b\u306e\u3067\u3001\u304c\u3093\u304c\u518d\u767a\u3057\u305f\u5834\u5408\u3001\u3059\u3050\u306b\u65b0\u3057\u3044\u304c\u3093\u7d30\u80de\u3092\u653b\u6483\u3057\u3001\u7834\u58ca\u3059\u308b\u3002\u3053\u306e\u305f\u3081\u30011\u56de\u306e\u70b9\u6ef4\u3067\u6c38\u4e45\u306b\u816b\u760d\u306e\u306a\u3044\u72b6\u614b\u304c\u7d9a\u304f\u60a3\u8005\u3082\u3044\u308b\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Die_drei_Typen_%E2%80%93_ganz_einfach\"><\/span>3\u3064\u306e\u30bf\u30a4\u30d7 - \u975e\u5e38\u306b\u30b7\u30f3\u30d7\u30eb<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1.CAR-T\u7d30\u80de\uff1a\u5909\u63db<\/strong><br>T\u7d30\u80de\uff08\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u306e\u6226\u95d8\u529b\uff09\u3092\u63a1\u53d6\u3057\u3001\u5b9f\u9a13\u5ba4\u3067\u307e\u3063\u305f\u304f\u65b0\u3057\u3044 \u201e\u3064\u304b\u307f\u8155\u201c\u3001\u4eba\u5de5\u30ec\u30bb\u30d7\u30bf\u30fc\u3092\u7d44\u307f\u8fbc\u3080\u3002\u3053\u306e\u30ec\u30bb\u30d7\u30bf\u30fc\u306f\u304c\u3093\u7d30\u80de\u8868\u9762\u306e\u975e\u5e38\u306b\u7279\u7570\u7684\u306a\u7279\u5fb4\u3092\u8a8d\u8b58\u3057\u3001\u304c\u3093\u7d30\u80de\u3092\u76f4\u63a5\u7834\u58ca\u3059\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>2 TCR T\u7d30\u80de\uff1a\u3088\u308a\u826f\u3044\u30e1\u30ac\u30cd<\/strong><br>CAR-T\u3068\u540c\u69d8\u306b\u3001T\u7d30\u80de\u306f\u4eba\u5de5\u7684\u306a\u30b0\u30ea\u30c3\u30d1\u30fc\u30a2\u30fc\u30e0\u306e\u4ee3\u308f\u308a\u306b\u3001\u6539\u826f\u3055\u308c\u305f\u5929\u7136\u306e\u30ec\u30bb\u30d7\u30bf\u30fc\u3092\u4e0e\u3048\u3089\u308c\u3001\u305d\u306e\u30ec\u30bb\u30d7\u30bf\u30fc\u306f\u3001T\u7d30\u80de\u306e\u6df1\u3044\u7279\u5fb4\u3082\u8a8d\u8b58\u3059\u308b\u3002 <em>\u5185\u90e8<\/em> \u304c\u3093\u7d30\u80de\u306e\u5916\u304b\u3089\u306f\u5c0f\u3055\u306a\u65ad\u7247\u3057\u304b\u898b\u3048\u306a\u3044\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7b2c3\u56deTIL\u7642\u6cd5\uff1a\u30d9\u30c6\u30e9\u30f3<\/strong><br>\u3053\u3053\u3067\u306f\u3001\u3059\u3067\u306b\u3042\u308bT\u7d30\u80de\u3092\u63a1\u53d6\u3059\u308b\u3002 <em>\u816b\u760d\u305d\u306e\u3082\u306e\u306b<\/em> \u305d\u3057\u3066\u5f7c\u3092\u77e5\u308b\u3002\u5f7c\u3089\u306f\u62bd\u51fa\u3055\u308c\u3001\u5b9f\u9a13\u5ba4\u3067\u5927\u91cf\u306b\u5897\u6b96\u3055\u305b\u3089\u308c\u3001\u6570\u500b\u306e\u7d30\u80de\u304c\u6570\u5341\u5104\u500b\u306b\u306a\u308a\u3001\u7d4c\u9a13\u8c4a\u5bcc\u306a \u201e\u30d9\u30c6\u30e9\u30f3 \u201c\u306b\u9001\u308a\u8fd4\u3055\u308c\u308b\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"T-Zellen_und_ihre_Rolle\"><\/span>T\u7d30\u80de\u3068\u305d\u306e\u5f79\u5272<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u9069\u5fdc\u514d\u75ab\u7cfb\u306f\u30012\u3064\u306e\u4e3b\u8981\u306a\u7d30\u80de\u30bf\u30a4\u30d7\u306b\u57fa\u3065\u3044\u3066\u3044\u308b\uff1a <strong>B\u7d30\u80de<\/strong> (\u6297\u4f53\u7523\u751f\uff09\u3068 <strong>T\u7d30\u80de<\/strong> (\u7d30\u80de\u6027\u514d\u75ab\uff09\u3002T\u7d30\u80de\u306f2\u3064\u306e\u6a5f\u80fd\u7684\u96c6\u56e3\u306b\u5206\u3051\u3089\u308c\u3001\u3059\u3079\u3066\u306e\u514d\u75ab\u7d30\u80de\u7642\u6cd5\u306b\u4e3b\u306b\u95a2\u4fc2\u3057\u3066\u3044\u308b\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>CD8+\u7d30\u80de\u50b7\u5bb3\u6027T\u7d30\u80de\uff08CTL\uff09<\/strong><br>T\u7d30\u80de\u53d7\u5bb9\u4f53\uff08TCR\uff09\u3092\u4ecb\u3057\u3066\u611f\u67d3\u7d30\u80de\u3084\u60aa\u6027\u7d30\u80de\u306e\u8868\u9762\u306b\u3042\u308b\u30da\u30d7\u30c1\u30c9-MHC\u30af\u30e9\u30b9I\u8907\u5408\u4f53\u3092\u8a8d\u8b58\u3057\u3001\u30d1\u30fc\u30d5\u30a9\u30ea\u30f3\uff0f\u30b0\u30e9\u30f3\u30b6\u30a4\u30e0B\u306e\u653e\u51fa\u3084FasL\uff0fFas\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u901a\u3058\u3066\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u8a98\u5c0e\u3059\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>CD4+\u30d8\u30eb\u30d1\u30fcT\u7d30\u80de<\/strong><br>\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u5206\u6ccc\uff08IL-2\u3001IFN-\u03b3\u3001TNF-\u03b1\uff09\u3092\u4ecb\u3057\u3066\u514d\u75ab\u5fdc\u7b54\u3092\u8abf\u6574\u3057\u3001CTL\u5fdc\u7b54\u306e\u9577\u671f\u6301\u7d9a\u306b\u4e0d\u53ef\u6b20\u3067\u3042\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u79d1\u5b66\u7684\u6839\u62e0\u304c\u3042\u308b\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>T\u7d30\u80de\u514d\u75ab\u5b66\u306e\u57fa\u790e\u7814\u7a76\uff1a <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK10757\/\" target=\"_blank\" rel=\"noopener\">\u30b8\u30a7\u30a4\u30f3\u30a6\u30a7\u30a4\u306e\u514d\u75ab\u751f\u7269\u5b66 (NCBI Bookshelf)<\/a><\/li>\n\n\n\n<li>\u764c\u306b\u304a\u3051\u308bT\u7d30\u80de\u75b2\u5f0a\u306e\u6982\u8981\uff1a <a href=\"https:\/\/www.nature.com\/articles\/nri3862\" target=\"_blank\" rel=\"noopener\">Wherry &amp; Kurachi, Nature Reviews Immunology 2015<\/a><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Tumorimmunologie-Grundprinzip\"><\/span>\u816b\u760d\u514d\u75ab\u5b66\u306e\u57fa\u672c\u539f\u7406<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u304c\u3093\u306f\u514d\u75ab\u5b66\u7684\u7a7a\u767d\u306e\u4e2d\u3067\u767a\u751f\u3059\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u3002\u305d\u306e <strong>\u304c\u3093\u514d\u75ab\u7de8\u96c6<\/strong>-\u6982\u5ff5\uff08Dunn, Bruce &amp; Schreiber, 2004\uff09\u306f\u30013\u3064\u306e\u6bb5\u968e\u3092\u8aac\u660e\u3057\u3066\u3044\u308b\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6392\u9664<\/strong><br>\u514d\u75ab\u7cfb\u306f\u816b\u760d\u95a2\u9023\u6297\u539f\uff08TAA\uff09\u3068\u816b\u760d\u7279\u7570\u7684\u6297\u539f\uff08TSA\uff09\u3092\u4ecb\u3057\u3066\u5f62\u8cea\u8ee2\u63db\u7d30\u80de\u3092\u8a8d\u8b58\u3057\u7834\u58ca\u3059\u308b\u3002MHC-I\u3092\u4ecb\u3057\u305f\u5909\u7570\u30da\u30d7\u30c1\u30c9\u306e\u63d0\u793a\u306fCTL\u3092\u6d3b\u6027\u5316\u3059\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5747\u8861<\/strong><br>\u514d\u75ab\u7cfb\u306f\u816b\u760d\u306e\u5897\u6b96\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u4fdd\u3064\u304c\u3001\u540c\u6642\u306b\u514d\u75ab\u62b5\u6297\u6027\u306e\u5909\u7570\u4f53\u3092\u9078\u629e\u3059\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30a8\u30b9\u30b1\u30fc\u30d7<\/strong><br>\u304c\u3093\u7d30\u80de\u306f\u3001MHC-I\u306e\u30c0\u30a6\u30f3\u30ec\u30ae\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3001\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\uff08PD-L1\u3001CTLA-4\u30ea\u30ac\u30f3\u30c9\uff09\u306e\u904e\u5270\u767a\u73fe\u3001\u514d\u75ab\u6291\u5236\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08TGF-\u03b2\u3001IL-10\uff09\u306e\u5206\u6ccc\u3001\u5236\u5fa1\u6027T\u7d30\u80de\uff08Tregs\uff09\u306e\u30ea\u30af\u30eb\u30fc\u30c8\u30e1\u30f3\u30c8\u3092\u901a\u3058\u3066\u9003\u907f\u3059\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u79d1\u5b66\u7684\u6839\u62e0\u304c\u3042\u308b\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(02)00272-3\" target=\"_blank\" rel=\"noopener\">Dunn et al, Immunity 2002<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(13)00272-X\" target=\"_blank\" rel=\"noopener\">Chen &amp; Mellman, Immunity 2013 - \u304c\u3093\u514d\u75ab\u30b5\u30a4\u30af\u30eb<\/a><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"CAR-T-Zelltherapie_%E2%80%93_Konstruktion_und_Mechanismus\"><\/span>CAR-T\u7d30\u80de\u7642\u6cd5 - \u30c7\u30b6\u30a4\u30f3\u3068\u30e1\u30ab\u30cb\u30ba\u30e0<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Molekularer_Aufbau_des_CAR\"><\/span>CAR\u306e\u5206\u5b50\u69cb\u9020<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u30ad\u30e1\u30e9\u6297\u539f\u53d7\u5bb9\u4f53\uff08CAR\uff09\u306f\u30014\u3064\u306e\u6a5f\u80fd\u30c9\u30e1\u30a4\u30f3\u3092\u6301\u3064\u5408\u6210\u819c\u8cab\u901a\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1. \u7d30\u80de\u5916\u7d50\u5408\u30c9\u30e1\u30a4\u30f3<\/strong><br>\u307b\u3068\u3093\u3069 <strong>scFv<\/strong> (\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u306e\u4e00\u672c\u9396\u53ef\u5909\u65ad\u7247\uff09\u3002MHC\u975e\u4f9d\u5b58\u7684\u306b\u8868\u9762\u6297\u539f\uff08B\u7d30\u80de\u306eCD19\u3001\u5f62\u8cea\u7d30\u80de\u306eBCMA\u306a\u3069\uff09\u306b\u76f4\u63a5\u7d50\u5408\u3059\u308b\u3002\u3053\u306eMHC\u975e\u4f9d\u5b58\u6027\u304c\u5929\u7136\u306eTCR\u3068\u306e\u6839\u672c\u7684\u306a\u9055\u3044\u3067\u3042\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>2. \u30d2\u30f3\u30b8\uff0f\u30ea\u30f3\u30ab\u30fc\u9818\u57df<\/strong><br>\u7d50\u5408\u30c9\u30e1\u30a4\u30f3\u3068\u7d30\u80de\u819c\u306e\u9593\u306b\u3042\u308b\u67d4\u8edf\u306a\u30b9\u30da\u30fc\u30b5\u30fc\uff08\u4f8b\uff1aIgG4-Hinge\u3001CD8\u03b1-Hinge\uff09\u3002\u9577\u3055\u3068\u67d4\u8edf\u6027\u306f\u7d50\u5408\u52b9\u7387\u306b\u5f37\u304f\u5f71\u97ff\u3059\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>3. \u819c\u8cab\u901a\u30c9\u30e1\u30a4\u30f3<\/strong><br>CAR\u3092T\u7d30\u80de\u819c\u306b\u56fa\u5b9a\u3057\u3001\u30b7\u30b0\u30ca\u30eb\u306e\u5b89\u5b9a\u6027\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>4. \u7d30\u80de\u5185\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30c9\u30e1\u30a4\u30f3<\/strong><br>\u4e00\u6b21\u6d3b\u6027\u5316\u30c9\u30e1\u30a4\u30f3\uff083\u3064\u306eITAM\u3092\u6301\u3064CD3\u03b6\uff09\u3068\u5171\u523a\u6fc0\u6027\u30c9\u30e1\u30a4\u30f3\u304b\u3089\u306a\u308b\u3002\u5171\u523a\u6fc0\u30c9\u30e1\u30a4\u30f3\u306f <strong>CAR\u4e16\u4ee3\uff1a<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u4e16\u4ee3<\/th><th>\u5171\u523a\u6fc0<\/th><th>\u7279\u5fb4<\/th><\/tr><\/thead><tbody><tr><td>\u7b2c1\u4e16\u4ee3<\/td><td>CD3\u03b6\u306e\u307f<\/td><td>\u77ed\u547d\u3001\u5f31\u3044\u5897\u6b96<\/td><\/tr><tr><td>\u7b2c2\u4e16\u4ee3<\/td><td>CD28 <strong>\u307e\u305f\u306f<\/strong> 4-1BB (CD137) + CD3\u03b6<\/td><td>\u4eca\u65e5\u306e\u6a19\u6e96\uff1b\u30ad\u30e0\u30ea\u30a2\uff1d4-1BB\uff1b\u30a4\u30a8\u30b9\u30ab\u30eb\u30bf\uff1dCD28<\/td><\/tr><tr><td>\u7b2c3\u4e16\u4ee3<\/td><td>CD28 <strong>\u305d\u3057\u3066<\/strong> 4-1BB + CD3\u03b6<\/td><td>\u5f37\u3044\u6d3b\u6027\u5316\u3001CRS\u306e\u30ea\u30b9\u30af\u5897\u52a0<\/td><\/tr><tr><td>\u7b2c4\u4e16\u4ee3<\/td><td>\u7b2c2\u907a\u4f1d\u5b50\uff0b\u5c0e\u5165\u907a\u4f1d\u5b50\uff08\u4f8b\uff1aIL-12\u3001IL-15\uff09<\/td><td>\u201e\u300c\u30a2\u30fc\u30de\u30fc\u30c9CAR\u300d\u3001\u816b\u760d\u5fae\u5c0f\u74b0\u5883\u306e\u6539\u5584<\/td><\/tr><tr><td>\u7b2c5\u4e16\u4ee3<\/td><td>\u7b2c2\u907a\u4f1d\u5b50\uff0b\u7d30\u80de\u5185IL-2R\u03b2\u30c9\u30e1\u30a4\u30f3<\/td><td>Jagged-CAR\uff1bJAK-STAT\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>4-1BB\u3068CD28\u5171\u523a\u6fc0\u306e\u6bd4\u8f03<\/strong><br>4-1BB-CAR\uff08Kymriah\uff09\u306f\u9577\u671f\u6301\u7d9a\u6027\u306b\u512a\u308c\u3001\u75b2\u5f0a\u304c\u5c11\u306a\u3044\uff08T\u7d30\u80de\u306e\u75b2\u5f0a\u304c\u5c11\u306a\u3044\uff09\u3002CD28-CAR\uff08Yescarta\uff09\u306f\u521d\u671f\u6d3b\u6027\u5316\u304c\u65e9\u304f\u3001\u65e9\u671f\u594f\u52b9\u7387\u304c\u9ad8\u3044\u304c\u3001\u594f\u52b9\u671f\u9593\u304c\u77ed\u3044\u50be\u5411\u304c\u3042\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u79d1\u5b66\u7684\u6839\u62e0\u304c\u3042\u308b\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5efa\u8a2d\u6982\u8981 CAR\uff1a <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMra1706169\" target=\"_blank\" rel=\"noopener\">June &amp; Sadelain, NEJM 2018<\/a><\/li>\n\n\n\n<li>4-1BB\u3068CD28\u306e\u6bd4\u8f03\uff1a <a href=\"https:\/\/www.nature.com\/articles\/s41591-018-0087-0\" target=\"_blank\" rel=\"noopener\">Salter et al, Nature Medicine 2018<\/a><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Herstellungsprozess_Autolog\"><\/span>\u88fd\u9020\u5de5\u7a0b\uff08\u30aa\u30fc\u30c8\u30ed\u30fc\u30b0\uff09<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30ed\u30a4\u30ab\u30d5\u30a7\u30ec\u30fc\u30b7\u30b9<\/strong><br>3\uff5e5\u6642\u9593\u304b\u3051\u3066\u7d30\u80de\u5206\u96e2\u3092\u884c\u3044\u3001\u60a3\u8005\u306e\u8840\u6db2\u304b\u3089\u5358\u6838\u7403\u3092\u63a1\u53d6\u3059\u308b\u3053\u3068\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>T\u7d30\u80de\u306e\u6d3b\u6027\u5316<\/strong><br>\u6297CD3\/\u6297CD28\u6297\u4f53\u30b3\u30fc\u30c8\u30d3\u30fc\u30ba\u307e\u305f\u306f\u7d44\u63db\u3048\u30ea\u30ac\u30f3\u30c9\u306b\u3088\u308bex vivo\u523a\u6fc0\uff1bIL-2\u304a\u3088\u3073IL-7\/IL-15\u306e\u6dfb\u52a0\u306b\u3088\u308b\u5897\u6b96\u4fc3\u9032\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u907a\u4f1d\u5b50\u5c0e\u5165<\/strong><br>CAR\u907a\u4f1d\u5b50\u306e\u5c0e\u5165<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30ec\u30f3\u30c1\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc<\/strong> (Kymriah\u3001Breyanzi\uff09\uff1a\u5bbf\u4e3b\u30b2\u30ce\u30e0\u3078\u306e\u5b89\u5b9a\u3057\u305f\u7d44\u307f\u8fbc\u307f\uff1b\u9577\u671f\u767a\u73fe<\/li>\n\n\n\n<li><strong>\u30ac\u30f3\u30de\u30ec\u30c8\u30ed\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc<\/strong> (Yescarta\u3001Tecartus\uff09\uff1a\u985e\u4f3c\u3057\u3066\u3044\u308b\u304c\u3001\u633f\u5165\u7a81\u7136\u5909\u7570\u8a98\u767a\u30ea\u30b9\u30af\u306f\u9ad8\u3044<\/li>\n\n\n\n<li><strong>\u30c8\u30e9\u30f3\u30b9\u30dd\u30be\u30f3\u7cfb\uff0fmRNA<\/strong> (\u5b9f\u9a13\u7684\uff09\uff1a\u7d71\u5408\u3057\u306a\u3044\u9078\u629e\u80a2<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u62e1\u5927<\/strong><br>\u5f62\u8cea\u5c0e\u5165\u3055\u308c\u305f\u7d30\u80de\u30927-14\u65e5\u9593\u304b\u3051\u3066\u5897\u6b96\u3055\u305b\u3001\u901a\u5e3810\u2078-10\u2079\u306e\u7d30\u80de\u306b\u3059\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u54c1\u8cea\u7ba1\u7406<\/strong><br>CAR\u5c0e\u5165\u52b9\u7387\u3001\u7121\u83cc\u6027\u3001\u6b8b\u5b58\u6210\u5206\u3001T\u7d30\u80de\u8868\u73fe\u578b\u3001\u52b9\u529b\u8a66\u9a13\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u51b7\u51cd\u4fdd\u5b58\u3068\u8f38\u9001<\/strong><br>\u6cbb\u7642\u30bb\u30f3\u30bf\u30fc\u3078\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30ea\u30f3\u30d1\u9664\u53bb<\/strong><br>\u60a3\u8005\u306fCAR-T\u6ce8\u5165\u306e2-7\u65e5\u524d\u306b\u5316\u5b66\u7642\u6cd5\uff08\u901a\u5e38\u306f\u30d5\u30eb\u30c0\u30e9\u30d3\u30f3\uff0b\u30b7\u30af\u30ed\u30db\u30b9\u30d5\u30a1\u30df\u30c9\uff09\u3092\u53d7\u3051\u3001\u4f53\u5185\u306e\u514d\u75ab\u7d30\u80de\u3092\u6e1b\u5c11\u3055\u305b\u3001\u300c\u7a7a\u9593\u300d\u3092\u4f5c\u308b\uff08\u30ea\u30f3\u30d1\u5265\u96e2\u6027\u6761\u4ef6\u4ed8\u3051\uff09\u3002\u3053\u306e\u30b9\u30c6\u30c3\u30d7\u306b\u3088\u308a\u3001\u6052\u5e38\u7684\u306aIL-7\/IL-15\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u4ecb\u3057\u3066CAR-T\u7d30\u80de\u306e\u5897\u6b96\u3068\u6301\u7d9a\u6027\u304c\u5927\u5e45\u306b\u5897\u52a0\u3059\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30a4\u30f3\u30d5\u30e5\u30fc\u30b8\u30e7\u30f3<\/strong><br>CAR-T\u7d30\u80de\u306e\u5358\u56de\u9759\u8108\u5185\u6ce8\u5165\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u305d\u306e\u80cc\u5f8c\u306b\u3042\u308b\u79d1\u5b66\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30ea\u30f3\u30d1\u6392\u51fa\u30e1\u30ab\u30cb\u30ba\u30e0\uff1a <a href=\"https:\/\/www.nature.com\/articles\/nm1263\" target=\"_blank\" rel=\"noopener\">Gattinoni\u3089\u3001Nature Medicine 2005\u5e74<\/a><\/li>\n\n\n\n<li>\u30d7\u30ed\u30c0\u30af\u30b7\u30e7\u30f3\u306e\u6982\u8981 <a href=\"https:\/\/www.cell.com\/molecular-therapy-family\/molecular-therapy\/fulltext\/S1525-0016(16)45462-1\" target=\"_blank\" rel=\"noopener\">Levine et al, Molecular Therapy 2017<\/a><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wirkmechanismus_Effektorphase\"><\/span>\u4f5c\u7528\u6a5f\u5e8f\u3068\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u76f8<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u6ce8\u5165\u5f8c\u3001CAR-T\u7d30\u80de\u306f\u816b\u760d\u7d30\u80de\u4e0a\u306e\u6a19\u7684\u6297\u539f\u3092\u8a8d\u8b58\u3057\u3001\u514d\u75ab\u5b66\u7684\u30b7\u30ca\u30d7\u30b9\u304c\u5f62\u6210\u3055\u308c\u308b\uff1aCAR\u304c\u6297\u539f\u3068\u7d50\u5408\u2192CD3\u03b6-ITAM\u304c\u30ea\u30f3\u9178\u5316\u2192ZAP-70\/Lck\u30ad\u30ca\u30fc\u30bc\u30ab\u30b9\u30b1\u30fc\u30c9\u2192NF-\u03baB\u3001NFAT\u3001AP-1\u6d3b\u6027\u5316\u2192\u30d1\u30fc\u30d5\u30a9\u30ea\u30f3\/\u30b0\u30e9\u30f3\u30b6\u30a4\u30e0B\u653e\u51fa\uff08\u76f4\u63a5\u7d30\u80de\u6eb6\u89e3\uff09\uff0bIFN-\u03b3\u3001TNF-\u03b1\uff08\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u5206\u6ccc\uff09\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30d1\u30e9\u30ec\u30eb\u3060\uff1a <strong>\u508d\u89b3\u8005\u306e\u6d3b\u6027\u5316<\/strong> - \u653e\u51fa\u3055\u308c\u305f\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306f\u4ed6\u306e\u5185\u56e0\u6027\u514d\u75ab\u7d30\u80de\u3092\u6d3b\u6027\u5316\u3057\u3001\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u653e\u51fa\u75c7\u5019\u7fa4\uff08CRS\uff09\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u79d1\u5b66\u3060\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>CAR-T\u306e\u4f5c\u7528\u6a5f\u5e8f\uff1a <a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.aam8871\" target=\"_blank\" rel=\"noopener\">\u30ea\u30e0\uff06\u30b8\u30e5\u30f3\u3001\u30b5\u30a4\u30a8\u30f3\u30b92017<\/a><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"TCR-T-Zelltherapie_Die_entscheidenden_Unterschiede\"><\/span>TCR-T\u7d30\u80de\u7642\u6cd5\uff1a\u91cd\u8981\u306a\u9055\u3044<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Warum_TCR_und_nicht_CAR_fur_intrazellulare_Antigene\"><\/span>\u306a\u305c\u7d30\u80de\u5185\u6297\u539f\u306b\u306fCAR\u3067\u306f\u306a\u304fTCR\u306a\u306e\u304b\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">CAR\u30ec\u30bb\u30d7\u30bf\u30fc\u304c\u8a8d\u8b58\u3059\u308b\u306e\u306f <strong>\u8868\u9762\u30bf\u30f3\u30d1\u30af\u8cea<\/strong>. .\u3057\u304b\u3057\u3001\u307b\u3068\u3093\u3069\u306e\u816b\u760d\u7279\u7570\u7684\u6297\u539f\u306f\u7d30\u80de\u5185\u306b\u5c40\u5728\u3057\u3066\u3044\u308b\u305f\u3081\uff08\u8ee2\u5199\u56e0\u5b50\u3001\u4ee3\u8b1d\u9175\u7d20\u3001PRAME\u3084MAGE-A4\u306e\u3088\u3046\u306a\u304c\u3093\u7cbe\u5de3\u6297\u539f\uff09\u3001CAR-T\u306f\u3053\u308c\u3089\u306e\u6a19\u7684\u3092\u8a8d\u8b58\u3067\u304d\u306a\u3044\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5929\u7136\u306eTCR\u306b\u306f\u7d30\u80de\u5185\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u8a8d\u8b58\u3059\u308b\u80fd\u529b\u304c\u3042\u308b\u3002 <strong>\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0<\/strong> \u306f\u30018-11\u30a2\u30df\u30ce\u9178\u9577\u306e\u30da\u30d7\u30c1\u30c9\u306b\u5206\u89e3\u3055\u308c\u308b\u3002\u3053\u308c\u3089\u306e\u30da\u30d7\u30c1\u30c9\u306f\u5c0f\u80de\u4f53\u3067\u5206\u89e3\u3055\u308c\u3001\u6b21\u306e\u3088\u3046\u306b\u306a\u308b\u3002 <strong>MHC\u30af\u30e9\u30b9I\u5206\u5b50\uff08\u30d2\u30c8\u3067\u306fHLA\uff09<\/strong> \u306b\u7d50\u5408\u3057\u3001\u7d30\u80de\u8868\u9762\u306b\u8f38\u9001\u3055\u308c\u308b\u3002\u305d\u3053\u3067\u03b1\u03b2-TCR\u306b\u3088\u3063\u3066\u7d50\u5408\u3055\u308c\u308b\u304c\u3001\u3053\u306e\u6a5f\u69cb\u306f\u3059\u3079\u3066\u306e\u6709\u6838\u4f53\u7d30\u80de\u3067\u6709\u52b9\u3067\u3042\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>TCR\u6cbb\u7642\u306e\u6280\u8853\u7684\u8ab2\u984c<\/strong> \u5929\u7136\u306e\u9ad8\u89aa\u548c\u6027TCR\u306f\u3001\u7279\u5b9a\u306eHLA\u5bfe\u7acb\u907a\u4f1d\u5b50\uff08\u4f8b\u3048\u3070HLA-A*02:01\u3001\u767d\u4eba\u96c6\u56e3\u306e\u7d0440-50\u306e%\u306b\u5b58\u5728\u3059\u308b\uff09\u306e\u6587\u8108\u3067\u306e\u307f\u7279\u5b9a\u306e\u30da\u30d7\u30c1\u30c9\u3092\u8a8d\u8b58\u3059\u308b\u3002\u3064\u307e\u308a\u3001\u60a3\u8005\u306fHLA\u306b\u9069\u5408\u3057\u3001\u304b\u3064\u6a19\u7684\u6297\u539f\u306b\u5bfe\u3057\u3066\u816b\u760d\u967d\u6027\u3067\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3002.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Struktur_des_therapeutischen_TCR\"><\/span>\u6cbb\u7642\u7528TCR\u306e\u69cb\u9020<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u6cbb\u7642\u7528TCR\u306f\u3001\u305d\u306e\u307b\u3068\u3093\u3069\u304c <strong>\u03b1\u03b2-TCR\u30d8\u30c6\u30ed\u30c0\u30a4\u30de\u30fc<\/strong>, \u3069\u306e\u3088\u3046\u306a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30d5\u30a1\u30fc\u30b8\u30c7\u30a3\u30b9\u30d7\u30ec\u30a4\u307e\u305f\u306f\u30de\u30a6\u30b9\u306b\u3088\u308b\u30d2\u30c8\u5316\u306b\u3088\u3063\u3066\u958b\u767a\u3055\u308c\u3001\u89aa\u548c\u6027\u304c\u6975\u3081\u3066\u9ad8\u3044\uff08KD\u304cpM\u306e\u7bc4\u56f2\uff09\u3002\u5929\u7136\u306eTCR\u306f\u4e2d\u7a0b\u5ea6\u306e\u89aa\u548c\u6027\uff08\u03bcM\uff09\u3057\u304b\u306a\u3044\u3002\u89aa\u548c\u6027\u304c\u9ad8\u3059\u304e\u308b\u3068\u81ea\u5df1\u514d\u75ab\u306b\u3064\u306a\u304c\u308b\u304b\u3089\u3067\u3042\u308b\u3002<\/li>\n\n\n\n<li>\u30de\u30a6\u30b9\u7f6e\u63db\u3084\u30b8\u30b9\u30eb\u30d5\u30a3\u30c9\u7d50\u5408\u306b\u3088\u308a\u3001\u5185\u56e0\u6027TCR\u9396\u3068\u306e\u610f\u56f3\u3057\u306a\u3044\u30da\u30a2\u30ea\u30f3\u30b0\u304b\u3089\u5b89\u5b9a\u5316\u3055\u308c\u308b<\/li>\n\n\n\n<li>\u30ec\u30f3\u30c1\u30a6\u30a4\u30eb\u30b9\u5c0e\u5165\u306b\u3088\u3063\u3066\u60a3\u8005\u81ea\u8eab\u306eT\u7d30\u80de\u306b\u5c0e\u5165\u3055\u308c\u308b\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u79d1\u5b66\u3060\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>TCR\u89aa\u548c\u6027\u5de5\u5b66\uff1a <a href=\"https:\/\/www.jimmunol.org\/content\/180\/9\/6116\" target=\"_blank\" rel=\"noopener\">Robbins\u3089\u3001Journal of Immunology\u8a8c2008\u5e74<\/a><\/li>\n\n\n\n<li>\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u6982\u8981 TCR-T\uff1a <a href=\"https:\/\/aacrjournals.org\/cancerimmunolres\/article\/7\/8\/1236\/469286\" target=\"_blank\" rel=\"noopener\">Dangaj et al, Cancer Immunology Research 2019<\/a><\/li>\n\n\n\n<li>\u30c6\u30bb\u30e9\u7528MAGE-A4 TCR\u30d9\u30fc\u30b9\uff1a <a href=\"https:\/\/aacrjournals.org\/clincancerres\/article\/25\/24\/7537\/82286\" target=\"_blank\" rel=\"noopener\">Kageyama et al, Clin Cancer Research 2019<\/a><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"TIL-Therapie_%E2%80%93_Prinzip_der_naturlichen_Tumorerkennung\"><\/span>TIL\u7642\u6cd5-\u81ea\u7136\u816b\u760d\u691c\u51fa\u306e\u539f\u7406<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Biologische_Grundlage\"><\/span>\u751f\u7269\u5b66\u7684\u57fa\u790e<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u816b\u760d\u306b\u306f\u514d\u75ab\u7d30\u80de\u304c\u6d78\u6f64\u3057\u3066\u3044\u308b\u3002 <strong>\u816b\u760d\u6d78\u6f64\u30ea\u30f3\u30d1\u7403\uff08TIL\uff09<\/strong>. .\u3053\u308c\u3089\u306eT\u7d30\u80de\u306f\u3059\u3067\u306b\u816b\u760d\u3092\u8a8d\u8b58\u3057\u3066\u3044\u308b\u304c\u3001\u514d\u75ab\u6291\u5236\u6027\u306e\u816b\u760d\u5fae\u5c0f\u74b0\u5883\uff08TME\uff09\u306e\u305f\u3081\u306b\u3001\u3057\u3070\u3057\u3070\u75b2\u5f0a\u3057\u3066\u3044\u305f\u308a\u3001\u30a2\u30cd\u30eb\u30ae\u30fc\u72b6\u614b\u3067\u3042\u3063\u305f\u308a\u3001\u6570\u304c\u5c11\u306a\u3059\u304e\u305f\u308a\u3059\u308b\u3002\u816b\u760d\u5185\u306eTIL\u5bc6\u5ea6\u304c\u9ad8\u3044\u307b\u3069\u3001\u591a\u304f\u306e\u7a2e\u985e\u306e\u764c\u306b\u304a\u3044\u3066\u4e88\u5f8c\u304c\u826f\u597d\u3067\u3042\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">TIL\u7642\u6cd5\uff081980\u5e74\u4ee3\u306b\u30d9\u30bb\u30b9\u30c0\u306eNCI\u3067\u30b9\u30c6\u30a3\u30fc\u30d6\u30f3\u30fb\u30ed\u30fc\u30bc\u30f3\u30d0\u30fc\u30b0\u304c\u958b\u767a\uff09\u3068\u3044\u3046\u8003\u3048\u65b9\u304c\u3042\u308b\uff1a\u3059\u3067\u306b\u816b\u760d\u7279\u7570\u7684\u306aT\u7d30\u80de\u3092\u514d\u75ab\u6291\u5236\u74b0\u5883\u304b\u3089\u89e3\u653e\u3057\u3001\u751f\u4f53\u5916\u3067\u5927\u91cf\u306b\u6d3b\u6027\u5316\u30fb\u5897\u6b96\u3055\u305b\u3001\u75b2\u5f0a\u3059\u308b\u50be\u5411\u304c\u3042\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u6cbb\u7642\u52b9\u679c\u304c\u5f97\u3089\u308c\u308b\u3088\u3046\u306b\u5927\u91cf\u306b\u623b\u3059\u3002.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Herstellungsprozess_Lifileucel\"><\/span>\u88fd\u9020\u5de5\u7a0b\uff08\u30ea\u30d5\u30a3\u30ea\u30e5\u30fc\u30bb\u30eb\uff09<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u816b\u760d\u5207\u9664<\/strong><br>\u5c11\u306a\u304f\u3068\u30821.5cm\u00b3\u306e\u816b\u760d\u7d44\u7e54\u3092\u5916\u79d1\u624b\u8853\u3067\u6458\u51fa\u3057\u3001\u76f4\u3061\u306b\u691c\u67fb\u306b\u304b\u3051\u308b\u3002 <a href=\"https:\/\/www.iovance.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u30a2\u30a4\u30aa\u30d0\u30f3\u30b9\u30fb\u30d0\u30a4\u30aa\u30bb\u30e9\u30d4\u30e5\u30fc\u30c6\u30a3\u30af\u30b9\u793e.<\/a> \u3092\u9001\u3063\u305f\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u521d\u671f\u5c55\u958b\uff08\u7d0411\u65e5\u9593\uff09<\/strong><br>\u816b\u760d\u306f\u6a5f\u68b0\u7684\u30fb\u9175\u7d20\u7684\u306b\u89e3\u96e2\u3055\u305b\u308b\u3002TIL\u306fIL-2\u5b58\u5728\u4e0b\u3067\u57f9\u990a\u2192Pre-REP\uff08Pre-Rapid Expansion Protocol\uff09\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6025\u62e1\u5927\uff08\u7d0411\u65e5\u9593\uff09<\/strong><br>TIL\u306f\u3001\u6297CD3\u6297\u4f53\uff08OKT3\uff09\u3001\u7167\u5c04\u3055\u308c\u305f\u540c\u7a2ePBMC\uff08\u6297\u539f\u63d0\u793a\u7d30\u80de\u3068\u3057\u3066\u50cd\u304f\uff09\u304a\u3088\u3073IL-2\u3067\u51e6\u7406\u3055\u308c\u308b\u3002 <strong>&gt;7.5 \u00d7 10\u2079\u7d30\u80de<\/strong> \u304c\u62e1\u5927\u3059\u308b\uff08\u6570\u767e\u4e07\u4eba\u304b\u3089\u6570\u5341\u5104\u4eba\u3078\uff09\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30ea\u30f3\u30d1\u30c9\u30ec\u30ca\u30fc\u30b8\u3068\u6ce8\u5165<\/strong><br>CAR-T\u3068\u540c\u3058\uff1aFlu\/Cy\u306b\u3088\u308b\u30b3\u30f3\u30c7\u30a3\u30b7\u30e7\u30cb\u30f3\u30b0\u306e\u5f8c\u3001TIL\u3092\u5358\u56de\u6ce8\u5165\u3057\u3001\u3055\u3089\u306bIL-2\u3092\u6295\u4e0e\u3057\u3066in vivo\u3067\u62e1\u5927\u3059\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u671f\u9593<\/strong><br>\u816b\u760d\u6458\u51fa\u304b\u3089\u6ce8\u5165\u307e\u3067\u7d046\uff5e7\u9031\u9593\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u79d1\u5b66\u3060\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u30ed\u30fc\u30bc\u30f3\u30d0\u30fc\u30b0\u306e\u5148\u99c6\u7684\u306a\u4ed5\u4e8b\u3067\u3042\u308b\uff1a <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJM198812223192529\" target=\"_blank\" rel=\"noopener\">\u30ed\u30fc\u30bc\u30f3\u30d0\u30fc\u30b0\u3089\u3001NEJM 1988\u5e74<\/a><\/li>\n\n\n\n<li>Lifileucel\u30d5\u30a7\u30fc\u30ba2\u30d4\u30dc\u30bf\u30eb\u8a66\u9a13\uff08C-144-01\uff09\uff1a <a href=\"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.21.02179\" target=\"_blank\" rel=\"noopener\">\u30c1\u30a7\u30ba\u30cb\u30fc\u3089\u3001JCO 2022\u5e74<\/a><\/li>\n\n\n\n<li>5\u5e74\u9593\u306e\u8ffd\u8de1\u8abf\u67fb\uff1a <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40699950\/\" target=\"_blank\" rel=\"noopener\">PubMed FDA\u627f\u8a8d\u6982\u8981 2024\u5e74<\/a><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Herausforderungen_%E2%80%93_aktuelle_Forschungsansatze\"><\/span>\u8ab2\u984c - \u73fe\u5728\u306e\u7814\u7a76\u30a2\u30d7\u30ed\u30fc\u30c1<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Antigen-Escape\"><\/span>\u6297\u539f\u30a8\u30b9\u30b1\u30fc\u30d7<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u554f\u984c\u306e\u5b9a\u7fa9<\/strong><br>\u816b\u760d\u7d30\u80de\u306f\u6a19\u7684\u6297\u539f\u306e\u767a\u73fe\u3092\u4f4e\u4e0b\u3055\u305b\u305f\u308a\u3001\u6d88\u5931\u3055\u305b\u305f\u308a\u3059\u308b\u3002CD19-CAR-T\u3067\u306f\u3001CD19\u9670\u6027\u306e\u518d\u767a\u304c30-40 %\u4f8b\u3067\u8d77\u3053\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30bd\u30ea\u30e5\u30fc\u30b7\u30e7\u30f3<\/strong><br>\u30c7\u30e5\u30a2\u30eb\u30bf\u30fc\u30b2\u30c6\u30a3\u30f3\u30b0\u6226\u7565\uff08CD19+CD22\u3001BCMA+CD38\uff09\u3001\u30bf\u30f3\u30c7\u30e0CAR\u3001\u30ed\u30b8\u30c3\u30af\u30b2\u30fc\u30c8CAR\uff08AND\u30b2\u30fc\u30c8\uff1a2\u3064\u306e\u6297\u539f\u304c\u5fc5\u8981\u3001NOT\u30b2\u30fc\u30c8\uff1a\u9632\u5fa1\u6297\u539f\u306e\u306a\u3044\u7d30\u80de\u306e\u307f\u3092\u6bba\u3059\uff09\u3002.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.nature.com\/articles\/nm.4164\" target=\"_blank\" rel=\"noopener\">Ruella et al, Nature Medicine 2016 (CD19-Escape)<\/a><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"T-Zell-Erschopfung_Exhaustion\"><\/span>T\u7d30\u80de\u6d88\u8017\uff08\u75b2\u5f0a\uff09<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u554f\u984c\u306e\u5b9a\u7fa9<\/strong><br>\u816b\u760d\u7d30\u80de\u306f\u6a19\u7684\u6297\u539f\u306e\u767a\u73fe\u3092\u4f4e\u4e0b\u3055\u305b\u305f\u308a\u3001\u6d88\u5931\u3055\u305b\u305f\u308a\u3059\u308b\u3002CD19-CAR-T\u3067\u306f\u3001CD19\u9670\u6027\u306e\u518d\u767a\u304c30-40 %\u4f8b\u3067\u8d77\u3053\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6162\u6027\u7684\u306a\u6297\u539f\u66dd\u9732\u2192\u75b2\u5f0a\u30de\u30fc\u30ab\u30fc\u306e\u767a\u73fe\uff08PD-1\u3001TIM-3\u3001LAG-3\u3001TOX\u8ee2\u5199\u56e0\u5b50\uff09\u2192\u6a5f\u80fd\u55aa\u5931\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u89e3\u6c7a\u7b56<\/strong> \u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\u3068\u306e\u4f75\u7528\u3001TET2\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u306b\u3088\u308b\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u30fb\u30ea\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\u3001\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u3092\u7d44\u307f\u8fbc\u3093\u3060\u6b21\u4e16\u4ee3CAR\u30c7\u30b6\u30a4\u30f3\u3002.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41586-019-1546-z\" target=\"_blank\" rel=\"noopener\">Chen et al, Nature 2019\uff08TET2\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\uff09<\/a><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Tumormikroumgebung_TME\"><\/span>\u816b\u760d\u5fae\u5c0f\u74b0\u5883\uff08TME\uff09<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u554f\u984c\u306e\u5b9a\u7fa9<\/strong><br>\u816b\u760d\u7d30\u80de\u306f\u6a19\u7684\u6297\u539f\u306e\u767a\u73fe\u3092\u4f4e\u4e0b\u3055\u305b\u305f\u308a\u3001\u6d88\u5931\u3055\u305b\u305f\u308a\u3059\u308b\u3002CD19-CAR-T\u3067\u306f\u3001CD19\u9670\u6027\u306e\u518d\u767a\u304c30-40 %\u4f8b\u3067\u8d77\u3053\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u56fa\u5f62\u816b\u760d\u306f\u3001\u4f4e\u9178\u7d20\u3001\u30d6\u30c9\u30a6\u7cd6\u6b20\u4e4f\u3001\u514d\u75ab\u6291\u5236\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08TGF-\u03b2\u3001IL-10\uff09\u3001Treg\u3001MDSCs\u3068\u3044\u3063\u305f\u6575\u5bfe\u7684\u306a\u5fae\u5c0f\u74b0\u5883\u3092\u6301\u3064\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30bd\u30ea\u30e5\u30fc\u30b7\u30e7\u30f3<\/strong><br>IL-12\/IL-15\/IL-18\u3092\u5206\u6ccc\u3059\u308b\u88c5\u7532CAR\u3001PD-1\u8010\u6027CAR\u3001\u6297VEGF\u3068\u306e\u4f75\u7528\u3001\u816b\u760d\u5185\u5c40\u6240\u6ce8\u5c04\u3002.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41598-017-10259-0\" target=\"_blank\" rel=\"noopener\">Yeku et al, Scientific Reports 2017\uff08\u88c5\u7532CAR\uff09<\/a><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Zytokinsturm_CRS_ICANS\"><\/span>\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30b9\u30c8\u30fc\u30e0\uff08CRS\uff09\u3068ICANS<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u554f\u984c\u306e\u5b9a\u7fa9<\/strong><br>CRS\u306f\u3001\u6d3b\u6027\u5316\u3057\u305fCAR-T\u3068\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u3088\u308b\u5927\u91cf\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u653e\u51fa\uff08IL-6\u3001IFN-\u03b3\u3001IL-1\u03b2\uff09\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u3002\u91cd\u75c7\u306eCRS\uff08\u30b0\u30ec\u30fc\u30c93-4\uff09\u306b\u306f\u96c6\u4e2d\u6cbb\u7642\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002ICANS\uff08\u795e\u7d4c\u6bd2\u6027\uff09\u306f\u5185\u76ae\u6d3b\u6027\u5316\u3068\u8840\u6db2\u8133\u95a2\u9580\u6a5f\u80fd\u969c\u5bb3\u306b\u8d77\u56e0\u3059\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30de\u30cd\u30b8\u30e1\u30f3\u30c8<\/strong><br>\u30c8\u30b7\u30ea\u30ba\u30de\u30d6\uff08IL-6R\u906e\u65ad\u85ac\uff09\u3001\u30b3\u30eb\u30c1\u30b3\u30b9\u30c6\u30ed\u30a4\u30c9\u3001\u30a2\u30ca\u30ad\u30f3\u30e9\uff08IL-1\u906e\u65ad\u85ac\uff09\uff1b\u65e9\u671f\u4ecb\u5165\u306b\u3088\u308a\u6210\u7e3e\u304c\u6539\u5584\u3059\u308b\u3002.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4116524\/\" target=\"_blank\" rel=\"noopener\">Lee et al, Blood 2014 - CRS\u30b0\u30ec\u30fc\u30c7\u30a3\u30f3\u30b0\u30b7\u30b9\u30c6\u30e0<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.nature.com\/articles\/nrneurol.2018.138\" target=\"_blank\" rel=\"noopener\">Neelapu et al, Nature Reviews Neurology 2018 - ICANS<\/a><\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Allogene_%E2%80%9EOff-the-shelf%E2%80%9C-Therapien\"><\/span>\u540c\u7a2e\u300c\u65e2\u88fd\u300d\u7642\u6cd5<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u554f\u984c\u306e\u5b9a\u7fa9<\/strong><br>\u816b\u760d\u7d30\u80de\u306f\u6a19\u7684\u6297\u539f\u306e\u767a\u73fe\u3092\u4f4e\u4e0b\u3055\u305b\u305f\u308a\u3001\u6d88\u5931\u3055\u305b\u305f\u308a\u3059\u308b\u3002CD19-CAR-T\u3067\u306f\u3001CD19\u9670\u6027\u306e\u518d\u767a\u304c30-40 %\u4f8b\u3067\u8d77\u3053\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u81ea\u5bb6\u751f\u7523\u306b\u306f3\uff5e6\u9031\u9593\u304b\u304b\u308a\u3001\u8cbb\u7528\u3082\u9ad8\u3044\uff0840\u4e07\uff5e60\u4e07\u30e6\u30fc\u30ed\uff09\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30bd\u30ea\u30e5\u30fc\u30b7\u30e7\u30f3<\/strong><br>\u5185\u56e0\u6027TCR\u306eCRISPR\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\uff08GvHD\u4e88\u9632\uff09\u304a\u3088\u3073HLA\u6210\u5206\u306eCRISPR\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\uff08\u62d2\u7d76\u53cd\u5fdc\u4e88\u9632\uff09\u3092\u4f34\u3046\u3001\u5065\u5eb7\u306a\u30c9\u30ca\u30fc\u304b\u3089\u306e\u540c\u7a2eCAR-T\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u73fe\u5728\u306e\u30c7\u30fc\u30bf<\/strong><br>CTX112\uff08CRISPR-\u540c\u7a2eCD19-CAR-T\uff09\u304c\u7b2c1\u76f8\u8a66\u9a13\u3067CLL\u306b\u521d\u306e\u5b8c\u5168\u5bdb\u89e3\u3092\u793a\u3059\u3002.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.abb4845\" target=\"_blank\" rel=\"noopener\">Stadtmauer et al, Science 2020 - CRISPR CAR-T Phase 1<\/a><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"27_Quantitative_Wirksamkeitsdaten_im_Uberblick\"><\/span>2.7 \u5b9a\u91cf\u7684\u6709\u52b9\u6027\u30c7\u30fc\u30bf\u4e00\u89a7<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u30bb\u30e9\u30d4\u30fc<\/th><th>\u8868\u793a<\/th><th>ORR<\/th><th>CR\u30ec\u30fc\u30c8<\/th><th>OS\u4e2d\u592e\u5024<\/th><th>\u30bd\u30fc\u30b9<\/th><\/tr><\/thead><tbody><tr><td>\u30c6\u30a3\u30b5\u30b2\u30f3\u30ec\u30ad\u30e5\u30bb\u30eb<\/td><td>\u5c0f\u5150B-ALL<\/td><td>81 %<\/td><td>60 %<\/td><td>NR\uff0812\u30f5\u6708\u6642\u70b9\u306763 %\uff09<\/td><td>NEJM 2018<\/td><\/tr><tr><td>\u30a2\u30af\u30b7\u30ab\u30d6\u30bf\u30b8\u30a7\u30f3\u30bb\u30eb<\/td><td>DLBCL 3\u6b21\u6cbb\u7642<\/td><td>83 %<\/td><td>58 %<\/td><td>NR\uff0812\u30f5\u6708\u306774 %\uff09<\/td><td>NEJM 2017<\/td><\/tr><tr><td>\u30c1\u30eb\u30bf\u30ab\u30d6\u30bf\u30b8\u30a7\u30f3\u30bb\u30eb<\/td><td>\u30de\u30eb\u30c1\u9aa8\u9ac4\u816b<\/td><td>98 %<\/td><td>78 %<\/td><td>NR\uff0812\u30f5\u6708\u6642\u70b9\u306780 %\u4ee5\u4e0a\uff09<\/td><td>\u30e9\u30f3\u30bb\u30c3\u30c82021<\/td><\/tr><tr><td>\u30ea\u30d5\u30a3\u30ea\u30e5\u30fc\u30bb\u30eb<\/td><td>\u30e1\u30e9\u30ce\u30fc\u30de<\/td><td>31,4 %<\/td><td>7,5 %<\/td><td>NR\uff0824\u30f5\u6708\u6642\u70b9\u3067% 49\u4f8b\uff09<\/td><td>JCO 2022<\/td><\/tr><tr><td>\u30a2\u30d5\u30a1\u30df\u30c8\u30ec\u30b9\u30b2\u30f3\u30bb\u30eb<\/td><td>\u6ed1\u819c\u8089\u816b<\/td><td>43 %<\/td><td>4 %<\/td><td>16.4\u30ab\u6708<\/td><td>\u30e9\u30f3\u30bb\u30c3\u30c82024<\/td><\/tr><tr><td>\u30c6\u30d9\u30f3\u30bf\u30d5\u30b9\u30d7<\/td><td>\u3076\u3069\u3046\u819c\u9ed2\u8272\u816b<\/td><td>9 % (ORR)<\/td><td>&lt;1 %<\/td><td>21.7\u30ab\u6708<\/td><td>NEJM 2021<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><em>(NR\u306f\u672a\u5230\u9054\u3001OS*\u306f\u672a\u5230\u9054\uff09\u3002<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">*<em>OS<\/em> (<em>\u5168\u751f\u5b58\u671f\u9593<\/em>\u00a0) - \u4f8b\uff1a \u201e<em>OS\u4e2d\u592e\u5024 21.7<\/em>\u201e\u300c\u60a3\u8005\u306e\u534a\u6570\u306f21.7\u30f5\u6708\u5f8c\u306b\u6b7b\u4ea1\u3057\u3001\u6b8b\u308a\u306e\u534a\u6570\u306f\u307e\u3060\u751f\u5b58\u3057\u3066\u3044\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Weiterfuhrende_Literatur_Ressourcen\"><\/span>\u305d\u306e\u4ed6\u306e\u8cc7\u6599<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30ec\u30d3\u30e5\u30fc<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.aar6711\" target=\"_blank\" rel=\"noopener\">June et al, Science 2018 - CAR-T\u7642\u6cd5\u306e\u6982\u8981<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00428-019-02571-3\" target=\"_blank\" rel=\"noopener\">Rohaan et al, Virchows Arch 2019 - TIL\u7642\u6cd5\u306e\u30ec\u30d3\u30e5\u30fc<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41586-019-1840-9\" target=\"_blank\" rel=\"noopener\">Stadtmauer\u3089\u3001Nature\u8a8c2020\u5e74-\u540c\u7a2eTCR\/CAR-T<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3068\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/clinicaltrials.gov\/search?term=CAR-T+OR+TIL+OR+TCR-T&amp;recency=5\" target=\"_blank\" rel=\"noopener\">ClinicalTrials.gov - \u9032\u884c\u4e2d\u306e\u3059\u3079\u3066\u306e\u514d\u75ab\u7d30\u80de\u7642\u6cd5\u81e8\u5e8a\u8a66\u9a13<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.cancer.gov\/about-cancer\/treatment\/types\/immunotherapy\/t-cell-transfer-therapy\" target=\"_blank\" rel=\"noopener\">NCI - \u514d\u75ab\u7642\u6cd5\u306e\u6982\u8981<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.dgho.de\/informationen\/stellungnahmen\/gute-wissenschaftliche-praxis\/car-t-zellen\" target=\"_blank\" rel=\"noopener\">\u30c9\u30a4\u30c4\u8840\u6db2\u5b66\u4f1a\uff08DGHO\uff09 - CAR-T\u7642\u6cd5<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u60a3\u8005\u306b\u3084\u3055\u3057\u3044\u30ea\u30bd\u30fc\u30b9\uff08\u30c9\u30a4\u30c4\u8a9e\uff09\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.krebshilfe.de\/informieren\/ueber-krebs\/therapie\/immuntherapie\/\" target=\"_blank\" rel=\"noopener\">Krebshilfe Deutschland - \u514d\u75ab\u7642\u6cd5\u306e\u8aac\u660e<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.kitz-heidelberg.de\/forschungsprogramme\/zell-und-gentherapie\/\" target=\"_blank\" rel=\"noopener\">KiTZ \u30cf\u30a4\u30c7\u30eb\u30d9\u30eb\u30af - \u60a3\u8005\u3068\u514d\u75ab\u7642\u6cd5<\/a><\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\"><em>\u308f\u305a\u304b10\u5e74\u8db3\u3089\u305a\u306e\u9593\u306b\u3001\u514d\u75ab\u7d30\u80de\u7642\u6cd5\u306f\u5b9f\u9a13\u7684\u306a\u6982\u5ff5\u304b\u3089\u6a19\u6e96\u7684\u306a\u81e8\u5e8a\u7642\u6cd5\u3078\u3068\u98db\u8e8d\u3092\u9042\u3052\u3001\u627f\u8a8d\u3055\u308c\u305f\u88fd\u54c1\u3068\u9069\u5fdc\u75c7\u306e\u6570\u306f\u6025\u901f\u306b\u5897\u3048\u7d9a\u3051\u3066\u3044\u308b\u3002\u9069\u5fdc\u3068\u306a\u308b\u60a3\u8005\u306b\u3068\u3063\u3066\u3001\u514d\u75ab\u7d30\u80de\u7642\u6cd5\u306f\u6cbb\u7652\u306e\u53ef\u80fd\u6027\u306e\u3042\u308b\u552f\u4e00\u306e\u9078\u629e\u80a2\u3068\u306a\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3002.<\/em><\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Weltweit_zugelassene_Immunzelltherapien\"><\/span>\u4e16\u754c\u7684\u306b\u627f\u8a8d\u3055\u308c\u305f\u514d\u75ab\u7d30\u80de\u7642\u6cd5<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u30b9\u30c6\u30fc\u30bf\u30b9 02.2026<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Einleitung_Die_drei_grosen_Klassen\"><\/span>\u306f\u3058\u3081\u306b\uff1a3\u3064\u306e\u4e3b\u8981\u30af\u30e9\u30b9<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u65e5\u3001\u300c\u514d\u75ab\u7d30\u80de\u7642\u6cd5\u300d\u3068\u3044\u3046\u7528\u8a9e\u306f\u3001\u304c\u3093\u9818\u57df\u306b\u304a\u3044\u30663\u3064\u306e\u7570\u306a\u308b\u88fd\u54c1\u30ab\u30c6\u30b4\u30ea\u30fc\u3092\u30ab\u30d0\u30fc\u3057\u3066\u3044\u308b\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1.CAR-T\u7d30\u80de\u7642\u6cd5<\/strong> (\u30ad\u30e1\u30e9\u6297\u539f\u53d7\u5bb9\u4f53T\u7d30\u80de\uff09<br>\u7d30\u80de\u8868\u9762\u306e\u816b\u760d\u6297\u539f\u3092\u8a8d\u8b58\u3059\u308b\u5408\u6210\u8868\u9762\u30ec\u30bb\u30d7\u30bf\u30fc\u3092\u6301\u3064\u907a\u4f1d\u5b50\u6539\u5909T\u7d30\u80de\u3002\u73fe\u5728\u307e\u3067\u306b\u627f\u8a8d\u3055\u308c\u3066\u3044\u308b\u88fd\u54c1\u306f\u3059\u3079\u3066CD19\u307e\u305f\u306fBCMA\u306b\u5bfe\u3059\u308b\u3082\u306e\u3067\u3001\u8840\u6db2\u304c\u3093\u306b\u5bfe\u3057\u3066\u8a8d\u53ef\u3055\u308c\u3066\u3044\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>2.TCR-T\u7d30\u80de\u7642\u6cd5<\/strong> (T\u7d30\u80de\u53d7\u5bb9\u4f53T\u7d30\u80de)<br>HLA\u8907\u5408\u4f53\u4e0a\u306b\u63d0\u793a\u3055\u308c\u305f\u7d30\u80de\u5185\u816b\u760d\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u8a8d\u8b58\u3059\u308b\u6700\u9069\u5316\u3055\u308c\u305f\u5929\u7136T\u7d30\u80de\u30ec\u30bb\u30d7\u30bf\u30fc\u3092\u6301\u3064\u907a\u4f1d\u5b50\u7d44\u307f\u63db\u3048T\u7d30\u80de\u30022024\u5e74\u306b\u56fa\u5f62\u304c\u3093\u306b\u5bfe\u3057\u3066\u521d\u3081\u3066\u627f\u8a8d\u3055\u308c\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7b2c3\u56deTIL\u7642\u6cd5<\/strong> (\u816b\u760d\u6d78\u6f64\u30ea\u30f3\u30d1\u7403\uff09<br>\u60a3\u8005\u306e\u816b\u760d\u304b\u3089\u63a1\u53d6\u3057\u305f\u975e\u907a\u4f1d\u5b50\u7d44\u63db\u3048T\u7d30\u80de\u3092\u5927\u91cf\u5897\u6b96\u3055\u305b\u3001\u518d\u6ce8\u5165\u3059\u308b\u30022024\u5e74\u306b\u30e1\u30e9\u30ce\u30fc\u30de\u306b\u5bfe\u3057\u3066\u521d\u3081\u3066\u627f\u8a8d\u3055\u308c\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2024\u5e7412\u6708\u73fe\u5728\u3001FDA\u306f6\u3064\u306eCAR-T\u7d30\u80de\u7642\u6cd5\u3092\u627f\u8a8d\u3057\u3066\u304a\u308a\u3001\u4e16\u754c\u4e2d\u306710\u306eCAR-T\u7d30\u80de\u7642\u6cd5\u304c\u5e02\u8ca9\u3055\u308c\u3066\u3044\u308b\u3002\u3055\u3089\u306b\u3001TIL\u7642\u6cd5\uff08Lifileucel\uff09\u3068TCR\u7642\u6cd5\uff08Afamitresgene autoleucel\uff09\u304c\u3042\u308b\u3002. <a href=\"https:\/\/www.curemelanoma.org\/blog\/melanoma-clinical-trials-to-watch-fall-2025\" target=\"_blank\" rel=\"noreferrer noopener\">\u9053\u5fb3\u518d\u6b66\u88c5<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"CAR-T-ZELLTHERAPIEN\"><\/span>\u30ab\u30fcT\u7d30\u80de\u7642\u6cd5<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Tisagenlecleucel_Kymriah%C2%AE_%E2%80%93_Novartis\"><\/span>\u30c1\u30b5\u30b2\u30f3\u30ec\u30af\u30ed\u30a4\u30bb\u30eb\uff08Kymriah\u00ae\uff09 - \uff08\u82f1\u8a9e <em>\u30ce\u30d0\u30eb\u30c6\u30a3\u30b9<\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6a19\u7684\u6297\u539f\uff1a<\/strong> CD19 <br><strong>\u516c\u8a8d\uff1a<\/strong> FDA 2017 \/ EMA 2018<br><strong>\u4e16\u754c\u3067\u521d\u3081\u3066\u8a8d\u53ef\u3055\u308c\u305fCAR-T\u88fd\u54c1<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u9069\u5fdc\u75c7<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>25\u6b73\u307e\u3067\u306e\u5c0f\u5150\u304a\u3088\u3073\u82e5\u5e74\u6210\u4eba\uff1a\u518d\u767a\/\u96e3\u6cbb\u6027\u306eB\u7d30\u80de\u6027ALL\uff08\u6025\u6027\u30ea\u30f3\u30d1\u82bd\u7403\u6027\u767d\u8840\u75c5\uff09<\/li>\n\n\n\n<li>\u6210\u4eba\uff1a2\u7a2e\u985e\u4ee5\u4e0a\u306e\u5168\u8eab\u7642\u6cd5\u5f8c\u306e\u518d\u767a\/\u96e3\u6cbb\u6027\u5927\u7d30\u80de\u578bB\u7d30\u80de\u30ea\u30f3\u30d1\u816b\uff08LBCL\uff09<\/li>\n\n\n\n<li>\u518d\u767a\/\u96e3\u6cbb\u6027\u306e\u6ffe\u80de\u6027\u30ea\u30f3\u30d1\u816b\uff08FL\uff09<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6700\u3082\u91cd\u8981\u306a\u7814\u7a76<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>ELIANA\u8a66\u9a13\uff08\u5168\u5c0f\u5150\uff09\uff1a <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT02435849\" target=\"_blank\" rel=\"noopener\">NCT02435849<\/a> | <a href=\"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.21.01019\" target=\"_blank\" rel=\"noopener\">JCO 2021<\/a><\/li>\n\n\n\n<li>JULIET\u8a66\u9a13\uff08LBCL\uff09\uff1a <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT02445248\" target=\"_blank\" rel=\"noopener\">NCT02445248<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u8a8d\u53ef\u5f53\u5c40<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u98df\u54c1\u533b\u85ac\u54c1\u5c40<\/li>\n\n\n\n<li>EMA<\/li>\n\n\n\n<li>TGA\uff08\u30aa\u30fc\u30b9\u30c8\u30e9\u30ea\u30a2\uff09<\/li>\n\n\n\n<li>PMDA\uff08\u65e5\u672c\uff09 <\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30e1\u30fc\u30ab\u30fc\uff0f\u30a6\u30a7\u30d6\u30b5\u30a4\u30c8<\/strong> <a href=\"https:\/\/www.novartis.com\/us-en\/sites\/novartis_us\/files\/kymriah.pdf\" target=\"_blank\" rel=\"noopener\">\u30ce\u30d0\u30eb\u30c6\u30a3\u30b9 \u30ad\u30e0\u30ea\u30a2<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>FDA\u306e\u88fd\u54c1\u30da\u30fc\u30b8\uff1a<\/strong> <a href=\"https:\/\/www.fda.gov\/vaccines-blood-biologics\/kymriah\" target=\"_blank\" rel=\"noopener\">FDA \u30ad\u30e0\u30ea\u30a2<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Axicabtagene_Ciloleucel_Yescarta%C2%AE_%E2%80%93_KiteGilead\"><\/span>\u30a2\u30af\u30b7\u30ab\u30d6\u30bf\u30b8\u30a7\u30f3\u30fb\u30b7\u30ed\u30ed\u30a4\u30bb\u30eb\uff08Yescarta\u00ae\uff09 - \uff08\u82f1\u8a9e <em>\u30ab\u30a4\u30c8\uff0f\u30ae\u30ea\u30a2\u30c9<\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6a19\u7684\u6297\u539f\uff1a<\/strong> CD19<br><strong>\u516c\u8a8d\uff1a<\/strong> FDA 2017\u5e7410\u6708\uff0fEMA 2018\u5e748\u6708<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u9069\u5fdc\u75c7<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>2\u7a2e\u985e\u4ee5\u4e0a\u306e\u5168\u8eab\u7642\u6cd5\u5f8c\u306e\u5927\u7d30\u80de\u578bB\u7d30\u80de\u30ea\u30f3\u30d1\u816b\uff08DLBCL\u3001PMBCL\u3001HGBCL\u3001tFL<\/li>\n\n\n\n<li>\u539f\u767a\u6027\u96e3\u6cbb\u6027DLBCL\u307e\u305f\u306f12\u30f5\u6708\u4ee5\u5185\u306e\u518d\u767a\uff082\u6b21\u6cbb\u7642\uff09<\/li>\n\n\n\n<li>2\u7a2e\u985e\u4ee5\u4e0a\u306e\u5168\u8eab\u7642\u6cd5\u5f8c\u306e\u518d\u767a\/\u96e3\u6cbb\u6027\u306e\u6ffe\u80de\u6027\u30ea\u30f3\u30d1\u816b<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6700\u3082\u91cd\u8981\u306a\u7814\u7a76<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>ZUMA-1\uff08LBCL\u3001ORR82 %\uff09\uff1a <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT02348216\" target=\"_blank\" rel=\"noopener\">NCT02348216<\/a> | <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1707447\" target=\"_blank\" rel=\"noopener\">NEJM 2017<\/a><\/li>\n\n\n\n<li>ZUMA-7\uff082\u6b21\u6cbb\u7642\u5bfeASCT\uff09\uff1a <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03391466\" target=\"_blank\" rel=\"noopener\">NCT03391466<\/a><\/li>\n\n\n\n<li>ZUMA-5\uff08\u6ffe\u80de\u6027\u30ea\u30f3\u30d1\u816b\u3001ORR&gt;90 %\uff09\uff1a <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03105336\" target=\"_blank\" rel=\"noopener\">NCT03105336<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6cbb\u7642\u30bb\u30f3\u30bf\u30fc\uff08D\/A\/CH\u30bb\u30ec\u30af\u30b7\u30e7\u30f3\uff09<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">FACT\/JACIE\u8a8d\u5b9a\u79fb\u690d\u30bb\u30f3\u30bf\u30fc\uff08\u30c9\u30a4\u30c4\u3067\u306f\u30cf\u30f3\u30d6\u30eb\u30af\u30fb\u30a8\u30c3\u30da\u30f3\u30c9\u30eb\u30d5\u5927\u5b66\u533b\u7642\u30bb\u30f3\u30bf\u30fc\u3001\u30d9\u30eb\u30ea\u30f3\u30fb\u30b7\u30e3\u30ea\u30c6\u3001\u30df\u30e5\u30f3\u30d8\u30f3\u5927\u5b66\u30af\u30ea\u30cb\u30af\u30e0\u3001\u30cf\u30a4\u30c7\u30eb\u30d9\u30eb\u30af\u5927\u5b66\u533b\u7642\u30bb\u30f3\u30bf\u30fc\u306a\u3069\uff09\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30e1\u30fc\u30ab\u30fc\/\u30a6\u30a7\u30d6\u30b5\u30a4\u30c8<\/strong>: <a href=\"https:\/\/www.yescarta.com\" target=\"_blank\" rel=\"noopener\">\u30ae\u30ea\u30a2\u30c9\u30fb\u30a4\u30a8\u30b9\u30ab\u30eb\u30bf<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Brexucabtagene_Autoleucel_Tecartus%C2%AE_%E2%80%93_KiteGilead\"><\/span>Brexucabtagene Autoleucel (Tecartus\u00ae) - \u30d6\u30ec\u30af\u30b9\u30ab\u30d6\u30bf\u30b8\u30a7\u30f3 \u30aa\u30fc\u30c8\u30ed\u30a4\u30bb\u30eb (Tecartus\u00ae) <em>\u30ab\u30a4\u30c8\uff0f\u30ae\u30ea\u30a2\u30c9<\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6a19\u7684\u6297\u539f\uff1a<\/strong> CD19<br><strong>\u516c\u8a8d\uff1a<\/strong> FDA 2020\u5e747\u6708\uff08MCL\uff09\u30012021\u5e7410\u6708\uff08\u6210\u4eba\u5168\u4f8b\uff09\uff0fEMA 2020\u5e7412\u6708<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u9069\u5fdc\u75c7<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>BTK\u963b\u5bb3\u5264\u6295\u4e0e\u5f8c\u306e\u518d\u767a\/\u96e3\u6cbb\u6027\u30de\u30f3\u30c8\u30eb\u7d30\u80de\u30ea\u30f3\u30d1\u816b\uff08MCL\uff09<\/li>\n\n\n\n<li>\u6210\u4eba\u518d\u767a\/\u96e3\u6cbb\u6027B\u7d30\u80de\u6027ALL<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6700\u3082\u91cd\u8981\u306a\u7814\u7a76<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>ZUMA-2\uff08MCL\u300112\u30f5\u6708OS\uff1a83 %\uff09\uff1a <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT02601313\" target=\"_blank\" rel=\"noopener\">NCT02601313<\/a><\/li>\n\n\n\n<li>ZUMA-3\uff08\u6210\u4ebaB-ALL\u3001OS\u4e2d\u592e\u502418.2\u30f5\u6708\uff09\uff1a <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT02614066\" target=\"_blank\" rel=\"noopener\">NCT02614066<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>FDA\u306e\u88fd\u54c1\u30da\u30fc\u30b8\uff1a<\/strong> <a href=\"https:\/\/www.fda.gov\/vaccines-blood-biologics\/tecartus\" target=\"_blank\" rel=\"noopener\">FDA\u30c6\u30ab\u30eb\u30bf\u30b9<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Lisocabtagene_Maraleucel_Breyanzi%C2%AE_%E2%80%93_Bristol_Myers_Squibb\"><\/span>\u30ea\u30be\u30ab\u30d6\u30bf\u30b8\u30a7\u30f3\u30fb\u30de\u30e9\u30ec\u30a6\u30bb\u30eb\uff08\u30d6\u30ea\u30a2\u30f3\u30c4\u30a3\u00ae\uff09 - Lisocabtagene Maraleucel (Breyanzi\u00ae) <em>\u30d6\u30ea\u30b9\u30c8\u30eb\u30fb\u30de\u30a4\u30e4\u30fc\u30ba \u30b9\u30af\u30a4\u30d6<\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6a19\u7684\u6297\u539f\uff1a<\/strong> CD19<br><strong>\u516c\u8a8d\uff1a<\/strong> FDA 2021\u5e742\u6708\uff08\u521d\u56de\uff09\uff0f\u9069\u5fdc\u62e1\u5927 2022\uff5e2024\u5e74\uff0fEMA 2022\u5e7410\u6708<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u9069\u5fdc\u75c7<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5927\u7d30\u80de\u578b B \u7d30\u80de\u6027\u30ea\u30f3\u30d1\u816b\uff08LBCL\u3001DLBCL\u3001HGBCL\u3001FL\uff09 2 \u7cfb\u7d71\u76ee\uff0b 3 \u7cfb\u7d71\u76ee<\/li>\n\n\n\n<li>BTK\u963b\u5bb3\u5264\u3092\u542b\u30802\u7a2e\u985e\u4ee5\u4e0a\u306e\u6cbb\u7642\u5f8c\u306e\u6162\u6027\u30ea\u30f3\u30d1\u6027\u767d\u8840\u75c5\uff08CLL\uff09\uff0f\u5c0f\u7d30\u80de\u30ea\u30f3\u30d1\u6027\u30ea\u30f3\u30d1\u816b\uff08SLL\uff09 \uff08FDA 2024\u5e74\uff09<\/li>\n\n\n\n<li>2\u7a2e\u985e\u4ee5\u4e0a\u306e\u5168\u8eab\u7642\u6cd5\u5f8c\u306e\u6ffe\u80de\u6027\u30ea\u30f3\u30d1\u816b\uff08FL\uff09<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6700\u3082\u91cd\u8981\u306a\u7814\u7a76<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>TRANSFORM\uff082\u6b21\u6cbb\u7642DLBCL\uff09\uff1a <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03575351\" target=\"_blank\" rel=\"noopener\">NCT03575351<\/a><\/li>\n\n\n\n<li>Transcend-CLL-004\uff08ClL\/SLL\uff09\uff1a <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03331198\" target=\"_blank\" rel=\"noopener\">NCT03331198<\/a> | <a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(24)00422-7\/fulltext\" target=\"_blank\" rel=\"noopener\">\u30e9\u30f3\u30bb\u30c3\u30c82024<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>FDA\u306e\u88fd\u54c1\u30da\u30fc\u30b8\uff1a<\/strong> <a href=\"https:\/\/www.fda.gov\/vaccines-blood-biologics\/breyanzi\" target=\"_blank\" rel=\"noopener\">FDA\u30d6\u30e9\u30a4\u30a2\u30f3\u30c4\u30a3<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Idecabtagene_Vicleucel_Abecma%C2%AE_%E2%80%93_Bristol_Myers_Squibb_2seventy_bio\"><\/span>\u30a4\u30c7\u30ab\u30d6\u30bf\u30b8\u30a7\u30f3\u30fb\u30d3\u30af\u30ec\u30eb\u30bb\u30eb\uff08\u30a2\u30d9\u30af\u30de\u00ae\uff09 - \u65e5\u672c <em>\u30d6\u30ea\u30b9\u30c8\u30eb\u30fb\u30de\u30a4\u30e4\u30fc\u30ba \u30b9\u30af\u30a4\u30d6 \/ 2seventy bio<\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6a19\u7684\u6297\u539f\uff1a<\/strong> BCMA\uff08B\u7d30\u80de\u6210\u719f\u6297\u539f\uff09<br><strong>\u516c\u8a8d\uff1a<\/strong> FDA 2021\u5e743\u6708\uff0fEMA 2021\u5e748\u6708<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u8868\u793a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>4\u7a2e\u985e\u4ee5\u4e0a\u306e\u6cbb\u7642\u6b74\u3092\u6709\u3059\u308b\u518d\u767a\/\u96e3\u6cbb\u6027\u306e\u591a\u767a\u6027\u9aa8\u9ac4\u816b<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6700\u3082\u91cd\u8981\u306a\u7814\u7a76<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>KarMMa\u8a66\u9a13\uff08ORR 73 %\uff09\uff1a <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03361748\" target=\"_blank\" rel=\"noopener\">NCT03361748<\/a> | <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2024850\" target=\"_blank\" rel=\"noopener\">NEJM 2021<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>FDA\u306e\u88fd\u54c1\u30da\u30fc\u30b8\uff1a<\/strong> <a href=\"https:\/\/www.fda.gov\/vaccines-blood-biologics\/abecma\" target=\"_blank\" rel=\"noopener\">FDA\u30a2\u30d9\u30c3\u30af\u30de<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Ciltacabtagene_Autoleucel_Carvykti%C2%AE_%E2%80%93_JanssenLegend_Biotech\"><\/span>\u30c1\u30eb\u30bf\u30ab\u30d6\u30bf\u30b8\u30a7\u30f3\u30cc\u30fb\u30aa\u30fc\u30c8\u30ea\u30e5\u30fc\u30bb\u30eb\uff08Carvykti\u00ae\uff09-\u3002 <em>\u30e4\u30f3\u30bb\u30f3\uff0f\u30ec\u30b8\u30a7\u30f3\u30c9\u30fb\u30d0\u30a4\u30aa\u30c6\u30c3\u30af<\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6a19\u7684\u6297\u539f\uff1a<\/strong> BCMA\uff08\u30c7\u30e5\u30a2\u30eb\u30d0\u30a4\u30f3\u30c7\u30a3\u30f3\u30b0\uff09<br><strong>\u516c\u8a8d\uff1a<\/strong> FDA 2022\u5e742\u6708\uff084\u30e9\u30a4\u30f3\u4ee5\u4e0a\uff09\u30012024\u5e744\u6708\u5ef6\u9577\uff081\u30e9\u30a4\u30f3\u4ee5\u4e0a\uff09 \/ EMA 2022\u5e745\u6708<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7279\u96c6\uff1a<\/strong> 2\u3064\u306eBCMA\u7d50\u5408\u30b7\u30f3\u30b0\u30eb\u30c9\u30e1\u30a4\u30f3\u6297\u4f53\u3092\u6709\u3059\u308b\u30e6\u30cb\u30fc\u30af\u306a\u30c7\u30e5\u30a2\u30eb\u6297\u4f53CAR\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u9069\u5fdc\u75c7<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>4\u30e9\u30a4\u30f3\u4ee5\u4e0a\u306e\u6cbb\u7642\u5f8c\u306e\u518d\u767a\/\u96e3\u6cbb\u6027\u591a\u767a\u6027\u9aa8\u9ac4\u816b<\/li>\n\n\n\n<li>2024\u5e744\u6708\u4ee5\u964d\uff08FDA\uff09\uff1a\u30ec\u30ca\u30ea\u30c9\u30df\u30c9\u4e0d\u5fdc\u75c7\u306b\u5bfe\u3059\u308b1\u30e9\u30a4\u30f3\u4ee5\u4e0a\u306e\u6cbb\u7642\u5f8c<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6700\u3082\u91cd\u8981\u306a\u7814\u7a76<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Cartitude-1\uff08ORR 98 %\u3001CR 78 %\uff09\uff1a <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03548207\" target=\"_blank\" rel=\"noopener\">NCT03548207<\/a> | <a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(21)00933-4\/fulltext\" target=\"_blank\" rel=\"noopener\">\u30e9\u30f3\u30bb\u30c3\u30c82021<\/a><\/li>\n\n\n\n<li>CARTITUDE-4\uff08\u30d5\u30a7\u30fc\u30ba3\u30011\u56de\u76ee\u306e\u518d\u767a\u306e\u5ef6\u9577\uff09\uff1a <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04181827\" target=\"_blank\" rel=\"noopener\">NCT04181827<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>FDA\u306e\u88fd\u54c1\u30da\u30fc\u30b8\uff1a<\/strong> <a href=\"https:\/\/www.fda.gov\/vaccines-blood-biologics\/carvykti\" target=\"_blank\" rel=\"noopener\">FDA\u30ab\u30fc\u30f4\u30a3\u30af\u30c6\u30a3<\/a><br><strong>\u30e1\u30fc\u30ab\u30fc<\/strong> <a href=\"https:\/\/www.carvykti.com\" target=\"_blank\" rel=\"noopener\">carvykti.com<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Obecabtagene_Autoleucel_Aucatzyl%C2%AE_%E2%80%93_Autolus_neu_112024\"><\/span>\u30aa\u30d9\u30ab\u30d6\u30bf\u30b8\u30a7\u30f3\u30cc\u30fb\u30aa\u30fc\u30c8\u30ed\u30a4\u30bb\u30eb\uff08Aucatzyl\u00ae\uff09 - \uff08\u82f1\u8a9e <em>\u30aa\u30fc\u30c8\u30e9\u30b9<\/em> <em>(\u65b0\uff1a11.2024)<\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6a19\u7684\u6297\u539f\uff1a<\/strong> CD19\uff08\u30d5\u30a1\u30b9\u30c8\u30aa\u30d5\u30ec\u30fc\u30c8\u8a2d\u8a08 - \u5f93\u6765\u54c1\u3088\u308a\u6bd2\u6027\u304c\u4f4e\u3044\uff09<br><strong>\u516c\u8a8d\uff1a<\/strong> FDA 2024\u5e7411\u67088\u65e5<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u8868\u793a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6210\u4eba\u518d\u767a\/\u96e3\u6cbb\u6027B\u7d30\u80de\u6027ALL<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7279\u96c6\uff1a<\/strong> REMS\uff08\u30ea\u30b9\u30af\u8a55\u4fa1\u30fb\u8efd\u6e1b\u6226\u7565\uff09\u30d7\u30ed\u30b0\u30e9\u30e0\u306a\u3057\u3067\u627f\u8a8d\u3055\u308c\u305f\u521d\u3081\u3066\u306eCAR-T\u88fd\u5264\u3067\u3042\u308a\u3001\u5b89\u5168\u6027\u306e\u5411\u4e0a\u3068\u65b0\u898fCD19\u7d50\u5408\u30b3\u30f3\u30bb\u30d7\u30c8\u306e\u8868\u308c\u3067\u3042\u308b\u3002.<br><a href=\"https:\/\/www.dasgelbeblatt.de\/welt\/immunzelltherapie-heilt-ueberraschend-krebs-bei-einem-jugendlichen-zr-94168662.html\" target=\"_blank\" rel=\"noreferrer noopener\">\u9ec4\u8272\u3044\u8449<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6700\u3082\u91cd\u8981\u306a\u7814\u7a76<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>FELIX\u8a66\u9a13\uff08\u30d5\u30a7\u30fc\u30ba1\/2\u30013\u30f5\u6708CR\u738742 %\uff09\uff1a <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04404660\" target=\"_blank\" rel=\"noopener\">NCT04404660<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>FDA\u306e\u88fd\u54c1\u30da\u30fc\u30b8\uff1a<\/strong> <a href=\"https:\/\/www.fda.gov\/vaccines-blood-biologics\/aucatzyl\" target=\"_blank\" rel=\"noopener\">FDA\u30aa\u30fc\u30ab\u30c4\u30a3\u30eb<\/a><br><strong>\u30e1\u30fc\u30ab\u30fc<\/strong> <a href=\"https:\/\/www.autolus.com\" target=\"_blank\" rel=\"noopener\">\u30aa\u30fc\u30c8\u30e9\u30b9\u30fb\u30c9\u30c3\u30c8\u30b3\u30e0<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"WELTWEIT_ZUGELASSEN_%E2%80%93_NICHT_IN_USAEU_weitere_Lander\"><\/span>\u30ef\u30fc\u30eb\u30c9\u30ef\u30a4\u30c9\u3067\u4f7f\u7528\u53ef\u80fd - USA\/EU\uff08\u305d\u306e\u4ed6\u306e\u56fd\uff09\u3067\u306f\u4f7f\u7528\u4e0d\u53ef<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"China_NMPA_%E2%80%93_vier_zusatzliche_CAR-T-Produkte\"><\/span>\u4e2d\u56fd\uff08NMPA\uff09-4\u3064\u306eCAR-T\u88fd\u54c1\u304c\u8ffd\u52a0\u3055\u308c\u308b<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u5408\u8a0811\u306e\u81ea\u5df1CAR-T\u7d30\u80de\u7642\u6cd5\u304c\u4e16\u754c\u3067\u6700\u521d\u306e\u627f\u8a8d\u3092\u53d7\u3051\u305f\u3002FDA\u304c7\u3064\u3001\u4e2d\u56fd\u306eNMPA\u304c4\u3064\u3067\u3001\u3044\u305a\u308c\u3082\u518d\u767a\uff0f\u96e3\u6cbb\u6027\u306e\u8840\u6db2\u60aa\u6027\u816b\u760d\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3044\u308b\u3002.<br><a href=\"https:\/\/ucla.clinicaltrials.researcherprofiles.org\/trial\/NCT06743126\" target=\"_blank\" rel=\"noreferrer noopener\">\u30a4\u30de\u30c6\u30a3\u30af\u30b9US\u793e.<\/a><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u5546\u54c1\u540d<\/th><th>\u6709\u52b9\u6210\u5206<\/th><th>\u6a19\u7684\u6297\u539f<\/th><th>\u8868\u793a<\/th><th>\u8a8d\u53ef<\/th><\/tr><\/thead><tbody><tr><td>\u30ab\u30eb\u30c6\u30a4\u30d0<\/td><td>\u30ec\u30eb\u30de\u30ab\u30d6\u30bf\u30b8\u30a7\u30f3\u30cc\u30fb\u30aa\u30fc\u30c8\u30ea\u30e5\u30fc\u30bb\u30eb<\/td><td>BCMA<\/td><td>\u30de\u30eb\u30c1\u9aa8\u9ac4\u816b\u3001DLBCL<\/td><td>NMPA 2021\/2023<\/td><\/tr><tr><td>\u30d5\u30ab\u30bd<\/td><td>\u30a8\u30af\u30ab\u30d6\u30bf\u30b8\u30a7\u30f3\u30cc\u30fb\u30aa\u30fc\u30c8\u30ea\u30e5\u30fc\u30bb\u30eb<\/td><td>BCMA<\/td><td>\u30de\u30eb\u30c1\u9aa8\u9ac4\u816b<\/td><td>NMPA 2023<\/td><\/tr><tr><td>\u30e6\u30a2\u30f3\u30eb\u30a4\u30c0<\/td><td>\u30b5\u30c8\u30ea\u30ab\u30d6\u30bf\u30b8\u30fc\u30f3\u30fb\u30aa\u30fc\u30c8\u30ea\u30e5\u30fc\u30bb\u30eb<\/td><td>CD19<\/td><td>B\u7d30\u80de\u30ea\u30f3\u30d1\u816b<\/td><td>NMPA<\/td><\/tr><tr><td>\u30bc\u30f4\u30a1\u30fc\u30bb\u30eb<\/td><td>\u2014<\/td><td>CD19\/BCMA<\/td><td>\u8840\u6db2\u5b66.<\/td><td>NMPA<\/td><\/tr><tr><td>\u30ab\u30fc\u30f4\u30a3\u30fc\u30af\u30c6\u30a3<\/td><td>\u30c1\u30eb\u30bf\u30ab\u30d6\u30bf\u30b8\u30fc\u30f3\u30fb\u30aa\u30fc\u30c8\u30ea\u30e5\u30fc\u30bb\u30eb<\/td><td>BCMA<\/td><td>\u30de\u30eb\u30c1\u9aa8\u9ac4\u816b<\/td><td>NMPA 2024<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Indien_CDSCO\"><\/span>\u30a4\u30f3\u30c9\uff08CDSCO\uff09<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30cd\u30af\u30b9\u30ab\u30fc19<\/strong> (Actalycabtagene autoleucel\uff09\u304c\u3001\u30a4\u30f3\u30c9\u3067\u958b\u767a\u3055\u308c\u305f\u6700\u521d\u306eCAR-T\u7642\u6cd5\u3068\u3057\u30662023\u5e7410\u6708\u306b\u627f\u8a8d\u3055\u308c\u305f\u3002IIT\u30dc\u30f3\u30d9\u30a4\u6821\u306e\u30a4\u30e0\u30ce\u30a2\u30af\u30c8\u304c\u958b\u767a\u3057\u305f\u3053\u306e\u6cbb\u7642\u6cd5\u306e\u4fa1\u683c\u306f\u7d045\u4e07\u30c9\u30eb\u3067\u3001\u6b27\u7c73\u306e\u540c\u7b49\u88fd\u54c1\u306e\u7d0410\u5206\u306e1\u3067\u3042\u308b\u3002. <a href=\"https:\/\/www.dasgelbeblatt.de\/welt\/immunzelltherapie-heilt-ueberraschend-krebs-bei-einem-jugendlichen-zr-94168662.html\" target=\"_blank\" rel=\"noreferrer noopener\">\u9ec4\u8272\u3044\u8449<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u8868\u793a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u518d\u767a\/\u96e3\u6cbb\u6027\u306eB\u7d30\u80de\u6027\u975e\u30db\u30b8\u30ad\u30f3\u30ea\u30f3\u30d1\u816b\u304a\u3088\u3073B\u7d30\u80de\u6027ALL<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6cbb\u7642\u30bb\u30f3\u30bf\u30fc\uff1a<\/strong> \u30bf\u30bf\u8a18\u5ff5\u75c5\u9662\uff08\u30e0\u30f3\u30d0\u30a4 <br><strong>\u30e1\u30fc\u30ab\u30fc<\/strong> <a href=\"https:\/\/www.immunoact.com\" target=\"_blank\" rel=\"noopener\">\u30a4\u30e0\u30ce\u30a2\u30af\u30c8<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"TCR-T-ZELLTHERAPIEN_zugelassen\"><\/span>TCR-T\u7d30\u80de\u7642\u6cd5\uff08\u516c\u8a8d\uff09<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Afamitresgene_Autoleucel_Tecelra%C2%AE_%E2%80%93_Adaptimmune_August_2024\"><\/span>\u30a2\u30d5\u30a1\u30df\u30c8\u30ec\u30b9\u30b8\u30fc\u30f3\u30fb\u30aa\u30fc\u30c8\u30ea\u30e5\u30fc\u30bb\u30eb\uff08\u30c6\u30bb\u30eb\u30e9\u00ae\uff09 - \uff08\u82f1\u8a9e <em>\u30a2\u30c0\u30d7\u30c6\u30a3\u30df\u30e5\u30fc\u30f3<\/em> <em>(2024\u5e748\u6708\uff09<\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">2024\u5e748\u67082\u65e5\u3001FDA\u306fAfamitresgene autoleucel\uff08Afami-cel\u3001Tecelra\u793e\uff09\u3092\u53f2\u4e0a\u521d\u306e\u304c\u3093\u6cbb\u7642\u7528TCR T\u7d30\u80de\u7642\u6cd5\u3068\u3057\u3066\u3001\u7279\u306b\u56fa\u5f62\u304c\u3093\u306b\u5bfe\u3059\u308b\u521d\u306e\u907a\u4f1d\u5b50\u64cd\u4f5cT\u7d30\u80de\u88fd\u5264\u3068\u3057\u3066\u627f\u8a8d\u3057\u305f\u3002. <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12283372\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u30d1\u30d6\u30e1\u30c9\u30bb\u30f3\u30c8\u30e9\u30eb<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6a19\u7684\u6297\u539f\uff1a<\/strong> HLA-A*02:01\u304c\u63d0\u793a\u3059\u308bMAGE-A4\uff08\u7d30\u80de\u5185\u304c\u3093\u7cbe\u5de3\u6297\u539f<br><strong>\u516c\u8a8d\uff1a<\/strong> FDA 2024\u5e748\u6708<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u8868\u793a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5207\u9664\u4e0d\u80fd\u307e\u305f\u306f\u8ee2\u79fb\u306e\u3042\u308b\u6210\u4eba\u304c\u3093 <strong>\u6ed1\u819c\u8089\u816b<\/strong> (\u8edf\u90e8\u8089\u816b\uff09\u3001\u5316\u5b66\u7642\u6cd5\u524d\u6cbb\u7642\u3001MAGE-A4\u967d\u6027\u3001HLA-A*02:01\u967d\u6027<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u6975\u3081\u3066\u91cd\u8981\u306a\u7b2c2\u76f8SPEARHEAD-1\u8a66\u9a13\u3067\u306f\u3001\u6ed1\u819c\u8089\u816b\u60a3\u8005\u306e\u816b\u760d\u306f\u4e2d\u592e\u5024\u306711.6\u30f5\u6708\u9593\u6cbb\u7642\u306b\u53cd\u5fdc\u3057\u305f\u3002\u4e00\u90e8\u306e\u60a3\u8005\u3067\u306f\u6570\u5e74\u9593\u816b\u760d\u304c\u691c\u51fa\u3055\u308c\u306a\u304b\u3063\u305f\u3002. <a href=\"https:\/\/www.clinicaltrialvanguard.com\/news\/t-knife-files-for-phase-1-trial-of-prame-t-cell-therapy\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u30af\u30ea\u30cb\u30ab\u30eb\u30c8\u30e9\u30a4\u30a2\u30eb\u30d0\u30f3\u30ac\u30fc\u30c9<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6700\u3082\u91cd\u8981\u306a\u7814\u7a76<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>SPEARHEAD-1\uff08\u30d5\u30a7\u30fc\u30ba2\uff09\uff1a <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04044858\" target=\"_blank\" rel=\"noopener\">NCT04044858<\/a> | <a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(24)00319-2\/fulltext\" target=\"_blank\" rel=\"noopener\">\u30e9\u30f3\u30bb\u30c3\u30c82024\u5e744\u6708\u53f7<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6cbb\u7642\u30bb\u30f3\u30bf\u30fc\uff08\u30d1\u30a4\u30aa\u30cb\u30a2\uff09\uff1a<\/strong> \u30e1\u30e2\u30ea\u30a2\u30eb\u30fb\u30b9\u30ed\u30fc\u30f3\u30fb\u30b1\u30bf\u30ea\u30f3\u30b0\u304c\u3093\u30bb\u30f3\u30bf\u30fc\uff08\u30cb\u30e5\u30fc\u30e8\u30fc\u30af <a href=\"https:\/\/www.mskcc.org\/news\/immunotherapy-clinical-trial-shows-promise-for-treating-rare-sarcomas\" target=\"_blank\" rel=\"noopener\">MSK\u30c6\u30bb\u30e9\u60c5\u5831<\/a><br><strong>FDA\u306e\u88fd\u54c1\u30da\u30fc\u30b8\uff1a<\/strong> <a href=\"https:\/\/www.fda.gov\/vaccines-blood-biologics\/tecelra\" target=\"_blank\" rel=\"noopener\">FDA\u30c6\u30bb\u30e9<\/a> <br><strong>NCI\u306e\u8a18\u4e8b\uff1a<\/strong> <a href=\"https:\/\/www.cancer.gov\/news-events\/cancer-currents-blog\/2024\/fda-tecelra-synovial-sarcoma-mage-a4\" target=\"_blank\" rel=\"noopener\">cancer.gov TCR\u7642\u6cd5<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Tebentafusp-tebn_Kimmtrak%C2%AE_%E2%80%93_Immunocore_Januar_2022\"><\/span>\u30c6\u30d9\u30f3\u30bf\u30d5\u30b9\u30d7\u30c6\u30d6\u30f3\uff08\u30ad\u30f3\u30e0\u30c8\u30e9\u30c3\u30af\u00ae\uff09 - Kimmtrak\u00ae - Tebentafusp-tebn <em>\u30a4\u30e0\u30ce\u30b3\u30a2<\/em> <em>(2022\u5e741\u6708\uff09<\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u53e4\u5178\u7684\u306a\u7d30\u80de\u88fd\u54c1\u3067\u306f\u306a\u304f\uff08T\u7d30\u80de\u8f38\u6ce8\u88fd\u54c1\u3067\u306f\u306a\u3044\uff09\u3001\u4e8c\u91cd\u7279\u7570\u6027TCR\u878d\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b\u304c\u3001\u30e1\u30ab\u30cb\u30ba\u30e0\u7684\u306b\u306fTCR\u30d9\u30fc\u30b9\u306e\u514d\u75ab\u7642\u6cd5\u306e\u7bc4\u7587\u306b\u3042\u308a\u3001\u3057\u3070\u3057\u3070PRAME-TCER\u00ae\u6280\u8853\u306e\u5148\u99c6\u3051\u3068\u3057\u3066\u8b70\u8ad6\u3055\u308c\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30e1\u30ab\u30cb\u30ba\u30e0<\/strong> \u4e00\u65b9\u306f\u816b\u760d\u7d30\u80de\u4e0a\u306egp100\u30da\u30d7\u30c1\u30c9+HLA-A*02:01\u306b\u7d50\u5408\u3057\u3001\u3082\u3046\u4e00\u65b9\u306fT\u7d30\u80de\u4e0a\u306eCD3\u306b\u7d50\u5408\u3059\u308b\uff08ImmTAC\u6280\u8853\uff09\u3002.<br><strong>\u516c\u8a8d\uff1a<\/strong> FDA 2022\u5e741\u6708\uff0fEMA 2022\u5e742\u6708<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u8868\u793a\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5207\u9664\u4e0d\u80fd\u307e\u305f\u306f\u8ee2\u79fb\u764c\u306eHLA-A*02:01\u967d\u6027\u6210\u4eba\u60a3\u8005 <strong>\u3076\u3069\u3046\u819c\u9ed2\u8272\u816b<\/strong> (\u773c\u90e8\u9ed2\u8272\u816b\uff09-1st line<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7279\u96c6\uff1a<\/strong> \u30d6\u30c9\u30a6\u819c\u9ed2\u8272\u816b\u306b\u53f2\u4e0a\u521d\u306e\u65b0\u85ac\u627f\u8a8d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7b2c3\u76f8IMCgp100-202\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u30c6\u30d9\u30f3\u30bf\u30d5\u30b9\u30d7\u306f\u533b\u5e2b\u306e\u9078\u629e\uff08\u30da\u30e0\u30d6\u30ed\u30ea\u30ba\u30de\u30d6\u3001\u30a4\u30d4\u30ea\u30e0\u30de\u30d6\u3001\u30c0\u30ab\u30eb\u30d0\u30b8\u30f3\uff09\u306b\u5bfe\u3057\u3066\u6709\u610f\u306a\u751f\u5b58\u671f\u9593\u306e\u5ef6\u9577\u3092\u793a\u3057\u305f\uff1aOS\u4e2d\u592e\u502421.7\u30ab\u6708\u5bfe16.0\u30ab\u6708\uff08HR 0.51\u3001p&lt;0.0001\uff09\u30021\u5e74OS\u7387\u306f%\u7fa473\u4f8b\u5bfe%\u7fa459\u4f8b\u3067\u3042\u3063\u305f\u3002. <a href=\"https:\/\/www.kitz-heidelberg.de\/das-kitz\/kitz-programme\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u30ad\u30c3\u30c4\u30fb\u30cf\u30a4\u30c7\u30eb\u30d9\u30eb\u30af<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6700\u3082\u91cd\u8981\u306a\u7814\u7a76<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>IMCgp100-202\uff08\u30d5\u30a7\u30fc\u30ba3\uff09\uff1a <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03070392\" target=\"_blank\" rel=\"noopener\">NCT03070392<\/a> | <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2103485\" target=\"_blank\" rel=\"noopener\">NEJM 2021<\/a> | <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2304753\" target=\"_blank\" rel=\"noopener\">3\u5e74\u66f4\u65b0 NEJM 2023<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>FDA\u306e\u30da\u30fc\u30b8\uff1a<\/strong> <a href=\"https:\/\/www.fda.gov\/drugs\/resources-information-approved-drugs\/fda-disco-burst-edition-fda-approves-tebentafusp-tebn-unresectable-or-metastatic-uveal-melanoma\" target=\"_blank\" rel=\"noopener\">fda.gov \u30ad\u30e0\u30c8\u30e9\u30c3\u30af<\/a> <br><strong>\u30e1\u30fc\u30ab\u30fc<\/strong> <a href=\"https:\/\/www.immunocore.com\/pipeline\/kimmtrak\" target=\"_blank\" rel=\"noopener\">immunocore.com\/kimmtrak<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"TIL-THERAPIE_zugelassen\"><\/span>TIL-THERAPY\uff08\u8a8d\u53ef\u6e08\u307f\uff09<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Lifileucel_Amtagvi%C2%AE_%E2%80%93_Iovance_Biotherapeutics_Februar_2024\"><\/span>\u30ea\u30d5\u30a3\u30ea\u30e5\u30fc\u30bb\u30eb\uff08\u30a2\u30e0\u30bf\u30b0\u30d3\u00ae\uff09 - Lifileucel (Amtagvi\u00ae) <em>\u30a2\u30a4\u30aa\u30d0\u30f3\u30b9\u30fb\u30d0\u30a4\u30aa\u30bb\u30e9\u30d4\u30e5\u30fc\u30c6\u30a3\u30af\u30b9<\/em> <em>(2024\u5e742\u6708\uff09<\/em><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u30ea\u30d5\u30a3\u30ea\u30e5\u30fc\u30bb\u30eb\u306f2024\u5e742\u670816\u65e5\u3001\u56fa\u5f62\u304c\u3093\u306b\u5bfe\u3059\u308b\u53f2\u4e0a\u521d\u306eT\u7d30\u80de\u7642\u6cd5\u3068\u3057\u3066\u3001\u307e\u305f\u53f2\u4e0a\u521d\u306eTIL\u7642\u6cd5\u3068\u3057\u3066\u627f\u8a8d\u3055\u308c\u305f\u3002. <a href=\"https:\/\/investors.immatics.com\/news-releases\/news-release-details\/immatics-initiates-phase-12-clinical-trial-evaluate-prame-tcr\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u30a4\u30de\u30c6\u30a3\u30af\u30b9N.V.<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30e1\u30ab\u30cb\u30ba\u30e0<\/strong> \u816b\u760d\u3092\u5916\u79d1\u7684\u306b\u5207\u9664\u3057\u3001\u816b\u760d\u6d78\u6f64\u30ea\u30f3\u30d1\u7403\uff08TIL\uff09\u3092\u5358\u96e2\u3057\u3001\u5927\u91cf\u5897\u6b96\u3055\u305b\u3001\u30ea\u30f3\u30d1\u7403\u9664\u53bb\u5f8c\u306b\u518d\u6ce8\u5165\u3059\u308b\u3002\u907a\u4f1d\u5b50\u7d44\u307f\u63db\u3048\u306f\u884c\u308f\u305a\u3001TIL\u306e\u81ea\u7136\u306a\u816b\u760d\u8a8d\u8b58\u304c\u5229\u7528\u3055\u308c\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u8868\u793a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5207\u9664\u4e0d\u80fd\u307e\u305f\u306f\u8ee2\u79fb\u306e\u3042\u308b\u6210\u4eba\u304c\u3093 <strong>\u30e1\u30e9\u30ce\u30fc\u30de<\/strong> (\u6297PD-1\u7642\u6cd5\u304a\u3088\u3073BRAF\/MEK\u963b\u5bb3\u5264\uff08BRAF\u907a\u4f1d\u5b50\u5909\u7570\u306e\u5834\u5408\uff09\u524d\u6cbb\u7642\u5f8c\u306e\uff08\u76ae\u819a\u30e1\u30e9\u30ce\u30fc\u30de\uff09<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u7b2c2\u76f8\u81e8\u5e8a\u8a66\u9a13C-144-01\u306e5\u5e74\u9593\u306e\u8ffd\u8de1\u8abf\u67fb\u306b\u304a\u3044\u3066\u3001\u30ea\u30d5\u30a3\u30ea\u30e5\u30fc\u30bb\u30eb\u306f31.4 %\u306e\u5ba2\u89b3\u7684\u594f\u52b9\u7387\u3001\u594f\u52b9\u671f\u9593\u4e2d\u592e\u502436.5\u30ab\u6708\u3092\u793a\u3057\u300130\u4eba\u4ee5\u4e0a\u306e%\u594f\u52b9\u8005\u3067\u9577\u671f\u306b\u308f\u305f\u308b\u594f\u52b9\u304c\u6301\u7d9a\u3057\u305f\u3002. <a href=\"https:\/\/dailyreporter.esmo.org\/esmo-immuno-oncology-congress-2025\/news\/next-generation-prame-directed-tcr-t-cell-therapy-shows-early-activity-in-solid-tumours\" target=\"_blank\" rel=\"noreferrer noopener\">\u30a8\u30b9\u30e2<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6700\u3082\u91cd\u8981\u306a\u7814\u7a76<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>C-144-01\uff08\u30d5\u30a7\u30fc\u30ba2\u3001NCT02360579\uff09\uff1a <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT02360579\" target=\"_blank\" rel=\"noopener\">\u81e8\u5e8a\u8a66\u9a13<\/a> | <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40699950\/\" target=\"_blank\" rel=\"noopener\">FDA\u627f\u8a8d\u6982\u8981 PubMed<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6cbb\u7642\u30bb\u30f3\u30bf\u30fc\uff08\u7c73\u56fd\u9078\u629e\uff09\uff1a<\/strong> \u30b8\u30e7\u30f3\u30ba\u30fb\u30db\u30d7\u30ad\u30f3\u30b9\u3001UCLA\u3001MD\u30a2\u30f3\u30c0\u30fc\u30bd\u30f3\u3001UCSF\u3001\u30e1\u30e2\u30ea\u30a2\u30eb\u30fb\u30b9\u30ed\u30fc\u30f3\u30fb\u30b1\u30bf\u30ea\u30f3\u30b0\u3001\u30e1\u30a4\u30e8\u30fc\u30fb\u30af\u30ea\u30cb\u30c3\u30af<br><strong>NCI\u306e\u8a18\u4e8b\uff1a<\/strong> <a href=\"https:\/\/www.cancer.gov\/news-events\/cancer-currents-blog\/2024\/fda-amtagvi-til-therapy-melanoma\" target=\"_blank\" rel=\"noopener\">cancer.gov TIL\u7642\u6cd5<\/a><br><strong>\u30e1\u30fc\u30ab\u30fc<\/strong> <a href=\"https:\/\/www.iovance.com\" target=\"_blank\" rel=\"noopener\">\u30a2\u30a4\u30aa\u30d0\u30f3\u30b9\u30c9\u30c3\u30c8\u30b3\u30e0<\/a><br><strong>FDA\u306e\u88fd\u54c1\u30da\u30fc\u30b8\uff1a<\/strong> <a href=\"https:\/\/www.fda.gov\/vaccines-blood-biologics\/amtagvi\" target=\"_blank\" rel=\"noopener\">FDA\u30a2\u30e0\u30bf\u30b0\u30f4\u30a3<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Ubersicht_aller_Immunzelltherapien_weltweit\"><\/span>\u5168\u4e16\u754c\u306e\u514d\u75ab\u7d30\u80de\u6cbb\u7642\u306e\u6982\u8981<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u88fd\u54c1<\/th><th>\u6709\u52b9\u6210\u5206<\/th><th>\u30bf\u30a4\u30d7<\/th><th>\u30b4\u30fc\u30eb<\/th><th>\u8868\u793a<\/th><th>\u8a8d\u53ef<\/th><th>\u5e74<\/th><\/tr><\/thead><tbody><tr><td><strong>\u30ad\u30e0\u30ea\u30a2<\/strong><\/td><td>\u30c6\u30a3\u30b5\u30b2\u30f3\u30ec\u30ad\u30e5\u30bb\u30eb<\/td><td>CAR-T<\/td><td>CD19<\/td><td>\u5c0f\u5150B-ALL\u3001LBCL\u3001FL<\/td><td>FDA\u3001EMA<\/td><td>2017<\/td><\/tr><tr><td><strong>\u30a4\u30a8\u30b9\u30ab\u30eb\u30bf<\/strong><\/td><td>\u30a2\u30af\u30b7\u30ab\u30d6\u30bf\u30b8\u30a7\u30f3\u30bb\u30eb<\/td><td>CAR-T<\/td><td>CD19<\/td><td>DLBCL\u3001PMBCL\u3001FL\u3001tFL<\/td><td>FDA\u3001EMA<\/td><td>2017<\/td><\/tr><tr><td><strong>\u30c6\u30ab\u30eb\u30bf\u30b9<\/strong><\/td><td>\u30d6\u30ec\u30af\u30b9\u30ab\u30d6\u30bf\u30b8\u30a7\u30f3\u30bb\u30eb<\/td><td>CAR-T<\/td><td>CD19<\/td><td>MCL\u3001\u6210\u4ebaB-ALL<\/td><td>FDA\u3001EMA<\/td><td>2020<\/td><\/tr><tr><td><strong>\u30d6\u30ec\u30e4\u30f3\u30c4\u30a3<\/strong><\/td><td>\u30ea\u30be\u30ab\u30d6\u30bf\u30b8\u30a7\u30f3\u30bb\u30eb<\/td><td>CAR-T<\/td><td>CD19<\/td><td>LBCL\u3001CLL\/SLL\u3001FL<\/td><td>FDA\u3001EMA<\/td><td>2021<\/td><\/tr><tr><td><strong>\u30a2\u30d9\u30c3\u30af\u30de<\/strong><\/td><td>\u30a4\u30c7\u30ab\u30d6\u30bf\u30b8\u30a7\u30f3\u30bb\u30eb<\/td><td>CAR-T<\/td><td>BCMA<\/td><td>\u591a\u767a\u6027\u3002\u9aa8\u9ac4\u816b 4 \u30e9\u30a4\u30f3\u4ee5\u4e0a<\/td><td>FDA\u3001EMA<\/td><td>2021<\/td><\/tr><tr><td><strong>\u30ab\u30fc\u30f4\u30a3\u30fc\u30af\u30c6\u30a3<\/strong><\/td><td>\u30c1\u30eb\u30bf\u30ab\u30d6\u30bf\u30b8\u30a7\u30f3\u30bb\u30eb<\/td><td>CAR-T<\/td><td>BCMA<\/td><td>\u591a\u767a\u6027\u3002\u9aa8\u9ac4\u816b 1 \u30e9\u30a4\u30f3\u4ee5\u4e0a<\/td><td>FDA\u3001EMA\u3001NMPA<\/td><td>2022<\/td><\/tr><tr><td><strong>\u30ad\u30e0\u30c8\u30e9\u30c3\u30af<\/strong><\/td><td>\u30c6\u30d9\u30f3\u30bf\u30d5\u30b9\u30d7\u30c6\u30d6\u30f3<\/td><td>TCR\u4e8c\u91cd\u7279\u7570\u6027<\/td><td>gp100+HLA<\/td><td>\u3076\u3069\u3046\u819c\u9ed2\u8272\u816b<\/td><td>FDA\u3001EMA<\/td><td>2022<\/td><\/tr><tr><td><strong>\u30cd\u30af\u30b9\u30ab\u30fc19<\/strong><\/td><td>\u30a2\u30af\u30bf\u30ea\u30ab\u30d6\u30bf\u30b8\u30a7\u30f3\u30bb\u30eb<\/td><td>CAR-T<\/td><td>CD19<\/td><td>B-ALL, NHL<\/td><td>CDSCO\uff08\u30a4\u30f3\u30c9\uff09<\/td><td>2023<\/td><\/tr><tr><td><strong>\u30a2\u30e0\u30bf\u30b0\u30f4\u30a3<\/strong><\/td><td>\u30ea\u30d5\u30a3\u30ea\u30e5\u30fc\u30bb\u30eb<\/td><td>TIL<\/td><td>\u30dd\u30ea\u30af\u30ed\u30fc\u30ca\u30eb<\/td><td>\u9ed2\u8272\u816b\uff08\u56fa\u5f62\u816b\u760d\uff09<\/td><td>\u98df\u54c1\u533b\u85ac\u54c1\u5c40<\/td><td>2024<\/td><\/tr><tr><td><strong>\u30c6\u30bb\u30e9<\/strong><\/td><td>\u30a2\u30d5\u30a1\u30df\u30c8\u30ec\u30b9\u30b2\u30f3\u30bb\u30eb<\/td><td>TCR-T<\/td><td>MAGE-A4+HLA<\/td><td>\u6ed1\u819c\u8089\u816b<\/td><td>\u98df\u54c1\u533b\u85ac\u54c1\u5c40<\/td><td>2024<\/td><\/tr><tr><td><strong>\u30a2\u30a6\u30ab\u30c4\u30a3\u30eb<\/strong><\/td><td>\u30aa\u30d9\u30ab\u30d6\u30bf\u30b8\u30a7\u30f3\u30bb\u30eb<\/td><td>CAR-T<\/td><td>CD19<\/td><td>\u30a2\u30c0\u30eb\u30c8B-ALL<\/td><td>\u98df\u54c1\u533b\u85ac\u54c1\u5c40<\/td><td>2024<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Nebenwirkungen_%E2%80%93_Was_alle_Therapien_verbindet\"><\/span>\u526f\u4f5c\u7528-\u3059\u3079\u3066\u306e\u7642\u6cd5\u306b\u5171\u901a\u3059\u308b\u3082\u306e<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u6700\u3082\u91cd\u8981\u306a\u4e00\u822c\u7684\u30ea\u30b9\u30af<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30b9\u30c8\u30fc\u30e0\uff08CRS\uff09<\/strong><br>CAR-T\u3084TCR-T\u3067\u306f\u983b\u7e41\u306b\u8d77\u3053\u308b\u304c\u3001TIL\u3067\u306f\u307e\u308c\u3067\u3042\u308b\u3002.<br>\u30c8\u30b7\u30ea\u30ba\u30de\u30d6\u306b\u3088\u308b\u6cbb\u7642\u3002.<br>2024\u5e74\u4ee5\u964d\u3001\u3059\u3079\u3066\u306eCAR-T\u306e\u30e9\u30d9\u30eb\u306b\uff1a\u4e8c\u6b21\u6027T\u7d30\u80de\u60aa\u6027\u816b\u760d\uff08\u975e\u5e38\u306b\u307e\u308c\u3067\u3001\u6570\u5e74\u4ee5\u5185\u306b3.6 %\uff09\u306e\u67a0\u4ed8\u304d\u8b66\u544a\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>ICANS\uff08\u795e\u7d4c\u6bd2\u6027\uff09<\/strong><br>\u514d\u75ab\u7d30\u80de\u95a2\u9023\u795e\u7d4c\u6bd2\u6027\u75c7\u5019\u7fa4\uff1bCAR-T\u3067\u306f\u77e5\u3089\u308c\u3066\u3044\u308b\u304c\u3001TIL\u3067\u306f\u5c11\u306a\u3044\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7d30\u80de\u6e1b\u5c11\u75c7<\/strong><br>\u5fc5\u8981\u306a\u30ea\u30f3\u30d1\u9664\u53bb\uff08\u70b9\u6ef4\u524d\u306e\u5316\u5b66\u7642\u6cd5\uff09\u306f\u3001\u5e38\u306b\u77ed\u671f\u9593\u306e\u8840\u7403\u6570\u306e\u5909\u5316\u3092\u3082\u305f\u3089\u3059\u3002.<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wo_werden_diese_Therapien_in_Deutschland_angeboten\"><\/span>\u30c9\u30a4\u30c4\u3067\u306f\u3069\u306e\u3088\u3046\u306a\u6cbb\u7642\u304c\u884c\u308f\u308c\u3066\u3044\u308b\u306e\u3067\u3059\u304b\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">FDA\/EMA\u8a8d\u53ef\u306eCAR-T\u88fd\u54c1\u306f\u3059\u3079\u3066\u3001\u4ee5\u4e0b\u306e\u5de5\u5834\u3067\u88fd\u9020\u3055\u308c\u3066\u3044\u308b\u3002 <strong>\u5c02\u9580\u79fb\u690d\u30bb\u30f3\u30bf\u30fc<\/strong> \u30e1\u30fc\u30ab\u30fc\u304c\u8a8d\u5b9a\u3057\u3001DKMS\/EBMT\u304c\u8a8d\u5b9a\u3059\u308b\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30cf\u30f3\u30d6\u30eb\u30af\u30fb\u30a8\u30c3\u30da\u30f3\u30c9\u30eb\u30d5\u5927\u5b66\u533b\u7642\u30bb\u30f3\u30bf\u30fc\uff08UKE\uff09\uff1a<\/strong> <a href=\"https:\/\/www.uke.de\" target=\"_blank\" rel=\"noopener\">uke.de<\/a><\/li>\n\n\n\n<li><strong>\u30d9\u30eb\u30ea\u30f3\u30fb\u30b7\u30e3\u30ea\u30c6\u30a3\u5927\u5b66\uff1a<\/strong> <a href=\"https:\/\/www.charite.de\" target=\"_blank\" rel=\"noopener\">charite.de<\/a><\/li>\n\n\n\n<li><strong>LMU \u30df\u30e5\u30f3\u30d8\u30f3\u81e8\u5e8a\u30bb\u30f3\u30bf\u30fc<\/strong> <a href=\"https:\/\/www.lmu-klinikum.de\" target=\"_blank\" rel=\"noopener\">LMU-KLINIKUM.DE<\/a><\/li>\n\n\n\n<li><strong>\u30cf\u30a4\u30c7\u30eb\u30d9\u30eb\u30af\u5927\u5b66\u75c5\u9662 \/ KiTZ\uff1a<\/strong> <a href=\"https:\/\/www.kitz-heidelberg.de\" target=\"_blank\" rel=\"noopener\">kitz-heidelberg.de<\/a> <em>(PRAME\u30ea\u30b5\u30fc\u30c1\uff09<\/em><\/li>\n\n\n\n<li><strong>\u30d5\u30e9\u30f3\u30af\u30d5\u30eb\u30c8\u5927\u5b66\u75c5\u9662<\/strong> <a href=\"https:\/\/www.uniklinik-frankfurt.de\" target=\"_blank\" rel=\"noopener\">uniklinik-frankfurt.de<\/a><\/li>\n\n\n\n<li><strong>\u30d5\u30e9\u30a4\u30d6\u30eb\u30af\u5927\u5b66\u533b\u7642\u30bb\u30f3\u30bf\u30fc<\/strong> <a href=\"https:\/\/www.uniklinik-freiburg.de\" target=\"_blank\" rel=\"noopener\">uniklinik-freiburg.de<\/a><\/li>\n\n\n\n<li><strong>\u30c7\u30e5\u30c3\u30bb\u30eb\u30c9\u30eb\u30d5\u5927\u5b66\u75c5\u9662\uff0f\u30a8\u30c3\u30bb\u30f3\uff1a<\/strong> MCL\/DLBCL-CAR-T\u5c02\u9580<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u8a8d\u5b9aCAR-T\u30bb\u30f3\u30bf\u30fc\u306e\u5168\u30ea\u30b9\u30c8\uff1a<\/strong> <a href=\"https:\/\/www.ebmt.org\/registry\/center-search\" target=\"_blank\" rel=\"noopener\">EBMT\u30bb\u30f3\u30bf\u30fc\u691c\u7d22<\/a><\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Ausblick_Was_kommt_als_nachstes\"><\/span>\u5c55\u671b\uff1a\u6b21\u306e\u5c55\u671b\u306f\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u627f\u8a8d\u3055\u308c\u305f\u514d\u75ab\u7d30\u80de\u6cbb\u7642\u306e\u6b21\u306e\u6ce2\u306f\u30012026\u5e74\u304b\u30892028\u5e74\u306b\u304b\u3051\u3066\u5230\u6765\u3059\u308b\u3068\u4e88\u60f3\u3055\u308c\u308b\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>IMA203 \/ Anzu-cel\uff08PRAME-TCR\uff09\uff1a<\/strong> \u7b2c3\u76f8SUPRAME\u8a66\u9a13\u304c\u9032\u884c\u4e2d <em>\u30e1\u30e9\u30ce\u30fc\u30de\u306b\u5bfe\u3059\u308b\u627f\u8a8d\u306e\u53ef\u80fd\u6027 2027\/2028<\/em><\/li>\n\n\n\n<li><strong>\u30ea\u30d5\u30a3\u30ea\u30e5\u30fc\u30bb\u30eb\uff0b\u30da\u30e0\u30d6\u30ed\u30ea\u30ba\u30de\u30d6\uff08\u30d5\u30a7\u30fc\u30ba3\uff09\uff1a<\/strong> \u30d5\u30a1\u30fc\u30b9\u30c8\u30e9\u30a4\u30f3\u8a66\u9a13 NCT05727904 <em>\u30e1\u30e9\u30ce\u30fc\u30de\u306b\u5bfe\u3059\u308b\u30d5\u30a1\u30fc\u30b9\u30c8\u30e9\u30a4\u30f3\u627f\u8a8d\u306e\u53ef\u80fd\u6027<\/em><\/li>\n\n\n\n<li><strong>\u30d6\u30ec\u30cd\u30bf\u30d5\u30b9\u30d7\uff08PRISM-MEL-301\uff09\uff1a<\/strong> \u30d5\u30a7\u30fc\u30ba3\u8a66\u9a13 PRAME\u00d7CD3-\u4e8c\u91cd\u7279\u7570\u6027\u8a66\u9a13 <em>2027\u5e74\u8a8d\u53ef\u306e\u53ef\u80fd\u6027<\/em><\/li>\n\n\n\n<li><strong>\u81ea\u5df1\u514d\u75ab\u75be\u60a3\uff08SLE\u3001MS\uff09\u306b\u5bfe\u3059\u308bCAR-T\uff1a<\/strong> \u30d5\u30a7\u30fc\u30ba2\u8a66\u9a13\u304c\u9032\u884c\u4e2d\u3001\u521d\u306e\u975e\u816b\u760d\u6027CAR-T\u88fd\u5264\u306e\u53ef\u80fd\u6027<\/li>\n\n\n\n<li><strong>KiTZ\u30cf\u30a4\u30c7\u30eb\u30d9\u30eb\u30af\u5c0f\u5150PRAME\u8a66\u9a13\uff1a<\/strong> 2026\u5e74\u8a08\u753b - \u4e16\u754c\u521d\u306e\u5b50\u3069\u3082\u5411\u3051\u30b9\u30bf\u30c7\u30a3<\/li>\n<\/ul>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h1 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"GKV-Erstattung_von_Immunzelltherapien_in_Deutschland\"><\/span>\u30c9\u30a4\u30c4\u306b\u304a\u3051\u308b\u514d\u75ab\u7d30\u80de\u6cbb\u7642\u306eSHI\u511f\u9084<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">\u30b9\u30c6\u30fc\u30bf\u30b9 02.2026<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u72b6\u6cc1\u306f\u8907\u96d1\u3067\u3001\u6cbb\u7642\u306e\u7a2e\u985e\u3084\u88fd\u54c1\u3001\u5065\u5eb7\u4fdd\u967a\u4f1a\u793e\u306b\u3088\u3063\u3066\u5927\u304d\u304f\u7570\u306a\u308b\u3002\u4f1d\u7d71\u7684\u306a\u533b\u85ac\u54c1\u306e\u3088\u3046\u306b\u3001\u5b9a\u984d\u3067\u81ea\u52d5\u7684\u306b\u6255\u3044\u623b\u3057\u304c\u884c\u308f\u308c\u308b\u3053\u3068\u306f\u306a\u3044\u3002\u305d\u306e\u4ee3\u308f\u308a\u306b\u3001\u304b\u306a\u308a\u306e\u5b98\u50da\u4e3b\u7fa9\u3092\u4f34\u3046\u591a\u6bb5\u968e\u30b7\u30b9\u30c6\u30e0\u304c\u3042\u308a\u3001\u533b\u5e2b\u3084\u8a3a\u7642\u6240\u306f\u6a5f\u80fd\u4e0d\u5168\u306b\u9665\u3063\u3066\u3044\u308b\u3068\u516c\u7136\u3068\u6279\u5224\u3057\u3066\u3044\u308b\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"CAR-T-Zelltherapien\"><\/span>CAR-T\u7d30\u80de\u7642\u6cd5<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u822c\u7684\u306b\u8fd4\u91d1\u53ef\u80fd\u3060\u304c\u3001\u8907\u96d1<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"AMNOG_NUB-Verfahren\"><\/span>AMNOG\u3068NUB\u306e\u624b\u9806<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">CAR-T\u88fd\u5264\u306f <strong>\u5148\u9032\u6cbb\u7642\u85ac\uff08ATMP\uff09<\/strong> \u306e\u5bfe\u8c61\u3068\u306a\u308b\u3002 <strong>AMNOG\u624b\u9806<\/strong> (\u533b\u85ac\u54c1\u5e02\u5834\u518d\u7de8\u6cd5\uff09\u3002\u3053\u308c\u306f\u4ee5\u4e0b\u306e\u3053\u3068\u3092\u898f\u5b9a\u3057\u3066\u3044\u308b\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Fruhe_Nutzenbewertung_durch_den_G-BA\"><\/span>G-BA\u306b\u3088\u308b\u65e9\u671f\u5229\u76ca\u67fb\u5b9a<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">2011\u5e741\u67081\u65e5\u4ee5\u964d\u3001G-BA\u306f\u3001\u65b0\u898f\u6d3b\u6027\u7269\u8cea\u3092\u542b\u3080\u3059\u3079\u3066\u306e\u65b0\u898f\u627f\u8a8d\u533b\u85ac\u54c1\u306b\u3064\u3044\u3066\u3001\u4e0a\u5e02\u76f4\u5f8c\u306b\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u8a55\u4fa1\u3092\u5b9f\u65bd\u3059\u308b\u3053\u3068\u3092\u6cd5\u5b9a\u4efb\u52d9\u3068\u3057\u3066\u3044\u308b\u3002.<br>\u65b0\u85ac\u304c\u5f93\u6765\u306e\u6a19\u6e96\u6cbb\u7642\u3088\u308a\u3082\u512a\u308c\u3066\u3044\u308b\u304b\u3069\u3046\u304b\u304c\u30c6\u30b9\u30c8\u3055\u308c\u308b\u3002 <strong>\u9069\u5207\u306a\u6bd4\u8f03\u7642\u6cd5<\/strong> - \u304c\u30a2\u30c9\u30d0\u30f3\u30c6\u30fc\u30b8\u3068\u306a\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6cd5\u7684\u6839\u62e0<\/strong> <a href=\"https:\/\/www.gesetze-im-internet.de\/sgb_5\/__35a.html\" target=\"_blank\" rel=\"noopener\">\u00a7 \u7b2c 35a \u6761 SGB V-\u533b\u85ac\u54c1\u306e\u6709\u76ca\u6027\u306e\u8a55\u4fa1\uff08\u6cd5\u7684\u6587\u8a00\uff09<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u624b\u9806\u8aac\u660e G-BA\uff1a<\/strong> <a href=\"https:\/\/www.g-ba.de\/themen\/arzneimittel\/arzneimittel-richtlinie-anlagen\/nutzenbewertung-35a\/\" target=\"_blank\" rel=\"noopener\">g-ba.de - \u7b2c35a\u6761SGB V\u306b\u57fa\u3065\u304fAMNOG\u7d66\u4ed8\u8a55\u4fa1<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u5229\u76ca\u8a55\u4fa1\u306e\u7d50\u679c\u304c\u3001GKV-Spitzenverband\u3068\u88fd\u85ac\u30e1\u30fc\u30ab\u30fc\u3068\u306e\u4fa1\u683c\u4ea4\u6e09\u306e\u51fa\u767a\u70b9\u3068\u306a\u308b\u3002.<br>\u4ed8\u52a0\u7684\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u306e\u8a55\u4fa1\u306b\u3064\u3044\u3066\u306f\u3001\u30c9\u30a4\u30c4\u533b\u85ac\u54c1\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u8a55\u4fa1\u6761\u4f8b\u304a\u3088\u3073G-BA\u624b\u7d9a\u898f\u5247\u306e\u7b2c5\u7ae0\u306b\u898f\u5b9a\u3055\u308c\u3066\u3044\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4ed8\u52a0\u7d66\u4ed8\u306e\u30ab\u30c6\u30b4\u30ea\u30fc\u306f4\u3064\u3042\u308b\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u91cd\u8981<\/strong> \u305d\u306e\u4ed6\u306e\u7279\u5178<\/li>\n\n\n\n<li><strong>\u304b\u306a\u308a<\/strong> \u305d\u306e\u4ed6\u306e\u7279\u5178<\/li>\n\n\n\n<li><strong>\u3088\u308a\u4f4e\u3044<\/strong> \u305d\u306e\u4ed6\u306e\u7279\u5178<\/li>\n\n\n\n<li><strong>\u306a\u3057<\/strong> \u8a3c\u660e\u3055\u308c\u305f\u4ed8\u52a0\u4fa1\u5024<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u539f\u6587\u3067\u306f4\u3064\u306e\u30ab\u30c6\u30b4\u30ea\u30fc\uff1a<\/strong> <a href=\"https:\/\/www.g-ba.de\/themen\/arzneimittel\/arzneimittel-richtlinie-anlagen\/nutzenbewertung-35a\/zusatznutzen\/\" target=\"_blank\" rel=\"noopener\">g-ba.de - \u4ed8\u52a0\u4fa1\u5024\u306e\u30ab\u30c6\u30b4\u30ea\u30fc<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30ab\u30c6\u30b4\u30ea\u30fc\u306e\u6cd5\u7684\u6839\u62e0<\/strong> <a href=\"https:\/\/www.gesetze-im-internet.de\/am-nutzenv\/BJNR232400010.html\" target=\"_blank\" rel=\"noopener\">AM-NutzenV\u00a75\u7b2c7\u9805-\u533b\u85ac\u54c1\u7d66\u4ed8\u67fb\u5b9a\u6761\u4f8b\uff08\u6cd5\u7684\u6587\u8a00\uff09<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5177\u4f53\u4f8b\uff1a\u30a4\u30a8\u30b9\u30ab\u30eb\u30bf\uff08CAR-T\uff09\u306eG-BA\u6cd5\uff1a<\/strong> <a href=\"https:\/\/www.g-ba.de\/bewertungsverfahren\/nutzenbewertung\/406\/\" target=\"_blank\" rel=\"noopener\">g-ba.de - \u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u30fb\u30a2\u30bb\u30b9\u30e1\u30f3\u30c8\u624b\u7d9a\u304d Axicabtagene-Ciloleucel<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u9032\u884c\u4e2d\u304a\u3088\u3073\u5b8c\u4e86\u3057\u305f\u3059\u3079\u3066\u306eG-BA\u8a55\u4fa1\u624b\u9806\uff1a<\/strong> <a href=\"https:\/\/www.g-ba.de\/bewertungsverfahren\/nutzenbewertung\/\" target=\"_blank\" rel=\"noopener\">g-ba.de - \u8a55\u4fa1\u624b\u9806\u306e\u6982\u8981<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Preisverhandlung_nach_%C2%A7_130b_SGB_V\"><\/span>SGB\u7b2c130b\u6761\u306b\u57fa\u3065\u304f\u4fa1\u683c\u4ea4\u6e09 V<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">\u65b0\u533b\u85ac\u54c1\u306e\u4ed8\u52a0\u4fa1\u5024\u306b\u95a2\u3059\u308bG-BA\u306e\u6c7a\u5b9a\u306b\u57fa\u3065\u304d\u3001GKV-Spitzenverband\u3068\u88fd\u85ac\u4f1a\u793e\u306f\u901a\u5e38\u30016\u30f6\u6708\u4ee5\u5185\u306b4\u56de\u306e\u4ea4\u6e09\u4f1a\u8b70\u3067\u3044\u308f\u3086\u308b\u511f\u9084\u984d\u3092\u4ea4\u6e09\u3059\u308b\u3002\u3053\u308c\u306f\u5e02\u8ca9\u5f8c7\u30f6\u6708\u76ee\u304b\u3089\u3001\u6cd5\u5b9a\u5065\u5eb7\u4fdd\u967a\u52a0\u5165\u8005\u3001\u6c11\u9593\u4fdd\u967a\u52a0\u5165\u8005\u3001\u81ea\u5df1\u8ca0\u62c5\u8005\u3092\u554f\u308f\u305a\u3001\u65b0\u3057\u3044\u5168\u56fd\u7684\u306a\u8abf\u5264\u4fa1\u683c\u3068\u3057\u3066\u9069\u7528\u3055\u308c\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6cd5\u7684\u6839\u62e0<\/strong> <a href=\"https:\/\/www.gesetze-im-internet.de\/sgb_5\/__130b.html\" target=\"_blank\" rel=\"noopener\">\u00a7\u7b2c 130b \u6761 SGB V-\u511f\u9084\u984d\u306b\u95a2\u3059\u308b\u5408\u610f\uff08\u6cd5\u5f8b\u306e\u6587\u8a00\uff09<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u624b\u7d9a\u304d\u8aac\u660e GKV-Spitzenverband\uff1a<\/strong> <a href=\"https:\/\/www.gkv-spitzenverband.de\/krankenversicherung\/arzneimittel\/verhandlungen_nach_amnog\/rabatt_verhandlungen_nach_amnog.jsp\" target=\"_blank\" rel=\"noopener\">gkv-spitzenverband.de - SGB V130b\u6761\u306b\u57fa\u3065\u304fAMNOG\u4ea4\u6e09<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u4ea4\u6e09\u3055\u308c\u305f\u3059\u3079\u3066\u306e\u511f\u9084\u91d1\u984d\u306e\u6982\u8981\uff08CAR-T\u88fd\u54c1\u3092\u542b\u3080\uff09\uff1a<\/strong> <a href=\"https:\/\/www.gkv-spitzenverband.de\/krankenversicherung\/arzneimittel\/verhandlungen_nach_amnog\/ebv_130b\/ebv_nach_130b.jsp\" target=\"_blank\" rel=\"noopener\">gkv-spitzenverband.de - \u5f01\u6e08\u984d\u5354\u5b9a<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"NUB-Verfahren_fur_Krankenhauser\"><\/span>\u75c5\u9662\u306eNUB\u624b\u7d9a\u304d<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">CAR-T\u7642\u6cd5\u306f\u5165\u9662\u30d9\u30fc\u30b9\u3067\u5b9f\u65bd\u3055\u308c\u308b\u305f\u3081\u3001\u30af\u30ea\u30cb\u30c3\u30af\u3082\u307e\u305f\u3001\u4ee5\u4e0b\u306e\u5bfe\u8c61\u3068\u306a\u308b\u3002 <strong>NUB\u306e\u624b\u9806<\/strong> (KHEntgG\u7b2c6\u6761(2)\u306b\u57fa\u3065\u304f\u65b0\u305f\u306a\u691c\u67fb\u30fb\u6cbb\u7642\u6cd5\uff09\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">NUB\u624b\u7d9a\u304d\u306f\u3001\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u304cG-DRG\u5b9a\u984d\u5236\u306b\u5b8c\u5168\u306b\u7d44\u307f\u8fbc\u307e\u308c\u308b\u307e\u3067\u306e\u901a\u5e383\u5e74\u9593\u306e\u671f\u9593\u3001\u3044\u308f\u3086\u308b\u300c\u30a4\u30ce\u30d9\u30fc\u30b7\u30e7\u30f3\u30fb\u30ae\u30e3\u30c3\u30d7\u300d\u3092\u57cb\u3081\u308b\u3082\u306e\u3067\u3042\u308b\u3002.<br>\u3053\u306e\u671f\u9593\u4e2d\u3001\u75c5\u9662\u306f\u3001\u75c5\u9662\u5831\u916c\u5236\u5ea6\u7814\u7a76\u6240\uff08InEK\uff09\u304c\u5be9\u67fb\u306e\u4e0a\u3001\u30b9\u30c6\u30fc\u30bf\u30b91\u3092\u4e0e\u3048\u308b\u3053\u3068\u3092\u6761\u4ef6\u306b\u3001\u5065\u5eb7\u4fdd\u967a\u57fa\u91d1\u3068\u75c5\u9662\u56fa\u6709\u306eNUB\u6599\u91d1\u3092\u4ea4\u6e09\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u75c5\u9662\u306f\u6bce\u5e7410\u670831\u65e5\u307e\u3067\u306bNUB\u7533\u8acb\u66f8\u3092InEK\u306b\u63d0\u51fa\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3002InEK\u306f\u7fcc\u5e741\u6708\u672b\u307e\u3067\u306b\u5be9\u67fb\u7d50\u679c\u3092\u516c\u8868\u3059\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3059\u3079\u3066\u306eCAR-T\u304a\u3088\u3073TCR-T\u88fd\u5264\u3092\u542b\u3080ATMP\uff08\u5148\u9032\u6cbb\u7642\u88fd\u5264\uff09\u306b\u3064\u3044\u3066\u306f\u300110\u670831\u65e5\u307e\u3067\u306b\u7533\u8acb\u66f8\u304c\u63d0\u51fa\u3055\u308c\u3066\u3044\u308b\u5834\u5408\u3092\u9664\u304d\u3001\u6bce\u5e744\u670830\u65e5\u307e\u3067\u7533\u8acb\u671f\u9650\u304c\u5ef6\u9577\u3055\u308c\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>NUB\u624b\u7d9a\u304d\u516c\u5f0f\uff08InEK\uff09\uff1a<\/strong> <a href=\"https:\/\/www.g-drg.de\/neue-untersuchungs-und-behandlungsmethoden-nub\/drg\" target=\"_blank\" rel=\"noopener\">g-drg.de - ATMP\u306eNUB\u624b\u7d9a\u304d<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>NUB\u624b\u7d9a\u304d\uff08GKV-Spitzenverband\uff09\uff1a<\/strong> <a href=\"https:\/\/www.gkv-spitzenverband.de\/krankenversicherung\/krankenhaeuser\/drg_system\/neue_untersuchungs_und_behandlungsmethoden_nub\/neue_untersuchungs_und_behandlungsmethoden_nub.jsp\" target=\"_blank\" rel=\"noopener\">gkv-spitzenverband.de - \u75c5\u9662\u306b\u304a\u3051\u308bNUB<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>ATMP\u7279\u5225\u898f\u5b9a\u306b\u3088\u308b\u8a73\u7d30\u306a\u30d7\u30ed\u30bb\u30b9\u8aac\u660e\uff1a<\/strong> <a href=\"https:\/\/reimbursement.institute\/nub-antrag\/\" target=\"_blank\" rel=\"noopener\">\u6255\u3044\u623b\u3057.institute - NUB\u7167\u4f1a\u624b\u7d9a\u304d<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>AOK\u6982\u8981 NUB 2025\uff08\u73fe\u72b6\u6570\u5024\u3042\u308a\uff09\uff1a<\/strong> <a href=\"https:\/\/www.aok.de\/gp\/krankenhaus\/verguetung-drg\/nub\" target=\"_blank\" rel=\"noopener\">aok.de\/gp - NUB\u306e\u30bd\u30de\u30c6\u30a3\u30af\u30b9<\/a><\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Die_Realitat_Einzelfallantrage_und_Burokratie\"><\/span>\u73fe\u5b9f\uff1a\u500b\u5225\u306e\u7533\u8acb\u3068\u5b98\u50da\u4e3b\u7fa9<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u8a3a\u7642\u5831\u916c\u984d\u306e\u4ea4\u6e09\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u8a3a\u7642\u6240\u3084\u60a3\u8005\u306b\u3068\u3063\u3066\u306e\u5b9f\u52d9\u306f\u3001\u6b63\u5f0f\u306a\u898f\u5b9a\u304b\u3089\u60f3\u50cf\u3055\u308c\u308b\u3088\u308a\u3082\u304b\u306a\u308a\u8907\u96d1\u3067\u3042\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u308c\u307e\u3067\u306f\u4e00\u822c\u7684\u306b\u3001\u30bb\u30f3\u30bf\u30fc\u306f\u6cd5\u5b9a\u5065\u5eb7\u4fdd\u967a\u306b\u52a0\u5165\u3059\u308b\u305f\u3081\u306b\u500b\u5225\u306b\u7533\u8acb\u66f8\u3092\u63d0\u51fa\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u304b\u3063\u305f\u3002.<br>\u6cd5\u5b9a\u5065\u5eb7\u4fdd\u967a\u306b\u52a0\u5165\u3057\u3066\u3044\u308b\u4eba\u306b\u306f\u3001\u6a19\u6e96\u5316\u3055\u308c\u305f\u81ea\u52d5\u7684\u306a\u8cbb\u7528\u8ca0\u62c5\u306f\u306a\u3044\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30bd\u30fc\u30b9<\/strong> <a href=\"https:\/\/www.krebsinformationsdienst.de\/fachkreise\/nachrichten\/detail\/update-car-t-zell-therapie\" target=\"_blank\" rel=\"noopener\">DKFZ\u304c\u3093\u60c5\u5831\u30b5\u30fc\u30d3\u30b9 - CAR-T\u6700\u65b0\u60c5\u5831\uff1a\u5358\u4e00\u306e\u7533\u8acb\u624b\u7d9a\u304d\u3068\u5272\u5f15\u5951\u7d04<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CAR-T\u88fd\u5264\u306f\u6570\u5341\u4e07\u30e6\u30fc\u30ed\u3059\u308b\u305f\u3081\u3001\u30af\u30ea\u30cb\u30c3\u30af\u306f\u6cbb\u7642\u3092\u958b\u59cb\u3059\u308b\u524d\u306b\u8cbb\u7528\u88dc\u511f\u3092\u53d7\u3051\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3002LMU Klinikum M\u00fcnchen\u306e\u4e0a\u7d1a\u533b\u5e2b\u3067\u3042\u308bVeit B\u00fccklein\u533b\u5e2b\u306f\u3001\u305d\u306e\u52b4\u529b\u306b\u3064\u3044\u3066\u3053\u3046\u8a9e\u308b\u3002\u6b63\u5f0f\u306a\u624b\u7d9a\u304d\u306f \u201e\u500b\u5225\u8cbb\u7528\u511f\u9084\u7533\u8acb\u624b\u7d9a\u304d \u201c\u3068\u547c\u3070\u308c\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30bd\u30fc\u30b9<\/strong> <a href=\"https:\/\/pharma-fakten.de\/news\/car-t-zelltherapie-zukunftsversprechen-versus-burokratiemonster\/\" target=\"_blank\" rel=\"noopener\">\u30d5\u30a1\u30fc\u30de\u30fb\u30d5\u30a1\u30af\u30c8\uff1aCAR-T\uff1a\u672a\u6765\u306e\u7d04\u675f\u3068\u5b98\u50da\u4e3b\u7fa9\u306e\u602a\u7269\uff08LMU Klinikum M\u00fcnchen\u30012024\u5e749\u6708\uff09<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">LMU Klinikum M\u00fcnchen\u306eCAR-T\u30d7\u30ed\u30b0\u30e9\u30e0\u8cac\u4efb\u8005\u3067\u3042\u308bDr. Marion Subklewe\u306f\u3001\u3053\u306e\u6279\u5224\u3092\u6b21\u306e\u3088\u3046\u306b\u8981\u7d04\u3057\u3066\u3044\u308b\u3002\u79c1\u305f\u3061\u306f\u627f\u8a8d\u3055\u308c\u305f\u88fd\u54c1\u3092\u4f7f\u3063\u3066\u3044\u307e\u3059\u3002\u306a\u305c\u627f\u8a8d\u3055\u308c\u305f\u88fd\u54c1\u306b\u3064\u3044\u3066\u6bce\u56de\u500b\u5225\u306b\u7533\u8acb\u66f8\u3092\u63d0\u51fa\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u306e\u304b\u7406\u89e3\u3067\u304d\u307e\u305b\u3093\u300d\u3002\u73fe\u5728\u306e\u3068\u3053\u308d\u3001\u511f\u9084\u30d7\u30ed\u30bb\u30b9\u306f \u201e\u9032\u6b69\u3092\u3088\u308a\u56f0\u96e3\u306b\u3059\u308b\u9053\u5177 \u201c\u3067\u3042\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30bd\u30fc\u30b9<\/strong> <a href=\"https:\/\/pharma-fakten.de\/news\/car-t-zelltherapien-optimale-versorgung-sieht-anders-aus\/\" target=\"_blank\" rel=\"noopener\">\u30d5\u30a1\u30fc\u30de\u30fb\u30d5\u30a1\u30af\u30c8\uff1aCAR-T: \u6700\u9069\u306a\u6cbb\u7642\u6cd5\u306f\u7570\u306a\u308b\uff082025\u5e744\u6708\uff09<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30b1\u30eb\u30f3\u5927\u5b66\u75c5\u9662\u5185\u79d1I\u30af\u30ea\u30cb\u30c3\u30af\u306e\u9662\u9577\u3067\u3042\u308b\u30df\u30d2\u30e3\u30a8\u30eb\u30fb\u30cf\u30ec\u30c3\u30af\u6559\u6388\u306f\u3001\u305d\u306e\u89e3\u6c7a\u7b56\u3068\u3057\u3066\u3001CAR-T\u7d30\u80de\u7642\u6cd5\u3092\u6587\u66f8\u5316\u3057\u3001\u5b9f\u8a3c\u3055\u308c\u305f\u6210\u529f\u3092\u8a3c\u660e\u3067\u304d\u308b\u5c02\u9580\u65bd\u8a2d\u306b\u4f53\u7cfb\u7684\u306b\u5272\u308a\u5f53\u3066\u3001\u3053\u308c\u3089\u306e\u65bd\u8a2d\u306b\u6cbb\u7642\u6c7a\u5b9a\u306e\u81ea\u7531\u88c1\u91cf\u6a29\u3092\u4e0e\u3048\u308b\u3053\u3068\u3092\u63d0\u6848\u3057\u3066\u3044\u308b\u3002\u201e<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30bd\u30fc\u30b9<\/strong> <a href=\"https:\/\/pharma-fakten.de\/news\/car-t-zelltherapie-woran-es-noch-fehlt\/\" target=\"_blank\" rel=\"noopener\">\u30d5\u30a1\u30fc\u30de\u30fb\u30d5\u30a1\u30af\u30c8 - CAR-T\uff1a\u307e\u3060\u8db3\u308a\u306a\u3044\u3082\u306e\uff08\u30b1\u30eb\u30f3\u5927\u5b66\u75c5\u9662\u30012025\u5e747\u6708\uff09<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5927\u5b66\u75c5\u9662\u304b\u3089\u898b\u308b\u3068\u3001\u69cb\u9020\u7684\u306a\u554f\u984c\u306e\u6838\u5fc3\u306f\u3001\u533b\u85ac\u54c1\u304c\u8a8d\u53ef\u3055\u308c\u3066\u304b\u3089\u75c5\u9662\u304c\u511f\u9084\u3092\u53d7\u3051\u308b\u6a29\u5229\u3092\u4fdd\u8a3c\u3055\u308c\u308b\u307e\u3067\u306e\u6642\u9593\u7684\u306a\u30ae\u30e3\u30c3\u30d7\u3092\u3001\u7acb\u6cd5\u5e9c\u304c\u57cb\u3081\u3066\u3044\u306a\u3044\u3053\u3068\u3067\u3042\u308b\u3002\u65b0\u3057\u3044\u7d30\u80de\u6cbb\u7642\u3084\u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u5834\u5408\u3001\u75c5\u9662\u306e\u8ca1\u52d9\u30ea\u30b9\u30af\u304c\u9ad8\u3059\u304e\u3066\u3001\u524d\u6255\u3044\u304c\u3067\u304d\u306a\u3044\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30bd\u30fc\u30b9<\/strong> <a href=\"https:\/\/www.uniklinika.de\/gesundheitspolitischethemen\/car-t-zelltherapie\/\" target=\"_blank\" rel=\"noopener\">Uniklinika.de - CAR-T\u7d30\u80de\u7642\u6cd5\uff1a\u511f\u9084\u4fdd\u8a3c\u3078\u306e\u8981\u6c42<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CAR-T\u7d30\u80de\u7642\u6cd5\u30921\u30f5\u6708\u5f85\u3064\u3068\u3001\u76f8\u5bfe\u6b7b\u4ea1\u7387\u304c6.2\uff05\u4e0a\u6607\u3059\u308b\u3002CAR-T\u7d30\u80de\u7642\u6cd5\u3078\u306e\u30a2\u30af\u30bb\u30b9\u306e\u9045\u308c\u306f\u3001\u6cbb\u7642\u306e\u6210\u529f\u306b\u76f4\u63a5\u7684\u306a\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30bd\u30fc\u30b9<\/strong> <a href=\"https:\/\/pharma-fakten.de\/news\/car-t-zelltherapien-optimale-versorgung-sieht-anders-aus\/\" target=\"_blank\" rel=\"noopener\">Pharma-Fakten \/ IQVIA Institute - CAR-T\uff1a\u6700\u9069\u306a\u6cbb\u7642\u6cd5\u306f\u7570\u306a\u308b\uff08IQVIA\u306e\u7814\u7a76\u3092\u53c2\u8003\u306b\uff09<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">160\u4ee5\u4e0a\u306e\u75c5\u9662\u304cCAR-T\u7642\u6cd5\u3092\u63d0\u4f9b\u3059\u308b\u305f\u3081\u306bNUB\u7533\u8acb\u66f8\u3092\u63d0\u51fa\u3057\u305f\u304c\u3001\u5f53\u521d\u306fNUB\u30b9\u30c6\u30fc\u30bf\u30b94\u3057\u304b\u4e0e\u3048\u3089\u308c\u3066\u3044\u306a\u304b\u3063\u305f\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30bd\u30fc\u30b9<\/strong> <a href=\"https:\/\/www.vdek.com\/magazin\/ausgaben\/2018-1112\/politik_car_t_zelltherapie.html\" target=\"_blank\" rel=\"noopener\">VDEK - \u816b\u760d\u5b66\u306b\u304a\u3051\u308b\u9769\u547d\uff1aCAR-T\u306eNUB\u30b9\u30c6\u30fc\u30bf\u30b9\u3068\u511f\u9084\u554f\u984c<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30b5\u30d6\u30af\u30eb\u30fc\u30a8\u6559\u6388\u306f\u3001\u65e5\u5e38\u7684\u306a\u75c5\u9662\u751f\u6d3b\u306e\u4e2d\u3067\u3001\u7279\u306b\u4e0d\u5408\u7406\u306a\u4f8b\u3092\u6319\u3052\u3066\u3044\u308b\u3002\u201e\u79c1\u306f\u904e\u53bb5\u5e74\u9593\u3001\u80c3\u8178\u79d1\u533b\u3092\u5fc5\u8981\u3068\u3057\u305f\u3053\u3068\u304c\u306a\u3044\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u300124\u6642\u9593\u8fd1\u304f\u306b\u80c3\u8178\u79d1\u533b\u304c\u3044\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3068\u8a00\u308f\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u201c\u3002\u201c<br>\u4e00\u5b9a\u306e\u54c1\u8cea\u3068\u69cb\u9020\u7684\u8981\u4ef6\u306f\u7406\u306b\u304b\u306a\u3063\u3066\u3044\u308b\u304c\u3001\u73fe\u5728\u306e\u3088\u3046\u306b\u624b\u306b\u8ca0\u3048\u306a\u304f\u306a\u308b\u3053\u3068\u306f\u8a31\u3055\u308c\u308b\u3079\u304d\u3067\u306f\u306a\u3044\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30bd\u30fc\u30b9<\/strong> <a href=\"https:\/\/pharma-fakten.de\/news\/car-t-zelltherapie-zukunftsversprechen-versus-burokratiemonster\/\" target=\"_blank\" rel=\"noopener\">\u30d5\u30a1\u30fc\u30de\u30fb\u30d5\u30a1\u30af\u30c8\uff1aCAR-T\uff1a\u672a\u6765\u306e\u7d04\u675f\u3068\u5b98\u50da\u4e3b\u7fa9\u306e\u602a\u7269<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30c9\u30a4\u30c4\u306b\u304a\u3051\u308b\u8a8d\u5b9aCAR-T\u30bb\u30f3\u30bf\u30fc\u306e\u6982\u8981<\/strong> (\u60a3\u8005\u304a\u3088\u3073\u7d39\u4ecb\u533b\u5e2b\u5411\u3051\uff09\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.novartis.com\/de-de\/uebersicht-behandelnder-car-t-zentren-deutschland\" target=\"_blank\" rel=\"noopener\">\u30ce\u30d0\u30eb\u30c6\u30a3\u30b9 - \u30c9\u30a4\u30c4\u306eCAR-T\u6cbb\u7642\u30bb\u30f3\u30bf\u30fc\uff08Kymriah\uff09\u306e\u6982\u8981<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.lmu-klinikum.de\/aktuelles\/pressemitteilungen\/funf-jahre-car-t-zelltherapie-am-lmu-klinikum-nbsp\/c52167393f8351f2\" target=\"_blank\" rel=\"noopener\">LMU Klinikum M\u00fcnchen - CAR-T\u306e5\u5e74\uff1a\u30d7\u30ed\u30b0\u30e9\u30e0\u3068\u30b3\u30f3\u30bf\u30af\u30c8<\/a> <\/li>\n\n\n\n<li><a href=\"https:\/\/www.dkfz.de\/de\/presse\/pressemitteilungen\/2020\/dkfz-pm-20-40-CAR-T-Zell-Therapien-erhebliche-Kostenersparnis-moeglich.php\" target=\"_blank\" rel=\"noopener\">DKFZ - CAR T\u7d30\u80de\u7642\u6cd5\uff1a\u81ea\u793e\u751f\u7523\u306b\u3088\u308b\u30b3\u30b9\u30c8\u524a\u6e1b<\/a><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Das_%E2%80%9EPay-for-Outcome%E2%80%9C-Modell\"><\/span>\u6210\u679c\u5831\u916c\u300d\u30e2\u30c7\u30eb<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"> (\u696d\u7e3e\u9023\u52d5\u6255\u3044\u623b\u3057\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u9769\u65b0\u7684\u306a\u66ab\u5b9a\u7684\u89e3\u6c7a\u7b56\u3068\u3057\u3066\u3001\u500b\u3005\u306e\u5065\u5eb7\u4fdd\u967a\u57fa\u91d1\u304c\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u5408\u610f\u306b\u9054\u3057\u305f\u3002 <strong>\u6210\u679c\u5831\u916c\u5951\u7d04<\/strong> \u3092\u9589\u3058\u305f\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30ce\u30d0\u30eb\u30c6\u30a3\u30b9\u3068GWQ\u30b5\u30fc\u30d3\u30b9\u30d7\u30e9\u30b9\u793e\u306f\u3001\u30c9\u30a4\u30c4\u3067\u521d\u3081\u3066\u3068\u306a\u308bKymriah\u306e\u6210\u679c\u5831\u916c\u30e2\u30c7\u30eb\u3092\u7de0\u7d50\u3057\u305f\uff1a<br>\u30ce\u30d0\u30eb\u30c6\u30a3\u30b9\u306f\u3001\u60a3\u8005\u304c\u6cbb\u7642\u5f8c\u5b9a\u3081\u3089\u308c\u305f\u671f\u9593\u5185\u306b\u8840\u6db2\u304c\u3093\u3067\u6b7b\u4ea1\u3057\u305f\u5834\u5408\u3001\u85ac\u5264\u8cbb\u306e\u4e00\u90e8\u3092\u6255\u3044\u623b\u3059\u3002. <br>\u30a2\u30a6\u30c8\u30ab\u30e0\u30d1\u30e9\u30e1\u30fc\u30bf\u30fc\u306f\u6cbb\u7642\u3057\u305f\u60a3\u8005\u306e\u751f\u5b58\u7387\u3067\u3042\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u30e2\u30c7\u30eb\u306f\u5148\u4f8b\u3068\u306a\u308a\u3001\u30c6\u30af\u30cb\u30ab\u30fc\u30fb\u30af\u30e9\u30f3\u30b1\u30f3\u30ab\u30c3\u30bb\u3084\u4ed6\u306e\u4ee3\u7528\u5065\u5eb7\u4fdd\u967a\u57fa\u91d1\u3082\u540c\u69d8\u306e\u5354\u5b9a\u3092\u7d50\u3093\u3067\u3044\u308b\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Welche_CAR-T-Produkte_sind_in_Deutschland_erstattungsfahig\"><\/span>\u30c9\u30a4\u30c4\u3067\u306f\u3001\u3069\u306eCAR-T\u88fd\u54c1\u304c\u4fdd\u967a\u511f\u9084\u306e\u5bfe\u8c61\u3068\u306a\u308a\u307e\u3059\u304b\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u88fd\u54c1<\/th><th>\u8868\u793a<\/th><th>GKV\u306e\u30b9\u30c6\u30fc\u30bf\u30b9<\/th><\/tr><\/thead><tbody><tr><td><strong>\u30ad\u30e0\u30ea\u30a2<\/strong> (\u30c6\u30a3\u30b5\u30b2\u30f3\u30ec\u30af\u30ea\u30e5\u30fc\u30bb\u30eb\uff09<\/td><td>\u5c0f\u5150B-ALL\u3001DLBCL\u3001FL<\/td><td>\u2705 \u8fd4\u91d1\u984d\u4ea4\u6e09\uff082019\u5e749\u6708\u4ee5\u964d\uff09<\/td><\/tr><tr><td><strong>\u30a4\u30a8\u30b9\u30ab\u30eb\u30bf<\/strong> (\u30a2\u30af\u30b7\u30ab\u30d6\u30bf\u30b8\u30a7\u30f3\u30bb\u30eb)<\/td><td>DLBCL\u3001PMBCL\u3001FL\u3001tFL<\/td><td>\u2705 \u8fd4\u91d1\u984d\u306e\u4ea4\u6e09<\/td><\/tr><tr><td><strong>\u30c6\u30ab\u30eb\u30bf\u30b9<\/strong> (\u30d6\u30ec\u30af\u30b9\u30ab\u30d6\u30bf\u30b8\u30a7\u30f3\u30bb\u30eb)<\/td><td>MCL\u3001\u6210\u4ebaB-ALL<\/td><td>EMA\u627f\u8a8d\u3001NUB\u624b\u7d9a\u304d\u4e2d\uff0f\u5b8c\u4e86<\/td><\/tr><tr><td><strong>\u30d6\u30ec\u30e4\u30f3\u30c4\u30a3<\/strong> (\u30ea\u30be\u30ab\u30d6\u30bf\u30b8\u30a7\u30f3\u30bb\u30eb)<\/td><td>DLBCL\u3001CLL\u3001FL<\/td><td>EMA\u627f\u8a8d\uff1bNUB\u624b\u9806<\/td><\/tr><tr><td><strong>\u30a2\u30d9\u30c3\u30af\u30de<\/strong> (\u30a4\u30c7\u30ab\u30d6\u30bf\u30b8\u30a7\u30f3\u30bb\u30eb)<\/td><td>\u591a\u767a\u6027\u9aa8\u9ac4\u816b<\/td><td>EMA\u627f\u8a8d\uff1bNUB\u624b\u9806<\/td><\/tr><tr><td><strong>\u30ab\u30fc\u30f4\u30a3\u30fc\u30af\u30c6\u30a3<\/strong> (\u30c1\u30eb\u30bf\u30ab\u30d6\u30bf\u30b8\u30a7\u30f3\u30bb\u30eb)<\/td><td>\u591a\u767a\u6027\u9aa8\u9ac4\u816b<\/td><td>EMA\u627f\u8a8d\uff1bNUB\u624b\u9806<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u3044\u305a\u308c\u306b\u3057\u3066\u3082\u5b9f\u7528\u7684\u306a\u524d\u63d0\u6761\u4ef6<\/strong><br>\u6cbb\u7642\u30bb\u30f3\u30bf\u30fc\u306f\u6b21\u306e\u3053\u3068\u3092\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>G-BA\u306eATMP\u54c1\u8cea\u4fdd\u8a3c\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3092\u6e80\u305f\u3059\u3053\u3068\u3002<\/li>\n\n\n\n<li>FACT\/JACIE\u8a8d\u5b9a<\/li>\n\n\n\n<li>\u305d\u3057\u3066\u3001CAR-T\u30bb\u30f3\u30bf\u30fc\u3068\u3057\u3066\u8a8d\u5b9a\u3055\u308c\u308b\u3002.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u3046\u3057\u3066\u521d\u3081\u3066\u3001NUB\u6599\u91d1\u304c\u5408\u610f\u3055\u308c\u3001\u8acb\u6c42\u3055\u308c\u308b\u3053\u3068\u306b\u306a\u308b\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Kimmtrak_Tebentafusp_%E2%80%93_Sonderfall\"><\/span>\u30ad\u30e0\u30c8\u30e9\u30c3\u30af\uff08\u30c6\u30d9\u30f3\u30bf\u30d5\u30b9\u30d7\uff09 - \u7279\u5225\u306a\u30b1\u30fc\u30b9<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u30ad\u30e0\u30c8\u30e9\u30c3\u30af\u306f\u30bb\u30eb\u88fd\u54c1\u3067\u306f\u306a\u3044\u3002 <strong>\u30d0\u30a4\u30aa\u533b\u85ac\u54c1<\/strong> \u3067\u3042\u308a\u3001\u4ed6\u306e\u6297\u304c\u3093\u5264\u3068\u540c\u69d8\u306b\u901a\u5e38\u306eAMNOG\u624b\u7d9a\u304d\u306e\u5bfe\u8c61\u3068\u306a\u308b\u3002\u3053\u306e\u85ac\u5264\u306f\u5916\u6765\u3067\u6295\u4e0e\u3055\u308c\u3001\u4e00\u822c\u7684\u306b\u901a\u5e38\u306e\u816b\u760d\u5b66\u7684\u8acb\u6c42\u7d4c\u8def\u3067\u511f\u9084\u3055\u308c\u308b\u304c\u3001\u627f\u8a8d\u3055\u308c\u305f\u9069\u5fdc\u75c7\u306b\u9650\u3089\u308c\u308b(<strong>HLA-A*02:01\u967d\u6027\u306e\u3076\u3069\u3046\u819c\u9ed2\u8272\u816b<\/strong>, \u4e00\u884c\u76ee\uff09\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"TIL-Therapie_Lifileucel_Amtagvi_%E2%80%93_In_Deutschland_derzeit_NICHT_erstattungsfahig\"><\/span>TIL\u7642\u6cd5\uff08Lifileucel\/Amtagvi\uff09 - \u73fe\u5728\u30c9\u30a4\u30c4\u3067\u306f\u4fdd\u967a\u511f\u9084\u3055\u308c\u3066\u3044\u306a\u3044\u3002<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u308c\u304c\u7c73\u56fd\u3068\u6bd4\u3079\u305f\u73fe\u5728\u306e\u6700\u3082\u91cd\u8981\u306a\u9055\u3044\u3067\u3042\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u540c\u793e <em>\u30a2\u30a4\u30aa\u30d0\u30f3\u30b9<\/em> 2025\u5e747\u670822\u65e5\u3001EMA\u3078\u306e\u8ca9\u58f2\u627f\u8a8d\u7533\u8acb\u3092\u53d6\u308a\u4e0b\u3052\u305f\u3002. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">EMA\u306f\u3001\u4e3b\u8a66\u9a13\u306b\u304a\u3051\u308b\u594f\u52b9\u7387\u306b\u61f8\u5ff5\u3092\u62b1\u3044\u3066\u304a\u308a\u3001\u307e\u305f\u5b89\u5168\u6027\u306b\u3064\u3044\u3066\u3082\u91cd\u5927\u306a\u61f8\u5ff5\u3092\u62b1\u3044\u3066\u3044\u305f\u3002.<br>\u52a0\u3048\u3066\u3001\u88fd\u9020\u696d\u8005\u306f\u5341\u5206\u306aGMP\u6587\u66f8\u3092\u6b20\u3044\u3066\u3044\u305f\u3002. <a href=\"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2025.43.16_suppl.TPS2673\" target=\"_blank\" rel=\"noreferrer noopener\">\u7c73\u56fd\u81e8\u5e8a\u816b\u760d\u5b66\u4f1a<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30a2\u30a4\u30aa\u30d0\u30f3\u30b9\u793e\u306f\u73fe\u5728\u3001\u30a2\u30e0\u30bf\u30b0\u30d3\u306eEU\u8ca9\u58f2\u627f\u8a8d\u53d6\u5f97\u306b\u5411\u3051\u3001EMA\u3068\u3068\u3082\u306b\u65b0\u305f\u306a\u6226\u7565\u3092\u7df4\u3063\u3066\u3044\u308b\u3002\u82f1\u56fd\u3067\u306f2026\u5e74\u524d\u534a\u306e\u627f\u8a8d\u304c\u898b\u8fbc\u307e\u308c\u3066\u304a\u308a\u3001\u30aa\u30fc\u30b9\u30c8\u30e9\u30ea\u30a2\u3067\u306f\u512a\u5148\u5be9\u67fb\u304c\u8a8d\u3081\u3089\u308c\u3066\u3044\u308b\u3002. <a href=\"https:\/\/www.globenewswire.com\/de\/news-release\/2025\/03\/27\/3050384\/0\/en\/Immatics-Announces-Full-Year-2024-Financial-Results-and-Business-Update.html\" target=\"_blank\" rel=\"noreferrer noopener\">\u30b0\u30ed\u30fc\u30d6\u30fb\u30cb\u30e5\u30fc\u30b9\u30ef\u30a4\u30e4\u30fc<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30c9\u30a4\u30c4\u306e\u305f\u3081\u306e\u7d50\u8ad6<\/strong> \u30ea\u30d5\u30a3\u30ea\u30e5\u30fc\u30bb\u30eb\u306f\u73fe\u5728\u3001EU\u3067\u5165\u624b\u53ef\u80fd\u3067\u3042\u308b\u3002 <strong>\u8a8d\u53ef\u3055\u308c\u3066\u304a\u3089\u305a\u3001\u6255\u3044\u623b\u3057\u4e0d\u53ef<\/strong>. .\u3053\u306e\u6cbb\u7642\u3092\u5e0c\u671b\u3059\u308b\u60a3\u8005\u306f\u3001\u73fe\u5728\u3001\u81ea\u8cbb\u3067\u3001\u3042\u308b\u3044\u306f\u81e8\u5e8a\u8a66\u9a13\u306e\u4e00\u74b0\u3068\u3057\u3066\u3001\u7c73\u56fd\u3067\u6cbb\u7642\u3092\u53d7\u3051\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"TCR-T-Therapien_Afami-cel_Tecelra_%E2%80%93_In_Europa_nicht_zugelassen\"><\/span>TCR-T\u7642\u6cd5\uff08Afami-cel \/ Tecelra\uff09 - \u6b27\u5dde\u3067\u306f\u672a\u627f\u8a8d<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u30a2\u30d5\u30a1\u30df\u30c8\u30ec\u30b9\u30b8\u30fc\u30f3\u30fb\u30aa\u30fc\u30c8\u30ed\u30a4\u30bb\u30eb\uff08\u30c6\u30bb\u30eb\u30e9\uff09\u306f\u73fe\u5728 <strong>\u7c73\u56fd\u3067\u306e\u307f\u8a8d\u53ef<\/strong> (FDA\u30012024\u5e748\u6708\uff09\u3002EMA\u7533\u8acb\u306f\u307e\u3060\u63d0\u51fa\u3055\u308c\u3066\u3044\u306a\u3044\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u305f\u3081\u3001\u30c9\u30a4\u30c4\u3067\u306f\u6b21\u306e\u3088\u3046\u306a\u63aa\u7f6e\u304c\u3068\u3089\u308c\u3066\u3044\u308b\u3002\u4fdd\u967a\u511f\u9084\u306f\u306a\u304f\u3001\u5b9a\u671f\u7684\u306a\u30a2\u30af\u30bb\u30b9\u3082\u306a\u304f\u3001\u81e8\u5e8a\u8a66\u9a13\u307e\u305f\u306f\u500b\u5225\u6cbb\u7642\u8a66\u9a13\uff08KiTZ\u30cf\u30a4\u30c7\u30eb\u30d9\u30eb\u30af\u306b\u304a\u3051\u308b\u30de\u30a4\u30ed\u306e\u30b1\u30fc\u30b9\u306e\u3088\u3046\u306b\uff09\u3092\u7d4c\u7531\u3059\u308b\u306e\u307f\u3067\u3042\u308b\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Was_tun_wenn_die_Kasse_ablehnt_Rechtliche_Moglichkeiten\"><\/span>\u4fdd\u967a\u4f1a\u793e\u306b\u65ad\u3089\u308c\u305f\u3089\u3069\u3046\u3059\u308b\uff1f\u6cd5\u7684\u9078\u629e\u80a2<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u6cd5\u5b9a\u533b\u7642\u4fdd\u967a\u8005\u304cEMA\u8a8d\u53ef\u6cbb\u7642\u306e\u8cbb\u7528\u8ca0\u62c5\u3092\u62d2\u5426\u3057\u305f\u5834\u5408\u3001\u4ee5\u4e0b\u306e\u9078\u629e\u80a2\u304c\u3042\u308b\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u7570\u8b70 (\u00a778 SGB V)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5374\u4e0b\u5f8c4\u9031\u9593\u4ee5\u5185\u306b\u66f8\u9762\u306b\u3066\u7570\u8b70\u7533\u3057\u7acb\u3066\u3092\u884c\u3046\u3002.<\/li>\n\n\n\n<li>\u30af\u30ea\u30cb\u30c3\u30af\u3068\u533b\u5e2b\u306f\u3001\u8a73\u7d30\u306a\u8a3a\u65ad\u66f8\u3092\u540c\u5c01\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3002.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u793e\u4f1a\u88c1\u5224<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u305d\u308c\u3067\u3082\u5374\u4e0b\u3055\u308c\u305f\u5834\u5408\u306f\u3001\u7ba1\u8f44\u306e\u793e\u4f1a\u88c1\u5224\u6240\u306b\u63d0\u8a34\u3059\u308b\u3002.<\/li>\n\n\n\n<li>\u547d\u306b\u304b\u304b\u308f\u308b\u75c5\u6c17\u306e\u5834\u5408\u306f <strong>\u66ab\u5b9a\u7684\u306a\u6cd5\u7684\u4fdd\u8b77<\/strong> \u3092\u7533\u8acb\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3001, <br>\u88c1\u5224\u6240\u306f\u4eee\u306b\u8cbb\u7528\u306e\u8ca0\u62c5\u3092\u547d\u3058\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u00a7\u7b2c 2 \u6761(1a) SGB V\uff08\u30cb\u30b3\u30e9\u30a6\u30b9\u6c7a\u8b70\uff09<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u751f\u547d\u3092\u8105\u304b\u3059\u75c5\u6c17\u3067\u6a19\u6e96\u7684\u306a\u6cbb\u7642\u6cd5\u304c\u306a\u3044\u5834\u5408\u3001\u88ab\u4fdd\u967a\u8005\u306f\u3001\u6cbb\u7652\u307e\u305f\u306f\u9855\u8457\u306a\u7de9\u548c\u306e\u91cd\u5927\u306a\u898b\u8fbc\u307f\u304c\u3042\u308c\u3070\u3001\u6a19\u6e96\u7684\u3067\u306a\u3044\u8a8d\u53ef\u3055\u308c\u305f\u6cbb\u7642\u6cd5\u3092\u53d7\u3051\u308b\u6a29\u5229\u304c\u3042\u308b\u3002\u3053\u308c\u306f\u3001\u500b\u5225\u6cbb\u7642\u306e\u8a66\u307f\u306a\u3069\u306e\u5834\u5408\u306e\u4e2d\u5fc3\u7684\u306a\u6cd5\u7684\u624b\u6bb5\u3067\u3042\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u91cd\u8981\u306a\u30ea\u30bd\u30fc\u30b9<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.g-ba.de\/themen\/arzneimittel\/arzneimittel-richtlinie-anlagen\/nutzenbewertung-131e\/\" target=\"_blank\" rel=\"noopener\">\u514d\u75ab\u7d30\u80de\u6cbb\u7642\u306eG-BA\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u8a55\u4fa1<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.dgho.de\/arbeitskreise\/a-g\/drg-gesundheitsoekonomie\/nub-2025\/nub-2025\" target=\"_blank\" rel=\"noopener\">DGHO NUB \u30c6\u30f3\u30d7\u30ec\u30fc\u30c8 2025<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.krebsinformationsdienst.de\/fachkreise\/nachrichten\/detail\/update-car-t-zell-therapie\" target=\"_blank\" rel=\"noopener\">DKFZ\u304c\u3093\u60c5\u5831\u30b5\u30fc\u30d3\u30b9 - CAR-T\u3068GKV<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pharma-fakten.de\/news\/car-t-zelltherapie-woran-es-noch-fehlt\/\" target=\"_blank\" rel=\"noopener\">\u88fd\u85ac\u4f1a\u793e\u306e\u4e8b\u5b9f\u5b98\u50da\u4e3b\u7fa9\u306e\u554f\u984c CAR-T<\/a><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Osterreich\"><\/span>\u30aa\u30fc\u30b9\u30c8\u30ea\u30a2<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30aa\u30fc\u30b9\u30c8\u30ea\u30a2\u3060\uff1a<\/strong> CAR-T\u7d30\u80de\u7642\u6cd5\u306f\u30012020\u5e741\u67081\u65e5\u306b\u30aa\u30fc\u30b9\u30c8\u30ea\u30a2\u306eLKF\u30b5\u30fc\u30d3\u30b9\u30ab\u30bf\u30ed\u30b0\u306b\u63b2\u8f09\u3055\u308c\u305f\uff08\u30b0\u30eb\u30fc\u30d7MEL22.30\uff1a\u300c\u6539\u5909\u7d30\u80de\u306e\u6295\u4e0e\u300d\uff09\u3002. <a href=\"https:\/\/www.clinicaltrialvanguard.com\/news\/t-knife-files-for-phase-1-trial-of-prame-t-cell-therapy\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u30af\u30ea\u30cb\u30ab\u30eb\u30c8\u30e9\u30a4\u30a2\u30eb\u30d0\u30f3\u30ac\u30fc\u30c9<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Schweiz\"><\/span>\u30b9\u30a4\u30b9<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30b9\u30a4\u30b9<\/strong> FOPH\u306e\u5c02\u9580\u5206\u91ce\u30ea\u30b9\u30c8\u306b\u63b2\u8f09\u3055\u308c\u305f\u5f8c\u3001KVG\uff08\u5065\u5eb7\u4fdd\u967a\u6cd5\uff09\u3092\u901a\u3058\u3066\u511f\u9084\u3055\u308c\u308b\u3002EMA\u627f\u8a8d\u306eCAR-T\u88fd\u5264\u306b\u3064\u3044\u3066\u306f\u3001\u539f\u5247\u3068\u3057\u3066\u53ef\u80fd\u3060\u304c\u3001\u500b\u5225\u306e\u75c7\u4f8b\u8a55\u4fa1\u3082\u5fc5\u8981\u3002.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Zusammenfassung\"><\/span>\u6982\u8981<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u30bb\u30e9\u30d4\u30fc<\/th><th>EU\u8a8d\u53ef<\/th><th>SHI \u30c9\u30a4\u30c4<\/th><\/tr><\/thead><tbody><tr><td>CAR-T\uff08Kymriah\u3001Yescarta\u3001Tecartus\u3001Breyanzi\u3001Abecma\u3001Carvykti\uff09<\/td><td>\u306f\u3044\uff08EMA\uff09<\/td><td>\u57fa\u672c\u7684\u306b\u306f\u305d\u3046\u3060\u304c\u3001\u304b\u306a\u308a\u306e\u5b98\u50da\u4e3b\u7fa9\u3092\u4f34\u3046\u500b\u5225\u306e\u30b1\u30fc\u30b9\u7533\u8acb\uff0fNUB\u3092\u7d4c\u7531\u3059\u308b\u3002<\/td><\/tr><tr><td>\u30ad\u30e0\u30c8\u30e9\u30c3\u30af\uff08\u30c6\u30d9\u30f3\u30bf\u30d5\u30b9\u30d7\uff09<\/td><td>\u306f\u3044\uff08EMA\uff09<\/td><td>\u3042\u308a\uff08AMNOG\u6cd5\u3001\u5916\u6765\u60a3\u8005\uff09<\/td><\/tr><tr><td>\u30ea\u30d5\u30a3\u30ea\u30e5\u30fc\u30bb\u30eb\uff0f\u30a2\u30e0\u30bf\u30b0\u30d3\uff08TIL\uff09<\/td><td>\u306a\u3057\uff082025\u5e747\u6708EMA\u7533\u8acb\u53d6\u308a\u4e0b\u3052\uff09<\/td><td>\u3044\u3044\u3048<\/td><\/tr><tr><td>\u30a2\u30d5\u30a1\u30df\u30bb\u30eb\uff0f\u30c6\u30bb\u30e9\uff08TCR-T\uff09<\/td><td>\u306a\u3057\uff08FDA\u306e\u307f\uff09<\/td><td>\u3044\u3044\u3048<\/td><\/tr><tr><td>PRAME-TCR\uff08IMA203\u3001\u5b9f\u9a13\u7684\uff09<\/td><td>\u306a\u3057\uff08\u30d5\u30a7\u30fc\u30ba3\uff09<\/td><td>\u3044\u3044\u3048 - \u7814\u7a76\u53c2\u52a0\u3092\u901a\u3058\u3066\u306e\u307f<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e2d\u5fc3\u7684\u306a\u653f\u6cbb\u7684\u554f\u984c\u306f\u6b8b\u3063\u3066\u3044\u308b\uff1a\u73fe\u5728\u307e\u3067\u306e\u3068\u3053\u308d\u3001\u3053\u306e\u3088\u3046\u306a\u9769\u65b0\u7684\u306a\u6cbb\u7642\u6cd5\u3092\u8fc5\u901f\u304b\u3064\u78ba\u5b9f\u306b\u30c9\u30a4\u30c4\u306e\u5236\u5ea6\u306b\u53cd\u6620\u3055\u305b\u308b\u305f\u3081\u306e\u3001\u672c\u5f53\u306b\u512a\u308c\u305f\u6cd5\u7684\u30fb\u8ca1\u653f\u7684\u67a0\u7d44\u307f\u306f\u5b58\u5728\u3057\u306a\u3044\u3002\u533b\u7642\u6280\u8853\u9769\u65b0\u306e\u30b3\u30b9\u30c8\u304c\u75c7\u4f8b\u3054\u3068\u306e\u5b9a\u984d\u5236\u306b\u6b63\u3057\u304f\u53cd\u6620\u3055\u308c\u308b\u307e\u3067\u306b\u306f\u3001\u4f55\u5e74\u3082\u304b\u304b\u308b\u3002.<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"PKV_und_Immunzelltherapie_%E2%80%93_Die_vollstandige_Rechtslage\"><\/span>PKV\u3068\u514d\u75ab\u7d30\u80de\u7642\u6cd5-\u5b8c\u5168\u306a\u6cd5\u7684\u72b6\u6cc1<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u30b9\u30c6\u30fc\u30bf\u30b9\uff1a2026\u5e742\u6708<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Das_rechtliche_Fundament_%C2%A7_192_VVG_und_MBKK_2009\"><\/span>\u6cd5\u7684\u6839\u62e0\uff1aVVG192\u6761\u304a\u3088\u3073MB\/KK2009\u6761<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u533b\u7642\u8cbb\u4fdd\u967a\u306e\u5834\u5408\u3001\u4fdd\u967a\u8005\u306f\u5408\u610f\u3057\u305f\u7bc4\u56f2\u5185\u3067\u3001\u75c5\u6c17\u3084\u4e8b\u6545\u306e\u7d50\u679c\u306b\u3088\u308b\u533b\u7642\u4e0a\u5fc5\u8981\u306a\u6cbb\u7642\u8cbb\u3092\u6255\u3044\u623b\u3059\u7fa9\u52d9\u304c\u3042\u308b\u3002\u6cbb\u7642\u8cbb\u3084\u305d\u306e\u4ed6\u306e\u7d66\u4ed8\u91d1\u304c\u3001\u63d0\u4f9b\u3055\u308c\u308b\u7d66\u4ed8\u91d1\u3068\u8457\u3057\u304f\u4e0d\u91e3\u308a\u5408\u3044\u306a\u5834\u5408\u3001\u4fdd\u967a\u8005\u306f\u7d66\u4ed8\u91d1\u3092\u652f\u6255\u3046\u7fa9\u52d9\u3092\u8ca0\u308f\u306a\u3044\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6cd5\u7684\u8868\u73fe\u00a7192 VVG\uff08\u5b8c\u5168\u7248\uff09\uff1a<\/strong> <a href=\"https:\/\/dejure.org\/gesetze\/VVG\/192.html\" target=\"_blank\" rel=\"noopener\">dejure.org - \u7b2c192\u6761 VVG \u4fdd\u967a\u4f1a\u793e\u306e\u5178\u578b\u7684\u306a\u5951\u7d04\u4e0a\u306e\u5229\u76ca<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u516c\u5f0f\u30b5\u30f3\u30d7\u30eb\u6761\u4ef6 MB\/KK 2009 (PDF, PKV-Verband)\uff1a<\/strong> <a href=\"https:\/\/www.pkv.de\/fileadmin\/user_upload\/PKV\/3_PDFs\/ABV_und_MB\/MB-KK.pdf\" target=\"_blank\" rel=\"noopener\">pkv.de - MB\/KK 2009 \u30b5\u30f3\u30d7\u30eb\u30b3\u30f3\u30c7\u30a3\u30b7\u30e7\u30f3<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6c11\u9593\u533b\u7642\u4fdd\u967a\u4f1a\u793e\u306e\u7d66\u4ed8\u7fa9\u52d9\u306f\u3001\u57fa\u672c\u7684\u306b\u500b\u3005\u306e\u30b1\u30fc\u30b9\u3067\u9078\u629e\u3055\u308c\u308b\u4fdd\u967a\u6599\u3068\u3001\u305d\u308c\u306b\u95a2\u9023\u3059\u308b\u4fdd\u967a\u6599\u6761\u4ef6\u306b\u3088\u3063\u3066\u6c7a\u5b9a\u3055\u308c\u308b\u3002VVG\u7b2c192\u6761\u7b2c1\u9805\u304a\u3088\u3073MB\/KK\u306b\u3088\u308c\u3070\u3001\u75be\u75c5\u307e\u305f\u306f\u4e8b\u6545\u306e\u7d50\u679c\u306b\u3088\u308b\u533b\u7642\u4e0a\u5fc5\u8981\u306a\u6cbb\u7642\u8cbb\u306f\u6255\u3044\u623b\u3055\u308c\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>VVG\u7b2c192\u6761\u306b\u57fa\u3065\u304fPKV\u7d66\u4ed8\u50b5\u52d9\u306e\u8aac\u660e\uff1a<\/strong> <a href=\"https:\/\/www.legal-plus.eu\/die-leistungspflicht-der-privaten-krankenversicherung-pkv-wann-und-wofuer-muss-die-pkv-zahlen\/\" target=\"_blank\" rel=\"noopener\">legal-plus.eu - PKV\u306e\u652f\u6255\u3044\u7fa9\u52d9\uff1a\u3044\u3064\u3001\u4f55\u306e\u305f\u3081\u306b\u652f\u6255\u308f\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u306e\u304b\uff1f<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Der_Schlusselbegriff_%E2%80%9EMedizinisch_notwendige_Heilbehandlung%E2%80%9C\"><\/span>\u30ad\u30fc\u30ef\u30fc\u30c9\u306f \u201e\u533b\u5b66\u7684\u306b\u5fc5\u8981\u306a\u6cbb\u7642\u201c<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u78ba\u7acb\u3055\u308c\u305f\u5224\u4f8b\u6cd5\u306b\u3088\u308c\u3070\u3001\u307e\u305fMB\/KK\u304a\u3088\u3073\u00a7192 VVG\u306e\u30e2\u30c7\u30eb\u6761\u4ef6\u306b\u5f93\u3063\u3066\u3001\u6cbb\u7642\u304c\u5ba2\u89b3\u7684\u306a\u533b\u5b66\u7684\u77e5\u898b\u304a\u3088\u3073\u77e5\u8b58\u306b\u5f93\u3063\u3066\u3001\u75be\u75c5\u3092\u8a8d\u8b58\u3057\u6cbb\u7652\u3057\u3001\u305d\u306e\u60aa\u5316\u3092\u9632\u6b62\u3057\u3001\u307e\u305f\u306f\u75c7\u72b6\u3092\u7de9\u548c\u3059\u308b\u306e\u306b\u9069\u3057\u3066\u3044\u308b\u5834\u5408\u3001\u533b\u5b66\u7684\u5fc5\u8981\u6027\u304c\u5b58\u5728\u3059\u308b\u3002\u6c7a\u5b9a\u7684\u306a\u8981\u56e0\u306f\u3001\u6cbb\u7642\u6642\u306e\u6709\u80fd\u306a\u533b\u5e2b\u306e\u610f\u898b\u306b\u304a\u3044\u3066\u3001\u305d\u306e\u63aa\u7f6e\u304c\u516c\u8a8d\u3055\u308c\u305f\u79d1\u5b66\u7684\u57fa\u6e96\u306b\u5f93\u3063\u3066\u5fc5\u8981\u3068\u601d\u308f\u308c\u308b\u304b\u3069\u3046\u304b\u3067\u3042\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6cd5\u7684\u5206\u6790\uff1a\u6c11\u9593\u533b\u7642\u4fdd\u967a\u306b\u304a\u3051\u308b\u533b\u7642\u4e0a\u306e\u5fc5\u8981\u6027\u306e\u5b9a\u7fa9\uff1a<\/strong> <a href=\"https:\/\/kanzlei-neue-kraeme.de\/erstattung-kostenintensiver-behandlungsmassnahmen-in-der-pkv\/\" target=\"_blank\" rel=\"noopener\">kanzlei-neue-kraeme.de - \u6c11\u9593\u5065\u5eb7\u4fdd\u967a\u306b\u304a\u3051\u308b\u8cbb\u7528\u96c6\u7d04\u7684\u6cbb\u7642\u63aa\u7f6e\u306e\u6255\u3044\u623b\u3057<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5f93\u6765\u306e\u533b\u5b66\u3067\u8a8d\u3081\u3089\u308c\u3066\u3044\u308b\u6cbb\u7642\u6cd5\u306b\u52a0\u3048\u3001\u6c11\u9593\u306e\u533b\u7642\u4fdd\u967a\u3067\u306f\u3001\u5b9f\u969b\u306b\u540c\u3058\u3088\u3046\u306b\u6709\u671b\u3067\u3042\u308b\u3053\u3068\u304c\u8a3c\u660e\u3055\u308c\u3066\u3044\u308b\u6cbb\u7642\u6cd5\u3001\u3042\u308b\u3044\u306f\u4ee3\u66ff\u6cbb\u7642\u6cd5\u304c\u306a\u3044\u6cbb\u7642\u6cd5\u306b\u3082\u4fdd\u967a\u304c\u9069\u7528\u3055\u308c\u308b\u3002\u307e\u305f\u3001\u65b0\u85ac\u3084\u9769\u65b0\u7684\u306a\u8a3a\u65ad\u6cd5\u3001\u5c02\u9580\u5bb6\u304c\u6709\u7528\u3068\u8003\u3048\u308b\u6cbb\u7642\u6cd5\u3082\u5bfe\u8c61\u3068\u306a\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>PKV\u5354\u4f1a\uff1a\u7d66\u4ed8\u3068\u511f\u9084\u306b\u95a2\u3059\u308b\u516c\u5f0f\u8aac\u660e\uff08\u9769\u65b0\u7684\u6cbb\u7642\u3092\u542b\u3080\uff09\uff1a<\/strong> <a href=\"https:\/\/www.pkv.de\/wissen\/private-krankenversicherung\/leistungen-und-erstattung\/\" target=\"_blank\" rel=\"noopener\">pkv.de - \u6c11\u9593\u533b\u7642\u4fdd\u967a\u306b\u304a\u3051\u308b\u7d66\u4ed8\u3068\u6255\u3044\u623b\u3057<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Das_Richtungsurteil_OLG_Frankfurt_29062022_%E2%80%93_Az_7_U_14021\"><\/span>\u753b\u671f\u7684\u306a\u5224\u6c7a\uff1a \u30d5\u30e9\u30f3\u30af\u30d5\u30eb\u30c8\u9ad8\u7b49\u5f01\u52d9\u5b98\u4e8b\u52d9\u6240\u30012022\u5e746\u670829\u65e5-\u5be9\u5224\u756a\u53f77 U 140\/21<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u308c\u304c\u3001\u30c9\u30a4\u30c4\u306b\u304a\u3051\u308b\u514d\u75ab\u7d30\u80de\u6cbb\u7642\u306e\u6c11\u9593\u533b\u7642\u4fdd\u967a\u511f\u9084\u306e\u91cd\u8981\u306a\u5224\u65ad\u6750\u6599\u3068\u306a\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u4e8b\u5b9f\u95a2\u4fc2<\/strong><br>\u3042\u308b\u60a3\u8005\u304c\u624b\u8853\u4e0d\u53ef\u80fd\u306a\u81b5\u81d3\u816b\u760d\u3068\u8a3a\u65ad\u3055\u308c\u305f\u3002\u5316\u5b66\u7642\u6cd5\u304c\u5931\u6557\u3057\u305f\u5f8c\u3001\u5f7c\u306f\u6210\u529f\u306e\u4e88\u5f8c\u304c\u4f4e\u3044\u6a19\u6e96\u7684\u306a\u7de9\u548c\u7642\u6cd5\u3092\u65ad\u5ff5\u3057\u3001\u4ee3\u308f\u308a\u306b\u6a39\u72b6\u7d30\u80de\u7642\u6cd5\u3092\u9078\u629e\u3057\u305f\u3002\u5f7c\u306f\u305d\u306e\u8cbb\u7528\u3092\u6c11\u9593\u306e\u5065\u5eb7\u4fdd\u967a\u4f1a\u793e\u306b\u8acb\u6c42\u3057\u3088\u3046\u3068\u3057\u305f\u304c\u3001\u4fdd\u967a\u4f1a\u793e\u306f\u5168\u984d\u652f\u6255\u3044\u3092\u62d2\u5426\u3057\u305f\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5224\u5b9a<\/strong><br>\u6a39\u72b6\u7d30\u80de\u7642\u6cd5\u306f\u3001\u6c11\u9593\u533b\u7642\u4fdd\u967a\u4f1a\u793e\u306e\u533b\u7642\u8cbb\u898f\u5b9a\uff08MB\/KK 2009\uff09\u306b\u3044\u3046\u533b\u7642\u884c\u70ba\u3067\u3042\u308b\u3002\u751f\u547d\u3092\u7834\u58ca\u3059\u308b\u4e0d\u6cbb\u306e\u816b\u760d\u306b\u7f79\u60a3\u3057\u3066\u3044\u308b\u88ab\u4fdd\u967a\u8005\u304c\u3001\u5f93\u6765\u306e\u7b2c\u4e00\u9078\u629e\u7642\u6cd5\u3067\u601d\u3046\u3088\u3046\u306a\u6cbb\u7642\u52b9\u679c\u304c\u5f97\u3089\u308c\u306a\u304b\u3063\u305f\u5834\u5408\u3001\u88ab\u4fdd\u967a\u8005\u306f\u6709\u52b9\u6027\u306e\u4e88\u5f8c\u304c\u3055\u3089\u306b\u4f4e\u3044\u7b2c\u4e8c\u9078\u629e\u7642\u6cd5\u3092\u7d39\u4ecb\u3055\u308c\u308b\u5fc5\u8981\u306f\u306a\u3044\u3002\u305d\u308c\u3069\u3053\u308d\u304b\u3001\u88ab\u4fdd\u967a\u8005\u306f\u3001\u6cbb\u7642\u306e\u6642\u70b9\u3067\u3001\u6a19\u6e96\u7684\u306a\u7de9\u548c\u7642\u6cd5\u4ee5\u4e0a\u306e\u52b9\u679c\u304c\u5f97\u3089\u308c\u308b\u898b\u8fbc\u307f\u304c\u307e\u3063\u305f\u304f\u306a\u3044\u308f\u3051\u3067\u306f\u306a\u3044\u5834\u5408\u3001\u79d1\u5b66\u7684\u306b\u6839\u62e0\u306e\u3042\u308b\u65b0\u3057\u3044\u4ee3\u66ff\u7642\u6cd5\u306e\u8cbb\u7528\u306e\u76f4\u63a5\u652f\u6255\u3044\u3092\u8981\u6c42\u3067\u304d\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5224\u6c7a\u306b\u3064\u3044\u3066\u306e\u5168\u8ad6\u8003\uff08DATEV Magazin\uff09\uff1a<\/strong> <a href=\"https:\/\/www.datev-magazin.de\/nachrichten-steuern-recht\/recht\/private-krankenversicherung-muss-bei-inoperablem-tumor-nach-gescheiterter-chemotherapie-kosten-einer-alternativtherapie-mit-dendritischen-zellen-tragen-81762\" target=\"_blank\" rel=\"noopener\">datev-magazin.de - OLG\u30d5\u30e9\u30f3\u30af\u30d5\u30eb\u30c8\uff1aPKV\u306f\u6a39\u72b6\u7d30\u80de\u6cbb\u7642\u306e\u8cbb\u7528\u3092\u8ca0\u62c5\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6cd5\u7684\u52b9\u529b\u306e\u78ba\u8a8d\u3092\u4f34\u3046\u5224\u6c7a\u306e\u898b\u76f4\u3057\uff082023\u5e741\u6708\uff09\uff1a<\/strong> <a href=\"https:\/\/transkript.de\/artikel\/2023\/krankenkasse-muss-zelltherapie-zahlen\/\" target=\"_blank\" rel=\"noopener\">transkript.de - \u5065\u5eb7\u4fdd\u967a\u4f1a\u793e\u306f\u7d30\u80de\u6cbb\u7642\u8cbb\u3092\u652f\u6255\u308f\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\uff08\u6cd5\u7684\u52b9\u529b\u306e\u78ba\u8a8d\u3092\u542b\u3080\uff09<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u75c5\u9662\u306e\u305f\u3081\u306e\u5224\u5b9a\u5206\u6790\uff08IWW Verg\u00fctungsrecht\uff09\uff1a<\/strong> <a href=\"https:\/\/www.iww.de\/cb\/recht\/verguetungsrecht-schulmedizinische-behandlung-erfolglos-pkvmuss-kosten-der-alternativtherapie-tragen-f149155\" target=\"_blank\" rel=\"noopener\">iww.de - PKV\u306f\u4ee3\u66ff\u7642\u6cd5\u306e\u8cbb\u7528\u3092\u8ca0\u62c5\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u30cf\u30a6\u30d5\u30a7\uff1a\u5224\u6c7a\u3092\u7c21\u5358\u306b\u8981\u7d04\u3059\u308b\uff1a<\/strong> <a href=\"https:\/\/www.haufe.de\/recht\/weitere-rechtsgebiete\/inoperabler-tumor-uebernahme-von-alternativtherapie-durch-pkv_216_571650.html\" target=\"_blank\" rel=\"noopener\">haufe.de - \u624b\u8853\u4e0d\u80fd\u816b\u760d\uff1aPKV\u306b\u3088\u308b\u4ee3\u66ff\u7642\u6cd5<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u8a73\u7d30\u306a\u5224\u5b9a\u5206\u6790\uff08J\u00f6hnke &amp; Reichow Rechtsanw\u00e4lte\uff09\uff1a<\/strong> <a href=\"https:\/\/joehnke-reichow.de\/2024\/07\/17\/kostenerstattung-bei-einer-dendritischen-zellbehandlung-olg-frankfurt\/\" target=\"_blank\" rel=\"noopener\">joehnke-reichow.de - \u6a39\u72b6\u7d30\u80de\u6cbb\u7642\u306e\u8cbb\u7528\u511f\u9084\u3001OLG\u30d5\u30e9\u30f3\u30af\u30d5\u30eb\u30c8<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6cd5\u7684\u52b9\u529b\uff1a<\/strong> \u30d8\u30c3\u30bb\u30f3\u5dde\u9ad8\u7b49\u6cd5\u9662\u306b\u3088\u308c\u3070\u3001\u4e0a\u544a\u671f\u9650\u306f\u904e\u304e\u3066\u304a\u308a\u30012023\u5e741\u6708\u4ee5\u964d\u3001\u3053\u306e\u6c7a\u5b9a\u306f\u6cd5\u7684\u62d8\u675f\u529b\u3092\u6301\u3064\u3053\u3068\u306b\u306a\u308b\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Das_%E2%80%9Eauffallige_Missverhaltnis%E2%80%9C_nach_%C2%A7_192_Abs_2_VVG_%E2%80%93_und_warum_es_bei_CAR-T_nicht_greift\"><\/span>VVG\u7b2c192\u6761\u7b2c2\u9805\u306b\u3088\u308b\u300c\u9855\u8457\u306a\u4e0d\u91e3\u308a\u5408\u3044\u300d-CAR-T\u306b\u9069\u7528\u3055\u308c\u306a\u3044\u7406\u7531<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u9855\u8457\u306a\u4e0d\u5747\u8861\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u306e\u63d0\u793a\u30fb\u7acb\u8a3c\u8cac\u4efb\u306f\u4fdd\u967a\u8005\u306b\u3042\u308b\u3002\u63d0\u4f9b\u3055\u308c\u308b\u30b5\u30fc\u30d3\u30b9\u306e\u901a\u5e38\u306e\u4fa1\u5024\u304c\u6c7a\u5b9a\u7684\u306b\u91cd\u8981\u3067\u3042\u308a\u3001\u533b\u7642\u6700\u4f4e\u9650\u306b\u5bfe\u3059\u308b\u4fa1\u683c\u3067\u306f\u306a\u3044\u3068\u306e\u5408\u610f\u304c\u3042\u308b\u3002\u5229\u6b96\u7f6a\u306b\u95a2\u3059\u308b\u9023\u90a6\u53f8\u6cd5\u88c1\u5224\u6240\u306e\u5224\u4f8b\u3092\u9069\u7528\u3059\u308c\u3070\u3001\u5ba2\u89b3\u7684\u4fa1\u5024\u3092\u6c7a\u5b9a\u3059\u308b\u624b\u6bb5\u3068\u3057\u3066\u306f\u5e02\u5834\u6bd4\u8f03\u304c\u9069\u3057\u3066\u3044\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CAR-T\u7642\u6cd5\u306f\u4e16\u754c\u7684\u306b\u540c\u7a0b\u5ea6\u306e\u4fa1\u683c\uff0825\u4e07\uff5e60\u4e07\u30e6\u30fc\u30ed\uff09\u3067\u3042\u308b\u305f\u3081\u3001\u56fd\u969b\u5e02\u5834\u6bd4\u8f03\u306b\u3088\u3063\u3066\u300c\u9855\u8457\u306a\u4e0d\u5747\u8861\u300d\u306f\u7121\u52b9\u3068\u306a\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>VVG\u7b2c192\u6761\u7b2c2\u9805\u306b\u3088\u308b\u300c\u9855\u8457\u306a\u4e0d\u91e3\u308a\u5408\u3044\u300d\u306e\u6cd5\u7684\u5206\u6790\uff1a<\/strong> <a href=\"https:\/\/www.kunzrechtsanwaelte.de\/aktuelles\/urteile\/versicherung-und-haftung\/krankenversicherung\" target=\"_blank\" rel=\"noopener\">kunzrechtsanwaelte.de - VVG\u7b2c192\u6761\u7b2c2\u9805\u306e\u610f\u5473\u306b\u304a\u3051\u308b\u9855\u8457\u306a\u4e0d\u5747\u8861\u306b\u3064\u3044\u3066<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Das_Voranfrageverfahren_nach_%C2%A7_192_Abs_8_VVG_%E2%80%93_der_wichtigste_praktische_Schritt\"><\/span>VVG\u7b2c192\u6761(8)\u306b\u5f93\u3063\u305f\u4e88\u5099\u8abf\u67fb\u624b\u7d9a\u304d-\u6700\u3082\u91cd\u8981\u306a\u5b9f\u52d9\u30b9\u30c6\u30c3\u30d7<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e88\u60f3\u3055\u308c\u308b\u6cbb\u7642\u8cbb\u304c2,000\u30e6\u30fc\u30ed\u3092\u8d85\u3048\u308b\u3068\u4e88\u6e2c\u3055\u308c\u308b\u6642\u70b9\u3067\u3001\u88ab\u4fdd\u967a\u8005\u306fVVG\u7b2c192\u6761(8)\u306b\u5f93\u3044\u3001\u8cbb\u7528\u306e\u78ba\u7d04\u306b\u95a2\u3059\u308b\u60c5\u5831\u3092\u5f97\u308b\u6a29\u5229\u3092\u6709\u3059\u308b\u3002\u8cbb\u7528\u306e\u898b\u7a4d\u3082\u308a\u63d0\u51fa\u5f8c4\u9031\u9593\u4ee5\u5185\u306b\u3001\u4fdd\u967a\u4f1a\u793e\u306f\u8cbb\u7528\u306e\u5f15\u304d\u53d7\u3051\u3092\u627f\u8a8d\u307e\u305f\u306f\u62d2\u5426\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u671f\u9650\u5185\u306b\u60c5\u5831\u304c\u63d0\u4f9b\u3055\u308c\u306a\u3044\u5834\u5408\u3001\u4fdd\u967a\u8005\u306f\u53cd\u5bfe\u306e\u3053\u3068\u304c\u8a3c\u660e\u3055\u308c\u308b\u307e\u3067\u3001\u610f\u56f3\u3055\u308c\u305f\u533b\u7642\u51e6\u7f6e\u304c\u5fc5\u8981\u3067\u3042\u308b\u3068\u4eee\u5b9a\u3059\u308b\u3002\u3053\u306e <strong>\u5fc5\u7136\u306e\u865a\u69cb<\/strong> \u5bfe\u5fdc\u306b\u5931\u6557\u3057\u305f\u5834\u5408\u3001\u60a3\u8005\u3092\u4fdd\u8b77\u3059\u308b\u91cd\u8981\u306a\u624b\u6bb5\u3067\u3042\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6cd5\u5f8b\u7b2c192\u6761\u7b2c8\u9805VVG\uff08\u4e8b\u524d\u7167\u4f1a\u7fa9\u52d9\uff09\u306e\u6587\u8a00\uff1a<\/strong> <a href=\"https:\/\/dejure.org\/gesetze\/VVG\/192.html\" target=\"_blank\" rel=\"noopener\">dejure.org - \u7b2c192\u6761 (8) VVG<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5b9f\u65bd\u4e0a\u306e\u6ce8\u610f\uff1a\u9ad8\u984d\u306a\u6cbb\u7642\u3092\u884c\u3046\u524d\u306b\u3001PKV\u306b\u4e8b\u524d\u554f\u3044\u5408\u308f\u305b\u3092\u884c\u3046\u3053\u3068\uff1a<\/strong> <a href=\"https:\/\/www.pkv-inhalte.de\/pkv-bu-av-blog\/pkv-versichert-und-teure-behandlung-steht-bevor-wie-geht-man-richtig-vor\/\" target=\"_blank\" rel=\"noopener\">pkv-inhalte.de - PKV\u4fdd\u967a\u3068\u9ad8\u984d\u6cbb\u7642\uff1a\u6b63\u3057\u3044\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\uff1f<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>PKV\u60c5\u5831\u306e\u8aa4\u308a\u3084\u6b20\u843d\u304c\u3082\u305f\u3089\u3059\u6cd5\u7684\u5f71\u97ff\uff1a<\/strong> <a href=\"https:\/\/www.versicherungsrechtsiegen.de\/krankenhauskosten-zusatzversicherung-kostenerstattung-fuer-aufenthalt-in-privatklinik\/\" target=\"_blank\" rel=\"noopener\">versicherungsrechtsiegen.de - \u30b3\u30b9\u30c8\u30fb\u30b3\u30df\u30c3\u30c8\u30e1\u30f3\u30c8\u3068VVG\u7b2c192\u6761\u7b2c8\u9805\u306e\u5b9f\u969b<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Bei_Ablehnung_Rechtsmittel_und_Klage\"><\/span>\u4e0d\u5408\u683c\u306e\u5834\u5408\uff1a\u7570\u8b70\u7533\u3057\u7acb\u3066\u3068\u6cd5\u7684\u63aa\u7f6e<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u6255\u3044\u623b\u3057\u306e\u554f\u984c\u306f\u3001VVG\u7b2c192\u6761\u3001MB\/KK\u306e\u30e2\u30c7\u30eb\u6761\u4ef6\u3001\u304a\u3088\u3073\u500b\u3005\u306e\u6599\u91d1\u8868\u6761\u9805\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u3063\u3066\u6c7a\u5b9a\u3055\u308c\u308b\u3002\u6c7a\u5b9a\u7684\u306a\u8981\u56e0\u306f\u3001\u6cbb\u7642\u304c\u75c5\u6c17\u306e\u305f\u3081\u306b\u884c\u308f\u308c\u305f\u304b\u3069\u3046\u304b\u3001\u305d\u3057\u3066\u305d\u308c\u304c\u533b\u5b66\u7684\u306b\u5fc5\u8981\u3067\u3042\u3063\u305f\u304b\u3069\u3046\u304b\u3067\u3042\u308b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">PKV\u304c\u62d2\u5426\u3057\u305f\u5834\u5408\u3001\u4ee5\u4e0b\u306e\u9078\u629e\u80a2\u304c\u3042\u308b\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5b8c\u5168\u306a\u8a3a\u65ad\u66f8\u306b\u3088\u308b\u7570\u8b70\u7533\u3057\u7acb\u3066<\/strong> (\u533b\u5b66\u7684\u898b\u89e3\u3001\u816b\u760d\u59d4\u54e1\u4f1a\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb\u3001\u56fd\u969b\u7684\u7814\u7a76\u72b6\u6cc1\u3001\u8cbb\u7528\u898b\u7a4d\u3082\u308a\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6c11\u4e8b\u8a34\u8a1f<\/strong> (\u7dca\u6025\u306b\u6cbb\u7642\u304c\u5fc5\u8981\u306a\u5834\u5408\u306e\u4eee\u51e6\u5206\u7533\u8acb\uff08\u793e\u4f1a\u88c1\u5224\u6240\u3067\u306f\u306a\u304f\u3001\u6cd5\u5b9a\u5065\u5eb7\u4fdd\u967a\u3068\u306e\u9055\u3044\u3067\u3042\u308b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u5b8c\u5168\u30ac\u30a4\u30c9PKV\u306e\u62d2\u5426\u3001\u7570\u8b70\u7533\u3057\u7acb\u3066\u3001\u6cd5\u7684\u63aa\u7f6e\u306b\u7570\u8b70\u3092\u5531\u3048\u308b\uff1a<\/strong> <a href=\"https:\/\/kanzlei-neue-kraeme.de\/erstattung-kostenintensiver-behandlungsmassnahmen-in-der-pkv\/\" target=\"_blank\" rel=\"noopener\">kanzlei-neue-kraeme.de - \u6c11\u9593\u533b\u7642\u4fdd\u967a\u306b\u304a\u3051\u308b\u9ad8\u984d\u6cbb\u7642\u8cbb\u306e\u6255\u3044\u623b\u3057<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6c11\u9593\u306e\u5065\u5eb7\u4fdd\u967a\u3068\u7d66\u4ed8\u306e\u62d2\u5426\uff1a\u4e00\u76ee\u3067\u308f\u304b\u308b\u6cd5\u7684\u63aa\u7f6e\uff1a<\/strong> <a href=\"https:\/\/kva-plus.de\/ablehnung-der-kostenuebernahme-durch-die-pkv-und-beihilfe\/\" target=\"_blank\" rel=\"noopener\">kva-plus.de - \u6c11\u9593\u5065\u5eb7\u4fdd\u967a\u306b\u3088\u308b\u8cbb\u7528\u8ca0\u62c5\u306e\u62d2\u5426\u3068\u56fd\u306e\u63f4\u52a9<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p><span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">\u8aad\u66f8\u6642\u9593<\/span> <span class=\"rt-time\"> 20<\/span> <span class=\"rt-label rt-postfix\">\u8b70\u4e8b\u9332<\/span><\/span>Das Immunsystem &#8211; was macht das? Das Immunsystem unterh\u00e4lt eine ganze Armee von Kundschaftern, K\u00e4mpfern (T-Zellen) und Helfern. Sie patrouillieren st\u00e4ndig durch den K\u00f6rper und suchen nach Eindringlingen, wie Bakterien, Viren, aber auch wild gewordene k\u00f6rpereigene Zellen &#8211; Krebszellen. Normalerweise werden solch randalierende Zellen von den W\u00e4chtern des immunsystems schnell entdeckt, abget\u00f6tet, deren \u00dcberreste abtransportiert und zersetzt. Das passiert jeden Tag ununterbrochen. Auf diese Weise werden die meisten Krebszellen vom Immunsystem daran gehindert sich auszubreiten und rechtzeitig unsch\u00e4dlich gemacht. Doch Krebszellen sind erfinderisch, wollen sie doch um jeden Preis \u00fcberleben. Also tarnen sie sich, verstecken sich wirksam vor den W\u00e4chtern des Immunsystems und breiten sich somit nahezu unbehelligt immer weiter&hellip;&nbsp;<a href=\"https:\/\/csiag.eu\/ja\/blog\/2026\/02\/19\/immunzelltherapie\/\" rel=\"bookmark\">\u7d9a\u304d\u3092\u8aad\u3080 \"<span class=\"screen-reader-text\">\u514d\u75ab\u7d30\u80de\u7642\u6cd5<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[5584,1078,354],"tags":[],"class_list":["post-12789","post","type-post","status-publish","format-standard","hentry","category-krebs","category-medizin","category-medizin-gesundheit"],"modified_by":"Achim Goerner","_links":{"self":[{"href":"https:\/\/csiag.eu\/ja\/wp-json\/wp\/v2\/posts\/12789","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csiag.eu\/ja\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csiag.eu\/ja\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csiag.eu\/ja\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csiag.eu\/ja\/wp-json\/wp\/v2\/comments?post=12789"}],"version-history":[{"count":0,"href":"https:\/\/csiag.eu\/ja\/wp-json\/wp\/v2\/posts\/12789\/revisions"}],"wp:attachment":[{"href":"https:\/\/csiag.eu\/ja\/wp-json\/wp\/v2\/media?parent=12789"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csiag.eu\/ja\/wp-json\/wp\/v2\/categories?post=12789"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csiag.eu\/ja\/wp-json\/wp\/v2\/tags?post=12789"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}