{"id":11899,"date":"2025-12-23T12:28:25","date_gmt":"2025-12-23T12:28:25","guid":{"rendered":"https:\/\/csiag.eu\/?p=11899"},"modified":"2026-01-03T17:24:37","modified_gmt":"2026-01-03T17:24:37","slug":"autoimunines-ligos-ir-eteriniu-alieju-imunomoduliacija","status":"publish","type":"post","link":"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/","title":{"rendered":"Autoimunin\u0117s ligos ir eterini\u0173 aliej\u0173 imunomoduliacija"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_83 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Turinys<\/p>\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Autoimmunitat\" >Autoimunitetas<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Immunsuppression\" >Imunosupresija<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Immunmodulation\" >Imunomoduliacija<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Studien\" >Studijos<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Atherische_Ole\" >Eteriniai aliejai<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Chemotypen_Ct\" >Chemotipai (Ct.)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Tragerol\" >Ne\u0161an\u010dioji alyva<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Wirkmechanismen\" >Veikimo mechanizmai<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#1_Von_der_Nase_ins_Gehirn\" >1. i\u0161 nosies \u012f smegenis<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#2_Durch_die_Haut_ins_Blut\" >2. per od\u0105 \u012f krauj\u0105<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#3_Auf_zellularer_Ebene\" >3. l\u0105steliniu lygmeniu<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Atherische_Ole_%E2%80%93_schalten_Entzundungs-Schalter_aus\" >Eteriniai aliejai - i\u0161junkite u\u017edegimo jungikl\u012f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#%E2%80%A6_beruhigen_ubereifrige_Immunzellen\" >... nuraminti pernelyg uolias imunines l\u0105steles.<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#%E2%80%A6_verandern_die_Balance\" >... pakeisti pusiausvyr\u0105<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#%E2%80%A6_blockieren_Entzundungsstoffe\" >... blokuoja u\u017edegim\u0105 sukelian\u010dias med\u017eiagas<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#%E2%80%A6_schutzen_vor_oxidativem_Stress\" >... apsaugoti nuo oksidacinio streso<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Atherische_Ole_%E2%80%93_im_Einzelnen\" >Eteriniai aliejai - i\u0161samiai<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Frankincense_Weihrauch\" >Smilkalai (Frankincense)<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Frankincense_Weihrauch-Ol\" >Smilkalai (smilkal\u0173 aliejus)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Frankincense_Boswellia-Saure\" >Smilkalai (bosvelio r\u016bg\u0161tis)<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Copaiba\" >Copaiba<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Oregano\" >Raudon\u0117lis<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Lavendel\" >Levand\u0173<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Eukalyptus\" >Eukaliptas<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Nelke\" >Gvazdikai<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-26\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Teebaum\" >Arbatmedis<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-27\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Thymian\" >\u010ciobreliai<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-28\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Rosmarin\" >Rosemary<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-29\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Zitrusole_Orange_Zitrone_Bergamotte\" >Citrusiniai aliejai (apelsin\u0173, citrin\u0173, bergamo\u010di\u0173)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-30\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Ol-Kombinationen_fur_verschiedene_Autoimmunerkrankungen\" >Aliej\u0173 deriniai \u012fvairioms autoimunin\u0117ms ligoms gydyti<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-31\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Multiple_Sklerose_MS\" >I\u0161s\u0117tin\u0117 skleroz\u0117 (MS)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-32\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Rheumatoide_Arthritis\" >Reumatoidinis artritas<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-33\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Morbus_Crohn_Colitis\" >Krono liga \/ kolitas<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-34\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Lupus_Systemischer_Lupus_Erythematodes\" >Lupus (sistemin\u0117 raudonoji vilklig\u0117)<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-35\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Wechselwirkungen_mit_Biologika\" >S\u0105veika su biologiniais vaistais<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-36\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Was_sind_Biologika\" >Kas yra biologiniai vaistai?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-37\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Hauptklassen_der_Biologika\" >Pagrindin\u0117s biologini\u0173 vaist\u0173 klas\u0117s<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-38\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#TNF-%CE%B1-Inhibitoren\" >TNF-\u03b1 inhibitoriai<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-39\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Interleukin-Inhibitoren\" >Interleukino inhibitoriai<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-40\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#B-Zell-Depletoren\" >B l\u0105steli\u0173 depletoriai<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-41\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#T-Zell-Kostimulationshemmer\" >T l\u0105steli\u0173 kostimuliacijos inhibitoriai<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-42\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Integrin-Antagonisten\" >Integrin\u0173 antagonistai<\/a><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-43\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Potenzielle_additive_entzundungshemmende_Effekte\" >Galimas papildomas prie\u0161u\u017edegiminis poveikis<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-44\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Immunmodulatorische_Effekte\" >Imunomoduliacinis poveikis<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-45\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Theoretische_Risiken\" >Teorin\u0117 rizika<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-46\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Verstarkte_Immunsuppression\" >Padid\u0117jusi imunosupresija<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-47\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Erhohtes_Infektionsrisiko\" >Didesn\u0117 infekcijos rizika<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-48\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Allergische_Reaktionen_und_Hautreaktionen\" >Alergin\u0117s reakcijos ir odos reakcijos<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-49\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Leberstoffwechsel_und_Arzneimittelinteraktionen\" >Kepen\u0173 metabolizmas ir vaist\u0173 s\u0105veika<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-50\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Spezifische_Uberlegungen_zu_Immunsuppressiva\" >Ypatingos pastabos d\u0117l imunosupresant\u0173<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-51\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#TNF-%CE%B1-Inhibitoren_Atherische_Ole\" >TNF-\u03b1 inhibitoriai + eteriniai aliejai<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-52\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Interleukin-Inhibitoren_Atherische_Ole\" >Interleukino inhibitoriai + eteriniai aliejai<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-53\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#B-Zell-Depletoren_Rituximab\" >B l\u0105steli\u0173 depletoriai (rituksimabas)<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-54\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Praktische_Empfehlungen\" >Praktin\u0117s rekomendacijos<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-55\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Sichere_Anwendung_bei_Biologika-Therapie\" >Saugus naudojimas biologin\u0117s terapijos metu:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-56\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Relative_Sicherheit_%E2%80%93_Empfohlene_Ole\" >Santykinis saugumas - Rekomenduojamos alyvos:<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-57\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#%E2%80%A6_zu_vermeidende_oder_nur_nach_arztlicher_Rucksprache\" >... vengti arba vartoti tik pasitarus su gydytoju:<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-58\" href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/#Fazit\" >I\u0161vada<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Skaitymo laikas<\/span> <span class=\"rt-time\"> 20<\/span> <span class=\"rt-label rt-postfix\">minut\u0117s<\/span><\/span>\n<p>Autoimunin\u0117s ligos ir imunomoduliacija yra tiesiogiai susijusios. Toliau bus paai\u0161kinta, kaip eteriniai aliejai veikia imunomoduliuojan\u010diai, ir tai bus suprantama tiek nespecialistams, tiek medikams (remiantis tyrimais).<\/p>\n\n\n\n<p>Pirma, trys terminai, kuri\u0173 reik\u0161m\u0119 reik\u0117t\u0173 paai\u0161kinti, kad b\u016bt\u0173 i\u0161vengta bet kokios galimos painiavos:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Autoimunitetas<\/li>\n\n\n\n<li>Imunosupresija<\/li>\n\n\n\n<li>Imunomoduliacija<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Autoimmunitat\"><\/span>Autoimunitetas<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Autoimunitetas - tai terminas, apib\u016bdinantis patologin\u0119 (<em>patologinis<\/em>) \u017dmogaus organizmo imuninis atsakas prie\u0161 organizmo antigenus (pvz., bakterijas, virusus), d\u0117l kurio pa\u017eeid\u017eiamos sveikos strukt\u016bros (pvz., l\u0105stel\u0117s, audiniai), o tai savo ruo\u017etu lemia autoantik\u016bn\u0173 prie\u0161 organizmo baltymus susidarym\u0105, u\u017edegim\u0105, l\u0105steli\u0173 ar audini\u0173 sunaikinim\u0105 ir organ\u0173 funkcijos sutrikim\u0105 (<em>Disfunkcija<\/em>).<br>Autoimunitetas yra autoimunin\u0117s ligos sinonimas.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Immunsuppression\"><\/span>Imunosupresija<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Imunosupresija - tai vienos arba abiej\u0173 organizmo imunini\u0173 sistem\u0173 slopinimas. <em>humoralinis<\/em> (nel\u0105steliniai k\u016bno skys\u010di\u0173 komponentai (pvz., kraujas, limfa) ir \u012fgytas k\u016bno skystis), <em>l\u0105steli\u0173<\/em> (kurias atstovauja \u201el\u0105stel\u0117s \u017eudik\u0117s\u201c, arba. <em>T l\u0105stel\u0117s<\/em> \/ -<em>Limfocitai<\/em>) imunin\u0117 sistema.<br>J\u012f gali sukelti liga, stresas, radiacijos poveikis arba medicininis gydymas.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Immunmodulation\"><\/span>Imunomoduliacija<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Imunomoduliacija - tai imunin\u0117s sistemos reguliavimo intervencija, tiek slopinanti, tiek stimuliuojanti. Tikslas - atkurti normali\u0105 reguliavimo elgsen\u0105 (pvz., slopinim\u0105 (<em>slopinamasis<\/em>), esant autoimunitetui arba skatinant (<em>skatinamasis<\/em>) d\u0117l imunodeficito.<\/p>\n\n\n\n<p>Paprastai m\u016bs\u0173 imunin\u0117 sistema saugo mus nuo patogen\u0173, pavyzd\u017eiui, virus\u0173 ir bakterij\u0173. Ta\u010diau autoimunini\u0173 lig\u0173 atveju imunin\u0117 sistema padaro klaid\u0105: ji staiga puola sveikas organizmo l\u0105steles, tarsi jos b\u016bt\u0173 prie\u0161ai.<\/p>\n\n\n\n<p>Imunin\u0117 sistema gamina per daug \u201eatakos signal\u0173\u201c (u\u017edegimo pasiuntini\u0173, pvz. <em>TNF-\u03b1, IL-6, IL-1\u03b2<\/em>). Tai palaiko u\u017edegim\u0105, net jei n\u0117ra tikro prie\u0161o.<\/p>\n\n\n\n<p><strong>Autoimunini\u0173 lig\u0173 pavyzd\u017eiai:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>I\u0161s\u0117tin\u0117 skleroz\u0117 (MS) - U\u017epuolimas <strong>Nerv\u0173 apvalkalai<\/strong><\/li>\n\n\n\n<li>Reumatoidinis artritas - u\u017epuolimas <strong>S\u0105nariai<\/strong><\/li>\n\n\n\n<li>Krono liga ir opinis kolitas - ataka prie\u0161 <strong>\u017darnynas<\/strong><\/li>\n\n\n\n<li>Ha\u0161imoto liga - i\u0161puolis prie\u0161 <strong>Skydliauk\u0117<\/strong><\/li>\n\n\n\n<li>Lupus ... - \u012evairi\u0173 <strong>Organai<\/strong> (...)<\/li>\n\n\n\n<li>1 tipo cukrinis diabetas - ataka <strong>Kasa<\/strong><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Studien\"><\/span>Studijos<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Visos i\u0161vardytos studijos para\u0161ytos angl\u0173 kalba. Po kiekvieno tyrimo nuorodos pateikiama santrauka vokie\u010di\u0173 kalba, kurioje apytiksliai ap\u017evelgiamos pagrindin\u0117s atitinkamo tyrimo i\u0161vados.<\/p>\n\n\n\n<p>Jei tyrimas pateikiamas visu tekstu, pirmenyb\u0117 teikiama \u0161iai nuorodai. Tyrimus, kurie n\u0117ra prieinami visu tekstu, paprastai galima per\u017ei\u016br\u0117ti atitinkamame leidinyje u\u017e mokest\u012f, re\u010diau - tik u\u017esiregistravus per institucij\u0105.<\/p>\n\n\n\n<p><strong>U\u017euomina<\/strong>: Kai kurias nuorodas reikia kelis kartus patikrinti \u201eA\u0161 esu \u017emogus\u201c.<\/p>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Atherische_Ole\"><\/span>Eteriniai aliejai<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Chemotypen_Ct\"><\/span>Chemotipai (Ct.)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Chemotipai naudojami augal\u0173 r\u016b\u0161i\u0173 eteriniams aliejams, kuri\u0173 pagrindin\u0117s veikliosios med\u017eiagos kiekis skiriasi d\u0117l skirting\u0173 auginimo s\u0105lyg\u0173 (pvz., dirvo\u017eemio s\u0105lyg\u0173, auk\u0161\u010dio vir\u0161 j\u016bros lygio, klimato, UV spinduliuot\u0117s, derliaus nu\u0117mimo laiko), tod\u0117l skiriasi ir gauto aliejaus poveikis, atskirti.<\/p>\n\n\n\n<p>Vienas i\u0161 pavyzd\u017ei\u0173 - \u010diobreliai: \u010ciobreliai (<em>Ct. timolis)<\/em> turi stipresn\u012f stimuliuojant\u012f, antiseptin\u012f, atsikos\u0117jim\u0105 lengvinant\u012f poveik\u012f, o \u010diobreliai (<em>Ct. linaloolis<\/em>) turi \u0161velnesn\u012f, raminant\u012f ir atpalaiduojant\u012f poveik\u012f.<\/p>\n\n\n\n<p>Atsi\u017evelgiant \u012f siekiam\u0105 poveik\u012f, labai svarbu \u017einoti ir pasirinkti chemotip\u0105.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Tragerol\"><\/span>Ne\u0161an\u010dioji alyva<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Eteriniai aliejai (EO) yra labai lakios med\u017eiagos. Kai kurie neskiesti eteriniai aliejai dirgina od\u0105. Aliejai ne\u0161ikliai idealiai tinka efektyviai neutralizuoti abi savybes, suma\u017einti lakum\u0105, praskiesti aliejus ir padidinti j\u0173 biologin\u012f prieinamum\u0105, kai jie naudojami vieti\u0161kai (ant odos) arba \u012f vid\u0173.<\/p>\n\n\n\n<p>Visi aliejai, pasi\u017eymintys od\u0105 tausojan\u010diomis savyb\u0117mis, tinka kaip vietiniam naudojimui skirti aliejai ne\u0161ikliai, pvz. <em>Argano, simondsij\u0173, migdol\u0173 ir kokos\u0173 aliejus<\/em>, visi \u0161alto spaudimo (vietiniai) valgomieji aliejai, skirti vidaus vartojimui.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wirkmechanismen\"><\/span>Veikimo mechanizmai<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>I\u0161samesn\u012f apra\u0161ym\u0105 rasite straipsnyje \u201e<a href=\"https:\/\/csiag.eu\/lt\/eteriniai-aliejai-kodel-jie-veikia\/?hilite=hatt\" target=\"_blank\" rel=\"noreferrer noopener\">Eteriniai aliejai - kod\u0117l jie veikia<\/a>?\u201c.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"1_Von_der_Nase_ins_Gehirn\"><\/span>1. <strong>Nuo nosies iki smegen\u0173<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Kai u\u017euod\u017eiamas kvapas (<em>uosl\u0117<\/em> \/ aromatinis) eterinio aliejaus kvapo molekul\u0117s tiesiogiai pasiekia smegenis. Ten (limbin\u0117je sistemoje) jos gali:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Suma\u017einti stres\u0105 (ma\u017eiau kortizolio)<\/li>\n\n\n\n<li>Pagerinti nuotaik\u0105<\/li>\n\n\n\n<li>Ramina nerv\u0173 sistem\u0105<\/li>\n\n\n\n<li>Netiesiogiai teigiamai veikia imunin\u0119 sistem\u0105<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"2_Durch_die_Haut_ins_Blut\"><\/span>2. <strong>Per od\u0105 \u012f krauj\u0105<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Ant odos (<em>aktuali<\/em>) galima taikyti ma\u017eoms molekul\u0117ms:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>patekti \u012f krauj\u0105<\/li>\n\n\n\n<li>migruoja \u012f u\u017edegimo apimtas vietas.<\/li>\n\n\n\n<li>turi tiesiogin\u012f prie\u0161u\u017edegimin\u012f poveik\u012f.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"3_Auf_zellularer_Ebene\"><\/span>3. <strong>L\u0105steli\u0173 lygmeniu<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Kai tik veikliosios med\u017eiagos patenka \u012f organizmo l\u0105steles, jos pradeda veikti sistemi\u0161kai:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Blokuoti u\u017edegiminius pasiuntinius<\/li>\n\n\n\n<li>nuraminti neteisingai nukreiptas imunines l\u0105steles.<\/li>\n\n\n\n<li>Suaktyvinti apsauginius mechanizmus<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Atherische_Ole_%E2%80%93_schalten_Entzundungs-Schalter_aus\"><\/span>Eteriniai aliejai - i\u0161junkite u\u017edegimo jungikl\u012f<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u012esivaizduokime, kad m\u016bs\u0173 l\u0105stel\u0117se yra \u201eu\u017edegimo pagrindinis jungiklis\u201c (vadinamas NF-\u03baB). Daugelis eterini\u0173 aliej\u0173 gali \u0161\u012f jungikl\u012f i\u0161jungti.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E2%80%A6_beruhigen_ubereifrige_Immunzellen\"><\/span><strong>... nuraminti pernelyg uolias imunines l\u0105steles.<\/strong> <span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>Tam tikros imunin\u0117s l\u0105stel\u0117s (<em>T l\u0105stel\u0117s, makrofagai<\/em>) yra pernelyg aktyv\u016bs autoimunini\u0173 lig\u0173 atveju. Konkre\u010diai tai rei\u0161kia, kad jie nuolat siun\u010dia pavojaus signalus, gamina per daug u\u017edegimo pasiuntini\u0173 ir puola sveikus audinius kaip pernelyg uol\u016bs sargybiniai \u0161unys, kurie taip pat loja ant \u0161eimos nari\u0173. <br>To pasekm\u0117s, pavyzd\u017eiui, nuolatinis u\u017edegimas, patinimas, skausmas ir audini\u0173 pa\u017eeidimas.<br>Eteriniai aliejai gali \u201ei\u0161jungti\u201c \u0161ias l\u0105steles taip, kaip sul\u0117tinamas per garsiai veikian\u010dio variklio veikimas. D\u0117l to l\u0105stel\u0117s reaguoja ne taip agresyviai.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E2%80%A6_verandern_die_Balance\"><\/span><strong>... pakeisti pusiausvyr\u0105<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>Imunin\u0117 sistema turi \u201eagresyvias\u201c ir \u201etaikias\u201c l\u0105steles. Agresyvios (<em>Th1, Th17<\/em>) yra tarsi puolamosios paj\u0117gos, kovojan\u010dios su \u012fsibrov\u0117liais, ta\u010diau taip pat gali reaguoti pernelyg agresyviai.<br>Taikus (<em>Th2, Treg<\/em>) yra tarsi diplomatai - jie nuramina ir reguliuoja.<br>Sergant autoimunin\u0117mis ligomis agresyvi\u0173 l\u0105steli\u0173 yra per daug. D\u0117l to kyla per didel\u0117s imunin\u0117s reakcijos, l\u0117tinis u\u017edegimas ir audini\u0173 pa\u017eeidimas.<br>Kai kurie aliejai padeda formuoti taiklesnes l\u0105steles, kurios sulaiko agresyvias l\u0105steles ir ma\u017eina u\u017edegim\u0105.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E2%80%A6_blockieren_Entzundungsstoffe\"><\/span><strong>... blokuoja u\u017edegim\u0105 sukelian\u010dias med\u017eiagas<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>U\u017edegimo metu organizmas gamina med\u017eiagas, pvz. <em>Leukotrienai<\/em> ir <em>Prostaglandinai<\/em>, cheminiai pasiuntiniai, sukeliantys skausm\u0105, patinim\u0105, paraudim\u0105 ir kar\u0161\u010diavim\u0105.<br>Sergant autoimunin\u0117mis ligomis \u0161i\u0173 med\u017eiag\u0173 nuolat gaminama daug, tod\u0117l atsiranda l\u0117tini\u0173 nusiskundim\u0173, pavyzd\u017eiui, patin\u0119, skaudantys s\u0105nariai, nuolatinis nuovargis, \u0161ilti ir paraud\u0119 audiniai.<br>Tam tikri aliejai blokuoja fermentus, kurie gamina \u0161ias u\u017edegim\u0105 sukelian\u010dias med\u017eiagas, pana\u0161iai kaip vaistai, pvz. <em>Aspirinas<\/em> arba <em>Ibuprofenas<\/em>, tik nat\u016braliu b\u016bdu ir be nepageidaujamo \u0161alutinio poveikio.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E2%80%A6_schutzen_vor_oxidativem_Stress\"><\/span><strong>... apsaugoti nuo oksidacinio streso<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>U\u017edegimo metu susidaro agresyvi\u0173 molekuli\u0173 (pvz.<em>laisvieji radikalai<\/em>), nestabilios dalel\u0117s, kurios kaip ma\u017ei \u201esviediniai\u201c atakuoja ir pa\u017eeid\u017eia sveikas l\u0105steles. \u0160i \u017eala kaupiasi, tod\u0117l l\u0105steli\u0173 membranos tampa akytos, pa\u017eeid\u017eiama DNR ir audiniai grei\u010diau sensta.<br>D\u0117l to dar labiau padid\u0117ja u\u017edegimas, i\u0161sekimas ir pagreit\u0117ja audini\u0173 irimas.<br>Daugelyje eterini\u0173 aliej\u0173 yra antioksidant\u0173, kurie neutralizuoja \u0161iuos laisvuosius radikalus, tarsi apsauginis skydas, kuris sulaiko \u201esviedinius\u201c, kol jie dar nesp\u0117jo padaryti \u017ealos.<\/p>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Atherische_Ole_%E2%80%93_im_Einzelnen\"><\/span>Eteriniai aliejai - i\u0161samiai<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Visiems eteriniams aliejams taikomi \u0161ie reikalavimai: jie turi b\u016bti gryni ir nat\u016bral\u016bs, BE joki\u0173 pried\u0173, geriausia, kad tai b\u016bt\u0173 \u012frodyta duj\u0173 chromatografijos tyrimu, atliktu nepriklausomoje nuo gamintojo laboratorijoje. NENAUDOKITE kvapi\u0173j\u0173 aliej\u0173, sintetiniu b\u016bdu pagamint\u0173, modifikuot\u0173 ar sumai\u0161yt\u0173 aliej\u0173.<\/p>\n\n\n\n<p>Taigi a <strong>Analiz\u0117<\/strong> (kaip pavyzd\u012f naudojant smilkal\u0173 aliej\u0173) yra tokie duomenys (vert\u0117s %):<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<p>alfa-pinenas<br>alfa-tujenas<br>Limonenas<br>para-cimenas<br>Sabinenas<br>Myrcenae<br>Oktilo acetatas<br>beta pinenas<br>beta-kariofilenas<br>Terpinen-4-olis<br>alfa-felandrenas<br>delta-3-karenas<br>Camphene<br>...<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<p>37.44<br>10.80<br>  9.46<br>  5.75<br>  4.09<br>  3.53<br>  3.22<br>  1.83<br>  1.81<br>  1.47<br>  1.24<br>  1.24<br>  1.20<br>...<\/p>\n<\/div>\n<\/div>\n\n\n\n<p>Svetain\u0117 <strong>Poveikis<\/strong> atskir\u0173 pagrindini\u0173 komponent\u0173:<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p>alfa-pinenas<br>alfa-tujenas<br>Limonenas<br>para-cimenas<br>Sabinenas<br>Oktilo acetatas<br>beta-kariofilenas<br>Terpinen-4-olis<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p>Stipriai prie\u0161u\u017edegiminis<br>antimikrobinis, imunomoduliuojantis<br>antioksidantas, prie\u0161u\u017edegiminis<br>analgetikas, prie\u0161u\u017edegiminis vaistas<br>antioksidantas<br>Raminantis<br><em>CB2 receptori\u0173 agonistas<\/em> (kaip Copaiba)<br>imunomoduliuojantis (kaip arbatmed\u017eio aliejuje).<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Frankincense_Weihrauch\"><\/span>Smilkalai (Frankincense)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>I\u0161 smilkal\u0173 dervos gaunami du skirtingi produktai: eterinis aliejus (jo sud\u0117tyje yra <em>Monoterpenai<\/em>) ir bosvelijos derva (sud\u0117tyje yra <em>Bosvelio r\u016bg\u0161tys<\/em>).<\/p>\n\n\n\n<p>Abi med\u017eiagos turi skirting\u0105 poveik\u012f, ta\u010diau puikiai papildo viena kit\u0105 (\u017er. toliau).<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Frankincense_Weihrauch-Ol\"><\/span>Smilkalai (smilkal\u0173 aliejus)<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>Smilkal\u0173 aliejaus poveikis autoimunitetui priklauso nuo doz\u0117s: nors <strong>ma\u017eas<\/strong> Dozavimas <strong>Normalizavimas<\/strong> prisideda prie imunin\u0117s sistemos veiklos. <strong>didelis<\/strong> Skardin\u0117s <strong>stimuliuojantis<\/strong>, kuri\u0173 reikia vengti autoimuniteto atveju! Tod\u0117l labai svarbu \u017einoti tikslias sudedam\u0105sias dalis.<\/p>\n\n\n\n<p>Remiantis pirmiau pateiktais analiz\u0117s duomenimis, smilkal\u0173 aliej\u0173 galima vartoti suaugusiesiems ir vaikams.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Reumatoidinis artritas<\/strong> - Tepimas ant pa\u017eeist\u0173 s\u0105nari\u0173<\/li>\n\n\n\n<li><strong>I\u0161s\u0117tin\u0117 skleroz\u0117 (MS)<\/strong> - Tepkite kakl\u0105, stubur\u0105 ir p\u0117das<\/li>\n\n\n\n<li><strong>Krono liga \/ kolitas<\/strong> - Masa\u017euokite pilvo srit\u012f pagal laikrod\u017eio rodykl\u0119<\/li>\n\n\n\n<li><strong>Lupus<\/strong> ... - ant s\u0105nari\u0173 ir skausming\u0173 viet\u0173 (venkite saul\u0117s spinduli\u0173)<\/li>\n<\/ul>\n\n\n\n<p><strong>aktuali<\/strong> svetain\u0117je<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>ma\u017ea doz\u0117 (bandymams) - 0,5-1 proc. praskiedus (3-6 la\u0161ai \u012f 30 ml ne\u0161iklio aliejaus),<br>naudoti net dideliuose plotuose<\/li>\n\n\n\n<li>vidutin\u0117 doz\u0117 (chron.) - 1-2 proc. praskiedus (6-12 la\u0161\u0173 \u012f 30 ml ne\u0161iklio aliejaus),<br>2-3 kartus per dien\u0105 tepkite pa\u017eeistas vietas<\/li>\n\n\n\n<li>didesn\u0117s doz\u0117s (\u016bmin\u0117s) - 2-3 proc. praskiedus (12-18 la\u0161\u0173 \u012f 30 ml ne\u0161iklio aliejaus),<br>ne ilgiau kaip 1-2 savaites (po to gr\u012f\u017etama prie vidutin\u0117s doz\u0117s) 3-4 kartus per dien\u0105<\/li>\n<\/ul>\n\n\n\n<p>taikyti.<\/p>\n\n\n\n<p><strong>Inhaliacinis<\/strong> sisteminiam poveikiui ir streso ma\u017einimui per ultragarsin\u012f purk\u0161tuv\u0105 \/ difuzori\u0173 3 ... 5 trp. \u012f vanden\u012f 30 ... 60 min. 2 ... 3 kartus per dien\u0105.<\/p>\n\n\n\n<p>Produktams, kurie <em>Bosvelio r\u016bg\u0161tis<\/em> turin\u012f <strong>AKBA<\/strong> (<em>Acetil-11-keto-\u03b2-bosvelio r\u016bg\u0161tis<\/em>) yra labai svarbus kokybei ir veiksmingumui, tod\u0117l svarbu atlikti nepriklausom\u0105 toki\u0173 produkt\u0173 partij\u0173 analiz\u0119 (taip pat \u017er. <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6836131\/\" target=\"_blank\" rel=\"noreferrer noopener\">Tyrimas<\/a> i\u0161 Ulmo universiteto nuo 10.2019 \u201e<em>Lyginamasis smilkal\u0173 maistini\u0173 med\u017eiag\u0173 tyrimas...<\/em>\u201e).<\/p>\n\n\n\n<p>Bosvelio r\u016bg\u0161tys veikia per<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Blokavimas <em>Leukotrien\u0173 gamyba<\/em><\/strong> slopindamas ferment\u0105 <em>5-Lipoksigenaz\u0117 (5-LOX)<\/em><br>Leukotrienai yra agresyv\u016bs pasiuntiniai, i\u0161siskiriantys u\u017edegimo metu.<br>Jie sukelia:<br>- Stiprus patinimas (s\u0105nari\u0173)<br>- Bronch\u0173 vamzd\u017ei\u0173 susiaur\u0117jimas (dusulys sergant astma)<br>- Padid\u0117j\u0119s gleivi\u0173 kiekis<br>- Kit\u0173 u\u017edegimini\u0173 l\u0105steli\u0173 kaupimasis<br>- L\u0117tinis audini\u0173 pa\u017eeidimas<\/li>\n\n\n\n<li><strong>Inhibicija <em>Prostaglandin\u0173 sintez\u0117<\/em><\/strong><br>Prostaglandinai yra u\u017edegimo pasiuntiniai, kurie sustiprina skausm\u0105.<\/li>\n\n\n\n<li><strong>slopinimas <em>NF-\u03baB signalizavimo kelias<\/em><\/strong><br><em>NF-\u03baB <\/em>yra \u201eu\u017edegimo pagrindinis jungiklis\u201c l\u0105stel\u0117se. Kai jis aktyvus, \u012fsijungia \u0161imtai u\u017edegim\u0105 skatinan\u010di\u0173 gen\u0173. Bosvelio r\u016bg\u0161tys \u0161\u012f pagrindin\u012f jungikl\u012f i\u0161jungia, tod\u0117l visa u\u017edegimo kaskada sustabdoma.<\/li>\n\n\n\n<li><strong>Inhibicija <em>Papildymo sistema<\/em><\/strong> kaip imunin\u0117s apsaugos dalis.<br>Sergant autoimunin\u0117mis ligomis jis klaidingai atakuoja paties organizmo l\u0105steles. Bosvelio r\u016bg\u0161tys slopina pagrindin\u012f ferment\u0105 <em>C3 konvertaz\u0117<\/em>, kuris stabdo autoimunines atakas.<\/li>\n\n\n\n<li><strong>Perdavimas <em>Kraujo ir smegen\u0173 barjeras<\/em><\/strong><br>Ypa\u010d svarbi bosvelio r\u016bg\u0161\u010di\u0173 savyb\u0117<br>- I\u0161s\u0117tin\u0117 skleroz\u0117 (CNS u\u017edegimas)<br>- Smegen\u0173 navikai su patinimu<br>- Smegen\u0173 edema po insulto<br>nes jie veikia prie\u0161<br>- Gehrino u\u017edegimas (neurou\u017edegimas)<br>- Nervini\u0173 l\u0105steli\u0173 pa\u017eeidimas (oksidacinis stresas)<br>- Nerv\u0173 degeneracija (neurodegeneracija)<\/li>\n<\/ul>\n\n\n\n<p>\u0160is poveikis \u012frodytas tyrimais:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>I\u0161s\u0117tin\u0117 skleroz\u0117 (MS)<\/strong> - 800 .. 1 200 mg\/d<br><a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fneur.2022.894880\/full\" target=\"_blank\" rel=\"noreferrer noopener\">Neurologijos ribos (2022 m.)<\/a><\/li>\n\n\n\n<li><strong>Krono liga<\/strong> - 900 .. 1 200 mg\/d<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11215357\/\" target=\"_blank\" rel=\"noreferrer noopener\">Journal of Gastroenterology (2001)<\/a><\/li>\n\n\n\n<li><strong>Opinis kolitas<\/strong> - 1.000 .. 3 600 mg\/d<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11488449\/\" target=\"_blank\" rel=\"noreferrer noopener\">Planta Medica (2001)<\/a><\/li>\n\n\n\n<li><strong>Psoriaz\u0117<\/strong> - 1.000 .. 2 400 mg\/d<br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25395868\/\" target=\"_blank\" rel=\"noreferrer noopener\">Klinikin\u0117, kosmetin\u0117 ir tiriamoji dermatologija (2010)<\/a><\/li>\n\n\n\n<li><strong>1 tipo diabetas<\/strong><br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21596544\/\" target=\"_blank\" rel=\"noreferrer noopener\">Fitomedicina (2011)<\/a><\/li>\n<\/ul>\n\n\n\n<p>Bosvelio r\u016bg\u0161\u010di\u0173 poveikis padvigub\u0117ja d\u0117l j\u0173 tirpumo riebaluose, kai jos vartojamos kartu su daug riebal\u0173 turin\u010diu maistu!<\/p>\n\n\n\n<p>Rekomenduojama AKBA doz\u0117 suaugusiam \u017emogui (70 kg) mg\/d:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>I\u0161s\u0117tin\u0117 skleroz\u0117 - 40 ... 60<\/li>\n\n\n\n<li>Krono liga - 40 ... 60<\/li>\n\n\n\n<li>Opinis kolitas - 40 ... 60<\/li>\n\n\n\n<li>Reumatoidinis artritas - 50 ... 80<\/li>\n\n\n\n<li>Lengvas osteoartritas - 20 ... 30<\/li>\n\n\n\n<li>Sunkus osteoartritas - 50 ... 80<\/li>\n\n\n\n<li>Astma - 30 ... 40<\/li>\n\n\n\n<li>Psoriaz\u0117 - 40 ... 60<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Frankincense_Boswellia-Saure\"><\/span>Smilkalai (bosvelio r\u016bg\u0161tis)<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>Pagrindin\u0117s vidin\u0117s (sistemin\u0117s) prie\u0161u\u017edegimin\u0117s bosvelio r\u016bg\u0161ties veikliosios med\u017eiagos yra \u0161ios<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>AKBA<\/strong> (<em>3-O-acetil-11-keto-\u03b2-bosvelio r\u016bg\u0161tis<\/em> - 5-LOX slopinimas)<\/li>\n\n\n\n<li><strong>KBA<\/strong> (<em>11-keto-\u03b2-bosvelio r\u016bg\u0161tis<\/em>)<\/li>\n\n\n\n<li><strong>\u03b2-BA<\/strong> (<em>beta bosvelio r\u016bg\u0161tis<\/em>)<br>- <strong>Jungiasi su TLR4 receptoriais<\/strong> (\u012f Toll pana\u0161us receptorius 4) ir blokuoja \u0161iuos<br><em>TLR4<\/em> yra pavojaus receptorius, kuris atpa\u017e\u012fsta pa\u017eeistas molekules ir aktyvuoja u\u017edegiminius genus, taip sukurdamas u\u017eburt\u0105 autoimuniteto rat\u0105.<br>- <strong>Inhibuoja TLR4\/IL-1R signalin\u012f keli\u0105<\/strong> (antiartritinis poveikis)<br>- <strong>Ma\u017eina MAPK p38\/NF-\u03baB aktyvavim\u0105<\/strong><br><em>MAPK p38<\/em> yra signalin\u0117 grandin\u0117, aktyvuojanti u\u017edegimo genus ir kremzl\u0119 ardan\u010dius fermentus (MMP), <em>COX-2<\/em>, <em>Citokinai<\/em> pagamintas; <em>NF-\u03baB<\/em> aktyvuoja 250 gen\u0173, i\u0161 kuri\u0173 kai kurie savo ruo\u017etu <em>NF-\u03baB genai<\/em> suaktyvinti. (l\u0117tinis u\u017edegimas)<br>- <strong>Inhibuoja NLRP3 inflamazom\u0105<\/strong> (l\u0117tinis u\u017edegimas)<br>- <strong>Ma\u017eina IL-6, TNF-\u03b1, COX-2<\/strong> s\u0105nari\u0173 chondrocituose<br>- Saugo kremzl\u0119 nuo irimo (osteoartrito)<br>- <strong>Inhibuoja prostaglandino E sintaz\u0119 1<\/strong> (<em>PGES-1<\/em>), o apsauginis prostaciklinas lieka nepaliestas<br>  <em>PGES-1<\/em> gamina pagrindin\u0119 u\u017edegimin\u0119 med\u017eiag\u0105, sukelian\u010di\u0105 skausm\u0105, kar\u0161\u010diavim\u0105 ir patinim\u0105. <em>PGE2<\/em><br>- <strong>Inhibuoja katepsin\u0105 G<\/strong> (<em>Serino proteaz\u0117<\/em>)<br>  Katepsinas G naikina kremzl\u0119 ir jungiam\u0105j\u012f audin\u012f (RA), kraujagysli\u0173 sieneles (vaskulitas), \u017earnyno gleivin\u0119 (IBD) ir formuoja NET (kenksmingas autoimuniteto atveju).<br>- geresnis biologinis prieinamumas vartojant per burn\u0105 <strong>100 kart\u0173 didesn\u0117 koncentracija kraujyje<\/strong> kaip AKBA<\/li>\n<\/ul>\n\n\n\n<p>AKBA ir KBA gali b\u016bti <strong>prou\u017edegiminis fermentas<\/strong> (<em>5-Lipoksigenaz\u0117<\/em>) organizme taip, kad jis <strong>turi prie\u0161u\u017edegimin\u012f poveik\u012f<\/strong>. Unikali savyb\u0117 tarp nat\u016brali\u0173 med\u017eiag\u0173!<\/p>\n\n\n\n<p>AKBA tiesiogiai neblokuoja aktyviojo centro oksidacijos ir redukcijos b\u016bdu, kaip paprastai b\u016bna su kitomis slopinan\u010diomis med\u017eiagomis, bet prisijungia 3 nm atstumu nuo centro, tiksliai tarp membran\u0105 suri\u0161an\u010dios ir kataliz\u0117s dali\u0173, ir pertvarko fermento form\u0105.<br>Tai pad\u0117s <em>LOX-5 <\/em>sukelia ma\u017eiau u\u017edegim\u0105 skatinan\u010di\u0173 <em>Leukotrienai<\/em> pozicijoje <em>5<\/em> . <em>Arachidono r\u016bg\u0161tis<\/em> bet - pozicijoje <em>12\/15<\/em> - ma\u017eiau u\u017edegim\u0105 skatinan\u010di\u0173 ir u\u017edegim\u0105 tirpdan\u010di\u0173 <em>Lipoksinai<\/em> ir <em>Resolvine<\/em> gaminti (1<em>5-LOX aktyvavimas<\/em>).<\/p>\n\n\n\n<p>\u0160ie <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7747934\/\" target=\"_blank\" rel=\"noreferrer noopener\">Tyrimas<\/a> apib\u016bdina <em>Ferment\u0173 suri\u0161imas<\/em> i\u0161 <em>AKBA<\/em>, \u0161ie <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36567268\/\" target=\"_blank\" rel=\"noreferrer noopener\">Tyrimas<\/a> 1<em>5-LOX aktyvavimas<\/em>.<\/p>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Copaiba\"><\/span>Copaiba<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><em>\u03b2-kariofilenas<\/em> prisijungia prie <em>CB2<\/em>-imunini\u0173 l\u0105steli\u0173 receptoriai, pana\u0161\u016bs \u012f kanapi\u0173, ta\u010diau be svaiginan\u010dio kanapi\u0173 komponento.<\/p>\n\n\n\n<p>Kopaiba ramina agresyvias imunines l\u0105steles, tod\u0117l suma\u017e\u0117ja u\u017edegimin\u0117s reakcijos tiek pa\u017eeistuose audiniuose, tiek galvos ir nugaros smegenyse, o tai savo ruo\u017etu rei\u0161kia, kad suma\u017e\u0117ja spaudimas d\u0117l suma\u017e\u0117jusio patinimo ir pager\u0117ja nervini\u0173 l\u0105steli\u0173 funkcijos, pavyzd\u017eiui, suma\u017e\u0117ja tirpimas ir paraly\u017eius.<\/p>\n\n\n\n<p>Sergant i\u0161s\u0117tine skleroze nervines skaidulas saugantis mielino sluoksnis, kuris d\u0117l imunin\u0117s reakcijos tapo por\u0117tas, yra atkuriamas, tod\u0117l pager\u0117ja nerv\u0173 laidumas.<\/p>\n\n\n\n<p>Smegenyse mikroglijos imunin\u0117s l\u0105stel\u0117s persijungia i\u0161 \u201epuola\u201c \u012f \u201egydo\u201c, taip pa\u0161alindamos l\u0105steli\u0173 liku\u010dius ir u\u017ekirsdamos keli\u0105 tolesniam nervini\u0173 l\u0105steli\u0173 pa\u017eeidimui.<\/p>\n\n\n\n<p>D\u0117l to taikymo sritis<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>I\u0161s\u0117tin\u0117 skleroz\u0117 (MS)<\/li>\n\n\n\n<li>Neurologin\u0117s autoimunin\u0117s ligos<\/li>\n\n\n\n<li>Neuropatinis skausmas<\/li>\n\n\n\n<li>Centrin\u0117s nerv\u0173 sistemos u\u017edegimas<\/li>\n<\/ul>\n\n\n\n<p>kurie buvo \u012frodyti \u0161iais tyrimais:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Alberti TB ir kt.<\/strong> <strong>(2017)<\/strong> - \u201e<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28368293\/\" target=\"_blank\" rel=\"noreferrer noopener\">(-)-\u03b2-kariofilenas, CB2 receptoriui selektyvus fitokanabinoidas, slopina motorin\u012f paraly\u017ei\u0173 ir neurou\u017edegim\u0105 i\u0161s\u0117tin\u0117s skleroz\u0117s sergan\u010di\u0173 \u017eiurki\u0173 modelyje<\/a>\u201c <br>Pagrindinis MS tyrimas - BCP slopino mikroglijos l\u0105steli\u0173, CD4+\/CD8+ T limfocit\u0173 ir prou\u017edegimini\u0173 citokin\u0173 poveik\u012f - Suma\u017eino akson\u0173 demielinizacij\u0105 - Moduliavo Th1\/Treg pusiausvyr\u0105 per CB2 aktyvacij\u0105<\/li>\n\n\n\n<li><strong>Askari VR ir kt. (2023)<\/strong> - \u201e<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37509022\/\" target=\"_blank\" rel=\"noreferrer noopener\">Ma\u017eos \u03b2-kariofileno doz\u0117s suma\u017eino i\u0161s\u0117tin\u0117s skleroz\u0117s autoimuninio gyv\u016bn\u0173 modelio klinikinius ir paraklinikinius parametrus<\/a>\u201e<br>Ma\u017e\u0173 dozi\u0173 tyrimas - Ma\u017eos doz\u0117s (2,5-5 mg\/kg) buvo optimalios - Imunin\u0117 sistema i\u0161 M1\/Th1\/Th17 (u\u017edegimin\u0117) persijung\u0117 \u012f M2\/Th2\/Treg (gydomoji) - Padid\u0117jo IL-10 (prie\u0161u\u017edegimin\u0117), suma\u017e\u0117jo TNF-\u03b1, IL-6, IL-17 - Labiau veik\u0117 sistemin\u0119 nei CNS imunin\u0119 sistem\u0105<\/li>\n\n\n\n<li><strong>Askari VR ir Shafiee-Nick R (2017) <\/strong>- \u201e<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28463791\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u03b2-kariofilenas gerina eksperimentinio autoimuninio encefalomielito vystym\u0105si C57BL\/6 pel\u0117ms<\/a>\u201e<br>Mechanizmo tyrimas - Apsaugojo oligodendrocitus (mielin\u0105 gaminan\u010dias l\u0105steles) nuo LPS toksi\u0161kumo - Veik\u0117 per CB2 \u2192 Nrf2\/HO-1 (ma\u017eos doz\u0117s) ir PPAR-\u03b3 (didel\u0117s doz\u0117s) - Suma\u017eino ROS, NO, TNF-\u03b1 - Skatino M2 mikroglijos fenotip\u0105 (gijim\u0105)<\/li>\n\n\n\n<li><strong>Vafa Baradaran Rahimi, Vahid Reza Askari (2022 m.) <\/strong>- \u201e<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35648433\/\" target=\"_blank\" rel=\"noreferrer noopener\">Selektyvaus antrojo tipo kanabinoidini\u0173 receptori\u0173 \u03b2-kariofileno imunomoduliacinio poveikio mechanistin\u0117 ap\u017evalga<\/a>\u201e<br>I\u0161sami vis\u0173 mechanizm\u0173 ap\u017evalga - Antioksidantas per Nrf2\/HO-1 a\u0161\u012f - Imunomoduliatorius per CB2 aktyvavim\u0105 - Inhibitorius MAPK p38 ir NF-\u03baB<\/li>\n<\/ul>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Oregano\"><\/span>Raudon\u0117lis<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Raudon\u0117lis gali b\u016bti laikomas pernelyg aktyvi\u0173 T l\u0105steli\u0173, imunin\u0117s sistemos valdymo centro, \u201estabd\u017eiu\u201c, nes jis suma\u017eina u\u017edegimo pasiuntini\u0173 gamyb\u0105 iki 70%. D\u0117l to gerokai suma\u017e\u0117ja pagrindini\u0173 IL-2 ir IFN-\u03b3 pasiuntini\u0173, kurie spartina u\u017edegim\u0105 ir pa\u017eeid\u017eia audinius.<\/p>\n\n\n\n<p>Jis taip pat sustabdo pernelyg uolias T l\u0105steles, kurios puola sveikus audinius, nes gauna klaiding\u0105 informacij\u0105, kad reikia kovoti su sveikomis audini\u0173 l\u0105stel\u0117mis.<\/p>\n\n\n\n<p>Sergant i\u0161s\u0117tine skleroze (i\u0161s\u0117tin\u0117 skleroz\u0117), jis aktyvina MBP ir OLIG2 genus, atsakingus u\u017e l\u0105steli\u0173 regeneracij\u0105, kurie yra ypa\u010d atsakingi u\u017e d\u0117l ligos sutr\u016bkin\u0117jusio mielino sluoksnio atstatym\u0105.<\/p>\n\n\n\n<p>Smegenyse jis neleid\u017eia u\u017edegimin\u0117ms l\u0105stel\u0117ms patekti \u012f smegenis ir plisti, taip nutraukdamas u\u017edegimin\u0119 kaskad\u0105 ir suma\u017eindamas neurologinius simptomus.<\/p>\n\n\n\n<p>D\u0117l to atsiranda \u0161ios taikymo sritys<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>I\u0161s\u0117tin\u0117 skleroz\u0117 (MS)<\/li>\n\n\n\n<li>Reumatoidinis artritas<\/li>\n\n\n\n<li>T l\u0105steli\u0173 sukeltos autoimunin\u0117s ligos<\/li>\n<\/ul>\n\n\n\n<p>kurie yra pagr\u012fsti \u0161iais tyrimais:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Khorsandi L ir kiti (2019)<\/strong> - \u201e<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0024320518307720?via%3Dihub\" target=\"_blank\" rel=\"noreferrer noopener\">Karvakrolis gerina eksperimentin\u012f autoimunin\u012f encefalomielit\u0105 moduliuodamas pro- ir prie\u0161u\u017edegiminius citokinus<\/a>\u201e<br>Pagrindiniai EAE tyrimai - Reik\u0161mingai suma\u017e\u0117jo klinikini\u0173 rodikli\u0173 (p&lt;0,001) - Suma\u017e\u0117jo IFN-\u03b3, IL-6, IL-17 (prou\u017edegiminiai) - Padid\u0117jo TGF-\u03b2, IL-4, IL-10 (prie\u0161u\u017edegiminiai) - Suma\u017e\u0117jo leukocit\u0173 infiltracija \u012f CNS<\/li>\n\n\n\n<li><strong>Ahmadi M ir kt. (2023)<\/strong> - <br>\u201e<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S2211034822009750\" target=\"_blank\" rel=\"noreferrer noopener\">Karvakrolio poveikis i\u0161s\u0117tin\u0117s skleroz\u0117s histologinei analizei ir i\u0161s\u0117tin\u0117s skleroz\u0117s gyv\u016bn\u0173 modelio gen\u0173 rai\u0161kai<\/a>\u201e<br>Gen\u0173 rai\u0161kos tyrimas - \u017dymiai suma\u017eino NF-\u03baB, IL-1 ir IL-17 gen\u0173 rai\u0161k\u0105 - Padidino MBP (bazinio mielino baltymo) ir OLIG2 (oligodendrocit\u0173 \u017eymens) kiek\u012f - Skatino remielinizacij\u0105 - Histologi\u0161kai nustatyta ma\u017eiau demielinizacijos ir infiltrat\u0173.<\/li>\n\n\n\n<li><strong>Fahad Khan Thareen (2024 m.)<\/strong><br>Ap\u017evalga: \u201e<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11721141\/\" target=\"_blank\" rel=\"noreferrer noopener\">Karvakrolio eterinis aliejus kaip neuroprotekcin\u0117 med\u017eiaga<\/a>\u201e<br>I\u0161sami ap\u017evalga: i\u0161analizuoti 59 tyrimai (2009-2024 m.) - Neuroprotekcinis poveikis sergantiesiems i\u0161s\u0117tine skleroze, Alzheimerio ir Parkinsono ligomis, i\u0161emija, epilepsija - Antioksidacinis, prie\u0161u\u017edegiminis ir imunomoduliacinis poveikis - Reguliuoja vidul\u0105stelin\u0119 Ca2+ homeostaz\u0119<\/li>\n<\/ul>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Lavendel\"><\/span>Levand\u0173<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Veikimo b\u016bdas priklauso nuo doz\u0117s!<\/p>\n\n\n\n<p>Levandos neutralizuoja nuolatinio streso pasekmes, tod\u0117l u\u017edegim\u0105 skatinantis <em>Kortizolis<\/em>i\u0161siskyrim\u0105, kuris ne tik dirgina imunin\u0119 sistem\u0105, bet ir sukelia pa\u016bm\u0117jimus. Jis ma\u017eina kortizolio kiek\u012f ir taip veikia prie\u0161u\u017edegimi\u0161kai.<\/p>\n\n\n\n<p>Jis skatina mieg\u0105 ir palaiko imunin\u0117s sistemos regeneracij\u0105 gilaus miego faz\u0117se: ma\u017e\u0117ja u\u017edegimas ir atstatomi audini\u0173 pa\u017eeidimai.<\/p>\n\n\n\n<p>Nerv\u0173 sistema nurimsta, suaktyv\u0117ja <em>Parasimpatin\u0117 nerv\u0173 sistema<\/em>, kuris \u012fjungia poilsio ir vir\u0161kinimo re\u017eim\u0105, skatinant\u012f gijimo procesus.<\/p>\n\n\n\n<p>Levandos taip pat blokuoja u\u017edegiminius pasiuntinius l\u0105stel\u0117se, tod\u0117l veikia prie\u0161u\u017edegimi\u0161kai,<\/p>\n\n\n\n<p>Tod\u0117l levandos tinka kaip papildoma terapija<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>visos autoimunin\u0117s ligos<\/li>\n\n\n\n<li>streso sukelti atkry\u010diai<\/li>\n\n\n\n<li>l\u0117tin\u0117s ligos<\/li>\n<\/ul>\n\n\n\n<p>tai patvirtina ir toliau pateikiami tyrimai:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Horvath G ir kiti (2021)<\/strong> - \u201e<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8611982\/\" target=\"_blank\" rel=\"noreferrer noopener\">Levand\u0173 (Lavandula angustifolia Mill.) eterinio aliejaus, paruo\u0161to skirtingomis augal\u0173 fenofaz\u0117mis, prie\u0161u\u017edegiminis poveikis THP-1 makrofagams<\/a>\u201e<br>Linalolio ir levand\u0173 aliejaus kiekis suma\u017eintas <em>IL-6, IL-8, IL-1\u03b2, TNF-\u03b1<\/em> Significant - Pana\u0161us \u012f <em>NF\u03baB inhibitoriai<\/em> - Geriausias poveikis: aliejus nuo \u017eyd\u0117jimo prad\u017eios<\/li>\n\n\n\n<li><strong>Silva GL ir kiti (2015)<\/strong> - \u201e<a href=\"https:\/\/www.scielo.br\/j\/aabc\/a\/PxSc9T7wm4fXK4KCXrvWwWy\/?lang=en\" target=\"_blank\" rel=\"noreferrer noopener\">Levand\u0173 eterinio aliejaus antioksidacinis, analgetinis ir prie\u0161u\u017edegiminis poveikis<\/a>\u201e<br>In vivo prie\u0161u\u017edegiminis poveikis - Karagenano sukeltas pleuritas: levand\u0173 aliejus suma\u017eino u\u017edegim\u0105 - Krotono aliejaus sukelta edema: poveikis pana\u0161us \u012f gydom\u0105j\u012f. <em>Deksametazonas<\/em> - Formalino testas: skausmo mal\u0161inimas pana\u0161us \u012f <em>Tramadolis<\/em><\/li>\n\n\n\n<li><strong>Cardia GFE et al. (2018)<\/strong> - \u201e<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5878871\/\" target=\"_blank\" rel=\"noreferrer noopener\">Levand\u0173 poveikis<em>&nbsp;(Lavandula angustifolia)<\/em>&nbsp;Eterinio aliejaus poveikis \u016bminiam u\u017edegiminiam atsakui<\/a>\u201e<br>Veikimo b\u016bdo priklausomyb\u0117 nuo doz\u0117s: <strong>Ma\u017eos doz\u0117s<\/strong>Prie\u0161u\u017edegiminis poveikis (ma\u017e\u0117ja NO, MPO, edema) - <strong>Didel\u0117s doz\u0117s<\/strong>Dirginantis (u\u017edegim\u0105 skatinantis) - Mechanizmas: <em>Prostanoidai, citokinai, NO, histaminas<\/em><\/li>\n\n\n\n<li><strong>Gostner JM ir kiti (2014)<\/strong> - \u201e<a href=\"https:\/\/link.springer.com\/article\/10.1186\/1472-6882-14-503\" target=\"_blank\" rel=\"noreferrer noopener\">Levand\u0173 aliejus slopina indoleamino 2,3-dioksigenaz\u0117s aktyvum\u0105 \u017emogaus PBMC<\/a>\u201e<br>Inhibuoja IDO (<em>Indoleamino 2,3-dioksigenaz\u0117<\/em>) - svarbus autoimunitetui - Suma\u017eintas <em>Triptofano skilimas<\/em> ir <em>Neopterinas<\/em> (imuninio aktyvumo \u017eymuo) - svarbus l\u0117tiniam imuniniam aktyvumui, autoimuniniams sindromams.<\/li>\n<\/ul>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Eukalyptus\"><\/span>Eukaliptas<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Pagrindin\u0117 eukalipto veiklioji med\u017eiaga <em>1,8-cineolas<\/em> suaktyvina makrofagus - imunin\u0117s sistemos \u0161iuk\u0161li\u0173 \u0161alinimo l\u0105steles. J\u0173 u\u017eduotis - i\u0161valyti l\u0105steli\u0173 liku\u010dius, negyvas l\u0105steles ir u\u017edegimines med\u017eiagas. Eukalipto savyb\u0117 yra makrofag\u0173 suaktyvinimas min\u0117ta kryptimi, o sergant autoimunin\u0117mis ligomis makrofagai pernelyg uoliai puola ir sveikas l\u0105steles bei audinius, o tai duoda prie\u0161ing\u0105 rezultat\u0105.<\/p>\n\n\n\n<p>Suma\u017e\u0117ja patinimas, tod\u0117l suma\u017e\u0117ja spaudimas, tod\u0117l s\u0105nariai tampa judresni ir suma\u017e\u0117ja skausmas, taip pat slopinami skausmo pasiuntiniai.<\/p>\n\n\n\n<p>Kartu pager\u0117jusi savijauta turi geresn\u0117s nuotaikos poveik\u012f, kuris ma\u017eina depresij\u0105, ypa\u010d l\u0117tinio skausmo atveju.<\/p>\n\n\n\n<p>Taigi, eukaliptas yra<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Reumatoidinis artritas<\/li>\n\n\n\n<li>Kv\u0117pavimo tak\u0173 autoimunin\u0117s ligos<\/li>\n\n\n\n<li>S\u0105nari\u0173 skausmas<\/li>\n<\/ul>\n\n\n\n<p>veiksmingas, kaip rodo \u0161ie tyrimai:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Yin C ir kiti (2020)<\/strong> - \u201e<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7161556\/\" target=\"_blank\" rel=\"noreferrer noopener\">Eukaliptolis ma\u017eina u\u017edegim\u0105 ir skausmo reakcijas pel\u0117s podagros artrito modelyje<\/a>\u201e<br>Podagrinio artrito pel\u0117s modelis - Eukaliptolis ma\u017eina skausm\u0105 ir patinim\u0105 priklausomai nuo doz\u0117s - Veiksmingumas pana\u0161us \u012f indometacino (NVNU) - Slopina NLRP3 inflamazomos aktyvacij\u0105 - Ma\u017eina oksidacin\u012f stres\u0105 (did\u0117ja SOD, CAT, GPx; ma\u017e\u0117ja ROS) - Slopina TRPV1 (skausmo receptoriaus) hiperekspresij\u0105 - Mechanizmas: antioksidacinis poveikis \u2192 slopina NLRP3 \u2192 ma\u017eina IL-1\u03b2<\/li>\n\n\n\n<li><strong>Juergens UR ir kt. (2004)<\/strong> - \u201eI<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15477123\/\" target=\"_blank\" rel=\"noreferrer noopener\">1,8-cineolio (eukaliptolio) slopinamasis poveikis citokin\u0173 gamybai kultivuojamuose \u017emogaus limfocituose ir monocituose<\/a>\u201e<br>Fundamentalus imunini\u0173 l\u0105steli\u0173 tyrimas - <strong>\u017dmogaus limfocitai:<\/strong> 1,5 \u03bcg\/ml (10-\u2075M) reik\u0161mingai slopino: TNF-\u03b1 - 92%, IL-1\u03b2 - 84%, IL-4 - 70%, IL-5 - 65% -. <strong>\u017dmogaus monocitai:<\/strong> Ta pati koncentracija slopino TNF-\u03b1 99%, IL-1\u03b2 84%, IL-6 76%, IL-8 65% - Mechanizmas: NF-\u03baB slopinimas - Terapin\u0117s koncentracijos be citotoksi\u0161kumo<\/li>\n\n\n\n<li><strong>Greiner JFW ir kiti (2013)<\/strong> - \u201e<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0167488913002747\" target=\"_blank\" rel=\"noopener\">1,8-cineolis slopina NF-\u03baB p65 branduolio translokacij\u0105 ir nuo NF-\u03baB priklausom\u0105 transkripcijos aktyvum\u0105<\/a>\u201e<br>Molekulinis NF-\u03baB mechanizmas - 1,8-cineolis blokuoja NF-\u03baB p65 translokacij\u0105 \u012f l\u0105stel\u0117s branduol\u012f - Slopina nuo NF-\u03baB priklausom\u0105 transkripcijos aktyvum\u0105 - Priklausomai nuo doz\u0117s didina I\u03baB\u03b1 kiek\u012f - Veikia MAPK keli\u0105<\/li>\n\n\n\n<li><strong>Khan A ir kiti (2014)<\/strong> - \u201e<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24379109\/\" target=\"_blank\" rel=\"noreferrer noopener\">1,8-cineolas (eukaliptolis) ma\u017eina amiloidu beta toksi\u0161kai paveikt\u0173 PC12 l\u0105steli\u0173 u\u017edegim\u0105<\/a>\u201e<br>Neurou\u017edegimas (aktualu i\u0161s\u0117tinei sklerozei) - Suma\u017e\u0117jo TNF-\u03b1, IL-1\u03b2, IL-6 neuronin\u0117se l\u0105stel\u0117se - Suma\u017e\u0117jo NF-\u03baB aktyvavimas - Antioksidacinis poveikis (padid\u0117jo SOD, CAT, GSH) - Aktualu neurodegeneracin\u0117ms autoimunin\u0117ms ligoms<\/li>\n\n\n\n<li><strong>Venkataraman B ir kiti (2023)<\/strong> - \u201e<a href=\"https:\/\/www.mdpi.com\/1422-0067\/24\/7\/6160\" target=\"_blank\" rel=\"noreferrer noopener\">Molekulinis dokavimas: 1,8-cineolas (eukaliptolis) yra naujas PPAR\u03b3 agonistas, ma\u017einantis storosios \u017earnos u\u017edegim\u0105<\/a>\u201e<br>PPAR\u03b3 agonistas sergant kolitu - 1,8-cineolis jungiasi prie PPAR\u03b3 (kaip ir tiazolidinedionai sergant cukriniu diabetu) - Suma\u017e\u0117jo kolito simptom\u0173 DSS sukeltame modelyje - Suma\u017e\u0117jo MPO aktyvumas, IL-6, TNF-\u03b1, iNOS - Padid\u0117jo IL-10 (prie\u0161u\u017edegiminis) - Mechanizmas<strong>:<\/strong> PPAR\u03b3 aktyvavimas \u2192 slopina NF-\u03baB<\/li>\n\n\n\n<li><strong>Jun YS ir kt. (2013)<\/strong> - \u201e<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3703330\/\" target=\"_blank\" rel=\"noreferrer noopener\">Eukalipto aliejaus inhaliacijos poveikis skausmui ir u\u017edegimin\u0117ms reakcijoms po kelio s\u0105nario endoprotezavimo operacijos<\/a>\u201e<br>Klinikinis kelio s\u0105nario endoprotezavimo tyrimas - Eukalipto inhaliacijos po TKR reik\u0161mingai suma\u017eino skausm\u0105 - Suma\u017eino CRP (C reaktyvusis baltymas) - U\u017edegimo \u017eymenis - Suma\u017eino kraujosp\u016bd\u012f (parasimpatinis suaktyv\u0117jimas) - 1,8-cineolis slopina T limfocit\u0173 citokin\u0173 sekrecij\u0105 - Slopina edemos susidarym\u0105<\/li>\n\n\n\n<li><strong>Brown SK ir kiti (2017)<\/strong> - Ap\u017evalga: \u201e<a href=\"https:\/\/www.researchgate.net\/publication\/318342501_18-cineole_An_Underappreciated_Anti-inflammatory_Therapeutic\" target=\"_blank\" rel=\"noreferrer noopener\">1,8-cineolas: nepakankamai \u012fvertintas prie\u0161u\u017edegiminis vaistas<\/a>\u201e<br>Keletas klinikini\u0173 tyrim\u0173 rodo stipr\u0173 prie\u0161u\u017edegimin\u012f poveik\u012f - Naudojamas sergant artritu, 2 tipo diabetu, \u0161irdies ir kraujagysli\u0173 ligomis - Kaip pirminis gydymas arba kaip papildoma priemon\u0117 sintetiniams vaistams - Saugus profilis, nedidelis \u0161alutinis poveikis<\/li>\n\n\n\n<li><strong>Salvatori G ir kiti (2023)<\/strong> - \u201e<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2023\/2582698\" target=\"_blank\" rel=\"noreferrer noopener\">Eucalyptus spp. eterini\u0173 aliej\u0173 prie\u0161u\u017edegiminis ir antimikrobinis poveikis<\/a>\u201e<br>Antimikrobinis ir prie\u0161u\u017edegiminis poveikis - 1,8-cineolis slopina arachidono r\u016bg\u0161ties keli\u0105 \u2192 slopina u\u017edegimo mediatorius - Bendras mechanizmas su gliukokortikoidais - \u03b1-pinenas (taip pat eukalipto sud\u0117tyje): Eukaliptolis slopina TNF, IL-1, leukotrienus, tromboksanus, tromboksan\u0105.<\/li>\n<\/ul>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Nelke\"><\/span>Gvazdikai<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><strong>Urvas<\/strong>Gvazdik\u0117li\u0173 aliejus gali sustiprinti krauj\u0105 skystinan\u010di\u0173 vaist\u0173 poveik\u012f!<\/p>\n\n\n\n<p>Eugenolis, pagrindin\u0117 gvazdik\u0117li\u0173 aliejaus veiklioji med\u017eiaga, blokuoja ferment\u0105 COX-2, kuris gamina u\u017edegim\u0105 sukelian\u010dias med\u017eiagas (prostaglandinus), taip pat NF-\u03baB, kurie abu sukelia \u012fprastus u\u017edegimo simptomus, tokius kaip paraudimas, skausmas, patinimas ir kt.<\/p>\n\n\n\n<p>Jis pertraukia prie\u017eastini\u0173 med\u017eiag\u0173 signalinius kelius keliuose ta\u0161kuose, tod\u0117l yra veiksmingas<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>sunkus s\u0105nari\u0173 u\u017edegimas<\/li>\n\n\n\n<li>\u016amus skausmas<\/li>\n\n\n\n<li>sisteminiai u\u017edegimai<\/li>\n<\/ul>\n\n\n\n<p>kaip patvirtina toliau pateikiami tyrimai:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Kang HJ ir kiti (2024)<\/strong> - \u201e<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1567576923018064\" target=\"_blank\" rel=\"noreferrer noopener\">Eugenolis palengvina eksperimentinio autoimuninio encefalomielito simptomus pel\u0117ms, slopindamas u\u017edegimines reakcijas<\/a>\u201e<br>I\u0161s\u0117tin\u0117s skleroz\u0117s EAE modelis - MOG sukelta EAE C57BL\/6 pel\u0117ms - Kasdienis geriamasis eugenolio vartojimas reik\u0161mingai suma\u017eino klinikinius simptomus - Suma\u017eino imunini\u0173 l\u0105steli\u0173 infiltracij\u0105 ir prou\u017edegimini\u0173 mediatori\u0173 kiek\u012f - Histologija: suma\u017e\u0117j\u0119s u\u017edegimas ir demielinizacija nugaros smegenyse - Mechanizmas: prie\u0161u\u017edegiminis, antioksidacinis, neuroprotekcinis.<\/li>\n\n\n\n<li><strong>Ferrari JG ir kt. (2025)<\/strong> - \u201e<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12290672\/\" target=\"_blank\" rel=\"noreferrer noopener\">Eugenolio, bis-eugenolio ir gvazdik\u0117li\u0173 eterinio aliejaus antioksidacinis ir prie\u0161u\u017edegiminis aktyvumas<\/a>\u201e<br>TLR4\/NF-\u03baB kelias - LPS stimuliuojam\u0173 makrofag\u0173 tyrimas in vitro - Eugenolis ir gvazdik\u0117li\u0173 aliejus reik\u0161mingai suma\u017eino TLR4 kiek\u012f - NF-\u03baB aktyvavimas slopinamas - <strong>Bis-eugenolis (dimerin\u0117 forma):<\/strong> Vienintel\u0117 med\u017eiaga, kuri vienu metu slopino TLR4\/NF-\u03baB, reguliavo NRF2 (antioksidantas) ir didino IL-10 (prie\u0161u\u017edegiminis poveikis) - DPPH radikal\u0173 \u0161alinimo aktyvumas: ~80%, esant 25 \u03bcg\/ml - TNF-\u03b1 kiekis suma\u017e\u0117jo esant visoms koncentracijoms<\/li>\n\n\n\n<li><strong>Barboza JN ir kiti (2018)<\/strong> - Ap\u017evalga: \u201e<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6217746\/\" target=\"_blank\" rel=\"noreferrer noopener\">Eugenolio prie\u0161u\u017edegiminis potencialas ir antioksidacinis profilis<\/a>\u201e<br>slopina NF-\u03baB signalin\u012f keli\u0105 (p50\/p65 fosforilinimas) - ma\u017eina COX-2, TNF-\u03b1, IL-6, IL-1\u03b2, NO - gerina antioksidacini\u0173 ferment\u0173: SOD, CAT, GPx, GST - plau\u010di\u0173 pa\u017eeidimo atveju: ma\u017e\u0117ja neutrofil\u0173 infiltracija, TNF-\u03b1, NF-\u03baB - dozavimas: 10,7 mg\/kg\/dien\u0105 \u017eiurk\u0117ms parod\u0117 optimal\u0173 poveik\u012f<\/li>\n\n\n\n<li><strong>Daniel AN ir kt. (2009)<\/strong> - \u201e<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22420667\/\" target=\"_blank\" rel=\"noreferrer noopener\">Gvazdik\u0117li\u0173 ir eugenolio necitotoksin\u0117s koncentracijos veikia imunomoduliuojan\u010diai ir (arba) prie\u0161u\u017edegimi\u0161kai<\/a>\u201e<br>Imunomoduliacija - Makrofagai inkubuoti su gvazdik\u0117li\u0173 aliejumi ir eugenoliu (24 val.) - Gvazdik\u0117li\u0173 aliejus (100 \u03bcg\/val.) slopino IL-1\u03b2, IL-6, IL-10 - Eugenolis (50-100 \u03bcg\/val.) slopino IL-6 ir IL-10 - Veik\u0117 prevenci\u0161kai ir terapi\u0161kai prie\u0161 LPS stimuliacij\u0105 - Mechanizmas: eugenolio NF-\u03baB slopinimas<\/li>\n\n\n\n<li><strong>Khalil AA ir kiti (2021)<\/strong> - Ap\u017evalga: \u201eEugenolio biologin\u0117s savyb\u0117s\u201c<br>Inhibuoja 5-LOX ir COX-2 (dvigubas poveikis!) - Neleid\u017eia neutrofil\u0173 ir makrofag\u0173 chemotaksiui - Inhibuoja prostaglandin\u0173 ir leukotrien\u0173 sintez\u0119 - Eugenolio dimerai pasi\u017eymi chemoprofilaktin\u0117mis savyb\u0117mis - Gali pakeisti NVNU osteoartrito ir u\u017edegimini\u0173 lig\u0173 atveju - Saugi doz\u0117: 2,5 mg\/kg k\u016bno svorio<\/li>\n<\/ul>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Teebaum\"><\/span>Arbatmedis<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Terpinen-4-olis, pagrindin\u0117 arbatmed\u017eio aliejaus veiklioji med\u017eiaga, ramina monocitus ir makrofagus - imunines l\u0105steles, kurios yra pernelyg aktyvios sergant daugeliu autoimunini\u0173 lig\u0173: Jos masi\u0161kai migruoja \u012f audinius, kur i\u0161skiria didel\u012f kiek\u012f u\u017edegimo pasiuntini\u0173 ir kvie\u010dia kitas imunines l\u0105steles. Arbatmed\u017eio aliejus nutraukia \u0161\u012f savaime atsinaujinant\u012f u\u017edegimin\u012f cikl\u0105.<\/p>\n\n\n\n<p>Be to, kad ma\u017eina u\u017edegimo pasiuntini\u0173, toki\u0173 kaip TNF-\u03b1, IL-1\u03b2 ir kit\u0173 agresyvi\u0173 signalini\u0173 molekuli\u0173, kiek\u012f, jo stiprus antimikrobinis poveikis (bakterij\u0173, virus\u0173, grybeli\u0173) ma\u017eina autoimuninius atkry\u010dius ir moduliuoja ne tik monocit\u0173, bet ir leukocit\u0173, balt\u0173j\u0173 kraujo k\u016bneli\u0173, veikl\u0105, tod\u0117l, be kita ko, pasi\u017eymi pla\u010diu veiksmingumu<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Odos autoimunin\u0117s ligos<\/li>\n\n\n\n<li>sisteminiai u\u017edegimai<\/li>\n\n\n\n<li>kaip platus imuninis modulis<\/li>\n<\/ul>\n\n\n\n<p>kaip rodo \u0161ie tyrimai:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Hart PH ir kiti (2000)<\/strong> - \u201e<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11131302\/\" target=\"_blank\" rel=\"noreferrer noopener\">Terpinen-4-olis, pagrindin\u0117 Melaleuca alternifolia (arbatmed\u017eio aliejaus) eterinio aliejaus sudedamoji dalis, slopina aktyvuot\u0173 \u017emogaus monocit\u0173 u\u017edegimo mediatori\u0173 gamyb\u0105<\/a>\u201e<br>Pagrindinis \u017emogaus monocit\u0173 tyrimas - <strong>\u017dmogaus periferinio kraujo monocitai<\/strong> (ne gyv\u016bn\u0173 modelis) - Vandenyje tirp\u016bs komponentai 0,125% suma\u017eino: TNF-\u03b1 - ~ 50%, IL-1\u03b2 - ~ 50%, IL-10 - ~ 50%, PGE2 - ~ 30% - Aktyvus buvo tik terpinen-4-olis (ne \u03b1-terpineolis ar 1,8-cineolis) - Vis\u0173 penki\u0173 mediatori\u0173 slopinimas: TNF-\u03b1, IL-1\u03b2, IL-8, IL-10, PGE2<\/li>\n\n\n\n<li><strong>Nogueira MNM ir kt. (2014)<\/strong> - \u201eTerpinen-4-olis ir alfa-terpineolis (arbatmed\u017eio aliejaus sudedamosios dalys) slopina IL-1\u03b2, IL-6 ir IL-10 gamyb\u0105 \u017emogaus makrofaguose\u201c<br>Mechanizmo tyrimas - U937 makrofagai (\u017emogaus l\u0105steli\u0173 linija) - TTO ir terpinen-4-olis reik\u0161mingai suma\u017eino IL-1\u03b2, IL-6, IL-10 - Mechanizmas<strong>:<\/strong> Poveikis NF-\u03baB, p38 arba ERK MAPK keliams - Poveikis pasirei\u0161kia ne per NF-\u03baB\/p38 aktyvacijos poky\u010dius, o per tolesnius - Poveikis TLR4 ir TLR2\/TLR4 aktyvacijai<\/li>\n\n\n\n<li><strong>Carson CF ir kt. (2006)<\/strong> - \u201e<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC1360273\/\" target=\"_blank\" rel=\"noreferrer noopener\">Melaleuca alternifolia (arbatmed\u017eio) aliejus: antimikrobini\u0173 ir kit\u0173 vaistini\u0173 savybi\u0173 ap\u017evalga<\/a>\u201e<br>I\u0161sami ap\u017evalga - Sistemin\u0117 vis\u0173 imunomoduliacini\u0173 poveiki\u0173 ap\u017evalga - TTO slopina TNF-\u03b1, IL-1\u03b2, IL-10 (50%) ir PGE2 (30%) \u017emogaus monocituose - Terpinen-4-olis moduliuoja edemos susidarym\u0105 po histamino injekcijos - Suma\u017eina eritem\u0105 nikelio sukelto kontaktinio padid\u0117jusio jautrumo atveju - Vietinis naudojimas moduliuoja kontaktinio padid\u0117jusio jautrumo reakcij\u0105 pel\u0117ms<\/li>\n\n\n\n<li><strong>Ninomiya K ir kiti (2012)<\/strong> - \u201e<a href=\"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/36\/5\/36_b13-00033\/_html\/-char\/en\" target=\"_blank\" rel=\"noreferrer noopener\">U\u017edegimini\u0173 reakcij\u0173 slopinimas terpinen-4-oliu, taikant pel\u0117s burnos kandidoz\u0117s model\u012f<\/a>\u201e<br>Burnos kandidoz\u0117s modelis - Terpinen-4-olis (40 mg\/ml, 50 \u00b5l per burn\u0105) pra\u0117jus 3 val. po Candida infekcijos - \u017dymiai slopino mieloperooksidaz\u0117s aktyvum\u0105 - Suma\u017eino makrofag\u0173 u\u017edegiminio baltymo-2 (MIP-2) kiek\u012f - In vitro: 800 \u00b5g\/ml slopino citokin\u0173 gamyb\u0105 kultivuojamuose makrofaguose<\/li>\n<\/ul>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Thymian\"><\/span>\u010ciobreliai<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><strong>Urvas<\/strong>Atkreipkite d\u0117mes\u012f \u012f chemotip\u0105!<\/p>\n\n\n\n<p>Kaip paai\u0161kinta \u012fvade, kalbant apie chemotipus, kreiv\u0117 yra kitokia. Nors \u010diobreliai <em>Linalolis<\/em> d\u0117l savo raminamojo, moduliuojan\u010dio poveikio yra skiriamas autoimunin\u0117ms ligoms gydyti, \u010diobreliai turi <em>Thymol<\/em> d\u0117l savo intensyvi\u0173 imunostimuliuojan\u010di\u0173 savybi\u0173 yra neproduktyvus ir gali i\u0161provokuoti ligos atkryt\u012f, u\u017edegim\u0105 ir skausm\u0105.<\/p>\n\n\n\n<p>Tyrimo situacija d\u0117l \u010diobreli\u0173:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Gholijani N ir kiti (2015)<\/strong> - \u201e<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4708037\/\" target=\"_blank\" rel=\"noreferrer noopener\">Citokin\u0173 gamybos ir transkripcijos faktori\u0173 aktyvumo \u017emogaus Jurkat T l\u0105stel\u0117se moduliavimas timoliu ir karvakroliu<\/a>\u201e<br>T l\u0105steli\u0173 moduliacija (svarbiausias autoimuniteto tyrimas) - <strong>\u017dmogaus T l\u0105stel\u0117s<\/strong> (Jurkat T l\u0105steli\u0173 linija) - 25 \u00b5g\/ml timolio ir karvakrolio kiekis reik\u0161mingai suma\u017eino IL-2: nuo 119,4\u00b18 iki 66,9\u00b16,4 pg\/ml (timolis) ir 32,3\u00b13,6 pg\/ml (karvakrolis), IFN-\u03b3: nuo 423,7\u00b119,7 iki 311,9\u00b111,6 pg\/ml - Mechanizmas<strong>:<\/strong> NFAT-2 suma\u017e\u0117jo iki 44,2% (timolis) ir 91,4% (karvakrolis) - c-Fos suma\u017e\u0117jo iki 31,2% (timolis) ir 27,6% (karvakrolis) - NFAT-2 ir AP-1 yra labai svarb\u016bs T l\u0105steli\u0173 aktyvavimui autoimuniteto metu<\/li>\n\n\n\n<li><strong>Amirghofran Z et al. (2015)<\/strong> - \u201e<a href=\"https:\/\/www.tandfonline.com\/doi\/10.3109\/1547691X.2015.1029145?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub%20%200pubmed#d1e252\" target=\"_blank\" rel=\"noreferrer noopener\">Timolio ir karvakrolio moduliacinis poveikis u\u017edegimo transkripcijos veiksniams lipopolisacharidu apdorotuose makrofaguose<\/a>\u201e<br>Makrofag\u0173 tyrimas - J774.1 pel\u0117s makrofagai, stimuliuojami LPS - karvakrolis reik\u0161mingai suma\u017eino IL-1\u03b2 ir TNF-\u03b1 (baltymas + mRNA) - timolis reik\u0161mingai suma\u017eino IL-1\u03b2 - <strong>Western Blot:<\/strong> Abu suma\u017eino c-Fos, NFAT-1, NFAT-2 - Karvakrolis suma\u017eino fosfo-SAPK\/JNK ir fosfo-STAT3 - Moduliuoja JNK, STAT-3, AP-1, NFAT.<\/li>\n\n\n\n<li><strong>Horvath G ir kt. (2022)<\/strong> - \u201e<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9311800\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u010ciobreli\u0173 (Thymus vulgaris L.) eterini\u0173 aliej\u0173 antioksidacinis ir prie\u0161u\u017edegiminis poveikis<\/a>\u201e<br>Fenofaz\u0117s tyrimas - TEO nuo \u017eyd\u0117jimo prad\u017eios stipriai slopino IL-6, IL-8, IL-1\u03b2, TNF-\u03b1 - TEO nuo \u017eyd\u0117jimo pabaigos ma\u017eiau efektyviai - <strong>Ne tik timolis, bet ir vis\u0173 sudedam\u0173j\u0173 dali\u0173 sinergija<\/strong> Atsakingas - padid\u0117j\u0119s CAT ir SOD aktyvumas (antioksidantas)<\/li>\n\n\n\n<li><strong>Fachini-Queiroz FC ir kiti (2012)<\/strong> - \u201e<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2012\/657026\" target=\"_blank\" rel=\"noreferrer noopener\">Thymus vulgaris L. eterinio aliejaus sudedam\u0173j\u0173 dali\u0173 - timolio ir karvakrolio - poveikis u\u017edegiminei reakcijai<\/a>\u201e<br>Tyrimas in vivo - TEO ir karvakrolis slopino u\u017edegimin\u0119 edem\u0105 ir leukocit\u0173 migracij\u0105 - <strong>Svarbu:<\/strong> Timolis parod\u0117 <strong>dirginantis poveikis<\/strong> (chemoatraktantas) - Karvakrolis tur\u0117jo prie\u0161u\u017edegimin\u012f poveik\u012f - Karvakrolis (10mg\/aus\u012f) suma\u017eino edem\u0105<\/li>\n\n\n\n<li><strong>Gago C. ir kiti (2025)<\/strong> - \u201e<a href=\"https:\/\/www.mdpi.com\/1420-3049\/30\/11\/2450\" target=\"_blank\" rel=\"noreferrer noopener\">Eterini\u0173 aliej\u0173, turin\u010di\u0173 daug timolio, prie\u0161u\u017edegiminis aktyvumas<\/a>\u201e<br>Ap\u017evalga - Timolis (50 \u00b5g\/ml) slopino TLR4\/MyD88\/NF-\u03baB\/IL-1\u03b2 signalizacij\u0105 - U\u017ekirto keli\u0105 l\u0105steli\u0173 agregacijai, suma\u017eino nekroptoz\u0119 ir piroptoz\u0119 - Standartizuotas ekstraktas (0,3% timolio) HBEpC\/HTEpC: suma\u017eino NF-\u03baB p65 ir p52, suma\u017eino IL-1\u03b2, IL-8, Muc5ac - Timolis: FDA \u201evisuotinai pripa\u017eintas saugiu\u201c.\u201c<\/li>\n\n\n\n<li><strong>Waheed F ir kiti (2024)<\/strong> - \u201e<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/fsn3.4563\" target=\"_blank\" rel=\"noreferrer noopener\">\u010ciobreli\u0173 (Thymus spp.) fitocheminis profiliavimas ir terapinis potencialas: Vaistin\u0117 \u017eol\u0117<\/a>\u201e<br>I\u0161sami ap\u017evalga - Timolis ma\u017eina MAPK ir NF-\u03baB signalizavimo kelius - <strong>Imunomoduliuojantis poveikis autoimunin\u0117ms ligoms<\/strong> - Gali atkurti imunin\u0119 pusiausvyr\u0105 sutrikus imuninei reakcijai - Daug \u017eadanti nat\u016brali imunologini\u0173 sutrikim\u0173 gydymo priemon\u0117<\/li>\n<\/ul>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Rosmarin\"><\/span>Rosemary<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Pager\u0117ja kraujotaka, tod\u0117l \u012f u\u017edegimo pa\u017eeistas vietas patenka daugiau deguonies ir maistini\u0173 med\u017eiag\u0173, nes u\u017edegimo pa\u017eeist\u0173 audini\u0173 med\u017eiag\u0173 apykaita pagreit\u0117ja ir jiems reikia daugiau degal\u0173, kad gal\u0117t\u0173 gyti. Kartu reikia pa\u0161alinti atliekas ir u\u017edegimo tarpininkus, kurie kaupiasi, kai kraujotaka prasta, trukdo gijimui ir sukelia skausm\u0105.<\/p>\n\n\n\n<p>Tod\u0117l jis skatina gijimo procesus d\u0117l pager\u0117jusios kraujotakos, greitesnio u\u017edegim\u0105 sukelian\u010di\u0173 med\u017eiag\u0173 pa\u0161alinimo ir intensyvesnio atstatom\u0173j\u0173 med\u017eiag\u0173 (aminor\u016bg\u0161\u010di\u0173, vitamin\u0173, mineral\u0173) tiekimo.<\/p>\n\n\n\n<p>Suma\u017e\u0117ja raumen\u0173 ir s\u0105nari\u0173 skausmas. Pager\u0117jusi kraujotaka atpalaiduoja sukiet\u0117jusius raumenis, ma\u017eina sustingim\u0105 ir skatina judrum\u0105.<\/p>\n\n\n\n<p>Rozmarinas suaktyvina prot\u0105, o tai ypa\u010d svarbu l\u0117tinio nuovargio atvejais, nes \u201e<em>Nuovargis<\/em>\u201c (did\u017eiulis i\u0161sekimas) yra pagrindinis autoimunini\u0173 lig\u0173 simptomas. Atgaivinantis poveikis smegenims ir nerv\u0173 sistemai taip pat turi prie\u0161u\u017edegimin\u012f poveik\u012f, nes blokuoja u\u017edegiminius kelius (NF-\u03baB, COX-2).<\/p>\n\n\n\n<p>Tod\u0117l rozmarinas naudingas<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Reumatoidinis artritas<\/li>\n\n\n\n<li>Raumen\u0173 sustingimas<\/li>\n\n\n\n<li>L\u0117tinis nuovargis (nuovargis)<\/li>\n<\/ul>\n\n\n\n<p>kaip rodo toliau pateikiami tyrimai:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Beninc\u00e1 JP ir kt. (2011)<\/strong> - \u201e<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0308814610007661\" target=\"_blank\" rel=\"noreferrer noopener\">Prie\u0161u\u017edegimini\u0173 Rosmarinus officinalis L. savybi\u0173 analiz\u0117 pel\u0117ms<\/a>\u201e<br>Rozmarin\u0173 eterinis aliejus maiste suma\u017eino TNBS kolit\u0105 - Profilaktinis vartojimas: suma\u017eino pa\u017eeidim\u0173 skai\u010di\u0173, dr\u0117gn\u0105 svor\u012f, MPO aktyvum\u0105 - \u03b1-pinenas ir borneolis (kiti komponentai) sustiprino poveik\u012f - \u03b1-pinenas slopina NF-\u03baB translokacij\u0105 LPS stimuliuojamose THP-1 l\u0105stel\u0117se - 1,8-cineolis slopina prostaglandin\u0173 ir citokin\u0173 susidarym\u0105<\/li>\n\n\n\n<li><strong>Belkhodja H ir kiti (2021)<\/strong> - \u201e<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7871606\/\" target=\"_blank\" rel=\"noreferrer noopener\">Pipirm\u0117\u010di\u0173 ir rozmarin\u0173 eterini\u0173 aliej\u0173, esan\u010di\u0173 nanoemulsijos pavidalu, antiosteoartritinis potencialas<\/a>\u201e<br>Osteoartrito MIA modelis - Rozmarino nanoemulsija reik\u0161mingai suma\u017eino osteoartrito bal\u0105 - Suma\u017eino kremzl\u0117s irim\u0105 ir s\u0105nario u\u017edegim\u0105 - Histologija: ma\u017eesn\u0117 mononuklearini\u0173 l\u0105steli\u0173 infiltracija, storesn\u0117 kremzl\u0117 - Rozmarinas suma\u017eino migruojan\u010di\u0173 l\u0105steli\u0173 ir u\u017edegiminio eksudato kiek\u012f - <strong>Efektyvus formalino testas, vijimo testas, leten\u0173 edemos testas<\/strong><\/li>\n\n\n\n<li><strong>Borges RS ir kiti (2019)<\/strong> - \u201e<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378874118314107\" target=\"_blank\" rel=\"noreferrer noopener\">Vaistinio rozmarino (Rosmarinus officinalis) eterinis aliejus: fitochemija, prie\u0161u\u017edegiminis aktyvumas ir mechanizmai<\/a>\u201e<br>Ap\u017evalga - Pagrindin\u0117s sudedamosios dalys: 1,8-cineolas, \u03b1-pinenas, kamparas - Mechanizmai: Antioksidacinis aktyvumas u\u017ekerta keli\u0105 ROS \u017ealai - Lygi\u0173j\u0173 raumen\u0173 atsipalaidavimas (svarbus sergant kv\u0117pavimo tak\u0173 ligomis) - Ma\u017eas toksi\u0161kumas<\/li>\n\n\n\n<li><strong>Khalil DY ir Hassan OM (2024)<\/strong> - \u201e<a href=\"https:\/\/www.publishing.emanresearch.org\/Journal\/Abstract\/angiotherapy-849609\" target=\"_blank\" rel=\"noreferrer noopener\">Prie\u0161u\u017edegiminis ir antioksidacinis rozmarin\u0173 eterinio aliejaus poveikis<\/a>\u201e<br>Tyrimas Irake - GC-MS: eukaliptolis (34,25%), \u03b1-pinenas (20,98%), kamparas (13,75%) - baltym\u0173 denat\u016bracijos tyrimas: reik\u0161mingas prie\u0161u\u017edegiminis poveikis. <strong>Laisv\u0173j\u0173 radikal\u0173 slopinimo laipsnis: 87,45%<\/strong> - 50 mg\/ml koncentracija prilygsta diklofenako natrio druskos koncentracijai - Didelis antioksidacinis aktyvumas, prilygstantis troloxui<\/li>\n\n\n\n<li><strong>Zuzarte M ir kt. (2011)<\/strong> - \u201e<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21919504\/\" target=\"_blank\" rel=\"noreferrer noopener\">Lavandula viridis, Lavandula stoechas subsp. lusitanica ir Rosmarinus officinalis eterini\u0173 aliej\u0173 chemin\u0117 sud\u0117tis ir prie\u0161grybelinis aktyvumas<\/a>\u201e<br>Prie\u0161u\u017edegiminis ir antioksidacinis tyrimas - rozmarin\u0173 aliejus pasi\u017eym\u0117jo stipriu antioksidaciniu aktyvumu - slopino lipid\u0173 peroksidacij\u0105 - apsaugojo l\u0105steles nuo oksidacin\u0117s pa\u017eaidos<\/li>\n\n\n\n<li><strong>Ra\u0161kovi\u0107 A et al. (2014)<\/strong> - \u201e<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0378874114000725\" target=\"_blank\" rel=\"noreferrer noopener\">Rozmarin\u0173 (Rosmarinus officinalis L.) eterinio aliejaus antioksidacinis ir prie\u0161u\u017edegiminis aktyvumas<\/a>\u201e<br>In vivo u\u017edegimo modeliai - Karagenano sukelta leten\u0173 edema: nuo doz\u0117s priklausomas slopinimas - Formalino testas: reik\u0161mingas analgezinis poveikis - Poveikis pasirei\u0161kia abiejose bandymo faz\u0117se (neurogenin\u0117je ir u\u017edegimin\u0117je) - DPPH radikal\u0173 \u0161alinimo aktyvumas: IC50 = 8,7 mg\/ml - palyginamas su sintetiniais antioksidantais<\/li>\n<\/ul>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Zitrusole_Orange_Zitrone_Bergamotte\"><\/span>Citrusiniai aliejai (apelsin\u0173, citrin\u0173, bergamo\u010di\u0173)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Pagrindinis citrusini\u0173 vaisi\u0173 aliej\u0173 poveikis yra psichologinis, tod\u0117l jie taip pat veikia imunomoduliuojan\u010diai: pavyzd\u017eiui, d\u0117l l\u0117tinio skausmo ken\u010diantiems nuo depresijos taip pat silpn\u0117ja imunin\u0117 sistema. Tai u\u017eburtas ratas, kur\u012f citrusiniai aliejai gali nutraukti.<\/p>\n\n\n\n<p>Naudodami <em>Serotoninas<\/em>- ir <em>Dopaminas<\/em>-i\u0161siskyrimas smegenyse, jie pastebimai pakelia nuotaik\u0105, tod\u0117l suma\u017e\u0117ja nerimas ir depresija, kai nebedominuoja baim\u0117 d\u0117l atkry\u010dio, nerimas d\u0117l ateities ir nusivylimas d\u0117l apribojim\u0173.<\/p>\n\n\n\n<p>Jie netiesiogiai palaiko imunin\u0119 sistem\u0105 ma\u017eindami stres\u0105, nes gera nuotaika rei\u0161kia ma\u017eiau streso hormon\u0173, o tai savo ruo\u017etu rei\u0161kia geresn\u012f imunin\u0117s sistemos reguliavim\u0105.<\/p>\n\n\n\n<p>Antimikrobinis poveikis <em>Limes<\/em> taip pat tiesiogiai veikia bakterijas ir virusus, tod\u0117l gali u\u017ekirsti keli\u0105 infekcijoms, galin\u010dioms sukelti pa\u016bm\u0117jimus.<\/p>\n\n\n\n<p>Tod\u0117l citrin\u0173 aliejai yra veiksmingi<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>L\u0117tini\u0173 lig\u0173 sukelta depresija<\/li>\n\n\n\n<li>Streso valdymas<\/li>\n\n\n\n<li>ir kaip malonus mi\u0161ini\u0173 priedas<\/li>\n<\/ul>\n\n\n\n<p>remiantis \u0161i\u0173 tyrim\u0173 rezultatais:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Amorim JL ir kiti (2016)<\/strong> - \u201e<a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0153643\" target=\"_blank\" rel=\"noreferrer noopener\">Prie\u0161u\u017edegimin\u0117s savyb\u0117s ir keturi\u0173 citrus\u0173 r\u016b\u0161i\u0173 eterini\u0173 aliej\u0173 cheminis apib\u016bdinimas<\/a>\u201e<br>Keturi\u0173 citrus\u0173 r\u016b\u0161i\u0173 - C. limon, C. aurantifolia, C. limonia pasi\u017eym\u0117jo prie\u0161u\u017edegiminiu poveikiu - Suma\u017e\u0117jo l\u0105steli\u0173 migracija, citokin\u0173 gamyba, baltym\u0173 ekstravazacija (karageninas) - Grynas limonenas pasi\u017eym\u0117jo tokiu pat poveikiu kaip ir visi aliejai - limonenas (31,1-65,7%), \u03b2-pinenas (5,1-13,1%), \u03b3-terpinenas (10,8-12,2%) - Limonenas slopina l\u0105steli\u0173 migracij\u0105 ir citokin\u0173 gamyb\u0105<\/li>\n\n\n\n<li><strong>Kummer R ir kt. (2013)<\/strong> - \u201e<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3671226\/\" target=\"_blank\" rel=\"noreferrer noopener\">Citrus latifolia Tanaka eterinio aliejaus ir limoneno prie\u0161u\u017edegiminio aktyvumo \u012fvertinimas<\/a>\u201e<br>Citrus latifolia\/limonenas - Limonenas (62% aliejaus) suma\u017eino neutrofil\u0173 migracij\u0105 \u012f fMLP ir LTB4 - 500mg\/kg limoneno reik\u0161mingai suma\u017eino TNF-\u03b1 kiek\u012f - Mechanizmas: prou\u017edegimini\u0173 mediatori\u0173 slopinimas eksudate - leukocit\u0173 chemotaksio slopinimas - In vitro: 1, 3, 10\u00b5g\/ml limoneno veiksmingumas<\/li>\n\n\n\n<li><strong>Yoon WJ ir kiti (2010)<\/strong> - \u201e<a href=\"https:\/\/ift.onlinelibrary.wiley.com\/doi\/10.1111\/j.1750-3841.2010.01541.x\" target=\"_blank\" rel=\"noreferrer noopener\">Limoneno i\u0161 Yuzu (Citrus junos Tanaka) eterinio aliejaus prie\u0161u\u017edegiminis poveikis eozinofilams<\/a>\u201e<br>Eozinofil\u0173 tyrimas - Limonenas (7,34 mM) slopino ROS gamyb\u0105 eotaksinu stimuliuojamose HL-60 l\u0105stel\u0117se - 14,68 mM suma\u017eino MCP-1 gamyb\u0105 per NF-\u03baB aktyvacij\u0105 - Palygintinas su proteasomos inhibitoriumi MG132 - L\u0105steli\u0173 chemotaks\u0117s slopinimas priklausomas nuo p38 MAPK (kaip ir SB203580) - Galimyb\u0117 gydyti astm\u0105 slopinant citokinus ir ROS<\/li>\n\n\n\n<li><strong>Hirota R ir kiti (2010)<\/strong> - \u201e<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0278691513002007\" target=\"_blank\" rel=\"noreferrer noopener\">Prie\u0161u\u017edegiminis eterinio aliejaus poveikis blokuojant JNK, ERK ir NF-\u03baB kelius<\/a>\u201e<br>Citrinmedis (C. medica) - Limonenas (52,44%) + \u03b3-terpinenas (28,41%) = 98,97% aliejaus - Slopino NO ir PGE2, slopindamas iNOS ir COX-2 - Slopino TNF-\u03b1, IL-1\u03b2, IL-6 - Mechanizmas<strong>:<\/strong> NF-\u03baB aktyvacija sustabdyta, I\u03baB-\u03b1 fosforilinimas slopinamas - Papildomai: JNK ir ERK kelio slopinimas<\/li>\n\n\n\n<li><strong>Lee GH ir kiti (2023)<\/strong> - \u201e<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10301132\/\" target=\"_blank\" rel=\"noreferrer noopener\">Citrusini\u0173 veisli\u0173 \u017eieveli\u0173 eterini\u0173 aliej\u0173 prie\u0161u\u017edegiminis poveikis<\/a>\u201e<br>21 citrus\u0173 veisli\u0173 atranka - C. japonica ir C. maxima pasi\u017eym\u0117jo geresniu prie\u0161u\u017edegiminiu poveikiu - Slopino u\u017edegimo mediatori\u0173 ir prou\u017edegimini\u0173 citokin\u0173 rai\u0161k\u0105 - Veikliosios sudedamosios dalys: \u03b1-pinenas, mircenas, limonenas, \u03b2-ocimenas, linalolis, \u03b1-terpineolis - <strong>\u03b1-terpineolis pasi\u017eym\u0117jo stipriausiu prie\u0161u\u017edegiminiu poveikiu<\/strong> - Limonenas buvo pagrindin\u0117 vis\u0173 21 aliejaus sudedamoji dalis<\/li>\n\n\n\n<li><strong>El Omari N ir kt. (2024)<\/strong> - \u201e<a href=\"https:\/\/www.mdpi.com\/1424-8247\/17\/12\/1652\" target=\"_blank\" rel=\"noreferrer noopener\">Citrus sinensis eterinio aliejaus chemin\u0117 sud\u0117tis ir prie\u0161u\u017edegiminio bei antioksidacinio poveikio \u012fvertinimas<\/a>\u201e<br>Citrus sinensis\/Limoneno ap\u017evalga - Limonenas (70,15%) kaip pagrindin\u0117 sudedamoji dalis - Nuo doz\u0117s priklausomas NO ir PGE2 ma\u017einimas RAW 264.7 makrofaguose - Elastaz\u0117s slopinimas (IC50 = 65,72 \u00b5g\/ml), tirozinaz\u0117s (IC50 = 102 \u00b5g\/ml) - Geresnis nei kvercetino standartas - Dermatoprotekcinis poveikis - aktualus psoriazei, odos autoimunitetui<\/li>\n<\/ul>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Ol-Kombinationen_fur_verschiedene_Autoimmunerkrankungen\"><\/span>Aliej\u0173 deriniai \u012fvairioms autoimunin\u0117ms ligoms gydyti<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Multiple_Sklerose_MS\"><\/span>I\u0161s\u0117tin\u0117 skleroz\u0117 (MS)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>3 la\u0161ai <strong>Copaiba<\/strong> (nerv\u0173 apsauga, remielinizacija)<br>2 la\u0161ai <strong>Smilkalai<\/strong> (prie\u0161u\u017edegiminis)<br>2 la\u0161ai <strong>Raudon\u0117lis<\/strong> (T l\u0105steli\u0173 pusiausvyra)<br>1 la\u0161as <strong>Levand\u0173<\/strong> (Stresas)<\/p>\n\n\n\n<p>30 ml <strong>Ne\u0161an\u010dioji alyva<\/strong> (pvz., simondsij\u0173 aliejus)<\/p>\n\n\n\n<p><strong>Taikymas:<\/strong><br>Masa\u017euokite kakl\u0105 ir stubur\u0105 du kartus per dien\u0105<br>Papildomai \u012fkv\u0117pti (1-2 la\u0161ai ant nosin\u0117s)<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Rheumatoide_Arthritis\"><\/span>Reumatoidinis artritas<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>3 la\u0161ai <strong>Smilkalai<\/strong> (kremzli\u0173 apsauga, leukotrien\u0173 slopinimas)<br>2 la\u0161ai <strong>Eukaliptas<\/strong> (makrofag\u0173 moduliacija)<br>2 la\u0161ai <strong>Rosemary<\/strong> (kraujotaka)<br>1 la\u0161as <strong>Gvazdikai<\/strong> (COX-2 slopinimas)<\/p>\n\n\n\n<p>30 ml <strong>Ne\u0161an\u010dioji alyva<\/strong><\/p>\n\n\n\n<p><strong>Taikymas:<\/strong><br>Tepkite tiesiai ant pa\u017eeist\u0173 s\u0105nari\u0173<br>\u0160velniai masa\u017euokite<br>2-3 kartus per dien\u0105<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Morbus_Crohn_Colitis\"><\/span>Krono liga \/ kolitas<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>3 la\u0161ai <strong>Smilkalai<\/strong> (b\u016bdinga \u017earnynui)<br>2 la\u0161ai <strong>Levand\u0173<\/strong> (\u017earnyno ir smegen\u0173 a\u0161is, stresas)<br>2 la\u0161ai <strong>\u010ciobreliai Linalolis <\/strong>(\u0161velnus antimikrobinis poveikis)<br>1 la\u0161as <strong>Bergamot\u0117s<\/strong> (nuotaika)<\/p>\n\n\n\n<p>30 ml <strong>Ne\u0161an\u010dioji alyva<\/strong><\/p>\n\n\n\n<p><strong>Taikymas:<\/strong><br>Masa\u017euokite pilv\u0105 pagal laikrod\u017eio rodykl\u0119<br>Nuo m\u0117\u0161lungio kaip \u0161iltas kompresas<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Lupus_Systemischer_Lupus_Erythematodes\"><\/span>Lupus (sistemin\u0117 raudonoji vilklig\u0117)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>3 la\u0161ai <strong>Copaiba<\/strong> (CB2 sistema)<br>2 la\u0161ai <strong>Levand\u0173<\/strong> (oksidacinis stresas)<br>2 la\u0161ai <strong>Raudon\u0117lis<\/strong> (T l\u0105steli\u0173 pusiausvyra)<br>1 la\u0161as <strong>Arbatmed\u017eio aliejus<\/strong> (monocit\u0173 moduliacija)<\/p>\n\n\n\n<p>30 ml <strong>Ne\u0161an\u010dioji alyva<\/strong><\/p>\n\n\n\n<p><strong>Taikymas:<\/strong><br>Ypa\u010d s\u0105nari\u0173 ir skausming\u0173 viet\u0173<br>Viso k\u016bno masa\u017eas (venkite saul\u0117s ap\u0161viest\u0173 viet\u0173)<\/p>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wechselwirkungen_mit_Biologika\"><\/span>S\u0105veika su biologiniais vaistais<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Was_sind_Biologika\"><\/span>Kas yra biologiniai vaistai?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Biologiniai vaistai - tai biotechnologiniu b\u016bdu pagaminti vaistai, specialiai veikiantys imunin\u0119 sistem\u0105. Jais gydomos vidutinio sunkumo ir sunkios autoimunin\u0117s ligos.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Hauptklassen_der_Biologika\"><\/span>Pagrindin\u0117s biologini\u0173 vaist\u0173 klas\u0117s<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"TNF-%CE%B1-Inhibitoren\"><\/span><strong>TNF-\u03b1 inhibitoriai<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>Blokuoti naviko nekroz\u0117s faktori\u0173 alfa - u\u017edegim\u0105 skatinant\u012f citokin\u0105, pvz.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Infliksimabas (Remicade)<\/li>\n\n\n\n<li>Adalimumabas (Humira)<\/li>\n\n\n\n<li>Etanerceptas (Enbrel)<\/li>\n<\/ul>\n\n\n\n<p>Naudojimas reumatoidiniam artritui, Krono ligai, opiniam kolitui, psoriazei gydyti<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Interleukin-Inhibitoren\"><\/span><strong>Interleukino inhibitoriai<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>Blokuoja specifinius interleukinus (IL-1, IL-6, IL-12\/23, IL-17, IL-23).<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Tocilizumabas (IL-6)<\/li>\n\n\n\n<li>Ustekinumabas (IL-12\/23)<\/li>\n\n\n\n<li>Sekukinumabas (IL-17)<\/li>\n<\/ul>\n\n\n\n<p>Naudojimas reumatoidiniam artritui, psoriazei, psoriaziniam artritui gydyti<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"B-Zell-Depletoren\"><\/span><strong>B l\u0105steli\u0173 depletoriai<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>Suma\u017e\u0117ja B limfocit\u0173, gaminan\u010di\u0173 antik\u016bnus.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Rituksimabas (MabThera)<\/li>\n<\/ul>\n\n\n\n<p>Vartojimas sergant reumatoidiniu artritu, tam tikrais vaskulitidais<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"T-Zell-Kostimulationshemmer\"><\/span><strong>T l\u0105steli\u0173 kostimuliacijos inhibitoriai<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>Blokuoja T l\u0105steli\u0173 aktyvavim\u0105.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Abataceptas (Orencia)<\/li>\n<\/ul>\n\n\n\n<p>Naudojimas reumatoidiniam artritui gydyti<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Integrin-Antagonisten\"><\/span><strong>Integrin\u0173 antagonistai<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>U\u017ekirsti keli\u0105 imunini\u0173 l\u0105steli\u0173 migracijai \u012f u\u017edegimo \u017eidinius.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Vedolizumabas (Entyvio)<\/li>\n\n\n\n<li>Natalizumabas (Tysabri)<\/li>\n<\/ul>\n\n\n\n<p>Naudojimas sergant l\u0117tine u\u017edegimine \u017earnyno liga, i\u0161s\u0117tine skleroze<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Potenzielle_additive_entzundungshemmende_Effekte\"><\/span>Galimas papildomas prie\u0161u\u017edegiminis poveikis<span class=\"ez-toc-section-end\"><\/span><\/h5>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>Eterinis aliejus<\/th><th>Pagrindin\u0117s veikliosios med\u017eiagos<\/th><th>Biologini\u0173 vaist\u0173 klas\u0117<\/th><th>Galimas sinergijos mechanizmas<\/th><th>Galimi privalumai<\/th><\/tr><\/thead><tbody><tr><td>Smilkalai (bosvelija)<\/td><td>Bosvelio r\u016bg\u0161tys<\/td><td>TNF-\u03b1 inhibitoriai<\/td><td>Leukotrien\u0173 slopinimas + TNF-\u03b1 blokada<\/td><td>Padid\u0117j\u0119s u\u017edegimo slopinimas<\/td><\/tr><tr><td>Ciber\u017eol\u0117 (eterinis aliejus)<\/td><td>Turmeron, ar-Turmeron<\/td><td>IL-6 inhibitoriai<\/td><td>NF-\u03baB slopinimas + IL-6 blokada<\/td><td>Suma\u017e\u0117j\u0119s sisteminis u\u017edegimas<\/td><\/tr><tr><td>Imbieras<\/td><td>Imbieriniai g\u0117rimai, \u0161okoladiniai g\u0117rimai<\/td><td>TNF-\u03b1 inhibitoriai<\/td><td>COX-2 slopinimas + TNF-\u03b1 ma\u017einimas<\/td><td>Skausmo mal\u0161inimas, u\u017edegimo ma\u017einimas<\/td><\/tr><tr><td>Levand\u0173<\/td><td>Linalolis, linalio acetatas<\/td><td>Visos klas\u0117s<\/td><td>Streso ma\u017einimas, kortizolio moduliacija<\/td><td>Geresn\u0117 lig\u0173 kontrol\u0117 valdant stres\u0105<\/td><\/tr><tr><td>Pipirm\u0117t\u0117s<\/td><td>Mentolis, mentonas<\/td><td>TNF-\u03b1 inhibitoriai<\/td><td>Vietinis skausmo mal\u0161inimas + sisteminis prie\u0161u\u017edegiminis poveikis<\/td><td>Simptom\u0173 palengvinimas<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h5 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Immunmodulatorische_Effekte\"><\/span>Imunomoduliacinis poveikis<span class=\"ez-toc-section-end\"><\/span><\/h5>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>Eterinis aliejus<\/th><th>Imuninis poveikis<\/th><th>Galima sinergija su biologiniais vaistais<\/th><th>Pastabos<\/th><\/tr><\/thead><tbody><tr><td>Arbatmed\u017eio aliejus<\/td><td>Antimikrobinis, imunostimuliatorius<\/td><td>Gali b\u016bti prie\u0161ingas imunosupresijai<\/td><td>Atsargiai, esant sunkiai imunosupresijai<\/td><\/tr><tr><td>\u010ciobreliai<\/td><td>Antimikrobinis, imunostimuliatorius<\/td><td>Gali apsaugoti nuo infekcij\u0173<\/td><td>Gal\u0117t\u0173 suma\u017einti infekcijos rizik\u0105<\/td><\/tr><tr><td>Raudon\u0117lis<\/td><td>Labai antimikrobinis<\/td><td>Galimai apsauginis imunosupresijos atveju<\/td><td>Tik labai atskiestas ir atsargiai<\/td><\/tr><tr><td>Ramun\u0117l\u0117s<\/td><td>Prie\u0161u\u017edegiminis, raminantis<\/td><td>Papildomas prie\u0161u\u017edegiminis poveikis<\/td><td>Gerai toleruojamas, n\u0117ra imunostimuliacijos<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Theoretische_Risiken\"><\/span>Teorin\u0117 rizika<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Verstarkte_Immunsuppression\"><\/span><strong>Padid\u0117jusi imunosupresija<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>Biologiniai vaistai specialiai slopina imunin\u0117s sistemos dalis. Kai kurie eteriniai aliejai gali sustiprinti \u0161\u012f poveik\u012f:<\/p>\n\n\n\n<p><strong>Rizikos scenarijus:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Mechanizmas:<\/strong> Papildomas imunosupresinis poveikis<\/li>\n\n\n\n<li><strong>Susij\u0119 aliejai:<\/strong> Smilkalai, mira (didel\u0117mis doz\u0117mis), ciber\u017eol\u0117<\/li>\n\n\n\n<li><strong>Pasekm\u0117s:<\/strong> Didesn\u0117 infekcijos rizika, u\u017edelstas \u017eaizd\u0173 gijimas<\/li>\n\n\n\n<li><strong>Klinikin\u0117 reik\u0161m\u0117:<\/strong> Tik\u0117tina, kad vartojant vietiniam naudojimui - ma\u017eai, vartojant per burn\u0105 - daugiau.<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Erhohtes_Infektionsrisiko\"><\/span><strong>Didesn\u0117 infekcijos rizika<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>Biologiniai vaistai didina bakterini\u0173, virusini\u0173 ir grybelini\u0173 infekcij\u0173, ypa\u010d tuberkulioz\u0117s ir oportunistini\u0173 infekcij\u0173, rizik\u0105.<\/p>\n\n\n\n<p><strong>Kritin\u0117s pastabos:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Imunostimuliuojantys aliejai:<\/strong> Teori\u0161kai gali susilpninti biologini\u0173 vaist\u0173 (pvz., arbatmed\u017eio aliejaus, raudon\u0117lio, \u010diobreli\u0173) poveik\u012f.<\/li>\n\n\n\n<li><strong>Antimikrobiniai aliejai:<\/strong> Gali tur\u0117ti apsaugin\u012f poveik\u012f, ta\u010diau negali pakeisti medicinin\u0117s infekcij\u0173 profilaktikos.<\/li>\n\n\n\n<li><strong>Paradoksas:<\/strong> Per didel\u0117 imunin\u0117 stimuliacija gali sustiprinti autoimunines reakcijas<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Allergische_Reaktionen_und_Hautreaktionen\"><\/span><strong>Alergin\u0117s reakcijos ir odos reakcijos<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>Pacientai, vartojantys biologinius vaistus, da\u017enai turi jautresn\u0119 od\u0105 ir pakitusi\u0105 imunin\u0119 sistem\u0105.<\/p>\n\n\n\n<p><strong>Rizika:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Eterini\u0173 aliej\u0173 sukeltas kontaktinis dermatitas<\/li>\n\n\n\n<li>Fotosensibilizacija (citrusiniai aliejai)<\/li>\n\n\n\n<li>Psoriaz\u0117s ar egzemos odos po\u017eymi\u0173 pa\u016bm\u0117jimas<\/li>\n\n\n\n<li>Reakcijos injekcij\u0173 vietose<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Leberstoffwechsel_und_Arzneimittelinteraktionen\"><\/span><strong>Kepen\u0173 metabolizmas ir vaist\u0173 s\u0105veika<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>Kai kurie eteriniai aliejai veikia citochromo P450 fermentus.<\/p>\n\n\n\n<p><strong>Galima s\u0105veika:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Aliejai, indukuojantys ir (arba) slopinantys CYP fermentus:<\/strong> Pipirm\u0117t\u0117s, greipfrutai, bergamot\u0117s<\/li>\n\n\n\n<li><strong>Rizika:<\/strong> Pakit\u0119s kit\u0173 vaist\u0173 klirensas (bet ne pa\u010di\u0173 biologini\u0173 vaist\u0173, nes jie yra proteoliti\u0161kai skaidomi).<\/li>\n\n\n\n<li><strong>Klinikin\u0117 reik\u0161m\u0117:<\/strong> Aktualiau, kai kartu vartojami DMARDS (pvz., metotreksatas)<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Spezifische_Uberlegungen_zu_Immunsuppressiva\"><\/span>Ypatingos pastabos d\u0117l imunosupresant\u0173<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"TNF-%CE%B1-Inhibitoren_Atherische_Ole\"><\/span>TNF-\u03b1 inhibitoriai + eteriniai aliejai<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p><strong>Vidutin\u0117 rizika:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Smilkalai: gali tur\u0117ti papildom\u0105 prie\u0161u\u017edegimin\u012f poveik\u012f, bet taip pat gali padidinti imunosupresij\u0105.<\/li>\n\n\n\n<li>Imbieras: palyginti saugus, daugiausia simptominis poveikis<\/li>\n\n\n\n<li>Ciber\u017eol\u0117: atsargiai vartojant dideles dozes, atkreipkite d\u0117mes\u012f \u012f kraujavimo rizik\u0105<\/li>\n<\/ul>\n\n\n\n<p><strong>Rekomendacija:<\/strong> Vietinis naudojimas tikriausiai yra saugus, aptarkite su gydytoju geriam\u0173j\u0173 papild\u0173 vartojim\u0105<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Interleukin-Inhibitoren_Atherische_Ole\"><\/span>Interleukino inhibitoriai + eteriniai aliejai<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p><strong>B\u016bkite ypa\u010d atsarg\u016bs:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>IL-17 inhibitoriai didina kandidoz\u0117s rizik\u0105: prie\u0161grybeliniai aliejai, pvz., arbatmed\u017eio aliejus, teori\u0161kai gal\u0117t\u0173 pad\u0117ti, ta\u010diau atsargiai, kai jie naudojami ant odos.<\/li>\n\n\n\n<li>IL-6 inhibitoriai: padid\u0117jusi infekcijos rizika, n\u0117ra stipri\u0173 imunosupresini\u0173 med\u017eiag\u0173<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"B-Zell-Depletoren_Rituximab\"><\/span>B l\u0105steli\u0173 depletoriai (rituksimabas)<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p><strong>Ypatingas atsargumas:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Stipriai imunosupresinis<\/li>\n\n\n\n<li>Ilgalaik\u0117 imunosupresija (6-12 m\u0117nesi\u0173)<\/li>\n\n\n\n<li>Venkite vis\u0173 imunomoduliuojan\u010di\u0173 eterini\u0173 aliej\u0173 terapin\u0117mis doz\u0117mis.<\/li>\n\n\n\n<li>Tik \u0161veln\u016bs, simptomus sukeliantys aliejai ma\u017eomis doz\u0117mis (levandos atsipalaidavimui).<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Praktische_Empfehlungen\"><\/span>Praktin\u0117s rekomendacijos<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Sichere_Anwendung_bei_Biologika-Therapie\"><\/span>Saugus naudojimas biologin\u0117s terapijos metu:<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Visada pasitarkite su gydan\u010diu reumatologu ir (arba) gastroenterologu<\/strong><\/li>\n\n\n\n<li><strong>Pageidautina vietiniam naudojimui<\/strong> (ma\u017eesn\u0117 sistemin\u0117 absorbcija)<\/li>\n\n\n\n<li><strong>Naudokite ma\u017eas koncentracijas<\/strong> (1-2% aliejuje su ne\u0161ikliu)<\/li>\n\n\n\n<li><strong>Antimikrobiniai aliejai:<\/strong> Tik jei to konkre\u010diai reikalaujama ir pasikonsultavus<\/li>\n\n\n\n<li><strong>Venkite imunostimuliuojan\u010di\u0173 aliej\u0173<\/strong> aktyvaus biologinio gydymo metu<\/li>\n\n\n\n<li><strong>Atlikite pleistro test\u0105<\/strong> d\u0117l padid\u0117jusio odos jautrumo.<\/li>\n<\/ol>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Relative_Sicherheit_%E2%80%93_Empfohlene_Ole\"><\/span>Santykinis saugumas - Rekomenduojamos alyvos:<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Levandos:<\/strong> Atsipalaidavimas, miego skatinimas<\/li>\n\n\n\n<li><strong>Ramun\u0117l\u0117s:<\/strong> Prie\u0161u\u017edegiminis, raminantis<\/li>\n\n\n\n<li><strong>Pipirm\u0117t\u0117s:<\/strong> Simptominis skausmo mal\u0161inimas (vietinis, praskiestas)<\/li>\n\n\n\n<li><strong>Imbieras:<\/strong> Pykinimas, vidutinio stiprumo prie\u0161u\u017edegiminis poveikis<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E2%80%A6_zu_vermeidende_oder_nur_nach_arztlicher_Rucksprache\"><\/span>... vengti arba vartoti tik pasitarus su gydytoju:<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Smilkalai ir mira:<\/strong> Didel\u0117s doz\u0117s<\/li>\n\n\n\n<li><strong>Raudon\u0117lis \/ \u010diobrelis:<\/strong> Stipriai imunomoduliuojantis<\/li>\n\n\n\n<li><strong>Arbatmed\u017eio aliejus:<\/strong> Imunostimuliatorius<\/li>\n\n\n\n<li><strong>Visos \u017eod\u017eiu gaunamos pajamos<\/strong> terapin\u0117s doz\u0117s<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Fazit\"><\/span>I\u0161vada<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Eterini\u0173 aliej\u0173 ir biologini\u0173 vaist\u0173 s\u0105veika yra ma\u017eai mokslini\u0173 tyrim\u0173 objektas. Teorin\u0117 rizika daugiausia susijusi su padid\u0117jusia imunosupresija ir infekcijos rizika. Vietinis ma\u017eos koncentracijos eterini\u0173 aliej\u0173 naudojimas tikriausiai yra saugus, ta\u010diau bet koks j\u0173 naudojimas tur\u0117t\u0173 b\u016bti aptartas su gydan\u010diu gydytoju. Sergant autoimunin\u0117mis ligomis, kurioms taikomas biologinis gydymas, saugumas yra svarbiausias.<\/p>\n\n\n\n<p><strong>Svarbu:<\/strong> Tai n\u0117ra medicininis patarimas. D\u0117l bet kokio papildomo gydymo autoimunin\u0117ms ligoms gydyti naudojimo b\u016btina individualiai susitarti su specialistu.<\/p>","protected":false},"excerpt":{"rendered":"<p><span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Skaitymo laikas<\/span> <span class=\"rt-time\"> 20<\/span> <span class=\"rt-label rt-postfix\">minut\u0117s<\/span><\/span>Autoimmunerkrankungen und Immunmodulation stehen in direktem Zusammenhang. Wie \u00c4therische \u00d6le immunmodulatorisch wirken, soll nachfolgend sowohl f\u00fcr medizinische Laien verst\u00e4ndlich erkl\u00e4rt, wie f\u00fcr medizinisches Fachpersonal (mittels Studien) dargelegt werden. Vorab noch drei Begriffe, deren Bedeutung gekl\u00e4rt sein soll, um m\u00f6glichen Unklarheiten zu begegnen: Autoimmunit\u00e4t Von Autoimmunit\u00e4t spricht man bei einer krankhaften (pathologischen) Immunantwort des menschlichen Organismus&hellip;&nbsp;<a href=\"https:\/\/csiag.eu\/lt\/blog\/2025\/12\/23\/autoimmunerkrankung-und-immunmodulation-aetherischer-oele\/\" rel=\"bookmark\">Skaityti daugiau \"<span class=\"screen-reader-text\">Autoimunin\u0117s ligos ir eterini\u0173 aliej\u0173 imunomoduliacija<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"[\"title\",\"meta\",\"thumbnail\",\"content\",\"tags\",\"comments\"]","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[3401,1078,354],"tags":[5575,94,5576,5581,5537,117,5538,650,5540,5558,5578,4643,5568,3902,5566,1569,3901,5574,5573,3104,5579,5543,5562,3972,5580,5555,4819,1446,5569,5560,5542,5553,5552,5544,3323,5539,46,98,5559,1896,5548,1568,82,81,3446,5556,5583,3897,4818,4349,5545,5567,5557,5577,5550,1747,5549,5563,5582,1971,5546,5547,5572,5551,3898,5561,4437,31,5564,5571,5541,4648],"class_list":["post-11899","post","type-post","status-publish","format-standard","hentry","category-aetherische-oele","category-medizin","category-medizin-gesundheit","tag-anregend","tag-antikoerper","tag-antiseptisch","tag-aromatisch","tag-autimmunerkrankung","tag-autoantikoerper","tag-autoimmunitaet","tag-bakterien","tag-bakterium","tag-bauchspeicheldruese","tag-beruhigend","tag-blut","tag-bodenbeschaffenheit","tag-chemotyp","tag-chemotypen","tag-colitis-ulcerosa","tag-ct","tag-ct-linalool","tag-ct-thymol","tag-darm","tag-entspannend","tag-entzuendung","tag-entzuendungsstoffe","tag-erntezeitpunkt","tag-gehrin","tag-gelenke","tag-gewebe","tag-haut","tag-hoehenlage","tag-hshioto","tag-humoral","tag-il-1","tag-il-6","tag-immunantwort","tag-immunmodulation","tag-immunsuppression","tag-immunsystem","tag-immunzellen","tag-lupus","tag-lymphe","tag-lymphozyten","tag-morbus-crohn","tag-ms","tag-multiple-sklerose","tag-nase","tag-nervenhuellen","tag-nf-b","tag-olfaktorisch","tag-organe","tag-organismus","tag-pathologisch","tag-pflanzenart","tag-schilddruese","tag-schleimloesend","tag-stimulativ","tag-studien","tag-suppressiv","tag-sutdie","tag-systemisch","tag-t-lymphozyten","tag-t-zelle","tag-t-zellen","tag-thymian","tag-tnf-","tag-topisch","tag-typ-1","tag-uv-strahlung","tag-virus","tag-volltext","tag-wachstumsbedingungen","tag-zell","tag-zellulaer"],"modified_by":"Achim Goerner","_links":{"self":[{"href":"https:\/\/csiag.eu\/lt\/wp-json\/wp\/v2\/posts\/11899","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csiag.eu\/lt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csiag.eu\/lt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csiag.eu\/lt\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csiag.eu\/lt\/wp-json\/wp\/v2\/comments?post=11899"}],"version-history":[{"count":0,"href":"https:\/\/csiag.eu\/lt\/wp-json\/wp\/v2\/posts\/11899\/revisions"}],"wp:attachment":[{"href":"https:\/\/csiag.eu\/lt\/wp-json\/wp\/v2\/media?parent=11899"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csiag.eu\/lt\/wp-json\/wp\/v2\/categories?post=11899"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csiag.eu\/lt\/wp-json\/wp\/v2\/tags?post=11899"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}