{"id":12526,"date":"2026-01-28T10:17:48","date_gmt":"2026-01-28T10:17:48","guid":{"rendered":"https:\/\/csiag.eu\/?p=12526"},"modified":"2026-01-28T12:42:52","modified_gmt":"2026-01-28T12:42:52","slug":"koloidai-saugiai-veiksmingi-ar-ne","status":"publish","type":"post","link":"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/","title":{"rendered":"Koloidai - saugiai veiksmingi ar ne?"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_87_1 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Turinys<\/p>\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Kolloidales_Silber_Ag\" >Koloidinis sidabras (Ag)<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Aktueller_wissenschaftlicher_Stand\" >Dabartin\u0117 mokslin\u0117 pad\u0117tis<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Vorhandene_Studien_und_deren_Limitationen\" >Atlikti tyrimai ir j\u0173 tr\u016bkumai<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Systematische_Reviews_und_Meta-Analysen\" >Sistemin\u0117s ap\u017evalgos ir metaanaliz\u0117s<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Problematik_der_Bioverfugbarkeit\" >Biologinio prieinamumo problema<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Regulatorische_Position\" >Reguliavimo pozicija<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Dokumentierte_Risiken_bei_oraler_Einnahme\" >Dokumentais pagr\u012fsta rizika, susijusi su geriamuoju vartojimu<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Kolloidales_Gold_Au\" >Koloidinis auksas (Au)<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Wissenschaftlicher_Stand\" >Mokslinis statusas<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Kolloidales_Gold_%E2%80%93_Evidenzlage\" >Koloidinis auksas - \u012frodym\u0173 baz\u0117<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Bioverfugbarkeit_und_Pharmakokinetik\" >Biologinis prieinamumas ir farmakokinetika<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#24_Sicherheitsprofil\" >2.4 Saugumo profilis<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Kolloidales_Kupfer_Cu\" >Koloidinis varis (Cu)<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Wissenschaftlicher_Stand-2\" >Mokslinis statusas<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Kolloidales_vs_ionisches_Kupfer\" >Koloidinis ir joninis varis<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Toxizitatsrisiko\" >Toksi\u0161kumo rizika<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Kolloidales_Zink_Zn\" >Koloidinis cinkas (Zn)<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Wissenschaftlicher_Stand-3\" >Mokslinis statusas<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Evidenz_fur_Zink-Supplementierung_nicht_spezifisch_kolloidal\" >\u012erodymai, patvirtinantys cinko papild\u0173 (ne konkre\u010diai koloidinio) vartojim\u0105<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Kolloidales_Zink_spezifisch\" >Specifinis koloidinis cinkas<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Risiken\" >Rizika<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Andere_metallische_Kolloide\" >Kiti metalo koloidai<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Platin_Palladium_andere_Edelmetalle\" >Platina, paladis, kiti taurieji metalai<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Nicht-metallische_Kolloide\" >Nemetaliniai koloidai<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Zusammenfassende_Evidenztabelle\" >Apibendrinta \u012frodym\u0173 lentel\u0117<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-26\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Warum_gibt_es_so_wenig_klinische_Forschung\" >Kod\u0117l atliekama tiek ma\u017eai klinikini\u0173 tyrim\u0173?<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-27\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Strukturelle_Grunde\" >Strukt\u016brin\u0117s prie\u017eastys<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-28\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Was_bedeutet_das_fur_die_Interpretation\" >K\u0105 tai rei\u0161kia ai\u0161kinimui?<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-29\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Praktische_Konzentrationen_in_kommerziellen_Produkten\" >Praktin\u0117 koncentracija komerciniuose produktuose<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-30\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Topische_vs_orale_Anwendung_%E2%80%93_ein_wichtiger_Unterschied\" >Svarbus skirtumas tarp vietinio ir geriamojo vartojimo<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-31\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Belegte_topische_Anwendungen\" >Patikrintas vietinis naudojimas<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-32\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Warum_funktioniert_topisch_aber_nicht_oral\" >Kod\u0117l veikia vietinis, bet ne \u017eodinis?<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-33\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Kritische_Bewertung_von_Anekdoten_und_Erfahrungsberichten\" >Kritinis anekdot\u0173 ir lauko ataskait\u0173 vertinimas<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-34\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Warum_personliche_Berichte_nicht_ausreichen\" >Kod\u0117l nepakanka asmenini\u0173 ataskait\u0173<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-35\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Was_ware_notig_fur_Evidenz\" >Ko reikia \u012frodymams pateikti?<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-36\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Wissenschaftliche_Quellen_fur_weitere_Recherche\" >Moksliniai \u0161altiniai tolesniems tyrimams<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-37\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Fazit\" >I\u0161vada<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-38\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Kernaussagen\" >Pagrindiniai prane\u0161imai<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-39\" href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/#Empfehlungen_aus_wissenschaftlicher_Sicht\" >Mokslin\u0117s rekomendacijos<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Skaitymo laikas<\/span> <span class=\"rt-time\"> 6<\/span> <span class=\"rt-label rt-postfix\">minut\u0117s<\/span><\/span>\n<p class=\"wp-block-paragraph\">\u0160is dokumentas pagr\u012fstas paskelbtais moksliniais tyrimais. Svarbu suprasti, kad klinikini\u0173 \u012frodym\u0173 nebuvimas nerei\u0161kia, kad ka\u017ekas yra neveiksminga, o tik tai, kad nebuvo atlikta pakankamai moksli\u0161kai kontroliuojam\u0173 tyrim\u0173 arba kad ankstesni tyrimai nedav\u0117 ai\u0161ki\u0173 rezultat\u0173.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Visi \u201enam\u0173\u201c generatoriai gamina tik <em>jonizuotas<\/em> Vanduo - ne koloidai! Kadangi nespecialistai neturi laboratorijoje sertifikuotos matavimo technikos (da\u017enai minimi laidumo matuokliai nepateikia joki\u0173 atkuriam\u0173 ir tod\u0117l patikim\u0173 duomen\u0173 apie <em>ppm<\/em> (milijonini\u0173 dali\u0173), visada ne\u017einoma, koki\u0105 \u201edoz\u0119\u201c vartojate. D\u0117l to kyla daugyb\u0117 pavoj\u0173, kuri\u0173 nereik\u0117t\u0173 nuvertinti.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Toliau pateikiama moksli\u0161kai pagr\u012fsta informacija, padedanti geriau orientuotis.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Kolloidales_Silber_Ag\"><\/span>Koloidinis sidabras (Ag)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Aktueller_wissenschaftlicher_Stand\"><\/span>Dabartin\u0117 mokslin\u0117 pad\u0117tis<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u012erodym\u0173 santrauka:<\/strong> Per burn\u0105 vartojamo koloidinio sidabro yra <strong>Klinikini\u0173 tyrim\u0173 n\u0117ra<\/strong>, kurie \u012frodyt\u0173 medicinin\u012f veiksmingum\u0105 gydant ligas, atitinkan\u010dias \u012frodymais pagr\u012fstos medicinos standartus.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Vorhandene_Studien_und_deren_Limitationen\"><\/span>Atlikti tyrimai ir j\u0173 tr\u016bkumai<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>In vitro tyrimai (laboratoriniai tyrimai):<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Daugyb\u0117 laboratorini\u0173 tyrim\u0173 rodo antimikrobines savybes:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Morones et al. (2005)<\/strong> svetain\u0117je <em>Nanotechnologijos<\/em>Sidabro nanodalel\u0117s pasi\u017eymi antibakteriniu poveikiu E. coli, kai j\u0173 koncentracija l\u0105steli\u0173 kult\u016broje yra 10-100 \u03bcg\/ml<\/li>\n\n\n\n<li><strong>Rai ir kt. (2012)<\/strong> svetain\u0117je <em>Taikomoji mikrobiologija ir biotechnologija<\/em>Antimikrobinis aktyvumas prie\u0161 daugeliui atspari\u0173 bakterij\u0173 in vitro<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Svarbus apribojimas:<\/strong> In vitro poveikis negali b\u016bti tiesiogiai perkeltas \u012f \u017emogaus organizm\u0105. Vir\u0161kinimo traktas, pH vert\u0117, baltym\u0173 suri\u0161imas ir kiti veiksniai smarkiai kei\u010dia biologin\u012f prieinamum\u0105.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Bandymai su gyv\u016bnais:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Hadrup ir Lam (2014)<\/strong> svetain\u0117je <em>Reguliacin\u0117 toksikologija ir farmakologija<\/em>Sistemin\u0117 ap\u017evalga - Dauguma tyrim\u0173 su gyv\u016bnais orientuoti \u012f toksi\u0161kum\u0105, o ne \u012f terapin\u012f poveik\u012f<\/li>\n\n\n\n<li>Kai kurie tyrimai su gyv\u016bnais rodo antimikrobin\u012f poveik\u012f, ta\u010diau dozi\u0173 ir s\u0105lyg\u0173 negalima pritaikyti \u017emon\u0117ms.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Tyrimai su \u017emon\u0117mis:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Yra <strong>N\u0117ra paskelbt\u0173 atsitiktini\u0173 im\u010di\u0173, placebu kontroliuojam\u0173 dvigubai akl\u0173 tyrim\u0173 (RCT)<\/strong>, kurie \u012frodo per burn\u0105 vartojamo koloidinio sidabro veiksmingum\u0105 gydant infekcijas ar kitas ligas.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Systematische_Reviews_und_Meta-Analysen\"><\/span>Sistemin\u0117s ap\u017evalgos ir metaanaliz\u0117s<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Cochrane duomen\u0173 baz\u0117 (2023):<\/strong> \u012era\u0161\u0173 apie geriam\u0105j\u012f koloidinio sidabro vartojim\u0105 infekcijoms gydyti n\u0117ra<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Hadrup ir kiti (2018)<\/strong> svetain\u0117je <em>Reguliacin\u0117 toksikologija ir farmakologija<\/em>:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>I\u0161sami sidabro panaudojimo medicinoje ap\u017evalga<\/li>\n\n\n\n<li>I\u0161vada: dokumentais patvirtintas vietinis naudojimas, geriamasis naudojimas nepakankamai i\u0161tirtas<\/li>\n\n\n\n<li>N\u0117ra pakankamai \u012frodym\u0173 apie sistemin\u012f gydom\u0105j\u012f poveik\u012f<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Problematik_der_Bioverfugbarkeit\"><\/span>Biologinio prieinamumo problema<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Kod\u0117l geriamasis vartojimas yra problemi\u0161kas:<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Baltym\u0173 suri\u0161imas:<\/strong> Sidabro jonai vir\u0161kinamajame trakte jungiasi su baltymais ir chlorido jonais<\/li>\n\n\n\n<li><strong>AgCl susidarymas:<\/strong> Skrandyje susidaro blogai tirpus sidabro chloridas<\/li>\n\n\n\n<li><strong>Ma\u017ea absorbcija:<\/strong> Tik nedidel\u0117 dalis patenka \u012f krauj\u0105<\/li>\n\n\n\n<li><strong>Greitas pa\u0161alinimas:<\/strong> Apie tul\u017e\u012f ir inkstus<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Farmakokinetiniai tyrimai:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Loeschner et al. (2011)<\/strong> svetain\u0117je <em>Daleli\u0173 ir skaidul\u0173 toksikologija<\/em>: Per burn\u0105 suvartot\u0173 sidabro nanodaleli\u0173 pasiskirstymo \u017eiurk\u0117ms tyrimas - ma\u017eas sisteminis biologinis prieinamumas<\/li>\n\n\n\n<li><strong>Van der Zande et al. (2012)<\/strong> svetain\u0117je <em>ACS Nano<\/em>Sidabro nanodaleli\u0173 absorbcija &lt;1% geriamosios doz\u0117s<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Regulatorische_Position\"><\/span>Reguliavimo pozicija<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>FDA (JAV):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Koloidinis sidabras priskiriamas prie \u201enesaugi\u0173 ir neveiksming\u0173\u201c medicininiam naudojimui.<\/li>\n\n\n\n<li>Draudimas teikti medicininius reikalavimus nuo 1999 m.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>EMA (Europa):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>N\u0117ra leid\u017eiam\u0173 geriam\u0173j\u0173 sidabro preparat\u0173 sistemin\u0117ms infekcijoms gydyti<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>BfR (Vokietija):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u012esp\u0117jimas d\u0117l nekontroliuojamo suvartojimo<\/li>\n\n\n\n<li>Terapiniai teiginiai neturi mokslinio pagrindo<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Dokumentierte_Risiken_bei_oraler_Einnahme\"><\/span>Dokumentais pagr\u012fsta rizika, susijusi su geriamuoju vartojimu<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Argyrie:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Wadhera ir Fung (2005)<\/strong> svetain\u0117je <em>Amerikos klinikin\u0117s dermatologijos \u017eurnalas<\/em>: Argirijos atvej\u0173 po geriamojo sidabro suvartojimo dokumentacija<\/li>\n\n\n\n<li>Negr\u012f\u017etamas m\u0117lynai pilkas odos spalvos pakitimas<\/li>\n\n\n\n<li>Jau galima vartoti 1-5 g sidabro kumuliacines dozes<\/li>\n\n\n\n<li><strong>Skai\u010diavimo pavyzdys:<\/strong> 10 ppm ir 50 ml per par\u0105 = 0,5 mg per par\u0105 \u2192 kritinis kaupimasis galimas po 5-10 met\u0173<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Kiti u\u017efiksuoti \u0161alutiniai poveikiai:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Neurologiniai simptomai (reti)<\/li>\n\n\n\n<li>S\u0105veika su vaistais (antibiotikais, tiroksinu)<\/li>\n\n\n\n<li>Galimi \u017earnyno floros poky\u010diai<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Gulbranson ir kiti (2000)<\/strong> svetain\u0117je <em>Journal of Toxicology<\/em>\u0160alutinio poveikio po ilgalaikio geriamojo vartojimo atvej\u0173 apra\u0161ymai<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Kolloidales_Gold_Au\"><\/span>Koloidinis auksas (Au)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wissenschaftlicher_Stand\"><\/span>Mokslinis statusas<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Medicininiu po\u017ei\u016briu pripa\u017eintos programos:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Aukso junginiai (ne koloidinis auksas) naudojami terapijoje:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Auranofinas ir aukso natrio tiomalatas:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Patvirtinti vaistai nuo reumatoidinio artrito<\/li>\n\n\n\n<li><strong>Finkel\u0161teinas ir kiti (1976)<\/strong> svetain\u0117je <em>Vidaus medicinos metra\u0161tis<\/em>: Klinikiniai aukso pagrindo antireumatini\u0173 vaist\u0173 tyrimai<\/li>\n\n\n\n<li><strong>Svarbu:<\/strong> Tai apibr\u0117\u017eti cheminiai junginiai, o ne koloidin\u0117s suspensijos.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Kolloidales_Gold_%E2%80%93_Evidenzlage\"><\/span>Koloidinis auksas - \u012frodym\u0173 baz\u0117<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Turimi moksliniai tyrimai:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Atsitiktiniai pasteb\u0117jimai:<\/strong> Keletas istorini\u0173 nat\u016bropatijos prane\u0161im\u0173<\/li>\n\n\n\n<li><strong>In vitro:<\/strong> Aukso nanodalel\u0117s pasi\u017eymi prie\u0161u\u017edegimin\u0117mis savyb\u0117mis l\u0105steli\u0173 kult\u016brose<\/li>\n\n\n\n<li><strong>Tyrimai su \u017emon\u0117mis:<\/strong> N\u0117ra paskelbt\u0173 RCT apie per burn\u0105 vartojam\u0105 koloidin\u012f auks\u0105<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Brown et al. (2010)<\/strong> svetain\u0117je <em>Nanomedicina<\/em>Aukso nanodaleli\u0173 medicinoje ap\u017evalga - daugiausia d\u0117mesio skiriama vaist\u0173 perdavimui ir diagnostikai, o ne tiesioginiam gydomajam poveikiui geriant<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Bioverfugbarkeit_und_Pharmakokinetik\"><\/span>Biologinis prieinamumas ir farmakokinetika<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u012esisavinimas:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Aukso nanodalel\u0117s sunkiai absorbuojamos vir\u0161kinimo trakte<\/li>\n\n\n\n<li><strong>Hillyer ir Albrecht (2001)<\/strong> svetain\u0117je <em>Farmacijos moksl\u0173 \u017eurnalas<\/em>&lt;1% nanodaleli\u0173 geriamasis biologinis prieinamumas<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Terapin\u0117 doz\u0117 nenustatyta<\/strong> koloidinio aukso, vartojamo per burn\u0105<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"24_Sicherheitsprofil\"><\/span>2.4 Saugumo profilis<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Paprastai priskiriamas saugesni\u0173 u\u017e sidabr\u0105 kategorijai:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>N\u0117ra kaupimosi rizikos, kaip sidabro atveju (n\u0117ra \u201eauksoz\u0117s\u201c)<\/li>\n\n\n\n<li>Ma\u017eas toksi\u0161kumas esant tipinei koncentracijai<\/li>\n\n\n\n<li>Ta\u010diau taip pat n\u0117ra \u012frodytas poveikis, kai vartojama per burn\u0105<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Kolloidales_Kupfer_Cu\"><\/span>Koloidinis varis (Cu)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wissenschaftlicher_Stand-2\"><\/span>Mokslinis statusas<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Varis - esminis mikroelementas:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Varis yra b\u016btina maistin\u0117 med\u017eiaga (RPN: 0,9 mg per par\u0105 suaugusiesiems), ta\u010diau:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u012eprastin\u0117 mityba patenkina poreikius<\/li>\n\n\n\n<li>Papild\u0173 vartojimas prasmingas tik tada, kai yra \u012frodytas j\u0173 tr\u016bkumas.<\/li>\n\n\n\n<li><strong>Turnlund ir kiti (1998)<\/strong> svetain\u0117je <em>Amerikos klinikin\u0117s mitybos \u017eurnalas<\/em>: Vario homeostaz\u0117s tyrimai<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Kolloidales_vs_ionisches_Kupfer\"><\/span>Koloidinis ir joninis varis<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Diferenciacijos problema:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Daugelyje \u201ekoloidinio\u201c vario produkt\u0173 daugiausia yra joninio vario (Cu\u00b2\u207a).<\/li>\n\n\n\n<li>Tikrosios koloidin\u0117s dalel\u0117s (Cu\u2070) yra nestabilios ir greitai oksiduojasi<\/li>\n\n\n\n<li>N\u0117ra mokslin\u0117s literat\u016bros apie medicinin\u012f poveik\u012f, kur\u012f turi specialiai per burn\u0105 vartojamas koloidinis varis.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Toxizitatsrisiko\"><\/span>Toksi\u0161kumo rizika<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Varis turi siaur\u0105 terapin\u012f lang\u0105:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Perdozavimas:<\/strong> &gt;10 mg per par\u0105 gali sukelti toksi\u0161kum\u0105<\/li>\n\n\n\n<li><strong>Vilsono liga:<\/strong> Genetinis vario kaupimosi sutrikimas - draud\u017eiama<\/li>\n\n\n\n<li><strong>Vir\u0161kinimo trakto simptomai:<\/strong> Pykinimas, v\u0117mimas vartojant didesnes dozes<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Medicinos institutas (2001)<\/strong>Toleruotina vir\u0161utin\u0117 leistina doz\u0117 = 10 mg per dien\u0105<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Kolloidales_Zink_Zn\"><\/span>Koloidinis cinkas (Zn)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wissenschaftlicher_Stand-3\"><\/span>Mokslinis statusas<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Cinkas - esminis mikroelementas:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Gerai \u012frodyta, kad jis svarbus imuninei sistemai (RPN: 11 mg per dien\u0105 vyrams, 8 mg per dien\u0105 moterims)<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Evidenz_fur_Zink-Supplementierung_nicht_spezifisch_kolloidal\"><\/span>\u012erodymai, patvirtinantys cinko papild\u0173 (ne konkre\u010diai koloidinio) vartojim\u0105<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Per\u0161alimo ligos:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Hemil\u00e4 et al. (2017)<\/strong> svetain\u0117je <em>Cochrane duomen\u0173 baz\u0117<\/em>: Cinko pastili\u0173 nuo per\u0161alimo metaanaliz\u0117\n<ul class=\"wp-block-list\">\n<li>Rezultatas: \u0161al\u010dio trukm\u0117 sutrump\u0117ja ma\u017edaug 33%<\/li>\n\n\n\n<li><strong>Svarbu:<\/strong> Tyrimuose naudotas cinko acetatas arba gliukonatas, o ne koloidinis cinkas<\/li>\n\n\n\n<li>Dozavimas: 75-100 mg per dien\u0105 per\u0161alimo metu<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Imunin\u0117 funkcija:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Prasad (2008)<\/strong> svetain\u0117je <em>Journal of Trace Elements in Medicine and Biology<\/em>Cinkas gerina imunin\u012f atsak\u0105, jei jo tr\u016bksta<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Kolloidales_Zink_spezifisch\"><\/span>Specifinis koloidinis cinkas<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u012erodym\u0173 tr\u016bkumas:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>N\u0117ra paskelbt\u0173 tyrim\u0173, kuriuose b\u016bt\u0173 lyginama koloidinio cinko forma su kitomis formomis<\/li>\n\n\n\n<li>N\u0117ra \u012frodym\u0173, kad koloidinis cinkas turi prana\u0161um\u0173 prie\u0161 \u012fprastus cinko papildus<\/li>\n\n\n\n<li>Biologinis prieinamumas tikriausiai pana\u0161us arba blogesnis nei \u012fprast\u0173 form\u0173 (citrato, gliukonato)<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Risiken\"><\/span>Rizika<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Perdozavimas:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Vario absorbcijos trikd\u017eiai, kai vartojama &gt;50 mg per par\u0105 ilg\u0105 laik\u0105<\/li>\n\n\n\n<li>Vir\u0161kinimo trakto sutrikimai<\/li>\n\n\n\n<li>Toleruotina vir\u0161utin\u0117 riba: 40 mg per dien\u0105 (Medicinos institutas)<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Andere_metallische_Kolloide\"><\/span>Kiti metalo koloidai<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Platin_Palladium_andere_Edelmetalle\"><\/span>Platina, paladis, kiti taurieji metalai<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Mokslin\u0117 literat\u016bra:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Beveik n\u0117ra paskelbt\u0173 tyrim\u0173 su \u017emon\u0117mis apie geriam\u0105j\u012f vartojim\u0105<\/li>\n\n\n\n<li>Kai kurie platinos nanodaleli\u0173 antioksidacini\u0173 savybi\u0173 in vitro tyrimai<\/li>\n\n\n\n<li><strong>Nenustatytas terapinis pritaikymas<\/strong> vartojant per burn\u0105<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Nicht-metallische_Kolloide\"><\/span>Nemetaliniai koloidai<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Miceliniai vitamin\u0173 preparatai:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Tai teis\u0117tas koloidin\u0117s technologijos pritaikymas farmacijoje:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Goncalves ir kiti (2021)<\/strong> svetain\u0117je <em>Maistin\u0117s med\u017eiagos<\/em>Geresnis riebaluose tirpi\u0173 vitamin\u0173 biologinis prieinamumas naudojant miceles<\/li>\n\n\n\n<li>Klini\u0161kai svarbus vartojimas malabsorbcijos atveju<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Zusammenfassende_Evidenztabelle\"><\/span>Apibendrinta \u012frodym\u0173 lentel\u0117<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>Koloidai<\/th><th>RCT \u012frodymai<\/th><th>In vitro aktyvumas<\/th><th>Peroralinis biologinis prieinamumas<\/th><th>Leid\u017eiama vartoti medicinos tikslais per burn\u0105<\/th><th>Saugumo problemos<\/th><\/tr><\/thead><tbody><tr><td><strong>sidabras<\/strong><\/td><td>N\u0117ra<\/td><td>Auk\u0161tas (antimikrobinis)<\/td><td>Labai ma\u017eas (&lt;1%)<\/td><td>N\u0117ra<\/td><td>Didelis (argirija)<\/td><\/tr><tr><td><strong>Auksinis<\/strong><\/td><td>N\u0117ra<\/td><td>Priemon\u0117 (prie\u0161u\u017edegimin\u0117)<\/td><td>Labai ma\u017eas (&lt;1%)<\/td><td>N\u0117ra (koloidin\u0117 forma)<\/td><td>\u017demas<\/td><\/tr><tr><td><strong>Vario<\/strong><\/td><td>N\u0117ra (kaip koloido)<\/td><td>NETAIKOMA<\/td><td>Ne\u017einomas<\/td><td>Tik tuo atveju, jei \u012frodytas defektas<\/td><td>Vidutini\u0161kai didelis (toksi\u0161kumas)<\/td><\/tr><tr><td><strong>Cinkas<\/strong><\/td><td>Taip (kitos formos)<\/td><td>NETAIKOMA<\/td><td>Tikriausiai ma\u017eai<\/td><td>Taip (kaip druska, ne koloidas)<\/td><td>Priemon\u0117 (perdozavus)<\/td><\/tr><tr><td><strong>Platina ir (arba) kita<\/strong><\/td><td>N\u0117ra<\/td><td>Silpnas<\/td><td>Ne\u017einomas<\/td><td>N\u0117ra<\/td><td>Ne\u017einomas<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Warum_gibt_es_so_wenig_klinische_Forschung\"><\/span>Kod\u0117l atliekama tiek ma\u017eai klinikini\u0173 tyrim\u0173?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Strukturelle_Grunde\"><\/span>Strukt\u016brin\u0117s prie\u017eastys<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Patentabilumo nebuvimas:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Gamtiniai elementai negali b\u016bti patentuojami<\/li>\n\n\n\n<li>N\u0117ra finansini\u0173 paskat\u0173 brangiems klinikiniams tyrimams (I-III faz\u0117s kainuoja daugiau nei 100 mln. eur\u0173).<\/li>\n\n\n\n<li>Farmacijos bendrov\u0117s neinvestuoja be i\u0161imtini\u0173 teisi\u0173<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Reguliavimo kli\u016btys:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Neai\u0161ki klasifikacija (maisto papildas ir vaistas)<\/li>\n\n\n\n<li>Standartizavimo problemos (skirtingas daleli\u0173 dydis, koncentracija)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Metodologiniai i\u0161\u0161\u016bkiai:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Sud\u0117tingas apakinimas (spalva!)<\/li>\n\n\n\n<li>Tiriamosios med\u017eiagos kokyb\u0117s kontrol\u0117<\/li>\n\n\n\n<li>Reikalingi ilgalaikiai saugumo tyrimai<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Was_bedeutet_das_fur_die_Interpretation\"><\/span>K\u0105 tai rei\u0161kia ai\u0161kinimui?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u012erodym\u0173 nebuvimas \u2260 \u012erodym\u0173 nebuvimo faktas<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Tai, kad n\u0117ra RCT, neb\u016btinai rei\u0161kia, kad koloidiniai metalai yra neveiksmingi. Tai rei\u0161kia, kad:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Neturime moksli\u0161kai patikimo veiksmingumo patvirtinimo<\/li>\n\n\n\n<li>Negalime pateikti \u012frodymais pagr\u012fst\u0173 dozavimo rekomendacij\u0173<\/li>\n\n\n\n<li>Ilgalaikis saugumas nebuvo sistemingai tiriamas<\/li>\n<\/ol>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Praktische_Konzentrationen_in_kommerziellen_Produkten\"><\/span>Praktin\u0117 koncentracija komerciniuose produktuose<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Tipi\u0161ka koncentracija rinkoje:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Koloidinis sidabras:<\/strong> 5-50 ppm (kai kurie iki 500 ppm)<\/li>\n\n\n\n<li><strong>Koloidinis auksas:<\/strong> 10-30 ppm<\/li>\n\n\n\n<li><strong>Kiti metalai:<\/strong> 10-50 ppm<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u012eprastin\u0117 dozavimo informacija (gamintojo nurodymai, nepagr\u012fsti \u012frodymais):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>1-3 arbatiniai \u0161auk\u0161teliai (5-15 ml) per dien\u0105<\/li>\n\n\n\n<li>10 ppm = 0,05-0,15 mg metalo per dien\u0105<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Mokslinis \u0161i\u0173 dozi\u0173 \u012fvertinimas:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Sidabrui ir auksui: Tikriausiai per ma\u017eas sisteminiam poveikiui ir prastas biologinis prieinamumas.<\/li>\n\n\n\n<li>Svarbiausi\u0173 mikroelement\u0173 (Zn, Cu): \u017dymiai ma\u017eiau nei RPN.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Topische_vs_orale_Anwendung_%E2%80%93_ein_wichtiger_Unterschied\"><\/span>Svarbus skirtumas tarp vietinio ir geriamojo vartojimo<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Belegte_topische_Anwendungen\"><\/span>Patikrintas vietinis naudojimas<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Sidabras \u017eaizdoms gydyti:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Vermeulen et al. (2007)<\/strong> svetain\u0117je <em>Cochrane duomen\u0173 baz\u0117<\/em>Sistemin\u0117 sidabro turin\u010di\u0173 \u017eaizd\u0173 tvars\u010di\u0173 ap\u017evalga<\/li>\n\n\n\n<li><strong>Rezultatas:<\/strong> Vidutinio veiksmingumo \u012frodymai infekuotoms \u017eaizdoms<\/li>\n\n\n\n<li><strong>Mechanizmas:<\/strong> Tiesioginis kontaktas su bakterijomis, nereikia sistemin\u0117s absorbcijos<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>koncentracijos vieti\u0161kai:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Medicininiai \u017eaizd\u0173 tvars\u010diai: 50-100 ppm sidabro<\/li>\n\n\n\n<li>Tiesioginis antimikrobinis kontaktas<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Warum_funktioniert_topisch_aber_nicht_oral\"><\/span>Kod\u0117l veikia vietinis, bet ne \u017eodinis?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Lemiami skirtumai:<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Tiesioginis kontaktas:<\/strong> Sidabro jonai turi tiesiogin\u012f vietin\u012f poveik\u012f bakterijoms<\/li>\n\n\n\n<li><strong>N\u0117ra GI inaktyvacijos:<\/strong> N\u0117ra skrand\u017eio pH, nesusij\u0119s su baltymais<\/li>\n\n\n\n<li><strong>Vietos koncentracija:<\/strong> Galima didel\u0117 koncentracija veikimo vietoje<\/li>\n\n\n\n<li><strong>Biologinis prieinamumas nesvarbus:<\/strong> Sistemin\u0117 absorbcija neb\u016btina<\/li>\n<\/ol>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Kritische_Bewertung_von_Anekdoten_und_Erfahrungsberichten\"><\/span>Kritinis anekdot\u0173 ir lauko ataskait\u0173 vertinimas<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Warum_personliche_Berichte_nicht_ausreichen\"><\/span>Kod\u0117l nepakanka asmenini\u0173 ataskait\u0173<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Placebo poveikis:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Esant subjektyviems simptomams (nuovargiui, skausmui), placebo atsako da\u017enis da\u017enai yra 30-40%<\/li>\n\n\n\n<li><strong>Finniss et al. (2010)<\/strong> svetain\u0117je <em>Lancet<\/em>: Placebo poveikio ap\u017evalga<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Spontani\u0161ka remisija:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Daugelis lig\u0173 (per\u0161alimas, lengvos infekcijos) pasveiksta savaime.<\/li>\n\n\n\n<li>Laiko ry\u0161ys \u2260 Prie\u017eastingumas<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Patvirtinimo \u0161ali\u0161kumas:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Polinkis prisiminti ir prane\u0161ti apie teigiam\u0105 patirt\u012f<\/li>\n\n\n\n<li>Neigiama patirtis dokumentuojama re\u010diau<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Publikacij\u0173 tendencingumas:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Teigiami rezultatai da\u017eniau skelbiami vie\u0161ai nei neigiami.<\/li>\n\n\n\n<li>Daug nedideli\u0173 tyrim\u0173 su neigiamais rezultatais lieka nepaskelbti<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Was_ware_notig_fur_Evidenz\"><\/span>Ko reikia \u012frodymams pateikti?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Atsitiktini\u0173 im\u010di\u0173, placebu kontroliuojami, dvigubai akli tyrimai su:<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Pakankamas dalyvi\u0173 skai\u010dius (galios analiz\u0117)<\/li>\n\n\n\n<li>Objektyv\u016bs galutiniai rodikliai (ne tik subjektyv\u016bs simptomai)<\/li>\n\n\n\n<li>Standartizuotas produktas (nustatytas daleli\u0173 dydis, koncentracija)<\/li>\n\n\n\n<li>Recenzuotas leidinys<\/li>\n\n\n\n<li>Nepriklausom\u0173 tyr\u0117j\u0173 atliktas pakartojimas<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0160iuo metu toki\u0173 tyrim\u0173, susijusi\u0173 su per burn\u0105 vartojamais metalo koloidais, n\u0117ra atlikta.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wissenschaftliche_Quellen_fur_weitere_Recherche\"><\/span>Moksliniai \u0161altiniai tolesniems tyrimams<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Rekomenduojamos duomen\u0173 baz\u0117s:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>PubMed\/MEDLINE:<\/strong> pubmed.ncbi.nlm.nih.gov\n<ul class=\"wp-block-list\">\n<li>Paie\u0161kos terminai: \u201ecolloidal silver oral\u201c, \u201esilver nanoparticles ingestion\u201c, \u201egold nanoparticles oral bioavailability\u201c.\u201c<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Cochrane biblioteka:<\/strong> cochranelibrary.com\n<ul class=\"wp-block-list\">\n<li>Sistemin\u0117s ap\u017evalgos ir metaanaliz\u0117s (auksinis standartas)<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Mokslo \u017einiatinklis:<\/strong> webofscience.com\n<ul class=\"wp-block-list\">\n<li>Citavimo analiz\u0117, poveikio veiksniai<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Svarb\u016bs ap\u017evalginiai straipsniai:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Hadrup ir Lam (2014):<\/strong> \u201eSidabro jon\u0173, sidabro nanodaleli\u0173 ir koloidinio sidabro oralinis toksi\u0161kumas - ap\u017evalga\u201c in <em>Reguliacin\u0117 toksikologija ir farmakologija<\/em><\/li>\n\n\n\n<li><strong>Fung &amp; Bowen (1996):<\/strong> \u201eMedicinin\u0117ms indikacijoms skirti sidabro gaminiai: rizikos ir naudos vertinimas\u201c, in <em>Journal of Toxicology<\/em><\/li>\n\n\n\n<li><strong>Lansdown (2006):<\/strong> \u201eSidabras sveikatos prie\u017ei\u016broje: antimikrobinis poveikis ir naudojimo sauga\u201c in <em>Biofunkcin\u0117 tekstil\u0117 ir oda<\/em><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Fazit\"><\/span>I\u0161vada<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Kernaussagen\"><\/span>Pagrindiniai prane\u0161imai<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>N\u0117ra patikim\u0173 klinikini\u0173 tyrim\u0173, susijusi\u0173 su metal\u0173 koloid\u0173 (ypa\u010d sidabro ir aukso) vartojimu per burn\u0105.<\/strong>, kurie \u012frodyt\u0173 medicinin\u012f veiksmingum\u0105 pagal \u012frodymais pagr\u012fstos medicinos standartus.<\/li>\n\n\n\n<li><strong>In vitro aktyvumas (laboratorijoje) yra gerai dokumentuotas<\/strong>, ypa\u010d sidabro, bet <strong>Neperkeliama \u012f geriam\u0105j\u012f vartojim\u0105<\/strong> d\u0117l itin ma\u017eo biologinio prieinamumo.<\/li>\n\n\n\n<li><strong>Vietinis sidabro naudojimas<\/strong> gydant \u017eaizdas yra <strong>Moksli\u0161kai \u012frodyta<\/strong> - \u010cia jis veikia per tiesiogin\u012f kontakt\u0105.<\/li>\n\n\n\n<li><strong>Su ilgalaikiu geriamuoju vartojimu susijusi rizika yra dokumentais pagr\u012fsta<\/strong>, ypa\u010d sidabro argirija.<\/li>\n\n\n\n<li><strong>\u012erodym\u0173 tr\u016bkumas vis\u0173 pirma yra mokslini\u0173 tyrim\u0173 problema<\/strong>, Tai neb\u016btinai yra neveiksmingumo \u012frodymas - papras\u010diausiai tr\u016bksta auk\u0161tos kokyb\u0117s tyrim\u0173.<\/li>\n<\/ol>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Empfehlungen_aus_wissenschaftlicher_Sicht\"><\/span>Mokslin\u0117s rekomendacijos<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Jei norite gerti metalo koloidus:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Pasikonsultuokite su gydytoju, ypa\u010d jei sergate kokiomis nors ligomis.<\/li>\n\n\n\n<li>\u017dinokite, kad turite <strong>nepagr\u012fsti \u012frodymais.<\/strong> Pasirinkite gydym\u0105<\/li>\n\n\n\n<li>Steb\u0117ti galim\u0105 \u0161alutin\u012f poveik\u012f<\/li>\n\n\n\n<li>Nesitik\u0117kite \u201estebuklingo efekto\u201c<\/li>\n\n\n\n<li>Nepakei\u010dia \u012frodymais pagr\u012fsto gydymo<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Svarbiausi\u0173 mikroelement\u0173 (cinko, vario):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u012eprastiniai preparatai yra geriau i\u0161tirti ir, tik\u0117tina, labiau biologi\u0161kai aktyv\u016bs.<\/li>\n\n\n\n<li>Jei \u012ftariate, kad tr\u016bksta kraujo, pirmiausia nustatykite jo kiek\u012f kraujyje.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Moksli\u0161kai s\u0105\u017einingas atsakymas yra toks:<\/strong> Tiksliai to ne\u017einome, nes reikalingi tyrimai niekada nebuvo atlikti. Turimi duomenys rodo, kad geriamasis biologinis prieinamumas yra per ma\u017eas sisteminiam gydomajam poveikiui, ta\u010diau tr\u016bksta galutini\u0173 \u012frodym\u0173, t. y. RCT.<\/p>","protected":false},"excerpt":{"rendered":"<p><span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Skaitymo laikas<\/span> <span class=\"rt-time\"> 6<\/span> <span class=\"rt-label rt-postfix\">minut\u0117s<\/span><\/span>Diese Abhandlung basiert auf ver\u00f6ffentlichten wissenschaftlichen Studien. Es ist entscheidend zu verstehen, dass das Fehlen klinischer Evidenz nicht bedeutet, dass etwas unwirksam ist, sondern lediglich, dass keine ausreichenden wissenschaftlich kontrollierten Studien durchgef\u00fchrt wurden oder bisherige Studien keine eindeutigen Ergebnisse erbracht haben. Alle &#8222;Heim&#8220;-Generatoren erzeugen nur ionisiertes Wasser &#8211; keine Kolloide! Mangels f\u00fcr Laien verf\u00fcgbare laborzertifizierter&hellip;&nbsp;<a href=\"https:\/\/csiag.eu\/lt\/blog\/2026\/01\/28\/kolloide-sicher-wirksam-oder-nicht\/\" rel=\"bookmark\">Skaityti daugiau \"<span class=\"screen-reader-text\">Koloidai - saugiai veiksmingi ar ne?<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-12526","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"modified_by":"Achim Goerner","_links":{"self":[{"href":"https:\/\/csiag.eu\/lt\/wp-json\/wp\/v2\/posts\/12526","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csiag.eu\/lt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csiag.eu\/lt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csiag.eu\/lt\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csiag.eu\/lt\/wp-json\/wp\/v2\/comments?post=12526"}],"version-history":[{"count":0,"href":"https:\/\/csiag.eu\/lt\/wp-json\/wp\/v2\/posts\/12526\/revisions"}],"wp:attachment":[{"href":"https:\/\/csiag.eu\/lt\/wp-json\/wp\/v2\/media?parent=12526"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csiag.eu\/lt\/wp-json\/wp\/v2\/categories?post=12526"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csiag.eu\/lt\/wp-json\/wp\/v2\/tags?post=12526"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}