{"id":10036,"date":"2025-06-02T19:05:44","date_gmt":"2025-06-02T19:05:44","guid":{"rendered":"https:\/\/csiag.eu\/?p=10036"},"modified":"2025-06-03T20:37:17","modified_gmt":"2025-06-03T20:37:17","slug":"lnp-toksiskums-atkariba-no-tapu-kedes-garuma","status":"publish","type":"post","link":"https:\/\/csiag.eu\/lv\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/","title":{"rendered":"LNP toksicit\u0101te atkar\u012bb\u0101 no PEG \u0137\u0113des garuma"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_86 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Satura r\u0101d\u012bt\u0101js<\/p>\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/csiag.eu\/lv\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Welche_LNPs_wurden_verwendet\" >K\u0101di LNP tika izmantoti?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/csiag.eu\/lv\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Toxizitat_wurde_nicht_durch_Studien_uberpruft\" >Toksicit\u0101te nav p\u0101rbaud\u012bta p\u0113t\u012bjumos.<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/csiag.eu\/lv\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Akkumulation_in_der_Leber\" >Uzkr\u0101\u0161an\u0101s akn\u0101s<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/csiag.eu\/lv\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Der_Weg_in_die_Leber_und_die_Lange_der_Kette\" >Ce\u013c\u0161 uz akn\u0101m un \u0137\u0113des garums<\/a><\/li><\/ul><\/nav><\/div>\n<span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Las\u012b\u0161anas laiks<\/span> <span class=\"rt-time\"> 2<\/span> <span class=\"rt-label rt-postfix\">protokols<\/span><\/span>\n<p class=\"wp-block-paragraph\">Jo \u012bs\u0101ka ir PEG (polietil\u0113nglikola) \u0137\u0113de, jo liel\u0101ks ir LNP toksiskums. BioNTech to skaidro sav\u0101 <a href=\"https:\/\/www.mdpi.com\/2227-9059\/9\/5\/530\" target=\"_blank\" rel=\"noreferrer noopener\">Publik\u0101cija<\/a> \"LNP-mRNA pielietojums bez im\u016bnterapijas: maksim\u0101la efektivit\u0101te un dro\u0161\u012bba\" no 10.05.2021., lai gan formul\u0113ts nedaudz cit\u0101di: \"Maksim\u0101la efektivit\u0101te\".<br>Toksiskuma pamat\u0101 ir tas, ka visi tr\u012bs joniz\u0113jamie katjonu lip\u012bdi nav biolo\u0123iski no\u0101rd\u0101mi un to neizb\u0113gama uzkr\u0101\u0161an\u0101s organism\u0101 rada citotoksiskas sekas.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Welche_LNPs_wurden_verwendet\"><\/span>K\u0101di LNP tika izmantoti?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Pfizer<\/em> \/ <em>BioNTech<\/em> - BNT162b2 - <a href=\"https:\/\/www.echelon-inc.com\/product\/alc-0315\/\" target=\"_blank\" rel=\"noreferrer noopener\">ALC-0315<\/a> (joniz\u0113jams) un <a href=\"https:\/\/www.echelon-inc.com\/product\/alc-0159\/\" target=\"_blank\" rel=\"noreferrer noopener\">ALC-0159<\/a> (ar PEG)<br><em>Moderna<\/em> - <a href=\"https:\/\/www.echelon-inc.com\/product\/sm-102\/\" target=\"_blank\" rel=\"noreferrer noopener\">SM-102<\/a> (joniz\u0113jams) un <a href=\"https:\/\/www.echelon-inc.com\/product\/dmg-peg-2000\/\" target=\"_blank\" rel=\"noreferrer noopener\">PEG2000-DMG<\/a> (ar PEG)<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"562\" src=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-1024x562.png\" alt=\"\" class=\"wp-image-10045\" srcset=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-1024x562.png 1024w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-300x165.png 300w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-768x421.png 768w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-18x10.png 18w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image.png 1456w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">Visiem iepriek\u0161 min\u0113tajiem lip\u012bdiem ra\u017eot\u0101ji (piem. <a href=\"https:\/\/www.echelon-inc.com\/product\/alc-0315\/#tab-description\" target=\"_blank\" rel=\"noreferrer noopener\">Echelon Biosciences<\/a>) \"... \u0160is ir rea\u0123enta klases produkts, paredz\u0113ts tikai p\u0113tnieciskai lieto\u0161anai.\"<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Toxizitat_wurde_nicht_durch_Studien_uberpruft\"><\/span>Toksicit\u0101te nav p\u0101rbaud\u012bta p\u0113t\u012bjumos.<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Saska\u0146\u0101 ar <a href=\"https:\/\/www.tga.gov.au\/sites\/default\/files\/foi-2389-06.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Publik\u0101cija<\/a> Austr\u0101lijas vald\u012bbas - Vesel\u012bbas ministrijas 2021. gada janv\u0101ra \"Nekl\u012bnisko nov\u0113rt\u0113jumu zi\u0146ojuma BNT 162b2 mRNA COVID-19 vakc\u012bna COMIRNATY\u2122\" 11. lappus\u0113 var las\u012bt: \"LNP prepar\u0101ta vai jauno pal\u012bgvielu toksicit\u0101te atsevi\u0161\u0137i netika \u012bpa\u0161i p\u0113t\u012bta.\"<br>Citiem v\u0101rdiem sakot, nav veikti iepriek\u0161 min\u0113to jauno LNP pal\u012bgvielu lieto\u0161anas un iedarb\u012bbas toksicit\u0101tes p\u0113t\u012bjumi.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Akkumulation_in_der_Leber\"><\/span>Uzkr\u0101\u0161an\u0101s akn\u0101s<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Daudzas z\u0101les da\u013c\u0113ji vai piln\u012bb\u0101 metaboliz\u0113jas akn\u0101s un non\u0101k asinsrit\u0113. Iepriek\u0161 min\u0113t\u0101 pal\u012bgviela ALC-315 ar\u012b uzkr\u0101jas akn\u0101s, k\u0101 redzams no tabulas. <a href=\"https:\/\/www.judicialwatch.org\/wp-content\/uploads\/2022\/03\/JW-v-HHS-prod-3-02418.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Da\u013c\u0113ja atbilde uz jaut\u0101jumu Nr. 2021-4379<\/a> saska\u0146\u0101 ar Inform\u0101cijas br\u012bv\u012bbas likumu (FOIA), par kuru ir iesniegta s\u016bdz\u012bba liet\u0101 Judicial Watch, Inc. v. U.S. Department of Health and Human Services (21-cv-2418), kas pa\u0161laik tiek izskat\u012bta ASV Kolumbijas apgabala ties\u0101, 16. lpp. no 466. lpp:<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"542\" src=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-1024x542.png\" alt=\"\" class=\"wp-image-10054\" srcset=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-1024x542.png 1024w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-300x159.png 300w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-768x407.png 768w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-18x10.png 18w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3.png 1212w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Min\u0113ts ar\u012b iepriek\u0161 min\u0113t\u0101 zi\u0146ojuma 45. lappus\u0113. <a href=\"https:\/\/www.tga.gov.au\/sites\/default\/files\/foi-2389-06.pdf\" target=\"_blank\" rel=\"noopener\">Zi\u0146ojumi<\/a>:<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"55\" src=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-1024x55.png\" alt=\"\" class=\"wp-image-10060\" srcset=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-1024x55.png 1024w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-300x16.png 300w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-768x42.png 768w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-18x1.png 18w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4.png 1218w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">46. lappus\u0113, pamatojoties uz in vitro eksperimentiem, ir izkl\u0101st\u012bts t\u012bri teor\u0113tiski hipot\u0113tisks metabolisma ce\u013c\u0161, lai gan tas nav p\u0101rbaud\u012bts cilv\u0113kiem.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Kam\u0113r <a href=\"https:\/\/www.statnews.com\/2017\/01\/10\/moderna-trouble-mrna\/\" target=\"_blank\" rel=\"noreferrer noopener\">Moderna<\/a> p\u0101rtrauca ALC-0315 aknu nesader\u012bbas d\u0113\u013c un izstr\u0101d\u0101ja pa\u0161u SM platformu (ALC-0315 izr\u0101d\u012bj\u0101s p\u0101r\u0101k toksisks aknu slim\u012bbas Kriglera-Nad\u017eara sindroma g\u0113nu terapijai, t\u0101p\u0113c toreiz\u0113jais p\u0113tniec\u012bbas partneris, kas bija iesaist\u012bts p\u0113tniec\u012bb\u0101, p\u0101rtrauca ALC-0315. <em>Alexion<\/em> p\u0101rtrauca p\u0113t\u012bjumu dro\u0161\u012bbas apsv\u0113rumu d\u0113\u013c), BioNTech \/ Pfizer turpina tos izmantot pret\u0113ji savam lab\u0101kajam sapr\u0101tam.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Der_Weg_in_die_Leber_und_die_Lange_der_Kette\"><\/span>Ce\u013c\u0161 uz akn\u0101m un \u0137\u0113des garums<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">... tiks turpin\u0101ts ...<\/p>","protected":false},"excerpt":{"rendered":"<p><span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Las\u012b\u0161anas laiks<\/span> <span class=\"rt-time\"> 2<\/span> <span class=\"rt-label rt-postfix\">protokols<\/span><\/span>Jo \u012bs\u0101ka ir PEG (polietil\u0113nglikola) \u0137\u0113de, jo liel\u0101ks ir LNP toksiskums. BioNTech to skaidro sav\u0101 10.05.2021. gada 10. maija publik\u0101cij\u0101 \"LNP-mRNA neimunoterapijas pielietojums: maksim\u0101la efektivit\u0101te un dro\u0161\u012bba\", lai gan formul\u0113 to nedaudz cit\u0101di: \"Maksim\u0101la efektivit\u0101te\".Toksiskuma pamat\u0101 ir fakts, ka visi tr\u012bs joniz\u0113jamie katjonu lip\u012bdi nav biolo\u0123iski no\u0101rd\u0101mi un t\u0101p\u0113c to toksiskums ir...&nbsp;<a href=\"https:\/\/csiag.eu\/lv\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/\" rel=\"bookmark\">Las\u012bt vair\u0101k \"<span class=\"screen-reader-text\">LNP toksicit\u0101te atkar\u012bb\u0101 no PEG \u0137\u0113des garuma<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[628,316,1078],"tags":[5067,5066,5074,22,36,5080,5079,5069,5075,5071,4812,105,5073,5077,5070,5072,23,5076,5078,44],"class_list":["post-10036","post","type-post","status-publish","format-standard","hentry","category-corona","category-corona-blog","category-medizin","tag-alc-159","tag-alc-315","tag-alnylam","tag-biontech","tag-bnt162b2","tag-cholesterol","tag-dlin-mc3-dma","tag-dmg-peg2000","tag-elasomeran","tag-ionisierbar","tag-lnp","tag-moderna","tag-patisiran","tag-peg-lipid","tag-peg2000-dmg","tag-pegyliert","tag-pfizer","tag-phosholipid","tag-sterol","tag-tozinameran"],"modified_by":"Achim Goerner","_links":{"self":[{"href":"https:\/\/csiag.eu\/lv\/wp-json\/wp\/v2\/posts\/10036","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csiag.eu\/lv\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csiag.eu\/lv\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csiag.eu\/lv\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csiag.eu\/lv\/wp-json\/wp\/v2\/comments?post=10036"}],"version-history":[{"count":0,"href":"https:\/\/csiag.eu\/lv\/wp-json\/wp\/v2\/posts\/10036\/revisions"}],"wp:attachment":[{"href":"https:\/\/csiag.eu\/lv\/wp-json\/wp\/v2\/media?parent=10036"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csiag.eu\/lv\/wp-json\/wp\/v2\/categories?post=10036"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csiag.eu\/lv\/wp-json\/wp\/v2\/tags?post=10036"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}