{"id":10036,"date":"2025-06-02T19:05:44","date_gmt":"2025-06-02T19:05:44","guid":{"rendered":"https:\/\/csiag.eu\/?p=10036"},"modified":"2025-06-03T20:37:17","modified_gmt":"2025-06-03T20:37:17","slug":"toxicita-lnp-v-zavislosti-od-dlzky-retazca-kolikov","status":"publish","type":"post","link":"https:\/\/csiag.eu\/sk\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/","title":{"rendered":"Toxicita LNP v z\u00e1vislosti od d\u013a\u017eky re\u0165azca PEG"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_87_1 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Obsah<\/p>\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/csiag.eu\/sk\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Welche_LNPs_wurden_verwendet\" >Ktor\u00e9 LNP boli pou\u017eit\u00e9?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/csiag.eu\/sk\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Toxizitat_wurde_nicht_durch_Studien_uberpruft\" >Toxicita nebola overen\u00e1 \u0161t\u00fadiami<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/csiag.eu\/sk\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Akkumulation_in_der_Leber\" >Hromadenie v pe\u010deni<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/csiag.eu\/sk\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Der_Weg_in_die_Leber_und_die_Lange_der_Kette\" >Cesta do pe\u010dene a d\u013a\u017eka re\u0165azca<\/a><\/li><\/ul><\/nav><\/div>\n<span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">\u010cas \u010d\u00edtania<\/span> <span class=\"rt-time\"> 2<\/span> <span class=\"rt-label rt-postfix\">z\u00e1pisnice<\/span><\/span>\n<p class=\"wp-block-paragraph\">\u010c\u00edm krat\u0161\u00ed je re\u0165azec PEG (polyetyl\u00e9nglykol), t\u00fdm vy\u0161\u0161ia je toxicita LNP. Spolo\u010dnos\u0165 BioNTech to vysvet\u013euje vo svojom <a href=\"https:\/\/www.mdpi.com\/2227-9059\/9\/5\/530\" target=\"_blank\" rel=\"noreferrer noopener\">Publik\u00e1cia<\/a> \"Non-Immunotherapy Application of LNP-mRNA: Maximising Efficacy and Safety\" z 10.05.2021, aj ke\u010f formulovan\u00e9 - trochu - inak: \"Maximising Efficacy\".<br>Toxicita je zalo\u017een\u00e1 na skuto\u010dnosti, \u017ee v\u0161etky tri ionizovate\u013en\u00e9 kati\u00f3nov\u00e9 lipidy nie s\u00fa biologicky odb\u00farate\u013en\u00e9 a ich nevyhnutn\u00e1 akumul\u00e1cia v tele m\u00e1 cytotoxick\u00e9 d\u00f4sledky.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Welche_LNPs_wurden_verwendet\"><\/span>Ktor\u00e9 LNP boli pou\u017eit\u00e9?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Pfizer<\/em> \/ <em>BioNTech<\/em> - BNT162b2 - <a href=\"https:\/\/www.echelon-inc.com\/product\/alc-0315\/\" target=\"_blank\" rel=\"noreferrer noopener\">ALC-0315<\/a> (ionizovate\u013en\u00e9) a <a href=\"https:\/\/www.echelon-inc.com\/product\/alc-0159\/\" target=\"_blank\" rel=\"noreferrer noopener\">ALC-0159<\/a> (PEGylovan\u00e9)<br><em>Moderna<\/em> - <a href=\"https:\/\/www.echelon-inc.com\/product\/sm-102\/\" target=\"_blank\" rel=\"noreferrer noopener\">SM-102<\/a> (ionizovate\u013en\u00e9) a <a href=\"https:\/\/www.echelon-inc.com\/product\/dmg-peg-2000\/\" target=\"_blank\" rel=\"noreferrer noopener\">PEG2000-DMG<\/a> (PEGylovan\u00e9)<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"562\" src=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-1024x562.png\" alt=\"\" class=\"wp-image-10045\" srcset=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-1024x562.png 1024w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-300x165.png 300w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-768x421.png 768w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-18x10.png 18w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image.png 1456w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">V pr\u00edpade v\u0161etk\u00fdch uveden\u00fdch lipidov v\u00fdrobcovia (napr. <a href=\"https:\/\/www.echelon-inc.com\/product\/alc-0315\/#tab-description\" target=\"_blank\" rel=\"noreferrer noopener\">Echelon Biosciences<\/a>) \"... Toto je produkt v kvalite \u010dinidla, ur\u010den\u00fd len na v\u00fdskumn\u00e9 \u00fa\u010dely.\"<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Toxizitat_wurde_nicht_durch_Studien_uberpruft\"><\/span>Toxicita nebola overen\u00e1 \u0161t\u00fadiami<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Pod\u013ea <a href=\"https:\/\/www.tga.gov.au\/sites\/default\/files\/foi-2389-06.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Publik\u00e1cia<\/a> \"Spr\u00e1va o neklinickom hodnoten\u00ed BNT 162b2 mRNA COVID-19 vakc\u00edny COMIRNATY\u2122\" austr\u00e1lskej vl\u00e1dy - ministerstva zdravotn\u00edctva z janu\u00e1ra 2021 sa nach\u00e1dza na strane 11: \"Toxicita samotn\u00e9ho zlo\u017eenia LNP alebo nov\u00fdch pomocn\u00fdch l\u00e1tok nebola osobitne sk\u00faman\u00e1.\"<br>In\u00fdmi slovami, neboli vykonan\u00e9 \u017eiadne \u0161t\u00fadie toxicity pou\u017e\u00edvania a \u00fa\u010dinkov nov\u00fdch pomocn\u00fdch l\u00e1tok LNP uveden\u00fdch vy\u0161\u0161ie.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Akkumulation_in_der_Leber\"><\/span>Hromadenie v pe\u010deni<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Mnoh\u00e9 lieky sa \u010diasto\u010dne alebo \u00faplne metabolizuj\u00fa v pe\u010deni a dost\u00e1vaj\u00fa sa do krvn\u00e9ho obehu. Vy\u0161\u0161ie uveden\u00e1 pomocn\u00e1 l\u00e1tka ALC-315 sa tie\u017e hromad\u00ed v pe\u010deni, ako je zrejm\u00e9 z <a href=\"https:\/\/www.judicialwatch.org\/wp-content\/uploads\/2022\/03\/JW-v-HHS-prod-3-02418.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">\u010ciasto\u010dn\u00e1 odpove\u010f na ot\u00e1zku \u010d. 2021-4379<\/a> pod\u013ea z\u00e1kona o slobodnom pr\u00edstupe k inform\u00e1ci\u00e1m (Freedom of Information Act - FOIA), ktor\u00fd je predmetom s\u0165a\u017enosti vo veci Judicial Watch, Inc. v. U.S. Department of Health and Human Services (21-cv-2418), v s\u00fa\u010dasnosti prejedn\u00e1vanej na okresnom s\u00fade USA pre okres Columbia, na strane 16 z 466:<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"542\" src=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-1024x542.png\" alt=\"\" class=\"wp-image-10054\" srcset=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-1024x542.png 1024w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-300x159.png 300w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-768x407.png 768w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-18x10.png 18w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3.png 1212w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Uveden\u00e9 aj na strane 45 uvedenej spr\u00e1vy. <a href=\"https:\/\/www.tga.gov.au\/sites\/default\/files\/foi-2389-06.pdf\" target=\"_blank\" rel=\"noopener\">Spr\u00e1vy<\/a>:<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"55\" src=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-1024x55.png\" alt=\"\" class=\"wp-image-10060\" srcset=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-1024x55.png 1024w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-300x16.png 300w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-768x42.png 768w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-18x1.png 18w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4.png 1218w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Na strane 46 sa uv\u00e1dza \u010disto teoreticky predpokladan\u00e1 metabolick\u00e1 dr\u00e1ha na z\u00e1klade experimentov in vitro, ktor\u00e1 v\u0161ak nebola overen\u00e1 u \u013eud\u00ed.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Zatia\u013e \u010do <a href=\"https:\/\/www.statnews.com\/2017\/01\/10\/moderna-trouble-mrna\/\" target=\"_blank\" rel=\"noreferrer noopener\">Moderna<\/a> ukon\u010dila v\u00fdrobu lieku ALC-0315 z d\u00f4vodu nekompatibility s pe\u010de\u0148ou a vyvinula samotn\u00fa platformu SM (ALC-0315 sa uk\u00e1zal ako pr\u00edli\u0161 toxick\u00fd pre g\u00e9nov\u00fa terapiu ochorenia pe\u010dene Criglerovho-Najjarovho syndr\u00f3mu, tak\u017ee vtedaj\u0161\u00ed v\u00fdskumn\u00fd partner <em>Alexion<\/em> zastavila \u0161t\u00fadiu z bezpe\u010dnostn\u00fdch d\u00f4vodov), spolo\u010dnos\u0165 BioNTech\/Pfizer ich na\u010falej pou\u017e\u00edva proti svojmu najlep\u0161iemu \u00fasudku.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Der_Weg_in_die_Leber_und_die_Lange_der_Kette\"><\/span>Cesta do pe\u010dene a d\u013a\u017eka re\u0165azca<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">... bude pokra\u010dova\u0165...<\/p>","protected":false},"excerpt":{"rendered":"<p><span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">\u010cas \u010d\u00edtania<\/span> <span class=\"rt-time\"> 2<\/span> <span class=\"rt-label rt-postfix\">z\u00e1pisnice<\/span><\/span>\u010c\u00edm krat\u0161\u00ed je re\u0165azec PEG (polyetyl\u00e9nglykol), t\u00fdm vy\u0161\u0161ia je toxicita LNP. Spolo\u010dnos\u0165 BioNTech to vysvet\u013euje vo svojej publik\u00e1cii \"Non-Immunotherapy Application of LNP-mRNA: Maximising Efficacy and Safety\" z 10.5.2021, aj ke\u010f formulovanej - trochu - inak: \"Maximising Efficacy\". toxicita vych\u00e1dza zo skuto\u010dnosti, \u017ee v\u0161etky tri ionizovate\u013en\u00e9 kati\u00f3nov\u00e9 lipidy nie s\u00fa biologicky odb\u00farate\u013en\u00e9, a preto je ich toxicita...&nbsp;<a href=\"https:\/\/csiag.eu\/sk\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/\" rel=\"bookmark\">\u010c\u00edta\u0165 viac \"<span class=\"screen-reader-text\">Toxicita LNP v z\u00e1vislosti od d\u013a\u017eky re\u0165azca PEG<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[628,316,1078],"tags":[5067,5066,5074,22,36,5080,5079,5069,5075,5071,4812,105,5073,5077,5070,5072,23,5076,5078,44],"class_list":["post-10036","post","type-post","status-publish","format-standard","hentry","category-corona","category-corona-blog","category-medizin","tag-alc-159","tag-alc-315","tag-alnylam","tag-biontech","tag-bnt162b2","tag-cholesterol","tag-dlin-mc3-dma","tag-dmg-peg2000","tag-elasomeran","tag-ionisierbar","tag-lnp","tag-moderna","tag-patisiran","tag-peg-lipid","tag-peg2000-dmg","tag-pegyliert","tag-pfizer","tag-phosholipid","tag-sterol","tag-tozinameran"],"modified_by":"Achim Goerner","_links":{"self":[{"href":"https:\/\/csiag.eu\/sk\/wp-json\/wp\/v2\/posts\/10036","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csiag.eu\/sk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csiag.eu\/sk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csiag.eu\/sk\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csiag.eu\/sk\/wp-json\/wp\/v2\/comments?post=10036"}],"version-history":[{"count":0,"href":"https:\/\/csiag.eu\/sk\/wp-json\/wp\/v2\/posts\/10036\/revisions"}],"wp:attachment":[{"href":"https:\/\/csiag.eu\/sk\/wp-json\/wp\/v2\/media?parent=10036"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csiag.eu\/sk\/wp-json\/wp\/v2\/categories?post=10036"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csiag.eu\/sk\/wp-json\/wp\/v2\/tags?post=10036"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}