{"id":10036,"date":"2025-06-02T19:05:44","date_gmt":"2025-06-02T19:05:44","guid":{"rendered":"https:\/\/csiag.eu\/?p=10036"},"modified":"2025-06-03T20:37:17","modified_gmt":"2025-06-03T20:37:17","slug":"peg-zincirinin-uzunluguna-bagli-olarak-lnpnin-toksisitesi","status":"publish","type":"post","link":"https:\/\/csiag.eu\/tr\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/","title":{"rendered":"PEG zincirinin uzunlu\u011funa ba\u011fl\u0131 olarak LNP'nin toksisitesi"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_86 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u0130\u00e7indekiler tablosu<\/p>\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/csiag.eu\/tr\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Welche_LNPs_wurden_verwendet\" >Hangi LNP'ler kullan\u0131ld\u0131?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/csiag.eu\/tr\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Toxizitat_wurde_nicht_durch_Studien_uberpruft\" >Toksisite \u00e7al\u0131\u015fmalarla do\u011frulanmam\u0131\u015ft\u0131r<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/csiag.eu\/tr\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Akkumulation_in_der_Leber\" >Karaci\u011ferde birikim<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/csiag.eu\/tr\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Der_Weg_in_die_Leber_und_die_Lange_der_Kette\" >Karaci\u011fere giden yol ve zincirin uzunlu\u011fu<\/a><\/li><\/ul><\/nav><\/div>\n<span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Okuma s\u00fcresi<\/span> <span class=\"rt-time\"> 2<\/span> <span class=\"rt-label rt-postfix\">dakika<\/span><\/span>\n<p class=\"wp-block-paragraph\">PEG zinciri (polietilen glikol) ne kadar k\u0131sa olursa, LNP'nin toksisitesi o kadar y\u00fcksek olur. BioNTech bunu \u015fu \u015fekilde a\u00e7\u0131klamaktad\u0131r <a href=\"https:\/\/www.mdpi.com\/2227-9059\/9\/5\/530\" target=\"_blank\" rel=\"noreferrer noopener\">Yay\u0131n<\/a> \"Non-Immunotherapy Application of LNP-mRNA: Maximising Efficacy and Safety\" (LNP-mRNA'n\u0131n \u0130mm\u00fcnoterapi D\u0131\u015f\u0131 Uygulamas\u0131: Etkinli\u011fin ve G\u00fcvenli\u011fin En \u00dcst D\u00fczeye \u00c7\u0131kar\u0131lmas\u0131), 10.05.2021'de - biraz farkl\u0131 ifade edilmi\u015f olsa da: \"Maximising Efficacy\".<br>Toksisite, iyonize olabilen katyonik lipidlerin \u00fc\u00e7\u00fcn\u00fcn de biyolojik olarak par\u00e7alanamamas\u0131na ve v\u00fccutta ka\u00e7\u0131n\u0131lmaz olarak birikmelerinin sitotoksik sonu\u00e7lara yol a\u00e7mas\u0131na dayanmaktad\u0131r.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Welche_LNPs_wurden_verwendet\"><\/span>Hangi LNP'ler kullan\u0131ld\u0131?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Pfizer<\/em> \/ <em>BioNTech<\/em> - BNT162b2 - <a href=\"https:\/\/www.echelon-inc.com\/product\/alc-0315\/\" target=\"_blank\" rel=\"noreferrer noopener\">ALC-0315<\/a> (iyonize edilebilir) ve <a href=\"https:\/\/www.echelon-inc.com\/product\/alc-0159\/\" target=\"_blank\" rel=\"noreferrer noopener\">ALC-0159<\/a> (PEGillenmi\u015f)<br><em>Moderna<\/em> - <a href=\"https:\/\/www.echelon-inc.com\/product\/sm-102\/\" target=\"_blank\" rel=\"noreferrer noopener\">SM-102<\/a> (iyonize edilebilir) ve <a href=\"https:\/\/www.echelon-inc.com\/product\/dmg-peg-2000\/\" target=\"_blank\" rel=\"noreferrer noopener\">PEG2000-DMG<\/a> (PEGillenmi\u015f)<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"562\" src=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-1024x562.png\" alt=\"\" class=\"wp-image-10045\" srcset=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-1024x562.png 1024w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-300x165.png 300w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-768x421.png 768w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-18x10.png 18w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image.png 1456w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">Yukar\u0131da bahsedilen t\u00fcm lipidler i\u00e7in \u00fcreticiler (\u00f6rn. <a href=\"https:\/\/www.echelon-inc.com\/product\/alc-0315\/#tab-description\" target=\"_blank\" rel=\"noreferrer noopener\">Echelon Biosciences<\/a>) \"... Bu reaktif s\u0131n\u0131f\u0131 bir \u00fcr\u00fcnd\u00fcr, sadece ara\u015ft\u0131rma ama\u00e7l\u0131 kullan\u0131m i\u00e7indir.\"<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Toxizitat_wurde_nicht_durch_Studien_uberpruft\"><\/span>Toksisite \u00e7al\u0131\u015fmalarla do\u011frulanmam\u0131\u015ft\u0131r<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Buna g\u00f6re <a href=\"https:\/\/www.tga.gov.au\/sites\/default\/files\/foi-2389-06.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Yay\u0131n<\/a> Avustralya H\u00fck\u00fcmeti - Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131'n\u0131n Ocak 2021 tarihli \"Klinik Olmayan De\u011ferlendirme Raporu BNT 162b2 mRNA COVID-19 a\u015f\u0131s\u0131 COMIRNATY\u2122\" sayfa 11'de okunabilir: \"LNP form\u00fclasyonunun veya tek ba\u015f\u0131na yeni yard\u0131mc\u0131 maddelerin toksisitesi \u00f6zel olarak incelenmemi\u015ftir.\"<br>Ba\u015fka bir deyi\u015fle, yukar\u0131da bahsedilen yeni LNP yard\u0131mc\u0131 maddelerinin kullan\u0131m\u0131 ve etkileri \u00fczerine herhangi bir toksisite \u00e7al\u0131\u015fmas\u0131 yap\u0131lmam\u0131\u015ft\u0131r.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Akkumulation_in_der_Leber\"><\/span>Karaci\u011ferde birikim<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Bir\u00e7ok ila\u00e7 k\u0131smen veya tamamen karaci\u011fer taraf\u0131ndan metabolize edilir ve kan dola\u015f\u0131m\u0131na kar\u0131\u015f\u0131r. Yukar\u0131da bahsedilen yard\u0131mc\u0131 madde ALC-315 de karaci\u011ferde birikir, a\u015fa\u011f\u0131daki grafikten de g\u00f6r\u00fclebilece\u011fi gibi <a href=\"https:\/\/www.judicialwatch.org\/wp-content\/uploads\/2022\/03\/JW-v-HHS-prod-3-02418.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">2021-4379 numaral\u0131 sorunun k\u0131smi cevab\u0131<\/a> Bilgi Edinme \u00d6zg\u00fcrl\u00fc\u011f\u00fc Yasas\u0131 (FOIA) kapsam\u0131nda, halen ABD Columbia B\u00f6lgesi B\u00f6lge Mahkemesi'nde devam etmekte olan Judicial Watch, Inc. v. U.S. Department of Health and Human Services (21-cv-2418) davas\u0131n\u0131n 466. sayfas\u0131n\u0131n 16. paragraf\u0131nda yer alan \u015fik\u00e2yetin konusudur:<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"542\" src=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-1024x542.png\" alt=\"\" class=\"wp-image-10054\" srcset=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-1024x542.png 1024w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-300x159.png 300w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-768x407.png 768w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-18x10.png 18w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3.png 1212w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Yukar\u0131da bahsi ge\u00e7en raporun 45. sayfas\u0131nda da belirtilmi\u015ftir. <a href=\"https:\/\/www.tga.gov.au\/sites\/default\/files\/foi-2389-06.pdf\" target=\"_blank\" rel=\"noopener\">Raporlar<\/a>:<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"55\" src=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-1024x55.png\" alt=\"\" class=\"wp-image-10060\" srcset=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-1024x55.png 1024w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-300x16.png 300w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-768x42.png 768w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-18x1.png 18w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4.png 1218w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Sayfa 46'da, tamamen teorik olarak varsay\u0131lan metabolik yol, in vitro deneyler temelinde \u00f6zetlenmi\u015ftir, ancak bu insanlarda do\u011frulanmam\u0131\u015ft\u0131r.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Her ne kadar <a href=\"https:\/\/www.statnews.com\/2017\/01\/10\/moderna-trouble-mrna\/\" target=\"_blank\" rel=\"noreferrer noopener\">Moderna<\/a> ALC-0315'i karaci\u011fer uyumsuzlu\u011fu nedeniyle durdurdu ve SM platformunu kendisi geli\u015ftirdi (ALC-0315'in karaci\u011fer hastal\u0131\u011f\u0131 Crigler-Najjar sendromunun gen tedavisi i\u00e7in \u00e7ok toksik oldu\u011fu kan\u0131tlanm\u0131\u015ft\u0131, b\u00f6ylece o zamanki ara\u015ft\u0131rma orta\u011f\u0131 <em>Alexion<\/em> g\u00fcvenlik nedenleriyle \u00e7al\u0131\u015fmay\u0131 durdurdu), BioNTech \/ Pfizer daha iyi karar\u0131na ra\u011fmen bunlar\u0131 kullanmaya devam ediyor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Der_Weg_in_die_Leber_und_die_Lange_der_Kette\"><\/span>Karaci\u011fere giden yol ve zincirin uzunlu\u011fu<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">... devam edecek ...<\/p>","protected":false},"excerpt":{"rendered":"<p><span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Okuma s\u00fcresi<\/span> <span class=\"rt-time\"> 2<\/span> <span class=\"rt-label rt-postfix\">dakika<\/span><\/span>PEG zinciri (polietilen glikol) ne kadar k\u0131sa olursa, LNP'nin toksisitesi o kadar y\u00fcksek olur. BioNTech bunu 10.05.2021 tarihli \"LNP-mRNA'n\u0131n \u0130mm\u00fcnoterapi D\u0131\u015f\u0131 Uygulamas\u0131: Etkinli\u011fi ve G\u00fcvenli\u011fi En \u00dcst D\u00fczeye \u00c7\u0131karma\" ba\u015fl\u0131kl\u0131 yay\u0131n\u0131nda -biraz farkl\u0131 bir \u015fekilde ifade edilmi\u015f olsa da- a\u00e7\u0131klamaktad\u0131r: \"Etkinli\u011fi En \u00dcst D\u00fczeye \u00c7\u0131karma\" Toksisite, iyonize olabilen katyonik lipitlerin \u00fc\u00e7\u00fcn\u00fcn de biyolojik olarak par\u00e7alanamaz olmas\u0131na ve bu nedenle toksisitelerinin...&nbsp;<a href=\"https:\/\/csiag.eu\/tr\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/\" rel=\"bookmark\">Daha fazlas\u0131n\u0131 oku \"<span class=\"screen-reader-text\">PEG zincirinin uzunlu\u011funa ba\u011fl\u0131 olarak LNP'nin toksisitesi<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[628,316,1078],"tags":[5067,5066,5074,22,36,5080,5079,5069,5075,5071,4812,105,5073,5077,5070,5072,23,5076,5078,44],"class_list":["post-10036","post","type-post","status-publish","format-standard","hentry","category-corona","category-corona-blog","category-medizin","tag-alc-159","tag-alc-315","tag-alnylam","tag-biontech","tag-bnt162b2","tag-cholesterol","tag-dlin-mc3-dma","tag-dmg-peg2000","tag-elasomeran","tag-ionisierbar","tag-lnp","tag-moderna","tag-patisiran","tag-peg-lipid","tag-peg2000-dmg","tag-pegyliert","tag-pfizer","tag-phosholipid","tag-sterol","tag-tozinameran"],"modified_by":"Achim Goerner","_links":{"self":[{"href":"https:\/\/csiag.eu\/tr\/wp-json\/wp\/v2\/posts\/10036","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csiag.eu\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csiag.eu\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csiag.eu\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csiag.eu\/tr\/wp-json\/wp\/v2\/comments?post=10036"}],"version-history":[{"count":0,"href":"https:\/\/csiag.eu\/tr\/wp-json\/wp\/v2\/posts\/10036\/revisions"}],"wp:attachment":[{"href":"https:\/\/csiag.eu\/tr\/wp-json\/wp\/v2\/media?parent=10036"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csiag.eu\/tr\/wp-json\/wp\/v2\/categories?post=10036"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csiag.eu\/tr\/wp-json\/wp\/v2\/tags?post=10036"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}