{"id":6701,"date":"2024-02-27T17:39:49","date_gmt":"2024-02-27T17:39:49","guid":{"rendered":"https:\/\/csiag.eu\/?p=6701"},"modified":"2026-02-11T14:34:05","modified_gmt":"2026-02-11T14:34:05","slug":"histamin-ve-histamin-intoleransi-isabet","status":"publish","type":"post","link":"https:\/\/csiag.eu\/tr\/blog\/2024\/02\/27\/histamin-und-histamin-intoleranz-hit\/","title":{"rendered":"Histamin ve histamin intolerans\u0131 (HIT)"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_83 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u0130\u00e7indekiler tablosu<\/p>\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/csiag.eu\/tr\/blog\/2024\/02\/27\/histamin-und-histamin-intoleranz-hit\/#Histamin_%E2%80%93_was_ist_das\" >Histamin - nedir bu?<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/csiag.eu\/tr\/blog\/2024\/02\/27\/histamin-und-histamin-intoleranz-hit\/#Biosynthese_und_Speicherung\" >Biyosentez ve depolama<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/csiag.eu\/tr\/blog\/2024\/02\/27\/histamin-und-histamin-intoleranz-hit\/#Freisetzung\" >Serbest B\u0131rak<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/csiag.eu\/tr\/blog\/2024\/02\/27\/histamin-und-histamin-intoleranz-hit\/#Extern_provozierte_Freisetzung\" >D\u0131\u015far\u0131dan provoke edilen sal\u0131n\u0131m<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/csiag.eu\/tr\/blog\/2024\/02\/27\/histamin-und-histamin-intoleranz-hit\/#Funktionalitat\" >\u0130\u015flevsellik<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/csiag.eu\/tr\/blog\/2024\/02\/27\/histamin-und-histamin-intoleranz-hit\/#Abbau\" >S\u00f6k\u00fcm<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/csiag.eu\/tr\/blog\/2024\/02\/27\/histamin-und-histamin-intoleranz-hit\/#Histamin-Werte\" >Histamin de\u011ferleri<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/csiag.eu\/tr\/blog\/2024\/02\/27\/histamin-und-histamin-intoleranz-hit\/#Histaminsteigernde_Komponenten\" >Histamin artt\u0131r\u0131c\u0131 bile\u015fenler<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/csiag.eu\/tr\/blog\/2024\/02\/27\/histamin-und-histamin-intoleranz-hit\/#Histaminsenkende_Komponenten\" >Histamin d\u00fc\u015f\u00fcr\u00fcc\u00fc bile\u015fenler<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/csiag.eu\/tr\/blog\/2024\/02\/27\/histamin-und-histamin-intoleranz-hit\/#Histaminreiche_Nahrungsmittel\" >Histamin a\u00e7\u0131s\u0131ndan zengin g\u0131dalar<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/csiag.eu\/tr\/blog\/2024\/02\/27\/histamin-und-histamin-intoleranz-hit\/#Histaminarme_Nahrungsmittel\" >D\u00fc\u015f\u00fck histaminli g\u0131dalar<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/csiag.eu\/tr\/blog\/2024\/02\/27\/histamin-und-histamin-intoleranz-hit\/#Pathologische_Aspekte\" >Patolojik y\u00f6nler<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/csiag.eu\/tr\/blog\/2024\/02\/27\/histamin-und-histamin-intoleranz-hit\/#Labormedizin_%E2%80%93_Differentialdiagnostik\" >Laboratuvar t\u0131bb\u0131 - Ay\u0131r\u0131c\u0131 tan\u0131<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Okuma s\u00fcresi<\/span> <span class=\"rt-time\"> 4<\/span> <span class=\"rt-label rt-postfix\">dakika<\/span><\/span>\n<p>Histamin ve histamin intolerans\u0131 (HIT) - a\u015fa\u011f\u0131da daha ayr\u0131nt\u0131l\u0131 olarak ele al\u0131nacak heyecan verici bir konu.<\/p>\n\n\n\n<p>Alerji hastalar\u0131, \u00f6rne\u011fin saman nezlesi hastalar\u0131, polen zamanlar\u0131nda alerjik semptomlardan kurtulmalar\u0131n\u0131 sa\u011flayan antihistaminiklere a\u015finad\u0131r.<\/p>\n\n\n\n<p>Ancak v\u00fccutta histamin salg\u0131lanmas\u0131na ve histamin fazlal\u0131\u011f\u0131na yol a\u00e7abilen sadece polen de\u011fildir, diyet veya histamin par\u00e7alay\u0131c\u0131 maddelerin \u00fcretim eksikli\u011fi gibi di\u011fer fakt\u00f6rler de a\u015f\u0131r\u0131 histamin seviyelerinin nedeni olabilir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Histamin_%E2%80%93_was_ist_das\"><\/span>Histamin - nedir bu?<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<p><strong>Hist<\/strong>amin (eski Yunanca \u1f31\u03c3\u03c4\u03cc\u03c2 histos = doku) bir biyojeniktir (eski Yunanca \u03b2\u03af\u03bf\u03c2 bios = ya\u015fam ve -genesis = ortaya \u00e7\u0131k\u0131\u015f) <strong>Amin<\/strong> (amonya\u011f\u0131n organik t\u00fcrevleri (NH3)), a\u011f\u0131rl\u0131kl\u0131 olarak deri, akci\u011ferler, mide, ba\u011f\u0131rsaklar ve diensefalonda bir doku hormonu olarak ortaya \u00e7\u0131kar.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Biosynthese_und_Speicherung\"><\/span>Biyosentez ve depolama<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Histamin mast h\u00fccreleri, epidermis, gastrik mukoza ve sinir h\u00fccrelerinde sentezlenir ve heparine ba\u011fl\u0131 vezik\u00fcllerde depolan\u0131r. Histidin amino asidinden, histidin dekarboksilaz enzimi taraf\u0131ndan piridoksal fosfata ba\u011f\u0131ml\u0131 dekarboksilasyon ile tek a\u015famal\u0131 bir reaksiyonda olu\u015fturulur.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Freisetzung\"><\/span>Serbest B\u0131rak<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Histamin, \u00f6rne\u011fin mast h\u00fccreleri, bazofilik gran\u00fclositler, bron\u015f h\u00fccreleri, mukoza zarlar\u0131 ve gastrointestinal sistemden (ECL h\u00fccreleri gastrin, asetilkolin ve PACAP'tan histamin \u00fcretir (<em>hipofiz adenilat siklaz aktive edici polipeptit<\/em>) veya kompleman fakt\u00f6rlerinin (kompleman sistemi, spesifik olmayan humoral (antikor ve di\u011fer savunma ile ilgili proteinler) ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin bir par\u00e7as\u0131d\u0131r) IgE ile ind\u00fcklenen alerjik reaksiyonlar\u0131 vesilesiyle.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Extern_provozierte_Freisetzung\"><\/span>D\u0131\u015far\u0131dan provoke edilen sal\u0131n\u0131m<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>A\u015fa\u011f\u0131daki farmas\u00f6tikler histamin sal\u0131n\u0131m\u0131n\u0131n artmas\u0131na katk\u0131da bulunabilir:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Kas gev\u015feticiler<\/li>\n\n\n\n<li>Opiatlar<\/li>\n\n\n\n<li>Plazma geni\u015fletici<\/li>\n\n\n\n<li>X-\u0131\u015f\u0131n\u0131 kontrast maddesi<\/li>\n<\/ul>\n\n\n\n<p>G\u0131dalar da de\u011fi\u015fen konsantrasyonlarda histamin i\u00e7erir.<\/p>\n\n\n\n<p>U\u00e7ucu ya\u011flar dam\u0131tma i\u015flemi nedeniyle histamin \u0130\u00c7ERMEZ! <br>Bu nedenle, medyada yer alan ve HIT'den muzdarip ki\u015filerin portakal veya limon gibi u\u00e7ucu ya\u011flardan ka\u00e7\u0131nmas\u0131 gerekti\u011fi y\u00f6n\u00fcndeki tavsiyeler as\u0131ls\u0131zd\u0131r.<\/p>\n\n\n\n<p>U\u00e7ucu ya\u011flar su veya etanol (dam\u0131tma i\u015fleminden sonra uzakla\u015ft\u0131r\u0131l\u0131r) ile dam\u0131t\u0131larak elde edilir. Histamin suda ve etanolde \u00e7\u00f6z\u00fcn\u00fcr (<a href=\"https:\/\/de.wikipedia.org\/wiki\/Histamin\" target=\"_blank\" rel=\"noreferrer noopener\">Kaynak<\/a>), ancak eterde de\u011fil, bu nedenle \u00e7\u00f6zelti i\u00e7inde kalacakt\u0131r. Bu nedenle u\u00e7ucu ya\u011f herhangi bir histamin i\u00e7ermez.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Funktionalitat\"><\/span>\u0130\u015flevsellik<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Histaminin ana i\u015flevi, alerjenlere veya yabanc\u0131 maddelere kar\u015f\u0131 savunmada yer almas\u0131d\u0131r.<br>H\u00fccresel d\u00fczeyde histamin, histamin resept\u00f6r aktivasyonunu H<sub>1<\/sub> .. H<sub>4<\/sub>Bunlar da h\u00fccre d\u0131\u015f\u0131 sinyallerin h\u00fccre i\u00e7ine (G proteinleri arac\u0131l\u0131\u011f\u0131yla), savunma reaksiyonlar\u0131na iletilmesinden sorumlu olan G proteinine ba\u011fl\u0131 resept\u00f6rlere aittir.<\/p>\n\n\n\n<p>MSS i\u00e7inde histamin, histaminerjik n\u00f6ronlarda bir n\u00f6rotransmitter olarak g\u00f6rev yapar. En y\u00fcksek histamin konsantrasyonu hipotalamusta bulunur.<\/p>\n\n\n\n<p>Uyku-uyan\u0131kl\u0131k ritmi, H<sub>1<\/sub>-resept\u00f6r\u00fc d\u00fczenlenir. Kusma da bu resept\u00f6r arac\u0131l\u0131\u011f\u0131yla tetiklenir. Bu resept\u00f6r\u00fcn i\u015ftah, kan bas\u0131nc\u0131, v\u00fccut \u0131s\u0131s\u0131 ve a\u011fr\u0131 hissinin d\u00fczenlenmesindeki rol\u00fc hala belirsizdir.<\/p>\n\n\n\n<p>Ba\u011f\u0131rsak hareketlili\u011fine ek olarak, histamin ayr\u0131ca H<sub>2<\/sub>-resept\u00f6rleri mide asidi \u00fcretimini d\u00fczenler.<br>H'nin aktivasyonu<sub>2<\/sub>-resept\u00f6rleri kalbin at\u0131m g\u00fcc\u00fcnde ve frekans\u0131nda art\u0131\u015fa neden olur.<\/p>\n\n\n\n<p>Presinaptik H<sub>3<\/sub>-resept\u00f6rleri dopamin, glutamin, noradrenalin ve serotonin n\u00f6rotransmitterlerinin etkisini etkiler.<\/p>\n\n\n\n<p>Histamin alerji, ast\u0131m, iltihaplanma ve yan\u0131klarda bir arac\u0131 olarak g\u00f6rev yapar ve a\u011fr\u0131ya neden olur, bron\u015flar, kan damarlar\u0131 (&gt; 80 \u03bcm), sindirim organlar\u0131 ve ayn\u0131 zamanda cilt gibi d\u00fcz kaslar\u0131n kas\u0131lmas\u0131na, ka\u015f\u0131nt\u0131 ve kurde\u015fene yol a\u00e7ar. Daha k\u00fc\u00e7\u00fck kan damarlar\u0131nda histamin vazodilatasyona neden olarak cildin k\u0131zarmas\u0131na yol a\u00e7ar.<br>Histamin ayn\u0131 zamanda adrenalin sal\u0131n\u0131m\u0131na da yol a\u00e7ar, \u00f6ncelikle H<sub>1<\/sub>-resept\u00f6rleri, adrenal bezlerden.<br>H4 resept\u00f6r\u00fcn\u00fcn aktivasyonu eozinofil gran\u00fclositlerin ve T lenfositlerin (timus h\u00fccreleri) uyar\u0131lmas\u0131na neden olur.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Abbau\"><\/span>S\u00f6k\u00fcm<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Histamin \u00f6ncelikle merkezi sinir sisteminde (MSS) histamin N-metiltransferaz enzimi taraf\u0131ndan par\u00e7alan\u0131r.<br>Aksi takdirde, bozunma \u00f6ncelikle diamin oksidazlar ve aldehit oksidazlar yoluyla ribozilasyondan sonra b\u00f6brekler yoluyla at\u0131lan imidazolilasetik aside ger\u00e7ekle\u015fir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Histamin-Werte\"><\/span>Histamin de\u011ferleri<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<p>Hepatik kanda histamin (total) i\u00e7in laboratuvar referans aral\u0131\u011f\u0131 (ELISA) &lt; 65,5 ng\/ml&#039;dir.<\/p>\n\n\n\n<p>10 mg\/ml akut solunum s\u0131k\u0131nt\u0131s\u0131, kan bas\u0131nc\u0131nda d\u00fc\u015fme, ishal, kusma, ciltte k\u0131zarma, ba\u015f a\u011fr\u0131s\u0131, kurde\u015fen, mide bulant\u0131s\u0131na yol a\u00e7arken, 100 mg\/ml buna ba\u011fl\u0131 olarak artan semptomlar\u0131n yan\u0131 s\u0131ra bay\u0131lma, y\u00fcz ve dilde \u015fi\u015fme ile zehirlenme olarak kabul edilir.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Histaminsteigernde_Komponenten\"><\/span>Histamin artt\u0131r\u0131c\u0131 bile\u015fenler<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Yukar\u0131da bahsedilen ila\u00e7lara ek olarak, MAO inhibit\u00f6rleri (adrenalin hormonunun ve dopamin, noradrenalin ve serotonin gibi n\u00f6rotransmitterlerin par\u00e7alanmas\u0131n\u0131 engeller) histamin art\u0131\u015f\u0131na neden olarak h\u00fccrede bahsedilen aminlerin daha y\u00fcksek plazma seviyeleri ve konsantrasyonlar\u0131 yoluyla \u00f6rne\u011fin depresyonda beyin metabolizmas\u0131n\u0131n d\u00fczensizle\u015fmesine yol a\u00e7ar. <\/p>\n\n\n\n<p>Histamin art\u0131r\u0131c\u0131 etkisi olan g\u0131dalar \u00f6rne\u011fin \u015funlard\u0131r: Alkol, ananas, muz, armut, fasulye, ac\u0131 biber, \u00e7ilek, guava, ahududu, kivi, mercimek, papaya, \u00e7ikolata, soya, bu\u011fday tohumu, turun\u00e7giller<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Histaminsenkende_Komponenten\"><\/span>Histamin d\u00fc\u015f\u00fcr\u00fcc\u00fc bile\u015fenler<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Elma, brokoli<strong>, <\/strong>Yaban mersini (yabani), hibiskus \u00e7ay\u0131, zencefil, papatya \u00e7ay\u0131, k\u0131rm\u0131z\u0131 biber, nane \u00e7ay\u0131, \u00e7\u00f6rek otu ya\u011f\u0131 histamin azalt\u0131c\u0131 besinler aras\u0131ndad\u0131r.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Histaminreiche_Nahrungsmittel\"><\/span>Histamin a\u00e7\u0131s\u0131ndan zengin g\u0131dalar<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Patl\u0131can, avokado, balzamik sirke, bal\u0131k (taze yakalanm\u0131\u015f veya dondurulmu\u015f olanlar hari\u00e7), maya \u00f6z\u00fc, yo\u011furt, kahve, kakao, peynir (ne kadar olgunsa o kadar fazla), mantar, k\u0131rm\u0131z\u0131 \u015farap, lahana tur\u015fusu (korni\u015fon vb. salamura g\u0131dalar), ek\u015fi krema, jambon, soya sosu, \u0131spanak, \u00e7ay, domates, \u015farap sirkesi, sitrik asit (konsantre) gibi g\u0131dalar diyetin histaminden zengin bile\u015fenleri aras\u0131ndad\u0131r.Ek\u015fi krema, jambon, soya sosu, \u0131spanak, \u00e7ay, domates, \u015farap sirkesi, sitrik asit (konsantre) diyetin histaminden zengin bile\u015fenleri aras\u0131ndad\u0131r ve HIT durumunda ka\u00e7\u0131n\u0131lmal\u0131d\u0131r.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Histaminarme_Nahrungsmittel\"><\/span>D\u00fc\u015f\u00fck histaminli g\u0131dalar<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Histamin oran\u0131 d\u00fc\u015f\u00fck olan ve bu nedenle HIT i\u00e7in g\u00fcvenli olan yiyecekler aras\u0131nda \u00f6rne\u011fin Agave \u015furubu, karnabahar, cr\u00e8me fra\u00eeche, k\u0131l\u00e7\u0131ks\u0131z bu\u011fday, yumurta, sirke (elma\/brendi), rezene, krem peynir, taze s\u00fct, meyve sular\u0131, arpa, lahana, salatal\u0131k, UHT s\u00fct, yulaf, yulaf s\u00fct\u00fc, dar\u0131, bal, s\u00fczme peynir, peynir (gen\u00e7 \u00e7e\u015fitler), havu\u00e7, patates, bitki \u00e7ay\u0131 (\u0131s\u0131rgan otu hari\u00e7), mutfak otlar\u0131, balkaba\u011f\u0131, kabak \u00e7ekirde\u011fi, zerde\u00e7al, p\u0131rasa, keten tohumu, macadamia, m\u0131s\u0131r, badem s\u00fct\u00fc, badem, paz\u0131, kestane, mozzarella, makarna, k\u0131rm\u0131z\u0131 biber, Brezilya f\u0131st\u0131\u011f\u0131, yaban havucu, f\u0131st\u0131k, kuark, kinoa, turp, ravent, pancar, k\u0131rm\u0131z\u0131 lahana, krema, salsify, kereviz, susam, ku\u015fkonmaz, tatl\u0131 patates, tatl\u0131 kremal\u0131 tereya\u011f\u0131, kabak, \u015feker, so\u011fan.<\/p>\n\n\n\n<p>Bir istisna d\u0131\u015f\u0131nda t\u00fcm salatalarda histamin oran\u0131 d\u00fc\u015f\u00fckt\u00fcr: roka.<\/p>\n\n\n\n<p>D\u00fc\u015f\u00fck histamin olarak kategorize edilebilecek meyveler \u00f6rne\u011fin Elma, kay\u0131s\u0131, b\u00f6\u011f\u00fcrtlen, k\u0131z\u0131lc\u0131k, hurma, nar, yaban mersini, frenk \u00fcz\u00fcm\u00fc, jostaberry, Trabzon hurmas\u0131, kiraz, li\u00e7i, mango, kavun, nektarin, \u015feftali, k\u0131z\u0131lc\u0131k, vi\u015fne, \u00fcz\u00fcm<\/p>\n\n\n\n<h1 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Pathologische_Aspekte\"><\/span>Patolojik y\u00f6nler<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<p>Yukar\u0131da belirtilen belirtilere ek olarak, a\u015fa\u011f\u0131daki HIT belirtileri de mevcuttur:<\/p>\n\n\n\n<p>Anksiyete, ishal, \u00e7arp\u0131nt\u0131, kardiyak aritmi, hiperhidroz, hipotansiyon, ba\u015f a\u011fr\u0131s\u0131 (migren dahil), konjonktivit, panik atak, rinit, rinore, mide ek\u015fimesi, ta\u015fikardi. <\/p>\n\n\n\n<p>Mide asidi seviyesinin y\u00fckselmesi histamin kaynakl\u0131 bir savunma reaksiyonuna i\u015faret edebilir.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Labormedizin_%E2%80%93_Differentialdiagnostik\"><\/span>Laboratuvar t\u0131bb\u0131 - Ay\u0131r\u0131c\u0131 tan\u0131<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Y\u00fcksek kan histamin seviyelerinin \u00fc\u00e7 nedeni olabilir:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Mast h\u00fccrelerinden a\u015f\u0131r\u0131 sal\u0131n\u0131m<br>- IgE arac\u0131l\u0131 alerjiler<br>- S\u00f6zde alerjiler<br>- Mast h\u00fccre aktivitesinde art\u0131\u015f (mast h\u00fccre say\u0131s\u0131nda art\u0131\u015f, membran stabilitesinde azalma)<\/li>\n\n\n\n<li>Histamin y\u0131k\u0131m bozuklu\u011fu<br>- Diamin oksidaz\u0131n (DAO) birincil (genetik) eksikli\u011fi <br>  veya histamin N-metiltransferaz (HNMT)<br>- Kuofer, B6 vitamini, \u00e7inko eksikli\u011fi ile tetiklenen DAO'nun ikincil aktivite eksikli\u011fi,<br>  Hasarl\u0131 ba\u011f\u0131rsak epiteli veya ila\u00e7 etkileri nedeniyle azalm\u0131\u015f DAO olu\u015fumu<\/li>\n\n\n\n<li>Ba\u011f\u0131rsakta histamin \u00fcreten bakterilerin artan kolonizasyonuna ba\u011fl\u0131 olarak artan histamin olu\u015fumu<\/li>\n<\/ul>\n\n\n\n<p>Kan testine g\u00f6re y\u00fcksek bir histamin seviyesi tespit edilmi\u015fse, d\u0131\u015fk\u0131 testi ile d\u0131\u015fk\u0131daki histamin konsantrasyonu belirlenmeli ve nedenin ay\u0131r\u0131c\u0131 tan\u0131s\u0131n\u0131 netle\u015ftirmek i\u00e7in d\u0131\u015fk\u0131da histamin \u00fcreten bakteriler tespit edilmelidir.<\/p>\n\n\n\n<p>D\u0131\u015fk\u0131daki histamin &lt;600 ng\/g (ELISA) ile laboratuvar referansl\u0131d\u0131r.<\/p>\n\n\n\n<p>Bu ama\u00e7la histamin olu\u015fturucular\u0131n k\u00fclt\u00fcrleri olu\u015fturulur. A\u015fa\u011f\u0131dakiler i\u00e7in referans de\u011ferler<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Hafnia alvia<\/li>\n\n\n\n<li>Klebsiella pneumonieae<\/li>\n\n\n\n<li>Morganella morgani<\/li>\n<\/ul>\n\n\n\n<p>her biri &lt;= 1 x 10<sup>6<\/sup>.<\/p>\n\n\n\n<p>(<a href=\"https:\/\/www.imd-berlin.de\/fachinformationen\/diagnostikinformationen\/300-399\/350-ursachendiagnostik-bei-erhoehten-histaminspiegeln-im-blut\" target=\"_blank\" rel=\"noreferrer noopener\">Kaynak<\/a>)<\/p>","protected":false},"excerpt":{"rendered":"<p><span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Okuma s\u00fcresi<\/span> <span class=\"rt-time\"> 4<\/span> <span class=\"rt-label rt-postfix\">dakika<\/span><\/span>Histamin ve histamin intolerans\u0131 (HIT) - a\u015fa\u011f\u0131da daha ayr\u0131nt\u0131l\u0131 olarak ele al\u0131nacak heyecan verici bir konu. Alerji hastalar\u0131, \u00f6rne\u011fin saman nezlesi hastalar\u0131, polen zamanlar\u0131nda alerjik semptomlardan kurtulmay\u0131 sa\u011flayan antihistaminiklere a\u015finad\u0131r. Ancak, v\u00fccutta histamin salg\u0131lanmas\u0131na ve histamin fazlal\u0131\u011f\u0131na yol a\u00e7abilen sadece polen de\u011fildir; diyet veya histamin \u00fcretimi eksikli\u011fi gibi di\u011fer fakt\u00f6rler de ...&nbsp;<a href=\"https:\/\/csiag.eu\/tr\/blog\/2024\/02\/27\/histamin-und-histamin-intoleranz-hit\/\" rel=\"bookmark\">Daha fazlas\u0131n\u0131 oku \"<span class=\"screen-reader-text\">Histamin ve histamin intolerans\u0131 (HIT)<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[3051,3052,1078,354],"tags":[3082,413,3152,3121,3077,3148,3056,3055,94,3126,3094,3080,3061,3127,3117,3062,3104,3158,3078,1341,3120,3111,1103,3129,3075,3118,3071,3065,3095,1637,3099,3100,3084,3114,3130,3064,3112,1989,3081,3155,1446,3128,3076,140,3147,3057,3050,3054,3135,3134,3136,3137,3072,3079,3053,3063,3140,3101,3141,3122,3116,3156,3086,3085,3087,3139,3115,3093,1344,3154,2204,139,3106,3149,3068,3132,3067,3150,3113,3151,3119,3138,3157,3103,3088,3069,1763,3102,3109,3125,3089,3090,3083,3146,3133,3091,3060,3059,3124,3123,3098,90,3142,3143,3092,3108,3107,3110,3144,3066,3153,3145,1101,3105,1098,3073,3074,3159,2011,3096,3097,3070],"class_list":["post-6701","post","type-post","status-publish","format-standard","hentry","category-histamin","category-hit","category-medizin","category-medizin-gesundheit","tag-acetylcholin","tag-aktivierung","tag-aktvitaetsmangel","tag-aldehydoxidase","tag-aminosaeure","tag-angst","tag-antihistaminika","tag-antihistaminikum","tag-antikoerper","tag-atemnot","tag-aetherische-oele","tag-basophile","tag-biosysnthese","tag-blutdruckabfall","tag-blutgefaesse","tag-bronchien","tag-darm","tag-darmepithelien","tag-decarboxylierung","tag-depressionen","tag-diaminoxidase","tag-dopamin","tag-durchfall","tag-dysregulation","tag-enzym","tag-eosionpihle","tag-epidermis","tag-ernaehrung","tag-ethanol","tag-freisetzung","tag-g-protein","tag-g-proteine","tag-gastrin","tag-gefssdilatation","tag-gehrinstoffwechsel","tag-gewegshormon","tag-glutamin","tag-granulozyten","tag-grnulozyten","tag-hafnia-alvia","tag-haut","tag-hautroetungen","tag-heparin","tag-herz","tag-herzrhythmusstoerung","tag-heuschnupfen","tag-histamin","tag-histamin-intoleranz","tag-histaminarm","tag-histaminreich","tag-histaminsenkend","tag-histaminsteigernd","tag-histidin","tag-histidindecarboxylase","tag-hit","tag-hormon","tag-hyperhidrose","tag-hypothalamus","tag-hypotonie","tag-imidazolylessigsaeure","tag-juckreiz","tag-klebsiella-pneumonieae","tag-komplementfaktor","tag-komplementfaktoren","tag-komplementsystem","tag-konjunktivitis","tag-kontraktion","tag-kontrastmittel","tag-kopfschmerzen","tag-kultur","tag-kupfer","tag-lunge","tag-magensaeure","tag-magensaeurespiegel","tag-magenschleimhaut","tag-mao-hemmer","tag-mastzelle","tag-mastzellenaktivierbarkeit","tag-mediator","tag-membranstabilitaet","tag-methyltransferase","tag-migraene","tag-morganella-morgani","tag-motilitaet","tag-muskelrelaxantien","tag-nervenzellen","tag-nesselsucht","tag-neurotransmitter","tag-noradrenalin","tag-ohnmacht","tag-opiat","tag-opiate","tag-pacap","tag-panikattacke","tag-plasma-spiegel","tag-plasmaexpander","tag-pollen","tag-pollenzeit","tag-referenzbereich","tag-refernzwert","tag-rezeptor","tag-rezeptoren","tag-rhinitis","tag-rhorrhea","tag-roentgenkontrastmittel","tag-schlagfrequenz","tag-schlagkraft","tag-serotonin","tag-sodbrennen","tag-speicherung","tag-stuhl","tag-tchykardie","tag-uebelkeit","tag-verdauungssystem","tag-vergiftung","tag-vesikel","tag-vesikeln","tag-vitamin-b6","tag-wasser","tag-zellebene","tag-zellmembra","tag-zns"],"modified_by":"Achim Goerner","_links":{"self":[{"href":"https:\/\/csiag.eu\/tr\/wp-json\/wp\/v2\/posts\/6701","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csiag.eu\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csiag.eu\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csiag.eu\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csiag.eu\/tr\/wp-json\/wp\/v2\/comments?post=6701"}],"version-history":[{"count":0,"href":"https:\/\/csiag.eu\/tr\/wp-json\/wp\/v2\/posts\/6701\/revisions"}],"wp:attachment":[{"href":"https:\/\/csiag.eu\/tr\/wp-json\/wp\/v2\/media?parent=6701"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csiag.eu\/tr\/wp-json\/wp\/v2\/categories?post=6701"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csiag.eu\/tr\/wp-json\/wp\/v2\/tags?post=6701"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}