{"id":10036,"date":"2025-06-02T19:05:44","date_gmt":"2025-06-02T19:05:44","guid":{"rendered":"https:\/\/csiag.eu\/?p=10036"},"modified":"2025-06-03T20:37:17","modified_gmt":"2025-06-03T20:37:17","slug":"%e5%8f%96%e5%86%b3%e4%ba%8e%e6%8c%82%e9%92%a9%e9%93%be%e9%95%bf%e5%ba%a6%e7%9a%84-lnp-%e7%9a%84%e6%af%92%e6%80%a7","status":"publish","type":"post","link":"https:\/\/csiag.eu\/zh\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/","title":{"rendered":"LNP \u7684\u6bd2\u6027\u53d6\u51b3\u4e8e PEG \u94fe\u7684\u957f\u5ea6"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_86 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u76ee\u5f55<\/p>\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/csiag.eu\/zh\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Welche_LNPs_wurden_verwendet\" >\u4f7f\u7528\u4e86\u54ea\u4e9b LNP\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/csiag.eu\/zh\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Toxizitat_wurde_nicht_durch_Studien_uberpruft\" >\u6bd2\u6027\u672a\u7ecf\u7814\u7a76\u9a8c\u8bc1<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/csiag.eu\/zh\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Akkumulation_in_der_Leber\" >\u809d\u810f\u4e2d\u7684\u79ef\u7d2f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/csiag.eu\/zh\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/#Der_Weg_in_die_Leber_und_die_Lange_der_Kette\" >\u8fdb\u5165\u809d\u810f\u7684\u8def\u5f84\u548c\u94fe\u6761\u7684\u957f\u5ea6<\/a><\/li><\/ul><\/nav><\/div>\n<span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">\u9605\u8bfb\u65f6\u95f4<\/span> <span class=\"rt-time\"> 2<\/span> <span class=\"rt-label rt-postfix\">\u5206\u949f<\/span><\/span>\n<p class=\"wp-block-paragraph\">PEG \u94fe\uff08\u805a\u4e59\u4e8c\u9187\uff09\u8d8a\u77ed\uff0cLNP \u7684\u6bd2\u6027\u5c31\u8d8a\u9ad8\u3002BioNTech \u5728\u5176 <a href=\"https:\/\/www.mdpi.com\/2227-9059\/9\/5\/530\" target=\"_blank\" rel=\"noreferrer noopener\">\u51fa\u7248\u7269<\/a> 2021 \u5e74 5 \u6708 10 \u65e5\u7684 \"LNP-mRNA \u7684\u975e\u514d\u75ab\u7597\u6cd5\u5e94\u7528\uff1a\u6700\u5927\u9650\u5ea6\u5730\u63d0\u9ad8\u7597\u6548\u548c\u5b89\u5168\u6027\"\uff0c\u5c3d\u7ba1\u63aa\u8f9e\u7565\u6709\u4e0d\u540c\uff1a\"\u6700\u5927\u9650\u5ea6\u5730\u63d0\u9ad8\u7597\u6548\"\u3002<br>\u8fd9\u79cd\u6bd2\u6027\u662f\u7531\u4e8e\u6240\u6709\u4e09\u79cd\u53ef\u7535\u79bb\u9633\u79bb\u5b50\u8102\u7c7b\u90fd\u4e0d\u53ef\u751f\u7269\u964d\u89e3\uff0c\u5b83\u4eec\u5728\u4f53\u5185\u7684\u7d2f\u79ef\u4e0d\u53ef\u907f\u514d\u5730\u4f1a\u4ea7\u751f\u7ec6\u80de\u6bd2\u6027\u540e\u679c\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Welche_LNPs_wurden_verwendet\"><\/span>\u4f7f\u7528\u4e86\u54ea\u4e9b LNP\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><em>\u8f89\u745e<\/em> \/ <em>\u751f\u7269\u6280\u672f<\/em> - BNT162b2 - <a href=\"https:\/\/www.echelon-inc.com\/product\/alc-0315\/\" target=\"_blank\" rel=\"noreferrer noopener\">ALC-0315<\/a> (\u53ef\u7535\u79bb\uff09\u548c <a href=\"https:\/\/www.echelon-inc.com\/product\/alc-0159\/\" target=\"_blank\" rel=\"noreferrer noopener\">ALC-0159<\/a> (\u805a\u4e59\u4e8c\u9187\u5316\uff09<br><em>\u73b0\u4ee3<\/em> - <a href=\"https:\/\/www.echelon-inc.com\/product\/sm-102\/\" target=\"_blank\" rel=\"noreferrer noopener\">SM-102<\/a> (\u53ef\u7535\u79bb\uff09\u548c <a href=\"https:\/\/www.echelon-inc.com\/product\/dmg-peg-2000\/\" target=\"_blank\" rel=\"noreferrer noopener\">PEG2000-DMG<\/a> (\u805a\u4e59\u4e8c\u9187\u5316\uff09<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"562\" src=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-1024x562.png\" alt=\"\" class=\"wp-image-10045\" srcset=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-1024x562.png 1024w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-300x165.png 300w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-768x421.png 768w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-18x10.png 18w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image.png 1456w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u5bf9\u4e8e\u4e0a\u8ff0\u6240\u6709\u8102\u8d28\uff0c\u5236\u9020\u5546\uff08\u5982 <a href=\"https:\/\/www.echelon-inc.com\/product\/alc-0315\/#tab-description\" target=\"_blank\" rel=\"noreferrer noopener\">\u57c3\u65bd\u6717\u751f\u7269\u79d1\u5b66\u516c\u53f8<\/a>) \"......\u8fd9\u662f\u8bd5\u5242\u7ea7\u4ea7\u54c1\uff0c\u4ec5\u4f9b\u7814\u7a76\u4f7f\u7528\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Toxizitat_wurde_nicht_durch_Studien_uberpruft\"><\/span>\u6bd2\u6027\u672a\u7ecf\u7814\u7a76\u9a8c\u8bc1<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u6839\u636e <a href=\"https:\/\/www.tga.gov.au\/sites\/default\/files\/foi-2389-06.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">\u51fa\u7248\u7269<\/a> \u6fb3\u5927\u5229\u4e9a\u653f\u5e9c\u536b\u751f\u90e8 2021 \u5e74 1 \u6708\u53d1\u5e03\u7684 \"BNT 162b2 mRNA COVID-19 \u75ab\u82d7 COMIRNATY\u2122 \u975e\u4e34\u5e8a\u8bc4\u4f30\u62a5\u544a \"\u7b2c 11 \u9875\u663e\u793a\uff1a\"\u672a\u5355\u72ec\u5bf9 LNP \u5236\u5242\u6216\u65b0\u578b\u8f85\u6599\u7684\u6bd2\u6027\u8fdb\u884c\u4e13\u95e8\u7814\u7a76\"\u3002<br>\u6362\u53e5\u8bdd\u8bf4\uff0c\u5c1a\u672a\u5bf9\u4e0a\u8ff0\u65b0\u578b LNP \u8f85\u6599\u7684\u4f7f\u7528\u548c\u5f71\u54cd\u8fdb\u884c\u6bd2\u6027\u7814\u7a76\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Akkumulation_in_der_Leber\"><\/span>\u809d\u810f\u4e2d\u7684\u79ef\u7d2f<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u8bb8\u591a\u836f\u7269\u4f1a\u90e8\u5206\u6216\u5168\u90e8\u7ecf\u809d\u810f\u4ee3\u8c22\u5e76\u8fdb\u5165\u8840\u6db2\u3002\u4e0a\u8ff0\u8f85\u6599 ALC-315 \u4e5f\u4f1a\u5728\u809d\u810f\u4e2d\u84c4\u79ef\uff0c\u8fd9\u4e00\u70b9\u53ef\u4ee5\u4ece <a href=\"https:\/\/www.judicialwatch.org\/wp-content\/uploads\/2022\/03\/JW-v-HHS-prod-3-02418.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">\u5bf9\u7b2c 2021-4379 \u53f7\u95ee\u9898\u7684\u90e8\u5206\u7b54\u590d<\/a> \u6839\u636e\u300a\u4fe1\u606f\u81ea\u7531\u6cd5\u300b(FOIA)\uff0c\u8fd9\u662f\u53f8\u6cd5\u89c2\u5bdf\u516c\u53f8\u8bc9\u7f8e\u56fd\u536b\u751f\u4e0e\u516c\u4f17\u670d\u52a1\u90e8\u6848(21-cv-2418)\u7684\u7533\u8bc9\u4e3b\u9898\uff0c\u76ee\u524d\u6b63\u5728\u7f8e\u56fd\u54e5\u4f26\u6bd4\u4e9a\u7279\u533a\u5730\u65b9\u6cd5\u9662\u5f85\u5ba1\uff0c\u89c1\u7b2c 466 \u9875\u4e2d\u7684\u7b2c 16 \u9875\uff1a<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"542\" src=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-1024x542.png\" alt=\"\" class=\"wp-image-10054\" srcset=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-1024x542.png 1024w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-300x159.png 300w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-768x407.png 768w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3-18x10.png 18w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-3.png 1212w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e0a\u8ff0\u62a5\u544a\u7b2c 45 \u9875\u4e5f\u6709\u63d0\u53ca\u3002 <a href=\"https:\/\/www.tga.gov.au\/sites\/default\/files\/foi-2389-06.pdf\" target=\"_blank\" rel=\"noopener\">\u62a5\u544a<\/a>:<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"55\" src=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-1024x55.png\" alt=\"\" class=\"wp-image-10060\" srcset=\"https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-1024x55.png 1024w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-300x16.png 300w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-768x42.png 768w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4-18x1.png 18w, https:\/\/csiag.eu\/wp-content\/uploads\/2025\/06\/image-4.png 1218w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u7b2c 46 \u9875\u4e2d\uff0c\u6839\u636e\u4f53\u5916\u5b9e\u9a8c\u6982\u8ff0\u4e86\u7eaf\u7406\u8bba\u5047\u8bbe\u7684\u4ee3\u8c22\u9014\u5f84\uff0c\u5c3d\u7ba1\u8fd9\u5c1a\u672a\u5728\u4eba\u4f53\u4e2d\u5f97\u5230\u9a8c\u8bc1\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u540c\u65f6 <a href=\"https:\/\/www.statnews.com\/2017\/01\/10\/moderna-trouble-mrna\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u73b0\u4ee3<\/a> \u7531\u4e8e\u4e0e\u809d\u810f\u4e0d\u76f8\u5bb9\uff0cALC-0315 \u505c\u4ea7\uff0c\u5e76\u81ea\u884c\u5f00\u53d1\u4e86 SM \u5e73\u53f0\uff08ALC-0315 \u88ab\u8bc1\u660e\u5bf9\u809d\u75c5 Crigler-Najjar \u7efc\u5408\u5f81\u7684\u57fa\u56e0\u6cbb\u7597\u6bd2\u6027\u592a\u5927\uff0c\u56e0\u6b64\u5f53\u65f6\u7684\u7814\u7a76\u5408\u4f5c\u4f19\u4f34 <em>Alexion<\/em> \u51fa\u4e8e\u5b89\u5168\u539f\u56e0\u505c\u6b62\u4e86\u7814\u7a76\uff09\uff0c\u4f46 BioNTech \/ \u8f89\u745e\u516c\u53f8\u5374\u8fdd\u80cc\u81ea\u5df1\u7684\u5224\u65ad\uff0c\u7ee7\u7eed\u4f7f\u7528\u8fd9\u4e9b\u836f\u7269\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Der_Weg_in_die_Leber_und_die_Lange_der_Kette\"><\/span>\u8fdb\u5165\u809d\u810f\u7684\u8def\u5f84\u548c\u94fe\u6761\u7684\u957f\u5ea6<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">... \u5c06\u7ee7\u7eed...<\/p>","protected":false},"excerpt":{"rendered":"<p><span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">\u9605\u8bfb\u65f6\u95f4<\/span> <span class=\"rt-time\"> 2<\/span> <span class=\"rt-label rt-postfix\">\u5206\u949f<\/span><\/span>Je k\u00fcrzer die PEG-Kette (Polyethylenglycol), desto h\u00f6her die Toxizit\u00e4t der LNP. Dies erkl\u00e4rt BioNTech in seiner Ver\u00f6ffentlichung &#8222;Non-Immunotherapy Application of LNP-mRNA: Maximizing Efficacy and Safety&#8220; vom 10.05.2021, wenn auch &#8211; etwas &#8211; anders formuliert: &#8222;Maximizing Efficacy&#8220;.Die Toxizit\u00e4t beruht auf der Tatsache, dass alle drei der ionisierbaren kationischen Lipide nicht biologisch abbaubar sind und ihre, damit&hellip;&nbsp;<a href=\"https:\/\/csiag.eu\/zh\/blog\/2025\/06\/02\/toxizitaet-der-lnp-in-abhaengigkeit-der-laenge-der-peg-kette\/\" rel=\"bookmark\">\u9605\u8bfb\u66f4\u591a \u00bb<span class=\"screen-reader-text\">LNP \u7684\u6bd2\u6027\u53d6\u51b3\u4e8e PEG \u94fe\u7684\u957f\u5ea6<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[628,316,1078],"tags":[5067,5066,5074,22,36,5080,5079,5069,5075,5071,4812,105,5073,5077,5070,5072,23,5076,5078,44],"class_list":["post-10036","post","type-post","status-publish","format-standard","hentry","category-corona","category-corona-blog","category-medizin","tag-alc-159","tag-alc-315","tag-alnylam","tag-biontech","tag-bnt162b2","tag-cholesterol","tag-dlin-mc3-dma","tag-dmg-peg2000","tag-elasomeran","tag-ionisierbar","tag-lnp","tag-moderna","tag-patisiran","tag-peg-lipid","tag-peg2000-dmg","tag-pegyliert","tag-pfizer","tag-phosholipid","tag-sterol","tag-tozinameran"],"modified_by":"Achim Goerner","_links":{"self":[{"href":"https:\/\/csiag.eu\/zh\/wp-json\/wp\/v2\/posts\/10036","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csiag.eu\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csiag.eu\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csiag.eu\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csiag.eu\/zh\/wp-json\/wp\/v2\/comments?post=10036"}],"version-history":[{"count":0,"href":"https:\/\/csiag.eu\/zh\/wp-json\/wp\/v2\/posts\/10036\/revisions"}],"wp:attachment":[{"href":"https:\/\/csiag.eu\/zh\/wp-json\/wp\/v2\/media?parent=10036"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csiag.eu\/zh\/wp-json\/wp\/v2\/categories?post=10036"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csiag.eu\/zh\/wp-json\/wp\/v2\/tags?post=10036"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}