{"id":12268,"date":"2026-01-17T19:28:26","date_gmt":"2026-01-17T19:28:26","guid":{"rendered":"https:\/\/csiag.eu\/?p=12268"},"modified":"2026-04-13T15:35:04","modified_gmt":"2026-04-13T15:35:04","slug":"%e9%92%88%e5%af%b9%e9%98%bf%e6%8b%89%e6%82%a3%e8%80%85%e7%9a%84%e5%8c%85%e8%99%ab%e7%97%85%e6%b2%bb%e7%96%97-%e6%8a%97%e7%94%9f%e7%b4%a0%e8%80%90%e8%8d%af%e6%80%a7%e8%8e%b1%e5%a7%86%e5%85%b3%e8%8a%82","status":"publish","type":"post","link":"https:\/\/csiag.eu\/zh\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/","title":{"rendered":"\u83b1\u59c6\u75c5--ARLA\uff08\u6297\u751f\u7d20\u8010\u836f\u6027\u83b1\u59c6\u5173\u8282\u708e\uff09\u60a3\u8005\u7684\u6000\u5c14\u7597\u6cd5"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u76ee\u5f55<\/p>\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#Pathogenese\" >\u53d1\u75c5\u673a\u5236<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#Herkommliche_Therapieformen\" >\u4f20\u7edf\u6cbb\u7597\u65b9\u5f0f<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#NSAR\" >\u975e\u753e\u4f53\u6297\u708e\u836f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#DMARD\" >DMARD<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#Beispiel_ARLA-Patient_%E2%80%93_NSARs_und_DMARD\" >ARLA \u60a3\u8005\u793a\u4f8b--\u975e\u753e\u4f53\u6297\u708e\u836f\u548c DMARDs<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#Biologika\" >\u751f\u7269\u5236\u5242<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#Huaier-Pilz_%E2%80%93_eine_Alternative\" >\u6000\u5c14\u83c7--\u66ff\u4ee3\u54c1\uff1f<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#NF-%CE%BAB-Pathway-Hemmung_Plasma-Membran-Signalisierung\" >NF-\u03baB \u901a\u8def\u6291\u5236\uff08\u8d28\u819c\u4fe1\u53f7\u4f20\u5bfc\uff09<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#JAKSTAT-Pathway-Modulation_Endosomal-Signalisierung_IL-6-Feedback\" >JAK\/STAT \u901a\u8def\u8c03\u8282\uff08\u5185\u4f53\u4fe1\u53f7 + IL-6 \u53cd\u9988\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#Vergleich_JAK1i_wie_Upadacitinib_vs_Huaier\" >\u6bd4\u8f83\uff1aJAK1i\uff08\u5982 upadacitinib\uff09\u4e0e\u6000\u5c14\uff1a<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#PI3KAKT-Aktivierung_Mitochondriale_Restoration_Treg-Support\" >PI3K\/AKT \u6fc0\u6d3b\uff08\u7ebf\u7c92\u4f53\u6062\u590d+Treg \u652f\u6301\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#Spezifische_Effekte_bei_ARLA\" >ARLA \u7684\u5177\u4f53\u6548\u679c\uff1a<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#Ribosomale_Homoostase_Tanaka-Hauptfund\" >\u6838\u7cd6\u4f53\u5e73\u8861\uff08\u7530\u4e2d\u7684\u4e3b\u8981\u53d1\u73b0\uff09<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#Mechanistischer_Vergleich_Huaier_zu_Biologika\" >\u6000\u5c14\u4e0e\u751f\u7269\u5236\u5242\u7684\u673a\u7406\u6bd4\u8f83<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#Dosierungsempfehlung_bei_ARLA_im_fortgeschrittenen_Stadium\" >Dosierungsempfehlung bei ARLA im fortgeschrittenen Stadium<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#Vorschlag_fur_ARLA-Dosierung\" >\u5173\u4e8e ARLA \u914d\u6599\u7684\u5efa\u8bae<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/#Weitere_relevante_Beitrage_zum_Anwendungsbereich_des_Huaier-Pilzes\" >\u5173\u4e8e\u6000\u5c14\u83c7\u9002\u7528\u8303\u56f4\u7684\u5176\u4ed6\u76f8\u5173\u6761\u6b3e<\/a><\/li><\/ul><\/nav><\/div>\n<span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">\u9605\u8bfb\u65f6\u95f4<\/span> <span class=\"rt-time\"> 18<\/span> <span class=\"rt-label rt-postfix\">\u5206\u949f<\/span><\/span>\n<p>\u83b1\u59c6\u75c5\u7684\u75c5\u56e0\u662f <em>Borrelia burgdorferi<\/em>, \u4e00\u79cd\u87ba\u65cb\u5f62\u7ec6\u83cc\uff0c\u53ef\u4ee5 <em>\u83b1\u59c6\u5305\u866b\u75c5 <\/em>(\u53c8\u79f0\u83b1\u59c6\u75c5\uff09\u3002.<\/p>\n\n\n\n<p>\u5b83\u662f\u4e3a\u6570\u4e0d\u591a\u7684\u5177\u6709\u79d1\u5b66\u9b45\u529b\u7684\u75c5\u539f\u4f53\u4e4b\u4e00\uff0c\u540c\u65f6\u4e5f\u662f\u514d\u75ab\u5b66\u548c\u4e34\u5e8a\u5b9e\u8df5\u4e2d\u6700\u68d8\u624b\u7684\u7ec6\u83cc\u611f\u67d3\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u4e0d\u5bfb\u5e38\u7684\u9057\u4f20\u5b66<\/strong> \u7ebf\u6027\u67d3\u8272\u4f53\u548c\u590d\u5408\u8d28\u7c92\u7cfb\u7edf<\/li>\n\n\n\n<li><strong>\u514d\u75ab\u5165\u4fb5\u5927\u5e08<\/strong> VlsE \u6297\u539f\u53d8\u5f02\u3001\u8865\u4f53\u6291\u5236\u3001\u751f\u7269\u819c<\/li>\n\n\n\n<li><strong>\u591a\u5668\u5b98\u75c5\u539f\u4f53<\/strong> \u53ef\u5f71\u54cd\u51e0\u4e4e\u6240\u6709\u5668\u5b98\u7cfb\u7edf<\/li>\n\n\n\n<li><strong>\u575a\u6301\u4e0d\u61c8\u7684\u4e13\u5bb6\uff1a<\/strong> \u53ef\u5bfc\u81f4\u6301\u7eed\u6570\u5e74\u7684\u6162\u6027\u611f\u67d3<\/li>\n\n\n\n<li><strong>TLR2 \u4f18\u52bf\uff1a<\/strong> \u5f15\u53d1\u5927\u89c4\u6a21\u708e\u75c7\uff08\u8d85\u8fc7 Toll \u6837\u53d7\u4f53 4\uff09<\/li>\n\n\n\n<li><strong>\u81ea\u8eab\u514d\u75ab\u6f5c\u80fd<\/strong> \u5bfc\u81f4\u611f\u67d3\u540e\u81ea\u8eab\u514d\u75ab (ARLA)<\/li>\n<\/ul>\n\n\n\n<p>\u5927\u591a\u6570\u83b1\u59c6\u5173\u8282\u708e\u60a3\u8005\u5728\u63a5\u53d7\u6297\u751f\u7d20\u6cbb\u7597\u540e\u90fd\u4f1a\u75ca\u6108\u3002\u7136\u800c\uff0c\u5927\u7ea6\u6709 10% \u7684\u4eba\u5bf9\u8fd9\u79cd\u6cbb\u7597\u65b9\u6cd5\u6ca1\u6709\u53cd\u5e94\uff0c\u5e76\u53d1\u5c55\u6210\u6240\u8c13\u7684\u83b1\u59c6\u5173\u8282\u708e\u3002. <strong>\u6297\u751f\u7d20\u8010\u836f\u6027\u83b1\u59c6\u5173\u8282\u708e<\/strong> (<em>ARLA<\/em>).<\/p>\n\n\n\n<p>\u8fd9\u4e9b 10% \u5206\u4e3a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>50% \u5728 x \u5e74\u5185\u51fa\u73b0\u81ea\u53d1\u7f13\u89e3\uff08\u75be\u75c5\u75c7\u72b6\u6682\u65f6\u6216\u6c38\u4e45\u7f13\u89e3\uff09\u3002<\/li>\n\n\n\n<li>30% \u81f3 <strong>DMARD<\/strong> (\u75be\u75c5\u8c03\u8282\u6297\u98ce\u6e7f\u836f\u7269\uff09\/ <strong>\u751f\u7269\u5236\u5242<\/strong> (<strong>\u9488\u5bf9\u7279\u5b9a\u76ee\u6807\u7ed3\u6784<\/strong> \u514d\u75ab\u7cfb\u7edf)<\/li>\n\n\n\n<li>20% \u6162\u6027\u548c\u8010\u836f\u6027<\/li>\n<\/ul>\n\n\n\n<p>\u9996\u5148\u4ecb\u7ecd\u4e86\u53d1\u75c5\u673a\u7406\uff08\u75c5\u56e0\uff09\u3001\u4f20\u7edf\u6cbb\u7597\u65b9\u6848\uff0c\u7136\u540e\u4ecb\u7ecd\u4e86\u4f7f\u7528\u6000\u5c14\u771f\u83cc\u6709\u6548\u6210\u5206\u7684\u6cbb\u7597\u65b9\u6cd5\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Pathogenese\"><\/span>\u53d1\u75c5\u673a\u5236<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><strong>\u76f4\u63a5\u5165\u4fb5\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u901a\u8fc7 DbpA\/B \u4e0e\u80f6\u539f\u86cb\u767d\/\u8715\u76ae\u86cb\u767d\u7ed3\u5408--\uff08\u4f7f\u75c5\u539f\u4f53\u80fd\u591f\u9644\u7740\u5728\u5bcc\u542b\u80f6\u539f\u86cb\u767d\u7684\u7ed3\u6784\u4e0a\uff0c\u8fd9\u5bf9\u75c5\u539f\u4f53\u5b9e\u9645\u5165\u4fb5\u5bbf\u4e3b\u548c\u5728\u5bbf\u4e3b\u4f53\u5185\u5b9a\u6b96\u975e\u5e38\u91cd\u8981\uff09<\/li>\n\n\n\n<li>\u901a\u8fc7 BBK32 \u4e0e\u7ea4\u7ef4\u7c98\u8fde\u86cb\u767d\u7ed3\u5408--\uff08\u6839\u636e\u673a\u68b0\u8d1f\u8377\uff08\u5982\u5728\u8840\u6db2\u4e2d\uff09\uff0c\u901a\u8fc7\u5f62\u6210\u805a\u5408\u7ea4\u7ef4\u7c98\u8fde\u86cb\u767d\uff0c\u52a8\u6001\u52a0\u5f3a\u75c5\u539f\u4f53\u7684\u7ed3\u5408\u80fd\u529b\uff1a\u8d8a\u9ad8\uff0c\u8d8a\u5f3a\uff09 <\/li>\n\n\n\n<li>\u514d\u75ab\u53cd\u5e94\u5f15\u53d1\u7684\u95f4\u63a5\u7ec4\u7ec7\u635f\u4f24<\/li>\n<\/ul>\n\n\n\n<p><strong>\u514d\u75ab\u89e6\u53d1\uff08TLR2 \u4e3b\u5bfc\uff09\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8868\u9762\u8102\u86cb\u767d\uff08OspA\u3001OspC\u3001OspE\uff09<\/strong> \u2192 TLR2\/6 \u6fc0\u6d3b\uff08\u65e9\u671f\u514d\u75ab\u53cd\u5e94\uff0c\u4f46\u4e5f\u4e0e\u53d1\u75c5\u673a\u5236\u6709\u5173\uff0c\u56e0\u4e3a\u5b83\u4eec\u4f1a\u5f15\u53d1\u8fc7\u5ea6\u7684\u708e\u75c7\u53cd\u5e94\uff09<\/li>\n\n\n\n<li><strong>\u80bd\u805a\u7cd6<\/strong> \u2192 TLR2 \u6fc0\u6d3b\uff08\u5bfc\u81f4\u5f3a\u70c8\u7684\u708e\u75c7\u53cd\u5e94\u5e76\u6fc0\u6d3b\u5148\u5929\u6027\u548c\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\uff09<\/li>\n\n\n\n<li>\u5bfc\u81f4\u5927\u89c4\u6a21 <strong>NF-\u03baB\/MAPK \u6fc0\u6d3b<\/strong> (\u5bfc\u81f4\u5f3a\u70c8\u91ca\u653e&nbsp;<strong>\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50<\/strong>&nbsp;\u559c\u6b22 <strong>TNF-\u03b1\u3001IL-6 \u548c IL-1\u03b2<\/strong>, \u4f1a\u52a0\u5267\u83b1\u59c6\u75c5\u7684\u708e\u75c7\u53cd\u5e94\uff09\u3002<\/li>\n\n\n\n<li>\u5927\u89c4\u6a21 <strong>\u4ea7\u751f\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50<\/strong><\/li>\n<\/ul>\n\n\n\n<p><strong>\u514d\u75ab\u5165\u4fb5\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8865\u4f53\u6291\u5236<\/strong><br><em>OspE\u3001OspF<\/em> - \u7ec6\u83cc\u7684\u8868\u9762\u86cb\u767d\u4e0e\u8865\u4f53\u7cfb\u7edf\u7684\u8c03\u8282\u86cb\u767d H \u7ed3\u5408\uff0c\u4ece\u800c\u963b\u6b62\u4e86\u8865\u4f53\u7684\u6fc0\u6d3b\uff0c\u5426\u5219\u8865\u4f53\u5c31\u4f1a\u6467\u6bc1\u7ec6\u83cc\u3002.<br>OspF \u4f3c\u4e4e\u5728\u8731\u866b\u5bf9\u81ea\u8eab\u75c5\u539f\u4f53\u7684\u81ea\u6211\u4fdd\u62a4\u4e2d\u53d1\u6325\u4e86\u4f5c\u7528\uff1a\u7528 OspF \u514d\u75ab\u7684\u5c0f\u9f20\u4f53\u5185\u87ba\u65cb\u4f53\u7684\u51cf\u5c11\u91cf\u9ad8\u8fbe 90%\u3002\u8d44\u6599\u6765\u6e90<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC186469\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u90e8\u5206\u6d88\u706d\u566c\u54ac OspE \u6216 OspF \u514d\u75ab\u5c0f\u9f20\u7684\u8731\u4f53\u5185\u7684\u5305\u67d4\u6c0f\u83cc<\/a>)<\/li>\n\n\n\n<li><strong>\u6297\u539f\u53d8\u5f02<\/strong><br><em>VlsE - \u53ef\u53d8\u4e3b\u8981\u86cb\u767d\u6837\u5e8f\u5217 \u5df2\u8868\u8fbe<\/em> &#8211; verhindert Erkennung durch das Immunsystem<\/li>\n\n\n\n<li><strong>\u751f\u7269\u819c\u7684\u5f62\u6210<\/strong><br>selbst produzierte <em>\u7ec6\u80de\u5916\u805a\u5408\u7269\u8d28<\/em> zum Eigenschutz des Erregers<\/li>\n\n\n\n<li><strong>\u7ec6\u80de\u5185\u6301\u4e45\u6027<\/strong><br>in Spiroch\u00e4ten-Form-Varianten (Gruppe gramnegativer, schraubenf\u00f6rmiger, anaerob oder fakultativ anaerob lebender Bakterien, u.a. auch Syphilis- und Leptospirose-Erreger) m\u00f6glich, verstecken sich innerhalb der infizierten Zelle und k\u00f6nnen dort symptomlos \u00fcber Monate und Jahre verweilen<\/li>\n<\/ul>\n\n\n\n<p><strong>\u81ea\u8eab\u514d\u75ab\uff08\u611f\u67d3\u540e\uff09\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>OspA \u4e0e\u4eba\u7c7b\u86cb\u767d\u8d28\uff08\u5982 LFA-1\uff09\u4e4b\u95f4\u7684\u4ea4\u53c9\u53cd\u5e94<\/strong><br>molekulares Mimicry: f\u00fchrt zu einer&nbsp;autoimmunologisch aufrechterhaltenen Entz\u00fcndung, auch wenn der Erreger bereits eliminiert ist.<br>\u9057\u4f20\u6613\u611f\u60a3\u8005\u7684\u5f3a\u70c8 T \u7ec6\u80de\u53cd\u5e94\u4e0e\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\u7684\u8fc7\u5ea6\u5206\u6ccc\u6709\u5173\uff08\u5982\uff1a\u80f0\u5c9b\u7d20\uff09\u3002.&nbsp;<strong>TNF\u03b1\u3001IFN\u03b3<\/strong>) verbunden, die den Entz\u00fcndungsprozess aufrecht erh\u00e4lt<\/li>\n\n\n\n<li><strong>\u8868\u4f4d\u6269\u6563<\/strong><br>Nach anf\u00e4nglicher Immunreaktion gegen Borrelien-Antigene wie&nbsp;<strong>OspA<\/strong>&nbsp;\u6301\u7eed\u7684\u708e\u75c7\u4f1a\u5bfc\u81f4\u7ec4\u7ec7\u8150\u70c2\u548c\u4eba\u4f53\u81ea\u8eab\u86cb\u767d\u8d28\u7684\u91ca\u653e\u3002.<br>\u7136\u540e\uff0c\u8fd9\u4e9b\u8868\u4f4d\u4e5f\u4f1a\u88ab\u514d\u75ab\u7cfb\u7edf\u8bc6\u522b\u548c\u5448\u73b0\uff0c\u514d\u75ab\u53cd\u5e94\u7531\u6b64\u6269\u5c55\u5230\u65b0\u7684\u3001\u6700\u521d\u4e0d\u4f9d\u8d56\u4e8e\u5916\u6765\u6297\u539f\u7684\u8868\u4f4d\u3002\u8fd9\u4e00\u8fc7\u7a0b\u7684\u7279\u70b9\u662f\u7f3a\u4e4f\u8c03\u8282\u6027&nbsp;<strong>IL-10<\/strong>&nbsp;verst\u00e4rkt, was zu einer unkontrollierten Autoimmunit\u00e4t f\u00fchren kann.<\/li>\n\n\n\n<li><strong>\u6301\u4e45\u6027\u80bd\u805a\u7cd6\u5f15\u53d1\u81ea\u53cd\u5e94 T \u7ec6\u80de<\/strong><br>Bestandteile der bakteriellen Zellwand des Erregers k\u00f6nnen, auch nach erfolgreicher Antibiotikatherapie, in Geweben wie Leber oder in Gelenken vereilen und stimulieren weiterhin das Immunsystem. Zudem beeinflussen sie den&nbsp;Energiestoffwechsel von Immunzellen&nbsp;und f\u00f6rdern die Produktion entz\u00fcndungsf\u00f6rdernder Proteine, was wiederum die Autoimmunit\u00e4t verst\u00e4rkt<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Herkommliche_Therapieformen\"><\/span>\u4f20\u7edf\u6cbb\u7597\u65b9\u5f0f<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"NSAR\"><\/span>\u975e\u753e\u4f53\u6297\u708e\u836f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u975e\u753e\u4f53\u6297\u708e\u836f\uff08NSAIDs\uff09\u662f\u4e00\u79cd\u53ef\u4ee5\u6d88\u708e\u3001\u6b62\u75db\u548c\u9000\u70e7\u7684\u836f\u7269\uff0c\u4f46\u4e0e\u76ae\u8d28\u7c7b\u56fa\u9187\u4e0d\u540c\uff0c\u5b83\u4e0d\u662f\u7c7b\u56fa\u9187\u3002.<br>\u4e0e\u7c7b\u56fa\u9187\u76f8\u6bd4\uff0c\u975e\u753e\u4f53\u6297\u708e\u836f\u4e0d\u4f1a\u589e\u52a0\u611f\u67d3\u7387\u3002.<\/p>\n\n\n\n<p>\u5b83\u4eec\u80fd\u975e\u9009\u62e9\u6027\u5730\u6291\u5236\u4ea7\u751f\u524d\u5217\u817a\u7d20\u548c\u8840\u6813\u7d20\u7684 COX\uff08\u73af\u6c27\u5316\u9176\uff09-1 \u548c COX-2 \u9176\u3002.<br>COX-1 \u59cb\u7ec8\u5904\u4e8e\u6d3b\u8dc3\u72b6\u6001\uff08\u5982\u679c\u4e0d\u6d3b\u8dc3\u6216\u53d7\u5230\u6291\u5236\uff0c\u4f1a\u5bfc\u81f4\u80c3\u6e83\u75a1\u3001\u80be\u810f\u95ee\u9898\u548c\u51fa\u8840\u503e\u5411\u7b49\uff09\uff0c\u800c COX-2 \u5219\u5728\u708e\u75c7\u671f\u95f4\u4e0a\u8c03\u3002.<br>\u963b\u65ad COX-2 \u53ef\u4ea7\u751f\u9884\u671f\u6548\u679c\uff0c\u5982\u51cf\u8f7b\u708e\u75c7\u548c\u75bc\u75db\u3001\u9000\u70e7\u3002.<\/p>\n\n\n\n<p>\u7531\u4e8e\u975e\u9009\u62e9\u6027\u975e\u753e\u4f53\u6297\u708e\u836f\u5bf9\u4e24\u79cd\u9176\u7684\u6291\u5236\u4f5c\u7528\u76f8\u540c\uff0c\u56e0\u6b64\u4e5f\u4f1a\u4ea7\u751f\u4e0a\u8ff0\u4e0d\u826f\uff08\u526f\uff09\u5f71\u54cd\u3002.<\/p>\n\n\n\n<p><strong>\u975e\u753e\u4f53\u6297\u708e\u836f\u53ea\u6709\u5bf9\u75c7\u6548\u679c<\/strong>. .\u75c5\u539f\u4f53\u4ecd\u7136\u5b58\u5728\u5e76\u6d3b\u8dc3\uff0c\u708e\u75c7\u4ecb\u8d28\uff08\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\uff09\u7ee7\u7eed\u4e0d\u53d7\u963b\u788d\u5730\u4ea7\u751f\uff0c\u8f6f\u9aa8\u4fb5\u8680\u6709\u589e\u65e0\u51cf\u3002.<\/p>\n\n\n\n<p>\u975e\u9009\u62e9\u6027\u975e\u753e\u4f53\u6297\u708e\u836f\u6700\u5e38\u89c1\u7684\u6d3b\u6027\u6210\u5206\u662f<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4e59\u9170\u6c34\u6768\u9178<\/li>\n\n\n\n<li>\u53cc\u6c2f\u82ac\u9178<\/li>\n\n\n\n<li>\u5e03\u6d1b\u82ac<\/li>\n\n\n\n<li>\u5432\u54da\u7f8e\u8f9b<\/li>\n\n\n\n<li>\u916e\u6d1b\u82ac<\/li>\n\n\n\n<li>\u7f8e\u6d1b\u6614\u5eb7<\/li>\n\n\n\n<li>\u8418\u666e\u751f<\/li>\n\n\n\n<li>\u5421\u7f57\u6614\u5eb7<\/li>\n<\/ul>\n\n\n\n<p>\u6700\u5e38\u89c1\u7684\uff08COX-2\uff09\u6291\u5236\u5242\u7684\u9009\u62e9\u6027\u6d3b\u6027\u7269\u8d28\u6709<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u585e\u6765\u6614\u5e03<\/li>\n\n\n\n<li>\u4f9d\u6258\u8003\u6614<\/li>\n<\/ul>\n\n\n\n<p>\u7f57\u975e\u6614\u5e03\uff08\u7531\u4e8e\u4f1a\u589e\u52a0\u5fc3\u810f\u75c5\u53d1\u4f5c\u7684\u98ce\u9669\uff09\u548c\u4f10\u5730\u6614\u5e03\u5df2\u64a4\u51fa\u5e02\u573a\u3002.<\/p>\n\n\n\n<p>\u60a3\u6709\u51a0\u5fc3\u75c5\uff08CHD\uff09\u6216\u5fc3\u810f\u75c5\u53d1\u4f5c\u540e\u7684\u60a3\u8005\u4e0d\u80fd\u670d\u7528 COX-2 \u9009\u62e9\u6027\u975e\u753e\u4f53\u6297\u708e\u836f\uff0c\u56e0\u4e3a\u5b83\u4eec\u4f1a\u52a0\u91cd\u8fd9\u4e9b\u75be\u75c5\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"DMARD\"><\/span>DMARD<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>DMARD \u7c7b\u522b\u5305\u62ec\u4e0d\u4ec5\u80fd\u7f13\u89e3\u75c7\u72b6\u7684\u836f\u7269\uff08\u5982\u975e\u753e\u4f53\u6297\u708e\u836f\uff09\uff0c\u8fd8\u5305\u62ec <strong>\u79ef\u6781\u51cf\u7f13\u6216\u963b\u6b62\u75be\u75c5\u7684\u53d1\u5c55<\/strong> \u548c\u514d\u75ab\u7cfb\u7edf\u3002.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Beispiel_ARLA-Patient_%E2%80%93_NSARs_und_DMARD\"><\/span>ARLA \u60a3\u8005\u793a\u4f8b--\u975e\u753e\u4f53\u6297\u708e\u836f\u548c DMARDs<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u60a3\u8005\uff1a42 \u5c81\uff0c\u60a3\u6709 ARLA\uff08\u83b1\u59c6\u75c5\u540e\u819d\u5173\u8282\u5355\u5173\u8282\u708e\uff09\u3002<\/p>\n\n\n\n<p><strong>\u6700\u521d\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u8418\u666e\u751f 500 \u6beb\u514b\uff0c\u6bcf\u65e5 2 \u6b21<\/li>\n\n\n\n<li>\u5965\u7f8e\u62c9\u5511 20 \u6beb\u514b\uff0c\u6bcf\u5929\u4e00\u6b21\uff08\u4fdd\u62a4\u80c3\u90e8\uff09<\/li>\n<\/ul>\n\n\n\n<p>\u75bc\u75db 7\/10<br>\u5173\u8282\u79ef\u6db2 200 \u6beb\u5347<\/p>\n\n\n\n<p><strong>\u4e24\u5468\u540e<\/strong>:<\/p>\n\n\n\n<p>\u75bc\u75db 4\/10\uff08\u201e\u5e78\u798f\u611f \u201c\u66f4\u5f3a\uff09<br>\u5173\u8282\u79ef\u6db2\u4ecd\u6709 180 \u6beb\u5347 <br>\u80bf\u80c0\u51e0\u4e4e\u6ca1\u6709\u597d\u8f6c<\/p>\n\n\n\n<p><strong>\u5347\u7ea7\u4e3a DMARD\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>+\u7532\u6c28\u8776\u5464 15 \u6beb\u514b\/\u5468<\/li>\n<\/ul>\n\n\n\n<p>\u6216 <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>+ \u751f\u7269\u5236\u5242\uff08TNFi \u6216 JAKi\uff09<\/li>\n<\/ul>\n\n\n\n<p><strong>\u7efc\u5408\u6cbb\u7597 8-12 \u5468\u540e\uff1a<\/strong><\/p>\n\n\n\n<p>\u75bc\u75db 0-1\/10<br>\u5173\u8282\u79ef\u6db2 &lt; 50 \u6beb\u5347<br>\u6062\u590d\u884c\u52a8\u80fd\u529b<br>\u75c5\u60c5\u5f97\u5230\u7f13\u89e3\uff01<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Biologika\"><\/span>\u751f\u7269\u5236\u5242<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u751f\u7269\u5236\u5242\u662f\u4ee5\u4eba\u7c7b\u86cb\u767d\u8d28\u3001\u6838\u9178\u6216\u6297\u4f53\u4e3a\u6a21\u578b\u7528\u751f\u7269\u6280\u672f\u751f\u4ea7\u7684\u8f83\u5927\u5206\u5b50\uff0c\u7531\u4e8e\u4f1a\u88ab\u80c3\u9178\u8fc7\u65e9\u5206\u89e3\uff0c\u56e0\u6b64\u4e0d\u80fd\u4ee5\u7247\u5242\u5f62\u5f0f\u7ed9\u836f\uff0c\u53ea\u80fd\u4ee5\u76ae\u4e0b\u6ce8\u5c04\u6216\u8f93\u6db2\u5f62\u5f0f\u7ed9\u836f\u3002\u53ea\u6709 JAK \u6291\u5236\u5242\u53ef\u4ee5\u53e3\u670d\u3002.<br>\u5b83\u4eec\u53ef\u4ee5\u5bf9\u7ec6\u80de\u56e0\u5b50\u3001\u53d7\u4f53\u6216\u514d\u75ab\u7ec6\u80de\u4ea7\u751f\u8c03\u8282\u4f5c\u7528\u3002\u80f0\u5c9b\u7d20\u4e5f\u662f\u4e00\u79cd\uff081982 \u5e74\u9996\u521b\u7684\uff09\u751f\u7269\u5236\u5242\u3002.<\/p>\n\n\n\n<p>\u5728 ARLA \u8303\u7574\u5185\uff0c\u5b83\u4eec\u5206\u4e3a\u56db\u4e2a\u7b49\u7ea7<\/p>\n\n\n\n<p>\u7b2c\u4e00\u9009\u62e9 <strong>TNF-\u03b1 \u6291\u5236\u5242\uff08TNFi\uff09<\/strong> - \u4f7f\u7528 50-70% 4-8 \u5468\u540e\u51fa\u73b0\u53cd\u5e94<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u963f\u8fbe\u6728\u5355\u6297<\/li>\n\n\n\n<li>\u82f1\u592b\u5229\u897f\u5355\u6297<\/li>\n\n\n\n<li>\u4f9d\u90a3\u897f\u666e<\/li>\n<\/ul>\n\n\n\n<p>\u7b2c\u4e8c\u9009\u62e9 <strong>IL-6 \u6291\u5236\u5242\uff08IL-6i\uff09<\/strong> - 4-12\u5468\u540e\uff0c50-60%\u51fa\u73b0\u54cd\u5e94<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6258\u897f\u73e0\u5355\u6297<\/li>\n\n\n\n<li>\u6c99\u5229\u5355\u6297<\/li>\n<\/ul>\n\n\n\n<p>\u5bf9 TNFi \u65e0\u5e94\u7b54\u8005\uff08\u7ea6 30-50% \u7684\u60a3\u8005\uff09\u4e5f\u6709\u6548<\/p>\n\n\n\n<p>\u7b2c 3 \u4e2a\u9009\u62e9 <strong>JAK \u6291\u5236\u5242\uff08JAKi\uff09 <\/strong>- 2-4 \u5468\u540e\u5df2\u6709\u53cd\u5e94 - \u4ecd\u5728\u5f00\u53d1\u4e2d<br>\u5b83\u4eec\u963b\u65ad\u4e86 JAK1\uff08\u539f\u53d1\u6027\uff0c\u5f3a\uff09\u3001JAK2\uff08\u7ee7\u53d1\u6027\uff0c\u5f31\uff09\u548c TYK2\uff08\u7ee7\u53d1\u6027\uff0c\u5f31\uff09\uff0c\u8fd9\u5c31\u662f\u4e3a\u4ec0\u4e48 STAT3 \u65e0\u6cd5\u78f7\u9178\u5316\uff0c\u56e0\u800c\u4fdd\u6301\u4e0d\u6d3b\u8dc3\uff0c\u4f9d\u8d56 IL-6 \u7684\u57fa\u56e0\u65e0\u6cd5\u8f6c\u5f55\u3002\u53e6\u4e00\u65b9\u9762\uff0cJAK3 \u4e0d\u4f1a\u88ab\u963b\u65ad\uff0c\u8fd9\u5bf9\u63d0\u9ad8\u6297\u611f\u67d3\u80fd\u529b\u5177\u6709\u79ef\u6781\u610f\u4e49\uff08\u8d44\u6599\u6765\u6e90\uff1a\u5168\u6587\uff0c\u542b\u8d39\u7528\uff09\uff1a <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/312615\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u6162\u6027\u83b1\u59c6\u5173\u8282\u708e\u3002\u4e0e\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u7684\u4e34\u5e8a\u548c\u514d\u75ab\u9057\u4f20\u5b66\u533a\u5206<\/a>).<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4e4c\u8fbe\u66ff\u5c3c<\/li>\n\n\n\n<li>\u5df4\u5229\u66ff\u5c3c<\/li>\n\n\n\n<li>\u6258\u6cd5\u66ff\u5c3c<\/li>\n<\/ul>\n\n\n\n<p>\u7b2c 4 \u4e2a\u9009\u62e9 <strong>B \u7ec6\u80de\u6d88\u8017\u5242<\/strong> - 40-50%\u65f6\u7684\u5e94\u7b54--\u4ec5\u9488\u5bf9TNFi + IL-6i + JAKi\u65e0\u5e94\u7b54\u8005<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5229\u59a5\u6614\u5355\u6297<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Huaier-Pilz_%E2%80%93_eine_Alternative\"><\/span>\u6000\u5c14\u83c7--\u66ff\u4ee3\u54c1\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\"(\u300a\u4e16\u754c\u4eba\u6743\u5ba3\u8a00\u300b) <a href=\"https:\/\/aditum.org\/journals\/international-journal-of-medical-case-reports-and-medical-research\/archive\/967\" target=\"_blank\" rel=\"noreferrer noopener\">\u7530\u4e2d\u7814\u7a76<\/a> \u63ed\u793a\u4e86 Huaier \u7684\u6d3b\u6027\u6210\u5206\u4e3b\u8981\u5bf9\u5404\u79cd\u764c\u75c7\uff08\u8111\u7624\u9664\u5916\uff0c\u56e0\u4e3a\u5927\u5206\u5b50\u6d3b\u6027\u6210\u5206\u65e0\u6cd5\u901a\u8fc7\u8840\u8111\u5c4f\u969c\uff09\u7684\u4f5c\u7528\u3002.<br>\u6709\u4e00\u4e2a\u5355\u72ec\u7684 <a href=\"https:\/\/csiag.eu\/zh\/%e6%b7%ae%e5%b0%94%e8%8f%87%e5%9c%a8%e7%99%8c%e7%97%87%e6%b2%bb%e7%96%97%e4%b8%ad%e7%9a%84%e5%ba%94%e7%94%a8\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u6350\u6b3e<\/a>, \u8fd8\u6709 <a href=\"https:\/\/csiag.eu\/zh\/%e6%b7%ae%e5%b0%94%e8%8f%87%e5%9c%a8%e7%99%8c%e7%97%87%e6%b2%bb%e7%96%97%e4%b8%ad%e7%9a%84%e5%ba%94%e7%94%a8\/#Dosierungsempfehlung\" target=\"_blank\" rel=\"noreferrer noopener\">\u5242\u91cf\u8bf4\u660e<\/a> \u548c <a href=\"https:\/\/nutrimentas-shop.de\/products\/vitalpilz-huaier-trametes-robiniophila-fur-wissenschaftliche-zwecke\" target=\"_blank\" rel=\"noreferrer noopener\">\u4f9b\u5e94\u6765\u6e90<\/a> \u7814\u7a76\u4e2d\u4f7f\u7528\u7684\u9897\u7c92\u4e2d\u542b\u6709 32 \u4e2a % \u591a\u7cd6\u3002.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p><strong>\u8bf7\u6ce8\u610f<\/strong>:<br>Dosierungsempfehlungen basieren ausschlie\u00dflich auf dem unter dem o.g. Link &#8222;Bezugsquelle&#8220; aufgef\u00fchrten Produkt, da, Stand 04.2026, nur dieses \u00fcber die nachgewiesenen 32% Polysaccahride und 58% \u03b2-<mark>Glukane<\/mark> verf\u00fcgt, die auch durch unabh\u00e4ngige Analyse-Daten (siehe die Links auf der Produktseite weiter unten) best\u00e4tigt sind.<\/p>\n<\/blockquote>\n\n\n\n<p>\u7814\u7a76\u8868\u660e\uff0c\u6000\u5c14\u83c7\u7684\u6d3b\u6027\u6210\u5206\u5177\u6709\u5e7f\u6cdb\u7684\u7eaf\u8c03\u8282\u548c\u7a0b\u5e8f\u7279\u6027\u3002\u5b83\u4eec\u80fd\u591f\u5c06\u5b9a\u5411\u9519\u8bef\u7684\u57fa\u56e0\u6062\u590d\u5230\u5176\u539f\u6709\u7684\u529f\u80fd\u8303\u56f4\uff0c\u751a\u81f3\u5c06\u5176\u91cd\u65b0\u7f16\u7a0b\u4ee5\u5b9e\u73b0\u6b63\u5e38\u529f\u80fd\u3002.<\/p>\n\n\n\n<p>\u57fa\u56e0\u53ef\u4ee5\u5f00\u542f\u6216\u5173\u95ed\uff0c\u4e5f\u53ef\u4ee5\u4e0a\u8c03\u6216\u4e0b\u8c03\u3002\u6240\u6709\u4e0d\u5728\u6b63\u5e38\u8303\u56f4\u5185\u7684\u60c5\u51b5\u90fd\u4f1a\u5bfc\u81f4\u5bf9\u4fe1\u53f7\u505a\u51fa\u76f8\u5e94\u7684\u8fc7\u5ea6\u53cd\u5e94\u6216\u6291\u5236\u53cd\u5e94\u3002Huaier \u7684\u6d3b\u6027\u6210\u5206\u80fd\u591f\u6709\u9009\u62e9\u6027\u5730\u6062\u590d\u5404\u81ea\u6b63\u786e\u7684\u8c03\u63a7\u884c\u4e3a\u3002.<\/p>\n\n\n\n<p>\u8fd9\u4e0e ARLA \u5728\u673a\u7406\u4e0a\u6709\u76f8\u4f3c\u4e4b\u5904\uff0c\u56e0\u6b64\u5728 ARLA \u7684\u53d1\u75c5\u673a\u5236\u4e2d\uff0cHuaier \u53ef\u4ee5\u5728\u56db\u4e2a\u5173\u952e\u7684\u5206\u5b50\u5e72\u9884\u70b9\u4e0a\u53d1\u6325\u4f5c\u7528\uff1a<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"NF-%CE%BAB-Pathway-Hemmung_Plasma-Membran-Signalisierung\"><\/span>NF-\u03baB \u901a\u8def\u6291\u5236\uff08\u8d28\u819c\u4fe1\u53f7\u4f20\u5bfc\uff09<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u5728\u611f\u67d3\u540e\u7684\u83b1\u59c6\u5173\u8282\u708e\u4e2d\uff0c\u5728\u6210\u529f\u5730\u7528\u6297\u751f\u7d20\u6cbb\u7597\u5305\u67d4\u6c0f\u83cc\u540e\uff0c\u6240\u8c13\u7684 <em>\u6301\u4e45\u6027\u80bd\u805a\u7cd6<\/em>, \u8fd9\u4e9b\u80bd\u805a\u7cd6\u4e0d\u65ad\u88ab\u514d\u75ab\u7cfb\u7edf\u8bc6\u522b\uff0c\u7279\u522b\u662f\u88ab\u514d\u75ab\u7cfb\u7edf\u8bc6\u522b\u3002\u8fd9\u4e9b\u80bd\u805a\u7cd6\u4f1a\u4e0d\u65ad\u88ab\u514d\u75ab\u7cfb\u7edf\u8bc6\u522b\uff0c\u5c24\u5176\u662f\u88ab\u4ee5\u4e0b\u7cfb\u7edf\u8bc6\u522b <em>Toll \u6837\u53d7\u4f53 2<\/em> (TLR2) \u5b9a\u4f4d\u4e8e\u5de8\u566c\u7ec6\u80de\u3001\u6811\u7a81\u72b6\u7ec6\u80de\u548c\u5176\u4ed6\u5148\u5929\u6027\u514d\u75ab\u7ec6\u80de\u7684\u8868\u9762\u3002.<\/p>\n\n\n\n<p>\u5f53 TLR2 \u8bc6\u522b\u5230\u6301\u4e45\u6027\u80bd\u805a\u7cd6\u65f6\uff0c\u4fe1\u53f7\u7ea7\u8054\u5c31\u4f1a\u542f\u52a8\uff0c\u4ece\u800c\u6fc0\u6d3b\u7ecf\u5178\u7684 \"TLR2 \"\u53cd\u5e94\u3002 <em>NF-\u03baB \u4fe1\u53f7\u901a\u8def<\/em> \u5bfc\u81f4\u3002\u8fd9\u662f\u901a\u8fc7\u62db\u52df\u9002\u914d\u86cb\u767d\uff08\u5982 <em>TIRAP<\/em> \u548c <em>MyD88<\/em> \u6fc0\u6d3b\u7684 TLR2 \u53d7\u4f53\u3002.<br>\u7136\u540e\uff0c\u8fd9\u4e9b\u9002\u914d\u86cb\u767d\u4f1a\u62db\u52df\u4e00\u4e2a\u6fc0\u9176\u590d\u5408\u4f53\uff0c\u5176\u4e2d\u5305\u62ec <em>IKK \u590d\u5408\u7269<\/em> (\u03baB\u6fc0\u9176\u6291\u5236\u5242\uff09\uff0c\u5b83\u662f\u4e00\u79cd\u6291\u5236\u86cb\u767d <em>I\u03baB\u03b1<\/em> \u78f7\u9178\u5316\uff0c\u4ece\u800c\u6807\u8bb0\u4e3a\u86cb\u767d\u9176\u4f53\u964d\u89e3\u3002\u968f\u7740 I\u03baB\u03b1 \u7684\u964d\u89e3\uff0c\u86cb\u767d\u9176\u4f53\u4e2d\u7684 <em>\u8f6c\u5f55\u56e0\u5b50\u4e8c\u805a\u4f53 p50\/p65<\/em> \u4ece NF-\u03baB \u4e2d\u91ca\u653e\u51fa\u6765\uff0c\u5e76\u80fd\u8f6c\u79fb\u5230\u7ec6\u80de\u6838\u4e2d\u3002.<\/p>\n\n\n\n<p>\u4e00\u65e6\u7ec6\u80de\u6838\u4e2d\u51fa\u73b0 NF-\u03baB\uff0c\u5b83\u5c31\u4f1a\u4e0e\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\u542f\u52a8\u5b50\u533a\u57df\u4e2d\u7684\u03baB DNA \u7ed3\u5408\u4f4d\u70b9\u7ed3\u5408\uff0c\u5e76\u542f\u52a8\u5176\u5927\u91cf\u8f6c\u5f55\u3002\u8fd9\u5bfc\u81f4\u6301\u7eed\u4e0d\u65ad\u5730\u4ea7\u751f <em>TNF-\u03b1\u3001IL-6\u3001IL-1\u03b2\u3001IL-8<\/em> \u548c\u5176\u4ed6\u8d8b\u5316\u56e0\u5b50\uff0c\u5982 <em>MCP-1<\/em> \u548c <em>KC<\/em>.<br>\u5728 ARLA \u60a3\u8005\u4e2d\uff0c\u8fd9\u4e00\u8fc7\u7a0b\u4e0d\u4f1a\u81ea\u884c\u7ec8\u6b62\u3002\u53ea\u8981\u80bd\u805a\u7cd6\u4ecd\u7136\u5b58\u5728\uff0c\u8fd9\u4e00\u8fc7\u7a0b\u5c31\u4f1a\u6301\u7eed\u6570\u5468\u3001\u6570\u6708\u751a\u81f3\u6570\u5e74\u3002\u8fd9\u5c31\u662f\u6838\u5fc3\u95ee\u9898\u6240\u5728\uff1a\u6ca1\u6709\u65b0\u7684\u611f\u67d3\u9700\u8981\u6297\u51fb\uff0c\u4f46\u514d\u75ab\u7cfb\u7edf\u4ecd\u7136\u505c\u7559\u5728\u708e\u75c7\u6a21\u5f0f\u4e2d\u3002.<\/p>\n\n\n\n<p><strong>\u6000\u5c14\u5982\u4f55\u4e2d\u65ad\u8fd9\u4e00\u8fc7\u7a0b\uff1a<\/strong><\/p>\n\n\n\n<p>\u6000\u5c14\u5bcc\u542b <em>\u03b2-\u8461\u805a\u7cd6<\/em> \u53ca\u5176\u4ed6 <em>\u591a\u7cd6<\/em>, \u4e0e TLR2 \u4ee5\u5916\u7684\u53d7\u4f53\u7ed3\u5408\uff0c\u5373\u6240\u8c13\u7684 <em>Dectin-1 \u53d7\u4f53<\/em> (Dectin-1 \u662f\u4e00\u79cd <em>C \u578b\u51dd\u96c6\u7d20\u53d7\u4f53<\/em>, \u4e3b\u8981\u5728\u5de8\u566c\u7ec6\u80de\u548c\u6811\u7a81\u72b6\u7ec6\u80de\u4e0a\u8868\u8fbe\uff09\u3002\u5f53\u6dee\u5c14\u7684\u03b2-\u8461\u805a\u7cd6\u4e0e Dectin-1 \u7ed3\u5408\u65f6\uff0c\u5b83\u4eec\u4e5f\u4f1a\u6fc0\u6d3b NF-\u03baB\uff0c\u4f46\u901a\u8fc7\u7684\u662f\u53e6\u4e00\u79cd\u4fc3\u708e\u6027\u8f83\u4f4e\u7684\u4fe1\u53f7\u9014\u5f84\u3002.<br>\u800c\u4e0d\u662f\u7ecf\u5178\u7684 <em>TIRAP\/MyD88\u8def\u7ebf<\/em> \u4e0e TLR2 \u4fe1\u53f7\u4e00\u6837\uff0c\u4fe1\u53f7\u4e5f\u662f\u901a\u8fc7\u4ee5\u4e0b\u65b9\u5f0f\u4f20\u9012\u7684 <em>Syk \u6fc0\u9176<\/em> \u548c <em>\u5361\u7247 9<\/em>, \u8fd9\u5bfc\u81f4\u4e86\u4e00\u79cd \u201e\u53d7\u8c03\u8282\u7684 \u201cNF-\u03baB \u4fe1\u53f7\u3002.<\/p>\n\n\n\n<p>\u6b64\u5916\uff0c\u6000\u5c14\u8fd8\u901a\u8fc7\u4ee5\u4e0b\u9014\u5f84\u5f00\u5c55\u5de5\u4f5c <em>miRNA \u4ecb\u5bfc\u7684<\/em> \u5bfc\u81f4 NF-\u03baB \u6210\u5206\u672c\u8eab\u51cf\u5c11\u7684\u673a\u5236\u3002\u6000\u5c14\u4e0a\u8c03\u7684\u7279\u5b9a microRNA\uff08\u5982 <em>miRNA-223\u3001miRNA-146a<\/em> \u7b49\uff09\u80fd\u76f4\u63a5\u964d\u89e3 IKK \u4e9a\u57fa\u548c RelA\uff08NF-\u03baB \u7684 p65 \u4e9a\u57fa\uff09\u7684 mRNA\u3002\u8fd9\u610f\u5473\u7740\uff0c\u5373\u4f7f\u80bd\u805a\u7cd6\u4ecd\u7136\u5b58\u5728\u5e76\u523a\u6fc0 TLR2\uff0c\u7ec6\u80de\u4e2d\u53ef\u88ab\u6fc0\u6d3b\u7684 NF-\u03baB \u590d\u5408\u7269\u603b\u91cf\u4e5f\u4f1a\u51cf\u5c11\u3002.<\/p>\n\n\n\n<p>\u6000\u5c14\u8fd9\u79cd\u53cc\u91cd\u5e72\u9884\u7684\u5b9e\u9645\u6548\u679c\u662f\uff0c\u80bd\u805a\u7cd6\u5bf9 NF-\u03baB \u7684\u6301\u7eed\u6fc0\u6d3b\u5927\u5927\u51cf\u5c11\u3002TNF-\u03b1 \u7684\u4ea7\u751f\u51cf\u5c11\uff0cIL-6 \u7684\u4ea7\u751f\u51cf\u5c11\uff0cIL-1\u03b2 \u7684\u4ea7\u751f\u51cf\u5c11\u3002\u5728\u4e34\u5e8a\u4e0a\uff0c\u8fd9\u4f1a\u5bfc\u81f4 C \u53cd\u5e94\u86cb\u767d\uff08CRP\uff09\u8fc5\u901f\u4e0b\u964d\uff0c\u800c C \u53cd\u5e94\u86cb\u767d\u662f\u4e00\u79cd\u7531 NF-\u03baB \u5f15\u53d1\u7684\u6025\u6027\u671f\u86cb\u767d\u3002.<br>\u7531\u4e8e\u4f5c\u4e3a\u8d8b\u5316\u56e0\u5b50\u7684 TNF-\u03b1 \u548c IL-6 \u51cf\u5c11\u4e86\uff0c\u767d\u7ec6\u80de\u8fdb\u5165\u5173\u8282\u7684\u6570\u91cf\u4e5f\u51cf\u5c11\u4e86\uff0c\u56e0\u6b64\u5173\u8282\u79ef\u6db2\u5438\u6536\u5f97\u66f4\u5feb\u3002\u60a3\u8005\u62a5\u544a\u8bf4\uff0c\u5728\u5f00\u59cb\u4f7f\u7528 \"\u6167\u5c14 \"\u540e\u7684 1-2 \u5468\u5185\uff0c\u80bf\u80c0\u548c\u75bc\u75db\u8fc5\u901f\u51cf\u8f7b\u3002\u8fd9\u4e0e NF-\u03baB \u6291\u5236\u4f5c\u7528\u662f\u4e00\u81f4\u7684\u3002.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"JAKSTAT-Pathway-Modulation_Endosomal-Signalisierung_IL-6-Feedback\"><\/span>JAK\/STAT \u901a\u8def\u8c03\u8282\uff08\u5185\u4f53\u4fe1\u53f7 + IL-6 \u53cd\u9988\uff09<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>ARLA \u662f\u6307\u8fc7\u5ea6\u751f\u4ea7 <em>I \u578b\u5e72\u6270\u7d20<\/em> (\u5e72\u6270\u7d20-\u03b1\u548c\u5e72\u6270\u7d20-\u03b2\uff09\uff0c\u88ab\u79f0\u4e3a\u201e<em>IFN \u653e\u5927\u73af<\/em>\u201c\u6807\u8bb0\u3002\u8fd9\u5e76\u4e0d\u662f\u6211\u4eec\u521a\u624d\u8ba8\u8bba\u7684 NF-\u03baB \u7684\u5178\u578b TLR2 \u4fe1\u53f7\u3002\u76f8\u53cd\uff0c\u8fd9\u662f\u901a\u8fc7\u53e6\u4e00\u79cd\u9014\u5f84\u53d1\u751f\u7684\uff1a\u6301\u7eed\u5b58\u5728\u7684\u5305\u67d4\u6c0f\u83cc\u662f\u901a\u8fc7 <em>\u5de8\u566c\u7ec6\u80de<\/em> \u548c <em>\u6811\u7a81\u72b6\u7ec6\u80de<\/em> \u88ab\u541e\u566c\u3002\u5f53\u5b83\u4eec\u88ab\u5e26\u5165\u541e\u566c\u4f53\u65f6\uff0c\u4f1a\u88ab\u5185\u4f53 Toll \u6837\u53d7\u4f53\u8bc6\u522b\uff0c\u7279\u522b\u662f <em>TLR7\u3001TLR8<\/em> \u548c <em>TLR9<\/em>. .\u8fd9\u4e9b\u53d7\u4f53\u4f4d\u4e8e <em>\u5185\u6ccc\u4f53\/\u541e\u566c\u6ce1<\/em> \u5e76\u8bc6\u522b Borrelia RNA \u548c DNA\u3002.<\/p>\n\n\n\n<p>\u5f53\u7ec6\u83cc\u6838\u9178\u523a\u6fc0 TLR7\/8\/9 \u65f6\uff0c\u5b83\u4eec\u4f1a\u62db\u52df\u9002\u914d\u86cb\u767d <em>MyD88<\/em> \u548c\/\u6216 <em>TRIF<\/em> \u5e76\u5bfc\u81f4\u5e72\u6270\u7d20\u8c03\u8282\u56e0\u5b50\u7684\u6fc0\u6d3b\uff0c\u7279\u522b\u662f <em>IRF3<\/em> \u548c <em>IRF7<\/em>. .\u7136\u540e\uff0c\u8fd9\u4e9b IRF \u8f6c\u5f55\u56e0\u5b50\u8fdb\u5165\u7ec6\u80de\u6838\uff0c\u542f\u52a8 I \u578b\u5e72\u6270\u7d20\u57fa\u56e0\u7684\u8f6c\u5f55\uff1a\u6700\u521d\u662f <em>\u5e72\u6270\u7d20-\u03b2<\/em> \u968f\u540e\u662f <em>\u5e72\u6270\u7d20-\u03b1<\/em>.<\/p>\n\n\n\n<p>\u4e00\u65e6 IFN-\u03b1 \u548c IFN-\u03b2 \u88ab\u91ca\u653e\u5230\u6ed1\u6db2\u548c\u8840\u6db2\u4e2d\uff0c\u5b83\u4eec\u5c31\u4f1a\u4e0e\u5e72\u6270\u7d20-\u03b1\/\u03b2 \u53d7\u4f53 (IFNAR) \u7ed3\u5408\u3002 <em>T \u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de<\/em> \u548c <em>\u6ed1\u819c\u6210\u7ea4\u7ef4\u7ec6\u80de<\/em>.<br>IFNAR \u4e0e\u53d7\u4f53\u7ed3\u5408\u540e\u4f1a\u62db\u52df\u4e24\u79cd\u6fc0\u9176\uff1a <em>JAK1<\/em> \u548c <em>TYK2<\/em>. .\u7136\u540e\uff0c\u8fd9\u4e9b\u6fc0\u9176\u4f1a\u4f7f STAT \u86cb\u767d\u78f7\u9178\u5316 <em>STAT1<\/em> \u548c <em>STAT2<\/em> (<strong>\u4e0d<\/strong> <em>STAT3<\/em> \u5728\u8fd9\u4e00\u7279\u5b9a\u9014\u5f84\u4e2d\uff09\u3002\u78f7\u9178\u5316\u7684 STAT1\/STAT2 \u4e0e <em>IRF9<\/em> \u7684\u8f6c\u5f55\u56e0\u5b50\u590d\u5408\u4f53 <em>ISGF3<\/em> \u5e76\u8fdb\u5165\u7ec6\u80de\u6838\u3002.<\/p>\n\n\n\n<p>\u5728\u7ec6\u80de\u6838\u4e2d\uff0cISGF3 \u4e0e\u4ee5\u4e0b\u7269\u8d28\u7ed3\u5408 <em>\u5e72\u6270\u7d20\u523a\u6fc0\u53cd\u5e94\u5143\u4ef6<\/em> \uff08ISREs\uff09\u7684\u542f\u52a8\u5b50\u533a\u57df\u3002 <em>\u5e72\u6270\u7d20\u523a\u6fc0\u57fa\u56e0<\/em> (ISGs)\u3002\u8fd9\u4e9b ISG \u5305\u62ec\u4ee5\u4e0b\u57fa\u56e0 <em>\u7f8e\u6d32\u56fd\u5bb6\u7ec4\u7ec7<\/em> (2\u2032\uff0c5\u2032-\u9187\u817a\u82f7\u9178\u5408\u6210\u9176\uff09\u3001, <em>MxA<\/em> (\u808c\u7624\u75c5\u6bd2\u6297\u6027\u86cb\u767d A\uff09\u3001, <em>PBR<\/em> (\u86cb\u767d\u6fc0\u9176 R\uff09\u548c\u8bb8\u591a\u5176\u4ed6\u57fa\u56e0\u3002\u8fd9\u4e9b\u57fa\u56e0\u88ab\u5927\u91cf\u4e0a\u8c03\uff0c\u5728\u7ec6\u80de\u4e2d\u5f62\u6210\u4e00\u79cd \u201e\u6297\u75c5\u6bd2\u72b6\u6001\u201c\u3002\u8fd9\u5728\u771f\u6b63\u7684\u75c5\u6bd2\u611f\u67d3\u4e2d\u662f\u6b63\u5e38\u7684\u548c\u9002\u5e94\u6027\u7684\uff0c\u4f46\u5728 ARLA \u4e2d\u5374\u662f\u4e0d\u9002\u5e94\u7684\uff0c\u56e0\u4e3a\u6ca1\u6709\u6d3b\u8dc3\u7684\u75c5\u6bd2\u611f\u67d3\u3002\u8fd9\u662f\u4e00\u79cd \u201e\u5047\u8b66\u62a5\u201c\u3002.<\/p>\n\n\n\n<p>\u53cd\u9988\u673a\u5236\u4f7f\u95ee\u9898\u53d8\u5f97\u66f4\u52a0\u4e25\u91cd\uff1a\u4ea7\u751f\u5e72\u6270\u7d20\u7684\u7ec6\u80de\u4f1a\u4ea7\u751f\u66f4\u591a\u5e72\u6270\u7d20\uff0c\u4ece\u800c\u5728\u5176\u4ed6\u7ec6\u80de\u4e2d\u5f15\u53d1\u66f4\u5f3a\u7684 IFNAR \u4fe1\u53f7\uff0c\u8fdb\u800c\u5bfc\u81f4\u66f4\u591a\u7684 ISG \u8f6c\u5f55\uff0c\u8fd9\u53cd\u8fc7\u6765\u53c8\u589e\u52a0\u4e86\u4ea7\u751f\u66f4\u591a IFN \u7684\u53ef\u80fd\u6027\u3002\u8fd9\u5c31\u662f\u201e<em>IFN \u653e\u5927\u73af<\/em>\u201e\uff0c\u8fd9\u662f\u611f\u67d3\u540e ARLA \u7684\u7279\u5f81\u3002\u8fd9\u4e00\u5faa\u73af\u662f\u81ea\u6211\u5ef6\u7eed\u7684\uff1a\u5373\u4f7f\u6240\u6709\u6d3b\u7684\u5305\u67d4\u6c0f\u83cc\u90fd\u5df2\u88ab\u6740\u6b7b\uff0c\u8fd9\u4e00\u9014\u5f84\u4ecd\u5728\u7ee7\u7eed\uff0c\u56e0\u4e3a\u6b7b\u4ea1\u7684\u7ec6\u83cc\u53ca\u5176\u6838\u9178\u4ecd\u5728\u88ab\u541e\u566c\u3002.<\/p>\n\n\n\n<p>\u540c\u65f6\uff0c\u8fd9\u79cd I \u578b IFN \u72b6\u6001\u4e5f\u4f1a\u5bfc\u81f4 T \u7ec6\u80de\u7684\u6d3b\u5316\u548c\u6269\u589e\uff0c\u7279\u522b\u662f <em>Th1 \u7ec6\u80de<\/em> \u540e\u6765\u8fd8 <em>Th17 \u7ec6\u80de<\/em>. .Th17 \u7ec6\u80de\u662f\u901a\u8fc7\u4e0d\u540c\u7684\u673a\u5236\u6fc0\u6d3b\u7684\uff1a\u5b83\u4eec\u9700\u8981 <em>IL-6<\/em> \u4e0e <em>TGF-\u03b2<\/em>. .\u800c IL-6 \u4e5f\u662f\u7531 NF-\u03baB \u548c\u5e72\u6270\u7d20\u523a\u6fc0\u57fa\u56e0\u4ea7\u751f\u7684\u3002\u56e0\u6b64\uff0cIL-6 \u7684\u4ea7\u751f\u6709\u591a\u79cd\u9014\u5f84\u3002.<\/p>\n\n\n\n<p>\u4e00\u65e6 IL-6 \u5927\u91cf\u5b58\u5728\uff0c\u6709\u8da3\u7684\u4e8b\u60c5\u5c31\u4f1a\u53d1\u751f\uff1aIL-6 \u4e0e\u5176\u53d7\u4f53\uff08<em>IL-6R<\/em>)\u4e0e\u4e00\u79cd\u53eb\u505a <em>gp130<\/em> \u5728 T \u7ec6\u80de\u3001\u6ed1\u819c\u6210\u7ea4\u7ef4\u7ec6\u80de\u548c\u5176\u4ed6\u7ec6\u80de\u8868\u9762\u3002\u8fd9\u79cd\u7ed3\u5408\u4f1a\u5c06 JAK1 \u548c JAK2 \u52df\u96c6\u5230\u53d7\u4f53\u4e0a\u3002\u7136\u540e\uff0cJAK1 \u548c JAK2 \u4f7f STAT \u86cb\u767d STAT3 \u78f7\u9178\u5316\u3002\u78f7\u9178\u5316\u540e\uff0cSTAT3 \u88ab\u6fc0\u6d3b\u5e76\u8fdb\u5165\u7ec6\u80de\u6838\uff0c\u4e0e DNA \u7ed3\u5408\u4f4d\u70b9\u7ed3\u5408\uff0c\u542f\u52a8 IL-17 \u548c\u8f6c\u5f55\u56e0\u5b50 ROR\u03b3t \u7684\u8f6c\u5f55\u3002.<\/p>\n\n\n\n<p>\u8fd9\u5bfc\u81f4 Th17 \u7ec6\u80de\u5927\u91cf\u7e41\u6b96\uff0c\u8fdb\u800c\u4ea7\u751f\u66f4\u591a\u7684 IL-17\u3002IL-17 \u5177\u6709\u5f88\u5f3a\u7684\u4fc3\u708e\u4f5c\u7528\uff0c\u4f1a\u4f5c\u7528\u4e8e\u6ed1\u819c\u6210\u7ea4\u7ef4\u7ec6\u80de\uff08\u5373\u6240\u8c13\u7684 FLS - \u6210\u7ea4\u7ef4\u7ec6\u80de\u6837\u6ed1\u819c\u7ec6\u80de\uff09\uff0c\u4ece\u800c\u4ea7\u751f\u66f4\u591a\u7684 IL-6\u3002\u8fd9\u5c31\u5f62\u6210\u4e86\u7b2c\u4e8c\u4e2a\u53cd\u9988\u7cfb\u7edf\uff1aIL-6 \u2192 Th17 \u6269\u5927 \u2192 IL-17 \u4ea7\u751f \u2192 FLS \u4ea7\u751f\u66f4\u591a\u7684 IL-6 \u2192 \u66f4\u591a\u7684 Th17 \u2192 \u66f4\u591a\u7684 IL-17\u3002 \u4e0e IFN \u653e\u5927\u73af\u4e00\u6837\uff0c\u8fd9\u79cd\u60c5\u51b5\u4f1a\u81ea\u6211\u5ef6\u7eed\uff0c\u5e76\u4f7f ARLA \u5177\u6709\u6162\u6027\u3001\u96be\u4ee5\u63a7\u5236\u7684\u7279\u70b9\u3002.<\/p>\n\n\n\n<p><strong>\u6000\u5c14\u5982\u4f55\u4e2d\u65ad\u8fd9\u4e00\u8fc7\u7a0b\uff1a<\/strong><\/p>\n\n\n\n<p>\u4e0e\u76f4\u63a5\u963b\u65ad JAK1 \u6216 JAK2 \u76f8\u6bd4\uff0cHuaier \u80fd\u5728\u66f4\u6839\u672c\u7684\u5c42\u9762\u4e0a\u5e72\u6270 JAK\/STAT \u901a\u8def\uff08\u56e0\u4e3a\u5b83 <em>JAK \u6291\u5236\u5242<\/em> \u559c\u6b22 <em>\u4e4c\u8fbe\u66ff\u5c3c<\/em> \u505a\uff09\u3002. <strong>\u76f8\u53cd\uff0cHuaier \u901a\u8fc7 miRNA \u4ecb\u5bfc\u7684\u8f6c\u5f55\u8c03\u63a7\u53d1\u6325\u4f5c\u7528<\/strong>. .\u6000\u5c14\u591a\u7cd6\u4e0a\u8c03\u7684\u7279\u5b9a\u5faeRNA\u4f1a\u7834\u574f\u6216\u964d\u89e3JAK\u86cb\u767d\u672c\u8eab\u7684mRNA\u3002.<\/p>\n\n\n\n<p>\u8fd9\u662f\u901a\u8fc7\u4e00\u79cd\u4f18\u96c5\u7684\u8c03\u63a7\u673a\u5236\u5b9e\u73b0\u7684\uff1a\u5f53\u6000\u5c14\u591a\u7cd6\u4e0e Dectin-1 \u7ed3\u5408\u5e76\u901a\u8fc7\u4fe1\u53f7\u523a\u6fc0\u7ec6\u80de\u65f6\uff0c\u4e0d\u4ec5\u4f1a\u6fc0\u6d3b\u5355\u4e00\u7684\u4fe1\u53f7\u901a\u8def\uff0c\u800c\u4e14\u8fd8\u4f1a\u52a0\u901f miRNA \u5904\u7406\u9176\u7684\u4f5c\u7528\u3002\u8fd9\u4e9b\u9176\u5bfc\u81f4\u591a\u79cd\u89c4\u8303\u548c\u975e\u89c4\u8303 miRNA \u7684\u751f\u7269\u751f\u6210\u3002\u5176\u4e2d\u4e00\u4e9b miRNA\uff0c\u5982 <strong>miR-223\u3001miR-146a<\/strong> \u548c <strong>miR-34a<\/strong>, \u5728 3\u2032-\u975e\u7ffb\u8bd1\u533a\uff083\u2032-untranslated region\uff09\u6709\u7ed3\u5408\u4f4d\u70b9\u3002<strong>3\u2032-UTR<\/strong>)\u4ece <em>JAK1\u3001JAK2<\/em> \u548c <em>STAT3 mRNA<\/em>.<br>\u5f53\u8fd9\u4e9b miRNA \u4e0e\u8fd9\u4e9b\u5e8f\u5217\u6742\u4ea4\u65f6\uff0c\u5b83\u4eec\u4f1a\u6807\u8bb0 mRNA\uff0c\u4ee5\u4fbf\u901a\u8fc7 <strong>RISC \u590d\u5408\u7269<\/strong> (RNA \u8bf1\u5bfc\u7684\u6c89\u9ed8\u590d\u5408\u4f53\uff09\u3002\u5176\u7ed3\u679c\u662f\uff0cmRNA \u88ab\u964d\u89e3\uff0c\u8fd9\u4e9b\u86cb\u767d\u8d28\u4e0d\u518d\u80fd\u6709\u6548\u5730\u4ea7\u751f\u3002.<\/p>\n\n\n\n<p>\u5728\u63a5\u89e6\u6000\u5c14\u540e\u7684\u51e0\u5929\u5230\u4e00\u5468\u5185\uff0c\u7ec6\u80de\u53ea\u662f <strong>\u51cf\u5c11 JAK1-\u3001JAK2-<\/strong> \u548c <strong>STAT3 \u86cb\u767d<\/strong>. .\u8fd9\u6bd4\u7b80\u5355\u5730\u963b\u65ad\u6fc0\u9176\u6d3b\u6027\u66f4\u4e3a\u91cd\u8981\u3002\u8fd9\u610f\u5473\u7740\uff0c\u5373\u4f7f\u53d7\u4f53\u88ab\u6fc0\u6d3b\u5e76\u8bd5\u56fe\u4f7f JAK \u78f7\u9178\u5316\uff0c\u8981\u78f7\u9178\u5316\u7684 JAK \u5206\u5b50\u6570\u91cf\u4e5f\u4f1a\u51cf\u5c11\u3002\u8fd9\u610f\u5473\u7740 <strong>\u5bf9 JAK \u4f9d\u8d56\u6027\u7ec6\u80de\u56e0\u5b50\u4fe1\u53f7\u7684\u53cd\u5e94<\/strong> \u56e0\u6b64 <strong>\u5927\u51cf<\/strong>.<\/p>\n\n\n\n<p>JAK \u8868\u8fbe\u7684\u51cf\u5c11\u4e2d\u65ad\u4e86 I \u578b IFN \u7684\u653e\u5927\u5faa\u73af\u3002\u5373\u4f7f TLR7\/8\/9 \u7ee7\u7eed\u5c1d\u8bd5\u4ea7\u751f\u5e72\u6270\u7d20\uff0c\u4ea7\u751f IFN-\u03b1\/\u03b2 \u7684\u7ec6\u80de\u4e2d JAK1\/TYK2 \u7684\u542b\u91cf\u4e5f\u4f1a\u51cf\u5c11\uff0c\u56e0\u6b64 STAT1\/STAT2 \u78f7\u9178\u5316\u7684\u6548\u7387\u4e5f\u4f1a\u964d\u4f4e\u3002\u8fd9\u5c31\u5bfc\u81f4 ISGF3 \u6fc0\u6d3b\u51cf\u5c11\uff0cISG \u8f6c\u5f55\u51cf\u5c11\uff0c\u56e0\u6b64 <strong>\u51cf\u5c11 \u201e\u6297\u75c5\u6bd2\u72b6\u6001\u201c<\/strong>.<\/p>\n\n\n\n<p>\u540c\u65f6\uff0cJAK1 \u548c JAK2 \u7684\u51cf\u5c11\u4e5f\u4e2d\u65ad\u4e86 IL-6 \u7684\u53cd\u9988\u56de\u8def\u3002\u5373\u4f7f IL-6 \u5b58\u5728\u5e76\u4e0e T \u7ec6\u80de\u4e0a\u7684 IL-6R \u7ed3\u5408\uff0c\u53ef\u78f7\u9178\u5316\u7684 JAK1 \u548c JAK2 \u4e5f\u4f1a\u51cf\u5c11\uff0c\u56e0\u6b64 STAT3 \u7684\u78f7\u9178\u5316\u7a0b\u5ea6\u4e5f\u4f1a\u964d\u4f4e\u3002\u7531\u4e8e STAT3 \u7684\u6d3b\u6027\u964d\u4f4e\uff0cROR\u03b3t \u548c IL-17 \u7684\u4ea7\u751f\u5c31\u4f1a\u51cf\u5c11\uff0c\u56e0\u6b64 Th17 \u7ec6\u80de\u5c31\u4e0d\u4f1a\u50cf\u4ee5\u524d\u90a3\u6837\u79ef\u6781\u6269\u5f20\u3002\u8fd9\u610f\u5473\u7740 IL-17 \u7684\u4ea7\u751f\u51cf\u5c11\uff0c\u5bf9 FLS \u4ea7\u751f IL-6 \u7684\u523a\u6fc0\u51cf\u5c11\uff0c\u5faa\u73af\u5c31\u88ab\u6253\u7834\u4e86\u3002.<\/p>\n\n\n\n<p>\u5728\u5b9e\u9a8c\u5ba4\u4e2d\uff0c\u6211\u4eec\u5c06\u5176\u89c6\u4e3a <strong>IFN-\u03b3 \u6c34\u5e73\u4e0b\u964d<\/strong> (Th1\u6d3b\u52a8\u7684\u6807\u8bb0\uff0cI\u578bIFN\u4e5f\u4f1a\u4e0a\u8c03\uff09\u3001, <strong>IL-6 \u6c34\u5e73\u4e0b\u964d <\/strong>(IL-6 \u53cd\u9988\u7cfb\u7edf\u7684\u6807\u8bb0\uff09\u548c <strong>IL-17 \u6c34\u5e73\u4e0b\u964d<\/strong> (Th17\u7684\u6807\u5fd7\u7269\uff09\u3002\u4e0e NF-\u03baB \u6291\u5236\uff08\u51e0\u5929\u5185\u53d1\u751f\uff09\u76f8\u6bd4\uff0cmiRNA \u7684\u4f5c\u7528\u53d1\u751f\u5f97\u66f4\u6162--\u5927\u7ea6\u9700\u8981 2-4 \u5468\u7684\u65f6\u95f4\u624d\u80fd\u5b8c\u5168\u663e\u73b0\uff0c\u4f46\u4e00\u65e6\u663e\u73b0\uff0c\u5c31\u4f1a\u66f4\u52a0\u6301\u4e45\u3002.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Vergleich_JAK1i_wie_Upadacitinib_vs_Huaier\"><\/span><br><strong>\u6bd4\u8f83\uff1aJAK1i\uff08\u5982 upadacitinib\uff09\u4e0e\u6000\u5c14\uff1a<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>A <strong>JAK1 \u6291\u5236\u5242<\/strong> \u559c\u6b22 <em>\u4e4c\u8fbe\u66ff\u5c3c<\/em> (\u5c3d\u7ba1\u4e24\u8005\u6700\u7ec8\u90fd\u4f1a\u8c03\u8282 JAK\/STAT \u4fe1\u53f7\u901a\u8def\uff0c\u4f46\u5965\u5e15\u4ed6\u66ff\u5c3c\uff08\u5546\u54c1\u540d Rinvoq\uff09\u7684\u4f5c\u7528\u673a\u5236\u4e0e\u6000\u5c14\u5b8c\u5168\u4e0d\u540c\u3002\u4e4c\u5e15\u4ed6\u66ff\u5c3c\u662f\u4e00\u79cd\u5c0f\u5206\u5b50\uff0c\u53ef\u4ee5\u76f4\u63a5 <em>ATP \u7ed3\u5408\u888b<\/em> \u7684 <em>JAK1 \u6fc0\u9176<\/em> \u5e76\u5bf9\u5176\u8fdb\u884c\u7269\u7406\u963b\u65ad\u3002\u8fd9\u662f\u4e00\u79cd \u201e\u673a\u68b0\u6291\u5236\u5242\u201c\u3002.<br>\u5f53JAK1\u88ab\u963b\u65ad\u65f6\uff0c\u65e0\u8bba\u53d7\u4f53\u5982\u4f55\u52aa\u529b\u6fc0\u6d3bJAK\uff0c\u5b83\u90fd\u65e0\u6cd5\u518d\u4f7fSTAT\u86cb\u767d\u4e0a\u7684\u6c28\u57fa\u9178\u916a\u6c28\u9178\u78f7\u9178\u5316\u3002\u8fbe\u5e15\u66ff\u5c3c\u7684\u4f5c\u7528\u975e\u5e38\u8fc5\u901f\uff1a\u4e00\u65e6\u8fbe\u5e15\u66ff\u5c3c\u88ab\u8840\u6db2\u5438\u6536\u5e76\u5230\u8fbe\u7ec6\u80de\uff0cJAK1\u5c31\u4f1a\u88ab\u6291\u5236\u3002\u8fd9\u5c31\u662f\u4e3a\u4ec0\u4e48JAK\u6291\u5236\u5242\u8d77\u6548\u8fc5\u901f\uff0c\u901a\u5e382-4\u5468\u5c31\u80fd\u53d6\u5f97\u660e\u663e\u7684\u4e34\u5e8a\u6539\u5584\u3002.<\/p>\n\n\n\n<p>\u7136\u800c\uff0c\u8fd9\u79cd\u76f4\u63a5\u963b\u65ad\u4e5f\u6709\u7f3a\u70b9\u3002JAK1 \u6291\u5236\u5242\u4e0d\u4ec5\u4f1a\u6291\u5236 JAK1\uff0c\u8fd8\u4f1a\u5728\u4e0d\u540c\u7a0b\u5ea6\u4e0a\u6291\u5236\u5176\u4ed6 JAK \u6fc0\u9176\uff0c\u8fd9\u53d6\u51b3\u4e8e\u5b83\u4eec\u7684\u9009\u62e9\u6027\u3002\u5373\u4f7f\u662f \u201eJAK1 \u9009\u62e9\u6027 \u201c\u6291\u5236\u5242\u4e5f\u4f1a\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u5bf9 JAK2 \u548c TYK2 \u4ea7\u751f\u5fae\u5f31\u7684\u6291\u5236\u4f5c\u7528\u3002\u8fd9\u5bfc\u81f4 <strong>\u526f\u4f5c\u7528<\/strong>, \u7279\u522b\u662f\u60a3\u4ee5\u4e0b\u75be\u75c5\u7684\u98ce\u9669\u589e\u52a0 <strong>\u5e26\u72b6\u75b1\u75b9<\/strong> (\u5e26\u72b6\u75b1\u75b9\uff09\uff0c\u56e0\u4e3a\u963b\u65ad JAK3 \u4f1a\u635f\u5bb3 T \u7ec6\u80de\u589e\u6b96\uff0c\u4ece\u800c\u5f71\u54cd\u5bf9\u6f5c\u4f0f\u75c5\u6bd2\u7684\u63a7\u5236\uff0c\u4f8b\u5982 <em>\u6c34\u75d8\u5e26\u72b6\u75b1\u75b9<\/em> \u51cf\u5f31\u3002\u603b\u4f53\u800c\u8a00\uff0c\u963b\u65ad JAK2 \u4f1a\u5bfc\u81f4 <strong>\u8840\u6813\u6813\u585e\u6fc0\u6d3b<\/strong> \u800c\u4e0d\u662f\u6291\u5236\uff08\u5c24\u5176\u662f\u5df4\u5229\u66ff\u5c3c\uff0c\u5b83\u5bf9 JAK2 \u7684\u963b\u65ad\u4f5c\u7528\u66f4\u5f3a\uff09\u3002.<\/p>\n\n\n\n<p><strong>\u6000\u5c14<\/strong> \u5728\u5b8c\u5168\u4e0d\u540c\u7684\u5c42\u9762\u4e0a\u53d1\u6325\u4f5c\u7528\u3002\u5b83\u5e76\u4e0d\u76f4\u63a5\u963b\u65ad JAK \u86cb\u767d\u3002\u800c\u662f <strong>\u51cf\u5c11<\/strong> \u5b83 <strong>JAK \u86cb\u767d\u7684\u6570\u91cf<\/strong>, \u7ec6\u80de\u6839\u672c\u4e0d\u4f1a\u4ea7\u751f\u3002\u8fd9\u662f\u901a\u8fc7 miRNA \u4ecb\u5bfc\u7684 JAK mRNA \u964d\u89e3\u5b9e\u73b0\u7684\u3002\u8fd9\u79cd\u673a\u5236\u7684\u4f18\u70b9\u662f\u66f4\u5fae\u5999\uff0c\u53ef\u80fd\u66f4\u7b26\u5408\u751f\u7406\u5b66\u539f\u7406\u3002\u7ec6\u80de\u53ea\u9700\u4e0b\u8c03\u5b83\u4eec\u4ea7\u751f JAK \u7684\u6570\u91cf\uff0c\u800c\u4e0d\u662f\u7528\u836f\u7269\u5f3a\u884c\u963b\u65ad\u86cb\u767d\u8d28\u3002\u7f3a\u70b9\u662f\u8fd9\u4e2a\u8fc7\u7a0b\u6bd4\u8f83\u7f13\u6162\u3002\u9700\u8981\u51e0\u5929\u5230\u4e00\u5468\u7684\u65f6\u95f4\uff0cmiRNA\u624d\u80fd\u5f97\u5230\u8db3\u591f\u6570\u91cf\u7684\u4e0a\u8c03\uff0c\u7136\u540e\u53c8\u9700\u8981\u51e0\u5929\u7684\u65f6\u95f4\uff0c\u624d\u80fd\u964d\u89e3\u8db3\u591f\u7684JAK mRNA\uff0c\u4f7fJAK\u86cb\u767d\u6c34\u5e73\u660e\u663e\u4e0b\u964d\u3002\u8fd9\u5c31\u662f\u6000\u5c14\u53d1\u75c5\u8f83\u6162\u7684\u539f\u56e0\uff0c\u5927\u6982\u9700\u8981 4-8 \u5468\u624d\u80fd\u5bf9 JAK\/STAT \u4f9d\u8d56\u6027\u8fc7\u7a0b\u4ea7\u751f\u660e\u663e\u5f71\u54cd\u3002.<\/p>\n\n\n\n<p>\u53e6\u4e00\u4e2a\u91cd\u8981\u533a\u522b\u662f\u53ef\u9006\u6027\u3002\u5f53\u60a3\u8005\u505c\u6b62\u670d\u7528\u4e4c\u8fbe\u66ff\u5c3c\u65f6\uff0c\u7531\u4e8e\u4e4c\u8fbe\u66ff\u5c3c\u7684\u534a\u8870\u671f\u5f88\u77ed\uff0cJAK\u963b\u65ad\u4f5c\u7528\u4f1a\u572824-48\u5c0f\u65f6\u5185\u7ed3\u675f\u3002JAK1\u4f1a\u518d\u6b21\u6d3b\u8dc3\u8d77\u6765\uff0c\u5e76\u4f7fSTAT\u78f7\u9178\u5316\u3002\u5982\u679c\u60a3\u8005\u53d7\u5230\u611f\u67d3\uff0c\u9700\u8981\u6682\u505c\u7528\u836f\uff0c\u8fd9\u5c06\u975e\u5e38\u6709\u7528\uff0c\u4f46\u8fd9\u4e5f\u610f\u5473\u7740\u5fc5\u987b\u6bcf\u5929\u6301\u7eed\u7528\u836f\u3002\u7531\u4e8e\u57fa\u4e8emiRNA\u7684\u8c03\u63a7\u6301\u7eed\u65f6\u95f4\u66f4\u957f\uff0c\u56e0\u6b64Huaier\u7684\u7597\u6548\u53ef\u80fd\u66f4\u6301\u4e45\u3002miRNA \u672c\u8eab\u7684\u534a\u8870\u671f\u6bd4\u5c0f\u5206\u5b50\u8981\u957f\uff0c\u56e0\u6b64\u5728\u505c\u6b62\u670d\u7528\u6000\u5c14\u65f6\uff0cJAK \u86cb\u767d\u7684\u6062\u590d\u9700\u8981\u66f4\u957f\u7684\u65f6\u95f4\u3002.<\/p>\n\n\n\n<p>\u66f4\u5fae\u5999\u7684\u533a\u522b\u5728\u4e8e\u5176\u7279\u5f02\u6027\u3002\u4e4c\u5e15\u4ed6\u66ff\u5c3c\u5177\u6709JAK1\u9009\u62e9\u6027\uff0c\u8fd9\u610f\u5473\u7740\u5b83\u80fd\u5f3a\u6548\u963b\u65adJAK1\uff0c\u5f31\u6548\u963b\u65adJAK2\uff0c\u51e0\u4e4e\u4e0d\u80fd\u963b\u65adJAK3\u3002\u4e8b\u5b9e\u4e0a\uff0c\u8fd9\u6b63\u662fJAK1\u9009\u62e9\u6027\u7684\u76ee\u7684\uff0c\u5373\u907f\u514d\u963b\u65adJAK3\uff0c\u4ee5\u66f4\u597d\u5730\u4fdd\u62a4T\u7ec6\u80de\u529f\u80fd\u3002.<br>Huaier \u53ef\u80fd\u4f1a\u6216\u591a\u6216\u5c11\u5730\u51cf\u5c11 JAK1\u3001JAK2 \u548c TYK2\uff0c\u8fd9\u53d6\u51b3\u4e8e\u54ea\u4e9b miRNA \u88ab\u4e0a\u8c03\u3002\u8fd9\u53ef\u80fd\u610f\u5473\u7740 <strong>\u66f4\u5e7f\u6cdb\u7684 JAK \u6291\u5236<\/strong> \u8fd9\u5bf9 I \u578b IFN \u4fe1\u53f7\uff08\u9700\u8981 TYK2\uff09\u6709\u597d\u5904\uff0c\u4f46\u4e5f\u53ef\u80fd\u5bfc\u81f4\u66f4\u591a\u7684 JAK2 \u6548\u5e94\uff08\u7406\u8bba\u4e0a\u6709\u8840\u6813\u6813\u585e\u98ce\u9669\uff09\u3002.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"PI3KAKT-Aktivierung_Mitochondriale_Restoration_Treg-Support\"><\/span>PI3K\/AKT \u6fc0\u6d3b\uff08\u7ebf\u7c92\u4f53\u6062\u590d+Treg \u652f\u6301\uff09<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>ARLA \u7684\u7b2c\u4e09\u4e2a\u4e3b\u8981\u95ee\u9898\u4e0d\u4ec5\u662f\u4fc3\u708e\u75c7\u7ec6\u80de\u56e0\u5b50\u7684\u6301\u7eed\u4ea7\u751f\uff0c\u8fd8\u5305\u62ec\u901a\u5e38\u9650\u5236\u8fd9\u79cd\u708e\u75c7\u7684\u7cfb\u7edf\u7684\u5d29\u6e83\u3002\u63a7\u5236\u708e\u75c7\u7684\u6700\u91cd\u8981\u7cfb\u7edf\u662f\u8c03\u8282\u6027 T \u7ec6\u80de\uff08T \u7ec6\u80de\uff09\u7fa4\u4f53\u3002<em>\u83cc\u7fa4<\/em>)\uff0c\u7279\u522b\u662f <em>CD4+CD25+Foxp3+ <\/em>Tregs.<\/p>\n\n\n\n<p>\u5728\u5065\u5eb7\u4eba\u4f53\u5185\uff0cTregs \u662f\u514d\u75ab\u7cfb\u7edf\u4e0d\u53ef\u6216\u7f3a\u7684\u4e00\u90e8\u5206\uff0c\u901a\u8fc7\u4ea7\u751f\u6297\u708e\u7ec6\u80de\u56e0\u5b50\uff08\u5982 <em>IL-10<\/em> \u548c <em>TGF-\u03b2<\/em>, \u4ee5\u53ca\u7ec6\u80de\u95f4\u7684\u76f4\u63a5\u63a5\u89e6\uff0c\u4ee5\u6fc0\u6d3b\u4fc3\u708e\u6027 T \u7ec6\u80de (<em>\u6548\u5e94 T \u7ec6\u80de<\/em>)\u5c06\u88ab\u6291\u5236\u3002.<br>\u65b0\u9648\u4ee3\u8c22\u975e\u5e38\u6d3b\u8dc3\uff0c\u5b83\u4eec\u4f9d\u9760\u6c27\u5316\u78f7\u9178\u5316\u4f5c\u7528 <em>\u7ebf\u7c92\u4f53<\/em> \u8fd9\u610f\u5473\u7740\uff0c\u5b83\u4eec\u9700\u8981\u6b63\u5e38\u8fd0\u4f5c\u7684\u7ebf\u7c92\u4f53\u548c\u6e90\u6e90\u4e0d\u65ad\u7684 <em>ATP<\/em>. .\u5b83\u4eec\u8fd8\u9700\u8981\u5408\u6210\u86cb\u767d\u8d28\u7684\u80fd\u529b\uff0c\u7279\u522b\u662f\u751f\u4ea7 <em>\u8f6c\u5f55\u8c03\u8282 <\/em>Foxp3 \u86cb\u767d\u4ee5\u53ca\u6291\u5236\u6027\u7ec6\u80de\u56e0\u5b50 IL-10 \u548c TGF-\u03b2\u3002.<\/p>\n\n\n\n<p>ARLA \u60a3\u8005\u6709\u51e0\u4e2a\u65b9\u9762\u51fa\u4e86\u95ee\u9898\u3002\u9996\u5148\uff0c\u7531\u4e8e TLR2 \u548c TLR7\/8 \u7684\u6301\u7eed\u523a\u6fc0\uff0cARLA \u60a3\u8005\u7684\u514d\u75ab\u7cfb\u7edf\u51fa\u73b0\u4e86\u95ee\u9898\u3002 <strong>\u7ebf\u7c92\u4f53\u957f\u671f\u53d7\u538b<\/strong>. .\u8fde\u7eed\u751f\u4ea7 <em>ROS<\/em> (\u6d3b\u5316\u7684\u708e\u75c7\u7ec6\u80de\u4ea7\u751f\u7684\u6d3b\u6027\u6c27\u4f1a\u6c27\u5316\u7ebf\u7c92\u4f53\u5185\u819c\uff0c\u7834\u574f\u7535\u5b50\u4f20\u9012\u94fe\u4e2d\u7684\u590d\u5408\u7269\u3002\u7ebf\u7c92\u4f53 DNA \u4f1a\u88ab\u6c27\u5316\uff0c\u5bfc\u81f4\u8f6c\u5f55\u7f3a\u9677\u3002\u7ebf\u7c92\u4f53\u6839\u672c\u65e0\u6cd5\u4ea7\u751f\u8db3\u591f\u7684 ATP \u6765\u4f9b\u5e94\u6162\u6027\u708e\u75c7\u72b6\u6001\u4e0b\u7684\u6240\u6709\u7ec6\u80de\u3002.<\/p>\n\n\n\n<p>\u5176\u6b21\uff0c\u901a\u8fc7 <strong>\u6162\u6027 <em>ER \u5e94\u6fc0\u60c5\u51b5<\/em><\/strong> (\u56e0\u4e3a\u708e\u75c7\u7ec6\u80de\u4f1a\u4e0d\u65ad\u4ea7\u751f\u5927\u91cf\u7ec6\u80de\u56e0\u5b50\uff0c\u800c <em>\u86cb\u767d\u8d28\u6298\u53e0\u80fd\u529b<\/em> \u7684 <em>\u5185\u8d28\u7f51<\/em> \u88ab\u6df9\u6ca1\uff09\uff0c\u5219 <em>\u86cb\u767d\u8d28\u5408\u6210\u80fd\u529b<\/em> \u7684\u7ec6\u80de\u6570\u91cf\u5168\u9762\u51cf\u5c11\u3002.<br>\u6838\u7cd6\u4f53\u662f\u751f\u4ea7\u86cb\u767d\u8d28\u7684\u5de5\u5177\uff0c\u5f53\u5185\u8d28\u7f51\u53d7\u5230\u538b\u529b\u65f6\uff0c\u6838\u7cd6\u4f53\u4e5f\u4f1a\u53d7\u5230\u538b\u529b\u3002\u56e0\u6b64\uff0cFoxp3\u3001IL-10 \u548c TGF-\u03b2 \u7b49\u91cd\u8981\u86cb\u767d\u8d28\u65e0\u6cd5\u4ee5\u6700\u4f73\u72b6\u6001\u751f\u6210\u3002.<\/p>\n\n\n\n<p>\u7b2c\u4e09\uff0c\u6240\u6709\u8fd9\u4e9b\u4ee3\u8c22\u95ee\u9898\u90fd\u662f <strong>\u83cc\u7fa4<\/strong> \u7b80\u5355 <strong>\u5931\u7075<\/strong>. .\u867d\u7136\u4ecd\u80fd\u68c0\u6d4b\u5230 Tregs\uff08\u5b83\u4eec\u7684\u6570\u91cf\u751a\u81f3\u7ecf\u5e38\u589e\u52a0\uff09\uff0c\u4f46\u5176\u6291\u5236\u4f5c\u7528\u5374\u5927\u5927\u964d\u4f4e\u3002\u5b83\u4eec\u65e0\u6cd5\u4ea7\u751f\u8db3\u591f\u7684 IL-10\u3002\u56e0\u6b64\uff0cTregs \u65e0\u6cd5\u5145\u5206\u6291\u5236 Th17 \u548c Th1 \u7ec6\u80de\u3002\u7531\u4e8e\u73af\u5883\u4e2d\u7684 IL-10 \u51cf\u5c11\uff0c\u514d\u75ab\u7cfb\u7edf\u7684\u6297\u708e \u201e\u5236\u52a8 \u201c\u4f5c\u7528\u5c31\u65e0\u6cd5\u53d1\u6325\uff0cTh17 \u548c Th1 \u7ec6\u80de\u5c31\u4f1a\u53d7\u5230\u6291\u5236\u3002 <strong>\u4fc3\u708e \u201e\u52a0\u901f\u5ea6 \u201c\u4ecd\u88ab\u6fc0\u6d3b<\/strong>.<\/p>\n\n\n\n<p><strong>\u6000\u5c14\u5982\u4f55\u6fc0\u6d3b\/\u6062\u590d\u8fd9\u4e00\u8fc7\u7a0b\uff1a<\/strong><\/p>\n\n\n\n<p>\u6000\u5c14\u901a\u8fc7 <em>PI3K\/AKT \u4fe1\u53f7\u8def\u5f84<\/em> \u4e0a\u3002\u5f53\u6000\u5c14\u591a\u7cd6\u4e0e Dectin-1 \u53d7\u4f53\u7ed3\u5408\u65f6\uff0c\u4e0d\u4ec5\u4f1a\u6fc0\u6d3b NF-\u03baB \u548c\u5e72\u6270\u7d20\u901a\u8def\uff0c\u8fd8\u4f1a\u6fc0\u6d3b PI3K\uff08\u78f7\u8102\u9170\u808c\u9187 3-\u6fc0\u9176\uff09\u3002PI3K \u50ac\u5316\u78f7\u8102\u9170\u808c\u9187-(4,5)-\u4e8c\u78f7\u9178\uff08PI3K\uff09\u7684\u78f7\u9178\u5316\u3002<em>PIP2<\/em>)\u8f6c\u5316\u4e3a\u78f7\u8102\u9170\u808c\u9187-(3,4,5)-\u4e09\u78f7\u9178\u916f(<em>PIP3<\/em>).PIP3 \u662f\u4e00\u79cd \u201e\u7b2c\u4e8c\u4fe1\u4f7f\u201c--\u4e00\u79cd\u80fd\u5438\u5f15\u5176\u4ed6\u86cb\u767d\u8d28\u7684\u7ec6\u80de\u5185\u4fe1\u53f7\u5206\u5b50\u3002.<\/p>\n\n\n\n<p>\u88ab PIP3 \u5438\u5f15\u7684\u86cb\u767d\u8d28\u662f <em>ACT<\/em> (\u53c8\u79f0\u86cb\u767d\u6fc0\u9176 B\uff09\u3002AKT \u7531 3-\u78f7\u9178\u808c\u9187\u4f9d\u8d56\u6027\u86cb\u767d\u6fc0\u9176 1\uff083-phosphoinositide-dependent protein kinase 1\uff09\u4ea7\u751f\u3002<em>PDK1<\/em>) \u78f7\u9178\u5316\u5e76\u6fc0\u6d3b\u3002\u4e00\u65e6\u6fc0\u6d3b\uff0cAKT \u5c31\u662f\u8bb8\u591a\u7ec6\u80de\u8fc7\u7a0b\u7684 \u201e\u4e3b\u8c03\u8282\u5668\u201c\u3002\u5c31 ARLA \u800c\u8a00\uff0cAKT \u7684\u4e24\u4e2a\u529f\u80fd\u5c24\u4e3a\u91cd\u8981\uff1a<\/p>\n\n\n\n<p>\u9996\u5148\u662f, <strong>AKT \u6fc0\u6d3b mTOR<\/strong> (\u96f7\u5e15\u9709\u7d20\u673a\u68b0\u9776\u6807\uff09\uff0c\u8fd9\u662f\u4e00\u79cd\u63a7\u5236 mRNA \u7ffb\u8bd1\u548c\u6838\u7cd6\u4f53\u751f\u7269\u751f\u6210\u7684\u5927\u578b\u86cb\u767d\u8d28\u590d\u5408\u7269\u3002.<br>\u5f53 AKT \u6fc0\u6d3b mTOR \u65f6\uff0c\u4f1a\u53d1\u751f\u4e24\u4ef6\u4e8b\uff1a\uff081\uff09mTOR \u4f7f AKT \u78f7\u9178\u5316\uff1b\uff082\uff09AKT \u4f7f mTOR \u78f7\u9178\u5316\u3002 <em>S6K<\/em> (\u6838\u7cd6\u4f53 S6 \u6fc0\u9176\uff09\uff0c\u4f7f\u6838\u7cd6\u4f53\u4e2d\u7684 S6 \u86cb\u767d\u78f7\u9178\u5316\uff0c\u4ece\u800c\u63d0\u9ad8\u7ffb\u8bd1\u6548\u7387\u3002(2) mTOR \u8fd8\u80fd\u78f7\u9178\u5316 <em>4E-BP1<\/em> (4E-Binding Protein 1)\uff0c\u5b83\u80fd\u4f7f 4E-BP1 \u7ed3\u5408\u5230 <em>eIF4E<\/em> \u4ece\u800c\u589e\u52a0\u4f9d\u8d56\u4e8e eIF4E \u7684 mRNA \u7684\u7ffb\u8bd1\u3002.<br>\u6700\u7ec8\u7ed3\u679c\u662f\uff0c\u7ec6\u80de\u80fd\u5728\u66f4\u77ed\u7684\u65f6\u95f4\u5185\u4ea7\u751f\u66f4\u591a\u7684\u86cb\u767d\u8d28\u3002\u5bf9\u4e8e <strong>\u83cc\u7fa4<\/strong> \u8fd9\u610f\u5473\u7740\u4ed6\u4eec\u73b0\u5728\u53ef\u4ee5 <strong>\u53ef\u6700\u4f73\u5730\u4ea7\u751f IL-10 \u548c Foxp3<\/strong>, \u6240\u9700\u7684\u86cb\u767d\u8d28\u3001, <strong>\u8d77\u5230\u6291\u5236\u4f5c\u7528<\/strong>.<\/p>\n\n\n\n<p>\u5176\u6b21\u662f, <strong>AKT \u6fc0\u6d3b\u65b0\u7ebf\u7c92\u4f53\u7684\u751f\u7269\u751f\u6210<\/strong>. .\u90e8\u5206\u539f\u56e0\u662f AKT \u6fc0\u6d3b\u4e86 PGC1\u03b1 \u57fa\u56e0\u3002.<br>PGC1\u03b1 \u662f\u7ebf\u7c92\u4f53\u751f\u7269\u751f\u6210\u8fc7\u7a0b\u4e2d\u6240\u8c13\u7684 \u201e\u4e3b\u8c03\u8282\u5668\u201c\u3002\u5b83\u662f\u4e00\u79cd\u534f\u540c\u6fc0\u6d3b\u56e0\u5b50\uff0c\u4e0e\u51e0\u79cd\u8f6c\u5f55\u56e0\u5b50\u4e00\u8d77\u6fc0\u6d3b\u7f16\u7801\u7ebf\u7c92\u4f53\u86cb\u767d\u8d28\u7684\u57fa\u56e0\u3002. <br>\u901a\u8fc7\u79ef\u6781\u7684 <em>PGC1\u03b1<\/em> \u7ec6\u80de\u4e2d\u4f1a\u4ea7\u751f\u65b0\u7684\u7ebf\u7c92\u4f53\u3002\u5728\u6570\u5468\u7684\u65f6\u95f4\u91cc\uff0c\u8fd9\u610f\u5473\u7740 Tregs \u53ef\u4ee5\u66f4\u65b0\u5176\u7ebf\u7c92\u4f53\u6570\u91cf\uff0c\u8001\u7684\u3001\u53d7\u635f\u7684\u7ebf\u7c92\u4f53\u88ab\u65b0\u7684\u3001\u529f\u80fd\u6027\u7684\u7ebf\u7c92\u4f53\u6240\u53d6\u4ee3\uff0c\u800c\u7ec6\u80de\u4e2d\u7684\u7ebf\u7c92\u4f53\u4e5f\u4f1a\u968f\u4e4b\u66f4\u65b0\u3002 <strong>\u6062\u590dTregs\u4ea7\u751fATP\u7684\u80fd\u529b<\/strong>.<\/p>\n\n\n\n<p>\u968f\u7740\u7ebf\u7c92\u4f53\u529f\u80fd\u7684\u6539\u5584\u548c\u86cb\u767d\u8d28\u5408\u6210\u7684\u63d0\u9ad8\uff0cTregs \u6062\u590d\u4e86\u6709\u6548\u5de5\u4f5c\u7684\u80fd\u529b\u3002\u5b83\u4eec\u53ef\u4ee5\u518d\u6b21\u4ea7\u751f\u5927\u91cf\u7684 IL-10\u3002\u6ed1\u6db2\u4e2d\u7684IL-10\u53ef\u4ee5\u6291\u5236Th17\u7ec6\u80de\uff0c\u6291\u5236Th1\u7ec6\u80de\uff0c\u89e3\u51b3\u6162\u6027\u81ea\u8eab\u514d\u75ab\u95ee\u9898\u3002.<\/p>\n\n\n\n<p>\u8fd9\u662f\u4e00\u4e2a\u7f13\u6162\u7684\u8fc7\u7a0b\uff0c\u65b0\u7ebf\u7c92\u4f53\u7684\u751f\u7269\u751f\u6210\u9700\u8981\u6570\u5468\u65f6\u95f4\uff0c\u4f46\u53ef\u4ee5\u6301\u7eed\u3002\u6000\u5c14\u5bf9 NF-\u03baB \u7684\u6291\u5236\u5177\u6709\u5feb\u901f\u6548\u5e94\uff08\u6570\u5929\uff09\uff0c\u800c\u5bf9 JAK\/STAT \u7684\u8c03\u8282\u5219\u5177\u6709\u4e2d\u671f\u6548\u5e94\uff08\u6570\u5468\uff09\u3002 <em>PI3K\/AKT \u6fc0\u6d3b<\/em> \u957f\u671f\u5e72\u9884\uff0c\u8fd9\u4e0d\u4f1a\u4ece\u6839\u672c\u4e0a\u6539\u53d8 <strong>\u6062\u590d\u514d\u75ab\u8010\u53d7\u7684\u4ee3\u8c22\u6761\u4ef6<\/strong>.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Spezifische_Effekte_bei_ARLA\"><\/span><br><strong>ARLA \u7684\u5177\u4f53\u6548\u679c\uff1a<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u5728\u6000\u5c14\u7597\u6cd5\u4e4b\u524d\u7684\u57fa\u7840\u72b6\u6001\u4e0b\uff0cARLA \u60a3\u8005\u6709\u51e0\u4e2a\u75c5\u7406\u7279\u5f81\u3002\u9996\u5148\uff0c\u6ed1\u819c\u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de\u548c T \u7ec6\u80de\u4e2d\u7684\u7ebf\u7c92\u4f53\u957f\u671f\u53d7\u5230\u653b\u51fb\u3002\u7535\u5b50\u4f20\u9012\u94fe\u65e0\u6cd5\u53d1\u6325\u6700\u4f73\u529f\u80fd\uff0cATP \u5408\u6210\u51cf\u5c11\u3002\u8fd9\u53ef\u4ee5\u901a\u8fc7\u4ee3\u8c22\u6d4b\u8bd5\u6765\u8bc1\u660e\uff0c\u4f8b\u5982 <em>\u6d77\u9a6c\u5206\u6790<\/em> (\u6d4b\u91cf\u5b9e\u9645 ATP \u751f\u6210\u7387\uff09\u3002\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0cARLA \u60a3\u8005\u7684 OXPHOS \u7387\u8f83\u4f4e\u3002.<\/p>\n\n\n\n<p>\u5176\u6b21\uff0c\u8c03\u8282\u6027 T \u7ec6\u80de\uff08Tregs\uff09\u6570\u91cf\u4f17\u591a\u3002\u5b83\u4eec\u53ef\u4ee5\u901a\u8fc7 <em>\u6d41\u5f0f\u7ec6\u80de\u4eea<\/em> CD4+CD25+Foxp3+\u6807\u8bb0\u3002ARLA\u60a3\u8005\u7684Tregs\u7edd\u5bf9\u6570\u91cf\u901a\u5e38\u4f1a\u589e\u52a0\uff0c\u6709\u65f6\u751a\u81f3\u9ad8\u4e8e\u5065\u5eb7\u4eba\u3002\u4eba\u4eec\u672c\u4ee5\u4e3a\u66f4\u591a\u7684\u96c6\u843d\u7ec6\u80de\u4f1a\u5e26\u6765\u66f4\u597d\u7684\u6291\u5236\u4f5c\u7528\uff0c\u4f46\u4e8b\u5b9e\u6070\u6070\u76f8\u53cd\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u96c6\u843d\u7ec6\u80de\u529f\u80fd\u5931\u8c03\u3002\u5b83\u4eec\u6bcf\u4e2a\u7ec6\u80de\u4ea7\u751f\u7684 IL-10 \u8f83\u5c11\uff0c\u6291\u5236\u6d3b\u6027\u8f83\u4f4e\uff0c\u56e0\u6b64\u65e0\u6cd5\u6709\u6548\u63a7\u5236\u81ea\u53cd\u5e94 T \u7ec6\u80de\u3002.<\/p>\n\n\n\n<p>\u7b2c\u4e09\uff0cIL-10\/IFN-\u03b3 \u7684\u6bd4\u4f8b\u4e25\u91cd\u5931\u8861\u3002\u5728\u5065\u5eb7\u4eba\u4e2d\uff0cIL-10 \u901a\u5e38\u81f3\u5c11\u4e0e IFN-\u03b3 \u4e00\u6837\u9ad8\uff0c\u751a\u81f3\u66f4\u9ad8\u3002\u5728 ARLA \u60a3\u8005\u4e2d\uff0cIFN-\u03b3 \u9ad8\u5ea6\u5347\u9ad8\uff08\u6ed1\u819c\u6db2\u4e2d\u7684 IFN-\u03b3 \u6bd4\u5065\u5eb7\u4eba\u9ad8\u51fa\u6570\u767e\u500d\uff09\uff0c\u800c IL-10 \u5374\u5f88\u4f4e\u3002\u8fd9\u79cd\u4e0d\u5e73\u8861\u53ef\u80fd\u662f ARLA \u4e25\u91cd\u7a0b\u5ea6\u7684\u6700\u4f73\u751f\u7269\u5b66\u6807\u5fd7\u4e4b\u4e00\u3002.<\/p>\n\n\n\n<p>\u7b2c\u56db\uff0c\u81ea\u8eab\u6297\u4f53\u6ef4\u5ea6\u5347\u9ad8\u3002\u8fd9\u53ef\u80fd\u662f <em>\u6297 OspA \u6297\u4f53<\/em> (\u9488\u5bf9\u5305\u67d4\u6c0f\u83cc\u6297\u539f\u7684\u6297\u4f53\uff0c\u4f46\u53cd\u5e94\u6301\u7eed\u5b58\u5728\uff09\u3001\u9488\u5bf9\u4eba\u4f53\u81ea\u8eab\u8f6f\u9aa8\u86cb\u767d\u7684\u6297\u4f53\uff0c\u5982 <em>II \u578b\u80f6\u539f\u86cb\u767d<\/em> \u548c <em>\u963f\u683c\u96f7\u5eb7<\/em>, \u6709\u65f6\u4e5f <em>\u7c7b\u98ce\u6e7f\u56e0\u5b50<\/em> \u548c <em>\u6297 CCP \u6297\u4f53<\/em>.<\/p>\n\n\n\n<p>\u5728\u5f00\u59cb\u4f7f\u7528\u6bcf\u5929 20 \u514b\u7684\u6000\u5c14\u7597\u6cd5\u540e\uff0c\u7ecf\u8fc7\u51e0\u5468\u5230\u51e0\u4e2a\u6708\u7684\u65f6\u95f4\uff0c\u6211\u4eec\u770b\u5230\u4e86\u4ee5\u4e0b\u53d8\u5316\uff1a<\/p>\n\n\n\n<p>\"(\u300a\u4e16\u754c\u4eba\u6743\u5ba3\u8a00\u300b) <strong>\u7ebf\u7c92\u4f53\u547c\u5438\u6062\u590d\u6b63\u5e38<\/strong>. .\u8fd9\u53ef\u4ee5\u901a\u8fc7\u6d77\u9a6c\u5206\u6790\u6cd5\u6765\u6d4b\u91cf\u3002\u6d77\u9a6c <strong><em>\u57fa\u7840\u547c\u5438<\/em> \u548c ATP \u751f\u6210\u7387\u589e\u52a0\u5230\u6b63\u5e38\u503c<\/strong>. .\u8fd9\u662f\u53ef\u4ee5\u6d4b\u91cf\u548c\u91cd\u590d\u7684\u3002\u5982\u4e0a\u6240\u8ff0\uff0c\u5176\u673a\u5236\u662f PI3K\/AKT \u901a\u8fc7 PGC1\u03b1 \u8bf1\u5bfc\u4ecb\u5bfc\u7ebf\u7c92\u4f53\u751f\u7269\u751f\u6210\u3002.<\/p>\n\n\n\n<p>\"(\u300a\u4e16\u754c\u4eba\u6743\u5ba3\u8a00\u300b) <strong>Tregs \u53d8\u5f97\u6709\u529f\u80fd<\/strong>. .\u8fd9\u4e00\u70b9\u6bd4\u8f83\u96be\u4ee5\u6d4b\u91cf\uff0c\u4f46\u6709\u51e0\u79cd\u9014\u5f84\uff1a\u6bcf\u4e2a Treg \u4ea7\u751f\u7684 IL-10 \u589e\u52a0\uff08\u53ef\u901a\u8fc7\u7ec6\u80de\u5185\u7ec6\u80de\u56e0\u5b50\u67d3\u8272\u548c\u6d41\u5f0f\u7ec6\u80de\u672f\u6d4b\u91cf\uff09\u3002Foxp3 \u8868\u8fbe\u589e\u52a0\uff08\u6bcf\u4e2a\u7ec6\u80de\u542b\u6709\u66f4\u591a\u7684 Foxp3 \u86cb\u767d\uff09\u3002\u4f53\u5916\u6291\u5236\u529f\u80fd\u53ef\u901a\u8fc7\u6291\u5236\u8bd5\u9a8c\u6d4b\u5b9a\u3002\u5f53 ARLA \u60a3\u8005\u7684\u96c6\u843d\u7ec6\u80de\u4e0e\u81ea\u53cd\u5e94 T \u7ec6\u80de\u5171\u540c\u57f9\u517b\u65f6\uff0c\u96c6\u843d\u7ec6\u80de\u5728\u63a5\u53d7\u6000\u5c14\u7597\u6cd5\u540e\u80fd\u66f4\u597d\u5730\u6291\u5236 T \u7ec6\u80de\u589e\u6b96\u3002.<\/p>\n\n\n\n<p>\"(\u300a\u4e16\u754c\u4eba\u6743\u5ba3\u8a00\u300b) <strong>IL-10\/IFN-\u03b3 \u6bd4\u7387\u663e\u8457\u6062\u590d\u6b63\u5e38<\/strong>. .IFN-\u03b3 \u7684\u6c34\u5e73\u901a\u5e38\u4f1a\u4e0b\u964d 50-70%\uff0c\u800c IL-10 \u7684\u6c34\u5e73\u5219\u4f1a\u4e0a\u5347 100-200%\u3002\u8fd9\u6837\uff0c\u4e24\u8005\u7684\u6bd4\u4f8b\u770b\u8d77\u6765\u5c31\u6062\u590d\u4e86\u6b63\u5e38\uff0c\u4e0d\u518d\u662f\u75c5\u7406\u4e0a\u7684 1:100\uff0c\u800c\u662f\u63a5\u8fd1 1:1\uff0c\u751a\u81f3\u4ee5 IL-10 \u4e3a\u4e3b\u5bfc\u3002.<\/p>\n\n\n\n<p>\"(\u300a\u4e16\u754c\u4eba\u6743\u5ba3\u8a00\u300b) <strong>\u81ea\u8eab\u6297\u4f53\u6ef4\u5ea6\u964d\u4f4e<\/strong>. .\u8fd9\u9700\u8981\u8f83\u957f\u7684\u65f6\u95f4\uff0c\u901a\u5e38\u4e3a 8-12 \u5468\uff0c\u4f46\u6297\u4f53\u6ef4\u5ea6\u4f1a\u6301\u7eed\u4e0b\u964d\u3002\u6297 OspA \u6297\u4f53\u9996\u5148\u4e0b\u964d\uff0c\u6297\u4eba\u4f53\u81ea\u8eab\u8f6f\u9aa8\u86cb\u767d\u7684\u6297\u4f53\u968f\u540e\u4e0b\u964d\u3002\u8fd9\u662f B \u7ec6\u80de\u53cd\u5e94\u56e0 T \u7ec6\u80de\u63a7\u5236\u6b63\u5e38\u5316\u800c\u4e0b\u964d\u7684\u8ff9\u8c61\uff08Tregs \u53ef\u6291\u5236 B \u7ec6\u80de\u53cd\u5e94\uff09\u3002.<\/p>\n\n\n\n<p>\"(\u300a\u4e16\u754c\u4eba\u6743\u5ba3\u8a00\u300b) <strong>\u5173\u8282\u79ef\u6db2\u51cf\u5c11<\/strong>. .\u8fd9\u662f\u6700\u660e\u663e\u7684\u4f53\u5f81\uff0c\u53ef\u901a\u8fc7\u4e34\u5e8a\u68c0\u67e5\u3001\u5468\u5f84\u6d4b\u91cf\u6216\u8d85\u58f0\u6ce2\u6765\u6d4b\u91cf\u3002\u968f\u7740IL-10\u7684\u589e\u52a0\u548cTNF-\u03b1\/IL-6\u7684\u51cf\u5c11\uff0c\u767d\u7ec6\u80de\u8fdb\u5165\u5173\u8282\u7684\u8d8b\u5316\u4f5c\u7528\u4f1a\u51cf\u5f31\uff0c\u73b0\u6709\u7684\u6e17\u51fa\u7269\u4f1a\u88ab\u91cd\u65b0\u5438\u6536\u3002200-300 \u6beb\u5347\u7684\u6e17\u51fa\u6db2\u53ef\u51cf\u5c11\u5230 50-100 \u6beb\u5347\u6216\u5b8c\u5168\u6d88\u5931\u3002.<\/p>\n\n\n\n<p>\"(\u300a\u4e16\u754c\u4eba\u6743\u5ba3\u8a00\u300b) <strong>\u4e34\u5e8a\u75c7\u72b6\u76f8\u5e94\u6539\u5584<\/strong>\u75bc\u75db\u51cf\u8f7b\uff0c\u6d3b\u52a8\u80fd\u529b\u589e\u5f3a\uff0c\u60a3\u8005\u53ef\u4ee5\u91cd\u65b0\u4f7f\u7528\u81ea\u5df1\u7684\u5173\u8282\u3002\u751f\u6d3b\u8d28\u91cf\u663e\u8457\u63d0\u9ad8\u3002\u8bb8\u591a ARLA \u60a3\u8005\u8868\u793a\uff0c\u4ed6\u4eec\u591a\u5e74\u6765\u7b2c\u4e00\u6b21\u53ef\u4ee5\u91cd\u65b0\u8fdb\u884c\u6b63\u5e38\u7684\u65e5\u5e38\u6d3b\u52a8\uff08\u722c\u697c\u68af\u3001\u8d2d\u7269\u3001\u8fd0\u52a8\uff09\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Ribosomale_Homoostase_Tanaka-Hauptfund\"><\/span>\u6838\u7cd6\u4f53\u5e73\u8861\uff08\u7530\u4e2d\u7684\u4e3b\u8981\u53d1\u73b0\uff09<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u57fa\u4e8e\u7530\u4e2d\u6838\u7cd6\u4f53\u529f\u80fd\u969c\u788d\u7684\u7814\u7a76\uff0c\u7b2c\u56db\u4e2a\u5e72\u9884\u70b9\u5f88\u5fae\u5999\uff0c\u4f46\u53ef\u80fd\u5f88\u5173\u952e\u3002\u5047\u8bbe\u5982\u4e0b\uff1a\u5728 ARLA \u4e2d\uff0c\u6162\u6027\u3001\u6301\u7eed\u7684 TLR2 \u548c TLR7\/8 \u4fe1\u53f7\u5bfc\u81f4\u6162\u6027 ER \u538b\u529b\u3002\u5185\u8d28\u7f51\uff08ER\uff09\u5fc5\u987b\u4e0d\u65ad\u6298\u53e0\u5e76\u91ca\u653e\u5927\u91cf\u65b0\u7684\u7ec6\u80de\u56e0\u5b50\u548c\u8d8b\u5316\u56e0\u5b50\uff0c\u56e0\u6b64\u5176\u86cb\u767d\u9176\u7cfb\u7edf\u4e0d\u65ad\u8d85\u8d1f\u8377\u8fd0\u8f6c\u3002.<\/p>\n\n\n\n<p>\u5f53\u5185\u8d28\u7f51\u957f\u671f\u5904\u4e8e\u538b\u529b\u4e4b\u4e0b\u65f6\uff0c\u7ec6\u80de\u5c31\u4f1a\u505a\u51fa\u6240\u8c13\u7684 \u201e\u672a\u6298\u53e0\u86cb\u767d\u8d28\u53cd\u5e94\u201c\uff08unfolded protein response\uff09\u3002<em>\u666e\u904d\u5b9a\u671f\u5ba1\u8bae<\/em>).UPR \u662f\u4e00\u79cd\u751f\u5b58\u673a\u5236\uff0c\u4f46\u5982\u679c\u5b83\u88ab\u957f\u671f\u6fc0\u6d3b\uff0c\u5c31\u4f1a\u4ea7\u751f\u95ee\u9898\u3002.<br>UPR \u7684\u4e00\u4e2a\u73af\u8282\u662f\u78f7\u9178\u5316 <em>eIF2\u03b1<\/em> (\u771f\u6838\u7ec6\u80de\u542f\u52a8\u56e0\u5b50 2\u03b1\uff09\uff0c\u7531 <em>HRI<\/em> (\u8840\u7ea2\u7d20\u8c03\u8282\u6291\u5236\u6fc0\u9176\uff09\u6216\u5176\u4ed6\u6fc0\u9176\u3002\u5f53 eIF2\u03b1 \u88ab\u78f7\u9178\u5316\u65f6\uff0c\u86cb\u767d\u8d28\u5408\u6210\u7684\u603b\u4f53\u901f\u7387\u5c31\u4f1a\u964d\u4f4e\u3002\u8fd9\u662f\u9002\u5e94\u6027\u7684\uff0c\u56e0\u4e3a\u5982\u679c ER \u5df2\u7ecf\u8d85\u8d1f\u8377\uff0c\u7ec6\u80de\u5c31\u4e0d\u5e94\u8be5\u518d\u6298\u53e0\u66f4\u591a\u7684\u86cb\u767d\u8d28\u3002.<\/p>\n\n\n\n<p>\u5f53 <em>\u86cb\u767d\u8d28\u5408\u6210\u7387<\/em> \u968f\u7740\u514d\u75ab\u8010\u53d7\u6027\u7684\u6574\u4f53\u964d\u4f4e\uff0c\u901a\u5e38\u4e3a\u7ef4\u6301\u514d\u75ab\u8010\u53d7\u6027\u800c\u5fc5\u987b\u6301\u7eed\u4ea7\u751f\u7684\u86cb\u767d\u8d28\u4e5f\u65e0\u6cd5\u4ee5\u6700\u4f73\u72b6\u6001\u4ea7\u751f\u3002\u8fd9\u4e9b\u86cb\u767d\u8d28\u5305\u62ec IL-10\u3001TGF-\u03b2 \u548c Foxp3\u3002\u8fd9\u4e9b\u86cb\u767d\u8d28\u76f8\u5bf9\u8f83\u5927\uff0c\u7ed3\u6784\u590d\u6742\uff0c\u9700\u8981\u7279\u6b8a\u7684\u6838\u7cd6\u4f53\u8d28\u91cf\u624d\u80fd\u8fbe\u5230\u6700\u4f73\u6298\u53e0\u72b6\u6001\u3002.<\/p>\n\n\n\n<p>\u6b64\u5916\uff0c\u6838\u7cd6\u4f53\u672c\u8eab\u4e5f\u4f1a\u5728 ER \u538b\u529b\u4e0b\u53d7\u635f\u3002\u5927\u6838\u7cd6\u4f53\u4e9a\u57fa\uff08<em>60S<\/em>)\u548c\u5c0f\u6838\u7cd6\u4f53\u4e9a\u57fa(<em>40S<\/em>)\u5177\u6709\u590d\u6742\u7684\u7ed3\u6784\u548c\u7ec4\u6210\u3002.<br>\u5f53 ER \u53d7\u5230\u538b\u529b\uff0c\u7ec6\u80de\u4ea7\u751f\u8fc7\u591a\u6298\u53e0\u9519\u8bef\u7684\u86cb\u767d\u8d28\u65f6\uff0c\u6298\u53e0\u9519\u8bef\u7684\u86cb\u767d\u8d28\u5c31\u4f1a\u4e0e\u6838\u7cd6\u4f53\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u5e76\u5bf9\u5176\u9020\u6210\u7834\u574f\uff0c\u8fdb\u800c\u5bfc\u81f4\u6838\u7cd6\u4f53 RNA \u7ed3\u6784\u5f02\u5e38\uff0c\u6b63\u5982 Tanaka \u5728\u5176 mRNA \u75ab\u82d7\u63a5\u79cd\u7814\u7a76\u4e2d\u6240\u63cf\u8ff0\u7684\u90a3\u6837\u3002.<\/p>\n\n\n\n<p>\u5982\u679c\u6838\u7cd6\u4f53\u5728\u7ed3\u6784\u4e0a\u53d7\u635f\uff0c\u5b83\u4eec\u4ecd\u80fd\u53d1\u6325\u4f5c\u7528\uff0c\u4f46\u4e0d\u80fd\u8fbe\u5230\u6700\u4f73\u72b6\u6001\u3002\u8fd9\u53ef\u80fd\u5bfc\u81f4<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7ffb\u8bd1\u9519\u8bef<\/li>\n\n\n\n<li>\u86cb\u767d\u8d28\u5408\u6210\u6548\u7387\u4f4e\u4e0b<\/li>\n\n\n\n<li>\u6709\u7f3a\u9677\u7684\u86cb\u767d\u8d28\uff0c\u5c24\u5176\u662f\u7ed3\u6784\u590d\u6742\u7684\u86cb\u767d\u8d28\uff0c\u5982 IL-10<\/li>\n<\/ul>\n\n\n\n<p>\u8fd9\u4f7f\u5f97\u95ee\u9898\u81ea\u6211\u5ef6\u7eed\uff1a\u6838\u7cd6\u4f53\u4e0d\u8db3\u2192IL-10 \u5408\u6210\u4e0d\u8db3\u2192\u73af\u5883\u4e2d\u7684 IL-10 \u51cf\u5c11\u2192\u514d\u75ab\u8010\u53d7\u6027\u964d\u4f4e\u2192\u708e\u75c7\u52a0\u5267\u3002.<\/p>\n\n\n\n<p><strong>\u6000\u5c14\u662f\u5982\u4f55\u4fee\u590d\u8fd9\u4e00\u8fc7\u7a0b\u7684\uff1a<\/strong><\/p>\n\n\n\n<p>Huaier \u901a\u8fc7 miRNA \u4ecb\u5bfc\u7684\u8c03\u63a7\u6765\u89e3\u51b3\u6838\u7cd6\u4f53\u5e73\u8861\u95ee\u9898\u3002\u7530\u4e2d\u4ecb\u7ecd\u8bf4 <strong>\u6000\u5c14<\/strong> \u901a\u8fc7\u4e0a\u8c03\u7279\u5b9a\u7684 miRNAs <strong>\u6838\u7cd6\u4f53 RNA \u7ec4\u6210\u548c\u7ed3\u6784\u6b63\u5e38\u5316<\/strong>. .\u8fd9\u53ef\u4ee5\u901a\u8fc7\u4ee5\u4e0b\u673a\u5236\u5b9e\u73b0\uff1a<\/p>\n\n\n\n<p>\u9996\u5148\uff0c\u6000\u5c14\u8bf1\u5bfc\u7684\u7279\u5b9a miRNA \u53ef\u6291\u5236\u4e0e\u6838\u7cd6\u4f53\u529f\u80fd\u969c\u788d\u6709\u5173\u7684\u86cb\u767d\u8d28\u7684\u8868\u8fbe\u3002\u4f8b\u5982\uff0cmiRNA \u53ef\u51cf\u5c11\u6838\u7cd6\u4f53\u4e2d\u9519\u8bef\u6298\u53e0\u86cb\u767d\u8d28\u7684\u8868\u8fbe\u3002.<\/p>\n\n\n\n<p>\u5176\u6b21\uff0c\u6000\u5c14 <strong>\u6fc0\u6d3b\u81ea\u566c\u548c\u86cb\u767d\u9176\u4f53<\/strong>, \u964d\u89e3\u53d7\u635f\u7684\u6838\u7cd6\u4f53\u86cb\u767d\u548c\u65e7\u6838\u7cd6\u4f53\u3002\u8fd9\u90e8\u5206\u662f\u901a\u8fc7 miRNA \u5bf9\u81ea\u566c\u57fa\u56e0\u7684\u8c03\u63a7\u6765\u5b9e\u73b0\u7684\u3002\u6fc0\u6d3b\u81ea\u566c\u540e\uff0c\u7ec6\u80de\u4e2d\u7684\u8001\u65e7\u3001\u53d7\u635f\u6838\u7cd6\u4f53\u5c31\u4f1a\u88ab\u6e05\u9664\u3002.<\/p>\n\n\n\n<p>\u7b2c\u4e09\uff0cHuaier \u6fc0\u6d3b\u7684 PI3K\/AKT\uff08\u6211\u4eec\u5728\u4e0a\u4e00\u70b9\u4e2d\u8ba8\u8bba\u8fc7\uff09 <strong>\u6fc0\u6d3b mTOR<\/strong>, \u8fd9\u4e0d\u4ec5\u80fd\u523a\u6fc0\u7ffb\u8bd1\uff0c\u8fd8\u80fd\u523a\u6fc0\u65b0\u6838\u7cd6\u4f53\u7684\u751f\u7269\u751f\u6210\u3002\u8fd9\u610f\u5473\u7740\uff0c\u5f53\u65e7\u7684\u6838\u7cd6\u4f53\u88ab\u81ea\u566c\u6e05\u9664\u65f6\u3001, <strong>\u65b0\u7684\u529f\u80fd\u6027\u6838\u7cd6\u4f53<\/strong> \u901a\u8fc7 mTOR \u4f9d\u8d56\u6027 rRNA \u5408\u6210\u548c\u6838\u7cd6\u4f53\u86cb\u767d\u8868\u8fbe <strong>\u4ea7\u751f<\/strong>.<\/p>\n\n\n\n<p>\u51e0\u5468\u540e\u7684\u7ed3\u679c\u662f <strong>\u6838\u7cd6\u4f53\u6570\u91cf\u6b63\u5e38\u5316<\/strong>. .\u7ec6\u80de\u73b0\u5728\u62e5\u6709\u4e86\u7ed3\u6784\u6b63\u786e\u7684\u529f\u80fd\u6027\u6838\u7cd6\u4f53\u3002\u8fd9\u610f\u5473\u7740 IL-10\u3001TGF-\u03b2 \u548c Foxp3 \u53ef\u4ee5\u91cd\u65b0\u4ee5\u6700\u4f73\u65b9\u5f0f\u5408\u6210\u3002\u7ec6\u80de <strong>\u86cb\u767d\u8d28<\/strong>, \u4ea7\u751f\u7684\u662f <strong>\u7ed3\u6784\u6b63\u786e\uff0c\u529f\u80fd\u6709\u6548<\/strong>.<\/p>\n\n\n\n<p>\u8fd9\u662f\u6000\u5c14\u6700\u5fae\u5999\u4e5f\u53ef\u80fd\u662f\u6700\u7f13\u6162\u7684\u5e72\u9884\u63aa\u65bd\u3002\u5b8c\u5168\u6062\u590d\u6838\u7cd6\u4f53\u8d28\u91cf\u9700\u8981 4-8 \u5468\u6216\u66f4\u957f\u7684\u65f6\u95f4\u3002\u8fd9\u4e00\u70b9\u81f3\u5173\u91cd\u8981\uff0c\u56e0\u4e3a\u5b83\u80fd\u6062\u590d\u7ec6\u80de\u4ea7\u751f\u514d\u75ab\u8010\u53d7\u6240\u5fc5\u9700\u7684\u86cb\u767d\u8d28\u7684\u80fd\u529b\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Mechanistischer_Vergleich_Huaier_zu_Biologika\"><\/span>\u6000\u5c14\u4e0e\u751f\u7269\u5236\u5242\u7684\u673a\u7406\u6bd4\u8f83<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u65b9\u9762<\/th><th>TNFi<\/th><th>IL-6i<\/th><th>JAK1i<\/th><th>\u60e0\u5c14<\/th><\/tr><\/thead><tbody><tr><td><strong>NF-\u03baB \u53d7\u963b<\/strong><\/td><td>\u95f4\u63a5\uff08\u2193TNF\uff09<\/td><td>\u95f4\u63a5\uff08\u2193IL-6\uff09<\/td><td>\u95f4\u63a5\uff08\u2193JAK1\uff09<\/td><td>\u76f4\u63a5\uff08\u6291\u5236 NF-\u03baB\uff09<\/td><\/tr><tr><td><strong>JAK\/STAT \u53d7\u963b<\/strong><\/td><td>\u6ca1\u6709<\/td><td>\u90e8\u5206\uff08IL-6 \u9014\u5f84\uff09<\/td><td>\u662f\uff08\u975e\u5e38\u5f3a\u70c8\uff09<\/td><td>JA\uff08\u901a\u8fc7 miRNA\uff0c\u8f83\u5f31\uff09<\/td><\/tr><tr><td><strong>PI3K\/AKT \u6fc0\u6d3b<\/strong><\/td><td>\u6ca1\u6709<\/td><td>\u6ca1\u6709<\/td><td>\u6ca1\u6709<\/td><td>\u662f<\/td><\/tr><tr><td><strong>\u6838\u7cd6\u4f53\u8d28\u91cf<\/strong><\/td><td>\u6ca1\u6709<\/td><td>\u6ca1\u6709<\/td><td>\u6ca1\u6709<\/td><td>JA\uff08miRNA \u8c03\u63a7\uff09<\/td><\/tr><tr><td><strong>Treg \u652f\u6301<\/strong><\/td><td>\u5f31<\/td><td>\u5f31<\/td><td>\u5f31\uff08\u672a\u963b\u65ad JAK3\uff09<\/td><td>STARK\uff08\u901a\u8fc7 PI3K\/AKT + \u6838\u7cd6\u4f53\uff09<\/td><\/tr><tr><td><strong>IL-10 \u589e\u52a0<\/strong><\/td><td>\u6700\u4f4e\u9650\u5ea6<\/td><td>\u6700\u4f4e\u9650\u5ea6<\/td><td>\u4f4e<\/td><td>STARK\uff08\u901a\u8fc7\u6838\u7cd6\u4f53 + Treg \u652f\u6301\uff09<\/td><\/tr><tr><td><strong>\u5f00\u59cb<\/strong><\/td><td>4-8 Wo<\/td><td>4-12 Wo<\/td><td>2-4 Wo<\/td><td>4-8 Wo\uff08\u4f30\u8ba1\u503c\uff09<\/td><\/tr><tr><td><strong>\u611f\u67d3\u98ce\u9669<\/strong><br><\/td><td>\u589e\u52a0<\/td><td>\u4e2d\u5ea6<\/td><td>\u4e2d\u5ea6<\/td><td>\u4f4e\uff08\u65e0\u514d\u75ab\u6291\u5236\uff01\uff09\u3002<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Dosierungsempfehlung_bei_ARLA_im_fortgeschrittenen_Stadium\"><\/span>Dosierungsempfehlung bei ARLA im fortgeschrittenen Stadium<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><strong>ARLA \u665a\u671f\uff0c\u591a\u5668\u5b98\u611f\u67d3<\/strong>&nbsp;\u5176\u4e25\u91cd\u7a0b\u5ea6\u548c\u7cfb\u7edf\u8d1f\u62c5\u4e0e\u6700\u4e25\u91cd\u7684\u764c\u75c7\u75c5\u4f8b\u76f8\u5f53\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6162\u6027\u591a\u5668\u5b98\u708e\u75c7<\/li>\n\n\n\n<li>\u81ea\u4f53\u514d\u75ab\u6210\u5206<\/li>\n\n\n\n<li>\u591a\u91cd\u81ea\u5faa\u73af\u53cd\u9988\u56de\u8def<\/li>\n\n\n\n<li>\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d<\/li>\n\n\n\n<li>\u6838\u7cd6\u4f53\u635f\u4f24<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Vorschlag_fur_ARLA-Dosierung\"><\/span>\u5173\u4e8e ARLA \u914d\u6599\u7684\u5efa\u8bae<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><strong>\u5efa\u8bae\uff1a50-60 \u514b\/\u5929<\/strong><br>\u5206\u4e3a 3 \u4efd\uff0c\u6bcf\u4efd\u76f8\u9694 8 \u5c0f\u65f6<br>\u4e0e\u6240\u6709\u5236\u5242\u4e00\u6837\uff0c\u6d3b\u6027\u6210\u5206\u7684\u6d53\u5ea6\u5bf9\u8fbe\u5230\u9884\u671f\u6548\u679c\u81f3\u5173\u91cd\u8981\u3002\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\uff0c\u6709\u6548\u6210\u5206\u6216\u591a\u6216\u5c11\u4f1a\u88ab\u4eba\u4f53\u5feb\u901f\u5206\u89e3\uff0c\u56e0\u6b64\u5fc5\u987b\u7cbe\u786e\u63a7\u5236\u6bcf\u6b21\u670d\u7528\u7684\u65f6\u95f4\u95f4\u9694\uff0c\u4ee5\u4fdd\u6301\u5168\u5929\u6709\u6548\u6210\u5206\u7684\u7a33\u5b9a\u6c34\u5e73\uff01<\/p>\n\n\n\n<p><strong>\u4e3a\u4ec0\u4e48\u662f 50 - 60 \u514b\/\u5929\uff0c\u800c\u4e0d\u662f\u5982 40 \u514b\/\u5929\uff1a<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>\u4e25\u91cd\u6027<\/strong>\u591a\u5668\u5b98\u53d7\u7d2f\u4e0e\u7530\u4e2d\u7814\u7a76\u4e2d\u7684 IV \u671f\u764c\u75c7\u76f8\u5bf9\u5e94<\/li>\n\n\n\n<li><strong>\u591a\u79cd\u4f5c\u7528\u673a\u5236<\/strong>\u5fc5\u987b\u540c\u65f6\u89e3\u51b3\u6240\u6709 4 \u4e2a\u673a\u5236\u7684\u95ee\u9898<\/li>\n\n\n\n<li><strong>\u5242\u91cf\u4f9d\u8d56\u6027<\/strong>\u7530\u4e2d\u663e\u793a\u51fa\u660e\u663e\u7684\u5242\u91cf\u4f9d\u8d56\u6027\uff0c\u4f46\u65e0\u6bd2\u6027<\/li>\n\n\n\n<li><strong>\u65f6\u95f4\u56e0\u7d20<\/strong>\u5242\u91cf\u8d8a\u5927\uff0c\u8d77\u6548\u8d8a\u5feb<\/li>\n<\/ol>\n\n\n\n<p><strong>\u7528\u836f\u65b9\u6848\uff08\u5efa\u8bae\uff09\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7b2c 1 \u9636\u6bb5\uff08\u7b2c 1-4 \u5468\uff09<\/strong><br>60 \u514b\/\u5929\uff08\u5206\u4e3a 3x20 \u514b\uff09<br>\u91cd\u70b9\uff1a\u6291\u5236 NF-\u03baB\uff0c\u5f00\u59cb JAK\/STAT \u8c03\u8282<br>\u6bcf\u6708\u8d39\u7528\uff08\u7ea6\uff09 568 \u6b27\u5143<\/li>\n\n\n\n<li><strong>\u7b2c\u4e8c\u9636\u6bb5\uff08\u7b2c 5-12 \u5468\uff09<\/strong><br>50 \u514b\/\u5929\uff083\u00d716-17 \u514b\uff09<br>\u91cd\u70b9\uff1a JAK\/STAT \u4f5c\u7528\u5b8c\u5168\u786e\u7acb\uff0cPI3K\/AKT \u6fc0\u6d3b<br>\u8d39\u7528\/\u6708\uff08\u7ea6\uff09 473,- \u6b27\u5143<\/li>\n\n\n\n<li><strong>\u7b2c 3 \u9636\u6bb5\uff08\u7b2c 4-6 \u4e2a\u6708\uff09<\/strong><br>40\u514b\/\u5929\uff083x13\u514b\uff09<br>\u4fdd\u62a4\u3001\u6838\u7cd6\u4f53\u4fee\u590d<br>\u6bcf\u6708\u8d39\u7528\uff08\u7ea6\uff09 379 \u6b27\u5143<\/li>\n\n\n\n<li><strong>\u957f\u671f\u4fdd\u5b58<\/strong><br>20-30 \u514b\/\u5929\uff083x 7 ... 3x 10 \u514b\uff09<br>\u8d39\u7528\/\u6708\uff08\u7ea6\uff09 189 ...284,- \u6b27\u5143<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Weitere_relevante_Beitrage_zum_Anwendungsbereich_des_Huaier-Pilzes\"><\/span>\u5173\u4e8e\u6000\u5c14\u83c7\u9002\u7528\u8303\u56f4\u7684\u5176\u4ed6\u76f8\u5173\u6761\u6b3e<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u57fa\u7840\u77e5\u8bc6\u548c\u764c\u75c7\u6cbb\u7597<\/strong> -&gt; <a href=\"https:\/\/csiag.eu\/zh\/%e6%b7%ae%e5%b0%94%e8%8f%87%e5%9c%a8%e7%99%8c%e7%97%87%e6%b2%bb%e7%96%97%e4%b8%ad%e7%9a%84%e5%ba%94%e7%94%a8\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/csiag.eu\/huaier-pilz-in-der-krebstherapie\/<\/a><\/li>\n\n\n\n<li><strong>\u6162\u6027\u75be\u75c5<\/strong> -&gt; <a href=\"https:\/\/csiag.eu\/zh\/%e6%b2%bb%e7%96%97%e6%85%a2%e6%80%a7%e7%96%be%e7%97%85%e7%9a%84%e6%b7%ae%e8%80%b3\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/csiag.eu\/huaier-pilz-bei-chronischen-erkrankungen\/<\/a><\/li>\n<\/ul>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>\u6240\u8c13\u7684\u201e\u4fbf\u5b9c\u201c\u7684\u534e\u5c14\u9897\u7c92\u4f9b\u5e94\u5546\u3002\u6240\u8c13\u7684\u201e\u6602\u8d35\u201c\u548c\u201e\u4fbf\u5b9c\u201c\u7684\u4ea7\u54c1\u4e4b\u95f4\u7684\u533a\u522b\u5728\u4e8e\uff0c\u6602\u8d35\u7684\u4ea7\u54c1\u662f\u4ece\u534e\u5c14\u8611\u83c7\u7684\u5b50\u5b9e\u4f53\u4e2d\u63d0\u53d6\u7684\uff0c\u800c\u4fbf\u5b9c\u7684\u4ea7\u54c1\u5219\u662f\u7531\u4f8b\u5982\u8c37\u7269\u4e0a\u7684\u83cc\u4e1d\u4f53\u5236\u6210\u7684\uff0c\u5176\u6d3b\u6027\u6210\u5206\u542b\u91cf\u6709\u65f6\u53ea\u6709\u5341\u5206\u4e4b\u4e00\uff0c\u5e76\u4e14\u5728\u56fa\u4f53\u53d1\u9175\u4e2d\u542b\u670990% \u672a\u6d88\u5316\u586b\u5145\u7269\u3002.<\/p>\n\n\n\n<p>\u7136\u800c\uff0c\u5728\u6db2\u4f53\u53d1\u9175\u4e2d\uff0c\u5373\u5728\u5bcc\u542b\u8425\u517b\u7684\u6db2\u4f53\u57f9\u517b\u57fa\u4e2d\u57f9\u517b\u83cc\u4e1d\u4f53\uff0c\u53c8\u542b\u6709\u4e00\u4e9b\u65e0\u6cd5\u4ece\u5b50\u5b9e\u4f53\u4e2d\u63d0\u53d6\u7684\u6d3b\u6027\u6210\u5206\u3002.<\/p>\n\n\n\n<p>\u201e\u5b50\u5b9e\u4f53\u201c\u662f\u6307\u4eba\u4eec\u89c6\u89c9\u4e0a\u80fd\u770b\u5230\u7684\u8611\u83c7\u90e8\u5206\uff0c\u201e\u83cc\u4e1d\u4f53\u201c\u662f\u6307\u8611\u83c7\u7684\u5185\u90e8\u3002.<\/p>\n<\/blockquote>","protected":false},"excerpt":{"rendered":"<p><span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">\u9605\u8bfb\u65f6\u95f4<\/span> <span class=\"rt-time\"> 18<\/span> <span class=\"rt-label rt-postfix\">\u5206\u949f<\/span><\/span>Borreliose wird durch Borrelia burgdorferi, einem spiralf\u00f6rmigen Bakterium, das die Lyme-Borreliose (auch Lyme-Krankheit genannt) verursacht. Er ist einer der wenigen Erreger, die wissenschaftlich derart faszinierend sind und gleichzeitig die schwierigsten bakteriellen Infektionen in Immunologie und Klinik darstellen: Die meisten Menschen mit Lyme-Arthritis erfahren Heilung nach Antibiotika-Therapie. Doch etwa 10% sprechen nicht auf diese Behandlung an&hellip;&nbsp;<a href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/01\/17\/borreliose-huaier-ansatz-fuer-arla-patienten-antibiotic-resistant-lyme-arthritis\/\" rel=\"bookmark\">\u9605\u8bfb\u66f4\u591a \u00bb<span class=\"screen-reader-text\">\u83b1\u59c6\u75c5--ARLA\uff08\u6297\u751f\u7d20\u8010\u836f\u6027\u83b1\u59c6\u5173\u8282\u708e\uff09\u60a3\u8005\u7684\u6000\u5c14\u7597\u6cd5<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[1078,354],"tags":[],"class_list":["post-12268","post","type-post","status-publish","format-standard","hentry","category-medizin","category-medizin-gesundheit"],"modified_by":"Achim Goerner","_links":{"self":[{"href":"https:\/\/csiag.eu\/zh\/wp-json\/wp\/v2\/posts\/12268","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csiag.eu\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csiag.eu\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csiag.eu\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csiag.eu\/zh\/wp-json\/wp\/v2\/comments?post=12268"}],"version-history":[{"count":2,"href":"https:\/\/csiag.eu\/zh\/wp-json\/wp\/v2\/posts\/12268\/revisions"}],"predecessor-version":[{"id":13417,"href":"https:\/\/csiag.eu\/zh\/wp-json\/wp\/v2\/posts\/12268\/revisions\/13417"}],"wp:attachment":[{"href":"https:\/\/csiag.eu\/zh\/wp-json\/wp\/v2\/media?parent=12268"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csiag.eu\/zh\/wp-json\/wp\/v2\/categories?post=12268"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csiag.eu\/zh\/wp-json\/wp\/v2\/tags?post=12268"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}