{"id":12718,"date":"2026-02-17T18:46:40","date_gmt":"2026-02-17T18:46:40","guid":{"rendered":"https:\/\/csiag.eu\/?p=12718"},"modified":"2026-02-17T20:56:03","modified_gmt":"2026-02-17T20:56:03","slug":"%e8%8e%ab%e6%a0%bc%e5%be%b7-%e8%8e%ab%e6%a0%bc%e6%8a%97%e4%bd%93%e7%9b%b8%e5%85%b3%e7%96%be%e7%97%85","status":"publish","type":"post","link":"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/","title":{"rendered":"MOGAD - MOG \u6297\u4f53\u76f8\u5173\u75be\u75c5"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_86 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u76ee\u5f55<\/p>\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Was_ist_MOGAD\" >\u4ec0\u4e48\u662f MOGAD\uff1f<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Was_geht_bei_MOGAD_schief\" >MOGAD \u51fa\u4e86\u4ec0\u4e48\u95ee\u9898\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Wo_im_Korper_passiert_das\" >\u8fd9\u79cd\u60c5\u51b5\u53d1\u751f\u5728\u8eab\u4f53\u7684\u54ea\u4e2a\u90e8\u4f4d\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Wie_verlauft_die_Erkrankung\" >\u75be\u75c5\u662f\u5982\u4f55\u53d1\u5c55\u7684\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Wie_haufig_ist_MOGAD\" >MOGAD \u6709\u591a\u5e38\u89c1\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Was_lost_MOGAD_aus\" >\u662f\u4ec0\u4e48\u5f15\u53d1\u4e86 MOGAD\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Wie_wird_MOGAD_behandelt\" >\u5982\u4f55\u6cbb\u7597 MOGAD\uff1f<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Wissenschaftliche_Einleitung_und_Definition\" >\u79d1\u5b66\u4ecb\u7ecd\u548c\u5b9a\u4e49<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Abgrenzung_von_MOGAD_NMOSD_und_MS\" >MOGAD\u3001NMOSD \u548c MS \u4e4b\u95f4\u7684\u533a\u522b<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#MOG-Protein_%E2%80%93_Struktur_und_physiologische_Funktion\" >MOG \u86cb\u767d--\u7ed3\u6784\u548c\u751f\u7406\u529f\u80fd<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Strukturdomanen\" >\u7ed3\u6784\u57df<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Physiologische_Funktionen\" >\u751f\u7406\u529f\u80fd<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Pathogenese_und_Immunpathologie\" >\u53d1\u75c5\u673a\u5236\u548c\u514d\u75ab\u75c5\u7406\u5b66<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Trigger_und_initiale_Aktivierung\" >\u89e6\u53d1\u548c\u521d\u59cb\u542f\u52a8<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#T-Zell-vermittelte_Pathogenese\" >T \u7ec6\u80de\u4ecb\u5bfc\u7684\u53d1\u75c5\u673a\u5236<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Phase_1_%E2%80%93_Periphere_Aktivierung\" >\u7b2c 1 \u9636\u6bb5--\u5916\u56f4\u6fc0\u6d3b<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Phase_2_%E2%80%93_BHS-Penetration\" >\u7b2c 2 \u9636\u6bb5 - BHS \u7684\u6e17\u900f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Phase_3_%E2%80%93_Perivaskulare_Reaktivierung\" >\u7b2c 3 \u9636\u6bb5--\u8840\u7ba1\u5468\u56f4\u518d\u6fc0\u6d3b<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#B-Zell-_und_Antikorper-vermittelte_Pathogenese\" >B \u7ec6\u80de\u548c\u6297\u4f53\u4ecb\u5bfc\u7684\u53d1\u75c5\u673a\u5236<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Molekulare_Signalwege_und_Effektormechanismen\" >\u5206\u5b50\u4fe1\u53f7\u901a\u8def\u548c\u6548\u5e94\u673a\u5236<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Signalweg_1_%E2%80%93_Klassischer_Komplementweg_CDC\" >\u4fe1\u53f7\u901a\u8def 1 - \u7ecf\u5178\u8865\u4f53\u9014\u5f84 (CDC)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Signalweg_2_%E2%80%93_Fc%CE%B3-Rezeptor-Weg_FcR-vermittelt\" >\u4fe1\u53f7\u901a\u8def 2 - Fc\u03b3 \u53d7\u4f53\u901a\u8def\uff08FcR \u4ecb\u5bfc\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Signalweg_3_%E2%80%93_IL-6JAK-STAT3-Weg\" >\u4fe1\u53f7\u901a\u8def 3 - IL-6\/JAK-STAT3 \u901a\u8def<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Signalweg_4_%E2%80%93_MAPK-_und_AKT-Signalwege_B-Zellen\" >\u4fe1\u53f7\u901a\u8def 4 - MAPK \u548c AKT \u4fe1\u53f7\u901a\u8def\uff08B \u7ec6\u80de\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Signalweg_5_%E2%80%93_Th17-Zytokin-Netzwerk_im_ZNS\" >\u4fe1\u53f7\u901a\u8def 5--\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u4e2d\u7684 Th17 \u7ec6\u80de\u56e0\u5b50\u7f51\u7edc<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-26\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Signalwege_%E2%80%93_Ubersicht\" >\u4fe1\u53f7\u901a\u8def - \u6982\u8ff0<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-27\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Relevante_Rezeptoren_und_Zielmolekule\" >\u76f8\u5173\u53d7\u4f53\u548c\u76ee\u6807\u5206\u5b50<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-28\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#MOG_selbst_als_Zielstruktur_kein_klassischer_Rezeptor\" >MOG \u672c\u8eab\u662f\u4e00\u79cd\u76ee\u6807\u7ed3\u6784\uff08\u800c\u4e0d\u662f\u5178\u578b\u7684\u53d7\u4f53\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-29\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Fc%CE%B3-Rezeptoren_Fc%CE%B3R\" >Fc\u03b3 \u53d7\u4f53\uff08Fc\u03b3R\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-30\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Neonataler_Fc-Rezeptor_FcRn\" >\u65b0\u751f\u513f Fc \u53d7\u4f53\uff08FcRn\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-31\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#IL-6-Rezeptor_IL-6R%CE%B1_gp130\" >IL-6 \u53d7\u4f53\uff08IL-6R\u03b1 \/ gp130\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-32\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#T-Zell-Rezeptor_TCR_und_Kostimulationsmolekule\" >T \u7ec6\u80de\u53d7\u4f53 (TCR) \u548c\u6210\u672c\u523a\u6fc0\u5206\u5b50<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-33\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Komplementrezeptoren\" >\u8865\u4f53\u53d7\u4f53<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-34\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Histopathologie_und_ZNS-Lasionsmuster\" >\u7ec4\u7ec7\u75c5\u7406\u5b66\u548c\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75c5\u53d8\u6a21\u5f0f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-35\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Klinische_Manifestationen_und_Phanotypen\" >\u4e34\u5e8a\u8868\u73b0\u548c\u8868\u578b<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-36\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Diagnostik\" >\u8bca\u65ad<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-37\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Therapeutische_Strategien\" >\u6cbb\u7597\u7b56\u7565<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-38\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Akuttherapie_Schubbehandlung\" >\u6025\u6027\u6cbb\u7597\uff08\u590d\u53d1\u6cbb\u7597\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-39\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Prophylaktische_Langzeittherapie\" >\u9884\u9632\u6027\u957f\u671f\u6cbb\u7597<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-40\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Klinische_Studien_%E2%80%93_2024%E2%80%932026\" >\u4e34\u5e8a\u7814\u7a76 - 2024-2026<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-41\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Neue_und_zukunftige_Therapiekonzepte\" >\u65b0\u7684\u548c\u672a\u6765\u7684\u6cbb\u7597\u7406\u5ff5<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-42\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#BTK-Inhibitoren_Bruton-Tyrosin-Kinase\" >BTK \u6291\u5236\u5242\uff08\u5e03\u9c81\u987f\u916a\u6c28\u9178\u6fc0\u9176\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-43\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Toleranzinduktion_MOG-Tolerisierung\" >\u8010\u53d7\u8bf1\u5bfc\uff08MOG \u8010\u53d7\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-44\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Komplementinhibitoren\" >\u8865\u4f53\u6291\u5236\u5242<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-45\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Anti-Neonatal-Fc-Rezeptor-Strategien\" >\u6297\u65b0\u751f\u513f Fc \u53d7\u4f53\u7b56\u7565<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-46\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Autologe_hamatopoetische_Stammzelltransplantation_aHSCT\" >\u81ea\u4f53\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\uff08aHSCT\uff09<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-47\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Biomarker_und_Verlaufsmonitoring\" >\u751f\u7269\u6807\u5fd7\u7269\u548c\u540e\u7eed\u76d1\u6d4b<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-48\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Prognose_und_Besonderheiten\" >\u9884\u6d4b\u548c\u7279\u5199<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-49\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Zusammenfassung_und_Ausblick\" >\u603b\u7ed3\u4e0e\u5c55\u671b<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-50\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Atherischer_Ole_%E2%80%93_Wirkstoffe_nach_Signalwegen_geordnet\" >\u7cbe\u6cb9--\u6839\u636e\u4fe1\u53f7\u901a\u8def\u5206\u7c7b\u7684\u6d3b\u6027\u6210\u5206<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-51\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Weihrauch_Boswellia_serrata_%E2%80%93_AKBA_und_Incensolacetat\" >\u4e73\u9999\uff08Boswellia serrata\uff09--AKBA \u548c\u918b\u9178incensol<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-52\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Therapeutisch_relevante_AKBA-Zieldosen\" >\u4e0e\u6cbb\u7597\u76f8\u5173\u7684 AKBA \u76ee\u6807\u5242\u91cf<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-53\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Umrechnung_auf_375_mg_AKBA_jeKapsel\" >\u6362\u7b97\u6210\u6bcf\u7c92 37.5 \u6beb\u514b AKBA<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-54\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Wichtige_Einnahmehinweise\" >\u91cd\u8981\u63a5\u6536\u8bf4\u660e<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-55\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Schwarzer_Pfeffer_oral\" >\u9ed1\u80e1\u6912\uff08\u53e3\u670d\uff09<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-56\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Schwarzer_Pfeffer_Inhalation\" >\u9ed1\u80e1\u6912\uff08\u5438\u5165\uff09<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-57\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Copaiba-Ol_oral_%E2%80%93_NUR_doTERRA\" >Copaiba \u6cb9\uff08\u53e3\u670d\uff09 - ONLY doTERRA<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-58\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#MOGAD-spezifische_Dosierungstabelle_doTERRA_Copaiba_525_BCP\" >MOGAD \u4e13\u7528\u5242\u91cf\u8868\uff08doTERRA Copaiba 52.5 % BCP\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-59\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#MOGAD-Phasen-adaptierte_Dosierung\" >MOGAD \u9636\u6bb5\u6027\u8c03\u6574\u5242\u91cf<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-60\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Phase_1_Akuter_Schub_erste_2%E2%80%934_Wochen\" >\u7b2c 1 \u9636\u6bb5\uff1a\u6025\u6027\u53d1\u4f5c\uff08\u6700\u521d 2-4 \u5468\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-61\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Phase_2_Schubremission_Erhaltung_langfristig\" >\u7b2c\u4e8c\u9636\u6bb5\uff1a\u590d\u53d1\u7f13\u89e3\/\u7ef4\u6301\uff08\u957f\u671f\uff09<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-62\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Phase_3_Monophasischer_Verlauf_Titer_fallend\" >\u7b2c 3 \u9636\u6bb5\uff1a\u5355\u76f8\u7597\u7a0b\uff08\u6ef4\u5ea6\u4e0b\u964d\uff09<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-63\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Quellen\" >\u8d44\u6599\u6765\u6e90<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-64\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Copaiba-Ol_Inhalation\" >\u79d1\u5e15\u5df4\u6cb9\uff08\u5438\u5165\uff09<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-65\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Zieldosen_und_benotigte_Tropfenzahl\" >\u76ee\u6807\u5242\u91cf\u548c\u6240\u9700\u6ef4\u6570<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-66\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Synergistische_MOGAD-Strategie_Multi-Target\" >\u534f\u540c MOGAD \u6218\u7565\uff08\u591a\u76ee\u6807\uff09<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-67\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Wichtige_MOGAD-spezifische_Hinweise\" >\u9488\u5bf9 MOGAD \u7684\u91cd\u8981\u4fe1\u606f<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-68\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#%CE%B1-Asaron_Kalmus-Ol_Acorus_calamus_%E2%80%93_direkt_oligodendrozytenprotektiv\" >\u03b1-Asarone \uff08\u83d6\u84b2\u6cb9\uff0c\u77f3\u83d6\u84b2\uff09--\u76f4\u63a5\u4fdd\u62a4\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-69\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Geraniumol_Pelargonium_graveolens_%E2%80%93_Neuroinflammation_und_NO\" >\u5929\u7afa\u8475\u6cb9\uff08Pelargonium graveolens\uff09--\u795e\u7ecf\u708e\u75c7\u548c NO<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-70\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Teebaum-Ol_Melaleuca_alternifolia_%E2%80%93_Mikroglia-Modulation\" >\u8336\u6811\u6cb9\uff08\u4e92\u53f6\u767d\u5343\u5c42\uff09--\u8c03\u8282\u5c0f\u795e\u7ecf\u80f6\u8d28\u7ec6\u80de<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-71\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Wirkstoffubersicht_nach_MOGAD-Signalwegen\" >\u6839\u636e MOGAD \u4fe1\u53f7\u901a\u8def\u5212\u5206\u7684\u6d3b\u6027\u7269\u8d28\u6982\u89c8<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-72\" href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/#Quellen_und_weiterfuhrende_Literatur\" >\u8d44\u6599\u6765\u6e90\u548c\u8fdb\u4e00\u6b65\u9605\u8bfb<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">\u9605\u8bfb\u65f6\u95f4<\/span> <span class=\"rt-time\"> 17<\/span> <span class=\"rt-label rt-postfix\">\u5206\u949f<\/span><\/span>\n<p class=\"wp-block-paragraph\"><em>\u9ad3\u9798\u5be1\u7a81\u80f6\u8d28\u7ec6\u80de\u86cb\u767d\u6297\u4f53\u76f8\u5173\u75be\u75c5<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Was_ist_MOGAD\"><\/span>\u4ec0\u4e48\u662f MOGAD\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u6bcf\u4e2a\u4eba\u90fd\u77e5\u9053\u7535\u7f06\uff1a\u7535\u7f06\u4e0a\u6709\u7edd\u7f18\u5c42\uff0c\u5c06\u7535\u7f06\u675f\u4e2d\u7684\u5404\u4e2a\u5bfc\u4f53\u76f8\u4e92\u9694\u5f00\uff0c\u4f7f\u5176\u4e2d\u7684\u4fe1\u53f7\u4e0d\u4f1a\u76f8\u4e92\u5e72\u6270\uff0c\u5e76\u80fd\u4e0d\u5931\u771f\u7684\u4ece A \u5904\u4f20\u8f93\u5230 B \u5904\u3002.<br>\u810a\u9ad3\u4e2d\u5305\u542b\u4e00\u6574\u4e32\u8fd9\u6837\u7684\u7535\u7f06\u675f\u3002\u5b83\u4eec\u5c06\u795e\u7ecf\u4fe1\u53f7\u4ece\u5927\u8111\u4f20\u5bfc\u5230\u8eab\u4f53\u7684\u5404\u4e2a\u5668\u5b98\u3001\u808c\u8089\u548c\u7ec4\u7ec7\u7b49\u3002\u7535\u7f06\u7684\u7edd\u7f18\u5c42\u7531\u5851\u6599\u3001\u7eba\u7ec7\u54c1\u6216\u7279\u6b8a\u6750\u6599\u5236\u6210\uff0c\u800c\u810a\u9ad3\u7684\u7edd\u7f18\u5c42\u5219\u7531\u7279\u6b8a\u6750\u6599\u5236\u6210\u3002 <strong>\u9ad3\u9798\u5c42<\/strong>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Was_geht_bei_MOGAD_schief\"><\/span>MOGAD \u51fa\u4e86\u4ec0\u4e48\u95ee\u9898\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728 MOGAD \u7684\u60c5\u51b5\u4e0b\uff0c\u4eba\u4f53\u81ea\u8eab\u7684\u514d\u75ab\u7cfb\u7edf\u72af\u4e86\u4e00\u4e2a\u4e25\u91cd\u7684\u9519\u8bef\uff1a\u5b83\u9519\u8bef\u5730\u4ea7\u751f\u4e86 <strong>\u9488\u5bf9\u7edd\u7f18\u5c42\u5916\u90e8\u7279\u5b9a\u86cb\u767d\u8d28\u7684\u6297\u4f53<\/strong>, \u6240\u8c13\u3002. <strong>MOG<\/strong>-\u86cb\u767d\u8d28\u3002\u6297\u4f53\u5b9e\u9645\u4e0a\u662f\u4eba\u4f53\u7684\u536b\u58eb\uff0c\u80fd\u591f\u8bc6\u522b\u3001\u6807\u8bb0\u5e76\u6d88\u706d\u75c5\u6bd2\u548c\u7ec6\u83cc\u7b49\u75c5\u539f\u4f53\u3002\u7136\u800c\uff0c\u5728 MOGAD \u4e2d\uff0c\u5b83\u4eec\u5374\u9519\u8bef\u5730\u9488\u5bf9\u4eba\u4f53\u81ea\u8eab\u7684\u5065\u5eb7\u7ec4\u7ec7\uff0c\u5373\u4eba\u4f53\u81ea\u8eab\u795e\u7ecf\u7ea4\u7ef4\u7684\u7edd\u7f18\u5c42\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e0e\u7535\u7f06\u76f8\u6bd4\uff0c\u8fd9\u5c31\u597d\u6bd4\u522e\u4f24\u3001\u78e8\u635f\u6216\u8150\u8680\u7edd\u7f18\u5c42\uff0c\u5bfc\u81f4\u7edd\u7f18\u5c42\u7a7f\u5b54\uff0c\u7535\u4fe1\u53f7\u4e0d\u518d\u80fd\u5e72\u51c0\u5229\u843d\u5730\u5230\u8fbe\u76ee\u7684\u5730\uff0c\u751a\u81f3\u6839\u672c\u65e0\u6cd5\u5230\u8fbe\u76ee\u7684\u5730\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wo_im_Korper_passiert_das\"><\/span>\u8fd9\u79cd\u60c5\u51b5\u53d1\u751f\u5728\u8eab\u4f53\u7684\u54ea\u4e2a\u90e8\u4f4d\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">MOGAD \u4ec5\u6d89\u53ca <strong>\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf<\/strong>, \u5373\u5927\u8111\u3001\u810a\u9ad3\u548c\u89c6\u795e\u7ecf\u3002\u6839\u636e\u53d7\u5f71\u54cd\u7684\u90e8\u4f4d\u4e0d\u540c\uff0c\u4f1a\u51fa\u73b0\u4e0d\u540c\u7684\u75c7\u72b6\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u89c6\u795e\u7ecf<\/strong> - \u89c6\u529b\u7a81\u7136\u4e27\u5931\u3001\u89c6\u529b\u6a21\u7cca\u3001\u773c\u75db\uff08\u901a\u5e38\u4ec5\u5355\u773c\u75bc\u75db\uff0c\u6709\u65f6\u53cc\u773c\u540c\u65f6\u75bc\u75db--\u8fd9\u79cd\u60c5\u51b5\u5728\u83ab\u5409\u5fb7\u6c0f\u75c5\u4e2d\u6bd4\u5728\u5176\u4ed6\u7c7b\u4f3c\u75be\u75c5\u4e2d\u66f4\u4e3a\u5e38\u89c1\uff09<\/li>\n\n\n\n<li><strong>\u810a\u9ad3<\/strong> - \u9ebb\u75f9\u3001\u9ebb\u6728\u3001\u6392\u5c3f\u56f0\u96be\u7684\u75c7\u72b6<\/li>\n\n\n\n<li><strong>\u5927\u8111 \uff1a<\/strong> \u610f\u8bc6\u6a21\u7cca\u3001\u766b\u75eb\u53d1\u4f5c\u3001\u534f\u8c03\u969c\u788d<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wie_verlauft_die_Erkrankung\"><\/span>\u75be\u75c5\u662f\u5982\u4f55\u53d1\u5c55\u7684\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">MOGAD \u901a\u5e38\u4ee5\u4e0b\u5217\u65b9\u5f0f\u8fdb\u884c <strong>\u63a8\u52a8<\/strong>. .\u708e\u75c7\u6d3b\u8dc3\u548c\u51fa\u73b0\u75c7\u72b6\u7684\u9636\u6bb5\u662f\u95f4\u6b47\u6027\u7684\uff0c\u800c\u4e2d\u95f4\u7684\u9636\u6bb5\u5219\u8f83\u4e3a\u5e73\u9759\u3002.<br>\u53d1\u4f5c\u540e\uff0c\u8bb8\u591a\u60a3\u8005\u7684\u6062\u590d\u60c5\u51b5\u51fa\u5947\u5730\u597d\uff0c\u4f8b\u5982\u6bd4\u591a\u53d1\u6027\u786c\u5316\u75c7\u60a3\u8005\u6062\u590d\u5f97\u66f4\u597d\u3002\u8fd9\u662f\u56e0\u4e3a\u795e\u7ecf\u7ea4\u7ef4\u672c\u8eab\u53d7\u5230\u6c38\u4e45\u6027\u635f\u4f24\u7684\u53ef\u80fd\u6027\u5f80\u5f80\u4f4e\u4e8e\u7edd\u7f18\u5c42\uff0c\u7edd\u7f18\u5c42\u53ef\u4ee5\u90e8\u5206\u518d\u751f\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7ea6\u6709\u4e00\u534a\u7684\u60a3\u8005\u4e00\u751f\u4e2d\u53ea\u4f1a\u53d1\u4f5c\u4e00\u6b21\u3002\u53e6\u4e00\u534a\u60a3\u8005\u5219\u4f1a\u53cd\u590d\u53d1\u4f5c\uff0c\u5982\u679c\u4e0d\u53ca\u65f6\u6cbb\u7597\uff0c\u53ef\u80fd\u4f1a\u5bfc\u81f4\u6c38\u4e45\u6027\u635f\u4f24\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wie_haufig_ist_MOGAD\"><\/span>MOGAD \u6709\u591a\u5e38\u89c1\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">MOGAD \u5f88\u7f55\u89c1\uff0c\u4f30\u8ba1\u53ea\u6709 <strong>\u6bcf 10 \u4e07\u4eba\u4e2d\u6709 1-2 \u4eba<\/strong> \u60a3\u75c5\u3002\u4e0e\u8bb8\u591a\u5176\u4ed6\u795e\u7ecf\u7cfb\u7edf\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u4e0d\u540c\u7684\u662f\uff0c\u8fd9\u79cd\u75be\u75c5\u5bf9\u5973\u6027\u548c\u7537\u6027\u7684\u5f71\u54cd\u5927\u81f4\u76f8\u540c\u3002\u513f\u7ae5\u4e5f\u53ef\u80fd\u60a3\u75c5\uff0c\u901a\u5e38\u8868\u73b0\u4e3a\u5927\u8111\u5e7f\u6cdb\u53d1\u708e\uff0c\u4f34\u6709\u610f\u8bc6\u6a21\u7cca\u548c\u53d1\u70e7\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Was_lost_MOGAD_aus\"><\/span>\u662f\u4ec0\u4e48\u5f15\u53d1\u4e86 MOGAD\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u7b2c\u4e00\u6b21\u53d1\u75c5\u540e\u5f80\u5f80\u4f1a\u51fa\u73b0 <strong>\u611f\u67d3<\/strong> \u524d\u65b9\u3002\u4eba\u4f53\u5728\u5bf9\u6297\u75c5\u539f\u4f53\u65f6\uff0c\u4f1a\u9519\u8bef\u5730\u5c06\u4eba\u4f53\u81ea\u8eab\u7684\u7ed3\u6784\u4e0e\u654c\u4eba\u6df7\u4e3a\u4e00\u8c08\u3002\u53ef\u4ee5\u8bf4\uff0c\u514d\u75ab\u7cfb\u7edf\u5b66\u4f1a\u4e86\u653b\u51fb\u9519\u8bef\u7684\u76ee\u6807\uff0c\u5e76\u4e14\u4ece\u672a\u505c\u6b62\u8fc7\u3002\u786e\u5207\u7684\u539f\u56e0\u5c1a\u672a\u5b8c\u5168\u660e\u4e86\u3002. <\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wie_wird_MOGAD_behandelt\"><\/span>\u5982\u4f55\u6cbb\u7597 MOGAD\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u76ee\u524d\u8fd8\u6ca1\u6709\u4e13\u95e8\u6388\u6743\u6cbb\u7597 MOGAD \u7684\u836f\u7269\u3002\u4e00\u79cd <strong>\u6025\u6027\u53d1\u4f5c<\/strong> \u4f7f\u7528\u5927\u5242\u91cf\u7684 <strong>\u53ef\u7684\u677e\u8f93\u6db2<\/strong>, \u8fd9\u80fd\u8fc5\u901f\u6291\u5236\u708e\u75c7\u3002\u5982\u679c\u8fd9\u8fd8\u4e0d\u591f <strong>\u8840\u6db2\u6e05\u6d17<\/strong> (<em>\u8840\u6d46\u7f6e\u6362\u672f<\/em>) \u53ef\u76f4\u63a5\u4ece\u8840\u6db2\u4e2d\u6e05\u9664\u6709\u5bb3\u6297\u4f53\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u81f4 <strong>\u9632\u6b62\u518d\u6b21\u590d\u53d1<\/strong> \u6709\u591a\u79cd\u836f\u7269\u53ef\u7528\u4e8e\u9547\u9759\u514d\u75ab\u7cfb\u7edf\uff0c\u4f8b\u5982\u4f7f\u7528\u51cf\u5c11\u6297\u4f53\u751f\u6210\u7ec6\u80de\u7684\u7269\u8d28\u3002\u76ee\u524d\uff0c\u51e0\u79cd\u66f4\u5177\u9488\u5bf9\u6027\u7684\u65b0\u836f\u6b63\u5728\u63a5\u53d7\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5e76\u6709\u53ef\u80fd\u5728\u672a\u6765\u51e0\u5e74\u5185\u83b7\u5f97\u6279\u51c6\u3002.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wissenschaftliche_Einleitung_und_Definition\"><\/span>\u79d1\u5b66\u4ecb\u7ecd\u548c\u5b9a\u4e49<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">\"(\u300a\u4e16\u754c\u4eba\u6743\u5ba3\u8a00\u300b) <strong>MOG \u6297\u4f53\u76f8\u5173\u75be\u75c5\uff08MOGAD\uff09<\/strong> \u82f1\u8bed\uff1a <em>\u9ad3\u9798\u5be1\u7a81\u80f6\u8d28\u7ec6\u80de\u86cb\u767d\u6297\u4f53\u76f8\u5173\u75be\u75c5<\/em> \u662f\u4e00\u79cd\u7f55\u89c1\u7684\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff08CNS\uff09\u708e\u75c7\u6027\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u81ea 2018 \u5e74\u8d77\u88ab\u8ba4\u5b9a\u4e3a\u5177\u6709\u72ec\u7acb\u8bca\u65ad\u6807\u51c6\u7684\u72ec\u7acb\u5b9e\u4f53\u3002\u5b83\u4ee5\u524d\u88ab\u8ba4\u4e3a\u662f\u591a\u53d1\u6027\u786c\u5316\u75c7\uff08MS\uff09\u6216\u795e\u7ecf\u810a\u9ad3\u708e\u89c6\u795e\u7ecf\u9891\u8c31\u969c\u788d\uff08NMOSD\uff09\u7684\u4e00\u79cd\u53d8\u4f53\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd9\u79cd\u75be\u75c5\u7684\u6838\u5fc3\u8981\u7d20\u662f\u5728\u75c5\u7406\u4e0a\u4ea7\u751f\u9488\u5bf9\u4ee5\u4e0b\u5668\u5b98\u7684\u81ea\u8eab\u6297\u4f53\uff08IgG\uff09 <strong>\u9ad3\u9798\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u7cd6\u86cb\u767d\uff08MOG\uff09<\/strong>, \u662f\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u4e2d\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u9ad3\u9798\u6700\u5916\u5c42\u7684\u4e00\u79cd\u8de8\u819c\u86cb\u767d\u3002\u8fd9\u4e9b\u6297\u4f53\u4f1a\u7834\u574f\u9ad3\u9798\uff0c\u5bfc\u81f4\u7279\u5f81\u6027\u7684\u5468\u56f4\u8131\u9ad3\u9798\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u4e34\u5e8a\u4e0a\uff0cMOGAD \u4e3b\u8981\u8868\u73b0\u4e3a\u89c6\u795e\u7ecf\u708e\u3001\u6a2a\u8d2f\u6027\u810a\u9ad3\u708e\u548c\u6025\u6027\u64ad\u6563\u6027\u8111\u810a\u9ad3\u708e\uff08ADEM\uff09\u3002\u8fd9\u79cd\u75be\u75c5\u901a\u5e38\u4f1a\u590d\u53d1\uff0c\u5f71\u54cd\u89c6\u795e\u7ecf\u3001\u810a\u9ad3\uff0c\u66f4\u7f55\u89c1\u7684\u60c5\u51b5\u662f\u5f71\u54cd\u5927\u8111\u3002\u53d1\u75c5\u5e74\u9f84\u7684\u4e2d\u4f4d\u6570\u5728 30 \u81f3 35 \u5c81\u4e4b\u95f4\uff1b\u4e0e NMOSD \u4e0d\u540c\u7684\u662f\uff0c\u5973\u6027\u548c\u7537\u6027\u7684\u53d1\u75c5\u7387\u51e0\u4e4e\u76f8\u540c\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Abgrenzung_von_MOGAD_NMOSD_und_MS\"><\/span>MOGAD\u3001NMOSD \u548c MS \u4e4b\u95f4\u7684\u533a\u522b<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><td><strong>\u7279\u70b9<\/strong><\/td><td><strong>MOGAD<\/strong><\/td><td><strong>AQP4+ NMOSD<\/strong><\/td><td><strong>\u591a\u53d1\u6027\u786c\u5316\u75c7<\/strong><\/td><\/tr><\/thead><tbody><tr><td>\u76ee\u6807\u6297\u539f<\/td><td>MOG\uff08\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\uff09<\/td><td>\u6c34\u84b8\u6c14\u7d20-4\uff08\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\uff09<\/td><td>\u65e0\u7279\u5f02\u6027\u81ea\u8eab\u6297\u4f53<\/td><\/tr><tr><td>\u6297\u4f53\u540c\u578b<\/td><td>IgG1\uff08\u524d\uff09<\/td><td>IgG1\uff08\u524d\uff09<\/td><td>\u5be1\u514b\u9686 IgG\uff08CSF\uff09<\/td><\/tr><tr><td>\u539f\u53d1\u6027\u7ec6\u80de\u635f\u4f24<\/td><td>\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\/\u9ad3\u9798<\/td><td>\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\uff08\u539f\u751f\uff09<\/td><td>\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de<\/td><\/tr><tr><td>\u7ec4\u7ec7\u5b66<\/td><td>\u5468\u56f4\u8131\u9ad3\u9798\uff0cCD4+<\/td><td>\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u75c5\u53d8\u3001\u7c92\u7ec6\u80de<\/td><td>\u8f74\u5468\u6591\u5757<\/td><\/tr><tr><td>\u6027\u522b\uff08\u7537\uff1a\u5973\uff09<\/td><td>~1:1<\/td><td>~9:1<\/td><td>~3:1<\/td><\/tr><tr><td>\u8865\u4f53\u6fc0\u6d3b<\/td><td>\u4e2d\u5ea6\uff08\u5c0f\u4e8e MAC\uff09<\/td><td>\u5f3a\uff08MAC \u7f16\u961f\uff09<\/td><td>\u4f4e<\/td><\/tr><tr><td>\u8111\u810a\u6db2\u4e2d\u7684 OKB<\/td><td>\u7f55\u89c1\uff08&lt;10%\uff09<\/td><td>\u5076\u5c14<\/td><td>\u9891\u7e41 (&gt;90%)<\/td><\/tr><tr><td>\u8bfe\u7a0b<\/td><td>\u590d\u53d1\uff1b\u901a\u5e38\u6062\u590d\u826f\u597d<\/td><td>\u523a\u72b6\uff1b\u7d2f\u79ef\u6b8b\u75be<\/td><td>\u901a\u5e38\u6709\u4eb2\u548c\u529b<\/td><\/tr><tr><td>\u6388\u6743\u7597\u6cd5<\/td><td>\u65e0\uff08\u622a\u81f3 2026 \u5e74\uff09<\/td><td>Eculizumab\u3001ublituximab\u3001satralizumab<\/td><td>\u8bb8\u591a DMT<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h1 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"MOG-Protein_%E2%80%93_Struktur_und_physiologische_Funktion\"><\/span>MOG \u86cb\u767d--\u7ed3\u6784\u548c\u751f\u7406\u529f\u80fd<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">MOG\uff08\u9ad3\u9798\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u7cd6\u86cb\u767d\uff09\u662f\u4e00\u79cd <strong>I \u578b\u8de8\u819c\u86cb\u767d<\/strong> \u5168\u957f 218 \u4e2a\u6c28\u57fa\u9178\uff0c\u53ea\u5728\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u4e2d\u8868\u8fbe\u3002\u5b83\u662f\u514d\u75ab\u7403\u86cb\u767d\u8d85\u5bb6\u65cf\u7684\u6210\u5458\uff0c\u5728\u9ad3\u9798\u86cb\u767d\u603b\u91cf\u4e2d\u6240\u5360\u6bd4\u4f8b\u7ea6\u4e3a 0.01-0.05 %\uff0c\u662f\u9ad3\u9798\u4e2d\u6570\u91cf\u5f88\u5c11\u4f46\u5728\u514d\u75ab\u5b66\u4e0a\u5177\u6709\u9ad8\u5ea6\u76f8\u5173\u6027\u7684\u6210\u5206\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Strukturdomanen\"><\/span>\u7ed3\u6784\u57df<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7ec6\u80de\u5916 Ig-V \u6837\u7ed3\u6784\u57df\uff08AS 1-120\uff09\uff1a\u5355\u66b4\u9732\u7ed3\u6784\u57df\uff0c\u514d\u75ab\u539f\u6027\u9ad8\uff1b\u5305\u542b\u5173\u952e\u7684 CC'\u73af\u533a\uff08Pro42\u3001His103\u3001Ser104\uff09\uff0c\u662f MOG-IgG \u7684\u4e3b\u8981\u8868\u4f4d\u7ed3\u5408\u4f4d\u70b9<\/li>\n\n\n\n<li>\u5355\u901a\u9053\u8de8\u819c\u87ba\u65cb\uff1a\u5c06\u86cb\u767d\u8d28\u951a\u5b9a\u5728\u9ad3\u9798\u819c\u4e0a<\/li>\n\n\n\n<li>\u7ec6\u80de\u8d28 C \u7aef\u77ed\u7ed3\u6784\u57df\uff1a\u53ef\u80fd\u4e0e\u7ec6\u80de\u9aa8\u67b6\u76f8\u4e92\u4f5c\u7528<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Physiologische_Funktionen\"><\/span>\u751f\u7406\u529f\u80fd<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7c98\u9644\u5206\u5b50\uff1a\u4ecb\u5bfc\u9ad3\u9798\u7ed3\u6784\u7684\u5b8c\u6574\u6027\uff0c\u53ef\u80fd\u662f\u901a\u8fc7\u538b\u5b9e\u9ad3\u9798\u7247\u5c42<\/li>\n\n\n\n<li>\u4e0e\u8865\u4f53\u7cfb\u7edf C1q \u7684\u76f8\u4e92\u4f5c\u7528\uff08\u751f\u7406\u5b66\uff09<\/li>\n\n\n\n<li>\u4e0e\u795e\u7ecf\u751f\u957f\u56e0\u5b50\uff08NGF\uff09\u7684\u76f8\u4e92\u4f5c\u7528<\/li>\n\n\n\n<li>\u98ce\u75b9\u75c5\u6bd2\u53d7\u4f53\uff08\u4e0e\u611f\u67d3\u540e ADEM \u4e34\u5e8a\u76f8\u5173\uff09<\/li>\n\n\n\n<li>\u7a33\u5b9a\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u4e2d\u7684\u5fae\u7ba1<\/li>\n\n\n\n<li>\u8868\u8fbe\uff1a\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u5206\u5316\u540e\u671f\uff1b\u4ec5\u5728\u6700\u521d\u7684\u9ad3\u9798\u5316\u4e4b\u540e<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">MOG-IgG \u81ea\u8eab\u6297\u4f53\u4e3b\u8981\u8bc6\u522b <strong>\u6784\u8c61\u8868\u4f4d<\/strong> \u7684\u7ec6\u80de\u5916\u7ed3\u6784\u57df\u3002\u7531\u4e8e MOG \u66b4\u9732\u5728\u9ad3\u9798\u7684\u6700\u5916\u5c42\uff0c\u56e0\u6b64\u53ef\u76f4\u63a5\u63a5\u89e6\u5230\u5faa\u73af\u6297\u4f53\u548c\u514d\u75ab\u590d\u5408\u7269\uff0c\u8fd9\u662f\u4e0e\u7ec6\u80de\u5185\u6297\u539f\u7684\u4e00\u4e2a\u51b3\u5b9a\u6027\u533a\u522b\u3002.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Pathogenese_und_Immunpathologie\"><\/span>\u53d1\u75c5\u673a\u5236\u548c\u514d\u75ab\u75c5\u7406\u5b66<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">MOGAD \u7684\u53d1\u75c5\u673a\u5236\u662f\u4e00\u4e2a\u591a\u6b65\u9aa4\u8fc7\u7a0b\uff0c\u6d89\u53ca\u5916\u5468\u514d\u75ab\u6fc0\u6d3b\u3001\u8de8\u8840\u8111\u5c4f\u969c\uff08BBB\uff09\u8fc1\u79fb\u548c\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u5c40\u90e8\u6548\u5e94\u673a\u5236\u3002\u5355\u9760 T \u7ec6\u80de\u6216 B \u7ec6\u80de\u90fd\u4e0d\u8db3\u4ee5\u81f4\u75c5\uff0c\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u7684\u4e24\u4e2a\u81c2\u8180\u534f\u540c\u4f5c\u7528\u624d\u662f\u81f4\u75c5\u539f\u56e0\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Trigger_und_initiale_Aktivierung\"><\/span>\u89e6\u53d1\u548c\u521d\u59cb\u542f\u52a8<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e3b\u8981\u7684\u521d\u59cb\u89e6\u53d1\u5668\u6709 <strong>\u611f\u67d3<\/strong> \u8ba8\u8bba\uff1a\u636e\u8bb0\u5f55\uff0c37-70 % \u7684 MOGAD \u60a3\u8005\u4f1a\u51fa\u73b0\u611f\u67d3\u524d\u9a71\u75c7\u72b6\uff08\u6bd4 15-35 % \u7684 NMOSD \u66f4\u5e38\u89c1\uff09\u3002\u5176\u673a\u5236\u5305\u62ec<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5206\u5b50\u6a21\u62df--\u75c5\u539f\u4f53\u8868\u4f4d\u5728\u7ed3\u6784\u4e0a\u4e0e MOG \u7684 CC'\u73af\u533a\u76f8\u4f3c\uff0c\u5982 SARS-CoV-2 \u5e8f\u5217\u6216\u98ce\u75b9\u75c5\u6bd2<\/li>\n\n\n\n<li>\u65c1\u89c2\u8005\u6fc0\u6d3b--\u975e\u7279\u5f02\u6027\u708e\u75c7\u53cd\u5e94\u6fc0\u6d3b\u4f11\u7720\u7684\u81ea\u53cd\u5e94\u6dcb\u5df4\u7ec6\u80de<\/li>\n\n\n\n<li>\u5fae\u751f\u7269\u8d85\u6297\u539f\u6fc0\u6d3b\u591a\u514b\u9686 B \u7ec6\u80de<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u9057\u4f20\u6613\u611f\u6027\u8d77\u7740\u4e00\u5b9a\u7684\u4f5c\u7528\uff0c\u4f46\u5177\u4f53\u7684\u98ce\u9669\u5355\u500d\u578b\u5c1a\u672a\u6700\u7ec8\u786e\u5b9a\u3002\u4e0e\u591a\u53d1\u6027\u786c\u5316\u75c7\u4e0d\u540c\u7684\u662f\uff0c\u76ee\u524d\u5c1a\u672a\u53d1\u73b0\u4e0e HLA \u6709\u5173\u8054\u7684\u75c5\u4f8b\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"T-Zell-vermittelte_Pathogenese\"><\/span>T \u7ec6\u80de\u4ecb\u5bfc\u7684\u53d1\u75c5\u673a\u5236<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">MOG \u7279\u5f02\u6027 CD4+ T \u7ec6\u80de\u5bf9 MOGAD \u53d1\u75c5\u81f3\u5173\u91cd\u8981\u3002\u5728\u52a8\u7269\u6a21\u578b\uff08EAE\uff09\u4e2d\uff0c\u6297\u4f53\u672c\u8eab\u5e76\u4e0d\u81f4\u75c5\uff1b\u5b83\u4eec\u9700\u8981\u81f4\u8111 T \u7ec6\u80de\u4f5c\u4e3a\u5171\u540c\u6548\u5e94\u56e0\u5b50\u3002CD4+ \u9014\u5f84\u5305\u62ec\u51e0\u4e2a\u9636\u6bb5\uff1a<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Phase_1_%E2%80%93_Periphere_Aktivierung\"><\/span>\u7b2c 1 \u9636\u6bb5--\u5916\u56f4\u6fc0\u6d3b<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">MOG \u80bd\u7531\u6297\u539f\u9012\u5448\u7ec6\u80de\uff08APC\uff09\u901a\u8fc7\u4ee5\u4e0b\u9014\u5f84\u4ea7\u751f <strong>MHC-II \u5206\u5b50<\/strong> \u5230\u5e7c\u7a1a\u7684 CD4+ T \u7ec6\u80de\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f <em>MOG \u80bd\u53ef\u76f4\u63a5\u4e0e\u5916\u5468 MHC II \u5206\u5b50\u7ed3\u5408<\/em>, \u65e0\u9700\u8fdb\u4e00\u6b65\u5904\u7406\u3002\u8fd9\u53ef\u4ee5\u89e3\u91ca\u4e3a\u4ec0\u4e48\u5916\u5468\u795e\u7ecf\u7cfb\u7edf\u4f1a\u53c2\u4e0e\u5176\u4e2d\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53ef\u5355\u72ec\u8bf1\u53d1 EAE \u7684\u6548\u5e94\u7ec6\u80de\u4e9a\u7fa4\u6709 <strong>Th1\u3001Th17 \u548c Th9<\/strong>. .Th17 \u7ec6\u80de\u4e0e MOGAD \u5c24\u4e3a\u76f8\u5173\uff0c\u56e0\u4e3a Th17 \u7ec6\u80de\u56e0\u5b50\uff08IL-17\u3001IL-21\uff09\u5728\u526a\u5207\u8fc7\u7a0b\u4e2d\u660e\u663e\u5347\u9ad8\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Phase_2_%E2%80%93_BHS-Penetration\"><\/span>\u7b2c 2 \u9636\u6bb5 - BHS \u7684\u6e17\u900f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u6d3b\u5316\u7684 CD4+ T \u7ec6\u80de\u8868\u8fbe\u7279\u5b9a\u7684\u7c98\u9644\u5206\u5b50\uff08\u6574\u5408\u7d20\u3001\u9009\u62e9\u7d20\uff09\u548c\u8d8b\u5316\u56e0\u5b50\u53d7\u4f53\uff08\u7279\u522b\u662f <strong>CCR6<\/strong>)\uff0c\u4f7f\u5b83\u4eec\u80fd\u591f\u8fdb\u5165\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u3002CCR6+ Th17 \u7ec6\u80de\u4e0e\u8109\u7edc\u4e1b\u4e2d\u8fde\u7eed\u8868\u8fbe\u7684 CCL20 \u7ed3\u5408\uff0c\u5e76\u901a\u8fc7\u5b83\u8fdb\u5165\u86db\u7f51\u819c\u4e0b\u8154\u3002.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u57fa\u8d28\u91d1\u5c5e\u86cb\u767d\u9176\uff08MMP-2\u3001MMP-9\uff09<br>BBB \u57fa\u5e95\u819c\u964d\u89e3<\/li>\n\n\n\n<li>\u4e2d\u6027\u7c92\u7ec6\u80de\u7f51\uff08\u4e2d\u6027\u7c92\u7ec6\u80de\u80de\u5916\u6355\u83b7\u5668\uff09<br>\u5728\u542f\u52a8\u9636\u6bb5\u4e3a T \u7ec6\u80de\u63d0\u4f9b\u6210\u672c\u523a\u6fc0\u4fe1\u53f7<\/li>\n\n\n\n<li>\u8840\u5c0f\u677f<br>\u901a\u8fc7\u7ec6\u80de\u56e0\u5b50\u548c\u7c98\u9644\u5206\u5b50\u4fc3\u8fdb CD4+ T \u7ec6\u80de\u589e\u6b96\u5e76\u5411 Th1\/Th17 \u5206\u5316<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Phase_3_%E2%80%93_Perivaskulare_Reaktivierung\"><\/span>\u7b2c 3 \u9636\u6bb5--\u8840\u7ba1\u5468\u56f4\u518d\u6fc0\u6d3b<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u8840\u7ba1\u5468\u56f4\u95f4\u9699\u548c\u86db\u7f51\u819c\u4e0b\u8154\uff0cMOG \u7279\u5f02\u6027 T \u7ec6\u80de\u4f1a\u88ab\u5f53\u5730\u7684 MOG \u8f7d\u4f53 APC\uff08\u5c0f\u80f6\u8d28\u7ec6\u80de\u3001\u6811\u7a81\u72b6\u7ec6\u80de\uff09\u91cd\u65b0\u6fc0\u6d3b\u3002\u8fd9\u79cd\u91cd\u65b0\u6fc0\u6d3b\u89e6\u53d1\u4e86\u5b9e\u9645\u7684\u708e\u75c7\u7ea7\u8054\u53cd\u5e94\uff1a\u5206\u6ccc\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\u3001\u62db\u52df\u66f4\u591a\u767d\u7ec6\u80de\u548c\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u635f\u4f24\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"B-Zell-_und_Antikorper-vermittelte_Pathogenese\"><\/span>B \u7ec6\u80de\u548c\u6297\u4f53\u4ecb\u5bfc\u7684\u53d1\u75c5\u673a\u5236<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">MOG \u7279\u5f02\u6027 B \u7ec6\u80de\u548c\u6d46\u7ec6\u80de\u662f\u81f4\u75c5\u6027 IgG1 \u81ea\u8eab\u6297\u4f53\u7684\u4e3b\u8981\u4ea7\u751f\u8005\u3002\u7136\u800c\uff0cB \u7ec6\u80de\u7684\u4f5c\u7528\u5e76\u4e0d\u5c40\u9650\u4e8e\u4ea7\u751f\u6297\u4f53\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6297\u539f\u9012\u5448--B \u7ec6\u80de\u53ef\u901a\u8fc7\u5176 BCR \u4e0e MOG \u6784\u8c61\u8868\u4f4d\uff08CC'\u73af\u7684 pro42\u3001his103 \u548c ser104\uff09\u7ed3\u5408\uff0c\u5e76\u5145\u5f53 T \u7ec6\u80de\u7684 APC<\/li>\n\n\n\n<li>\u4fc3\u8fdb Th17 \u5206\u5316--B \u7ec6\u80de\u5206\u6ccc IL-6\uff0c\u4e0e TGF-\u03b2 \u5171\u540c\u4fc3\u8fdb Th17 \u5206\u5316<\/li>\n\n\n\n<li>MAPK \u548c AKT \u4fe1\u53f7\u6fc0\u6d3b - BCR \u4e0e MOG \u7ed3\u5408\u53ef\u6fc0\u6d3b\u7ec6\u80de\u5185\u7684\u8fd9\u4e9b\u4fe1\u53f7\u901a\u8def<\/li>\n\n\n\n<li>\u7ec6\u80de\u5185\u9499\u589e\u52a0 - \u5bfc\u81f4\u538b\u529b\u76f8\u5173\u4fe1\u53f7\u7ea7\u8054\u6fc0\u6d3b<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u5927\u591a\u6570 MOG-IgG \u6297\u4f53\u4ea7\u751f\u4e8e\u5916\u5468\uff08\u53ea\u6709\u7ea6 10 % \u7684\u75c5\u4f8b\u5728 CSF \u4e2d\u51fa\u73b0\u5be1\u514b\u9686\u5e26\uff0c\u76f8\u6bd4\u4e4b\u4e0b\uff1aMS \u7ea6\u4e3a 90 %\uff09\u3002\u6297\u4f53\u662f <strong>\u4e8c\u4ef7\u7ed3\u5408<\/strong> \u4e0e MOG \u7ed3\u5408\u65f6\uff0c\u4e24\u4e2a Fab \u81c2\u540c\u65f6\u4e0e\u4e24\u4e2a\u76f8\u90bb\u7684 MOG \u5206\u5b50\u7ed3\u5408\u3002\u8fd9\u5bfc\u81f4\u5728 NMOSD \u4e2d\uff0c\u4e0e AQP4-IgG \u7684\u5355\u4ef7\u7ed3\u5408\u76f8\u6bd4\uff0cC1q \u7684\u62db\u52df\u6548\u7387\u8f83\u4f4e\u3002.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Molekulare_Signalwege_und_Effektormechanismen\"><\/span>\u5206\u5b50\u4fe1\u53f7\u901a\u8def\u548c\u6548\u5e94\u673a\u5236<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Signalweg_1_%E2%80%93_Klassischer_Komplementweg_CDC\"><\/span>\u4fe1\u53f7\u901a\u8def 1 - \u7ecf\u5178\u8865\u4f53\u9014\u5f84 (CDC)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u5982\u679c MOG-IgG1\uff08\u548c MOG-IgG3\uff09\u4e0e\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de MOG \u7ed3\u5408\uff0c\u5219 <strong>\u7ecf\u5178\u4e92\u8865\u8def\u7ebf<\/strong> \u88ab\u6fc0\u6d3b\u3002\u7136\u800c\uff0cMOGAD \u7684\u8865\u4f53\u6fc0\u6d3b\u6bd4 AQP4+ NMOSD \u5f31\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>C1q \u4e0e\u7ed3\u5408\u7684 IgG1 \u6297\u4f53\u7684 Fc \u90e8\u5206\u7ed3\u5408 \u2192 \u6fc0\u6d3b C1r \u548c C1s<\/li>\n\n\n\n<li>\u88c2\u89e3 C4 \u2192 C4a + C4b\uff1bC4b + C2 \u2192 C3 \u8f6c\u5316\u9176\uff08C4b2a\uff09<\/li>\n\n\n\n<li>\u88c2\u89e3 C3 \u2192 C3a\uff08\u8fc7\u654f\u6bd2\u7d20\uff09+ C3b\uff08\u86cb\u767d\u6eb6\u89e3\u7d20\uff09<\/li>\n\n\n\n<li>C3b \u2192 C5 \u8f6c\u5316\u9176 \u2192 C5 \u7684\u88c2\u89e3 \u2192 C5a\uff08\u5f3a\u6548\u65e0\u76f8\u5bb9\u6027\u6bd2\u7d20\uff09+ C5b<\/li>\n\n\n\n<li>C5b + C6\u3001C7\u3001C8\u3001C9 \u2192 \u819c\u653b\u51fb\u590d\u5408\u7269\uff08MAC\uff0cC5b-9\uff09\uff1a\u76f4\u63a5\u88c2\u89e3\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u91cd\u8981\u4fe1\u606f\uff1a\u5728 MOGAD \u60a3\u8005\u7684\u8111\u810a\u6db2\u4e2d\uff0cC3a \u548c C5a \u660e\u663e\u589e\u52a0\uff08\u4e0e AQP4+ NMOSD \u76f8\u4f3c\uff09\uff0c\u4f46 MAC \u590d\u5408\u7269\uff08C5b-9\uff09\u5e76\u672a\u660e\u663e\u589e\u52a0\u3002 <strong>\u5927\u5e45\u51cf\u5c11<\/strong> \u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u7684\u8865\u4f53\u8c03\u8282\u56e0\u5b50\u5bc6\u5ea6\u6bd4 NMOSD \u4f4e\u3002\u8fd9\u662f\u7531\u4e8e\u4e8c\u4ef7 IgG \u7684\u7ed3\u5408\u5bf9 C1q \u805a\u7c7b\u7684\u6548\u7387\u8f83\u4f4e\uff0c\u4ee5\u53ca\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u4e0a\u8865\u4f53\u8c03\u8282\u5242\u7684\u5bc6\u5ea6\u76f8\u5bf9\u8f83\u4f4e\uff08CR1\u3001MCP\u3001HRF \u7684\u542b\u91cf\u4f4e\u4e8e\u5176\u4ed6\u7ec6\u80de\u7c7b\u578b\uff09\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Signalweg_2_%E2%80%93_Fc%CE%B3-Rezeptor-Weg_FcR-vermittelt\"><\/span>\u4fe1\u53f7\u901a\u8def 2 - Fc\u03b3 \u53d7\u4f53\u901a\u8def\uff08FcR \u4ecb\u5bfc\uff09<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">LMU \u7684\u7814\u7a76\uff08Mader\u3001Kawakami\u3001Meinl\uff0c2024 \u5e74 PNAS\uff09\u663e\u793a\uff0cFc\u03b3 \u53d7\u4f53\uff08Fc\u03b3R\uff09\u4ecb\u5bfc\u7684\u673a\u5236 <strong>\u5230\u7ea6 50 % \u7684\u9ad3\u9798\u635f\u4f24<\/strong> \u56e0\u6b64\uff0c\u5b83\u4eec\u4e0e\u8865\u4f53\u6fc0\u6d3b\u5177\u6709\u540c\u7b49\u4f5c\u7528\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Fc\u03b3RIII<\/strong> (<strong>CD16<\/strong>\uff09\u5bf9 NK \u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\u7684\u5f71\u54cd<br>\u7ed3\u5408 MOG \u7ed3\u5408 IgG1 \u7684 Fc \u90e8\u5206 \u2192 ADCC\uff08\u6297\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u6bd2\u6027\uff09<\/li>\n\n\n\n<li><strong>Fc\u03b3RI\/II\/III<\/strong> \u5de8\u566c\u7ec6\u80de\u548c\u5355\u6838\u7ec6\u80de<br>\u541e\u566c MOG \u51b2\u6d17\u8fc7\u7684\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u7247\u6bb5\uff08ADCP\uff09<\/li>\n\n\n\n<li>\u51b3\u5b9a\u6027\u56e0\u7d20\uff1a\u7b2c\u4e8c\u4e2a FcR \u8def\u5f84\u673a\u5236<br>\u589e\u5f3a T \u7ec6\u80de\u6d3b\u5316\uff0c\u4ec5\u901a\u8fc7 Fc \u53d7\u4f53\u8fd0\u884c\uff0c\u800c\u975e\u8865\u4f53\u9014\u5f84<\/li>\n\n\n\n<li><strong>Fc\u03b3R<\/strong> \u6811\u7a81\u72b6\u7ec6\u80de<br>\u4fc3\u8fdb\u88c5\u8f7d MOG-IgG \u7684\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u6297\u539f\u7684\u5904\u7406\u548c\u5448\u73b0\u7ed9 MOG \u7279\u5f02\u6027 T \u7ec6\u80de<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e34\u5e8a\u610f\u4e49\uff1a\u7531\u4e8e\u5b58\u5728\u4e24\u79cd\u72ec\u7acb\u7684\u81f4\u75c5\u9014\u5f84\uff0c\u56e0\u6b64\u6cbb\u7597\u65b9\u6cd5\u5fc5\u987b <strong>\u4e24\u79cd\u673a\u5236<\/strong> \u4ee5\u53d6\u5f97\u6700\u5927\u6210\u6548\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Signalweg_3_%E2%80%93_IL-6JAK-STAT3-Weg\"><\/span>\u4fe1\u53f7\u901a\u8def 3 - IL-6\/JAK-STAT3 \u901a\u8def<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">IL-6 \u662f MOGAD \u514d\u75ab\u53d1\u75c5\u673a\u5236\u7684\u6838\u5fc3\u4ecb\u8d28\uff0c\u5728\u591a\u4e2a\u5c42\u9762\u53d1\u6325\u4f5c\u7528\uff1a<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">IL-6 \u4e0e\u5176\u53d7\u4f53\uff08IL-6R\u03b1\/gp130 \u590d\u5408\u7269\uff09\u7ed3\u5408\uff0c\u4ece\u800c\u5bfc\u81f4 <strong>JAK1\/2 \u78f7\u9178\u5316<\/strong> \u5bfc\u7ebf\u3002\u8fd9\u4e3b\u8981\u6fc0\u6d3b <strong>STAT3<\/strong>, \u7684\u8f6c\u5f55\u56e0\u5b50\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Th17 \u5206\u5316<\/strong><br>IL-6 + TGF-\u03b2 \u2192 ROR\u03b3t \u8868\u8fbe \u2192 IL-17A\/F \u4ea7\u751f\uff1bIL-6 + IL-23 \u2192 \u7ef4\u6301 Th17 \u8868\u578b<\/li>\n\n\n\n<li><strong>\u53f6\u72b6 T \u8f85\u52a9\u7ec6\u80de<\/strong> (<strong>Tfh<\/strong>)<br>IL-6 \u2192 STAT3 \u2192 Bcl6 \u8868\u8fbe \u2192 \u751f\u6b96\u4e2d\u5fc3 B \u7ec6\u80de\u6210\u719f\u548c IgG \u7c7b\u522b\u8f6c\u6362<\/li>\n\n\n\n<li><strong>B \u7ec6\u80de\u6210\u719f\u4e3a\u6d46\u7ec6\u80de<\/strong><br>IL-6 \u901a\u8fc7 STAT3\/Blimp-1 \u8f74\u4fc3\u8fdb\u5206\u5316<\/li>\n\n\n\n<li><strong>\u6291\u5236 Treg \u529f\u80fd<\/strong><br>IL-6 \u53ef\u6291\u5236 FoxP3 \u7684\u8868\u8fbe\uff0c\u4ece\u800c\u4f7f Treg\/Th17 \u5e73\u8861\u5411\u708e\u75c7\u65b9\u5411\u8f6c\u53d8<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u6cbb\u7597\u76f8\u5173\u6027\uff1aIL-6\u963b\u65ad\u5242\uff08\u5982\u59a5\u73e0\u5355\u6297\u3001\u6c99\u59a5\u73e0\u5355\u6297\uff09\u53ef\u6253\u7834\u8fd9\u4e00\u5faa\u73af\u3002. <strong><em>Satralizumab<\/em><\/strong> (\u6297 IL-6R\uff09\u76ee\u524d\u6b63\u5728\u8fdb\u884c MOGAD \u7684 3 \u671f METEOROID \u8bd5\u9a8c\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Signalweg_4_%E2%80%93_MAPK-_und_AKT-Signalwege_B-Zellen\"><\/span>\u4fe1\u53f7\u901a\u8def 4 - MAPK \u548c AKT \u4fe1\u53f7\u901a\u8def\uff08B \u7ec6\u80de\uff09<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">BCR \u4e0e B \u7ec6\u80de\u4e2d\u6fc0\u6d3b\u7684 MOG \u6784\u8c61\u8868\u4f4d\u7ed3\u5408\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>MAPK \u8def\u5f84<\/strong> (<strong>MEK\/ERK<\/strong>)<br>\u4fc3\u8fdb B \u7ec6\u80de\u589e\u6b96\u548c\u5206\u5316<\/li>\n\n\n\n<li><strong>PI3K\/AKT \u8def\u5f84<\/strong><br>\u7ec6\u80de\u5b58\u6d3b\u548c B \u7ec6\u80de\u5411\u6d46\u7ec6\u80de\u7684\u5206\u5316<\/li>\n\n\n\n<li><strong>\u9499\u6d41\u5165<\/strong><br>\u6fc0\u6d3b\u9499\u795e\u7ecf\u86cb\u767d\/NFAT \u8f74 \u2192 \u7ec6\u80de\u56e0\u5b50\u7684\u4ea7\u751f<\/li>\n\n\n\n<li><strong>\u6fc0\u6d3b NK \u7ec6\u80de<\/strong><br>BCR-MOG \u7ed3\u5408\u53ef\u8bf1\u5bfc NK \u7ec6\u80de\u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\u6027<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Signalweg_5_%E2%80%93_Th17-Zytokin-Netzwerk_im_ZNS\"><\/span>\u4fe1\u53f7\u901a\u8def 5--\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u4e2d\u7684 Th17 \u7ec6\u80de\u56e0\u5b50\u7f51\u7edc<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u4e2d\uff0cTh17 \u7ec6\u80de\u901a\u8fc7\u591a\u79cd\u4ecb\u8d28\u7ef4\u6301\u708e\u75c7\u73af\u5883\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>IL-17A \u548c IL-17F<\/strong><br>\u6fc0\u6d3b\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u548c\u5c0f\u80f6\u8d28\u7ec6\u80de\uff1b\u8bf1\u5bfc\u91ca\u653e\u8d8b\u5316\u56e0\u5b50\uff08CXCL-1\/5\/8\uff09\uff0c\u62db\u52df\u4e2d\u6027\u7c92\u7ec6\u80de<\/li>\n\n\n\n<li><strong>IL-21<\/strong> (\u81ea\u5206\u6ccc\u548c\u65c1\u5206\u6ccc\uff09<br>\u589e\u5f3a Th17 \u5206\u5316\uff1b\u4fc3\u8fdb B \u7ec6\u80de\u5206\u5316\u548c IgG \u7c7b\u522b\u8f6c\u6362\uff08\u5c24\u5176\u662f IgG1\uff09<\/li>\n\n\n\n<li><strong>IL-22<\/strong><br>BBB \u5b8c\u6574\u6027\u5931\u8c03<\/li>\n\n\n\n<li><strong>GM-CSF<\/strong> (<strong>\u901a\u8fc7 IL-23<\/strong>)<br>\u6fc0\u6d3b\u5c0f\u80f6\u8d28\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\uff0c\u52a0\u5267\u5c40\u90e8\u8131\u9ad3\u9798<\/li>\n\n\n\n<li><strong>CXCL13<\/strong><br>B \u7ec6\u80de\u5728\u8840\u7ba1\u5468\u56f4\u7a7a\u95f4\u7684\u8d8b\u5316\u4f5c\u7528 \u2192 \u4ea7\u751f\u5c40\u90e8\u6297\u4f53<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Signalwege_%E2%80%93_Ubersicht\"><\/span>\u4fe1\u53f7\u901a\u8def - \u6982\u8ff0<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><td><strong>\u4fe1\u53f7\u8def\u5f84<\/strong><\/td><td><strong>\u5173\u952e\u5206\u5b50<\/strong><\/td><td><strong>\u6548\u679c<\/strong><\/td><td><strong>\u6cbb\u7597\u76ee\u6807<\/strong><\/td><\/tr><\/thead><tbody><tr><td>\u7ecf\u5178\u4e92\u8865\u8def\u7ebf<\/td><td>C1q\u3001C3\u3001C5\u3001MAC\uff08C5b-9\uff09<\/td><td>\u76f4\u63a5\u6eb6\u89e3\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de<\/td><td>C5 \u6291\u5236\u5242\uff08\u4f9d\u5e93\u73e0\u5355\u6297\uff09\u3001C3 \u6291\u5236\u5242<\/td><\/tr><tr><td>Fc\u03b3R \u8def\u5f84\uff08ADCC\/ADCP\uff09<\/td><td>Fc\u03b3RI\/II\/III\u3001NK \u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de<\/td><td>\u7ec6\u80de\u6bd2\u6027\u3001\u541e\u566c\u4f5c\u7528\u3001T \u7ec6\u80de\u589e\u6548\u4f5c\u7528<\/td><td>FcRn \u6291\u5236\u5242\uff08IgG \u964d\u89e3\uff09\u3001FcR \u963b\u65ad\u5242<\/td><\/tr><tr><td>IL-6\/JAK-STAT3<\/td><td>IL-6\u3001IL-6R\u03b1\u3001gp130\u3001JAK1\/2\u3001STAT3\u3001ROR\u03b3t<\/td><td>Th17 \u5206\u5316\u3001B \u7ec6\u80de\u6210\u719f\u3001IgG \u751f\u6210<\/td><td>\u6297IL-6R\uff08\u6258\u73e0\u5355\u6297\u3001\u6c99\u59a5\u73e0\u5355\u6297\uff09<\/td><\/tr><tr><td>PI3K\/AKT\/MAPK \uff08B \u7ec6\u80de\uff09<\/td><td>BTK\u3001PI3K\u3001AKT\u3001ERK\u3001NFAT<\/td><td>B \u7ec6\u80de\u6d3b\u5316\u3001\u6d46\u7ec6\u80de\u6210\u719f<\/td><td>BTK \u6291\u5236\u5242\uff08\u4f0a\u5e03\u66ff\u5c3c\u3001\u6258\u4e50\u5e03\u66ff\u5c3c\uff09<\/td><\/tr><tr><td>Th17 \u7ec6\u80de\u56e0\u5b50\u7f51\u7edc<\/td><td>IL-17\u3001IL-21\u3001IL-22\u3001GM-CSF\u3001CXCL13<\/td><td>BBB \u635f\u4f24\u3001\u767d\u7ec6\u80de\u52df\u96c6\u3001\u8131\u9ad3\u9798<\/td><td>\u6297 IL-17\u3001\u6297 IL-21<\/td><\/tr><tr><td>FcRn-IgG \u5faa\u73af<\/td><td>FcRn\uff08\u65b0\u751f\u513f Fc \u53d7\u4f53\uff09<\/td><td>\u5ef6\u957f IgG \u7684\u534a\u8870\u671f<\/td><td>\u6297 FcRn\uff08\u7f57\u624e\u5c3c\u5355\u6297\uff09<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h1 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Relevante_Rezeptoren_und_Zielmolekule\"><\/span>\u76f8\u5173\u53d7\u4f53\u548c\u76ee\u6807\u5206\u5b50<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"MOG_selbst_als_Zielstruktur_kein_klassischer_Rezeptor\"><\/span>MOG \u672c\u8eab\u662f\u4e00\u79cd\u76ee\u6807\u7ed3\u6784\uff08\u800c\u4e0d\u662f\u5178\u578b\u7684\u53d7\u4f53\uff09<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728 MOGAD \u4e2d\uff0cMOG \u86cb\u767d\u8d77\u7740\u6297\u539f\u800c\u975e\u4fe1\u53f7\u53d7\u4f53\u7684\u4f5c\u7528\u3002\u7136\u800c\uff0c\u4e0b\u5217\u76f8\u4e92\u4f5c\u7528\u5177\u6709\u91cd\u8981\u7684\u75c5\u7406\u751f\u7406\u610f\u4e49\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>C1q \u7ed3\u5408<\/strong><br>MOG \u53ef\u4e0e C1q \u53d1\u751f\u751f\u7406\u6027\u7ed3\u5408\uff0c\u5728\u75c5\u7406\u6297\u4f53\u8986\u76d6\u7684\u60c5\u51b5\u4e0b\u5bfc\u81f4\u8865\u4f53\u6fc0\u6d3b\u3002<\/li>\n\n\n\n<li><strong>\u76f4\u6d41\u6807\u5fd7\uff08CD209\uff09<\/strong><br>\u6811\u7a81\u72b6\u7ec6\u80de\u4e0a\u7684\u51dd\u96c6\u7d20\u53d7\u4f53\uff1b\u53ef\u7ed3\u5408 MOG \u5e76\u4fc3\u8fdb\u6297\u539f\u9012\u5448<\/li>\n\n\n\n<li><strong>\u98ce\u75b9\u75c5\u6bd2\u53d7\u4f53<\/strong>_<br>MOG \u662f\u98ce\u75b9\u75c5\u6bd2\u7684\u8fdb\u5165\u5206\u5b50\uff0c\u8fd9\u53ef\u4ee5\u89e3\u91ca\u513f\u7ae5\u611f\u67d3\u540e ADEM \u7684\u539f\u56e0<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Fc%CE%B3-Rezeptoren_Fc%CE%B3R\"><\/span>Fc\u03b3 \u53d7\u4f53\uff08Fc\u03b3R\uff09<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u514d\u75ab\u7ec6\u80de\u4e0a\u7684 Fc\u03b3 \u53d7\u4f53\u662f IgG1 \u4ecb\u5bfc\u7684\u635f\u4f24\u7684\u6838\u5fc3\u6548\u5e94\u5668\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Fc\u03b3RI (CD64)<\/strong><br>\u9ad8\u4eb2\u548c\u529b\uff0c\u4f5c\u7528\u4e8e\u5de8\u566c\u7ec6\u80de\u548c\u6811\u7a81\u72b6\u7ec6\u80de\uff1b\u4ecb\u5bfc ADCP \u548c\u6297\u539f\u9012\u5448<\/li>\n\n\n\n<li><strong>Fc\u03b3RIII (CD16)<\/strong><br>\u4f4e\u4eb2\u548c\u529b\uff0c\u4f5c\u7528\u4e8e NK \u7ec6\u80de\uff1b\u9488\u5bf9 MOG \u4e0a\u76ae\u7ec6\u80de\u5316\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u7684 ADCC \u7684\u4e3b\u8981\u4ecb\u8d28<\/li>\n\n\n\n<li><strong>Fc\u03b3RIIA\/B (CD32A\/B)<\/strong><br>\u6fc0\u6d3b\u6216\u6291\u5236\uff1b\u8c03\u8282 B \u7ec6\u80de\u6d3b\u5316\u548c\u541e\u566c\u4f5c\u7528<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Neonataler_Fc-Rezeptor_FcRn\"><\/span>\u65b0\u751f\u513f Fc \u53d7\u4f53\uff08FcRn\uff09<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">FcRn\uff08\u03b22m\/FcRn-\u03b1 \u590d\u5408\u7269\uff09\u8d1f\u8d23 IgG \u6297\u4f53\u7684\u7ec6\u80de\u5185\u5faa\u73af\u3002\u5b83\u4e0e\u9178\u5316\u5185\u4f53\uff08pH \u503c\u4e3a 6.0\uff09\u4e2d\u7684 IgG \u7ed3\u5408\uff0c\u963b\u6b62\u5176\u6eb6\u9176\u4f53\u964d\u89e3\uff0c\u4ece\u800c\u5c06 IgG \u7684\u534a\u8870\u671f\u5ef6\u957f\u81f3\u7ea6 21 \u5929\u3002.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5728 MOGAD \u4e2d\uff0cFcRn \u5bfc\u81f4\u81f4\u75c5\u6027 MOG-IgG1 \u6301\u7eed\u5faa\u73af<\/li>\n\n\n\n<li>\u6cbb\u7597\u963b\u585e\u7684\u539f\u56e0\u662f <em>\u7f57\u624e\u5c3c\u73e0\u5355\u6297<\/em> (\u6297 FcRn IgG4\uff09\uff1a\u8feb\u4f7f\u6eb6\u9176\u4f53 IgG \u964d\u89e3\uff0c\u5c06\u8840\u6d46 IgG \u964d\u4f4e\u7ea6 50%<\/li>\n\n\n\n<li>FcRn \u8868\u8fbe - \u4e0a\u76ae\u7ec6\u80de\u3001\u5185\u76ae\u7ec6\u80de\u3001\u5355\u6838\u7ec6\u80de\u3001\u809d\u7ec6\u80de<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"IL-6-Rezeptor_IL-6R%CE%B1_gp130\"><\/span>IL-6 \u53d7\u4f53\uff08IL-6R\u03b1 \/ gp130\uff09<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">IL-6 \u53d7\u4f53\u7531\u914d\u4f53\u7ed3\u5408 \u03b1 \u4e9a\u57fa\uff08IL-6R\u03b1\uff0cCD126\uff09\u548c\u4fe1\u53f7\u5171\u53d7\u4f53 gp130\uff08IL-6R\u03b2\uff0cCD130\uff09\u7ec4\u6210\u3002\u4e24\u79cd\u4fe1\u53f7\u6a21\u5f0f\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7ecf\u5178\u4fe1\u53f7<\/strong><br>T \u7ec6\u80de\u3001B \u7ec6\u80de\u3001\u5355\u6838\u7ec6\u80de\u4e0a\u4e0e\u819c\u7ed3\u5408\u7684 IL-6R\u03b1 \u2192 IL-6\/IL-6R\u03b1\/gp130 \u590d\u5408\u7269 \u2192 JAK1\/2 \u2192 STAT3\u3001STAT1\u3001MAPK\u3001PI3K\/AKT<\/li>\n\n\n\n<li><strong>\u8f6c\u53d1\u4fe1\u53f7<\/strong><br>\u53ef\u6eb6\u6027 IL-6R\u03b1\uff08sIL-6R\uff09\u53ef\u7ed3\u5408 IL-6\uff0c\u5e76\u6fc0\u6d3b gp130\uff0c\u5373\u4f7f\u5728\u6ca1\u6709\u819c\u7ed3\u5408 IL-6R\u03b1 \u7684\u7ec6\u80de\uff08\u5982 BBB \u7684\u5185\u76ae\u7ec6\u80de\uff09\u4e0a\u4e5f\u662f\u5982\u6b64\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u76f8\u5173\u4e0b\u6e38\u6548\u5e94\uff1aROR\u03b3t \u8868\u8fbe\uff08Th17\uff09\u3001Bcl-6\uff08Tfh \u548c\u751f\u6b96\u4e2d\u5fc3\uff09\u3001Blimp-1\uff08\u6d46\u7ec6\u80de\uff09\u3001\u6291\u5236 FoxP3\uff08Treg\uff09\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"T-Zell-Rezeptor_TCR_und_Kostimulationsmolekule\"><\/span>T \u7ec6\u80de\u53d7\u4f53 (TCR) \u548c\u6210\u672c\u523a\u6fc0\u5206\u5b50<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>TCR\/MHC-II-MOG \u80bd\u590d\u5408\u7269<\/strong><br>MOG \u7279\u5f02\u6027 CD4+ T \u7ec6\u80de\u7684\u4e2d\u5fc3\u6fc0\u6d3b\u8f74<\/li>\n\n\n\n<li><strong>CD28\/B7<\/strong><br>T \u7ec6\u80de\u6d3b\u5316\u8fc7\u7a0b\u4e2d\u7684\u6210\u672c\u523a\u6fc0<\/li>\n\n\n\n<li><strong>CCR6\/CCL20 \u8f74<\/strong><br>Th17 \u7ec6\u80de\u4e0a\u7684 CCR6 \u4e0e\u8109\u7edc\u4e1b\u4e2d\u7684 CCL20 \u7ed3\u5408\u2192\u8fdb\u5165\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf<\/li>\n\n\n\n<li><strong>CXCR3\/CXCL10<\/strong><br>\u708e\u75c7\u533a\u57df Th1 \u7ec6\u80de\u7684\u8d8b\u5316\u4f5c\u7528<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Komplementrezeptoren\"><\/span>\u8865\u4f53\u53d7\u4f53<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>C1qR<\/strong><br>\u4ecb\u5bfc C1q \u4e0e\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u819c\u4e0a\u7684\u514d\u75ab\u590d\u5408\u7269\u7ed3\u5408<\/li>\n\n\n\n<li><strong>C3aR <\/strong>\u548c<strong> C5aR1 (CD88)<\/strong><br>\u5c0f\u80f6\u8d28\u7ec6\u80de\/\u5de8\u566c\u7ec6\u80de\u4e0a\u7684 Anaphylatoxin \u53d7\u4f53 \u2192 \u4fc3\u708e\u6fc0\u6d3b<\/li>\n\n\n\n<li><strong>\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u4e0a\u7684\u8865\u4f53\u8c03\u8282\u56e0\u5b50<\/strong><br>CR1 (CD35)\u3001MCP (CD46)\u3001HRF (CD59) \u5728\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u4e0a\u7684\u8868\u8fbe\u91cf\u5f88\u4f4e\uff0c\u56e0\u6b64\u5b83\u4eec\u6bd4\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u66f4\u5bb9\u6613\u53d7\u5230\u8865\u4f53\u635f\u4f24\uff0c\u4f8b\u5982<\/li>\n<\/ul>\n\n\n\n<h1 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Histopathologie_und_ZNS-Lasionsmuster\"><\/span>\u7ec4\u7ec7\u75c5\u7406\u5b66\u548c\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75c5\u53d8\u6a21\u5f0f<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">MOGAD \u75c5\u53d8\u5728\u7ec4\u7ec7\u75c5\u7406\u5b66\u4e0a\u4e0e MS \u548c NMOSD \u6709\u672c\u8d28\u533a\u522b\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5468\u56f4\u8131\u9ad3\u9798<\/strong><br>\u75c5\u53d8\u5728\u5c0f\u9759\u8109\u5468\u56f4\u96c6\u4e2d\u5f62\u6210\uff08\u9759\u8109\u5468\u56f4\u578b\uff09\uff0c\u800c\u4e0d\u662f\u50cf\u591a\u53d1\u6027\u786c\u5316\u75c7\u90a3\u6837\u5728\u8f74\u5468\u5f62\u6210\u3002\u6838\u78c1\u5171\u632f\u6210\u50cf\u4e0a\u6ca1\u6709\u591a\u53d1\u6027\u786c\u5316\u75c7\u5178\u578b\u7684 \u201a\u4e2d\u592e\u9759\u8109\u5f81\u2018\u3002<\/li>\n\n\n\n<li><strong>CD4+ T \u7ec6\u80de\u6d78\u6da6<\/strong><br>\u4e3b\u8981\u708e\u75c7\u7ec6\u80de\u5f62\u6001\u4e3a CD4+ T \u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\uff0c\u4e2d\u6027\u7c92\u7ec6\u80de\u8f83\u5c11\uff0c\u51e0\u4e4e\u6ca1\u6709\u55dc\u9178\u6027\u7c92\u7ec6\u80de\uff08\u4e0e AQP4+ NMOSD \u4e0d\u540c\uff09\u3002<\/li>\n\n\n\n<li><strong>\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u635f\u4f24<\/strong> \uff08\u521d\u7ea7\uff09<br>\u4e0e\u4e3b\u8981\u635f\u4f24\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u7684 NMOSD \u4e0d\u540c\uff0cMOGAD \u7684\u7279\u70b9\u662f\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u53d8\u6027<\/li>\n\n\n\n<li><strong>C9neo \u6c89\u79ef<\/strong><br>\u5728\u75c5\u53d8\u90e8\u4f4d\u68c0\u6d4b\u5230 MAC\uff08\u672b\u7aef\u8865\u4f53\u590d\u5408\u7269\uff09\uff0c\u5c3d\u7ba1\u6bd4 NMOSD \u5f31<\/li>\n\n\n\n<li><strong>\u8f74\u7a81\u7684\u76f8\u5bf9\u4fdd\u62a4<\/strong><br>\u5728\u6025\u6027\u53d1\u4f5c\u65f6\uff0c\u8f74\u7d22\u635f\u4f24\u5f80\u5f80\u6ca1\u6709\u591a\u53d1\u6027\u786c\u5316\u75c7\u4e25\u91cd\uff0c\u8fd9\u4e5f\u662f\u4e34\u5e8a\u6062\u590d\u826f\u597d\u7684\u539f\u56e0\u6240\u5728<\/li>\n\n\n\n<li><strong>\u76ae\u8d28\u75c5\u53d8<\/strong><br>\u8111\u819c\u708e\u75c7\u548c\u76ae\u8d28\u8131\u9ad3\u9798\uff08\u5e38\u89c1\u4e8e ADEM \u53d8\u4f53\uff09<\/li>\n<\/ul>\n\n\n\n<h1 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Klinische_Manifestationen_und_Phanotypen\"><\/span>\u4e34\u5e8a\u8868\u73b0\u548c\u8868\u578b<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">MOGAD \u5728\u4e34\u5e8a\u4e0a\u5177\u6709\u5f02\u8d28\u6027\u3002\u91cd\u8981\u8868\u578b\uff1a<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><td><strong>\u8868\u578b<\/strong><\/td><td><strong>\u9891\u7387<\/strong><\/td><td><strong>\u4e34\u5e8a\u7279\u5f81<\/strong><\/td><td><strong>\u78c1\u5171\u632f\u6210\u50cf\u4e13\u4e1a<\/strong><\/td><\/tr><\/thead><tbody><tr><td>\u89c6\u795e\u7ecf\u708e\uff08ON\uff09<\/td><td>\u6700\u5e38\u89c1\uff08\u7ea6 50%\uff09<\/td><td>\u5e38\u4e3a\u53cc\u4fa7\u3001\u89c6\u529b\u4e27\u5931\u3001\u7403\u540e\u3001\u773c\u7403\u8fd0\u52a8\u75bc\u75db\u3002\u773c\u7403\u8fd0\u52a8<\/td><td>\u89c6\u795e\u7ecf\u957f\u671f\u53d7\u7d2f\uff0c\u795e\u7ecf\u5468\u56f4\u9020\u5f71\u5242\u79ef\u805a<\/td><\/tr><tr><td>\u6a2a\u8d2f\u6027\u810a\u9ad3\u708e<\/td><td>\u7ea6 30%<\/td><td>\u7eb5\u5411\u810a\u9ad3\u708e\uff08LETM\uff09\u3001\u611f\u89c9\/\u8fd0\u52a8\u3001\u8180\u80f1\u529f\u80fd\u969c\u788d<\/td><td>\u7eb5\u5411 T2 \u75c5\u53d8\uff0cH2 \u7efc\u5408\u5f81\uff08\u201a\u900f\u955c\u72b6\u2018\uff09\u3002<\/td><\/tr><tr><td>ADEM<\/td><td>\u513f\u7ae5\u6700\u5e38\u89c1\u7684\u8868\u73b0<\/td><td>\u8111\u75c5\u3001\u591a\u7076\u6027\u795e\u7ecf\u529f\u80fd\u7f3a\u635f\u7f3a\u635f<\/td><td>\u53cc\u4fa7\u5927\u5bb9\u79ef T2 \u75c5\u53d8\uff0c\u4e5f\u662f\u57fa\u5e95\u8282\u75c5\u53d8<\/td><\/tr><tr><td>\u8111\u5e72\u8111\u708e<\/td><td>\u7ea6 15%<\/td><td>\u590d\u89c6\u3001\u5171\u6d4e\u5931\u8c03\u3001\u540e\u9057\u533a\u7efc\u5408\u5f81\uff08\u6253\u55dd\u3001\u5455\u5410\uff09<\/td><td>\u8111\u5e72\/\u5c0f\u8111 T2 \u75c5\u53d8<\/td><\/tr><tr><td>\u76ae\u8d28\u8111\u708e<\/td><td>\u7f55\u89c1<\/td><td>\u766b\u75eb\u53d1\u4f5c\u3001\u610f\u8bc6\u6a21\u7cca<\/td><td>\u76ae\u8d28 FLAIR \u4fe1\u53f7\u53d8\u5316<\/td><\/tr><tr><td>CRION<\/td><td>\u7f55\u89c1<\/td><td>\u6162\u6027\u590d\u53d1\u6027\u708e\u75c7\u89c6\u795e\u7ecf\u75c5\u53d8<\/td><td>\u6301\u7eed\u6027\u89c6\u795e\u7ecf\u635f\u4f24<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h1 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Diagnostik\"><\/span>\u8bca\u65ad<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">\u8bca\u65ad\u6807\u51c6\uff08Banwell et al\u3001, <em>\u67f3\u53f6\u5200\u795e\u7ecf\u5b66<\/em> 2023 \u5e74\uff09\u7684\u8981\u6c42\uff1a <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">(1) \u4f7f\u7528\u7ec6\u80de\u68c0\u6d4b\u6cd5\uff08CBA\uff09\u68c0\u6d4b\u8840\u6e05\u6216\u8111\u810a\u6db2\u4e2d\u7684 MOG-IgG<br>(2) \u9002\u5f53\u7684\u4e34\u5e8a\u8868\u578b<br>(3) \u6392\u9664\u5176\u4ed6\u8bca\u65ad\u3002.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7ec6\u80de\u514d\u75ab\u8367\u5149\u8bd5\u9a8c\uff08CBA\uff09<\/strong><br>\u4e0e\u81ea\u7136\u6298\u53e0\u3001\u819c\u7ed3\u5408\u7684 MOG\uff08\u8f6c\u67d3\u4eba MOG \u7684 HEK293 \u7ec6\u80de\uff09\uff1b\u68c0\u6d4b\u6784\u8c61\u4f9d\u8d56\u6027\u8868\u4f4d<\/li>\n\n\n\n<li><strong>\u9176\u8054\u514d\u75ab\u5438\u9644\u8bd5\u9a8c\u548c\u7ebf\u6027\/\u6761\u5e26\u5370\u8ff9<\/strong><br>\u5bf9 MOGAD \u4e0d\u53ef\u9760\uff0c\u56e0\u4e3a\u53ef\u8bc6\u522b\u7ebf\u6027\u8868\u4f4d<\/li>\n\n\n\n<li><strong>IgG \u4e9a\u7c7b<\/strong><br>\u4e3b\u8981\u4e3a IgG1\uff1b\u5076\u5c14\u4e3a IgG2\u3001IgG3\u3001IgG4\u3002IgG3 \u9633\u6027\u662f\u4e00\u4e2a\u8bca\u65ad\u9677\u9631\uff08Jarius 2024\uff09<\/li>\n\n\n\n<li><strong>\u6807\u9898\u52a8\u529b\u5b66<\/strong><br>\u6301\u7eed\u7684\u9ad8\u6ef4\u5ea6\u4e0e\u590d\u53d1\u98ce\u9669\u76f8\u5173\uff1b\u5728\u5355\u76f8\u75c5\u7a0b\u4e2d\uff0c\u6ef4\u5ea6\u5f80\u5f80\u4e0b\u964d<\/li>\n\n\n\n<li><strong>\u9152\u7c7b<\/strong><br>\u53ef\u80fd\u51fa\u73b0\u591a\u6838\u73b0\u8c61\uff1b\u5c11\u514b\u9686\u5e26\u7f55\u89c1\uff08&lt;10 %\uff09\uff0c\u9798\u5185 IgG \u5408\u6210\u7f55\u89c1<\/li>\n\n\n\n<li><strong>\u751f\u7269\u6807\u5fd7\u7269<\/strong><br>sNfL\uff08\u8840\u6e05\u795e\u7ecf\u4e1d\u8f7b\u94fe\uff09\u4f5c\u4e3a\u75be\u75c5\u6d3b\u52a8\u6027\u6807\u8bb0\u7269\uff1bsGFAP\uff08\u80f6\u8d28\u7ea4\u7ef4\u9178\u6027\u86cb\u767d\uff09\u4f5c\u4e3a\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u53d7\u7d2f\u7684\u6807\u8bb0\u7269<\/li>\n<\/ul>\n\n\n\n<h1 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Therapeutische_Strategien\"><\/span>\u6cbb\u7597\u7b56\u7565<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Akuttherapie_Schubbehandlung\"><\/span>\u6025\u6027\u6cbb\u7597\uff08\u590d\u53d1\u6cbb\u7597\uff09<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">MOGAD \u590d\u53d1\u7684\u6807\u51c6\u6cbb\u7597\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9ad8\u5242\u91cf <em>\u7532\u6cfc\u5c3c\u9f99<\/em> (HDMP)<\/strong><br>\u6bcf\u65e5\u9759\u8109\u6ce8\u5c04 1000 \u6beb\u514b\uff0c\u8fde\u7eed 5 \u5929 - \u4e00\u7ebf\u7528\u836f<\/li>\n\n\n\n<li><em><strong>\u8840\u6d46\u7f6e\u6362\u672f\/\u514d\u75ab\u5438\u9644\u672f<\/strong><\/em><br>\u5728 HDMP \u53cd\u5e94\u4e0d\u5145\u5206\u7684\u60c5\u51b5\u4e0b\uff1b\u6e05\u9664\u8840\u6d46\u4e2d\u7684 MOG-IgG\uff1b5-7 \u4e2a\u5468\u671f\uff08\u56de\u987e\u6027\u6570\u636e\u663e\u793a\uff0c\u7ea6 50-70% \u7684\u75c5\u4f8b\u5177\u6709\u7597\u6548\uff09<\/li>\n\n\n\n<li><strong><em>\u9759\u8109\u6ce8\u5c04\u514d\u75ab\u7403\u86cb\u767d<\/em> (IVIG)<\/strong><br>2\u514b\/\u5343\u514b\uff0c5\u5929\uff1b\u5bf9HDMP\u65e0\u53cd\u5e94\uff0c\u53ef\u4f5c\u4e3a\u8840\u6d46\u7f6e\u6362\u672f\u540e\u7684\u4e00\u79cd\u9009\u62e9\uff1b\u53ef\u80fd\u901a\u8fc7FcRn\u9971\u548c\u548cFc\u03b3R\u7ade\u4e89\u800c\u6709\u6548<\/li>\n\n\n\n<li><strong>\u9010\u6e10\u505c\u7528\u76ae\u8d28\u7c7b\u56fa\u9187<\/strong><br>\u5bf9 MOGAD\uff08\u9891\u7e41\u4f9d\u8d56\u7c7b\u56fa\u9187\uff09\u5c24\u4e3a\u91cd\u8981--\u5feb\u901f\u51cf\u91cf\u4f1a\u5f15\u53d1\u53cd\u5f39\u53d1\u4f5c<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Prophylaktische_Langzeittherapie\"><\/span>\u9884\u9632\u6027\u957f\u671f\u6cbb\u7597<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">(\u6807\u7b7e\u5916\uff0c\u65e0\u6388\u6743\u5236\u5242 - \u72b6\u6001 2026\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u957f\u671f\u6cbb\u7597\u7684\u9002\u5e94\u75c7\u662f\u56e0\u4eba\u800c\u5f02\u7684\uff0c\u5e76\u975e\u6240\u6709\u60a3\u8005\u90fd\u9700\u8981\u957f\u671f\u6cbb\u7597\u3002\u56e0\u7d20\uff1a\u590d\u53d1\u7387\u3001\u590d\u53d1\u4e25\u91cd\u7a0b\u5ea6\u3001\u6301\u7eed\u7684 MOG-IgG \u6ef4\u5ea6\u3001\u8868\u578b\u98ce\u9669\u56e0\u7d20\u3002.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><td><strong>\u7269\u8d28<\/strong><\/td><td><strong>\u4f5c\u7528\u673a\u5236<\/strong><\/td><td><strong>\u6570\u636e\u60c5\u51b5<\/strong><\/td><td><strong>\u8bc1\u636e\u7b49\u7ea7<\/strong><\/td><\/tr><\/thead><tbody><tr><td>\u786b\u5511\u560c\u5464<\/td><td>\u560c\u5464\u5408\u6210\u53d7\u963b\uff08TPMT \u4f9d\u8d56\u6027\uff09\uff1b\u6291\u5236 T \u548c B \u7ec6\u80de\u589e\u6b96<\/td><td>\u56de\u987e\u6027\u7814\u7a76\uff1b\u56fd\u5bb6 RCT \u6b63\u5728\u8fdb\u884c\u4e2d\uff08\u6cd5\u56fd\uff0cTOMATO \u7814\u7a76\uff09<\/td><td>IIb-III\uff08\u6807\u7b7e\u5916\uff09<\/td><\/tr><tr><td>\u9709\u915a\u9178\u916f\uff08MMF\uff09<\/td><td>\u5355\u78f7\u9178\u808c\u82f7\u8131\u6c22\u9176\u6291\u5236\u5242\uff1b\u6291\u5236\u6dcb\u5df4\u7ec6\u80de\u589e\u6b96<\/td><td>\u75c5\u4f8b\u7cfb\u5217\uff1b\u53ef\u80fd\u6709\u6548\uff0c\u9884\u9632\u590d\u53d1\u7684\u6548\u679c\u4f4e\u4e8e\u5229\u59a5\u6614\u5355\u6297<\/td><td>III\uff08\u6807\u7b7e\u5916\uff09<\/td><\/tr><tr><td>\u5229\u59a5\u6614\u5355\u6297<\/td><td>\u6297 CD20 \u2192 B \u7ec6\u80de\u8017\u7aed\uff1b\u6291\u5236 MOG-IgG \u751f\u6210<\/td><td>\u6700\u5927\u7684\u56de\u987e\u6027\u961f\u5217\uff1b\u6709\u6548\uff0c\u4f46\u5e76\u975e\u5bf9\u6240\u6709\u4eba\u90fd\u6709\u6548\uff1b\u611f\u67d3\u98ce\u9669\u589e\u52a0<\/td><td>IIb\uff08\u6807\u7b7e\u5916\uff09<\/td><\/tr><tr><td>\u6258\u897f\u73e0\u5355\u6297<\/td><td>\u6297 IL-6R\u03b1\uff08iv\uff09\uff1b\u963b\u65ad IL-6 \u4fe1\u53f7\u901a\u8def\uff08JAK\/STAT3\uff09\uff1b\u6291\u5236 Th17\/\u6d46\u7ec6\u80de<\/td><td>\u56de\u987e\u6027\u6570\u636e\u5448\u9633\u6027\uff1bNMOSD \u7684 RCT \u7ed3\u679c\u5448\u9633\u6027 (TANGO)<\/td><td>IIb\uff08\u6807\u7b7e\u5916\uff09<\/td><\/tr><tr><td>IVIG\uff08\u9759\u8109\u6ce8\u5c04\/\u76ae\u4e0b\u6ce8\u5c04\uff09<\/td><td>Fc \u53d7\u4f53\u9971\u548c\u5ea6\uff1bMOG-IgG \u4e2d\u548c\u4f5c\u7528\uff1bFcRn \u9971\u548c\u5ea6<\/td><td>\u79ef\u6781\u7684\u56de\u987e\u6027\u6570\u636e\uff1b\u53ef\u7528\u4e8e\u751f\u80b2\u3001\u6000\u5b55\u3001\u611f\u67d3<\/td><td>IIb\uff08\u6807\u7b7e\u5916\uff09<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Klinische_Studien_%E2%80%93_2024%E2%80%932026\"><\/span>\u4e34\u5e8a\u7814\u7a76 - 2024-2026<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">MOGAD \u7684\u51e0\u9879\u968f\u673a\u5b89\u6170\u5242\u5bf9\u7167 3 \u671f\u7814\u7a76\u6b63\u5728\u8fdb\u884c\u4e2d\uff0c\u9884\u8ba1\u5c06\u63d0\u4f9b I \u7c7b\u8bc1\u636e\uff1a<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><td><strong>\u7814\u7a76<\/strong><\/td><td><strong>\u7269\u8d28<\/strong><\/td><td><strong>\u673a\u5236<\/strong><\/td><td><strong>\u76ee\u6807\u7fa4\u4f53<\/strong><\/td><td><strong>\u73b0\u72b6<\/strong><\/td><\/tr><\/thead><tbody><tr><td>cosMOG<\/td><td>\u7f57\u624e\u5c3c\u73e0\u5355\u6297\uff08UCB7665\uff09<\/td><td>\u6297 FcRn IgG4-mAb\uff1a\u963b\u65ad IgG \u5faa\u73af \u2192 \u52a0\u901f IgG \u964d\u89e3\uff0c\u964d\u4f4e MOG IgG \u6ef4\u5ea6 ~50 %<\/td><td>\u6210\u4eba\uff08\u226518 \u5c81\uff09\uff0c\u590d\u53d1\uff0c\u22651 \u6b21\u590d\u53d1\/12 \u4e2a\u6708<\/td><td>\u7b2c 3 \u9636\u6bb5\uff0c\u56fd\u9645\u6027\uff1b\u9996\u6b21\u5f00\u5c55 MOGAD \u7b2c 3 \u9636\u6bb5\u7814\u7a76<\/td><\/tr><tr><td>METEOROID<\/td><td>\u8428\u66f2\u73e0\u5355\u6297\uff08\u6297IL-6R sc.\uff09<\/td><td>\u6297 IL-6R\uff08\u76ae\u4e0b\u6ce8\u5c04\uff09\uff1b\u6291\u5236 JAK\/STAT3 \u2192 Th17 \u5206\u5316\u3001B \u7ec6\u80de\u6210\u719f\u3001IgG \u751f\u6210<\/td><td>\u6210\u4eba + \u9752\u5c11\u5e74\uff08\u226512 \u5c81\uff09\uff1b\u590d\u53d1\uff0c\u4e4b\u524d\u22651 \u6b21\u590d\u53d1<\/td><td>\u7b2c 3 \u9636\u6bb5\uff0c\u56fd\u9645\uff0c\u8fdb\u884c\u4e2d<\/td><\/tr><tr><td>\u756a\u8304<\/td><td>\u786b\u5511\u560c\u5464<\/td><td>\u6291\u5236\u560c\u5464\u5408\u6210\uff1b\u5177\u6709\u5e7f\u6cdb\u7684\u514d\u75ab\u6291\u5236\u4f5c\u7528<\/td><td>\u6cd5\u56fd\u591a\u4e2d\u5fc3\u7814\u7a76\uff1b\u60a3\u6709 MOGAD \u7684\u6210\u5e74\u4eba<\/td><td>\u5168\u56fd\u6027 RCT\uff0c\u7b2c 3 \u9636\u6bb5<\/td><\/tr><tr><td>MOGwAI<\/td><td>\u672a\u8bf4\u660e\uff08\u89c2\u5bdf\u6027\uff09<\/td><td>\u751f\u7269\u6807\u5fd7\u7269\u7814\u7a76\uff1a\u9a8c\u8bc1 MOG-IgG \u6ef4\u5ea6\u3001sNfL\u3001sGFAP \u548c sCD83 \u4f5c\u4e3a\u75c5\u60c5\u53d1\u5c55\u6807\u5fd7\u7269\u7684\u6709\u6548\u6027<\/td><td>\u56fd\u9645\u7fa4\u7ec4\u7814\u7a76<\/td><td>\u6301\u7eed\u8fdb\u884c<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Neue_und_zukunftige_Therapiekonzepte\"><\/span>\u65b0\u7684\u548c\u672a\u6765\u7684\u6cbb\u7597\u7406\u5ff5<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u6839\u636e\u8fd1\u5e74\u6765\u7684\u5206\u5b50\u7814\u7a76\u7ed3\u679c\uff0c\u8ba8\u8bba\u4e86\u4ee5\u4e0b\u6cbb\u7597 MOGAD \u7684\u65b9\u6cd5\uff1a<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"BTK-Inhibitoren_Bruton-Tyrosin-Kinase\"><\/span>BTK \u6291\u5236\u5242\uff08\u5e03\u9c81\u987f\u916a\u6c28\u9178\u6fc0\u9176\uff09<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">BTK \u662f B \u7ec6\u80de\u53d7\u4f53\u4fe1\u53f7\u7ea7\u8054\uff08PI3K\/AKT\/MAPK\uff09\u7684\u6838\u5fc3\u6fc0\u9176\u3002. <strong><em>\u6258\u4e50\u66ff\u5c3c<\/em><\/strong> \u548c\u5176\u4ed6 BTK \u6291\u5236\u5242\u6b63\u5728\u8fdb\u884c MS \u548c NMOSD \u7814\u7a76\uff1bMOGAD \u7684\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u4e2d\u3002\u53e3\u670d\u5e94\u7528\u5c06\u662f\u4e00\u4e2a\u4f18\u52bf\u3002\u540c\u65f6\u6291\u5236 B \u7ec6\u80de\u6d3b\u5316\u548c\u9aa8\u9ad3\u7ec6\u80de\uff08\u5c0f\u80f6\u8d28\u7ec6\u80de-BTK\uff09\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Toleranzinduktion_MOG-Tolerisierung\"><\/span>\u8010\u53d7\u8bf1\u5bfc\uff08MOG \u8010\u53d7\uff09<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u6297\u539f\u7279\u5f02\u6027\u8010\u53d7\u8bf1\u5bfc\uff08\u5982\u901a\u8fc7 MOG \u80bd\u6216\u57fa\u4e8e\u7eb3\u7c73\u7c92\u5b50\u7684\u65b9\u6cd5\uff09\u662f\u4e00\u4e2a\u5f88\u6709\u524d\u666f\u7684\u6982\u5ff5\u3002\u8be5\u65b9\u6cd5 <strong><em>\u53e4\u5e0c-\u6770\u514b\u900a\u6148\u5584\u57fa\u91d1\u4f1a<\/em><\/strong> \u4fc3\u8fdb\u6cbb\u7597\u65b9\u6cd5\u7684\u7814\u7a76\u3002\u4f18\u52bf\uff1a\u65e0\u5168\u9762\u514d\u75ab\u6291\u5236\u3001, <strong>\u9009\u62e9\u6027\u6d88\u9664 MOG \u81ea\u8eab\u6d3b\u6027<\/strong>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Komplementinhibitoren\"><\/span>\u8865\u4f53\u6291\u5236\u5242<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u7531\u4e8e\u8865\u4f53\u6d3b\u5316\uff08C3a\u3001C5a\u3001MAC\uff09\u53ef\u5728 MOGAD \u75c5\u53d8\u4e2d\u68c0\u6d4b\u5230\uff0c\u56e0\u6b64\u5e94\u8be5 <strong><em>Eculizumab<\/em> (\u6297 C5\uff09<\/strong> \u6216 C3 \u6291\u5236\u5242\u7406\u8bba\u4e0a\u662f\u6709\u6548\u7684\u3002\u7136\u800c\uff0c\u7531\u4e8e\u5728 MOGAD \u4e2d\u5f62\u6210\u7684 MAC \u590d\u5408\u7269\uff08C5b-9\uff09\u8fdc\u5c11\u4e8e\u5728 NMOSD \u4e2d\u5f62\u6210\u7684 MAC \u590d\u5408\u7269\uff08\u5176\u4e2d <em>Eculizumab<\/em> \u6388\u6743\uff09\uff0c\u5176\u4e34\u5e8a\u610f\u4e49\u5c1a\u4e0d\u786e\u5b9a\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Anti-Neonatal-Fc-Rezeptor-Strategien\"><\/span>\u6297\u65b0\u751f\u513f Fc \u53d7\u4f53\u7b56\u7565<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u6b64\u5916 <em>\u7f57\u624e\u5c3c\u73e0\u5355\u6297<\/em> \u8fd8\u5c06 <strong><em>\u57c3\u6cd5\u52a0\u66ff\u83ab\u5fb7<\/em><\/strong> (IgG-Fc\u7247\u6bb5\u7ade\u4e89\u6027\u963b\u65adFcRn\uff09\u6cbb\u7597\u5176\u4ed6IgG\u4ecb\u5bfc\u7684\u75be\u75c5\u3002\u7531\u4e8e FcRn \u963b\u65ad\u7684\u75c5\u7406\u673a\u5236\u4f1a\u76f4\u63a5\u964d\u4f4e MOG-IgG \u6c34\u5e73\uff0c\u56e0\u6b64\u8fd9\u662f\u4e00\u79cd\u7279\u522b\u6709\u9488\u5bf9\u6027\u7684\u65b9\u6cd5\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Autologe_hamatopoetische_Stammzelltransplantation_aHSCT\"><\/span>\u81ea\u4f53\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\uff08aHSCT\uff09<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u5bf9\u4e8e\u4e25\u91cd\u7684\u96be\u6cbb\u6027\u75c5\u7a0b\uff0caHSCT \u662f\u4e00\u79cd\u6f5c\u5728\u7684\u6cbb\u7597\u6982\u5ff5\uff1a\u6df1\u5ea6\u514d\u75ab\u6d88\u878d\u548c\u514d\u75ab\u7cfb\u7edf\u91cd\u5efa\u53ef\u6d88\u9664\u81ea\u53cd\u5e94\u6027 T \u7ec6\u80de\u548c B \u7ec6\u80de\u514b\u9686\u3002\u6709\u5173 MOGAD \u7684\u6570\u636e\u975e\u5e38\u6709\u9650\uff1b\u53ea\u80fd\u5728\u4e13\u4e1a\u4e2d\u5fc3\u4f7f\u7528\u3002.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Biomarker_und_Verlaufsmonitoring\"><\/span>\u751f\u7269\u6807\u5fd7\u7269\u548c\u540e\u7eed\u76d1\u6d4b<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">\u57fa\u4e8e\u751f\u7269\u6807\u5fd7\u7269\u7684\u6cbb\u7597\u51b3\u7b56\u662f\u5f53\u524d\u7814\u7a76\u7684\u76ee\u6807\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>MOGgG \u6ef4\u5ea6\uff08\u8840\u6e05\uff09<\/strong><br>\u6301\u7eed\u5b58\u5728\u4e0e\u590d\u53d1\u98ce\u9669\u76f8\u5173\uff1b\u5728\u5355\u76f8\u75c5\u7a0b\u4e2d\uff0c\u6ef4\u5ea6\u5f80\u5f80\u81ea\u53d1\u4e0b\u964d\uff1b\u6cbb\u7597\u51b3\u5b9a\u662f\u5171\u540c\u51b3\u5b9a\u56e0\u7d20<\/li>\n\n\n\n<li><strong>\u8840\u6e05\u795e\u7ecf\u4e1d\u5149\uff08sNfL\uff09<\/strong><br>\u8f74\u7a81\u635f\u4f24\u6807\u5fd7\u7269\uff1b\u590d\u53d1\u65f6\u5347\u9ad8\uff1b\u4f5c\u4e3a\u6cbb\u7597\u53cd\u5e94\u6807\u5fd7\u7269\u6062\u590d\u6b63\u5e38<\/li>\n\n\n\n<li><strong>\u8840\u6e05 GFAP\uff08sGFAP\uff09<\/strong><br>\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u6d3b\u5316\uff1b\u5728 MOGAD \u4e2d\u4f4e\u4e8e\u5728 NMOSD \u4e2d\uff1b\u53ef\u63d0\u4f9b\u8865\u5145\u4fe1\u606f<\/li>\n\n\n\n<li><strong>sCD83<\/strong><br>\u65b0\u7684\u5019\u9009\u751f\u7269\u6807\u5fd7\u7269\uff08\u6b63\u5728\u9a8c\u8bc1\uff09\uff1b\u53ef\u80fd\u662f\u6811\u7a81\u72b6\u7ec6\u80de\u6d3b\u5316\u548c\u514d\u75ab\u6d3b\u52a8\u7684\u6807\u5fd7\u7269<\/li>\n\n\n\n<li><strong>\u8111\u810a\u6db2\u7ec6\u80de\u8ba1\u6570\u548c\u86cb\u767d\u8d28<\/strong><br>\u523a\u75db\u53d1\u4f5c\u65f6\u51fa\u73b0\u767d\u7ec6\u80de\u589e\u591a\uff1b\u6cbb\u7597\u540e\u6062\u590d\u6b63\u5e38<\/li>\n<\/ul>\n\n\n\n<h1 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Prognose_und_Besonderheiten\"><\/span>\u9884\u6d4b\u548c\u7279\u5199<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e0e AQP4+ NMOSD \u76f8\u6bd4\uff0cMOGAD \u503e\u5411\u4e8e\u663e\u793a\u51fa\u4e00\u79cd <strong>\u66f4\u6709\u5229\u7684\u9884\u6d4b<\/strong>, \u5c24\u5176\u662f\u5728 ON \u4e4b\u540e\uff0c\u89c6\u89c9\u6062\u590d\u4f1a\u66f4\u597d\u3002\u4e0d\u8fc7\uff0c\u4ee5\u4e0b\u51e0\u4e2a\u65b9\u9762\u4e5f\u5f88\u91cd\u8981\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5355\u76f8\u8fdb\u5c55<\/strong><br>\u7ea650%\u7684\u60a3\u8005\uff1b\u6ef4\u5ea6\u901a\u5e38\u81ea\u53d1\u4e0b\u964d\uff1b\u53ef\u80fd\u65e0\u9700\u957f\u671f\u6cbb\u7597<\/li>\n\n\n\n<li><strong>\u63a8\u529b\u5f0f\u524d\u8fdb<\/strong><br>\u7ea6 50%\uff1b\u66f4\u9ad8\u6ef4\u5ea6\u6301\u7eed\u5b58\u5728\uff1b\u53ef\u80fd\u7d2f\u79ef\u6b8b\u75be\uff0c\u4f46\u6bd4 NMOSD \u6162<\/li>\n\n\n\n<li><strong>\u65e0\u6e10\u8fdb\u5f0f\u8bfe\u7a0b<\/strong><br>\u4e0e\u591a\u53d1\u6027\u786c\u5316\u75c7\u4e0d\u540c\u7684\u662f\uff0c\u6ca1\u6709\u63cf\u8ff0\u8fc7\u65e0\u590d\u53d1\u7684\u6e10\u8fdb\u6027\u8fdb\u5c55<\/li>\n\n\n\n<li><strong>\u7c7b\u56fa\u9187\u654f\u611f\u6027\u548c\u7c7b\u56fa\u9187\u4f9d\u8d56\u6027<\/strong><br>\u7136\u800c\uff0c\u8bb8\u591a\u60a3\u8005\u5bf9\u76ae\u8d28\u7c7b\u56fa\u9187\u53cd\u5e94\u826f\u597d\uff1a\u5feb\u901f\u51cf\u91cf\u5f80\u5f80\u4f1a\u5f15\u53d1\u590d\u53d1<\/li>\n\n\n\n<li><strong>\u513f\u79d1\u7279\u8272<\/strong><br>ADEM \u662f\u513f\u7ae5\uff08\u5c0f\u4e8e 10 \u5c81\uff09\u6700\u5e38\u89c1\u7684\u521d\u59cb\u8868\u73b0\uff1b\u9884\u540e\u901a\u5e38\u826f\u597d\uff0c\u4f46\u8981\u6ce8\u610f\u590d\u53d1\u98ce\u9669<\/li>\n\n\n\n<li><strong>\u6000\u5b55\uff1a\u6570\u636e\u7a00\u8584<\/strong><br>\u6000\u5b55\u671f\u95f4\u590d\u53d1\u7684\u98ce\u9669\u4e00\u822c\u4e0d\u4f1a\u589e\u52a0\uff0c\u4f46\u4ea7\u540e\u53ef\u80fd\u662f\u4e00\u4e2a\u98ce\u9669\u56e0\u7d20\uff08\u7c7b\u4f3c\u4e8e\u591a\u53d1\u6027\u786c\u5316\u75c7\uff09\u3002<\/li>\n<\/ul>\n\n\n\n<h1 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Zusammenfassung_und_Ausblick\"><\/span>\u603b\u7ed3\u4e0e\u5c55\u671b<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">MOGAD \u662f\u4e00\u79cd\u72ec\u7acb\u7684\u3001\u6297\u4f53\u4ecb\u5bfc\u7684\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u4e3b\u8981\u7279\u5f81\u5982\u4e0b\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u548c\u9ad3\u9798\u5916\u90e8\u7684 MOG \u86cb\u767d\u662f\u76ee\u6807\u6297\u539f<\/li>\n\n\n\n<li>\u81f4\u75c5\u6027 MOG-IgG1 \u81ea\u8eab\u6297\u4f53\u901a\u8fc7\u4e24\u6761\u5e73\u884c\u7684\u6548\u5e94\u9014\u5f84\u635f\u4f24\u9ad3\u9798\uff1a\u8865\u4f53\u6fc0\u6d3b\uff08CDC\uff0c\u7ea6 50%\uff09\u548c Fc\u03b3R \u7ed3\u5408\uff08ADCC\/ADCP\uff0c\u7ea6 50%\uff09<\/li>\n\n\n\n<li>\u6b64\u5916\uff0c\u6297\u4f53\u8fd8\u80fd\u901a\u8fc7 Fc\u03b3R \u673a\u5236\u52a0\u5f3a T \u7ec6\u80de\u6d3b\u5316<\/li>\n\n\n\n<li>IL-6\/JAK\/STAT3 \u4fe1\u53f7\u901a\u8def\u4fc3\u8fdb Th17 \u5206\u5316\u548c\u6d46\u7ec6\u80de\u6210\u719f\uff0c\u662f\u4e00\u4e2a\u5173\u952e\u7684\u6cbb\u7597\u9776\u70b9<\/li>\n\n\n\n<li>\u76ee\u524d\u8fd8\u6ca1\u6709\u83b7\u5f97\u6279\u51c6\u7684\u7597\u6cd5\uff08\u622a\u81f3 2026 \u5e74 2 \u6708\uff09\uff1b\u9996\u6279 3 \u671f\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u4e2d\uff08cosMOG \u4e0e rozanolixizumab\uff0cMETEOROID \u4e0e satralizumab\uff09\u3002<\/li>\n\n\n\n<li>\u6cbb\u7597\u6b63\u671d\u7740\u9002\u5e94\u98ce\u9669\u3001\u57fa\u4e8e\u751f\u7269\u6807\u5fd7\u7269\u7684\u7b56\u7565\u65b9\u5411\u53d1\u5c55<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd1\u5e74\u6765\uff0c\u6700\u91cd\u8981\u7684\u7814\u7a76\u8fdb\u5c55\u662f\u7cbe\u786e\u89e3\u7801\u6548\u5e94\u673a\u5236\uff08\u8865\u4f53\u4e0e FcR \u901a\u8def\uff09\uff0c\u7814\u7a76\u5c0f\u7ec4\u5305\u62ec <strong>\u8fc8\u5c14\u3001\u9a6c\u5fb7\u3001\u5ddd\u4e0a\uff08\u6155\u5c3c\u9ed1\u5927\u5b66\uff09<\/strong>, \u8fd9\u5bf9\u6cbb\u7597\u65b9\u6cd5\u7684\u5f00\u53d1\u6709\u76f4\u63a5\u5f71\u54cd\uff1a\u6700\u4f73\u6cbb\u7597\u65b9\u6cd5\u5fc5\u987b\u9488\u5bf9 IgG \u7684\u4ea7\u751f\uff08\u6297 CD20\u3001FcRn \u6291\u5236\u5242\uff09\u4ee5\u53ca\u6548\u5e94\u673a\u5236\uff08\u8865\u4f53\u3001Fc\u03b3R\uff09\u548c Th17\/IL-6 \u8f74\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8010\u53d7\u6027\u8bf1\u5bfc\u7b56\u7565\u548c BTK \u6291\u5236\u5242\u4ee3\u8868\u4e86\u672a\u6765\u57fa\u4e8e\u673a\u7406\u7684\u6cbb\u7597\u539f\u5219\uff0c\u5f88\u53ef\u80fd\u5728\u672a\u6765\u51e0\u5e74\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Atherischer_Ole_%E2%80%93_Wirkstoffe_nach_Signalwegen_geordnet\"><\/span>\u7cbe\u6cb9--\u6839\u636e\u4fe1\u53f7\u901a\u8def\u5206\u7c7b\u7684\u6d3b\u6027\u6210\u5206<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u6d3b\u6027\u7269\u8d28\u53ef\u6839\u636e\u5176\u5728 MOGAD \u75c5\u7406\u751f\u7406\u5b66\u4e2d\u7684\u653b\u51fb\u70b9\u8fdb\u884c\u5206\u7c7b\u3002\u8fd9\u4e00\u70b9\u81f3\u5173\u91cd\u8981\uff0c\u56e0\u4e3a MOGAD \u6709\u4e09\u4e2a\u4e3b\u8f74\uff1a <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Th17\/IL-6<\/strong><\/li>\n\n\n\n<li><strong>\u8865\u4f53\u7cfb\u7edf\/\u8f6f\u9aa8\u7ec6\u80de\u4fdd\u62a4<\/strong><\/li>\n\n\n\n<li><strong>\u53bb\u9ad3\u9798\u5316\/\u8111\u7ec6\u80de\u5206\u5316<\/strong>.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Weihrauch_Boswellia_serrata_%E2%80%93_AKBA_und_Incensolacetat\"><\/span>\u4e73\u9999\uff08Boswellia serrata\uff09--AKBA \u548c\u918b\u9178incensol<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u636e BCP \u79f0\uff0c\u8fd9\u662f\u6700\u6709\u79d1\u5b66\u4f9d\u636e\u7684\u5019\u9009 MOGAD\uff0c\u5176\u6548\u679c\u8303\u56f4\u975e\u5e38\u5e7f\u6cdb\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>AKBA\uff083-O-\u4e59\u9170\u57fa-11-\u916e-\u03b2-\u4e73\u9999\u9178\uff09<\/strong> \u662f\u5176\u4e3b\u8981\u6d3b\u6027\u6210\u5206\u3002AKBA \u5177\u6709\u591a\u79cd\u751f\u7406\u4f5c\u7528\uff0c\u5305\u62ec\u6297\u611f\u67d3\u3001\u6297\u80bf\u7624\u548c\u6297\u6c27\u5316\u4f5c\u7528\uff0c\u4ee5\u53ca\u7ecf\u8bc1\u5b9e\u7684\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528\u3002\u5b83\u80fd\u4fc3\u8fdb\u795e\u7ecf\u4fee\u590d\u548c\u518d\u751f\uff0c\u9632\u6b62\u7f3a\u8840\u6027\u8111\u635f\u4f24\uff0c\u6291\u5236\u795e\u7ecf\u708e\u75c7\uff0c\u6539\u5584\u8bb0\u5fc6\u969c\u788d\u3002. <a href=\"https:\/\/www.ean.org\/research\/resources\/neurology-updates\/detail\/complement-dependent-and-independent-pathomechanisms-of-myelin-oligodendrocyte-glycoprotein-mog-abs-implications-for-therapeutic-strategies-in-mog-antibody-associated-disease-mogad\" target=\"_blank\" rel=\"noreferrer noopener\">\u6b27\u6d32\u795e\u7ecf\u75c5\u5b66\u5b66\u4f1a<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>AKBA \u53ef\u6291\u5236 STAT3<\/strong> AKBA\u5bf9Th17\u5206\u5316\u548c\u6d46\u7ec6\u80de\u6210\u719f\u5177\u6709\u5242\u91cf\u4f9d\u8d56\u6027\uff0c\u8fd9\u662f\u4e00\u79cd\u5173\u952e\u673a\u5236\uff0c\u56e0\u4e3aSTAT3\u662fIL-6\/JAK\u4fe1\u53f7\u901a\u8def\u7684\u4e3b\u8981\u6548\u5e94\u8f6c\u5f55\u56e0\u5b50\uff0c\u800cIL-6\/JAK\u4fe1\u53f7\u901a\u8def\u9a71\u52a8\u7740MOGAD\u4e2dTh17\u7684\u5206\u5316\u548c\u6d46\u7ec6\u80de\u7684\u6210\u719f\u3002\u6b64\u5916\uff0cAKBA \u5bf9 Nrf2\/HO-1 \u4fe1\u53f7\u901a\u8def\u7684\u6fc0\u6d3b\u4e3a\u51cf\u5c11\u6c27\u5316\u635f\u4f24\u3001\u9632\u6b62\u8131\u9ad3\u9798\u548c\u4fc3\u8fdb\u518d\u9ad3\u9798\u5316\u63d0\u4f9b\u4e86\u4e00\u4e2a\u65b9\u5411\u3002. <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.nanolett.9b02220\" target=\"_blank\" rel=\"noreferrer noopener\">ACS \u51fa\u7248\u7269<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">AKBA \u662f\u4e00\u79cd\u5206\u5b50\u5f00\u5173\uff0c\u5b83\u901a\u8fc7\u5bf9 5-LOX \u548c 15-LOX \u7684\u5f02\u6784\u8c03\u8282\u6765\u963b\u6b62\u767d\u4e09\u70ef\u7684\u5f62\u6210\uff0c\u4f46\u540c\u65f6\u53c8\u523a\u6fc0 SPM\uff08\u4e13\u4e1a\u4fc3\u6eb6\u89e3\u4ecb\u8d28\uff09\u7684\u4ea7\u751f\u3002\u8fd9\u5c31\u79ef\u6781\u5730\u5c06\u514d\u75ab\u53cd\u5e94\u5411\u4ee5\u4e0b\u65b9\u5411\u8f6c\u79fb <strong>\u6d88\u9664\u708e\u75c7<\/strong>, \u800c\u4e0d\u4ec5\u4ec5\u662f\u963b\u5c3c\u3002. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39133885\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u533b\u5b66\u6742\u5fd7<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u918b\u9178\u975b\u7ea2<\/strong> (\u4e73\u9999\uff08\u4e73\u9999\u7cbe\u6cb9\u7684\u6325\u53d1\u6027\u6210\u5206\uff0c\u53d1\u751f BHS\uff09\u53ef\u6fc0\u6d3b\u795e\u7ecf\u5143\u4e2d\u7684 TRPV3 \u901a\u9053\u4ee5\u53ca PPAR-\u03b3 - \u4e73\u9999\u6210\u5206\u53ef\u5728\u8bf1\u53d1\u708e\u75c7\u540e\u663e\u8457\u964d\u4f4e\u5927\u8111\u4e2d\u7684 IL-6\u3001TNF-\u03b1 \u548c GFAP\uff08\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u6d3b\u5316\u6807\u5fd7\uff09\u3002. <a href=\"https:\/\/www.neurology.org\/doi\/10.1212\/NXI.0000000000200293\" target=\"_blank\" rel=\"noreferrer noopener\">\u795e\u7ecf\u5b66<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u91cd\u8981\u8d28\u91cf\u8bf4\u660e\uff1a<\/strong> \u4e73\u9999\u4ea7\u54c1\u4e4b\u95f4\u7684\u8d28\u91cf\u5dee\u5f02\u5f88\u5927\uff0c\u6709\u4e9b\u4ea7\u54c1\uff08\u5982 H15 Ayurmedica\u00ae\uff09\u5728\u5206\u6790\u4e2d\u4ec5\u542b\u6709\u5fae\u91cf\u7684\u7279\u5f81\u6027\u4e73\u9999\u9178\uff080.31 \u6beb\u514b AKBA\uff09\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0cBOSWELLIASAN\u00ae\uff087.51 \u6beb\u514b\uff09\u548c Sallaki\u00ae Tablets\uff087.88 \u6beb\u514b\uff09\u7b49\u4ea7\u54c1\u5219\u663e\u793a\u51fa\u5927\u91cf\u7684 AKBA \u548c\u76f8\u5e94\u7684\u5f3a\u6548\u836f\u7406\u4f5c\u7528\u3002. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34358086\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u4e73\u9999\u7c7b\u6d88\u708e\u836f\u7684\u4e73\u9999\u9178\u542b\u91cf\u53ca\u76f8\u5173\u836f\u7406\u6d3b\u6027\u5206\u6790<\/a> \u548c <a href=\"https:\/\/www.frontiersin.org\/journals\/immunology\/articles\/10.3389\/fimmu.2025.1530977\/full\" target=\"_blank\" rel=\"noreferrer noopener\">\u524d\u6cbf<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">doTERRA \u4ea7\u54c1 <strong><a href=\"https:\/\/media.doterra.com\/us\/en\/pips\/frankincense-boswellic-acid-complex.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">\u4e73\u9999\u4e73\u9999\u9178\u590d\u5408\u7269<\/a><\/strong> \u542b 37.5 \u6beb\u514b AKBA*<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Therapeutisch_relevante_AKBA-Zieldosen\"><\/span>\u4e0e\u6cbb\u7597\u76f8\u5173\u7684 AKBA \u76ee\u6807\u5242\u91cf<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e34\u5e8a\u548c\u4e34\u5e8a\u524d\u7814\u7a76\u7684\u7ed3\u679c\u5982\u4e0b\uff1a<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u5e94\u7528\u76ee\u6807<\/th><th>AKBA \u6bcf\u65e5\u5242\u91cf<\/th><th>\u8d44\u6599\u6765\u6e90<\/th><\/tr><\/thead><tbody><tr><td>\u6d88\u708e\uff08\u4e00\u822c\uff09<\/td><td>100-200 \u6beb\u514b<\/td><td>\u4eba\u7c7b\u5173\u8282\/\u80a0\u9053\u7814\u7a76<\/td><\/tr><tr><td>NF-\u03baB \/ STAT3 \u6291\u5236\uff08\u795e\u7ecf\u708e\u75c7\uff09<\/td><td>200-400 \u6beb\u514b<\/td><td>\u52a8\u7269\u6a21\u578b\u3001\u7ec6\u80de\u57f9\u517b<\/td><\/tr><tr><td>\u6700\u4f73\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u6548\u679c\uff08\u5c4f\u969c\u901a\u8fc7\uff09<\/td><td>200-300 \u6beb\u514b<\/td><td>\u5b9e\u9a8c\u6570\u636e<\/td><\/tr><tr><td>\u8010\u53d7\u6027\u826f\u597d\u7684\u6bcf\u65e5\u6700\u9ad8\u5242\u91cf<\/td><td>400-600 \u6beb\u514b<\/td><td>\u8010\u53d7\u6027\u7814\u7a76<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Umrechnung_auf_375_mg_AKBA_jeKapsel\"><\/span>\u6362\u7b97\u6210\u6bcf\u7c92 37.5 \u6beb\u514b AKBA<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u76ee\u6807 AKBA \u65e5\u5242\u91cf<\/th><th>\u5355\u4f4d\/\u5929<\/th><th>\u5b9e\u7528\u65b9\u6848<\/th><\/tr><\/thead><tbody><tr><td>150 \u6beb\u514b<\/td><td>4 \u4e2a\u5355\u5143<\/td><td>\u65e9\u4e0a 2 \u6b21 + \u665a\u4e0a 2 \u6b21<\/td><\/tr><tr><td>200 \u6beb\u514b<\/td><td><strong>5-6 \u4e2a\u5355\u4f4d<\/strong><\/td><td>\u65e9\u4e0a 3 \u6b21 + \u665a\u4e0a 2-3 \u6b21<\/td><\/tr><tr><td>300 \u6beb\u514b<\/td><td>8 \u4e2a\u5355\u4f4d<\/td><td>\u65e9\u4e0a 4 \u6b21 + \u665a\u4e0a 4 \u6b21<\/td><\/tr><tr><td>400 \u6beb\u514b<\/td><td>10-11 \u4e2a\u5355\u4f4d<\/td><td>\u6bcf\u5929 3 \u00d7 3-4 \u4e2a\u5355\u4f4d<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u63a8\u8350\u53c2\u8d5b\uff1a<\/strong> <strong>\u6bcf\u5929 4 \u4e2a\u5355\u4f4d\uff08= 150 \u6beb\u514b AKBA\uff09<\/strong>, \u5206\u4e3a 2 \u4efd\u793c\u7269\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2 \u5468\u540e--\u5982\u679c\u8010\u53d7\u826f\u597d--\u589e\u81f3 6 \u4e2a\u5355\u4f4d\uff08= 225 \u6beb\u514b\uff09\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wichtige_Einnahmehinweise\"><\/span>\u91cd\u8981\u63a5\u6536\u8bf4\u660e<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u8102\u80aa\u81f3\u5173\u91cd\u8981\uff1a<\/strong> AKBA \u5177\u6709\u5f88\u5f3a\u7684\u4eb2\u8102\u6027\u3002 <strong>\u751f\u7269\u5229\u7528\u7387\u63d0\u9ad8 2-3 \u500d<\/strong>, \u5728\u8fdb\u98df\u6cb9\u817b\u98df\u7269\u65f6\u670d\u7528\u3002\u6a44\u6984\u6cb9\u3001\u9cc4\u68a8\u6216\u4e3b\u98df\u662f\u7406\u60f3\u7684\u9009\u62e9\u3002\u7a7a\u8179\u670d\u7528\u4f1a\u5927\u5927\u964d\u4f4e\u5438\u6536\u7387\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u65f6\u95f4\u5b89\u6392\uff1a<\/strong> AKBA \u7684\u534a\u8870\u671f\u7ea6\u4e3a 6 \u5c0f\u65f6\uff0c\u56e0\u6b64 <strong>\u6bcf\u65e5 2-3 \u5242<\/strong> \u8fd9\u6bd4\u5355\u6b21\u7528\u836f\u66f4\u6709\u610f\u4e49\uff0c\u56e0\u4e3a\u8fd9\u6837\u53ef\u4ee5\u4fdd\u6301\u5747\u5300\u7684\u836f\u6548\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u4e0e BCP \u7ed3\u5408\u4f7f\u7528\uff1a<\/strong> AKBA\uff08STAT3\/NF-\u03baB \u8f74\uff09\u548c BCP\uff08CB2\/Th17 \u8f74\uff09\u9488\u5bf9 MOGAD \u4e2d\u7684\u4e0d\u540c\u4fe1\u53f7\u901a\u8def\uff0c\u5e76\u53d1\u6325\u534f\u540c\u4f5c\u7528\u3002\u76ee\u524d\u5c1a\u672a\u53d1\u73b0\u836f\u7406\u4f5c\u7528\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u80c3\u8010\u53d7\u6027<\/strong> \u4e73\u9999\u7684\u8010\u53d7\u6027\u901a\u5e38\u5f88\u597d\u3002\u5242\u91cf\u8f83\u5927\u65f6\u5f88\u5c11\u4f1a\u51fa\u73b0\u8f7b\u5fae\u7684\u80c3\u90e8\u523a\u6fc0\u3002\u56e0\u6b64\uff0c\u4e00\u5b9a\u8981\u5728\u9910\u540e\u670d\u7528\uff0c\u6216\u5728\u5fc5\u8981\u65f6\u6682\u65f6\u51cf\u5c11\u5242\u91cf\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Schwarzer_Pfeffer_oral\"><\/span>\u9ed1\u80e1\u6912\uff08\u53e3\u670d\uff09<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u9ed1\u80e1\u6912\u6cb9\u4e2d\u7684\u4e3b\u8981\u6d3b\u6027\u6210\u5206 \u03b2-\u8336\u78b1\uff08BCP<em>\u848c<\/em>\uff09\u4f1a\u5bfc\u81f4\u708e\u75c7\u7ec6\u80de\u56e0\u5b50 IL-6\u3001TNF-\u03b1\u3001IL-17\u3001IFN-\u03b3 \u4ee5\u53ca Th17\uff08ROR-\u03b3t\uff09\u548c Th1\uff08T-bet\uff09\u8f6c\u5f55\u56e0\u5b50\u7684\u51cf\u5c11\uff0c\u540c\u65f6\u6297\u708e\u7ec6\u80de\u56e0\u5b50 TGF-\u03b21\u3001IL-10\u3001IL-4 \u4ee5\u53ca Th2\uff08GATA3\uff09\u548c Treg\uff08Foxp3\uff09\u8f6c\u5f55\u56e0\u5b50\u7684\u663e\u8457\u589e\u52a0\u3002\u8fd9\u4e9b\u4f5c\u7528\u4e0e CB2 \u53d7\u4f53\u7684\u6fc0\u6d3b\u5bc6\u5207\u76f8\u5173\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CB2 \u53d7\u4f53\u548c\u518d\u9ad3\u9798\u5316\u5728\u673a\u7406\u4e0a\u6709\u76f4\u63a5\u8054\u7cfb\uff1aCB2 \u6fc0\u52a8\u53ef\u4fc3\u8fdb OPC \u7684\u6210\u719f--\u65b0\u4e00\u4ee3 CB2 \u6fc0\u52a8\u5242\uff08Yhhu4952\uff09\u53ef\u663e\u8457\u589e\u52a0\u9ad3\u9798\u78b1\u6027\u86cb\u767d\uff08MBP\uff09\u7684\u8868\u8fbe\u548c\u80fc\u80dd\u4f53\u4e2d\u6210\u719f\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u7684\u6bd4\u4f8b\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u9ed1\u80e1\u6912\u7684\u7528\u91cf\uff1a20 ...200 mg\/d - \u76f8\u5f53\u4e8e 20 tr.\/d - \u56e0\u6b64\uff0c\u6700\u597d\u6bcf 8 \u5c0f\u65f6\u670d\u7528 7 trp.\u4f5c\u4e3a\u4eb2\u8102\u5242\u4e0e\u9ad8\u8102\u80aa\u98df\u7269\/\u996e\u6599\u4e00\u8d77\u670d\u7528\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Schwarzer_Pfeffer_Inhalation\"><\/span>\u9ed1\u80e1\u6912\uff08\u5438\u5165\uff09<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u7528\u91cf\uff1a\u767d\u5929\u6bcf 4 \u5c0f\u65f6\u5438\u5165 3 \u6ef4\uff08\u534a\u8870\u671f\u4e3a 2-4 \u5c0f\u65f6\uff09\u5230\u52a0\u70ed\u6269\u9999\u5668\u7684\u6db2\u4f53\u57ab\u4e0a\uff0c\u6301\u7eed 20 \u5206\u949f\uff0c\u6bcf\u6b21\u6df1\u547c\u5438\u540e\u5c4f\u4f4f\u547c\u5438\u7ea6 5-8 \u79d2\u949f\uff0c\u665a\u4e0a\u8ba9\u6269\u9999\u5668\u5728\u623f\u95f4\u91cc\u8fd0\u8f6c\uff0c\u4e0d\u8981\u76f4\u63a5\u5438\u5165\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u9ed1\u80e1\u6912\u53ef\u80fd\u4f1a\u4ea7\u751f\u523a\u6fc0\u4f5c\u7528\uff0c\u5f71\u54cd\u7761\u7720\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u8bf7\u52ff\u5728\u591c\u95f4\u4f7f\u7528\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5982\u679c\u547c\u5438\u9053\u53d7\u5230\u523a\u6fc0\uff08\u5e72\u71e5\uff09\u6216\u51fa\u73b0\u5934\u75db\uff1a\u51cf\u5c11\u5242\u91cf\u6216\u5ef6\u957f\u95f4\u9694\u65f6\u95f4\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Copaiba-Ol_oral_%E2%80%93_NUR_doTERRA\"><\/span>Copaiba \u6cb9\uff08\u53e3\u670d\uff09 - ONLY doTERRA<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">52.6 % BCP - \u76f8\u5f53\u4e8e\u6bcf\u6ef4 14.7 \u6beb\u514b BCP - \u7531\u4e8e BCP \u5177\u6709\u4eb2\u8102\u6027\uff0c\u8bf7\u52a1\u5fc5\u4e0e\u9ad8\u8102\u80aa\u98df\u7269\/\u996e\u6599\u4e00\u8d77\u670d\u7528\uff01<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6839\u636e\u4e34\u5e8a\u5b89\u5168\u6027\u7814\u7a76\uff0c\u5f97\u51fa\u4ee5\u4e0b\u57fa\u4e8e\u4f53\u91cd\u7684\u7528\u91cf\u5efa\u8bae\uff1a<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"MOGAD-spezifische_Dosierungstabelle_doTERRA_Copaiba_525_BCP\"><\/span>MOGAD \u4e13\u7528\u5242\u91cf\u8868\uff08doTERRA Copaiba 52.5 % BCP\uff09<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u4f53\u91cd<\/th><th><strong>\u73af\u5883\u4fdd\u62a4<\/strong> (0.4 \u6beb\u514b\/\u5343\u514b)<\/th><th><strong>\u4e3b\u52a8\u63a8\u529b<\/strong> (1.0 \u6beb\u514b\/\u5343\u514b)<\/th><th><strong>\u5f3a\u5316\u6cbb\u7597<\/strong> (1.5 \u6beb\u514b\/\u5343\u514b)<\/th><\/tr><\/thead><tbody><tr><td><strong>50 \u5343\u514b<\/strong><\/td><td>20 \u6beb\u514b = <strong>1-2 \u6ef4<\/strong><\/td><td>50 \u6beb\u514b = <strong>3-4 \u6ef4<\/strong><\/td><td>75 \u6beb\u514b = <strong>5 \u6ef4<\/strong><\/td><\/tr><tr><td><strong>60 \u516c\u65a4<\/strong><\/td><td>24 \u6beb\u514b = <strong>2 \u6ef4<\/strong><\/td><td>60 \u6beb\u514b = <strong>4 \u6ef4<\/strong><\/td><td>90 \u6beb\u514b = <strong>6 \u6ef4<\/strong><\/td><\/tr><tr><td><strong>70 \u516c\u65a4<\/strong><\/td><td>28 \u6beb\u514b = <strong>2 \u6ef4<\/strong><\/td><td>70 \u6beb\u514b = <strong>5 \u6ef4<\/strong><\/td><td>105 \u6beb\u514b = <strong>7 \u6ef4<\/strong><\/td><\/tr><tr><td><strong>80 \u516c\u65a4<\/strong><\/td><td>32 \u6beb\u514b = <strong>2 \u6ef4<\/strong><\/td><td>80 \u6beb\u514b = <strong>5-6 \u6ef4<\/strong><\/td><td>120 \u6beb\u514b = <strong>8 \u6ef4<\/strong><\/td><\/tr><tr><td><strong>90 \u516c\u65a4<\/strong><\/td><td>36 \u6beb\u514b = <strong>2-3 \u6ef4<\/strong><\/td><td>90 \u6beb\u514b = <strong>6 \u6ef4<\/strong><\/td><td>135 \u6beb\u514b = <strong>9\u6ef4<\/strong><\/td><\/tr><tr><td><strong>100 \u516c\u65a4<\/strong><\/td><td>40 \u6beb\u514b = <strong>3 \u6ef4<\/strong><\/td><td>100 \u6beb\u514b = <strong>7 \u6ef4<\/strong><\/td><td>150 \u6beb\u514b = <strong>10 \u6ef4<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"MOGAD-Phasen-adaptierte_Dosierung\"><\/span>MOGAD \u9636\u6bb5\u6027\u8c03\u6574\u5242\u91cf<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Phase_1_Akuter_Schub_erste_2%E2%80%934_Wochen\"><\/span><strong>\u7b2c 1 \u9636\u6bb5\uff1a\u6025\u6027\u53d1\u4f5c\uff08\u6700\u521d 2-4 \u5468\uff09<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u76ee\u6807\uff1a<\/strong> \u79ef\u6781\u6291\u5236 Th17\uff0c\u964d\u4f4e IL-6<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7528\u91cf\uff1a<\/strong> \u6bcf\u5929 1.0-1.5 \u6beb\u514b\/\u5343\u514b<\/li>\n\n\n\n<li><strong>\u5206\u914d\uff1a<\/strong> \u6bcf\u5929 3 \u6b21\uff08\u6700\u9002\u5408\u6301\u7eed\u6fc0\u6d3b CB2 \u53d7\u4f53\uff09<\/li>\n\n\n\n<li><strong>\u4f8b\u5982 70 \u516c\u65a4\uff1a<\/strong> \u6bcf\u5929 5-7 \u6ef4\uff0c\u4ee5 2+2+3 \u6ef4\u7684\u5f62\u5f0f\u5206\u53d1<\/li>\n\n\n\n<li><strong>\u7ec4\u5408\uff1a<\/strong> AKBA\uff08200-300 \u6beb\u514b\/\u5929\uff0c\u7528\u4e8e\u6291\u5236 STAT3\uff09+ \u5927\u5242\u91cf\u53ef\u7684\u677e\uff08\u6807\u51c6\u5242\u91cf\uff09<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Phase_2_Schubremission_Erhaltung_langfristig\"><\/span><strong>\u7b2c\u4e8c\u9636\u6bb5\uff1a\u590d\u53d1\u7f13\u89e3\/\u7ef4\u6301\uff08\u957f\u671f\uff09<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u76ee\u6807\uff1a<\/strong> \u9884\u9632\u590d\u53d1\uff0c\u6301\u7eed\u7684\u6297\u708e\u57fa\u8c03<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7528\u91cf\uff1a<\/strong> \u6bcf\u5929 0.4-0.7 \u6beb\u514b\/\u5343\u514b<\/li>\n\n\n\n<li><strong>\u5206\u914d\uff1a<\/strong> \u6bcf\u5929 2 \u6b21<\/li>\n\n\n\n<li><strong>\u4f8b\u5982 70 \u516c\u65a4\uff1a<\/strong> \u6bcf\u5929 2-3 \u6ef4\uff0c\u4ee5 1+2 \u6216 2+2 \u7684\u5f62\u5f0f\u5206\u53d1<\/li>\n\n\n\n<li><strong>\u7ec4\u5408\uff1a<\/strong> \u53ef\u9009 AKBA\uff08150 \u6beb\u514b\/\u5929<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Phase_3_Monophasischer_Verlauf_Titer_fallend\"><\/span><strong>\u7b2c 3 \u9636\u6bb5\uff1a\u5355\u76f8\u7597\u7a0b\uff08\u6ef4\u5ea6\u4e0b\u964d\uff09<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u76ee\u6807\uff1a<\/strong> \u795e\u7ecf\u4fdd\u62a4\u3001\u518d\u9ad3\u9798\u5316<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u7528\u91cf\uff1a<\/strong> \u6bcf\u5929 0.2-0.4 \u6beb\u514b\/\u5343\u514b<\/li>\n\n\n\n<li><strong>\u5206\u914d\uff1a<\/strong> \u6bcf\u5929 1-2 \u6b21<\/li>\n\n\n\n<li><strong>\u4f8b\u5982 70 \u516c\u65a4\uff1a<\/strong> \u6bcf\u5929 1-2 \u6ef4<\/li>\n\n\n\n<li><strong>\u53ef\u80fd\u7684\u5e73\u8861<\/strong> \u8840\u6e05\u9634\u6027\u7a33\u5b9a 6-12 \u4e2a\u6708\u540e<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Quellen\"><\/span>\u8d44\u6599\u6765\u6e90<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u6bd2\u7406\u5b66\uff08700 \u6beb\u514b\/\u5343\u514b\u65e0\u89c2\u6d4b\u4e0d\u826f\u6548\u5e94\u6c34\u5e73\uff09<\/strong><br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27358239\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/27358239\/<\/a><\/li>\n\n\n\n<li><strong>EAE \u6a21\u578b\uff082.5-5 \u6beb\u514b\/\u5343\u514b\u6709\u6548\u5242\u91cf\uff09<\/strong><br><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10377147\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10377147\/<\/a><\/li>\n\n\n\n<li><strong>\u4eba\u4f53\u7814\u7a76\uff08100 \u6beb\u514b\u5b89\u5168\uff09<\/strong><br><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9104399\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9104399\/<\/a><\/li>\n\n\n\n<li><strong>\u4e34\u5e8a\u7814\u7a76\uff08126 \u6beb\u514b\/\u5929\u6709\u6548\uff09<\/strong><br><a href=\"https:\/\/accurateclinic.com\/accurate-education-terpenes-caryophyllene\/\" target=\"_blank\" rel=\"noopener\">https:\/\/accurateclinic.com\/accurate-education-terpenes-caryophyllene\/<\/a><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Copaiba-Ol_Inhalation\"><\/span>\u79d1\u5e15\u5df4\u6cb9\uff08\u5438\u5165\uff09<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u9664\u4e86\u9ed1\u80e1\u6912\u7684 BCP \u6700\u9ad8\u53ef\u8fbe 38%\uff0c\u79d1\u5df4\u5df4\u6cb9\u7684 BCP \u6700\u9ad8\u53ef\u8fbe 87%\uff0c\u836f\u6548\u66f4\u5f3a\uff0c\u56e0\u6b64\u662f\u5438\u5165\u7684\u6700\u4f73\u9009\u62e9\u3002.<br>\u6269\u6563\u5668\u901a\u5e38\u4f7f\u7528\u51b7\u8d85\u58f0\u6ce2\uff08US\uff09\u96fe\u5316\u3002\u7136\u800c\uff0cBCP \u53ea\u80fd\u5728 130 \u00b0C \u5de6\u53f3\u7684\u6e29\u5ea6\u4e0b\u6c7d\u5316\uff0c\u5728 180 \u00b0C \u4ee5\u4e0a\u7684\u6e29\u5ea6\u4e0b\u4f1a\u71c3\u70e7\u3002\u56e0\u6b64\uff0c\u5fc5\u987b\u4f7f\u7528\u53ef\u52a0\u70ed\u3001\u6e29\u5ea6\u53ef\u63a7\u7684\u6269\u6563\u5668\uff08\u4f8b\u5982. <a href=\"https:\/\/storz-bickel.com\" target=\"_blank\" rel=\"noreferrer noopener\">\u7ecf\u5178\u706b\u5c71\u3001\u6df7\u5408\u706b\u5c71\u6216 Mighty+<\/a>)\u7684\u4ef7\u683c\u6bb5\u7ea6\u4e3a 270 - 415 \u6b27\u5143\uff0c\u6e29\u5ea6\u5e94\u5c3d\u53ef\u80fd\u7cbe\u786e\u5730\u8bbe\u7f6e\u4e3a 160 \u00b0C\uff08\u7528\u7ea2\u5916\u6e29\u5ea6\u8ba1\u68c0\u67e5\uff09\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u542b\u6709 69 % BCP \u7684\u79d1\u5e15\u5df4\u6cb9\uff08doTERRA\uff09\u7684\u5efa\u8bae\u7528\u91cf - 1 \u6ef4\u542b\u6709 18.6 \u6beb\u514b BCP\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">BCP \u7684\u534a\u8870\u671f\u4e3a 2-4 \u5c0f\u65f6\u3002\u4e3a\u4e86\u4f7f\u6d3b\u6027\u6210\u5206\u8fbe\u5230\u5c3d\u53ef\u80fd\u7a33\u5b9a\u7684\u6c34\u5e73\uff0c\u5e94\u6309\u4e0a\u8ff0\u65b9\u6cd5\u6bcf 4 \u5c0f\u65f6\u5438\u5165 4 \u6ef4\uff08\u76f8\u5f53\u4e8e\u7ea6 200 \u6beb\u514b BCP\uff09\u3002\u591c\u95f4\u53ef\u5c06\u6269\u9999\u5668\u653e\u5728\u5e8a\u8fb9\u3002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Zieldosen_und_benotigte_Tropfenzahl\"><\/span>\u76ee\u6807\u5242\u91cf\u548c\u6240\u9700\u6ef4\u6570<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>BCP \u76ee\u6807\u5242\u91cf<\/th><th>\u79d1\u5e15\u5df4\u6cb9\u6ef4<\/th><th>\u6cb9\u8102\u603b\u91cf\uff08\u6beb\u514b\uff09<\/th><\/tr><\/thead><tbody><tr><td>20 \u6beb\u514b BCP\uff08\u8d77\u59cb\u5242\u91cf\uff09<\/td><td><strong>~1 \u6ef4<\/strong><\/td><td>~29 \u6beb\u514b<\/td><\/tr><tr><td>50 \u6beb\u514b BCP<\/td><td><strong>~3 \u6ef4<\/strong><\/td><td>~72 \u6beb\u514b<\/td><\/tr><tr><td>100 \u6beb\u514b BCP\uff08\u6cbb\u7597\u7528\uff09<\/td><td><strong>~5-6 \u6ef4<\/strong><\/td><td>~145 \u6beb\u514b<\/td><\/tr><tr><td>120 \u6beb\u514b BCP\uff08\u6bcf\u65e5\u6700\u9ad8\u5242\u91cf\uff09<\/td><td><strong>~6-7 \u6ef4<\/strong><\/td><td>~174 \u6beb\u514b<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u76ee\u6807\u5438\u5165\u5f0f BCP<\/th><th>\u6db2\u4f53\u57ab\u4e0a\u7684\u6cb9\u91cf<\/th><th>\u6c34\u6ef4<\/th><\/tr><\/thead><tbody><tr><td>~20 \u6beb\u514b BCP \u5438\u5165<\/td><td>~40\u6beb\u514b\u6cb9\uff08~78\u6beb\u514b\/0.69\uff09<\/td><td><strong>2-3 \u6ef4<\/strong><\/td><\/tr><tr><td>~50 \u6beb\u514b BCP \u5438\u5165<\/td><td>~100 \u6beb\u514b\u6cb9<\/td><td><strong>4-5 \u6ef4<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Synergistische_MOGAD-Strategie_Multi-Target\"><\/span>\u534f\u540c MOGAD \u6218\u7565\uff08\u591a\u76ee\u6807\uff09<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u7531\u4e8e MOGAD \u6709\u4e09\u79cd\u75c5\u7406\u673a\u5236\uff0c\u56e0\u6b64\u8fd9\u79cd\u4ee5\u8bc1\u636e\u4e3a\u57fa\u7840\u7684\u7ec4\u5408\u4ea7\u751f\u4e86\u7ed3\u679c\uff1a<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u6d3b\u6027\u6210\u5206<\/th><th>\u5242\u91cf<\/th><th>\u4fe1\u53f7\u8def\u5f84<\/th><th>MOGAD \u76f8\u5173\u6027<\/th><\/tr><\/thead><tbody><tr><td><strong>BCP \uff08\u53e3\u670d\uff09<\/strong><\/td><td>0.4-1.5 \u6beb\u514b\/\u5343\u514b<\/td><td>CB2 \u2192 Th17\u2193\u3001IL-6\u2193\u3001Nrf2\/HO-1\u2191<\/td><td>\u2605\u2605\u2605\u2605\u2605<\/td><\/tr><tr><td><strong>AKBA\uff08\u53e3\u670d\uff09<\/strong><\/td><td>200-400 \u6beb\u514b\/\u5929<\/td><td>STAT3\u2193\u3001NF-\u03baB\u2193\u30015-LOX\u2193<\/td><td>\u2605\u2605\u2605\u2605\u2605<\/td><\/tr><tr><td><strong>BCP \uff08\u5438\u5165\uff0c160 \u00b0C\uff09<\/strong><\/td><td>2-3\u6ef4\uff0c2\u6b21\/\u5929<\/td><td>\u8fb9\u7f18\u578b\uff0c\u5feb\u901f\u6e17\u900f\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf<\/td><td>\u2605\u2605\u2605<\/td><\/tr><tr><td><strong>\u4e73\u9999\u7cbe\u6cb9\uff08\u5438\u5165\uff09<\/strong><\/td><td>3-4 \u6ef4\uff0c2\u00d7\/\u5929<\/td><td>Incensol acetate \u2192 TRPV3\u3001PPAR-\u03b3<\/td><td>\u2605\u2605\u2605<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd9\u4e00\u56db\u5927\u652f\u67f1\u6218\u7565\u6d89\u53ca<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Th17\/IL-6<\/strong> (\u53e3\u670d BCP + AKBA\uff09<\/li>\n\n\n\n<li><strong>STAT3<\/strong> (AKBA)<\/li>\n\n\n\n<li><strong>\u4fdd\u62a4\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de<\/strong> (BCP Nrf2 \u6fc0\u6d3b)<\/li>\n\n\n\n<li><strong>\u80a2\u4f53\u8c03\u5236<\/strong> \u5438\u5165<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wichtige_MOGAD-spezifische_Hinweise\"><\/span>\u9488\u5bf9 MOGAD \u7684\u91cd\u8981\u4fe1\u606f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>\u65e0\u5355\u4e00\u7597\u6cd5<\/strong> - BCP\/AKBA \u662f <strong>\u5e38\u89c4\u7597\u6cd5\u7684\u9644\u52a0\u7597\u6cd5<\/strong><br>(\u53ef\u7684\u677e\u6025\u6027\u6cbb\u7597\uff0c\u5fc5\u8981\u65f6\u5229\u59a5\u6614\u5355\u6297\/MMF\/IVIG\u9884\u9632\u6027\u6cbb\u7597\uff09--\u7edd\u4e0d\u53ef\u66ff\u4ee3\u6cbb\u7597<\/li>\n\n\n\n<li><strong>\u751f\u7269\u6807\u8bb0\u76d1\u6d4b\uff1a<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u6bcf 3-6 \u4e2a\u6708\u8fdb\u884c\u4e00\u6b21 MOGgG \u6ef4\u5ea6\u68c0\u6d4b<\/li>\n\n\n\n<li>sNfL\uff08\u795e\u7ecf\u4e1d\u5149\uff09\u4f5c\u4e3a\u6d3b\u6027\u6807\u8bb0<\/li>\n\n\n\n<li>\u5982\u679c\u6ef4\u5ea6\u6301\u7eed\u4e0b\u964d\uff0c\u8003\u8651\u51cf\u5c11\u5242\u91cf<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u89c2\u5bdf\u63a8\u529b\u89e6\u53d1\u5668<\/strong> - \u611f\u67d3\u662f\u4e3b\u8981\u8bf1\u56e0<br>\u611f\u67d3\u65f6\uff0c\u5fc5\u8981\u65f6\u53ef\u6295\u836f <strong>\u6682\u65f6\u589e\u81f3 1.5 \u6beb\u514b\/\u5343\u514b<\/strong> \uff08\u9884\u9632\u6027\uff09<\/li>\n\n\n\n<li><strong>\u79d1\u5e15\u4f9d\u5df4\u7684\u809d\u810f\u503c<\/strong> - \u5982\u679c &gt;1 \u6beb\u514b\/\u5343\u514b\uff0c\u6301\u7eed &gt;3 \u4e2a\u6708<br>\u6bcf 3 \u4e2a\u6708\u68c0\u67e5\u4e00\u6b21 ALT\/AST<\/li>\n\n\n\n<li><strong>\u9ed1\u80e1\u6912\u66ff\u4ee3\u54c1<\/strong> - \u5173\u4e8e\u79d1\u5e15\u5df4\uff1a\u9ed1\u80e1\u6912\u6cb9\uff0825-38 % BCP\uff09<br>\u7136\u540e\u8ba1\u7b97\u6ef4\u6570 \u00d7 2<\/li>\n<\/ol>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%CE%B1-Asaron_Kalmus-Ol_Acorus_calamus_%E2%80%93_direkt_oligodendrozytenprotektiv\"><\/span>\u03b1-Asarone \uff08\u83d6\u84b2\u6cb9\u3001, <em>\u6c34\u83d6\u84b2<\/em>) - \u76f4\u63a5\u4fdd\u62a4\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e3a\u6570\u4e0d\u591a\u7684\u6d3b\u6027\u6210\u5206\u4e4b\u4e00 <strong>\u76f4\u63a5\u518d\u9ad3\u9798\u5316\u6548\u5e94<\/strong> \u662f <em><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37146420\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u03b1-Asaron<\/a><\/strong><\/em>. .\u5b83\u901a\u8fc7\u4e0a\u8c03\u548c\u6fc0\u6d3b\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u4e2d\u7684 PPAR-\u03b3 \u6765\u6539\u5584\u7f3a\u6c27\u7f3a\u8840\u540e\u56e0\u6210\u719f\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u4e27\u5931\u800c\u5bfc\u81f4\u7684\u9ad3\u9798\u53d1\u80b2\u4e0d\u826f\u3002\u8fd9\u589e\u52a0\u4e86\u8c37\u6c28\u9178\u8f6c\u8fd0\u4f53 GLT-1 \u7684\u8868\u8fbe\uff0c\u6e05\u9664\u4e86\u7ec6\u80de\u5916\u7a7a\u95f4\u4e2d\u8fc7\u591a\u7684\u8c37\u6c28\u9178\uff0c\u5426\u5219\u8fd9\u4e9b\u8c37\u6c28\u9178\u4f1a\u5bfc\u81f4\u8c37\u6c28\u9178\u4ecb\u5bfc\u7684 OPC \u5174\u594b\u6bd2\u6027\uff0c\u6291\u5236\u5176\u5206\u5316\u5e76\u8bf1\u5bfc\u7ec6\u80de\u6b7b\u4ea1\u3002. <a href=\"https:\/\/www.klinikum.uni-heidelberg.de\/neurologische-klinik\/neurologie-und-poliklinik\/forschung\/neuroimmunology\/ag-molekulare-neuroimmunologie\/mog-enzephalomyelitis\" target=\"_blank\" rel=\"noreferrer noopener\">\u6d77\u5fb7\u5821\u5927\u5b66\u533b\u9662<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u795e\u7ecf\u75c5\u5b66\u4e2d\u7684 PPARy - <a href=\"https:\/\/www.frontiersin.org\/journals\/neuroscience\/articles\/10.3389\/fnins.2022.1060515\/pdf\" target=\"_blank\" rel=\"noreferrer noopener\">\u524d\u6cbf\u300b\u7f16\u8f91\u90e8 2022<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u8bf7\u6ce8\u610f\uff1a<\/strong> \u6839\u636e\u4ea7\u5730\u4e0d\u540c\uff0c\u83d6\u84b2\u6cb9\u4e2d\u542b\u6709\u4e0d\u540c\u91cf\u7684\u03b2-asarone\uff0c\u5b83\u88ab\u5f52\u7c7b\u4e3a\u81f4\u7a81\u53d8\u7269\u8d28\u3002\u53ea\u6709 <strong>\u4e0d\u542b \u03b2-Asarone \u7684\u54c1\u8d28<\/strong> (Acorus calamus var. americanus\uff09\u3002.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6839\u636e\u76ee\u524d\u7684\u72b6\u51b5\uff0802.2026\uff09\uff0c\u6ca1\u6709\u63d0\u4f9b\u5e02\u573a\u4f9b\u5e94\u60c5\u51b5\u3002.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Geraniumol_Pelargonium_graveolens_%E2%80%93_Neuroinflammation_und_NO\"><\/span>\u5929\u7afa\u8475\u6cb9 (<em>\u5929\u7afa\u8475<\/em>\u795e\u7ecf\u53d1\u708e\u548c NO<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7922935\/\" rel=\"nofollow noopener\" target=\"_blank\">\u5929\u7afa\u8475\u6cb9<\/a> \u53ef\u80fd\u5bf9\u795e\u7ecf\u708e\u75c7\u662f\u75c5\u7406\u751f\u7406\u5b66\u4e00\u90e8\u5206\u7684\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u6709\u7528\u3002.<br>\u4e3b\u8981\u6d3b\u6027\u6210\u5206 <em>\u9999\u8305\u9187<\/em> \u5728\u8f83\u9ad8\u6d53\u5ea6\u4e0b\uff0c\u8fd9\u4e9b\u6210\u5206\u5bf9 NO \u7684\u4ea7\u751f\u6709\u5f88\u597d\u7684\u6291\u5236\u4f5c\u7528\uff0c\u56e0\u6b64\u8fd9\u4e9b\u6210\u5206\u4e4b\u95f4\u7684\u534f\u540c\u4f5c\u7528\u8d77\u7740\u51b3\u5b9a\u6027\u7684\u4f5c\u7528\u3002.<br>\u9999\u8305\u9187\u8fd8\u80fd\u6291\u5236 NF-\u03baB\uff08\u4e0e MOGAD \u4e2d\u7684\u5c0f\u80f6\u8d28\u7ec6\u80de\u6d3b\u5316\u76f4\u63a5\u76f8\u5173\uff09\u3002.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Teebaum-Ol_Melaleuca_alternifolia_%E2%80%93_Mikroglia-Modulation\"><\/span>\u8336\u6811\u6cb9<em>Melaleuca alternifolia<\/em>) - \u5c0f\u80f6\u8d28\u7ec6\u80de\u8c03\u8282<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10350368\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u8336\u6811\u6cb9<\/a> \u53ca\u5176\u4e3b\u8981\u6210\u5206\u80fd\u6291\u5236 AChE \u548c BChE \u4ee5\u53ca LOX\u3002\u901a\u8fc7\u6297\u6c27\u5316\u7279\u6027\u3001\u795e\u7ecf\u708e\u75c7\u6291\u5236\u548c AChE\/BChE \u6291\u5236\u6765\u4f18\u5316\u6c27\u5316\u5e94\u6fc0\uff0c\u4f5c\u4e3a\u4e00\u79cd\u6574\u4f53\u7b56\u7565\uff0c\u53ef\u6709\u6548\u9884\u9632\u795e\u7ecf\u7ec6\u80de\u6b7b\u4ea1\u3002.<br>Terpinen-4-ol \uff08\u4e3b\u8981\u6d3b\u6027\u6210\u5206\uff09\u8fd8\u80fd\u7279\u522b\u6291\u5236\u5c0f\u80f6\u8d28\u7ec6\u80de M1 \u6781\u5316\u3002.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wirkstoffubersicht_nach_MOGAD-Signalwegen\"><\/span>\u6839\u636e MOGAD \u4fe1\u53f7\u901a\u8def\u5212\u5206\u7684\u6d3b\u6027\u7269\u8d28\u6982\u89c8<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>\u6d3b\u6027\u6210\u5206<\/th><th>\u6cb9\u6e90<\/th><th>MOGAD \u4fe1\u53f7\u901a\u8def<\/th><th>\u8bc1\u636e\u7684\u529b\u5ea6<\/th><\/tr><\/thead><tbody><tr><td><strong>\u03b2-\u8336\u78b1\uff08BCP\uff09<\/strong><\/td><td>\u9ed1\u80e1\u6912\u3001\u79d1\u5e15\u4f9d\u5df4<\/td><td>CB2 \u2192 Nrf2\/HO-1\u3001PPAR-\u03b3\uff1bTh17\u2193\u3001IL-6\u2193<\/td><td>\u2605\u2605\u2605\u2605 \uff08EAE \u6a21\u578b\uff09<\/td><\/tr><tr><td><strong>AKBA<\/strong><\/td><td>\u4e73\u9999 (<em>\u4e73\u9999<\/em>)<\/td><td>STAT3\u2193\u3001NF-\u03baB\u2193\u30015-LOX\u2193\u3001SPM\u2191\u3001Nrf2\/HO-1\u2191<\/td><td>\u2605\u2605\u2605\u2605 \uff08\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u7814\u7a76\uff09<\/td><\/tr><tr><td><strong>\u918b\u9178\u975b\u7ea2<\/strong><\/td><td>\u4e73\u9999\uff08\u6325\u53d1\u6027\u90e8\u5206\uff09<\/td><td>TRPV3\u3001PPAR-\u03b3\u3001IL-6\u2193\u3001GFAP\u2193<\/td><td>\u2605\u2605\u2605\uff08\u52a8\u7269\u6a21\u578b\uff09<\/td><\/tr><tr><td><strong>\u03b1-Asaron<\/strong><\/td><td>\u83d6\u84b2 (<em>\u6c34\u83d6\u84b2<\/em>)<\/td><td>PPAR-\u03b3 \u2192 GLT-1\u2191 \u2192 OPC \u4fdd\u62a4\uff0c\u76f4\u63a5\u518d\u9ad3\u9798\u5316<\/td><td>\u2605\u2605\u2605\uff08\u7f3a\u6c27\u6a21\u578b\uff09<\/td><\/tr><tr><td><strong>\u82b3\u6a1f\u9187<\/strong><\/td><td>\u85b0\u8863\u8349\u3001\u67e0\u6aac\u9999\u818f<\/td><td>NMDA \u8c03\u8282\u3001SERT\u3001\u795e\u7ecf\u4fdd\u62a4<\/td><td>\u2605\u2605\u2605<\/td><\/tr><tr><td><strong>1,8-\u848e\u70ef<\/strong><\/td><td>\u6849\u6811\u3001\u8ff7\u8fed\u9999<\/td><td>AChE \u6291\u5236\u5242\u3001\u6297\u6c27\u5316\u5242<\/td><td>\u2605\u2605\u2605\u2605\uff08\u5728\u5927\u8111\u4e2d\u5f97\u5230\u8bc1\u5b9e\uff09<\/td><\/tr><tr><td><strong>\u9999\u8305\u9187<\/strong><\/td><td>\u5929\u7afa\u8475<\/td><td>NO\u2193\u3001NF-\u03baB\u2193\u3001\u534f\u540c\u6548\u5e94<\/td><td>\u2605\u2605<\/td><\/tr><tr><td><strong>\u841c\u54c1\u70ef-4-\u9187<\/strong><\/td><td>\u8336\u6811<\/td><td>\u5c0f\u80f6\u8d28\u7ec6\u80de M1\u2193\u3001LOX\u2193\u3001AChE\u2193<\/td><td>\u2605\u2605<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Quellen_und_weiterfuhrende_Literatur\"><\/span><strong>\u8d44\u6599\u6765\u6e90\u548c\u8fdb\u4e00\u6b65\u9605\u8bfb<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Banwell B \u7b49\u4eba - Lancet Neurol.<\/strong> \u8bca\u65ad\u6807\u51c6 MOGAD<br><strong>PubMed\uff08\u514d\u8d39\uff09\uff1a<\/strong> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36706773\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/36706773\/<\/a> <br><strong>ScienceDirect\uff08\u6458\u8981\u514d\u8d39\uff0c\u5168\u6587\u9700\u4ed8\u8d39\uff09\uff1a<\/strong> <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1474442222004318\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1474442222004318<\/a> <br><strong>DOI\uff1a<\/strong> <a href=\"https:\/\/doi.org\/10.1016\/S1474-4422(22)00431-8\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1016\/S1474-4422(22)00431-8<\/a><\/li>\n\n\n\n<li><strong>Mader S \u7b49\u4eba - PNAS 2023<\/strong> <em>(\u6ce8\uff1a\u5728\u6211\u4eec\u7684\u6587\u4ef6\u4e2d\u88ab\u79f0\u4e3a \u201ePNAS 2024\"--\u6b63\u786e\u7684\u51fa\u7248\u5e74\u4efd\u662f 2023 \u5e74 3 \u6708\uff09<\/em> \u8865\u4f53\u4e0e FcR \u7684\u75c5\u7406\u673a\u5236\uff0c\u6155\u5c3c\u9ed1\u5927\u5b66<br><strong>\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a\u300b\u5168\u6587\uff08\u514d\u8d39\uff09\uff1a<\/strong> <a href=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2300648120\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2300648120<\/a> <br><strong>LMU \u65b0\u95fb\u7a3f\uff08\u9644\u89e3\u91ca\uff09\uff1a<\/strong> <a href=\"https:\/\/www.med.lmu.de\/bmc\/en\/news\/latest-news\/news-overview\/news\/autoimmune-disease-mogad-insights-into-pathomechanisms.html\" target=\"_blank\" rel=\"noopener\">https:\/\/www.med.lmu.de\/bmc\/en\/news\/latest-news\/news-overview\/news\/autoimmune-disease-mogad-insights-into-pathomechanisms.html<\/a> <br><strong>EAN \u6ce8\u91ca\uff1a<\/strong> <a href=\"https:\/\/www.ean.org\/research\/resources\/neurology-updates\/detail\/complement-dependent-and-independent-pathomechanisms-of-myelin-oligodendrocyte-glycoprotein-mog-abs-implications-for-therapeutic-strategies-in-mog-antibody-associated-disease-mogad\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.ean.org\/research\/resources\/neurology-updates\/detail\/complement-dependent-and-independent-pathomechanisms-of-myelin-oligodendrocyte-glycoprotein-mog-abs-implications-for-therapeutic-strategies-in-mog-antibody-associated-disease-mogad<\/a> <\/li>\n\n\n\n<li><strong>Kaneko K et al - Neurol Neuroimmunol Neuroinflamm.2024;11(5):e200293<\/strong> CSF \u8865\u4f53\u6fc0\u6d3b<br>e200293 \u53f7\u6587\u7ae0\u662f <strong>\u65e0\u6cd5\u76f4\u63a5\u627e\u5230<\/strong> - \u4e0d\u8fc7\uff0c\u540c\u4e00\u671f\u520a\u4e0a\u7684\u76f8\u5173 MOGAD \u8bc4\u8bba\u6587\u7ae0\uff08e200275\uff0c\u4f5c\u8005 Moseley\/Zamvil\uff09\u53ef\u4ee5\u67e5\u9605\uff1a<br><strong>\u795e\u7ecf\u75c5\u5b66\u300bNXI\uff08e200275\uff0c\u540c\u4e00\u671f\uff09\uff1a<\/strong> <a href=\"https:\/\/www.neurology.org\/doi\/10.1212\/NXI.0000000000200275\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.neurology.org\/doi\/10.1212\/NXI.0000000000200275<\/a> <br><strong>\u5728 PubMed \u4e0a\u641c\u7d22 Kaneko 2024 MOGAD CSF\uff1a<\/strong> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38996203\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/38996203\/<\/a> <em>(\u5f15\u5411 e200275 - \u5efa\u8bae\u76f4\u63a5\u5728 PubMed \u4e0a\u641c\u7d22 e200293\uff09<\/em><\/li>\n\n\n\n<li><strong>Cho EB et al - Front Immunol.<\/strong> \u4e92\u8865\u6a21\u5f0f MOGAD vs. NMOSD<br><strong>\u524d\u6cbf\uff08\u5168\u6587\u514d\u8d39\uff09\uff1a<\/strong> <a href=\"https:\/\/doi.org\/10.3389\/fimmu.2024.1320094\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.3389\/fimmu.2024.1320094<\/a> <em>(\u53ef\u76f4\u63a5\u8bbf\u95ee\u7684 DOI\uff09<\/em><\/li>\n\n\n\n<li><strong>\u514d\u75ab\u5b66\u524d\u6cbf 2025 - EAE \u6a21\u578b\u3001MOGAD \u53d1\u75c5\u673a\u5236<\/strong> <em>(\u6587\u4ef6\u4e2d\u4e00\u822c\u4f1a\u63d0\u5230--\u8fd9\u91cc\u6307\u7684\u662f\u5173\u4e8e\u4fe1\u53f7\u901a\u8def\/\u8def\u5f84\u673a\u5236\u7684\u7efc\u8ff0\u6587\u7ae0\uff09<\/em><br><strong>2025 (Sun et al., PMID 40406135)\uff1a<\/strong> <a href=\"https:\/\/doi.org\/10.3389\/fimmu.2025.1535571\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.3389\/fimmu.2025.1535571<\/a><\/li>\n\n\n\n<li><strong>PMC 2023 - \u75c5\u7406\u751f\u7406\u5b66\u7efc\u5408\u590d\u4e60 MOGAD<\/strong><br><strong>PMC \u5168\u6587\uff08\u514d\u8d39\uff09\uff1a<\/strong> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9597055\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9597055\/<\/a><\/li>\n\n\n\n<li><strong>PMC 2024 - \u6700\u65b0\u56de\u987e\uff1a\u4e34\u5e8a\u8868\u73b0\u3001\u53d1\u75c5\u673a\u5236\u3001\u6cbb\u7597\u65b9\u6cd5<\/strong><br><strong>PubMed\/PMC (Trewin et al., Autoimmun Rev 2025)\uff1a<\/strong> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39577549\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/39577549\/<\/a><br><strong>PMC \u5168\u6587\uff1a<\/strong> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9294102\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9294102\/<\/a> <em>(\u5355\u514b\u9686\u6297\u4f53\u7597\u6cd5 NMOSD\/MOGAD)<\/em><\/li>\n\n\n\n<li><strong>St\u00f6gbauer J \u7b49\u4eba - Autoimmunity Reviews 2025;103970<\/strong> \u6210\u4eba MOGAD \u7684\u6cbb\u7597\u65b9\u6cd5<br><strong>ScienceDirect\uff08\u5f00\u653e\u83b7\u53d6\uff0c\u5168\u6587\u514d\u8d39\uff09\uff1a<\/strong> <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1568997225002319\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1568997225002319<\/a> <br><strong>DOI\uff1a<\/strong> <a href=\"https:\/\/doi.org\/10.1016\/j.autrev.2025.103970\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1016\/j.autrev.2025.103970<\/a> <br><strong>\u5fb7\u8bed\u6458\u8981<\/strong> <a href=\"https:\/\/www.reine-nervensache.de\/therapieansaetze-bei-mogad-von-der-akutbehandlung-zur-langfristigen-strategie\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.reine-nervensache.de\/therapieansaetze-bei-mogad-von-der-akutbehandlung-zur-langfristigen-strategie\/<\/a> <\/li>\n\n\n\n<li><strong>\u5173\u4e8e 2025 \u5e74\u65b0\u5174\u836f\u7269\u7684\u4e13\u5bb6\u610f\u89c1--\u4e34\u5e8a\u8bd5\u9a8c\u683c\u5c40<\/strong><br><strong>Tandfonline\uff08\u6458\u8981\u514d\u8d39\uff0c\u5168\u6587\u9700\u4ed8\u8d39\uff09\uff1a<\/strong> <a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14728214.2025.2565189\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14728214.2025.2565189<\/a><br><strong>DOI\uff1a<\/strong> <a href=\"https:\/\/doi.org\/10.1080\/14728214.2025.2565189\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1080\/14728214.2025.2565189<\/a><br><\/li>\n\n\n\n<li><strong>NEMOS \u7814\u7a76\u5c0f\u7ec4<\/strong> <a href=\"https:\/\/www.nemos-net.de\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.nemos-net.de<\/a><br><\/li>\n\n\n\n<li><strong>\u4ee5\u60a3\u8005\u4e3a\u5bfc\u5411\u7684\u7814\u7a76\u6982\u8ff0\uff08cosMOG\/METOROID\uff09\uff1a<\/strong><br>MOG \u9879\u76ee <a href=\"https:\/\/mogproject.org\/clinical-trials\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/mogproject.org\/clinical-trials\/<\/a><br>ClinicalTrials.gov - cosMOG - \u4e34\u5e8a\u8bd5\u9a8c <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05063162\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/clinicaltrials.gov\/study\/NCT05063162<\/a><\/li>\n<\/ul>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\">\u6240\u6709\u5185\u5bb9\u5747\u7ecf\u8fc7\u8ba4\u771f\u7814\u7a76\uff0c\u53cd\u6620\u4e86\u5f53\u524d\uff0802.2026\uff09\u516c\u5e03\u7684\u77e5\u8bc6\u6c34\u5e73\u3002\u5b83\u4ec5\u4f9b\u53c2\u8003\uff0c\u4e0d\u80fd\u53d6\u4ee3\u4e13\u4e1a\u533b\u7597\u54a8\u8be2\u3002.<br>\u6240\u6709\u5242\u91cf\u5efa\u8bae\u90fd\u5fc5\u987b\u5f81\u5f97\u4e3b\u6cbb\u533b\u751f\u7684\u540c\u610f\u3002. <br>\u76f8\u5173\u7814\u7a76\u4e3a\u4ece\u4e1a\u4eba\u5458\u63d0\u4f9b\u4e86\u8fdb\u4e00\u6b65\u7684\u533b\u5b66\u548c\u79d1\u5b66\u4fe1\u606f\u3002.<\/p>\n<\/blockquote>","protected":false},"excerpt":{"rendered":"<p><span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">\u9605\u8bfb\u65f6\u95f4<\/span> <span class=\"rt-time\"> 17<\/span> <span class=\"rt-label rt-postfix\">\u5206\u949f<\/span><\/span>Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease Was ist MOGAD? Jeder kennt elektrische Leitungen: Sie sind mit einer Isolierung versehen, die die einzelne Leiter im Kableb\u00fcndel von einander trennt, damit die Signale in ihnen einander nicht st\u00f6ren und unverf\u00e4lscht von A nach B gelangen.Das R\u00fcckenmark beinhaltet einen ganzen Strang vieler solcher Kabelb\u00fcndel. Sie leiten die Nervensignale vom&hellip;&nbsp;<a href=\"https:\/\/csiag.eu\/zh\/blog\/2026\/02\/17\/mogad-mog-antikoerper-assoziierte-erkrankung\/\" rel=\"bookmark\">\u9605\u8bfb\u66f4\u591a \u00bb<span class=\"screen-reader-text\">MOGAD - MOG \u6297\u4f53\u76f8\u5173\u75be\u75c5<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[1078,354],"tags":[94,5721,5717,5720,5714,5713,5711,5715,5719,5716,77,90,5712,5718],"class_list":["post-12718","post","type-post","status-publish","format-standard","hentry","category-medizin","category-medizin-gesundheit","tag-antikoerper","tag-bcp","tag-glykoprotein","tag-igg","tag-mog","tag-mogad","tag-molekulare-signalwege","tag-myelin","tag-myelinscheide","tag-oligodendrozyten","tag-pathophysiologie","tag-rezeptoren","tag-therapiekonzepte","tag-transmebranprotein"],"modified_by":"Achim Goerner","_links":{"self":[{"href":"https:\/\/csiag.eu\/zh\/wp-json\/wp\/v2\/posts\/12718","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csiag.eu\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csiag.eu\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csiag.eu\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csiag.eu\/zh\/wp-json\/wp\/v2\/comments?post=12718"}],"version-history":[{"count":0,"href":"https:\/\/csiag.eu\/zh\/wp-json\/wp\/v2\/posts\/12718\/revisions"}],"wp:attachment":[{"href":"https:\/\/csiag.eu\/zh\/wp-json\/wp\/v2\/media?parent=12718"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csiag.eu\/zh\/wp-json\/wp\/v2\/categories?post=12718"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csiag.eu\/zh\/wp-json\/wp\/v2\/tags?post=12718"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}